ALBERT

Description: There was a typographical error in [1, eq. (18)]. Instead of (Formula Presented). The equation describes the second-order statistics of the interferometric phases. Its significance lies in the fact that from it, one can derive the statistical properties of a wide range of quantities estimated from an interferometric stack, including the closure phases that we addressed in the paper. The other equations, numerical results, and the conclusions remain unaffected, because the error was of a purely typographical nature.

Description: Postdisaster search and rescue is an important application of ultrawideband (UWB) radar systems, which mainly detect trapped victims by their respiratory-motion response. The development of a respiratory-motion detection (RMD) algorithm that can eliminate nonstationary clutter and noise is a challenging task for the application. A new algorithm is proposed to deal with the task in this letter. It uses the multichannel singular spectrum analysis (MSSA) technique to reconstruct the respiratory-motion response detected by a UWB radar. During the reconstruction, the periodicity and range interrelation characteristics of the response are exploited to adaptively identify signal subspaces. The performance of the algorithm is verified both by simulated and real data. The results show its improved performance over the reference algorithms, e.g., a singular-value-decomposition-based algorithm. The adaptive-MSSA-based RMD algorithm has great promise not only in practical use but also for future research of UWB-radar-based human being remote sensing.

Description: Land–sea contamination observed in Soil Moisture and Ocean Salinity (SMOS) brightness temperature images is found to have two main contributions: the floor error inherent of image reconstruction and a multiplicative error either in the antenna temperature or in the visibility samples measured by the correlator. The origin of this last one is traced down to SMOS calibration parameters to yield a simple correction scheme, which is validated against several geophysical scenarios. Autoconsistency rules in interferometric synthesis together with redundant and complementary calibration procedures provide a robust SMOS calibration scheme.

Description: This letter proposes a novel algorithm, which is based on the generalized method of moments (GMM), for the estimation and correction of phase errors induced in synthetic aperture radar (SAR) imagery. The GMM algorithm is used to replace the original phase-estimation kernel in the basic structure of the phase-gradient-autofocus algorithm. Since this novel algorithm does not require the observed signal to be a certain distribution model, it is able to estimate arbitrary phase errors. The GMM algorithm has the ability of estimating range-dependent phase errors, which makes it an efficient estimator. As a result, higher accuracy of the estimated phase errors and a better focused image can be achieved. Excellent results have been obtained in autofocusing and imaging experiments on real SAR data.

Description: Strong clutter reflections of terrain and marine surfaces obscure the contrast between the target-of-interest and clutter (terrain and marine surface reflections) in synthetic aperture radar (SAR) images and consequently hinder the efficiency of image interpretation and analysis. To overcome this problem, this letter proposes an efficient clutter suppression method in SAR images, which is named shedding irrelevant patterns (SIP). The essence is to construct a regression function that can suppress clutter and preserve the target patterns concurrently. We assume that the clutter is irrelevant to the target-of-interest and distinguishable in patterns in terms of image-pixel distribution and intensity (spatial information). Experimental results show the efficiency of the proposed method in both clutter suppression and target pattern preservation.

Description: A concern in hyperspectral image classification is the high number of required training samples. When traditional classifiers are applied, feature reduction (FR) techniques are the most common approaches to deal with this problem. Subspace-based classifiers, which are developed based on high-dimensional space characteristics, are another way to handle the high dimension of hyperspectral images. In this letter, a novel subspace-based classification approach is proposed and compared with basic and improved subspace-based classifiers. The proposed classifier is also compared with traditional classifiers that are accompanied by an FR technique and the well-known support vector machine classifier. Experimental results prove the efficiency of the proposed method, especially when a limited number of training samples are available. Furthermore, the proposed method has a very high level of automation and simplicity, as it has no parameters to be set.

Description: To improve the spatial density of measurement points of persistent-scatterer interferometry, distributed scatterer (DS) should be considered and processed. An important procedure in DS interferometry is the phase triangulation (PT). This letter introduces two modified PT algorithms (i.e., equal-weighted PT and coherence-weighted PT) and analyzes the mathematical relations between different published PT methods (i.e., the maximum-likelihood phase estimator, least squares estimator, and eigendecomposition-based phase estimators). The analysis shows that the above five PT methods share very similar mathematical forms with different weight values in the estimation procedure.

Description: Sparse representation-based classifier and its variants have been widely adopted for hyperspectral image (HSI) classification recently. However, sparse representation is unstable so that similar features might obtain significantly different sparse codes. Despite the instability, we find that the sparse codes follow a class-dependent distribution under the structured dictionary consisting of training samples from all classes. Based on this observation, a novel discriminative feature, sparse code histogram (SCH), is developed for HSI classification. By counting the SCH of each sample from the sparse codes of its spatial neighbors, we can statistically obtain the distribution pattern of sparse codes of the class to which the sample belongs, and then treat the SCH as a new feature for classification. To reduce the possible outliers among the neighbors, a shape-adaptive neighborhood extractor is also employed to enhance the stability of the histogram feature. Experimental results demonstrate that SCH enjoys a strong discriminative power, which can achieve notably better performance than several state-of-the-art methods for HSI classification with limited training samples.

Description: Several detection statistics have been proposed for detecting fine ground disturbances between two synthetic aperture radar (SAR) images, such as vehicle tracks. The standard method involves estimating a local correlation coefficient between images. Other methods have been proposed using various statistical hypothesis tests. One of these alternative methods is a generalized likelihood ratio test (GLRT), which compares a full-correlation image model to a no-correlation image model. In this letter, we expand the GLRT to polarimetric SAR data and derive the appropriate GLRT detection statistics. Additionally, we explore relaxing the equal variance/equal polarimetric covariance assumptions used in previous results and find improved performance on macroscopic scene changes.

Description: For downward-looking linear array 3-D synthetic aperture radar, the resolution in cross-track direction is much lower than the ones in range and azimuth. Hence, superresolution reconstruction algorithms are desired. Since the cross-track signal to be reconstructed is sparse in the object domain, compressive sensing algorithm has been used. However, the imaging processing on the 3-D scene brings large computational loads, which renders challenges in both data acquisition and processing. To cover this shortage, truncated singular value decomposition is utilized to reconstruct a reduced-redundancy spatial measurement matrix. The proposed algorithm provides advantages in terms of computational time while maintaining the quality of the scene reconstructions. Moreover, our results on uniform linear array are generally applicable to sparse nonuniform linear array. Superresolution properties and reconstruction accuracies are demonstrated using simulations under the noise and clutter scenarios.

Description: This letter proposes a signal processing method of passive bistatic radar (PBR) exploiting an uncooperative radar as an illuminator. Compared with other opportunity illuminators, the transmitting signal of a radar usually has a better ambiguity function, which leads to a higher range resolution. Two channels are needed in PBR system. The reference channel is used to estimate radar signal parameters and reconstruct directly propagated signal. The surveillance channel is used to receive scattered wave. An array antenna and a simultaneous multibeam algorithm are necessary in the surveillance channel due to the flexible beam scanning of the uncooperative radar. The procedure of the proposed method is explained in detail, which is then followed by a field experiment. Preliminary results from the field experiment show that the proposed method can be applied to target angle and bistatic range measurement successfully.

Description: In order to achieve 3-D imaging with an airborne down-looking linear-array synthetic aperture radar (LASAR), a uniform virtual antenna array may be obtained by aperture synthesis of the cross-track sparse multiple-input–multiple-output array. However, the actual 3-D imaging quality is unavoidably degraded by errors in the virtual element position. In this letter, we investigate the effects of these errors on the forms and the degrees of image quality degradation by decomposing the error-related stochastic processes via an orthogonal transform based on discrete Legendre polynomials. It should be noted that these analyses are helpful for designing a LASAR system and providing a reference for specifying the requisite precision of measurement devices and calibration methods. Finally, we briefly consider the use of calibration methods to eliminate the effects of errors.

Description: In problems where labeled data are scarce, semisupervised learning (SSL) techniques are an attractive framework that can exploit both labeled and unlabeled data. These approaches typically rely on a smoothness assumption such that examples that are similar in input space should also be similar in label space. In many domains, such as remotely sensed hyperspectral image (HSI) classification, the data violate this assumption. In response, we propose a general method by which a neighborhood graph used in SSL is learned using binary classifiers that are trained to predict whether a pair of pixels shares the same label. Working within the framework of semisupervised neural networks (SSNNs), we show that our approach improves on the performance of the SSNN on two HSI data sets.

Description: In this letter, new models for the spatial correlation of sea clutter texture and intensity are proposed as improved versions of current power law models or exponential decay model. The models for texture have three unknown parameters, and thus can be called triparametric models. The structure of the models is a weighted sum of two components, which can describe the decaying process of the correlation coefficient with spatial lags, as well as the periodic behavior due to the existence of transient coherent structures in sea clutter. Unknown parameters are optimized by the nonlinear least square fit method. Models for sea clutter intensity can be obtained through a linear transform for uncorrelated speckle based on the compound-Gaussian representation of sea clutter. The proposed models are validated and compared with current models using S- and C-band measured sea clutter data. Analysis results indicate the effectiveness of the proposed models in that they can describe the behavior of spatial correlation coefficients with higher accuracy.

Description: Terrestrial laser scanning (TLS) has become a popular tool for acquiring source data points which can be used to construct digital elevation models (DEMs) for a wide number of applications. A TLS point cloud often has a very fine spatial resolution, which can represent well the spatial variation of a terrain surface. However, the uncertainty in DEMs created from this relatively new type of source data is not well understood, which forms the focus of this letter. TLS survey data representing four terrain surfaces of different characteristics were used to explore the effects of surface complexity and typical TLS data density (in terms of data point spacing) on DEM accuracy. The spatial variation in TLS data can be decomposed into parts corresponding to the signal of spatial variation (of terrain surfaces) and noise due to measurement error. We found a linear relation between the DEM error and the typical TLS data spacings considered (30–100 mm) which arises as a function of the interpolation error, and a constant contribution from the propagated data noise. This letter quantifies these components for each of the four surfaces considered and shows that, for the interpolation method considered here, higher density sampling would not be beneficial.

Description: A novel way to estimate the live fuel moisture content (LFMC) was explored from the ratio of canopy water content (CWC) and foliage dry biomass (FDB). The CWC was estimated using the PROSAIL (PROSPECT + SAIL) radiative transfer model from the Landsat 8 product. A weak constraint 4-D variational data assimilation method was employed to assimilate the temporally estimated leaf area index into a soil-water-atmosphere-plant (SWAP) model for optimizing the model control variables. Then, the SWAP model was reinitialized with this optimum set of control variables, and better prediction of FDB was obtained. Results showed that a high accuracy level was achieved for the estimated CWC ( $R^{2}=0.91$ , $mbox{RMSE}=84.74 mbox{g/m}^2$ ) and FDB ( $R^2=0.88$ , $mbox{RMSE}=48.54 mbox{g/m} ^2$ ) when compared with in situ measured values. However, the accuracy level of estimated LFMC was poor ( $R^2=0.59$ , $mbox{RMSE} =30.85%$ ) . Further analyses find that the estimated LFMC is reliable for low LFMC but challenged for high LFMC, which indicates that the presented method still makes sense to the assessment of wildfire risk since the wildfire generally occurs when the vegetation is in low LFMC condition.

Description: In this letter, we present the use of experimental human micro-Doppler signature data gathered by a multistatic radar system to discriminate between unarmed and potentially armed personnel walking along different trajectories. Different ways of extracting suitable features from the spectrograms of the micro-Doppler signatures are discussed, particularly empirical features such as Doppler bandwidth, periodicity, and others, and features extracted from singular value decomposition (SVD) vectors. High classification accuracy of armed versus unarmed personnel (between 90% and 97% depending on the walking trajectory of the people) can be achieved with a single SVD-based feature, in comparison with using four empirical features. The impact on classification performance of different aspect angles and the benefit of combining multistatic information is also evaluated in this letter.

Description: Automatic urban area detection in remote sensing images is an important application in the field of earth observation. Most of the existing methods employ feature classifiers and thereby contain a data training process. Moreover, some methods cannot detect urban areas in complex scenes accurately. This letter proposes an automatic urban area detection method that uses multiple features that have different resolutions. First, a downsampled low-resolution image is used to segment the candidate area. After the corner points of the urban area are extracted, a weighted Gaussian voting matrix technique is employed to integrate the corner points into the candidate area. Then, the edge features and homogeneous region are extracted by using the original high-resolution image. Using these results as the input, the processes of guided filtering and contrast enhancement can finally detect accurately the urban areas. This method combines multiple features, such as corner, edge, and regional characteristics, to detect the urban areas. The experimental results show that the proposed method has better detection accuracy for urban areas than the existing algorithms.

