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  • Books  (1,278)
  • bic Book Industry Communication::M Medicine  (907)
  • TA1-2040  (373)
  • MDPI - Multidisciplinary Digital Publishing Institute  (955)
  • Frontiers Media SA  (323)
  • Presses universitaires de Rennes
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  • Books  (1,278)
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  • 1
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: This book is comprised of important reviews and cutting-edge original research papers concerning electrospun and electrosprayed formulations in drug delivery. Electrospinning and electrospraying have, in recent years, attracted increasing attention in the pharmaceutical sector, with research in the area advancing rapidly. It is now possible to prepare extremely complex systems using multi-fluid processes, and to increase production rates to an industrial scale. Electrospun formulations can be produced under GMP conditions and are in clinical trials. In this volume, we explore a range of topics around electrospinning and electrospraying in controlled drug delivery. Four reviews cover the exciting potential of cyclodextrin-containing fibers and the many potential biomedical applications of electrospun fibers. The use of electrospinning to prepare amorphous systems and improve the dissolution rate and solubility of poorly soluble active ingredients is addressed, and the possibilities of such materials in tissue engineering are comprehensively covered. The six original research papers cover the effect of molecular properties on API release from Eudragit-based electrospun fibers; ferulic acid solid dispersions; electrospun medicines to treat psoriasis; scale up of electrospinning and its use to produce low-dose tablets; transepithelial permeation of drugs released from electrospun fibers, and the possibilities for the synergistic chemophotothermal treatment of cancer.
    Keywords: R5-920 ; RM1-950 ; tissue engineering ; cyclodextrin ; permeability ; poly (vinylpyrrolidone-co-vinyl acetate) ; crystalline ; antibacterial ; drug delivery ; homogenization ; capsaicin ; combination therapy ; high-shear mixing ; cyclodextrin-inclusion complexes ; amorphous ; high-speed electrospinning ; PMVE/MA ; aqueous solubility enhancement ; sieve analysis ; Raman mapping ; Eudragit ; nanofibers ; psoriasis ; PCL ; essential oils ; parameters ; antibiotics ; xanthan gum ; carvedilol ; amorphous composite ; coaxial electrospinning ; insoluble drug ; NIR-triggered drug release ; fast dissolution ; electrospinning ; oral drug delivery ; electrospun nanofibers ; poly-cyclodextrin ; TRPV1 ; gallic acid ; solid dispersion ; photothermal therapy ; drug release ; applications ; bic Book Industry Communication::M Medicine
    Language: English
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  • 2
    Publication Date: 2023-12-21
    Description: Fluid intake has barely been assessed, and hydration status has only rarely been measured in epidemiological studies. This hampers attempts to assess the adequacy of water intake at a population level. However, although guidelines have been established to determine how much water humans require to avoid dehydration and to optimize physical and psychological function, limited data are available on the total water and beverages intake. Therefore, the percentage of population with inadequate water intake is unknown. There is a clear need for studies in different settings around the world that quantify total water and beverage intake and explore associations between types of beverages consumed and energy intake.
    Keywords: R5-920 ; Adequate hydration ; Beverages consumption ; Water and energy intake ; bic Book Industry Communication::M Medicine
    Language: English
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  • 3
    Publication Date: 2024-04-11
    Description: It has become more evident that many microalgae respond very differently than land plants to diverse stimuli. Therefore, we cannot reduce microalgae biology to what we have learned from land plants biology. However, we are still at the beginning of a comprehensive understanding of microalgae biology. Microalgae have been posited several times as prime candidates for the development of sustainable energy platforms, making thus the in-depth understanding of their biological features an important objective. Thus, the knowledge related to the basics of microalgae biology must be acquired and shared rapidly, fostering the development of potential applications. Microalgae biology has been studied for more than forty years now and more intensely since the 1970’s, when genetics and molecular biology approaches were integrated into the research programs. Recently, studies on the molecular physiology of microalgae have provided evidences on the particularities of these organisms, mainly in model species, such as Chlamydomonas reinhardtii. Of note, cellular responses in microalgae produce very interesting phenotypes, such as high lipid content in nitrogen deprived cells, increased protein content in cells under high CO2 concentrations, the modification of flagella structure and motility in basal body mutant strains, the different ancient proteins that microalgae uses to dissipate the harmful excess of light energy, the hydrogen production in cells under sulfur deprivation, to mention just a few. Moreover, several research groups are using high-throughput and data-driven technologies, including “omics” approaches to investigate microalgae cellular responses at a system-wide level, revealing new features of microalgae biology, highlighting differences between microalgae and land plants. It has been amazing to observe the efforts towards the development and optimization of new technologies required for the proper study of microalgae, including methods that opened new paths to the investigation of important processes such as regulatory mechanisms, signaling crosstalk, chemotactic mechanisms, light responses, chloroplast controlled mechanisms, among others. This is an exciting moment in microalgae research when novel data are been produced and applied by research groups from different areas, such as bioprocesses and biotechnology. Moreover, there has been an increased amount of research groups focused in the study of microalgae as a sustainable source for bioremediation, synthesis of bioproducts and development of bioenergy. Innovative strategies are combining the knowledge of basic sciences on microalgae into their applied processes, resulting in the progression of many applications that hopefully, will achieve the necessary degree of optimization for economically feasible large-scale applications. Advances on the areas of basic microalgae biology and novelties on the essential cellular processes were revealed. Progress in the applied science showed the use of the basic science knowledge into fostering translational research, proposing novel strategies for a sustainable world scenario. In this present e-book, articles presented by research groups from different scientific areas showed, successfully, the increased development of the microalgae research. Herewith, you will find articles ranging from bioprospecting regional microalgae species, through advances in microalgae molecular physiology to the development of techniques for characterization of biomass and the use of biomass into agriculture and bioenergy production. This e-book is an excellent source of knowledge for those working with microalgae basic and applied sciences, and a great opportunity for researchers from both areas to have an overview of the amazing possibilities we have for building an environmentally sustainable future once the knowledge is translated into novel applications.
    Keywords: TA1-2040 ; TP248.13-248.65 ; QK1-989 ; Q1-390 ; Biotechnology ; biomass ; Hydrogen ; bioenergy ; Nutrients ; Lipids ; Microalgae ; Biofuels ; sustainability ; Carbon Dioxide ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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  • 4
    Publication Date: 2023-12-21
    Description: It is now well appreciated that the immune system, in addition to its traditional role in defending the organism against pathogens, communicate in a well-organized fashion with the brain to maintain homeostasis and regulate a set of neural functions. Perturbation in this brain-immune interactions due to inflammatory responses may lead to psychiatric and neurological disorders. Microglia are one of the essential cells involved in the brain-immune interactions. Microglial cells are now not simply regarded as resident tissue macrophages in the brain. These cells are derived from myeloid progenitor cells in the yolk sac in early gestation, travel to the brain parenchyma and interact actively with neurons during the critical period of neurogenesis. Microglia provide a trophic support to developing neurons and take part in the neural wiring through the activity-dependent synapse elimination via direct neuron-microglia interactions. Altered microglial functions including changes in the gene expression due to early life inflammatory events or psychological and environmental stressors can be causally related to neurodevelopmental diseases and mental health disorders. This type of alterations in the neural functions can occur in the absence of infiltration of inflammatory cells in the brain parenchyma or leptomeninges. In this sense, the pathogenetic state underlying a significant part of psychiatric and neurological diseases may be similar to “para-inflammation”, an intermediate state between homeostatic and classical inflammatory states as defined by Ruslan Medzhitov (Nature 454:428-35, 2008). Therefore, it is important to study how systemic inflammation affects brain health and how local peripheral inflammation induces changes in the brain microenvironment. Chronic pain is also induced by disturbance in otherwise well-organized multisystem interplay comprising of reciprocal neural, endocrine and immune interactions. Especially, early-life insults including exposure to immune challenges can alter the neuroanatomical components of nociception, which induces altered pain response later in life. Recently the discrete roles of microglia and blood monocyte-derived macrophages are being defined. The distinction may be further highlighted by disorders in which the brain parenchymal tissue is damaged. Therefore, studies investigating the dynamics of immune cells in traumatic brain injury and neurotropic viral infections including human immunodeficiency virus, etc. as well as neurodegenerative diseases such as amyotrophic lateral sclerosis are promising to clarify the interplay between the central nervous and immune systems. The understanding of the histological architecture providing the infrastructure of such neuro-immune interplay is also essential. This Frontiers research topic brings together fourteen articles and aims to create a platform for researchers in the field of psychoneuroimmunology to share the recent theories, hypotheses and future perspectives regarding open questions on the mechanisms of cell-cell interactions with chemical mediators among the nervous, immune and endocrine systems. We hope that this platform would reveal the relevance of the studies on multisystem interactions to enhance the understanding of the mechanisms underlying a wide variety of neurological and psychiatric disorders.
    Keywords: R5-920 ; RC346-429 ; RC581-607 ; brain-immune interaction ; fatigue ; pain ; HIV ; neuroinflammation ; traumatic brain injury ; depression ; microglia ; amyotrophic lateral sclerosis ; autism ; bic Book Industry Communication::M Medicine
    Language: English
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  • 5
    Publication Date: 2023-12-21
    Description: Poly-ADP ribose polymerase (PARP) proteins are critical mediators of DNA repair. Many traditional anti-cancer chemotherapy agents overwhelm a cell’s ability to repair DNA damage in order to kill proliferating malignant cells. Recent evidence suggests that cancers within and across tissue types have specific defects in DNA repair pathways, and that these defects may predispose for sensitivity and resistance to various classes of cytotoxic agents. Breast, ovarian and other cancers develop in the setting of inherited DNA repair deficiency, and these cancers may be more sensitive to cytotoxic agents that induce DNA strand breaks, as well as to inhibitors of PARP activity. A series of recent clinical trials has tested whether PARP inhibitors can achieve synthetic lethality in hereditary DNA repair-deficient tumors. At the current time, mutation of BRCA serves as a potential, but not comprehensive, biomarker to predict response to PARP inhibitor therapy. Mechanisms of resistance to PARP inhibitors are only recently being uncovered. Future studies seek to identify sporadic cancers that harbor genomic instability rendering susceptibility to PARP inhibitors that compound lethal DNA damage.
    Keywords: R5-920 ; RC254-282 ; DNA reapir ; PARP inhibitor ; Homologous Recombination ; combination therapy ; DNA Damage ; Cancer ; bic Book Industry Communication::M Medicine
    Language: English
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  • 6
    Publication Date: 2023-12-21
    Description: This e-book provides the insight into occupational health and safety problems, challenges and solutions of the dairy sector. Thirty-two authors have been sharing their results and knowledge reflecting the challenges from small scale farming up to industrial style. The worldwide trend of growing farm sizes and a reduction in numbers is one of the major drivers for the changes in the working environment. Musculoskeletal disorders are among the most prevalent health problems of people working on farms. Nevertheless mechanisation has not reduced the number of complaints, and new problems arise due to the changing working environment.
    Keywords: R5-920 ; RA1-1270 ; immigrant workers ; Dairy farming ; OHS ; MSS ; MSD ; bic Book Industry Communication::M Medicine
    Language: English
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  • 7
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: Gluten is the major protein of wheat and other cereals (rye and barley); it is responsible for triggering celiac disease (CD) in genetically predisposed individuals. Until a few years ago, CD was the major (if not the only) well-known gluten-related disorder. However, in recent years, it has become clear that gluten proteins may activate different pathological mechanisms, leading to a wide spectrum of human diseases, including non-celiac gluten sensitivity (NCGS), gluten ataxia, neuro-psychiatric disorders, and many others. Conceptually, we have therefore moved from a Ptolemaic to a Copernican system, i.e., CD is no longer the “center of the universe”, but is just one of the possible worlds of gluten intolerance. Many other gluten planets do indeed exist and deserve the attention of researchers and clinicians alike. Although different gluten-related disorders show specific epidemiological, pathophysiological, and clinical aspects, these conditions share a trigger and treatment: the gluten-free diet. For a very long time, awareness of these disorders has been limited and, therefore, the epidemiology of gluten-related disorders is still a “work in progress”. Current research strives to clarify the boundaries between these entities, their disease mechanisms, and how a proper diagnosis can be implemented.
    Keywords: R5-920 ; gluten-related disorders;celiac disease;gluten intolerance ; bic Book Industry Communication::M Medicine
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  • 8
    Publication Date: 2023-12-21
    Description: Microglia are essential for the development and function of the adult brain. Their ontogeny, together with the absence of turnover from the periphery and the singular environment of the central nervous system (CNS), make microglia a unique cell population compared to other tissue-macrophages. The unique properties and functions of microglial cells, such as their role in synaptic pruning or the exceptional capacity to scan the brain parenchyma and rapidly react to its perturbations, have emerged in recent years. In the coming years, understanding how microglia acquire and maintain their unique profiles in order to fulfil distinct tasks in the healthy CNS and how these are altered in disease, will be essential to develop strategies to diagnose or treat CNS disorders with an immunological component. This Research Topic covers several aspects of microglial biology, ranging from their origin and the functional role of microglia during development and lifespan, their molecular properties compared with other brain and peripheral immune cells to microglial phenotypes and functional states in neurodegenerative diseases and brain tumours. In conclusion, the present Research Topic provides a comprehensive overview of our current understanding of several cellular and molecular mechanisms that make microglia a unique immune cell population within the healthy CNS as well as under inflammatory, neurodegenerative and tumorigenic processes.
    Keywords: R5-920 ; RC346-429 ; RC581-607 ; inflammation ; brain tumour ; neurodegeneration ; microglia ; ontogeny ; bic Book Industry Communication::M Medicine
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  • 9
    Publication Date: 2023-12-21
    Description: The non-classical HLA class I molecule HLA-G is different from classical HLA class I molecules because of the low polymorphism in the coding region, the fact that HLA-G primary transcript is alternatively spliced in seven isoforms, and the inhibitory action on immune cells. Although HLA-G is low polymorphic, variants in both promoter and 3’ un-translated region (UTR) of HLA-G locus regulate its expression. In healthy conditions, a basal level of HLA-G gene transcription is observed in most cells and tissues; however, translation into HLA-G protein is restricted to trophoblasts in the placenta, where it participates in promoting tolerance at the fetal-maternal interface. HLA-G is also expressed by thymic epitelial, cornea, mesenchymal stem cells, nail matrix, pancreatic beta cells, erythroid, and endothelial precursors. HLA-G can be neo-expressed in adult tissues in pathological conditions, and its expression has been documented autoimmune disorders, viral infections, and cancer. In the latter setting de novo HLA-G expression is associated with the capability of tumor cells to evade the immune control. In the last decade it has become evident that HLA-G expression on T cells and antigenpresenting cells confers to these cells tolerogenic properties. This Research Topic focused on i) summarizing updated clinical and immunological evidences that HLA-G expression is associate with beneficial or detrimental tolerance, ii) gathering new insights into the mechanisms governing the expression of HLA-G in healthy and pathological conditions, such as pre-eclampsia, and iii) examining the mechanisms underlying HLA-G mediated tolerance.
    Keywords: R5-920 ; RC581-607 ; Pregnancy ; Autoimmunity ; Immuno-modulation ; Pre-Eclampsia ; Infections ; Exosomes ; HLA-G ; polymorphisms ; tolerance ; Cancer ; bic Book Industry Communication::M Medicine
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  • 10
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Non-Newtonian (non-linear) fluids are common in nature, for example, in mud and honey, but also in many chemical, biological, food, pharmaceutical, and personal care processing industries. This Special Issue of Fluids is dedicated to the recent advances in the mathematical and physical modeling of non-linear fluids with industrial applications, especially those concerned with CFD studies. These fluids include traditional non-Newtonian fluid models, electro- or magneto-rheological fluids, granular materials, slurries, drilling fluids, polymers, blood and other biofluids, mixtures of fluids and particles, etc.
    Keywords: TA1-2040 ; T1-995 ; Poiseuille–Couette flow ; membrane ; viscous fluid ; channel flow ; existence theorem ; yield stress ; hemoglobe capacitor ; creeping flows ; viscoplastic fluids ; projection method ; power-law fluid ; first- and second-order slip ; Mittag–Leffler ; lubrication ; viscoplastic fluid ; rupture ; convection ; Re numbers ; enhanced oil recovery (EOR) ; SPH-FEM ; Gamma densitometer ; oil recovery ; non-newtonian fluids ; marginal function ; particle interaction ; computational fluid dynamics ; non-isothermal flows ; suspensions ; Brinkman equation ; lubrication approximation (76A05 ; lid-driven cavity ; smoothed particle hydrodynamics (SPH) ; 76D08 ; Phan-Thien–Tanner (PTT) model ; bubble suspension ; porous media ; non-equilibrium thermodynamics ; porous medium ; suspension viscosity ; hemoglobin ; convection-diffusion ; slug translational velocity ; closure relationship ; non-linear fluids ; wormlike micellar solutions (WMS) ; high viscosity oil ; viscoelastic surfactants (VES) ; 76A20) ; meshless ; Bingham fluid ; Reynolds equation ; generalised simplified PTT ; dense suspension ; chemical EOR (cEOR) ; buoyancy force ; viscosity ratio ; aspect ratio ; rheology ; lubrication approximation ; fluid-solid interaction (FSI) ; optimal control ; natural convection ; biofluids ; shear-dependent viscosity ; thermodynamic capacitor ; shear-thinning ; stokesian dynamics ; weak solution ; biological capacitor ; cement ; variable viscosity ; Couette flow ; pressure boundary conditions ; inhomogeneous fluids ; boundary control ; similarity transformation ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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  • 11
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: The development of solid state gas sensors based on microtransducers and nanostructured sensing materials is the key point in the design of portable measurement systems able to reach sensing and identification performance comparable with analytical ones. In such a context several efforts must be spent of course in the development of the sensing material, but also in the choice of the transducer mechanism and its structure, in the electrical characterization of the performance and in the design of suitable measurement setups. This call for papers invites researchers worldwide to report about their novel results on the most recent advances and overview in design and measurements for applications in gas sensors, along with their relevant features and technological aspects. Original research papers are welcome (but not limited) on all aspects that focus on the most recent advances in: (i) basic principles and modeling of gas and VOCs sensors; (ii) new gas sensor principles and technologies; (iii) Characterization and measurements methodologies; (iv) transduction and sampling systems; (vi) package optimization; (vi) gas sensor based systems and applications.
    Keywords: TA1-2040 ; T1-995 ; indium oxide ; n/a ; environmental monitoring ; semiconductor ; gas sensor ; packed gas chromatographic column ; ultrathin carbon layer ; metal-oxide-semiconductor array sensor ; halitosis ; laser ablation ; capacitive micromachined ultrasonic transducers (CMUT) ; LTCC side via ; MEMS ; indirect packaging ; gas sensing ; efficiency ; bad breath ; electrospray ; array optimization ; low temperature co-fired ceramic (LTCC) ; electronic nose ; UV irradiation ; core/shell nanostructure ; combinatorial and high-throughput technique ; sensitive material ; hydrogen sulfide ; CO detection ; ZnO ; amperometric ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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  • 12
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-01-05
    Description: Advancements in digital technologies are reshaping the world of dentistry, from prosthodontics to implant dentistry. Intraoral scanners, facial scanners, 3D printers, and milling machines have revolutionized the clinical approach and operative workflow in daily practice. However, digital dentistry brings several challenges to clinicians due to the rapid evolution of new technologies and the lack of evidence-based guidelines for their correct use. The aim of this Special Issue is to cover the latest advances in the development and application of digital technologies in prosthetic and implant dentistry. We wish to provide both clinicians and researchers with a comprehensive and up-to-date source of information on current trends, limitations, and potential future applications of digital technologies in daily clinical practice.
    Keywords: dental implants ; digital impression ; intraoral scanner ; CAD/CAM materials ; toothbrushing wear ; surface ; roughness ; surface integrity ; alveolar remodeling ; tooth extraction ; intraoral digital scanning ; imaging superimposition ; less traumatic surgery ; socket healing ; implantology ; computer-aided surgery ; image-guided surgery ; zygomatic implants ; navigation system ; dental implant ; bone level ; prospective study ; sub-crestal placement ; emergence profile ; guided surgery ; digital workflow ; stereolithographic surgical guide ; accuracy ; CAD–CAM ; DICOM–STL ; static guided surgery ; clinical study ; intraoral scanners ; digital dentistry ; impression techniques ; full-arch impression ; elderly population ; dimensional measurement accuracy ; implant scan ; operator ; precision ; scan area ; trueness ; occlusion ; overloading ; complications ; implant-supported restorations ; marginal bone loss ; oral implantology ; intraoral scan ; cone-beam computed tomography ; oral surgery ; emergence angle ; retrospective study ; bic Book Industry Communication::M Medicine
    Language: English
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  • 13
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: On 11 March 2020, the World Health Organization declared COVID-19 a global pandemic, and the disease now affects nearly every country and region. Nearly 18 months later, COVID-19, caused by SARS-CoV-2, continues to present significant challenges to health systems, public health, and the economy of countries across both hemispheres. The morbidity and mortality of the infection caused by SARS-CoV-2 has been significant, and various waves of disease outbreaks initially overwhelmed hospitals and clinics in many countries and continue to do so. This influences everyone, and public health countermeasures have been dramatic in terms of their impact on employment, social systems, and mental health. This Special Issue collection follows on from the Special Issue “COVID-19: Current Challenges and Future Perspectives” and provides an avenue for authors from various disciplines to provide feedback on the response to and our future global preparedness for COVID-19, as well as to disseminate critical information about SARS-CoV-2 and the associated COVID-19 pandemic.