Description: In marine sciences, time series are often nonlinear and nonstationary. Adequate and specific methods are needed to analyze such series. In this letter, an application of the empirical mode decomposition method (EMD) associated to the Hilbert spectral analysis (HSA) is presented. Furthermore, EMD-based time-dependent intrinsic correlation (TDIC) analysis is applied to consider the correlation between two nonstationary time series. Four temperature time series obtained from automatic measurements in nearshore waters of the Réunion island are considered, recorded every 10 min from July 2011 to January 2012. The application of the EMD on these series and the estimation of their power spectra using the HSA are illustrated. The authors identify low-frequency tidal waves and display the pattern of correlations at different scales and different locations. By TDIC analysis, it was concluded that the high-frequency modes have small correlation, whereas the trends are perfectly correlated.

Description: Detecting vehicles in aerial images provides important information for traffic management and urban planning. Detecting the cars in the images is challenging due to the relatively small size of the target objects and the complex background in man-made areas. It is particularly challenging if the goal is near-real-time detection, i.e., within few seconds, on large images without any additional information, e.g., road database and accurate target size. We present a method that can detect the vehicles on a 21-MPixel original frame image without accurate scale information within seconds on a laptop single threaded. In addition to the bounding box of the vehicles, we extract also orientation and type (car/truck) information. First, we apply a fast binary detector using integral channel features in a soft-cascade structure. In the next step, we apply a multiclass classifier on the output of the binary detector, which gives the orientation and type of the vehicles. We evaluate our method on a challenging data set of original aerial images over Munich and a data set captured from an unmanned aerial vehicle (UAV).

Description: We compare five slope correction methods developed by Walter et al. , Montes et al. , Schleppi et al. , España et al. , and Gonsamo et al. (referred to as WAL, MON, SCH, ESP, and GON, respectively) using artificial fisheye pictures simulated by graphics software and a lookup table (LUT) retrieval method. The LUT is built by simulating the directional gap fraction as a function of leaf area index (LAI) and average leaf inclination angle (ALIA) using the Poisson law. LAI and ALIA estimates correspond to the case of the LUT that provides the lowest root-mean-square error between the observed gap fractions after slope correction and the simulated ones. Three LAI values (1.5, 3.5, and 5.5), four ALIA values (26.8°, 45°, 57.5°, and 63.2°), and three slope angles (0°, 20°, and 50°) constituted 36 samples of random scenes. ESP is recommended because its results are accurate and independent on the leaf angle distribution (LAD), while GON only performs well for spherical LAD. The three other methods present less good performances with underestimation or overestimation of LAI and/or ALIA depending on the LAD, and the recommended order for them is MON, SCH, and WAL.

Description: In this letter, an improved phase correlation (PC) method based on 2-D plane fitting and the maximum kernel density estimator (MKDE) is proposed, which combines the idea of Stone's method and robust estimator MKDE. The proposed PC method first utilizes a vector filter to minimize the noise errors of the phase angle matrix and then unwraps the filtered phase angle matrix by the use of the minimum cost network flow unwrapping algorithm. Afterward, the unwrapped phase angle matrix is robustly fitted via MKDE, and the slope coefficients of the 2-D plane indicate the subpixel shifts between images. The experiments revealed that the improved method can effectively avoid the impact of outliers on the phase angle matrix during the plane fitting and is robust to aliasing and noise. The matching accuracy can reach 1/50th of a pixel using simulated data. The real image sequence tracking experiment was also undertaken to demonstrate the effectiveness of the proposed PC method with a registration accuracy of root-mean-square error better than 0.1 pixels.

Description: Accurately mapping forest carbon density by combining sample plots and remotely sensed images has become popular because this method provides spatially explicit estimates. However, mixed pixels often impede the improvement of the estimation. In this letter, regression modeling and spectral unmixing analysis were integrated to improve the estimation of forest carbon density for the You County of Hunan, China, using Landsat Thematic Mapper images. Linear spectral unmixing with and without a constraint (LSUWC and LSUWOC) and nonlinear spectral unmixing (NSU) were compared to derive the fractions of five endmembers, particularly forests. Stepwise regression, logistic regression, and polynomial regression (PR) with and without the forest fraction used as an independent variable and the product of the forest fraction image and the map from the best model without the forest fraction were compared. The models were developed using 56 sample plots, and their results were validated using 26 test plots. The decomposition of mixed pixels was assessed using higher spatial resolution SPOT images and a corresponding land cover map. The results showed that 1) LSUWC more accurately estimated the endmember fractions than LSUWOC and NSU, 2) PR had the greatest estimation accuracy of forest carbon, and 3) combining regression modeling and spectral unmixing increased the estimation accuracy by 31%–39%, and introducing the forest fraction into the regressions performed better than the product of forest fraction image and the results from PR without the fraction. This implied that the integrations provided great potential in reducing the impacts of mixed pixels in mapping forest carbon.

Description: This letter proposes a multiresolution technique to address the high computational cost in remote sensing image registration. The scale-invariant feature transform is applied to detect keypoints and descriptors, and then, global information combined with descriptors is utilized to establish keypoint mappings. Keypoints are first classified according to their octaves. Then, in the lowest resolution, the keypoints of the largest octave are mapped with descriptors and the global information, giving an initial affine transformation $T_0$ . In the next octave, the keypoints of the second largest octave are mapped by employing $T_0$ to narrow the space of matching keypoints. By this means, the process of establishing keypoint correspondences is conducted from one resolution (octave) to the next as the obtained transformation gets finer until we get to the highest resolution. Due to the high computational expense of computing global information, the proposed technique is important for aligning large-size remote sensing imagery. Experimental results show that the proposed method can achieve a comparable registration accuracy but with a less computational cost than directly building keypoint mappings on images of large size.

Description: Gold nanorods (GNRs) with surface plasmon resonance peak at 1063.8 nm were fabricated and experimentally exploited as the single and combined saturable absorber (SA) in a $Q$ -switched Nd:YAG laser for the first time. In the situation using GNRs as a single SA, the maximum pulse energy of 19 $muhbox{J} $ was achieved at a pulse repetition rate of 20 kHz. However, due to the small effective modulation depth of the GNRs, microsecond pulses were generated in such a GNRs-based passively $Q$ -switched laser. A novel configuration using GNRs as a combined SA in an acoustooptic $Q$ -switched Nd:YAG laser was proposed. The small nonlinear loss modulation induced by the GNRs played a distinctive role in flexibly manipulating the nanosecond pulse waveforms. Our study demonstrated the feasibility of generating high-energy pulses by singly using GNRs-based SA in all solid-state lasers. Meanwhile, a new application mode incorporating GNRs as a combined SA was studied, providing an alternative method to take advantage of the nanomaterial-based SA with a relatively small modulation depth.

Description: Presents corrections to the paper, "Estimation of forest biomass from two-level model inversion of single-pass InSAR data" (Soja, M.J., et al.,Trans. Geosci. Remote Sens., vol. 53, no. 9, pp. 5083???5099, Sep. 2015).

Description: In this letter, we present an efficient parallel implementation of composite kernels in support vector machines (SVMs) for hyperspectral image (HSI) classification. Our implementation makes effective use of commodity graphics processing units (GPUs). Specifically, we port the calculation of composite kernels to GPUs, perform intensive computations based on NVidia's compute unified device architecture, and execute the rest of the operations related with control and small data calculations in the CPU. Our experimental results, conducted using real hyperspectral data sets and NVidia GPU platforms, indicate significant improvements in terms of computational effectiveness, achieving near-real-time performance of spatial–spectral HSI classification for the first time in the literature.

Description: Compared with airborne laser scanning, terrestrial laser scanning (TLS) offers ground-based point cloud data of trees and provides greater potential to accurately estimate tree and stand parameters. However, there is a lack of effective methods to accurately identify locations of individual trees from TLS point cloud data. It is also unknown whether the estimation accuracy of the parameters, including tree height (H), diameter at breast height (DBH), and so on, using TLS can meet the requirement of forest management and planning. In this letter, a novel method to effectively process point cloud data and further determine the locations of individual trees in a stand based on the central coordinates of point cloud data on a defined grid according to the largest DBH was developed. Moreover, a point-cloud-data-based convex hull algorithm and the cylinder method were, respectively, used to estimate DBH and H of individual trees. This study was conducted in a pure Chinese fir plantation of 45 trees located in Huang-Feng-Qiao forest farm, You County of Hunan, China. The comparison of the estimated and observed values showed that the obtained tree locations had errors of less than 20 cm, and the relative root mean square errors for the estimates of both DBH and H were less than 5%. This implies that TLS is very promising for the retrieval of tree and stand parameters in forest stands. For the applications of these methods to mixed forests with a structure of multilayer canopies, further examination is needed.

Description: Commercial, industrial, and military aerospace designs are increasingly deploying MEMS micro inertial measurement unit (MIMU) for motion control, automation, and positioning applications, such as the unmanned aerial vehicle (UAV), robot, and smart phone. On the one hand, MIMU has the merit of low cost, small size, low-power consumption, and high shock resistance, but on the other hand, low-cost MIMU is affected by systematic error caused by the instability of the drift, scaling factors, and axes misalignment, which may lead to large errors in the position and attitude’s determination from time to time. That means calibration before use is an effective way to improve the practical precision of MIMU. However, many customers have no precise turntable to calibrate the MIMU before they use it. To address these problems, this paper presents an easy self-calibration method to implement calibration of the MIMU on a common table only with an inclined surface, no precise turntable is needed. The calibration method is based on the following principles. First, the module of the output vector of the orthogonal configured three-axis accelerometers is equal to unit gravity. Second, when IMU rotates to a known gesture with a stable axis, the angles can be calculated through integration. Third, when the accelerometers’ parameters are calculated, it can act as a level datum. Furthermore, the accelerometers on the inclined surface are used to determine the rotating heading datum. Finally, after a series static positions test and rotating test, the parameters can be extracted and estimated. To demonstrate the success and the convenience of the proposed method, comparison experiments with the precision turntable have been made on an ADI’s MIMU. The calibration results show that the accuracy and precision of this method is quite equivalent with the turntable-based calibration, and the scale factors error with an order of magnitude always equal or less than $10^{-5}$ . The observed static and dynamic yaw maximum angular error in a certain period is <0.8°, the pitch maximum angular error is <0.5°, and the roll maximum angular error is <0.3°.

Description: Time–frequency packing (TFP) transmission provides the highest achievable spectral efficiency with a constrained symbol alphabet and detector complexity. In this paper, the application of the TFP technique to fiber-optic systems is investigated and experimentally demonstrated. The main theoretical aspects, design guidelines, and implementation issues are discussed, focusing on those aspects which are peculiar to TFP systems. In particular, adaptive compensation of propagation impairments, matched filtering, and maximum a posteriori probability detection are obtained by a combination of a two-dimensional equalizer and four eight-state parallel Bahl–Cocke–Jelinek–Raviv (BCJR) detectors. A novel algorithm that ensures adaptive equalization, channel estimation, and a proper distribution of tasks between the equalizer and BCJR detectors is proposed. A set of irregular low-density parity-check codes with different rates is designed to operate at low error rates and approach the spectral efficiency limit achievable by TFP at different signal-to-noise ratios. An experimental demonstration of the designed system is finally provided with five dual-polarization QPSK-modulated optical carriers, densely packed in a 100-GHz bandwidth, employing a recirculating loop to test the performance of the system at different transmission distances.

Description: We investigated nonlinear optical characteristics of Tungsten disulfide (WS 2 ) films and experimentally demonstrated their high potential for application as nonlinear saturable absorbers in passively mode-locked fiber lasers. Side polished fiber (SPF) was fabricated and WS 2 film was overlaid to provide an efficient evanescent field interaction. The WS 2 film was prepared using two methods: liquid phase exfoliation to form few-layer nano-sheets, and chemical vapor deposition (CVD) to grow uniform multilayer WS 2 on a SiO 2 substrate. Two SPF saturable absorbers were prepared by either spin coating WS 2 solution or lifting off the multilayer CVD WS 2 on SPF. An all-fiber ring cavity was built and the WS 2 film overlaid on SPF was employed as a mode locker along with Er-doped fiber as a gain medium. Using the spin-coated WS 2 SPF, stable soliton-like pulses were generated with a spectral width of 5.6 nm and 467 fs pulse duration. The fiber laser cavity containing CVD WS2 SPF generated a transform-limited soliton pulse train with a spectral width of 8.23 nm and a pulse duration of 332 fs. Our study confirmed a high potential of WS 2 film as a novel 2-D nonlinear optical material for laser applications.

Description: We propose and experimentally demonstrate an on-chip all-optical differential-equation solver capable of solving second-order ordinary differential equations (ODEs) characterizing continuous-time linear time-invariant systems. The photonic device is implemented by a self-coupled microresonator on a silicon-on-insulator platform with mutual coupling between the cavity modes. Owing to the mutual mode coupling within the same resonant cavity, the resonance wavelengths induced by different cavity modes are self-aligned, thus avoiding precise wavelength alignment and unequal thermal wavelength drifts as in the case of cascaded resonators. By changing the mutual mode coupling strength, the proposed device can be used to solve second-order ODEs with tunable coefficients. System demonstration using the fabricated device is carried out for 10-Gb/s optical Gaussian and super-Gaussian input pulses. The experimental results are in good agreement with theoretical predictions of the solutions, which verify the feasibility of the fabricated device as a tunable second-order photonic ODE solver.

Description: We demonstrate a 100 Gb/s short reach system using a multicarrier transmitter based on a gain switched monolithically integrated laser. An optical comb source with 12.5-GHz free spectral range is achieved by gain-switching an integrated passive feedback laser. The 100 Gb/s wavelength division multiplexed, single sideband, direct detection, orthogonal frequency division multiplexed (WDM-SSB-DD-OFDM) system operates over 25 km standard single mode fiber exhibiting a spectral efficiency of 1.8 b/s/Hz. Receiver sensitivity of –14.2 dBm is achieved after 25 km transmission. Performance optimization with phase and amplitude precompensation is employed to improve the SSB OFDM modulation thereby reducing the interchannel interference and overcoming the power fading induced by the optical filter. We also present a theoretical analysis of the SSB-OFDM modulation.

Description: In this paper, narrow-band emission lines are generated by means of two random distributed feedback fiber laser schemes. Spectral line-widths as narrow as 3.2 pm have been measured, which significantly improves previous reported results. The laser is analyzed with the aim of obtaining a spectral line-width as narrow as possible. Additionally a variation of this setup for multi-wavelength operation is also validated. Both schemes present a simple topology that use a combination of phase-shifted fiber Bragg gratings and regular fiber Bragg gratings as filtering elements.

Description: We report on the fabrication and characterization of 19-cell hypocycloid-shape Kagome fibers with core size larger than 100 μm. These inhibited coupling fibers present low propagation loss (100 dB/km) over broad transmission range with low chromatic dispersion combined with ultra-low power overlap with silica surround, making them an efficient solution for ultra-high power laser handling, ultra-fast laser delivery, and plasma photonics applications.

Description: The iterative demodulation and decoding algorithm introduced in 2005 by Colavolpe, Barbieri, and Caire to cope with channels affected by phase noise needs pilot symbols to bootstrap. However, pilot symbols reduce the spectral efficiency of the system and, consequently, system's throughput. The aim of this paper is to show that trellis-based demodulation can be used to bootstrap the iterative process without the need of pilot symbols. Also, the complexity issue of trellis-based demodulation is addressed in this paper. The result is that the performance of iterative demodulation and decoding after the iterations is virtually unaffected by complexity reduction, provided that the reduced-complexity demodulator guarantees cycle-slip-free operation. From the numerical results presented in this paper, we show that cycle-slip-free operation can be achieved with substantial complexity reduction also for phase noise associated with linewidths of practical interest.

Description: The optical pulse evolution in a highly nonlinear normal dispersion-increasing fiber has been considered, both experimentally and theoretically. It was found that large spectral broadening in tapered waveguides could occur without temporal instabilities and impose the linear frequency modulation, i.e., chirp, required for high-quality pulse compression. The pedestal-free pulses have been demonstrated after dechirping in a standard single-mode fiber.

Description: This work proposes a novel localized surface plasmon resonance (LSPR) biochemical sensor featuring high sensitivity and a high resolution. The sensor was divided into two subcomponents according to their distinct functions; namely, single-mode fiber and metal array. Single-mode fibers located on the left and right sides of the sensors function as the input and output for optical fiber signals. A metal array comprising an arrangement of cylindrical nanometal particles served as the detection area of the sensor. To effectively reduce the memory capacity and calculation time, two innovative techniques (i.e., object meshing and boundary meshing) were integrated with the finite element method. With the area of the triangular elements used as a basis, the object boundary, small object, medium object, and large objects were meshed at a ratio of 1:8:160:1600. The improved numerical simulation methods and six design procedures were adopted to develop and analyze the proposed LSPR biochemical sensor. The results show that the novel LSPR biochemical sensor outperformed two current high-performance biochemical sensors and provided additional advantages such as short length (approximately 430 μm), high resolution (approximately –120 dB), and high sensitivity (approximately 127 604 nm/RIU).

Description: We propose an ultra-broadband super light absorber by integrating different-sized tapered hyperbolic metamaterial (HMM) waveguides, each of which has a different and wide absorption band due to broadband slow-light response, into a unit cell. We numerically demonstrate that such an absorber is superior to a single-sized HMM absorber in terms of absorption bandwidth, while maintaining a comparable absorption efficiency. A three different-sized HMM absorber presents the capability of working with an ultra-wide frequency band ranging from 1 to 30 THz, which is much larger than previously proposed absorbers working in the same spectral region. Such a design shows great promise for a broad range of applications such as thermal emitters, photovoltaics, optical-chemical energy harvesting, and stealth technology, where ultra-wideband absorption is in very high demand.

Description: This paper proposes a ring-based integrated wireless optical network architecture and an associated protocol that involves Ethernet passive optical network (EPON) and long term evolution (LTE) wireless network. The architecture along with the proposed protocol is instrumental toward the reduction of handover delay. The proposed ring-based EPON architecture facilitates the implementation of the X2 interface for LTE network by enabling the optical network units of the EPON backhaul to directly communicate with each other. The work further discusses about an open access network architecture where a single EPON can be used by multiple mobile service providers without compromising information security. Extensive simulations have been carried out to evaluate the performance of the proposed network. An analytical model has been introduced to calculate the queuing delay experienced by the X2 interface. The model has been validated with the simulations results.

Description: High spectrum efficiency and fast restoration speed are highly desired for survivable elastic optical networks (EONs). In this paper, we take the advantages of failure-independent path-protecting preconfigured cycles (FIPP p -cycles) and investigate how to realize spectrum efficient resilience design with them. We first study the problem of offline service provisioning with FIPP p -cycles. We formulate an integer linear programming model and prove that the problem is $mathcal{NP}$ hard. Then, several time-efficient heuristics are designed for FIPP p -cycle formulation and related routing, modulation format, and spectrum assignment. Extensive simulations on offline provisioning verify that the heuristics can obtain near-optimal solutions. Next, we consider online service provisioning with FIPP p -cycles in dynamic EONs. In order to overcome the decrease of protection efficiency during dynamic network operation, we propose a p -cycle reconfiguration scheme to reoptimize protection structures on-the-fly. Simulation results demonstrate that the proposed algorithms can improve spectrum efficiency and reduce bandwidth blocking probability simultaneously.

Description: Photo-thermo-refractive (PTR) glasses are the class of polyfunctional materials that combine the properties of several monofunctional materials such as photo-refractive, laser, luminescent, and plasmonic ones. Based on PTR glasses, various diffractive holographic elements and photonic devices were developed in both the volume and fiber versions. In this paper, the fabrication of optical planar waveguides on PTR glass by low-temperature ion exchange is reported for the first time. Planar waveguides were fabricated through substituting the sodium ions in glass by silver, potassium, rubidium, and cesium ones from the nitrate melts. The silver waveguides were shown to have the largest depth (27 μm) and reveal no birefringence. For the silver waveguides, an increase in the refractive index is caused by differences in the polarizabilities of cations exchanged. The maximum increment of the refractive index was observed in the cesium waveguides (0.0512). An increase in the refractive index and also appearing the birefringence in potassium, rubidium, and cesium waveguides are found to be due to the compressive mechanical stresses and their relaxation. The potentialities of the ion exchange technology for fabricating, in PTR glasses, planar gradient waveguides with low losses (0.5 dB/cm) are demonstrated, the potentialities extending the application field of PTR glasses in photonics.

Description: In this letter, a novel algorithm for attitude measurement based on a 3-D electromagnetic model (3-D em-model) is proposed. The 3-D em-model is established offline based on the geometric structure of the target, and it can be used to predict the scattering features at different target attitudes. In order to measure the attitude of the air target, we design a bistatic step frequency radar system. The directions of the two radars' lines of sight (LOSs) relative to the target are acquired by matching the high-resolution range profiles (HRRPs) from the target echoes to the HRRPs generated from the 3-D em-model. Since the directions of two radars' LOSs relative to the Earth are already known, the absolute attitude of the target can be acquired. The innovative contributions of this letter are as follows: 1) A comprehensive theoretical analysis of air target attitude measurement based on its own 3-D em-model is proposed; 2) the method can be applied to different kinds of air targets such as aircraft, satellite, missile, etc.; 3) the proposed attitude measurement method does not require target motion model in advance; and 4) the proposed algorithm can be applied to any kind of step frequency waveforms. Experiments using both data predicted by a high-frequency electromagnetic code and data measured in the chamber verify the validity of the method.

Description: The Soil Moisture and Ocean Salinity (SMOS) and Soil Moisture Active Passive (SMAP) missions provide Level-1 brightness temperature (Tb) observations that are used for global soil moisture estimation. However, the nature of these Tb data differs: the SMOS Tb observations contain atmospheric and select reflected extraterrestrial (“Sky”) radiation, whereas the SMAP Tb data are corrected for these contributions, using auxiliary near-surface information. Furthermore, the SMOS Tb observations are multiangular, whereas the SMAP Tb is measured at 40° incidence angle only. This letter discusses how SMOS Tb, SMAP Tb, and radiative transfer modeling components can be aligned in order to enable a seamless exchange of SMOS and SMAP Tb data in soil moisture retrieval and assimilation systems. The aggregated contribution of the atmospheric and reflected Sky radiation is, on average, about 1 K for horizontally polarized Tb and 0.5 K for vertically polarized Tb at 40° incidence angle, but local and short-term values regularly exceed 5 K.

Description: by Cheng-Jui Lin, Tai-Cherng Liou, Chi-Feng Pan, Pei-Chen Wu, Fang-Ju Sun, Hsuan-Liang Liu, Han-Hsiang Chen, Chih-Jen Wu Evidence has shown that indoxyl sulfate (IS) and p-cresyl sulfate (PCS) may be alternative predictors of clinical outcomes in chronic kidney disease (CKD). Both toxins are derived from the gastrointestinal tract and metabolised in the liver. However, it is unclear whether the liver affects the production of IS and PCS. Here, we explore the association between IS and PCS levels in liver cirrhosis and a CKD-based cohort (N = 115). Liver and kidney function was assessed and classified by a Child-Pugh score (child A–C) and a modified version of the Modification of Diet in Renal Disease (MDRD) equation (Stages 1–4), respectively. An animal model was also used to confirm the two toxin levels in a case of liver fibrosis. In patients with early liver cirrhosis (child A), IS and PCS were significantly associated with CKD stages. In contrast, serum IS and PCS did not significantly change in advanced liver cirrhosis (child C). A stepwise multiple linear regression analysis also showed that T-PCS was significantly associated with stages of liver cirrhosis after adjusting for other confounding factors (B = -2.29, p = 0.012). Moreover, the serum and urine levels of T-PCS and T-IS were significantly lower in rats with liver failure than in those without ( p

Description: A multi-sensor addressing method for fiber Bragg grating aided fiber loop ringdown (FBG-FLRD) sensor array is proposed. It is capable of simultaneous measurement of temperature and force. Light from a wavelength-swept fiber laser (WSFL) is modulated into pulsed light to illuminate FBG-FLRD sensor array. Based on the time sequence of pulsed lights reflected by fiber Bragg grating array, each FBG-FLRD sensor can be distinguished. The time interval between the trigger signal of the WSFL and the pulsed light reflected by FBG offers temperature variation information. By measuring the ringdown time of each FBG-FLRD, the loss of fiber ring induced by temperature and force can be obtained. And then simultaneous measurement can be implemented in real time. To prove the validity of the proposed system, a six elements array is experimentally validated with interrogation frequency of 27.5 Hz.