    Keywords: COVID-19 ; new-onset DM ; severe infection ; mortality ; outbreak ; P.1 variant ; Gamma variant ; SARS-CoV-2 infection ; whole-genome sequencing ; pandemic ; overweight ; obesity ; Peru ; psychological impacts ; public health ; preparedness ; mRNA-1273 ; BNT162b2 ; TAK-919 ; SARS-CoV-2 ; post-vaccination ; healthcare personnel ; vaccination ; asymptomatic infection ; HIV ; infectious disease ; excess mortality ; regdanvimab ; remdesivir ; severe ; community transmission ; population density gradient ; Dhaka ; Bangladesh ; dengue ; undifferentiated febrile illness ; antigen testing ; variants ; reinfections ; breakthrough infections ; vaccine hesitancy ; sub-Saharan Africa ; pulmonary fibrosis ; postacute COVID-19 syndrome ; tuberculosis ; helminth coinfection ; coronavirus ; coordination ; health operations and technical expertise ; AFRO ; diarrhea ; liver ; pancreas ; inflammatory bowel diseases ; liver transplantation ; reproduction rate ; phylogenetic analysis ; clade GK ; D614G ; P681R ; cross-reactivity ; haemorrhage ; thrombocytopenia ; thrombosis ; severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) ; molecular diagnostics ; real-time polymerase chain reaction (RT-qPCR) ; economy ; income levels ; waves ; policy ; turning points ; occupational exposure ; risk factors ; personal protective equipment ; SIR model ; socio-behavioral aspects ; interaction distance ; school reopening strategy ; self-medication ; over-the-counter ; medicine use ; Pakistan ; clinical features ; Luanda ; Angola ; socioeconomic status ; risk perception ; risk prevention practices ; qualitative ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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  • 14
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: Epilepsy is one of the most prevalent neurological disorders and is characterized by recurrent seizures resulting from abnormal neuronal excitability in the central nervous system. Despite the availability of thirty-six antiseizure medications, about one-third of patients with epilepsy do not respond to the pharmacological treatment and develop a so-called “pharmaco-resistant epilepsy” or “refractory epilepsy.” Thus, there is an urgent need to develop novel, effective therapies based on novel mechanisms underlying neuronal excitability that leads to seizures. This reprint’s original research papers and review articles highlight unknown mechanisms underlying pharmaco-resistant resistant epilepsy, epileptogenesis, and seizure suppression.
    Keywords: 3CAI ; GRIA1 ; GRIA2 ; intractable epilepsy ; PICK1 ; protein kinase C ; pericytes ; mural cells ; cytokine ; blood-brain barrier ; neuroinflammation ; 3-phosphoinositide-dependent protein kinase-1 ; AKT ; cyclosporin A ; GluA1 ; GluR1 ; PDK1 ; refractory seizure ; temporal lobe epilepsy ; hippocampus ; 4-aminopyridine ; epilepsy model ; long-term potentiation ; AMPA receptor ; audiogenic epilepsy ; rodents ; fear reaction ; behavior genetics ; c-Fos ; early gene activation ; epileptogenesis ; lipopolysaccharide ; pentylenetetrazole ; post-traumatic epilepsy ; seizure susceptibility ; traumatic brain injury ; epilepsy ; ghrelin ; ghrelin receptor ; anxiety ; TRPV1 channels ; neuronal activity ; neuropsychiatric comorbidity ; immunofluorescence ; audiogenic kindling ; acoustically evoked seizures ; EACT ; generalized tonic-clonic seizures ; inherited epilepsy ; TMEM1A channels ; wild running seizures ; astrocyte ; ML365 ; pharmacoresistant epilepsy ; cortical atrophy ; hippocampal atrophy ; intracerebral electrode ; magnetic resonance imaging ; posttraumatic epilepsy ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 15
    Publication Date: 2023-12-21
    Description: Lymphocytes constantly survey the lymph nodes in search for potential infection by a pathogen. They enter the afferent lymphatic vessel that serves as a conduit to transport the motile lymphocytes to the draining lymph node. Lymphatic vessels (LVs) are present in most vascularized tissues. They are traditionally regarded as passive conduits for soluble antigens and leukocytes. Afferent LVs begin as blind ended capillaries, which give rise to collecting vessels that merge and connect with draining lymph nodes (dLNs). Initial lymphatic capillaries are composed of Lymphatic Endothelial Cells (LECs) connected by discontinuous cell junctions, which join to form larger collecting lymphatic vessels, and ultimately feed into the LN subcapsular sinus. Within the LN, LECs are localized to the subcapsular, cortical, and medullary sinuses, where they interact with incoming and exiting leukocytes. LECs, and in general LN stromal cells, have emerged in the recent years as active players in the immune response. In support to this,studies have shown that the immune response generated during inflammation and under pathologic conditions is accompanied by modeling of the LVs and generation of new lymphatics, a process known as lymphangiogenesis. These facts strongly suggest that LECs and stromal LN cells in general, are not inert players but rather are part of the immune response by organizing immune cells movement, exchanging information and supplying survival factors. The purpose of this research topic is to review the role of the LECs during immune homeostasis and cancer. Considering the critical role of lymphangiogenesis in many pathologies like chronic and acute inflammation, autoimmunity, wound healing, graft rejection, and tumor metastasis, it is important to understand the molecular mechanisms that govern the cross talks between the LECs and immune cells during homeostasis and inflammation.
    Keywords: R5-920 ; RC581-607 ; Liver Injury ; Lymphatic Vessels ; Lymphatic Vasculature ; Tumor Microenvironment ; PD-L1 ; Antigen Presenting Cells ; Lymphatic Endothelial Cells ; T cell trafficking ; T cells ; bic Book Industry Communication::M Medicine
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  • 16
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: Development of strategies to assist the movement of poorly permeable molecules across biological barriers has long been the goal of drug delivery science. In the last three decades, there has been an exponential increase in advanced drug delivery systems that aim to address this issue. However, most proprietary delivery technologies that have progressed to clinical development are based on permeation enhancers (PEs) that have a history of safe use in man. This Special Issue entitled “Transmucosal Absorption Enhancers in the Drug Delivery Field” aims to present the current state-of-the-art in the application of PEs to improve drug absorption. Emphasis is placed on identification of novel permeation enhancers, mechanisms of barrier alteration, physicochemical properties of PEs that contribute to optimal enhancement action, new delivery models to assess PEs, studies assessing safety of PEs, approaches to assist translation of PEs into effective oral, nasal, ocular and vaginal dosage forms and combining PEs with other delivery strategies.
    Keywords: R5-920 ; RM1-950 ; chitosan ; intestinal epithelial cells ; ocular delivery ; amphiphilic polymers ; cornea ; tight junction modulator ; cyclodextrin ; permeability ; gemini surfactant ; transferrin ; compound 48/80 ; epithelial permeability ; cervicovaginal tumors ; nanoparticles ; confocal laser scanning microscopy ; safety ; formulation ; salcaprozate sodium ; intestinal absorption ; FITC-dextran ; curcumin ; block copolymers ; nasal vaccination ; whole leaf ; brush border ; ocular drug delivery ; vaccine adjuvant ; nanoparticle ; nasal delivery ; efflux ; permeation enhancers ; absorption enhancers ; nose to brain delivery ; small intestine ; epithelium ; CNS disorders ; absorption modifying excipients ; insulin ; absorption enhancer ; gel ; intestinal delivery ; thermogel system ; Caco-2 ; biocompatibility studies ; absorption enhancement ; man ; PN159 ; poorly absorbed drug ; tryptophan ; tight junction ; oral macromolecule delivery ; penetration enhancer ; intestinal permeation enhancers ; nanocrystals ; simvastatin ; nanomedicine ; enterocyte ; N-dodecyl-?-D-maltoside (DDM) ; cell-penetrating peptide ; quaternization ; KLAL ; nasal ; nasal permeability ; transmucosal drug delivery ; Caco-2 cells ; mast cell activator ; penetration enhancers ; drug delivery ; nose-to-brain ; bioenhancer ; polymeric micelles ; mucoadhesion ; cell-penetrating peptide (CPP) ; simulated intestinal fluid ; vaginal delivery ; nasal formulation ; pharmacokinetic interaction ; sodium caprate ; clinical trial ; transmucosal permeation ; drug absorption enhancer ; sugar-based surfactants ; nanocapsules ; imatinib ; teriparatide ; osteoporosis ; hydrophobization ; F-actin ; combined microsphere ; transepithelial electrical resistance ; oral delivery ; ocular conditions ; metabolism ; antimicrobial peptide ; permeation enhancer ; drug administration ; antiepileptic drug ; amino acid ; in vivo studies ; sodium cholate (NaC) ; epithelial transport ; preclinical ; nose to brain transport ; pharmacokinetics ; chitosan derivatives ; ophthalmology ; tight junctions ; sheep ; cationic functionalization ; GLP-1 ; pulmonary ; and liposome ; cytochrome P450 ; claudin ; P-glycoprotein ; in situ hydrogel ; mucoadhesiveness ; PTH 1-34 ; Aloe vera ; oral peptides ; bic Book Industry Communication::M Medicine
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  • 17
    Publication Date: 2024-04-11
    Description: This Special Issue covers symmetry and asymmetry phenomena occurring in real-life problems. We invited authors to submit their theoretical or experimental research presenting engineering and economic problem solution models dealing with the symmetry or asymmetry of different types of information. The issue gained interest in the research community and received many submissions. After rigorous scientific evaluation by editors and reviewers, nine papers were accepted and published. The authors proposed different MADM and MODM solution models as integrated tools to find a balance between the components of sustainable global development, to find a symmetry axis concerning goals, risks, and constraints to cope with the complicated problems. Most approaches suggested decision models under uncertainty, combining the usual decision-making methods with interval-valued fuzzy or rough sets theory, also Z numbers. The application fields of the proposed models involved both problems of technological sciences and social sciences. The papers cover three essential areas: engineering, economy, and management. We hope that a summary of the Special Issue as provided here will encourage a detailed analysis of the papers included in the Printed Edition.
    Keywords: TA1-2040 ; T1-995 ; rough sets ; interval type-2 fuzzy set (IT2FS) ; resources distribution ; the criteria of the weights ; public management ; Step-wise Weight Assessment Ratio Analysis (SWARA) ; multi-criteria decision-making (MCDM) ; symmetry of the method ; quadcopter ; transaction cost ; full fuzzy environment ; dual generalized geometric Bonferroni mean (DGGBM) operator ; data logger ; information theory ; control system ; salvage value ; nonlinear dynamics ; pattern formation ; oscillations ; stability ; Pythagorean fuzzy set ; FAHP ; fuzzy sets ; group decision-making ; generalized Bonferroni mean (GBM) operator ; probabilistic systems analysis ; economic decisions ; 2-tuple linguistic neutrosophic numbers set (2TLNNSs) ; evaluating the quality of distant courses ; subjective weights ; Z-numbers ; green supplier selection ; dual generalized Bonferroni mean (DGBM) operator ; normal cloud ; thrust ; sensor ; neutrosophic numbers ; MCDM ; Bayes’ theorem ; optimal dividend ; logistics ; measurement ; hybrid MCDM ; combining the weights ; data envelopment analysis ; criteria weights ; multiple attribute decision making (MADM) ; IDOCRIW ; excess-of-loss reinsurance ; fuzzy efficiency ; multiple-criteria decision-making (MCDM) ; MCGDM ; transport ; backward cloud transformation ; engineering problems ; rough ARAS ; capital injection ; performance ; Bonferroni mean (BM) operator ; green supply chain management ; population sizes ; hybrid problem solution models ; criteria weight assessment ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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  • 18
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: The proliferation of powerful but cheap devices, together with the availability of a plethora of wireless technologies, has pushed for the spread of the Wireless Internet of Things (WIoT), which is typically much more heterogeneous, dynamic, and general-purpose if compared with the traditional IoT. The WIoT is characterized by the dynamic interaction of traditional infrastructure-side devices, e.g., sensors and actuators, provided by municipalities in Smart City infrastructures, and other portable and more opportunistic ones, such as mobile smartphones, opportunistically integrated to dynamically extend and enhance the WIoT environment. A key enabler of this vision is the advancement of software and middleware technologies in various mobile-related sectors, ranging from the effective synergic management of wireless communications to mobility/adaptivity support in operating systems and differentiated integration and management of devices with heterogeneous capabilities in middleware, from horizontal support to crowdsourcing in different application domains to dynamic offloading to cloud resources, only to mention a few. The book presents state-of-the-art contributions in the articulated WIoT area by providing novel insights about the development and adoption of middleware solutions to enable the WIoT vision in a wide spectrum of heterogeneous scenarios, ranging from industrial environments to educational devices. The presented solutions provide readers with differentiated point of views, by demonstrating how the WIoT vision can be applied to several aspects of our daily life in a pervasive manner.
    Keywords: TA1-2040 ; T1-995 ; container ; fog computing ; virtual reality ; privacy and security ; software defined infrastructure ; intelligent medical service ; very long instruction word (VLIW) ; semantics ; privacy leakage detection ; context information ; post-copy ; ontology ; body area network ; DSP ; Internet-of-Things ; Mobile Device Management ; interoperability ; Android ; water consumption ; Processing-in-Memory ; performance analysis ; semantic ; mobility ; data management ; CRIU ; training simulator ; Industry 4.0 ; sensor networks ; experimental evaluation ; programming paradigm ; pre-copy ; microservice-oriented platform ; CubeSats ; middleware ; registry ; smart metering ; big data analytics ; nanosatellites ; medium access control ; Internet of Things ; heterogeneity ; web-of-things ; one-to-one computing educational program ; Web-of-Things ; internet of things ; instruction set extension ; microservices architecture ; migration ; behaviour ; wireless access networks ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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  • 19
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: Currently, cancer is the second leading cause of death worldwide and is the most complex and challenging disease known to humankind. Due to the complex underlying mechanisms of tumorigenesis and tumor metastasis, as well as the intrinsic limitations of conventional cancer therapies, the effective treatment of cancer remains a great challenge. Novel therapeutic strategies with superior anticancer ability urgently need to be discovered. In recent years, nano-drug delivery systems have been extensively investigated and applied as alternatives to conventional cancer treatments. Cancer nanomedicines aim to achieve the targeted delivery of chemotherapeutic drugs to the tumor site, utilizing strategies such as passive targeting, active targeting and stimuli-triggered drug release, while simultaneously decreasing drug accumulation in normal tissues, which together lead to improved therapeutic efficacy and reduced side effects. Currently, several cancer nanomedicines are in regular use, and several others are in various stages of development.This Special Issue will highlight recent progress in the development of novel nanomedicines and targeted drug delivery systems for cancer therapy.
    Keywords: graphene quantum dot ; targeted drug delivery ; photothermal therapy ; chemo-therapy ; polymeric prodrug ; theranostic nanocomplex ; pH-triggering releasing ; magnetic targeting ; magnetic hyperthermia ; magnetic resonance imaging ; docetaxel ; adenosine receptors ; PLGA ; nanoparticles ; lung cancer ; Notch signaling ; RBPJ protein ; drug repurposing ; fidaxomicin ; acarbose ; schaftoside ; breast cancer ; experimental skin cancer ; entrapment efficacy ; ethosomes ; metformin ; in vitro permeation ; zeta potential ; sesamol ; albumin nanoparticles ; doxorubicin ; oxidative stress ; antioxidants ; tumor-derived membrane vesicles ; cancer therapy ; tumor vaccine ; personalized immunotherapy ; low-density lipoprotein ; nanoparticle ; tumor microenvironment-responsive ; magnetic nanofluid ; improved magnetic resonance imaging ; neutral-responsive Fenton reaction ; enhanced chemodynamic therapy ; brain targeting ; folate receptor ; glioma cancer ; erlotinib ; blood–brain barrier ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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  • 20
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Research on radiation-tolerant electronics has increased rapidly over the past few years, resulting in many interesting approaches to modeling radiation effects and designing radiation-hardened integrated circuits and embedded systems. This research is strongly driven by the growing need for radiation-hardened electronics for space applications, high-energy physics experiments such as those on the Large Hadron Collider at CERN, and many terrestrial nuclear applications including nuclear energy and nuclear safety. With the progressive scaling of integrated circuit technologies and the growing complexity of electronic systems, their susceptibility to ionizing radiation has raised many exciting challenges, which are expected to drive research in the coming decade. In this book we highlight recent breakthroughs in the study of radiation effects in advanced semiconductor devices, as well as in high-performance analog, mixed signal, RF, and digital integrated circuits. We also focus on advances in embedded radiation hardening in both FPGA and microcontroller systems and apply radiation-hardened embedded systems for cryptography and image processing, targeting space applications.
    Keywords: TA1-2040 ; TK1-9971 ; T1-995 ; single event effects ; n/a ; radiation-hardening-by-design (RHBD) ; frequency divider by two ; single event upset ; Image processing ; CMOS analog integrated circuits ; FPGA ; total ionizing dose (TID) ; Impulse Sensitive Function ; soft error ; hardening by design ; radiation hardening by design ; X-rays ; Single-Event Upsets (SEUs) ; line buffer ; heavy ions ; VHDL ; FPGA-based digital controller ; radiation hardening by design (RHBD) ; radiation hardening ; SRAM-based FPGA ; proton irradiation ; ring oscillator ; sensor readout IC ; fault tolerance ; space application ; physical unclonable function ; voltage controlled oscillator (VCO) ; Ring Oscillators ; analog single-event transient (ASET) ; single event opset (SEU) ; SEB ; single event upsets ; bipolar transistor ; total ionizing dose ; protons ; triple modular redundancy (TMR) ; gain degradation ; space electronics ; saturation effect ; configuration memory ; Co-60 gamma radiation ; total ionization dose (TID) ; frequency synthesizers ; CMOS ; PLL ; TDC ; single-event upsets (SEUs) ; bandgap voltage reference (BGR) ; 4MR ; single-shot ; error rates ; Radiation Hardening by Design ; soft errors ; heavy-ions ; single-event effects (SEE) ; single event transient (SET) ; SEE testing ; proton irradiation effects ; RFIC ; single event upset (SEU) ; FMR ; ionization ; radiation tolerant ; triplex–duplex ; neutron irradiation effects ; digital integrated circuits ; single event gate rupture (SEGR) ; power MOSFETs ; ring-oscillator ; selective hardening ; voltage reference ; nuclear fusion ; TMR ; gamma-rays ; gamma ray ; instrumentation amplifier ; radiation effects ; reference circuits ; radiation-hardened ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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  • 21
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Smart sensors are technologies designed to facilitate the monitoring operations. For instance, power consumption can be minimized through on-board processing and smart interrogation algorithms, and state detection enhanced through collaboration between sensor nodes. Applied to structural health monitoring, smart sensors are key enablers of sparse and dense sensor networks capable of monitoring full-scale structures and components. They are also critical in empowering operators with decision making capabilities. The objective of this Special Issue is to generate discussions on the latest advances in research on smart sensing technologies for structural health monitoring applications, with a focus on decision-enabling systems. This Special Issue covers a wide range of related topics such as innovative sensors and sensing technologies for crack, displacement, and sudden event monitoring, sensor optimization, and novel sensor data processing algorithms for damage and defect detection, operational modal analysis, and system identification of a wide variety of structures (bridges, transmission line towers, high-speed trains, masonry light houses, etc.).
    Keywords: TA1-2040 ; T1-995 ; NSGA-II ; wind force ; wavelet packet decomposition ; structural health monitoring ; amplitude spectrum ; environmental noise ; patch antenna ; damage identification ; event-triggered sensing ; Particle Swarm Optimization (PSO) algorithm ; high-speed train ; low-velocity impacts ; concrete structures ; sensors distribution optimization ; acceleration ; digital sampling moiré ; crack ; displacement sensor ; length effect ; FBG sensor array ; SHM ; space window ; Bayesian blind source separation ; feature selection ; stress detection ; wheel minor defect ; strain ; uniaxial stress measurement ; turbine ; impact identification ; helical antenna ; energy analysis of wavelet band ; strain wave ; time window ; structural steel members ; steel frame ; acoustoelastic effect ; demand-based nodes ; online wayside detection ; sensor ; bridge ; sensitivity ; acoustic emission ; bending stiffness ; wireless smart sensors ; distributed dense sensor network ; mapping construction ; data fusion ; fuzzy classification ; shear-wave birefringence ; normal mode ; piezoelectric wafer active sensors ; resonant frequency ; electromagnetic oscillation ; settlement ; sensor optimization ; modal frequencies ; perturbation theory ; feature extraction ; Virtual Distortion Method (VDM) ; reflective optical sensor ; fibre bundle ; smartphones ; crack identification ; active sensing ; test vehicle ; calibration ; stretching method ; model updating ; rotary ultrasonic array ; 2D crack growth ; data processing ; damage detection ; impactor stiffness ; tip clearance ; transmission tower ; phase spectrum ; concrete crack ; structural impact monitoring ; shaking table tests ; optical crack growth sensor ; steel strand ; passive sensing ; sudden event monitoring ; aero engine ; principal component analysis ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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  • 22
    Publication Date: 2023-12-21
    Description: It is long known that many cells can shed extracellular vesicles, small membrane-enclosed cell fragments. Although the existence of extracellular vesicles has been recognized for many years, researchers are only beginning to understand their physiologic significance. Several recent studies have demonstrated that extracellular vesicles released from cells serve as a mode of cellular communication. They can carry diverse molecular payload (e.g. nucleic acids, bioactive lipids and proteins) to distal organs and recipient cells. Extracellular vesicles can be classified into three major groups: exosomes, microvesicles, and apoptotic bodies. All these types of extracellular vesicles can be found in a variety of biologic specimen and their numbers, distribution and composition may serve as biomarkers for various disorders, including cardiovascular disease. Although extracellular vesicle-mediated processes are currently best characterized in the fields of cancer biology and neurobiology, evidence is accumulating that extracellular vesicles play a key role in the pathophysiology of diabetes, thrombosis, inflammation and cardiovascular calcification. In this Research Topic, we invited review and methodological articles that advance our understanding of extracellular vesicle-related processes in vascular biology.