Description: by Guangde Zhang, Hongbo Shi, Lin Wang, Meng Zhou, Zhenzhen Wang, Xiaoxia Liu, Liang Cheng, Weimin Li, Xueqi Li Myocardial infarction (MI) is a severe coronary artery disease and a leading cause of mortality and morbidity worldwide. However, the molecular mechanisms of MI have yet to be fully elucidated. In this study, we compiled MI-related genes, MI-related microRNAs (miRNAs) and known human transcription factors (TFs), and we then identified 1,232 feed-forward loops (FFLs) among these miRNAs, TFs and their co-regulated target genes through integrating target prediction. By merging these FFLs, the first miRNA and TF mediated regulatory network for MI was constructed, from which four regulators (SP1, ESR1, miR-21-5p and miR-155-5p) and three regulatory modules that might play crucial roles in MI were then identified. Furthermore, based on the miRNA and TF mediated regulatory network and literature survey, we proposed a pathway model for miR-21-5p, the miR-29 family and SP1 to demonstrate their potential co-regulatory mechanisms in cardiac fibrosis, apoptosis and angiogenesis. The majority of the regulatory relations in the model were confirmed by previous studies, which demonstrated the reliability and validity of this miRNA and TF mediated regulatory network. Our study will aid in deciphering the complex regulatory mechanisms involved in MI and provide putative therapeutic targets for MI.

Description: by Dominik Eichin, Juha P. Laurila, Sirpa Jalkanen, Marko Salmi The ectoenzyme CD73 catalyzes the hydrolysis of AMP, and is one of the most important producers of extracellular adenosine. On regulatory T cells, CD73 is necessary for immunosuppressive functions, and on Th17 cells CD73-generated adenosine exerts anti-inflammatory effects. However, the expression and function of CD73 in pro-inflammatory M1 and in immunosuppressive M2 macrophages is largely unknown. Here we show that CD73 expression and enzyme activity were induced in in vitro polarized pro-inflammatory human M(LPS+TNF) monocytes/macrophages, while CD73 was absent from immunosuppressive M(IL-4+M-CSF)-polarized macrophages. Inhibition of CD73 activity with the inhibitor AMPCP did not affect the polarization of human monocytes. In mice, CD73 was present on resident peritoneal macrophages. In striking contrast, elicited peritoneal macrophages remained CD73 negative regardless of their polarization towards either a pro-inflammatory M(LPS) or anti-inflammatory M(IL-4c) direction. Finally, the ability of peritoneal macrophages to polarize to pro- and anti-inflammatory cells was perfectly normal in CD73-deficient mice in vivo . These data indicate that, in contrast to other major leukocyte subpopulations, CD73 activity on macrophages does not play a major role in their polarization and that in mice host CD73 on any cell type is not required in vivo for peritoneal macrophage polarization towards either a pro- or an anti-inflammatory direction.

Description: by Hui San Ong, Mohd Syafiq Rahim, Mohd Firdaus-Raih, Effirul Ikhwan Ramlan The unique programmability of nucleic acids offers alternative in constructing excitable and functional nanostructures. This work introduces an autonomous protocol to construct DNA Tetris shapes (L-Shape, B-Shape, T-Shape and I-Shape) using modular DNA blocks. The protocol exploits the rich number of sequence combinations available from the nucleic acid alphabets, thus allowing for diversity to be applied in designing various DNA nanostructures. Instead of a deterministic set of sequences corresponding to a particular design, the protocol promotes a large pool of DNA shapes that can assemble to conform to any desired structures. By utilising evolutionary programming in the design stage, DNA blocks are subjected to processes such as sequence insertion, deletion and base shifting in order to enrich the diversity of the resulting shapes based on a set of cascading filters. The optimisation algorithm allows mutation to be exerted indefinitely on the candidate sequences until these sequences complied with all the four fitness criteria. Generated candidates from the protocol are in agreement with the filter cascades and thermodynamic simulation. Further validation using gel electrophoresis indicated the formation of the designed shapes. Thus, supporting the plausibility of constructing DNA nanostructures in a more hierarchical, modular, and interchangeable manner.

Description: by Nima Toosizadeh, Jane Mohler, David G. Armstrong, Talal K. Talal, Bijan Najafi Poor balance control and increased fall risk have been reported in people with diabetic peripheral neuropathy (DPN). Traditional body sway measures are unable to describe underlying postural control mechanism. In the current study, we used stabilogram diffusion analysis to examine the mechanism under which balance is altered in DPN patients under local-control (postural muscle control) and central-control (postural control using sensory cueing). DPN patients and healthy age-matched adults over 55 years performed two 15-second Romberg balance trials. Center of gravity sway was measured using a motion tracker system based on wearable inertial sensors, and used to derive body sway and local/central control balance parameters. Eighteen DPN patients (age = 65.4±7.6 years; BMI = 29.3±5.3 kg/m 2 ) and 18 age-matched healthy controls (age = 69.8±2.9; BMI = 27.0±4.1 kg/m 2 ) with no major mobility disorder were recruited. The rate of sway within local-control was significantly higher in the DPN group by 49% (healthy local-control slope = 1.23±1.06×10 -2 cm 2 /sec, P

Description: by Raphael H. Heiberger Today´s connected world allows people to gather information in shorter intervals than ever before, widely monitored by massive online data sources. As a dramatic economic event, recent financial crisis increased public interest for large companies considerably. In this paper, we exploit this change in information gathering behavior by utilizing Google query volumes as a "bad news" indicator for each corporation listed in the Standard and Poor´s 100 index. Our results provide not only an investment strategy that gains particularly in times of financial turmoil and extensive losses by other market participants, but reveal new sectoral patterns between mass online behavior and (bearish) stock market movements. Based on collective attention shifts in search queries for individual companies, hence, these findings can help to identify early warning signs of financial systemic risk. However, our disaggregated data also illustrate the need for further efforts to understand the influence of collective attention shifts on financial behavior in times of regular market activities with less tremendous changes in search volumes.

Description: by Sea H. Kim, Birendra Babu Adhikari, Siobanth Cruz, Michael P. Schramm, Joe A. Vinson, Vasanthy Narayanaswami The objective of this study is to transport and deliver resveratrol to intracellular sites using apolipoprotein E3 (apoE3). Reconstituted high-density lipoprotein (rHDL) bearing resveratrol (rHDL/res) was prepared using phospholipids and the low-density lipoprotein receptor (LDLr)-binding domain of apoE3. Biophysical characterization revealed that resveratrol was partitioned into the phospholipid bilayer of discoidal rHDL/res particles (~19 nm diameter). Co-immunoprecipitation studies indicated that the LDLr-binding ability of apoE3 was retained. Cellular uptake of resveratrol to intracellular sites was evaluated in glioblastoma A-172 cells by direct fluorescence using chemically synthesized NBD-labeled resveratrol (res/NBD) embedded in rHDL/res. Competition and inhibition studies indicate that the uptake is by receptor mediated endocytosis via the LDLr, with co-localization of apoE3 and res/NBD in late endosomes/lysosomes. We propose that rHDL provides an ideal hydrophobic milieu to sequester resveratrol and that rHDL containing apoE3 serves as an effective “nanovehicle” to transport and deliver resveratrol to targeted intracellular sites.

Description: by JunLi Liu, YiHu Wang, ShuJun Song, XiJie Wang, YaYa Qin, ShaoYan Si, YanChuan Guo Purpose Collagen peptides (CPs) and calcium citrate are commonly used as bone health supplements for treating osteoporosis. However, it remains unknown whether the combination of oral bovine CPs with calcium citrate is more effective than administration of either agent alone. Methods Forty 12-week-old Sprague-Dawley rats were randomly divided into five groups ( n = 8) for once-daily intragastric administration of different treatments for 3 months at 3 months after ovariectomy (OVX) as follows: sham + vehicle; OVX + vehicle; OVX + 750 mg/kg CP; OVX + CP-calcium citrate (75 mg/kg); OVX + calcium citrate (75 mg/kg). After euthanasia, the femurs were removed and analyzed by dual energy X-ray absorptiometry and micro-computed tomography, and serum samples were analyzed for bone metabolic markers. Results OVX rats supplemented with CPs or CP-calcium citrate showed osteoprotective effects, with reductions in the OVX-induced decreases in their femoral bone mineral density. Moreover, CP-calcium citrate prevented trabecular bone loss, improved the microarchitecture of the distal femur, and significantly inhibited bone loss with increased bone volume, connectivity density, and trabecular number compared with OVX control rats. CP or CP-calcium citrate administration significantly increased serum procollagen type I N-terminal propeptide levels and reduced serum bone-specific alkaline phosphatase, osteocalcin, and C-telopeptide of type I collagen levels. Conclusions Our data indicate that combined oral administration of bovine CPs with calcium citrate inhibits bone loss in OVX rats. The present findings suggest that combined oral administration of bovine CPs with calcium citrate is a promising alternative for reducing bone loss in osteopenic postmenopausal women.

Description: by Jennifer Choe Bush, Peter Christopher Pantelis, Xavier Morin Duchesne, Sebastian Alexander Kagemann, Daniel Patrick Kennedy We present a novel “Gaze-Replay” paradigm that allows the experimenter to directly test how particular patterns of visual input—generated from people’s actual gaze patterns—influence the interpretation of the visual scene. Although this paradigm can potentially be applied across domains, here we applied it specifically to social comprehension. Participants viewed complex, dynamic scenes through a small window displaying only the foveal gaze pattern of a gaze “donor.” This was intended to simulate the donor’s visual selection, such that a participant could effectively view scenes “through the eyes” of another person. Throughout the presentation of scenes presented in this manner, participants completed a social comprehension task, assessing their abilities to recognize complex emotions. The primary aim of the study was to assess the viability of this novel approach by examining whether these Gaze-Replay windowed stimuli contain sufficient and meaningful social information for the viewer to complete this social perceptual and cognitive task. The results of the study suggested this to be the case; participants performed better in the Gaze-Replay condition compared to a temporally disrupted control condition, and compared to when they were provided with no visual input. This approach has great future potential for the exploration of experimental questions aiming to unpack the relationship between visual selection, perception, and cognition.

Description: by David G. Warnock, Daniel G. Bichet, Myrl Holida, Ozlem Goker-Alpan, Kathy Nicholls, Mark Thomas, Francois Eyskens, Suma Shankar, Mathews Adera, Sheela Sitaraman, Richie Khanna, John J. Flanagan, Brandon A. Wustman, Jay Barth, Carrolee Barlow, Kenneth J. Valenzano, David J. Lockhart, Pol Boudes, Franklin K. Johnson Trial Registration ClinicalTrials.gov NCT01196871

Description: by Clementine Menz, Mahroo K. Parsi, Julian R. J. Adams, Mohamed A. Sideek, Zlatko Kopecki, Allison J. Cowin, Mark A. Gibson Latent transforming growth factor-beta-1 binding protein-2 (LTBP-2) belongs to the fibrillin-LTBP superfamily of extracellular matrix proteins. LTBPs and fibrillins are involved in the sequestration and storage of latent growth factors, particularly transforming growth factor β (TGF-β), in tissues. Unlike other LTBPs, LTBP-2 does not covalently bind TGF-β, and its molecular functions remain unclear. We are screening LTBP-2 for binding to other growth factors and have found very strong saturable binding to fibroblast growth factor-2 (FGF-2) (Kd = 1.1 nM). Using a series of recombinant LTBP-2 fragments a single binding site for FGF-2 was identified in a central region of LTBP-2 consisting of six tandem epidermal growth factor-like (EGF-like) motifs (EGFs 9–14). This region was also shown to contain a heparin/heparan sulphate-binding site. FGF-2 stimulation of fibroblast proliferation was completely negated by the addition of 5-fold molar excess of LTBP-2 to the assay. Confocal microscopy showed strong co-localisation of LTBP-2 and FGF-2 in fibrotic keloid tissue suggesting that the two proteins may interact in vivo. Overall the study indicates that LTBP-2 is a potent inhibitor of FGF-2 that may influence FGF-2 bioactivity during wound repair particularly in fibrotic tissues.