    Keywords: R5-920 ; Angiogenesis ; Atherosclerosis ; Extracellular vesicles ; Calcification ; Biomarkers ; Cardiovascular disease ; Inflammation ; Exosomes ; Platelets ; Heart valve ; bic Book Industry Communication::M Medicine
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  • 23
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: In this Special Issue, recent advancements in the field of pediatric tumors are discussed, and novel prognostic markers are critically appraised. Greater understanding of the heterogeneity of pediatric cancers will ultimately lead to new therapeutic strategies with the potential to provide new prospects for precision medicine in pediatric oncology.
    Keywords: undernutrition ; obesity ; nutritional status ; childhood cancer ; overall survival ; event-free survival ; relapse ; treatment-related toxicity ; review ; sarcoma botryoides ; fertility-sparing surgery ; embryonal rhabdomyosarcoma ; genital tract ; prognosis ; treatment ; local debulking ; neoadjuvant chemotherapy ; radiation ; ovarian cancer ; adolescents ; diagnosis ; therapy ; guidelines ; children ; papillary thyroid cancer ; proto-oncogene B-raf gene (BRAF) ; craniopharyngioma ; recurrence ; risk factors ; youth ; acute lymphoblastic leukemia (ALL) ; child ; genetics ; CDKN2A/2B deletions ; fluorescent in situ hybridization (FISH) ; multiple-ligation probe amplification (MLPA) ; copy-number alterations (CNAs) ; risk stratification ; minimal residual disease (MRD) ; cardiotoxicity ; chemotherapeutics agents ; biomarkers ; omics technology ; medulloblastoma ; tumor ; histologic ; pediatrics ; micro-RNAs ; non-coding RNAs ; molecular subgroup ; stratification ; acute lymphoblastic leukemia ; proteomics ; oncology ; chemotherapy ; cardiac function tests ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
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  • 24
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Mobile robotics is a challenging field with great potential. It covers disciplines including electrical engineering, mechanical engineering, computer science, cognitive science, and social science. It is essential to the design of automated robots, in combination with artificial intelligence, vision, and sensor technologies. Mobile robots are widely used for surveillance, guidance, transportation and entertainment tasks, as well as medical applications. This Special Issue intends to concentrate on recent developments concerning mobile robots and the research surrounding them to enhance studies on the fundamental problems observed in the robots. Various multidisciplinary approaches and integrative contributions including navigation, learning and adaptation, networked system, biologically inspired robots and cognitive methods are welcome contributions to this Special Issue, both from a research and an application perspective.
    Keywords: TA1-2040 ; T1-995 ; similarity measure ; swarm-robotics ; drag-based system ; PID algorithm ; human–robot interaction ; behaviour dynamics ; state constraints ; fair optimisation ; micro mobile robot ; robot ; actuators ; high-gain observer ; turning model LIP ; space robot ; manipulation action sequences ; subgoal graphs ; remotely operated vehicle ; constrained motion ; joint limit avoidance ; curvilinear obstacle ; rehabilitation system ; stability criterion ; system design ; quad-tilt rotor ; iterative learning ; spiral curve ; cable detection ; SEA ; douglas–peuker polygonal approximation ; predictable trajectory planning ; ATEX ; obstacle avoidance system ; kinematic singularity ; collision avoidance ; biologically-inspired ; jumping robot ; differential wheeled robot ; design and modeling ; control efficacy ; robotics ; extremum-seeking ; object-oriented ; non-holonomic mobile robot ; magneto-rheological fluids ; rendezvous consensus ; altitude controller ; master-slave ; switching control ; deep reinforcement learning ; mechanism ; expansion logic strategy ; negative buoyancy ; action generation ; radial basis function neural networks ; unmanned aerial vehicles ; extend procedure ; glass façade cleaning robot ; convolutional neural network ; climbing robot ; micro air vehicle ; car-like kinematics ; variable speed ; machine learning ; dynamical model ; transportation ; geodesic ; unmanned surface vessel ; medical devices ; stopper ; extended state observer (ESO) ; high efficiency ; object mapping ; multi-objective optimization ; hybrid robot ; robot learning ; auto-tuning ; cable disturbance modeling ; manipulation planning ; pesticide application ; high-speed target ; sparse pose adjustment (SPA) ; service robot ; lumped parameter method ; Geometric Algebra ; dynamic coupling analysis ; Thau observer ; tri-tilt-rotor ; industrial robotic manipulator ; hardware-in-the-loop simulation ; robotic drilling ; muscle activities ; small size ; chameleon ; continuous hopping ; wall climbing robot ; hover mode ; 3D-SLAM ; curvature constraints ; PSO ; drilling end-effector ; Rodrigues parameters ; gait adaptation ; static environments ; position/force cooperative control ; snake-like robot ; shape-fitting ; powered exoskeleton ; input saturation ; kinematic identification ; methane ; human–machine interactive navigation ; q-learning ; path following ; hopping robot ; mobile manipulation ; high step-up ratio ; actuatorless ; monocular vision ; stability analysis ; compact driving unit ; snake robot ; non-holonomic robot ; curvature constraint ; phase-shifting ; dialytic elimination ; gesture recognition ; snake robots ; series elastic actuator ; flapping ; servo valve ; motion camouflage control ; biomimetic robot ; minimally invasive surgery robot ; centralized architecture ; trajectory planning ; computing time ; adaptive control law ; kinematics ; facial and gender recognition ; single actuator ; victim-detection ; shape memory alloys ; undiscovered sensor values ; discomfort ; Differential Evolution ; numerical evaluation ; quadruped robot ; coverage path planning ; localization ; MPC ; n/a ; fault diagnosis ; neural networks ; disturbance-rejection control ; sample gathering problem ; cart ; bio-inspired robot ; opposite angle-based exact cell decomposition ; optimization ; safety ; goal exchange ; hierarchical planning ; ocean current ; robot motion ; nonlinear differentiator ; mapping ; finite-time currents observer ; Newton iteration ; inverse kinematics ; deposition uniformity ; spatial pyramid pooling ; hierarchical path planning ; end effector ; head-raising ; fault recovery ; LOS ; path tracking ; non-inertial reference frame ; step climbing ; obstacle avoidance ; sliding mode control ; symmetrical adaptive variable impedance ; lane change ; quadcopter UAV ; singularity analysis ; biped mechanism ; fault-tolerant control ; dynamic neural networks ; mobile robots ; data association ; UAV ; enemy avoidance ; reinforcement learning ; grip optimization ; safety recovery mechanism ; exoskeleton ; dynamic environment ; uncertain environments ; hybrid bionic robot ; potential field ; robot navigation ; cleaning robot ; unmanned aerial vehicle ; non-singular fast-terminal sliding-mode control ; contact planning ; Lyapunov-like function ; piezoelectric actuator ; transition mode ; non-prehensile manipulation ; multiple mobile robots ; Tetris-inspired ; real-time action recognition ; integral line-of-sight ; topological map ; alpine ski ; target tracking ; closed-loop detection ; working efficiency ; mathematical modeling ; curve fitting ; force control ; biped robots ; NSGA-II ; mobile robot ; load carriage ; prescription map translation ; artificial fish swarm algorithm ; Q-networks ; self-reconfigurable robot ; G3-continuity ; autonomous vehicle ; loop closure detection ; excellent driver model ; robots ; graph representation ; regional growth ; target assignment ; evolutionary operators ; intelligent mobile robot ; motion sensor ; exploration ; droplets penetrability ; dynamic uncertainty ; simultaneous localization and mapping (SLAM) ; area decomposition ; multi-criteria decision making ; 4WS4WD vehicle ; biped climbing robots ; skiing robot ; ROS ; decision making ; smart materials ; centrifugal force ; missile control system ; formation of robots ; electro-rheological fluids ; pneumatics ; variable spray ; inertial measurement unit (IMU) ; Robot Operating System ; trajectory interpolation ; formation control ; immersion and invariance ; dragonfly ; parallel navigation ; harmonic potential field ; pallet transportation ; mobile robot navigation ; negative-buoyancy ; grip planning ; manipulator ; position control ; external disturbance ; legged robot ; passive skiing turn ; autonomous underwater vehicle (AUV) ; gait cycle ; path planning ; sliding mode observer ; dynamic gait ; self-learning ; polyomino tiling theory ; coalmine ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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  • 25
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-03-21
    Description: Recently, the development of polymeric materials for biomedical applications has advanced significantly. Polymeric materials are favored in the development of therapeutic devices, including temporary implants and three-dimensional scaffolds for tissue engineering and in vitro disease modelling.Further advancements have also occurred in the utilization of polymeric materials for pharmacological applications, such as delivery vehicles for drug release.We would like to invite you to contribute to this Special Issue. Research topics of interest include, but are not limited to, recent advances related to 3D cell culture, biomaterials, tissue engineering, disease modelling, hydrogel, organoids, drug discovery, bioimaging, cardio-renal, metabolic disease, and stem cell biology.
    Keywords: hydrogels ; crosslinking ; degradable ; gamma (γ)-irradiation ; sterilization ; sterility assurance ; antibacterial ability ; jojoba ; Simmondsia ; chemistry ; liquid wax ; biology ; toxicity ; pharmaceutical/industrial uses ; articular cartilage ; mechanical properties ; tribological properties ; antibacterial ; pathogens ; infectious diseases ; silver nanoparticles ; wound care ; wound dressings ; polymers ; gelatin ; nanofibers ; sponges ; Ag/RGO nanocomposites ; green preparation ; anticancer performance ; potential mechanism ; oxidative stress ; hydrogel ; poloxamer 407 polymer ; poloxamer 407 gel ; transungual drug delivery ; onychomycosis ; ungual penetration enhancer ; Terbinafine ; diafiltration ; SAXS ; aromatic interactions ; poly(sodium 4-styrenesulfonate) ; chlorpheniramine ; polyelectrolyte ; aggregation ; coaxial electrospinning ; extracellular matrix ; myelination ; oligodendrocyte ; water-soluble materials ; orthokeratology lens ; protein deposition ; optical characteristics ; rubbing ; chitosan ; kenaf ; nanocrystalline cellulose ; platelet lysate ; wound healing ; carbohydrate polymers blends ; functional food ; antioxidant activity ; co-microencapsulation ; spray drying ; bacteria viability (Bacillus clausii) ; probiotics ; itraconazole ; self-emulsifying nanovesicles ; transungual ; anti-fungal ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::K Economics, finance, business & management::KN Industry & industrial studies::KND Manufacturing industries::KNDP Pharmaceutical industries
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  • 26
    Publication Date: 2023-12-21
    Description: Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is widely used in the treatment of haematological malignancies as a form of immunotherapy acting through a graft-versus-leukemia (GvL) reaction. This curative allogeneic response can be associated with severe drawbacks, such as frequent and severe graft-versus-host disease (GvHD) and a long-lasting immunodeficiency, especially now with the development of innovative strategies such as umbilical cord blood transplantation or transplants from haplo-identical family donors (Haplo-HSCT). In the long-term follow-up of these patients, severe post-transplant infections, relapse or secondary malignancies may be directly related to persistent immune defects.Reconstitution of the different lymphocyte populations (B, T, NK, NKT) and antigen presenting cells of myeloid origin (monocytes, macrophages and dendritic cells) should be considered not only quantitatively but especially qualitatively, in terms of functional subsets. Immune deficiency leading to an increased susceptibility to infections lasts for more than a year. Although infections that occur in the first month mostly result from a deficiency in both granulocytes and mononuclear cells (MNC), later post-engraftment infections are due to a deficiency in MNC subsets, primarily CD4 T-cells and B-cells. T-cell reconstitution has been extensively studied because of the central role of T-cells in mediating both GvHD, evidenced by the reduced incidence of this complication following T-Cell depletion, and a GvL effect as shown by DLI. In the recent years there has been renewed interest in the role of NK-cells, especially in the context of Haplo-HSCT, and in B-cell reconstitution.This Frontiers Research Topic will provide state of the art knowledge of the mechanisms of immune reconstitution in an allogeneic environment, in order to improve monitoring and therapeutic intervention in allo-HSCT patients.