Description: by Xinwei Shi, Hao Liu, Jing Cao, Qing Liu, Guiju Tang, Wanlu Liu, Haiyi Liu, Dongrui Deng, Fuyuan Qiao, Yuanyuan Wu Objective Extravillous trophoblast (EVT) cells invade the endometrium and the maternal spiral arterioles during the first trimester. Mammary Serine Protease Inhibitor (Maspin, SERPINB5) plays a putative role in regulating the invasive activity of cytotrophoblasts. The maspin gene is silenced in various cancers by an epigenetic mechanism that involves aberrant cytosine methylation. We investigated the effect of the methylation status of the maspin promoter on the maspin expression and the aggressiveness of EVT cells. Methods Western blotting was used to detect the maspin protein expression in EVT cells upon hypoxia. The proliferative ability, the apoptosis rate and the migration and invasiveness were measured with Cell Counting Kit-8 assay, Flow Cytometry technology and Transwell methods. Subsequently, we treated cells with recombinant maspin protein. The methylation degree of maspin promoter region upon hypoxia/ decitabine was detected by bisulfite sequencing PCR and methylation-specific PCR. Finally, we explored the effects of decitabine on maspin protein expression and the aggressiveness of EVT cells. Results Hypoxia effectively increased maspin protein expression in EVT cells and significantly inhibited their aggressiveness. The addition of recombinant maspin protein inhibited this aggressiveness. Decitabine reduced the methylation in the maspin promoter region and effectively increased the maspin protein expression, which significantly weakened the migration and invasiveness of EVT cells. Discussion The methylation status of the maspin promoter is an important factor that affects the migration and invasion of EVT cells during early pregnancy. A decrease in the methylation status can inhibit the migration and invasion of EVT cells to affect placentation and can result in the ischemia and hypoxia of placenta.

Description: by Jun-Ha Hwang, Mi Ran Byun, A. Rum Kim, Kyung Min Kim, Hang Jun Cho, Yo Han Lee, Juwon Kim, Mi Gyeong Jeong, Eun Sook Hwang, Jeong-Ho Hong Mesenchymal stem cell (MSC) differentiation is regulated by the extracellular matrix (ECM) through activation of intracellular signaling mediators. The stiffness of the ECM was shown to be an important regulatory factor for MSC differentiation, and transcriptional coactivator with PDZ-binding motif (TAZ) was identified as an effector protein for MSC differentiation. However, the detailed underlying mechanism regarding the role of ECM stiffness and TAZ in MSC differentiation is not yet fully understood. In this report, we showed that ECM stiffness regulates MSC fate through ERK or JNK activation. Specifically, a stiff hydrogel matrix stimulates osteogenic differentiation concomitant with increased nuclear localization of TAZ, but inhibits adipogenic differentiation. ERK and JNK activity was significantly increased in cells cultured on a stiff hydrogel. TAZ activation was induced by ERK or JNK activation on a stiff hydrogel because exposure to an ERK or JNK inhibitor significantly decreased the nuclear localization of TAZ, indicating that ECM stiffness-induced ERK or JNK activation is important for TAZ-driven osteogenic differentiation. Taken together, these results suggest that ECM stiffness regulates MSC differentiation through ERK or JNK activation.

Description: by Maria Cecilia P. Moura, Steven J. Smith, David B. Belzer Residential buildings are a key driver of energy consumption and also impact transportation and land-use. Energy consumption in the residential sector accounts for one-fifth of total U.S. energy consumption and energy-related CO 2 emissions, with floor space a major driver of building energy demands. In this work a consistent, vintage-disaggregated, annual long-term series of U.S. housing stock and residential floor space for 1891–2010 is presented. An attempt was made to minimize the effects of the incompleteness and inconsistencies present in the national housing survey data. Over the 1891–2010 period, floor space increased almost tenfold, from approximately 24,700 to 235,150 million square feet, corresponding to a doubling of floor space per capita from approximately 400 to 800 square feet. While population increased five times over the period, a 50% decrease in household size contributed towards a tenfold increase in the number of housing units and floor space, while average floor space per unit remains surprisingly constant, as a result of housing retirement dynamics. In the last 30 years, however, these trends appear to be changing, as household size shows signs of leveling off, or even increasing again, while average floor space per unit has been increasing. GDP and total floor space show a remarkably constant growth trend over the period and total residential sector primary energy consumption and floor space show a similar growth trend over the last 60 years, decoupling only within the last decade.

Description: by Yi-Ling Chen, Shiun Chang, Ting-Ting Chen, Chien-Kuo Lee Dendritic cells (DCs), including conventional DCs (cDCs) and plasmacytoid DCs (pDCs) are critical for initiating and controlling the immune response. However, study of DC, particularly pDC, function is hampered by their low frequency in lymphoid organs, and existing methods for in vitro DC generation preferentially favor the production of cDCs over pDCs. Here, we demonstrated that pDCs could be efficiently generated in vitro from common lymphoid progenitors (CLPs) using Flt3 ligand (FL) in three different culture systems, namely feeder-free, BM-feeder and AC-6-feeder. This was in stark contrast to common DC progenitors (CDPs), in which cDCs were prominently generated under the same conditions. Moreover, the efficiency and function of pDCs generated from these three systems varied. While AC-6 system showed the greatest ability to support pDC development from CLPs, BM-feeder system was able to develop pDCs with better functionality. pDCs could also be expanded in vivo using hydrodynamic gene transfer of FL, which was further enhanced by the combined treatment of FL and IFN-α. Interestingly, IFN-α selectively promoted the proliferation of CLPs and not CDPs, which might contribute to enhanced pDC development. Together, we have defined conditions for in vitro and in vivo generation of pDCs, which may be useful for investigating the biology of pDCs.

Description: by Andrew Erwin, Frank C. Sup In this paper, a novel haptic feedback scheme, used for accurately positioning a 1DOF virtual wrist prosthesis through sensory substitution, is presented. The scheme employs a three-node tactor array and discretely and selectively modulates the stimulation frequency of each tactor to relay 11 discrete haptic stimuli to the user. Able-bodied participants were able to move the virtual wrist prosthesis via a surface electromyography based controller. The participants evaluated the feedback scheme without visual or audio feedback and relied solely on the haptic feedback alone to correctly position the hand. The scheme was evaluated through both normal (perpendicular) and shear (lateral) stimulations applied on the forearm. Normal stimulations were applied through a prototype device previously developed by the authors while shear stimulations were generated using an ubiquitous coin motor vibrotactor. Trials with no feedback served as a baseline to compare results within the study and to the literature. The results indicated that using normal and shear stimulations resulted in accurately positioning the virtual wrist, but were not significantly different. Using haptic feedback was substantially better than no feedback. The results found in this study are significant since the feedback scheme allows for using relatively few tactors to relay rich haptic information to the user and can be learned easily despite a relatively short amount of training. Additionally, the results are important for the haptic community since they contradict the common conception in the literature that normal stimulation is inferior to shear. From an ergonomic perspective normal stimulation has the potential to benefit upper limb amputees since it can operate at lower frequencies than shear-based vibrotactors while also generating less noise. Through further tuning of the novel haptic feedback scheme and normal stimulation device, a compact and comfortable sensory substitution device for upper limb amputees might be created.

Description: by Aparajita Chatterjee, Daniel M. Ratner, Christopher M. Ryan, Patricia J. Johnson, Barry R. O’Keefe, W. Evan Secor, Deborah J. Anderson, Phillips W. Robbins, John Samuelson Trichomonas vaginalis causes vaginitis and increases the risk of HIV transmission by heterosexual sex, while Tritrichomonas foetus causes premature abortion in cattle. Our goals were to determine the effects, if any, of anti-retroviral lectins, which are designed to prevent heterosexual transmission of HIV, on adherence of Trichomonas to ectocervical cells and on Tritrichomonas infections in a mouse model. We show that Trichomonas Asn-linked glycans ( N -glycans), like those of HIV, bind the mannose-binding lectin (MBL) that is part of the innate immune system. N -glycans of Trichomonas and Tritrichomonas bind anti-retroviral lectins (cyanovirin-N and griffithsin) and the 2G12 monoclonal antibody, each of which binds HIV N -glycans. Binding of cyanovirin-N appears to be independent of susceptibility to metronidazole, the major drug used to treat Trichomonas . Anti-retroviral lectins, MBL, and galectin-1 cause Trichomonas to self-aggregate and precipitate. The anti-retroviral lectins also increase adherence of ricin-resistant mutants, which are less adherent than parent cells, to ectocervical cell monolayers and to organotypic EpiVaginal tissue cells. Topical application of either anti-retroviral lectins or yeast N -glycans decreases by 40 to 70% the recovery of Tritrichomonas from the mouse vagina. These results, which are explained by a few simple models, suggest that the anti-retroviral lectins have a modest potential for preventing or treating human infections with Trichomonas .

Description: by Suzan J. W. Robroek, Anne Rongen, Coos H. Arts, Ferdy W. H. Otten, Alex Burdorf, Merel Schuring Background Individuals with lower socioeconomic status are at increased risk of involuntary exit from paid employment. To give sound advice for primary prevention in the workforce, insight is needed into the role of mediating factors between socioeconomic status and labour force participation. Therefore, it is aimed to investigate the influence of health status, lifestyle-related factors and work characteristics on educational differences in exit from paid employment. Methods 14,708 Dutch employees participated in a ten-year follow-up study during 1999–2008. At baseline, education, self-perceived health, lifestyle (smoking, alcohol, sports, BMI) and psychosocial (demands, control, rewards) and physical work characteristics were measured by questionnaire. Employment status was ascertained monthly based on tax records. The relation between education, health, lifestyle, work-characteristics and exit from paid employment through disability benefits, unemployment, early retirement and economic inactivity was investigated by competing risks regression analyses. The mediating effects of these factors on educational differences in exit from paid employment were tested using a stepwise approach. Results Lower educated workers were more likely to exit paid employment through disability benefits (SHR:1.84), unemployment (SHR:1.74), and economic inactivity (SHR:1.53) but not due to early retirement (SHR:0.92). Poor or moderate health, an unhealthy lifestyle, and unfavourable work characteristics were associated with disability benefits and unemployment, and an unhealthy lifestyle with economic inactivity. Educational differences in disability benefits were explained for 40% by health, 31% by lifestyle, and 12% by work characteristics. For economic inactivity and unemployment, up to 14% and 21% of the educational differences could be explained, particularly by lifestyle-related factors. Conclusions There are educational differences in exit from paid employment, which are partly mediated by health, lifestyle and work characteristics, particularly for disability benefits. Health promotion and improving working conditions seem important measures to maintain a productive workforce, particularly among workers with a low education.

Description: by SK Hafizul Islam, Muhammad Khurram Khan, Xiong Li Over the past few years, secure and privacy-preserving user authentication scheme has become an integral part of the applications of the healthcare systems. Recently, Wen has designed an improved user authentication system over the Lee et al.’s scheme for integrated electronic patient record (EPR) information system, which has been analyzed in this study. We have found that Wen’s scheme still has the following inefficiencies: (1) the correctness of identity and password are not verified during the login and password change phases; (2) it is vulnerable to impersonation attack and privileged-insider attack; (3) it is designed without the revocation of lost/stolen smart card; (4) the explicit key confirmation and the no key control properties are absent, and (5) user cannot update his/her password without the help of server and secure channel. Then we aimed to propose an enhanced two-factor user authentication system based on the intractable assumption of the quadratic residue problem (QRP) in the multiplicative group. Our scheme bears more securities and functionalities than other schemes found in the literature.

Description: by Sherif H. Elmeligy Abdelhamid, Chris J. Kuhlman, Madhav V. Marathe, Henning S. Mortveit, S. S. Ravi Discrete dynamical systems are used to model various realistic systems in network science, from social unrest in human populations to regulation in biological networks. A common approach is to model the agents of a system as vertices of a graph, and the pairwise interactions between agents as edges. Agents are in one of a finite set of states at each discrete time step and are assigned functions that describe how their states change based on neighborhood relations. Full characterization of state transitions of one system can give insights into fundamental behaviors of other dynamical systems. In this paper, we describe a discrete graph dynamical systems (GDSs) application called GDSCalc for computing and characterizing system dynamics. It is an open access system that is used through a web interface. We provide an overview of GDS theory. This theory is the basis of the web application; i.e., an understanding of GDS provides an understanding of the software features, while abstracting away implementation details. We present a set of illustrative examples to demonstrate its use in education and research. Finally, we compare GDSCalc with other discrete dynamical system software tools. Our perspective is that no single software tool will perform all computations that may be required by all users; tools typically have particular features that are more suitable for some tasks. We situate GDSCalc within this space of software tools.