    Keywords: R5-920 ; RC581-607 ; cell therapy ; Immune reconstitution ; Haplo-SCT ; HSCT ; Thymic function ; bic Book Industry Communication::M Medicine
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  • 27
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: This Special Issue gathers research from different branches of science and engineering disciplines working on experiments and modelling of nanocomposites into one volume. The Guest Editor welcomes papers dedicated to experimental, computational, and theoretical aspects dealing with many important state-of-the-art technologies and methodologies regarding the synthesis, fabrication, characterization, properties, design, and applications, and both finite element analysis and molecular dynamic simulations, of nanocomposite materials and structures. Full papers covering novel topics, extending the frontiers of the science and technology of nanoreinforced composites are encouraged. Reviews covering topics of major interest will be also considered.
    Keywords: TA1-2040 ; T1-995 ; ab initio ; critical yield strength ; carbon nanotube ; impact buckling ; elasticity ; molecular dynamics simulation ; magnetism ; coarse-grained model ; 3D fiber-metal laminates ; mechanical property ; interface ; nanocomposites ; interface force fields ; YN ; graphene/Fe composite ; cohesive element ; stability ; ScN ; delamination propagation ; interfaces ; graphene nanoplatelets ; nanoindentation ; pressure ; molecular dynamics ; piezoelectric property ; temperature effect ; Fe-Al ; hardness ; equivalent fiber ; disorder ; Fe3Al ; elastic modulus ; delamination buckling ; CNT agglomeration ; CNTs/epoxy nanocomposites ; boron nitride honeycomb ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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  • 28
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-05-06
    Description: This e-book summarises the latest advances in the rheumatic diseases with a focus on the recent efforts of vascular and pulmonary manifestations and anticipate the new and future directions of these research topic. Rheumatic diseases represent a heterogeneous group of severe autoimmune disorders. The present Special Issue aims to provide an overview of the complexity of vascular and pulmonary manifestations of rheumatologic diseases and helps in knowledge to manage them. The eleven published articles here collected underline the complexity of rheumatic diseases and the difficult to treated them. The manuscripts provide an overview of the pathophysiology and current treatment regimes of these disorders, highlighting tools which assist with diagnosis, risk stratification and therapy. Finally, we underline the importance of a multidisciplinary team working using the skills of clinicians, radiologists, and pathologists.
    Keywords: systemic sclerosis ; scleroderma ; interstitial lung disease ; pulmonary function tests ; high-resolution computed tomography ; rheumatic ; pulmonary arterial hypertension ; targeted therapy ; systemic lupus erythematosus ; airway disease ; shrinking lung syndrome ; diffuse alveolar hemorrhage ; pleurisy ; infection ; cardiopulmonary exercise testing ; osteopontin ; connective tissue diseases ; pulmonary involvement ; microvascular involvement ; nailfold capillaroscopy ; rheumatoid arthritis ; interstitial lung diseases ; CX3CL1/fractalkine ; CX3CR1 ; M1 macrophage ; M2 macrophage ; SKG mice ; heart failure ; 3D-echocardiography ; ventricular function ; outcome ; ventricular-arterial coupling ; antifibrotic agents ; COVID-19 ; IPF ; progressive fibrosing ILD ; UIP ; pharmacological interactions ; fibromyalgia ; gastrointestinal symptoms ; probiotic ; VSL#3® ; efficacy ; tolerability ; polymyalgia rheumatica ; vagus nerve stimulation ; inflammatory response ; PMR ; t-vns ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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  • 29
    Publication Date: 2023-12-21
    Description: Gamma/delta (γδ) T-cells are a small subset of T-lymphocytes in the peripheral circulation but constitute a major T-cell population at other anatomical localizations such as the epithelial tissues. In contrast to conventional a/ß T-cells, the available number of germline genes coding for T-cell receptor (TCR) variable elements of γδ T-cells is very small. Moreover, there is a prefential localization of γδ T-cells expressing given Vgamma and Vdelta genes in certain tissues. In humans, γδ T-cells expressing the Vg9Vd2-encoded TCR account for anywhere between 50 and 〉95% of peripheral blood γδ T-cells, whereas cells expressing non-Vd2 genes dominate in mucosal tissues. In mice, there is an ordered appearance of γδ T-cell „waves“ during embryonic development, resulting in preferential localization of γδ T-cells expressing distinct VgammaVdelta genes in the skin, the reproductive organs, or gut epithelia. The major function of γδ T-cells resides in local immunosurveillance and immune defense against infection and malignancy. This is supported by the identification of ligands that are selectively recognized by the γδ TCR. As an example, human Vgamma9Vdelta2 T-cells recognize phosphorylated metabolites („phosphoantigens“) that are secreted by many pathogens but can also be overproduced by tumor cells, providing a basis for a role of these γδ T-cells in both anti-infective and anti-tumor immunity. Similarly, the recognition of endothelial protein C receptor by human non-Vdelta2 γδ T-cells has recently been identified to provide a link for the role for such γδ T-cells in immunity against epithelial tumor cells and cytomegalovirus-infected endothelial cells. In addition to „classical“ functions such as cytokine production and cytotoxicity, recent studies suggest that subsets of γδ T-cells can exert additional functions such as regulatory activity and – quite surpisingly – „professional“ antigen-presenting capacity. It is currently not well known how this tremendous extent of functional plasticity is regulated and what is the extent of γδ TCR ligand diversity. Due to their non-MHC-restricted recognition of unusual stress-associated ligands, γδ T-cells have raised great interest as to their potential translational application in cell-based immunotherapy. Topics of this Research Focus include: Molecular insights into the activation and differentiation requirements of γδ T-cells, role of pyrophosphates and butyrophilin molecules for the activation of human γδ T-cells, role of γδ T-cells in tumor immunity and in other infectious and non-infectious diseases, and many others. We are most grateful to all colleagues who agreed to write a manuscript. Thanks to their contributions, this E-book presents an up-to-date overview on many facets of the still exciting γδ T-cells.
    Keywords: R5-920 ; RC581-607 ; Infection ; Butyrophilin 3A1 ; Tumor-infiltrating lymphocytes ; cancer immunotherapy ; IL-17 ; Pyrophosphates ; bic Book Industry Communication::M Medicine
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  • 30
    Publication Date: 2024-04-11
    Description: The specialty section Earthquake Engineering is one branch of Frontiers in Built Environment and welcomes critical and in-depth submissions on earthquake ground motions and their effects on buildings and infrastructures. Manuscripts should yield new insights and ultimately contribute to a safer and more reliable design of building structures and infrastructures. The scope includes the characterization of earthquake ground motions (e.g. near-fault, far-fault, short-period, long-period), their underlying properties, their intrinsic relationship with structural responses, and the true behaviors of building structures and infrastructures under risky and uncertain ground motions. More specific topics include recorded ground motions, generated ground motions, response spectra, stochastic modeling of ground motion, critical excitation, geotechnical aspects, soil mechanics, soil liquefaction, soil-structure interactions, pile foundations, earthquake input energy, structural control, passive control, active control, base-isolation, steel structures, reinforced concrete structures, wood structures, building retrofit, structural optimization, uncertainty analysis, robustness analysis, and redundancy analysis. This eBook includes four original research papers, in addition to the Specialty Grand Challenge article, on the critical earthquake response of elastic-plastic structures under near-fault or long-duration ground motions which were published in the specialty section Earthquake Engineering. In the early stage of dynamic nonlinear response analysis of structures around 1960s, a simple hysteretic structural model and a simple sinusoidal earthquake ground motion input were dealt with together with random inputs. The steady-state response was tackled by an equivalent linearization method developed by Caughey, Iwan and others. In fact, the resonance plays a key role in the earthquake-resistant design and it has a strong effect even in case of near-fault ground motions. In order to draw the steady-state response curve and investigate the resonant property, two kinds of repetition have to be introduced. One is a cycle, for one forced input frequency, of the initial guess of the steady-state response amplitude, the construction of the equivalent linear model, the analysis of the steady-state response amplitude using the equivalent linear model and the update of the equivalent linear model based on the computed steady-state response amplitude. The other is the sweeping over a range of forced input frequencies. This process is quite tedious. Four original research papers included in this eBook propose a new approach to overcome this difficulty. Kojima and Takewaki demonstrated that the elastic-plastic response as continuation of free-vibrations under impulse input can be derived in a closed form by a sophisticated energy approach without solving directly the equations of motion as differential equations. While, as pointed out above, the approach based on the equivalent linearization method requires the repetition of application of the linearized equations, the method by Kojima and Takewaki does not need any repetition. The double impulse, triple impulse and multiple impulses enable us to describe directly the critical timing of impulses (resonant frequency) which is not easy for the sinusoidal and other inputs without a repetitive procedure. It is important to note that, while most of the previous methods employ the equivalent linearization of the structural model with the input unchanged, the method treated in this eBook transforms the input into a series of impulses with the structural model unchanged. This characteristic guarantees high accuracy and reliability even in the large plastic deformation range. The approach presented in this eBook is an epoch-making accomplishment to open the door for simpler and deeper understanding of structural reliability of built environments in the elastic-plastic range.
    Keywords: TA1-2040 ; fling-step input ; Critical response ; Long-duration ground motion ; double impulse ; forward-directivity input ; triple impulse ; robustness ; Near-fault ground motion ; Ground motion ; Ductility factor ; uncertainty ; resonance ; Structural parameter ; Earthquake Response ; Elastic-plastic response ; Interval analysis ; Multiple impulse ; Earthquake input energy ; redundancy ; Upper bound of input energy ; earthquake engineering ; critical excitation method ; Energy transfer function ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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  • 31
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-06-21
    Description: With the development of analytical instruments, the academic system has become more complicated, producing new journals one after another. Therefore, it became much important to clarify what is original of “Medicines”. As the name Medicines indicates, it includes science and practice of caring for a patient and managing the diagnosis, prognosis, prevention, treatment or palliation of their injury or disease. Therefore, Medicines differs from other journals with similar title in that it covers a wide range of fields, from traditional medicine to rapidly developing molecular-targeted drugs, focusing on their pharmacological effects, structure–activity relationships, metabolic pathways, gene expression, using cultured cells, animals, and clinical trials. Most parts of this Special Issue were written by our editorial board members, who described the research topics and how they are engaged in their field of research. All of these articles are their life-long story. We collected a total number of 22 original works by basic researchers and clinical doctors. We hope that readers can get a chance to know the current status of diverse fields of medicines, and what your most important research themes are after reading these articles.
    Keywords: Hedychium ; traditional medicine ; coronarin D ; villosin ; anti-acetylcholinesterase ; antidiabetic ; anti-inflammatory ; antimicrobial ; antioxidant ; antitumor ; Genista tridentata ; Pterospartum tridentatum ; isoflavones ; flavonols ; genistein ; biochanin A ; rutin ; daidzein ; inflammatory bowel disease ; Crohn’s disease ; ulcerative colitis ; extra-intestinal manifestations ; orofacial granulomatosis ; tag-like lesions ; cobblestoning ; mucogingivitis ; lip swelling ; aphthous stomatitis ; Angelicae Sinensis Radix ; Danggui ; granules ; herb ; multivariate analysis ; ultra-performance liquid chromatography ; Tai Chi ; qigong ; immune system ; immunity ; inflammation ; telemedicine ; remote monitoring ; GER-e-TEC ; elderly patient ; artificial intelligence ; geriatric syndromes ; detection of the precursory signs of decompensation of geriatric syndromes ; renal cell cancer ; genomic landscape ; targeted therapy ; tumor evolution ; tumor heterogeneity ; allergic rhinitis ; quercetin ; human CD4+ T cells ; Th1/Th2 cytokine balance ; modulation ; in vitro ; intravascular catheter ; CRBSI ; biofilm ; CVC ; antifouling ; chromone ; tumor specificity ; QSAR analysis ; apoptosis ; cell cycle analysis ; contrast-enhanced ultrasound ; hepatocellular carcinoma ; LI-RADS ; chronic liver disease ; granuloma annulare ; granulomatous disorders of the skin ; inflammatory skin conditions ; medical dermatology ; biliary tract cancer ; cholangiocarcinoma ; PARP ; BRCA ; olaparib ; rucaparib ; liver cancer ; pancreatic adenocarcinoma ; pancreatic cancer ; sarcoidosis ; superior vena cava syndrome ; venous thrombosis ; RUCAM ; Roussel Uclaf Causality Assessment Method ; diagnostic algorithm ; iDILI ; iDrug induced liver injury ; DILI ; HILI ; herb induced liver injury ; Stachys L. ; traditional uses ; pharmacological activities ; phytochemicals ; bioactive compounds ; Kampo formulae ; alkaline extract of Sasa sp. ; pine cone extract ; povidone-iodine ; HSV ; HIV ; loss of infectivity ; solubilization method ; diaphragmatic breathing ; abdominal breathing ; breathing exercise ; systematic review ; randomized controlled trial ; respiratory function ; auricular acupuncture ; preoperative anxiety ; protocol ; randomized controlled trials ; meta-analysis ; boiogito ; knee osteoarthritis ; rat ; Yokukansan ; fentanyl ; transient receptor potential ankyrin 1 (TRPA1) channel ; phosphorylated extracellular signal-regulated kinase (pERK) ; whole-cell patch-clamp recording ; herbal medicine ; calcium metabolism ; bone metabolism ; protease ; osteoclast ; macrophage ; RANKL ; LPS ; TLR4 ; TREM2 ; bic Book Industry Communication::M Medicine
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  • 32
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: This book is a collection of recent publications from researchers all over the globe in the broad area of high-voltage engineering. The presented research papers cover both experimental and simulation studies, with a focus on topics related to insulation monitoring using state-of-the-art sensors and advanced machine learning algorithms. Special attention was given in the Special Issue to partial discharge monitoring as one of the most important techniques in insulation condition assessment. Moreover, this Special Issue contains several articles which focus on different modeling techniques that help researchers to better evaluate the condition of insulation systems. Different power system assets are addressed in this book, including transformers, outdoor insulators, underground cables, and gas-insulated substations.
    Keywords: TA1-2040 ; T1-995 ; artificial neural network ; simulation ; high-frequency ; artificial flashover tests ; wide bandgap power modules ; tracking ; electrical field strength ; fast-rise square wave voltages ; FDTD simulation ; cable joint ; corona discharge ; feature selection ; post insulator ; earthing systems ; wind speed ; surface discharge ; oil/paper insulation ; oil-paper insulation ; high-magnitude currents and impulse polarity ; UFVM ; Tettex 9520 ; electrical tree ; flashover characteristics ; composite insulator ; partial discharge ; numerical modeling ; saline mechanism ; thermal parameters ; space charge density ; seasonal ; ion flow field ; denoising ; DDX 9121b ; temperature ; transformer asset management ; cavity discharge ; space/interface charge ; insulation health index ; heat transfer model ; leakage current ; machine learning ; partial discharges (PD) ; RF signal ; flashover ; high impulse conditions ; grounding electrodes ; generalized finite difference time domain ; curve fitting ; grounding ; plasma discharge ; outdoor insulators ; flashover dynamic model ; wavelet transform ; degradation ; thermal properties ; bipolar charge transport model ; UHF sensor ; cable ; random walk theory ; tracking test setup ; GIL ; pressure ; modelling ; non-uniform pollution between windward and leeward sides ; calibrator ; secondary arc ; polymeric insulation ; optical-UHF integrated detection ; shoreline ; dry band arcing ; photoelectric fusion pattern ; DDX 8003 ; XLPE ; silicone gel ; partial discharge modeling ; electric field analysis ; NSCT ; electrode’s geometry ; gas ; Comsol Multiphysics ; fast-impulses ; laying modes ; ageing ; cable ampacity ; residual resistance formulation ; finite element analysis ; thermal effect ; hydrophobicity ; soil resistivity ; charge simulation method ; short-circuit discharge ; dry band formation ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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  • 33
    Publication Date: 2024-04-11
    Description: Energy systems worldwide are undergoing major transformation as a consequence of the transition towards the widespread use of clean and sustainable energy sources. Basically, this involves massive changes in technical and organizational levels together with tremendous technological upgrades in different sectors ranging from energy generation and transmission systems down to distribution systems. These actions generate huge science and engineering challenges and demands for expert knowledge in the field to create solutions for a sustainable energy system that is economically, environmentally, and socially viable while meeting high security requirements. This book covers these promising and dynamic areas of research and development, and presents contributions in sustainable energy systems planning, integration, and management. Moreover, the book elaborates on a variety of topics, ranging from design and planning of small- to large-scale energy systems to the operation and control of energy networks in different sectors, namely electricity, heat, ?and transport.
    Keywords: TA1-2040 ; T1-995 ; n/a ; Romanian coastal environment ; neural networks ; intermittent heating ; wind velocities ; time-space network ; optimal chiller loading (OCL) ; renewable energy ; pure electric buses ; mixed-integer non-linear programming problem (MINLP) ; control system ; FANP ; energy consumption ; load regulation ; energy ; smart box ; novel method ; smart logistics system ; multiple uncertainties ; non-intrusive load monitoring ; wind speed forecasting ; solid waste to energy plant ; uncertain cooling demand ; dual robust optimization ; Black Sea ; field test and numerical simulation ; electric power ; sustainable development ; multi-type bus operating organization ; cuckoo search algorithm ; vehicular emissions ; SWAN ; public transport ; product quality model ; MCDM ; TOPSIS ; heat transfer ; solar energy ; forecasting validity ; information gap decision theory (IGDT) ; photovoltaic systems ; configurations of internal wall ; ensemble empirical mode decomposition ; agricultural pruning ; hot summer and cold winter climate zone ; energy and environmental systems ; feature extraction ; information platform ; pruning biomass ; smart grid ; product usability testing ; meteorological variables ; fuzzy logic ; performance evaluation ; rural residential building ; threshold value of daily operation hours ; datacenter ; wave energy ; thermal comfort ; heat storage and release ; resampling ; risk aversion ; environment ; support vector machine ; internal coverings ; numerical models ; gradient descent ; renewable biomass energy ; demand response ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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  • 34
    Publication Date: 2023-12-21
    Description: Aflatoxins are a group of polyketide mycotoxins that are produced mainly by members of the genus Aspergillus. Production of these toxic secondary metabolites is closely related to fungal development (Keller et al., 2005; Jamali et al., 2012). Contamination of food, feed and agricultural commodities by aflatoxins poses enormous economic and serious health concerns because these chemicals are highly carcinogenic and can directly influence the structure of DNA. The resulting genetic defects can lead to fetal misdevelopment and miscarriages; aflatoxins are also known to suppress immune systems (Razzaghi-Abyaneh et al., 2013). In a global context, aflatoxin contamination is a constant concern between the 35N and 35S latitude where developing countries are mainly situated. With expanding boundaries of developing countries, aflatoxin contamination has become a persistent problem to those emerging areas (Shams-Ghahfarokhi et al., 2013). The continuing threat by aflatoxin contamination of food, feed and agricultural commodities to the world population has made aflatoxin research one of the most exciting and rapidly developing study areas of microbial toxins. The present research topic includes six review articles, three mini reviews and four original research articles. Contributors highlight current global health issues arising from aflatoxins and aflatoxigenic fungi and cover important aspects of aflatoxin research including contamination of crops, epidemiology, molecular biology and management strategies. Special attention is given to fungus-plant host interactions, biodiversity and biocontrol, sexual recombination in aflatoxigenic aspergilli, potential biomarkers for aflatoxin exposure in humans and safe storage programs.
    Keywords: R5-920 ; QR1-502 ; Q1-390 ; TX341-641 ; genetic diversity ; Public Health ; Aspergillus flavus ; Genomics ; MicroRNAs ; Fungus host interactions ; biological control ; aflatoxin ; agricultural crops ; bic Book Industry Communication::M Medicine
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  • 35
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-03-07
    Description: In this reprint, state-of-the-art research and review articles on emerging material systems for additive manufacturing (AM) are collected, with a focus on the process–structure–properties relationships. Additive manufacturing (AM) has grown and evolved rapidly in recent years. There are many exciting research and translational works in many areas of application, such as biomedical, aerospace and electronics. These advancements are typically coupled with materials development, which has resulted in more functionalities added to 3D-printed parts, such as multi-material fabrications and integration with machine learning or digital twins. Such enhancements in functionalities have enabled the evolution of AM from a rapid prototyping tool to an actual manufacturing solution. In this reprint, two reviews and thirteen original research articles are included to highlight the latest development in the field of materials science for AM.