Description: by Lisa Kellman, Amy Myette, Hugo Beltrami Forest harvesting induces a step change in the climatic variables (temperature and moisture), that control carbon dioxide ( CO 2 ) production arising from soil organic matter decomposition within soils. Efforts to examine these vertically complex relationships in situ within soil profiles are lacking. In this study we examined how the climatic controls on CO 2 production change within vertically distinct layers of the soil profile in intact and clearcut forest soils of a humid temperate forest system of Atlantic Canada. We measured mineral soil temperature (0, 5, 10, 20, 50 and 100 cm depth) and moisture (0–15 cm and 30–60 cm depth), along with CO 2 surface efflux and subsurface concentrations (0, 2.5, 5, 10, 20, 35, 50, 75 and 100 cm depth) in 1 m deep soil pits at 4 sites represented by two forest-clearcut pairs over a complete annual cycle. We examined relationships between surface efflux at each site, and soil heat, moisture, and mineral soil CO 2 production. Following clearcut harvesting we observed increases in temperature through depth (1–2°C annually; often in excess of 4°C in summer and spring), alongside increases in soil moisture (30%). We observed a systematic breakdown in the expected exponential relationship between CO 2 production and heat with mineral soil depth, consistent with an increase in the role moisture plays in constraining CO 2 production. These findings should be considered in efforts to model and characterize mineral soil organic matter decomposition in harvested forest soils.

Description: by Peng Yu, Jing Zhang, Shuchun Yu, Zhenzhong Luo, Fuzhou Hua, Linhui Yuan, Zhidong Zhou, Qin Liu, Xiaohong Du, Sisi Chen, Lieliang Zhang, Guohai Xu Background and Purpose Myocardial infarction leads to heart failure. Autophagy is excessively activated in myocardial ischemia/reperfusion (I/R) in rats. The aim of this study is to investigate whether the protection of sevoflurane postconditioning (SPC) in myocardial I/R is through restored impaired autophagic flux. Methods Except for the sham control (SHAM) group, each rat underwent 30 min occlusion of the left anterior descending coronary (LAD) followed by 2 h reperfusion. Cardiac infarction was determined by 2,3,5-triphenyltetrazolium chloride triazole (TTC) staining. Cardiac function was examined by hemodynamics and echocardiography. The activation of autophagy was evaluated by autophagosome accumulation, LC3 conversion and p62 degradation. Potential molecular mechanisms were investigated by immunoblotting, real-time PCR and immunofluorescence staining. Results SPC improved the hemodynamic parameters, cardiac dysfunction, histopathological and ultrastructural damages, and decreased myocardial infarction size after myocardial I/R injury ( P 〈 0.05 vs. I/R group). Compared with the cases in I/R group, myocardial ATP and NAD + content, mitochondrial function related genes and proteins, and the expressions of SOD2 and HO-1 were increased, while the expressions of ROS and Vimentin were decreased in the SPC group ( P 〈 0.05 vs. I/R group). SPC significantly activated Akt/mTOR signaling, and inhibited the formation of Vps34/Beclin1 complex via increasing expression of Bcl2 protein ( P 〈 0.05 vs. I/R group). SPC suppressed elevated expressions of LC3 II/I ratio, Beclin1, Atg5 and Atg7 in I/R rat, which indicated that SPC inhibited over-activation of autophagy, and promoted autophagosome clearance. Meanwhile, SPC significantly suppressed the decline of Opa1 and increases of Drp1 and Parkin induced by I/R injury ( P 〈 0.05 vs. I/R group). Moreover, SPC maintained the contents of ATP by reducing impaired mitochondria. Conclusion SPC protects rat hearts against I/R injury via ameliorating mitochondrial impairment, oxidative stress and rescuing autophagic clearance.

Description: by Lisa Müller, Erich Müller, Carolin Hildebrandt, Elmar Kornexl, Christian Raschner The relative age effect (RAE), which refers to an over-representation of selected athletes born early in the selection year, was proven to be present in alpine ski racing in all age categories at both national and international levels. However, the influential factors on, or the causal mechanisms of, the RAE are still unknown. Therefore, the aim of the present study was to examine three possible influential factors on the relative age effect in alpine skiing: physical performance, anthropometric characteristics and biological maturational status. The study included the investigation of 282 elite Austrian youth ski racers and 413 non-athletes (comparison group) of the same age (10–13 years) and region. Six physical performance tests were performed, body mass and height were assessed, and the age at peak height velocity (APHV) was calculated. A significant RAE was present in the ski racers. No differences were shown in the physical performance characteristics or in the calculated APHV between the relative age quarters. These results suggest that ski racers born in the last quarter can counteract the relative age disadvantages if they already present the same level of physical performance and maturational status as those born at the beginning of the year. The height and weight of ski racers born at the beginning of the year were significantly higher compared to the non-athletes, and ski racers born in relative age quarter 1 were taller and heavier compared to the ski racers of the other quarters. This indicates that the anthropometric characteristics influence the selection process in alpine ski racing, and that relatively older athletes are more likely to be selected if they exhibit advanced anthropometric characteristics.

Description: by Andrea Pelletier-Baldelli, Jessica A. Bernard, Vijay A. Mittal Social processes are key to navigating the world, and investigating their underlying mechanisms and cognitive architecture can aid in understanding disease states such as schizophrenia, where social processes are highly impacted. Evidence suggests that social processes are impaired in individuals at ultra high-risk for the development of psychosis (UHR). Understanding these phenomena in UHR youth may clarify disease etiology and social processes in a period that is characterized by significantly fewer confounds than schizophrenia. Furthermore, understanding social processing deficits in this population will help explain these processes in healthy individuals. The current study examined resting state connectivity of the salience (SN) and default mode networks (DMN) in association with facial emotion recognition (FER), an integral aspect of social processes, as well as broader social functioning (SF) in UHR individuals and healthy controls. Consistent with the existing literature, UHR youth were impaired in FER and SF when compared with controls. In the UHR group, we found increased connectivity between the SN and the medial prefrontal cortex, an area of the DMN relative to controls. In UHR youth, the DMN exhibited both positive and negative correlations with the somatosensory cortex/cerebellum and precuneus, respectively, which was linked with better FER performance. For SF, results showed that sensory processing links with the SN might be important in allowing for better SF for both groups, but especially in controls where sensory processing is likely to be unimpaired. These findings clarify how social processing deficits may manifest in psychosis, and underscore the importance of SN and DMN connectivity for social processing more generally.

Description: by Marc O. Nadon, Jerald S. Ault, Ivor D. Williams, Steven G. Smith, Gerard T. DiNardo The coral reef fish community of Hawaii is composed of hundreds of species, supports a multimillion dollar fishing and tourism industry, and is of great cultural importance to the local population. However, a major stock assessment of Hawaiian coral reef fish populations has not yet been conducted. Here we used the robust indicator variable “average length in the exploited phase of the population (L¯)”, estimated from size composition data from commercial fisheries trip reports and fishery-independent diver surveys, to evaluate exploitation rates for 19 Hawaiian reef fishes. By and large, the average lengths obtained from diver surveys agreed well with those from commercial data. We used the estimated exploitation rates coupled with life history parameters synthesized from the literature to parameterize a numerical population model and generate stock sustainability metrics such as spawning potential ratios (SPR). We found good agreement between predicted average lengths in an unfished population (from our population model) and those observed from diver surveys in the largely unexploited Northwestern Hawaiian Islands. Of 19 exploited reef fish species assessed in the main Hawaiian Islands, 9 had SPRs close to or below the 30% overfishing threshold. In general, longer-lived species such as surgeonfishes, the redlip parrotfish ( Scarus rubroviolaceus ), and the gray snapper ( Aprion virescens ) had the lowest SPRs, while short-lived species such as goatfishes and jacks, as well as two invasive species ( Lutjanus kasmira and Cephalopholis argus ), had SPRs above the 30% threshold.

Description: by Leonie J. P. Steenis, Marjolein Verhoeven, Dave J. Hessen, Anneloes L. van Baar Background The Bayley Scales of Infant and Toddler Development-third edition (Bayley-III) are frequently used to assess early child development worldwide. However, the original standardization only included US children, and it is still unclear whether or not these norms are adequate for use in other populations. Recently, norms for the Dutch version of the Bayley-III (The Bayley-III-NL) were made. Scores based on Dutch and US norms were compared to study the need for population-specific norms. Methods Scaled scores based on Dutch and US norms were compared for 1912 children between 14 days and 42 months 14 days. Next, the proportions of children scoring 〈 1-SD and 〈 -2 SD based on the two norms were compared, to identify over- or under-referral for developmental delay resulting from non-population-based norms. Results Scaled scores based on Dutch norms fluctuated around values based on US norms on all subtests. The extent of the deviations differed across ages and subtests. Differences in means were significant across all five subtests (p 〈 .01) with small to large effect sizes ( η p 2 ) ranging from .03 to .26). Using the US instead of Dutch norms resulted in over-referral regarding gross motor skills, and under-referral regarding cognitive, receptive communication, expressive communication, and fine motor skills. Conclusions The Dutch norms differ from the US norms for all subtests and these differences are clinically relevant. Population specific norms are needed to identify children with low scores for referral and intervention, and to facilitate international comparisons of population data.

Description: by Xiao-Dan Wang, Hui Lu, Zhihong Shi, Li Cai, Shuai Liu, Shuling Liu, Tong Han, Ying Wang, Yuying Zhou, Xinping Wang, Shuo Gao, Yong Ji Posterior cortical atrophy (PCA) is a clinicoradiologic neurodegenerative syndrome characterized by predominant impairment of higher visual functions. Neuroimaging and neuropathological studies show that PCA is probably an atypical presentation of Alzheimer’s disease. However, in China PCA has rarely been studied and remains largely unknown. Our study therefore aimed to analyze the clinical manifestations and patterns of cerebral atrophy, amyloid beta deposition and regional glucose metabolism in Chinese PCA patients, comparing them directly with those of typical Alzheimer’s disease (TAD). Seven PCA patients, 6 TAD patients and 5 controls underwent neuropsychological assessment, MRI scan, 11 C-PIB PET scan and 18 F-FDG PET scan. Cerebral atrophy including ventricular enlargement, posterior atrophy and medial temporal lobe atrophy were evaluated with MRI. The uptake of 11 C-PIB was quantified at the voxel level using the standardized uptake value ratio. Comparisons of regional cerebral glucose metabolism were calculated with statistical parametric mapping. PCA patients showed significant impairment on visuospatial function in neuropsychological assessment. And PCA patients showed more severe posterior atrophy and less severe left medial temporal lobe atrophy compared with TAD patients. The data from 11 C-PIB PET scanning showed that amyloid beta deposition in PCA was comparable to TAD. Moreover, in PCA the results from 18 F-FDG PET scanning revealed significant hypometabolism in the temporoparietooccipital region and identified specific hypometabolism in the right occipital lobe, compared with TAD. Our study thus provides a preliminary view of PCA in Chinese patients. A further study with a larger number of subjects would be recommended to confirm these findings.

Description: by Q. Wang, M. Li, Edmond H. M. Lou, M. S. Wong Background Non-ionizing radiation imaging assessment has been advocated for the patients with adolescent idiopathic scoliosis (AIS). As one of the radiation-free methods, ultrasound imaging has gained growing attention in scoliosis assessment over the past decade. The center of laminae (COL) method has been proposed to measure the spinal curvature in the coronal plane of ultrasound image. However, the reliability and validity of this ultrasound method have not been validated in the clinical setting. Objectives To evaluate the reliability and validity of clinical ultrasound imaging on lateral curvature measurements of AIS with their corresponding magnetic resonance imaging (MRI) measurements. Methods Thirty curves (ranged 10.2°–68.2°) from sixteen patients with AIS were eligible for this study. The ultrasound scan was performed using a 3-D ultrasound unit within the same morning of MRI examination. Two researchers were involved in data collection of these two examinations. The COL method was used to measure the coronal curvature in ultrasound image, compared with the Cobb method in MRI. The intra- and inter-rater reliability of the COL method was evaluated by intra-class correlation coefficient (ICC). The validity of this method was analyzed by paired Student’s t -test, Bland–Altman statistics and Pearson correlation coefficient. The level of significance was set as 0.05. Results The COL method showed high intra- and inter-rater reliabilities (both with ICC (2, K) 〉0.9, p

Description: by Yongkang Kim, Taesung Park Genome-wide association studies (GWAS) have successfully discovered hundreds of associations between genetic variants and complex traits. Most GWAS have focused on the identification of single variants. It has been shown that most of the variants that were discovered by GWAS could only partially explain disease heritability. The explanation for this missing heritability is generally believed to be gene-gene (GG) or gene-environment (GE) interactions and other structural variants. Generalized multifactor dimensionality reduction (GMDR) has been proven to be reasonably powerful in detecting GG and GE interactions; however, its performance has been found to decline when outlying quantitative traits are present. This paper proposes a robust GMDR estimation method (based on the L-estimator and M-estimator estimation methods) in an attempt to reduce the effects caused by outlying traits. A comparison of robust GMDR with the original MDR based on simulation studies showed the former method to outperform the latter. The performance of robust GMDR is illustrated through a real GWA example consisting of 8,577 samples from the Korean population using the Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) level as a phenotype. Robust GMDR identified the KCNH1 gene to have strong interaction effects with other genes on the function of insulin secretion.

Description: by Min Gao, Renli Tian, Junhao Wen, Qingyu Xiong, Bin Ling, Linda Yang In recent years, recommender systems have become an effective method to process information overload. However, recommendation technology still suffers from many problems. One of the problems is shilling attacks-attackers inject spam user profiles to disturb the list of recommendation items. There are two characteristics of all types of shilling attacks: 1) Item abnormality: The rating of target items is always maximum or minimum; and 2) Attack promptness: It takes only a very short period time to inject attack profiles. Some papers have proposed item anomaly detection methods based on these two characteristics, but their detection rate, false alarm rate, and universality need to be further improved. To solve these problems, this paper proposes an item anomaly detection method based on dynamic partitioning for time series. This method first dynamically partitions item-rating time series based on important points. Then, we use chi square distribution (χ 2 ) to detect abnormal intervals. The experimental results on MovieLens 100K and 1M indicate that this approach has a high detection rate and a low false alarm rate and is stable toward different attack models and filler sizes.

Description: by Morgan Kruse, Rebecca Wildner, Gisoo Barnes, Monique Martin, Udo Mueller, Francesco Lo-Coco, Ashutosh Pathak The objective of this study was to estimate the net cost of arsenic trioxide (ATO) added to all- trans retinoic acid (ATRA) compared to ATRA plus chemotherapy when used in first-line acute promyelocytic leukemia (APL) treatment for low to intermediate risk patients from the perspective of the overall Italian healthcare systemA Markov model was developed with 3 health states: stable disease, disease event and death. Each month, patients could move from stable to disease event or die from either state. After a disease event, patients discontinued initial treatment and switched to the other regimen as second-line therapy. Treatment regimens, efficacy and adverse events were derived from published sources and expert opinion; unit costs were collected from standard Italian sources. Clinical outcomes and costs for pre-ATO and post-ATO scenarios were combined with population and product utilization information to calculate the total budgetary impact using a 3-year time horizon; one-way sensitivity analyses were conducted. Three-year cumulative pharmacy costs for ATO+ATRA were €46,700 per-patient versus €6,500 for ATRA+chemotherapy; however, medical costs for ATO+ATRA were €12,300 per-patient versus €30,200 for ATRA+chemotherapy. The total budgetary impact was estimated to be an additional €127,300, €312,500 and €477,800 in the first, second and third years, respectively. The model was most sensitive to changes in the cost of the ATO+ATRA regimen during the consolidation phase. Budgetary impact models are valuable to payers making formulary decisions regarding the access and affordability of new medicines. The cost of treatment analysis showed that pharmacy costs for ATO+ATRA were higher than for ATRA+chemotherapy, while all other evaluated costs were lower for ATO+ATRA treated patients. The average budgetary impact was €305,900 per year overall, representing a 3.5% increase. Further research is needed to determine the cost-effectiveness of ATO+ATRA compared to the current first-line standard of care in APL.

Description: by Antonella Agodi, Martina Barchitta, Annalisa Quattrocchi, Andrea Maugeri, Manlio Vinciguerra Objective The Death-Associated Protein Kinase 1 ( DAPK1 ) gene has been frequently investigated in cervical cancer (CC). The aim of the present study was to carry out a systematic review and a meta-analysis in order to evaluate DAPK1 promoter methylation as an epigenetic marker for CC risk. Methods A systematic literature search was carried out. The Cochrane software package Review Manager 5.2 was used. The fixed-effects or random-effects models, according to heterogeneity across studies, were used to calculate odds ratios (ORs) and 95% Confidence Intervals (CIs). Furthermore, subgroup analyses were conducted by histological type, assays used to evaluate DAPK1 promoter methylation, and control sample source. Results A total of 20 papers, published between 2001 and 2014, on 1929 samples, were included in the meta-analysis. DAPK1 promoter methylation was associated with an increased CC risk based on the random effects model (OR: 21.20; 95%CI = 11.14–40.35). Omitting the most heterogeneous study, the between study heterogeneity decreased and the association increased (OR: 24.13; 95% CI = 15.83–36.78). The association was also confirmed in all the subgroups analyses. Conclusions A significant strong association between DAPK1 promoter methylation and CC was shown and confirmed independently by histological tumor type, method used to evaluate methylation and source of control samples. Methylation markers may have value in early detection of CC precursor lesions, provide added reassurances of safety for women who are candidates for less frequent screens, and predict outcomes of women infected with human papilloma virus.

Description: by Yufeng Huang, Chuchu Wang, Yufeng Yao, Xiaoyu Zuo, Shanshan Chen, Chengqi Xu, Hongfu Zhang, Qiulun Lu, Le Chang, Fan Wang, Pengxia Wang, Rongfeng Zhang, Zhenkun Hu, Qixue Song, Xiaowei Yang, Cong Li, Sisi Li, Yuanyuan Zhao, Qin Yang, Dan Yin, Xiaojing Wang, Wenxia Si, Xiuchun Li, Xin Xiong, Dan Wang, Yuan Huang, Chunyan Luo, Jia Li, Jingjing Wang, Jing Chen, Longfei Wang, Li Wang, Meng Han, Jian Ye, Feifei Chen, Jingqiu Liu, Ying Liu, Gang Wu, Bo Yang, Xiang Cheng, Yuhua Liao, Yanxia Wu, Tie Ke, Qiuyun Chen, Xin Tu, Robert Elston, Shaoqi Rao, Yanzong Yang, Yunlong Xia, Qing K. Wang Atrial fibrillation (AF) is the most common cardiac arrhythmia at the clinic. Recent GWAS identified several variants associated with AF, but they account for

Description: In this paper, the classification via sprepresentation and multitask learning is presented for target recognition in SAR image. To capture the characteristics of SAR image, a multidimensional generalization of the analytic signal, namely the monogenic signal, is employed. The original signal can be then orthogonally decomposed into three components: 1) local amplitude; 2) local phase; and 3) local orientation. Since the components represent the different kinds of information, it is beneficial by jointly considering them in a unifying framework. However, these components are infeasible to be directly utilized due to the high dimension and redundancy. To solve the problem, an intuitive idea is to define an augmented feature vector by concatenating the components. This strategy usually produces some information loss. To cover the shortage, this paper considers three components into different learning tasks, in which some common information can be shared. Specifically, the component-specific feature descriptor for each monogenic component is produced first. Inspired by the recent success of multitask learning, the resulting features are then fed into a joint sparse representation model to exploit the intercorrelation among multiple tasks. The inference is reached in terms of the total reconstruction error accumulated from all tasks. The novelty of this paper includes 1) the development of three component-specific feature descriptors; 2) the introduction of multitask learning into sparse representation model; 3) the numerical implementation of proposed method; and 4) extensive comparative experimental studies on MSTAR SAR dataset, including target recognition under standard operating conditions, as well as extended operating conditions, and the capability of outliers rejection.

Description: Offsets of synthetic aperture radar (SAR) images have played an important role in deriving complete three-dimensional (3-D) surface displacement fields in geoscientific applications. However, offset maps often suffer from multiple outliers and patch-like artifacts, because the standard offset-measurement method is a regular moving-window operation that does not consider the scattering characteristics of the ground. Here, we show that by focusing the offset measurements on predetected strong reflectors, the reliability and accuracy of SAR offsets can be significantly improved. Application to the 2011 Van (Turkey) earthquake reveals a clear deformation signal from an otherwise decorrelated interferogram, making derivation of the 3-D coseismic displacement field possible. Our proposed method can improve mapping of coseismic deformation and other ground displacements, such as glacier flow and landslide movement when strong reflectors exist.

Description: We present an accelerated probabilistic learning concept and its prototype implementation for mining heterogeneous Earth observation images, e.g., multispectral images, synthetic aperture radar (SAR) images, image time series, or geographical information systems (GIS) maps. The system prototype combines, at pixel level, the unsupervised clustering results of different features, extracted from heterogeneous satellite images and geographical information resources, with user-defined semantic annotations in order to calculate the posterior probabilities that allow the final probabilistic searches. The system is able to learn different semantic labels based on a newly developed Bayesian networks algorithm and allows different probabilistic retrieval methods of all semantically related images with only a few user interactions. The new algorithm reduces the computational cost, overperforming existing conventional systems, under certain conditions, by several orders of magnitude. The achieved speed-up allows the introduction of new feature models improving the learning capabilities of knowledge-driven image information mining systems and opening them to Big Data environments.

Description: The mineralogy and environmental history of Mars are being extensively studied through remote sensing observations paired with laboratory and in situ experiments. A significant portion of these experiments is being devoted to the identification and mapping of different iron oxides present in the Martian terrains. Among these compounds, goethite has been an object of great interest since its occurrence can be interpreted as mineralogical evidence of past aqueous activity on those landscapes. Although such experiments can provide valuable information regarding the presence of these minerals, the scope of the resulting observations may be hindered by logistics and cost-related constraints. We believe that predictive computer simulations can be employed to mitigate some of these constraints and contribute to the generation and validation of hypotheses in this area. Accordingly, we propose the use of SPLITS ( Sp ectral Li ght T ransport Model for S and) in investigations involving the spectral signatures of iron-bearing regions of Mars. In this paper, we initially demonstrate the predictive capabilities of the SPLITS model in this context through qualitative comparisons of modeled results with actual observations and measured data. Using the resulting modeled reflectance curves as our baseline data, we then perform a series of controlled computational experiments to investigate how variations on goethite and hematite content affect the spectral responses of Martian sand-textured soils.

Description: Thermal infrared (TIR) time series are exploited by many methods based on Earth observation (EO), for such applications as agriculture, forest management, and meteorology. However, due to physical limitations, data acquired by a single sensor are often unsatisfactory in terms of spatial or temporal resolution. This issue can be tackled by using remotely sensed data acquired by multiple sensors with complementary features. When nonreal-time functioning or at least near real-time functioning is admitted, the measurements can be profitably fed to a sequential Bayesian algorithm, which allows to account for the correlation embedded in the successive acquisitions. In this work, we focus on applications that allow the batch processing of the whole data sequences acquired in a fixed time interval. In this case, multiple options for improving the final product are offered by the Bayesian framework, based on both sequential and smoothing techniques. We consider several such Bayesian strategies and comparatively assess their performances in practical applications and through real thermal data acquired by the SEVIRI and MODIS sensors, encompassing the presence of multiple disturbance source, e.g., the cloud coverage of the illuminated scene.

Description: Land surface albedo, qualifying the ratio of the radiant flux reflected from the land surface to the incident flux, is a key forcing parameter controlling the Earth’s energy budget. Previously, several BRDF archetypes were distilled from high-quality MODIS BRDF/Albedo products. In this study, we propose a method that largely relies on matching observed multiangular reflectances with the most appropriate of these prior BRDF archetypes to determine the amplitude and shape of the actual surface BRDFs, when directional signatures are insufficient. This method is first evaluated using an assortment of multisource BRDF data sets to demonstrate its viability for surface albedo estimates, and then is applied to airborne wide-angle infrared dual-mode line/area array scanner (WIDAS) from the Watershed Allied Telemetry Experimental Research (WATER) campaign in the Heihe River Basin of China in 2008. This algorithm makes use of the linear MODIS BRDF model to determine the BRDF archetypes needed as prior knowledge for intrinsic spectral albedo estimates. The intrinsic spectral albedos are then used to estimate actual spectral albedos by considering the proportion of direct and diffuse solar radiation. A spectral-to-broadband conversion is performed to generate the broadband albedo at shortwave regimes through the use of conversion coefficients derived from extensive radiative transfer simulations. A further validation confirms that the estimated albedos are consistent with in situ field measured albedos over available corn crop sites. This method provides a major advantage on utilizing generalized BRDF information derived from MODIS in conjunction with other instrument data that are acquired with less angular variation.

Description: Ocean current is highly related to the interaction between ocean and atmosphere. By measuring the speed and direction of the ocean current from space, we can investigate the ocean–atmosphere interaction on a global scale. The ocean–atmosphere interaction helps to maintain the balance that is essential for planet habitability. However, the conventional scatterometer is unable to measure the ocean current vector. To achieve this, a potentially feasible approach is to use a bigger antenna, a higher PRF, and measure the interferometric phase of two successive echoes. This paper derives four decorrelation factors, and provides the phase error model first. Then, an end-to-end simulation model is established, and it is used to analyze the feasibility of ocean surface current measurement from space. Based on the simulation model, the system parameters are optimized. The simulation results show that the current speed standard deviation (Std), which means the measurement accuracy, in along-track and cross-track direction is smaller than 0.1 m/s when the wind speed is larger than 4 m/s. The swath can be used for current vector inversion that is greater than 70% when the wind speed is larger than 7 m/s. Meanwhile, ${{bf K}_{{bf pc}}}$ of the modified scatterometer is computed and the results show that ${{bf K}_{{bf pc}}}$ is better than the traditional pencil-beam rotating scatterometer when the wind speed is larger than 6 m/s.

Description: High-resolution three-dimensional (3-D) radar imaging of space targets in micromotion plays a significant role in space target recognition and space situation awareness; thus, it has attracted extensive attention in recent years. Because of the fast rotation, some scattering centers are occluded by others, i.e., the scattering centers cannot be continuously illuminated by radar in the imaging interval, and their radar echoes are discontinuous. In this paper, a nonparametric 3-D imaging method based on scattering center trajectory association is proposed. It deals with target occlusion using the Riemannian manifold optimization and obtains focused imaging of targets in complex micromotion. The effectiveness of the proposed method is validated using simulated data.

Description: Recently, satellite-based systems have been introduced that utilize angle-of-arrival (AOA) measurements to geo-locate objects of interest. In the previous work, we considered the application of nonlinear optimization to AoA-based geolocation to these systems. This previous work, however, assumed that all noise sources were independent. In the case of fast-moving objects, however, there is a significant source of error due to the propagation time inherent in satellite-based observation of objects due to the difference between the location of the object when it is observed by a satellite, and the location of the object when it emitted the signal that is being measured. This introduces a systematic error into the system that cannot be resolved by the system proposed by Burchett et al. In this paper, we extend our prior work to account for the time-delay inherent in satellite-based geolocation systems, making this system accurate for fast-movers as well as fixed or slow-moving objects. Results demonstrating significant improvement in geolocation performance both in terms of accuracy and estimated error bounds are presented.

Description: Most of existing change detection methods could be classified into three groups, the traditional pixel-based change detection (PBCD), the object-based change detection (OBCD), and the hybrid change detection (HCD). Nevertheless, both PBCD and OBCD have disadvantages, and classical HCD methods belong to intuitive decision-level fusion schemes of PBCD and OBCD. There is no optimum HCD method as of yet. Analyzing the complementarities of PBCD and OBCD method, we propose a new unsupervised algorithm-level fusion scheme (UAFS-HCD) in this paper to improve the accuracy of PBCD using spatial context information through: 1) getting the preliminary change mask with PBCD at first to estimate some parameters for OBCD; 2) deriving the unchanged area mask to eliminate the areas without changes, reducing error amplification phenomenon of OBCD; and 3) obtaining the final change mask by means of OBCD method. Taking flood detection with multitemporal SAR data as an example, we compared the new scheme with some classical methods, including PBCD, OBCD, and HCD method and supervised manual trial-and-error procedure (MTEP). The experimental results of flood detection showed that the new scheme was efficient and robust, and its accuracy sometimes can even exceed MTEP.

Description: Low-energy technologies in the Internet of Things (IoTs) era are still unable to provide the reliability needed by the industrial world, particularly in terms of the wireless operation that pervasive deployments demand. While the industrial wireless performance has achieved an acceptable degree in communications, it is no easy task to determine an efficient energy-dimensioning of the device in order to meet the application requirements. This is especially true in the face of the uncertainty inherent in energy harvesting. Thus, it is of utmost importance to model and dimension the energy consumption of the IoT applications at the pre-deployment or pre-production stages, especially when considering critical factors, such as reduced cost, life-time, and available energy. This paper presents a comprehensive model for the power consumption of wireless sensor nodes. The model takes a system-level perspective to account for all energy expenditures: communications, acquisition and processing. Furthermore, it is based only on parameters that can empirically be quantified once the platform (i.e., technology) and the application (i.e., operating conditions) are defined. This results in a new framework for studying and analyzing the energy life-cycles in applications, and it is suitable for determining in advance the specific weight of application parameters, as well as for understanding the tolerance margins and tradeoffs in the system.

Description: With the development of Internet of Things (IoT), a large amount of machine-to-machine (M2M) devices produce the data from a huge number of M2M communications. A massive access congestion control scheme in M2M communication is important in a wireless M2M network, where a wireless M2M network is constituted by a large number of wireless M2M devices. In this paper, we developed a spiderweb-based massive access management protocol for M2M wireless networks. The wireless M2M network topology considered, in this paper, is a spiderweb-based topology, which belongs to a regular topology. The spiderweb-based topology is split into a number of sub-spiderweb, while each sub-spiderweb can be seen as a small reservoir. The main function of the small reservoir is to temporarily store the massive access if the congestion problem is occurred due to the massive assess has been suddenly happened from the M2M devices. When the congestion problem is alleviated gradually, the temporarily-stored massive assess can be digested from these small reservoirs. The contribution of the proposed scheme is to reduce the packet loss rate and prolong the wireless M2M network lifetime. In addition, a dynamically adjustment of the different sub-spiderweb size is developed based on the amount of different data traffics. Simulation result finally illustrates that the proposed mechanism significantly reduces the packet loss rate and keeps the maximum network lifetime.

Description: The paper presents the methodology including the deployment of a structure comprising of C-clamp magnetic stripes and a self-calibration scheme using a four-coil design to resolve the issues of the interference and misplacement problems existing in the flexible nonintrusive current sensor tag for the current detection of household two-wire power lines. Experimental results show that the stripe structure can effectively screen out the magnetic flux originating from the nearby power line for the reduction of sensing error caused by the electromagnetic field interference and the calibration scheme containing the correction of horizontal misplacement and the analysis of power cable thickness via the four-coil design can provide the information of sensor location for accurate current sensing. Less than 4% of sensing error indicates that the proposed methodology can indeed facilitate the flexible current sensor tag for practical use.

Description: Rapidly emerging batteryless sensors are creating tremendous opportunities for truly wearable sensors for activity recognition. However, data streams from such sensors are characterized by sparsity and noise, which make activity recognition a challenging task. In this paper, we study the feasibility of passive computational RFID sensors for ambulatory monitoring. In particular, we focus on recognizing transfers out of beds or chairs and walking. Ideally, all these activities need to be monitored by movement sensor alarm systems to alert caregivers to provide supervision during the ambulation of older people in hospitals and nursing homes to prevent a fall. Our novel approach to partition continuous sensor data on natural activity boundaries and to identify transfers out of beds or chairs and walking as transitions between sequences of movements overcomes issues posed by the sparsity and the noise. We demonstrate through in-depth experiments the high performance (F-score > 93%) and the responsiveness of our approach.

Description: This paper describes a methodology to extract a consistent human settlement extent layer using Landsat data and its implementation in the Google Earth Engine platform. The approach allows the extraction of human settlement extents by means of the existing Landsat 5 and 7 data sets, allowing to check their evolution at 30-m spatial resolution. Since human settlements are the main proxy to people geographical distribution and to building locations, this layer may serve as a mean to disaggregate people/building counts at the regional/national level. The approach is tested in several parts of the world against existing ground truth data at the same spatial resolution in Brazil and China, as well as against extents manually extracted from VHR data in three different geographical areas: 1) Brazil; 2) South East China; and 3) Indonesia.

Description: Remote sensing of urban areas is mainly conducted at high frequencies, to obtain highly resolved images for classification, target detection, or urban areas monitoring for instance. We propose on the contrary to investigate the use of VHF-band for observation, between 120 and 360 MHz. In particular, our concern is to allow target detection, when the object is not in the line of sight (LOS) of the radar, which is typically an issue in urban areas. The benefits of low frequencies are highligted using measurements and simulations over a simple metallic model of two buildings surrounding a street.

Description: A common-mode (CM) active filter was designed in a compact package to suppress CM conducted emissions at a switching mode power supply (SMPS). Based on the analytical expressions considering both stability and performance, the design and optimization rules for the proposed active filter have been presented. After verifying its performance by measurements using vector network analysis, the proposed filter was installed in a 200-W SMPS board with 64 and 110 kHz switching frequencies, demonstrating its usefulness by experiments. The performance degradation due to the magnetic saturation and the AEF grounding impedance was also analyzed and investigated.

Description: This paper proposes an approach to design multiple-input multiple-output radar waveforms that are orthogonal on both the transmitter and receiver. The proposed method jointly utilizes the direct sequence spread spectrum coding and orthogonal frequency division multiplexing (OFDM) chirp signaling techniques. We name it spread spectrum-coded OFDM chirp waveform diversity design. The performance of the designed waveforms is analyzed by examining the ambiguity function and correlation function. The influences of the spread spectrum code choice and the OFDM chirp parameters are also investigated. It is verified that the proposed design scheme can ensure these waveforms stay orthogonal on the receiver and have large time-bandwidth product which is beneficial to separate closely spaced targets.

Description: Studies have presented that the driver vigilance level has serious implication in the causation of road accidents. This paper focuses on integrating both the vehicle-based control behavior and physiological state to predict the driver vigilance index which is evaluated by using a smartwatch. The vehicle control behavior can be observed from the steering wheel movement. Our study utilized the smartwatch motion sensors to study the steering wheel behavior. Meanwhile, physiological state of driver reflects the driver capability of safety alert driving which is estimated by photoplethysmogram (PPG) and respiration signals in this paper. The PPG sensor is integrated in a sport wristband with a Bluetooth low energy module, transmitted the PPG signals to smartwatch in real time. The steering angle is derived by the reading from smartwatch built-in accelerometer and gyroscope sensors. On the other hand, the respiration is derived using the PPG peak baseline method. In order to utterly investigate the sleepiness-induced factors, the time, spectral, and phase space domain features are calculated. Considering the smartwatch processing capability, mutual-information technique is applied to designate the ten most descriptive features. Then, the extracted descriptive features are serve as parameters to a classifier to determine the driver aptitude status. The features are analyzed for their correlation with the subjective Koralinska sleepiness scale and through recorded video observations. The experimental results reveal that our system is capable of estimating driver hypervigilance at average of 96.5% accuracy rate by evaluating on both driving behavior and driver physiological state, provided a novel and low-cost implementation.

Description: A cavitating two-phase flow of water in a pipe with area shrinkage was experimentally investigated, acquiring at high sampling rate pressure signals and images of the cavitating flow field. The time series of the pressure fluctuations was analyzed in terms of power spectral density and related to the cavitation regimes. Furthermore, the fluctuations of the pressure measurements were also decomposed using the wavelet transform to analyze the frequency distribution of the signals energy with respect to the flow behavior. The energy content at each frequency band of the acquire signals is well related to cavitation flow-field behavior. Moreover, the artificial neural network and the least squares support vector machine (LS-SVM) were implemented to identify the cavitation regime, using, as inputs, the power spectral density distributions of the pressure fluctuations, and some features of the decomposed signals, as the wavelet energy for each decomposition level and wavelet entropy. Results indicate the most accurate model to be used in the cavitation regime identification, underlining the enhanced capability of LS-SVM trained with the input data set based on the wavelet decomposition features.