    Keywords: titanium scaffolds ; 3D printing ; pore design ; selective laser melting ; lattice structures ; torsion ; design ; additive manufacturing ; functionally gradient lattice ; torsional stiffness ; energy absorption ; failure behavior ; ferritic steel ; heat treatment ; SLM ; nuclear application ; laser powder bed fusion ; solidification crack ; hot crack ; aluminum alloy powder ; EN AW-5083 ; AA5083 ; AlSi10Mg ; powder bed fusion ; metal matrix composites ; laser powder-bed fusion ; aluminum alloys ; reinforcement ; ceramic particulates ; grain refinement ; crystallographic texture ; mechanical properties ; laser-directed energy deposition ; melt pool ; process maps ; multi-fidelity Gaussian process ; Bayesian Optimization ; uncertainty quantification ; K418 alloy ; orientation ; phase ; microhardness ; color 3D printing ; penetration depth ; chromaticity ; image-based metric ; color reproduction ; Ti-24Nb-4Zr-8Sn ; titanium alloy ; biomedical engineering ; microstructure ; X-ray diffraction ; directed energy deposition ; shape-memory alloys ; joining of metals ; elemental powders ; 3D concrete printing (3DCP) ; hybrids ; geopolymer ; frost resistance ; UV radiation ; thermal conductivity ; surface finishing ; physical vapor deposition ; composites ; recycling ; polymer-matrix composites (PMCs) ; direct ink writing ; liquid deposition modeling ; glass fibers ; stainless steel ; AISI 316L ; AISI 630 (17-4PH) ; AISI 420 ; AISI 440C ; carbon content ; online monitoring ; electron beam melting ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
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  • 36
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: In Western countries, cancer is among the most frequent causes of death. Despite striking advances in cancer therapy, especially by the so called “targeted agents”, there is still an urgent need for new drugs in oncology. Hope comes from the marine environment, which is a rich source of natural compounds showing anti-cancer activity. To date, four marine cytotoxic substances, namely cytarabine, trabectidine, eribulin, and monomethyl auristatin E (as a drug-antibody conjugate named vedotin) have made it into clinical routine. Many more are in all phases of clinical testing, and a plethora of substances has already been examined for in vitro and in vivo activity. Interestingly, more and more precise research tools allow the dissection of the molecular mode of action of these cytotoxic substances, thereby uncovering the specific drug targets in cancer cells. This development will blur the edges between “targeted” and “untargeted” therapy, and will hopefully lead to a more directed use of cancer medicine (based on a molecular rationale of activity) in the future. This Topical Collection will cover the whole scope from agents with cancer-preventive activity, to novel and previously characterized compounds with anti-cancer activity, both in vitro and in vivo, and the latest status of clinical development from drug trials. Of note, compounds possessing pro-carcinogenic activity or mediating cancer cell survival are also within the scope of this Topical Collection. In addition, a special focus will be placed on current shortfalls and possible strategies to overcome obstacles in the area of marine anti-cancer drug development.
    Keywords: R5-920 ; toxicology ; marine toxins ; drug discovery ; marine natural compounds and their derivatives ; xenograft models ; drug combination ; cancer ; drug resistance ; cancer-preventive activity ; molecular effects ; molecular targets ; bic Book Industry Communication::M Medicine
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  • 37
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: Personalized medicine for Parkinson’s disease is a growing and emerging concept in light of recent recognition that Parkinson’s is a syndromic condition affecting multiple neurotransmitter systems, as well as brain and extracranial structures. The clinical expression is, thus, heterogeneous, and presentation age can range from the 30s to the 90s, with PD in older patients being associated with significant neuropathological comorbidity as well, involving not just misfolded alpha synuclein deposition but also amyloid and tau. Traditional and largely guideline-driven “one size fits all” management strategies adopted in clinical practice are, therefore, often inadequate in holistic management of a patient, particularly when aspects of motor and nonmotor symptoms are taken into consideration. In this supplement of JPM, we present a selection of papers which address several possible strands of personalized medicine in PD, ranging from genomic precision medicine to digital “checklists” to ensure delivery of holistic personalized medicine involving nonpharmacological strategies, as well. We are soliciting any papers addressing biomarkers, genetics and pharmacogenetics, treatment or complementary therapies for personalized or individualized treatment for PD.
    Keywords: Parkinson’s disease ; movement disorders ; periodontitis ; periodontal disease ; hematologic tests ; Vitamin D ; oral health ; Parkinson’s Disease ; cognition ; GABAergic signaling ; cerebellum ; MRS ; response inhibition ; non-motor symptoms ; carer stress ; older persons with Parkinson’s disease ; education ; lifestyle behaviours ; diet ; cross-sectional ; population study ; neurological disorders ; precision medicine ; genetics ; clinical trials ; Parkinson’s disease (PD) ; cognitive rehabilitation ; intervention ; deep brain stimulation ; levodopa-carbidopa intestinal gel ; apomorphine ; radiofrequency ; focused ultrasound ; induced pluripotent stem cells ; cell therapy ; gene therapy ; personalized medicine ; advanced Parkinson’s disease (APD) ; apomorphine subcutaneous infusion therapy ; pain ; intrajejunal ; levodopa ; motor and non-motor symptoms ; PKG (KinetiGrap) ; rehabilitation ; device-aided therapies ; personalised medicine ; Alzheimer’s disease ; clinical trial ; impulsive-compulsive disorders (ICD) ; dopaminergic therapy ; genetic markers ; pharmacogenetic ; polymorphisms ; insomnia ; sleep quality ; assessment ; young onset Parkinson’s (YOPD) ; Emiratis ; expatriate ; genetic ; epigenetics ; societal impact ; device aided therapies ; quality of life ; non motor symptoms ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJN Neurology & clinical neurophysiology
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  • 38
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: In the urological sphere, the number of tumor malignancies caused by cancer is continuously growing in Western countries. Although this is mainly due to the contemporary increase in the life expectancy of people in these geographic areas, many other factors are also contributing to this growth. Urological cancer is a complex and varied disease which affects different organs and mainly affects the male population. In fact, in most statistics, kidney, prostate, and bladder cancer are regularly included in the top-ten list of the most frequent neoplasms in males. The female population, however, has also been increasingly affected by renal and bladder cancer in the last decade. From these facts, it is clear that urological cancer is a problem of major concern in developed societies. This Topic Issue of Cancers intends to shed some light on the complexity of this field and will consider all useful and appropriate contributions from scientists and clinicians in order to improve urological cancer knowledge for patients’ benefit.
    Keywords: high-risk prostate cancer ; androgen receptor axis ; castration resistance ; neuroendocrine carcinoma ; PARP inhibition ; immunotherapy ; cancer genome ; precision targeting ; robot-assisted partial nephrectomy ; renal cell carcinoma ; indocyanine green ; nephron sparing ; prostate cancer survivors ; follow-up care ; primary health care ; general practice ; process evaluation ; Consolidated Framework for Implementation Research ; prostate-specific membrane antigen positron-emission tomography ; multiparametric magnetic-resonance imaging ; primary diagnosis ; prostate cancer ; systematic review ; diagnosis ; PSMA ; PSA ; tumor ; PET scan ; bladder cancer ; bisphenol A ; bisphenol S ; energy metabolism ; migration ; proliferation ; carbon-ion radiotherapy ; elderly patients ; radiotherapy ; particle beam therapy ; life expectancy ; systemic immune-inflammation index ; Charlson comorbidity index ; CAPRA-S ; early survival ; male incontinence ; robotic prostatectomy ; clear cell renal cell carcinoma ; ferroptosis ; prognostic model ; TCGA ; E-MTAB-1980 ; GLS2 ; pazopanib ; real-world data ; non-interventional study ; time on drug ; nivolumab ; everolimus ; trial-eligibility ; ureteral neoplasms ; urinary bladder neoplasms ; ureteroscopy ; CNTF ; CNTFRα ; LNCaP ; 22Rv1 ; castration resistant ; castration sensitive ; STAT3 ; ERK ; MMP ; biomarker ; Gleason grade ; transforming growth factor-β family ; activin ; INHBA ; INHBB ; INHBC ; prostate-specific antigen ; false-positive results ; real world-data ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
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  • 39
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    Frontiers Media SA
    Publication Date: 2023-12-21
    Description: Epigenetics is the study of changes in gene activity that are heritable but not caused by changes in the DNA sequence. By modulating gene activities, epigenetic changes regulate cell functions. They include DNA methylation, histone posttranslational modifications and gene silencing by the action of non-coding RNAs, particularly microRNAs. It is now clear that epigenetic changes regulate B cell development. By acting in concert with networks of transcription factors, they modulate the activation of B cell lineage specific gene programs and repress inappropriate gene transcription in particular B cell differentiation states. A hallmark of B cell development in the bone marrow is the assembly of the B cell receptor (BCR) for antigen through rearrangement of immunoglobulin heavy (IgH) and light (IgL) chain V(D)J genes, as mediated by RAG1/RAG2 recombinases. Ig V(D)J rearrangement critically times the progression from pro-B cell to pre-B cell and, finally, mature B cell. Such progression is modulated by epigenetic marks, such as DNA methylation and histone posttranslational modifications, that increase chromatin accessibility and target RAG/RAG2 to V, D and J DNA. It is also dependent on the expression of multiple microRNAs. Mice deficient in Ago2, which is essential for microRNA biogenesis and function, have B cell development blocked at the pro-B cell stage. In agreement with this, B cell specific ablation of microRNA by B cell-specific knockout of Dicer virtually blocks B cell differentiation at the pro-B to pre-B cell transition. After mature B cells encounter antigen, changes of the epigenetic landscape are induced by the same stimuli that drive the antibody response; such epigenetic changes underpin the maturation of the antibody response itself. They instruct those B cell differentiation processes, somatic hypermutation (SHM), class switch DNA recombination (CSR) and plasma cell differentiation, that are central to the maturation of the antibody response as well as differentiation of memory B cells. Inducible histone modifications, together with DNA methylation and microRNAs modulate the transcriptome, particularly the expression of activation-induced cytidine deaminase (AID), central to SHM and CSR, and B lymphocyte-induced maturation protein-1 (Blimp-1), which is central to plasma cell differentiation. Combinatorial histone modifications also function as histone codes in the targeting of the CSR and, possibly, the SHM machinery to the Ig locus by recruiting specific adaptors (histone code readers) that can in turn target and/or stabilize CSR/SHM factors. Epigenetic alterations in memory B cells contribute to their functionally distinction from their naive counterparts. Memory B cells inherit epigenetic information from their precursors and acquire new epigenetic marks, which make these resting B cells poised to promptly respond to antigen. The cross/feedback regulation of different epigenetic modifications/elements further increases the complexity of the B cell epigenome, which interacts with the genetic information for precise modulation of gene expression. It is increasingly evident that epigenetic dysregulation in B cells, including aberrant expression of microRNAs, can result in aberrant antibody responses to microbial pathogens, emergence of pathogenic autoantibodies or B cell neoplastic transformation. Epigenetic marks are potential targets for new therapeutics in autoimmunity and B cell malignancy.
    Keywords: R5-920 ; RC581-607 ; BLIMP-1 ; CSR ; immunoglobulin ; memory B cell ; Plasma cell ; V(D)J Recombination ; microRNA ; SHM ; AID ; epigenetics ; bic Book Industry Communication::M Medicine
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  • 40
    Publication Date: 2023-12-21
    Description: Excessive alcohol drinking represents a major social and public health problem for several countries. Alcohol abuse during pregnancy leads to a complex syndrome referred to as fetal alcohol spectrum disorders (FASD), chiefly characterized by mental retardation. The effects of early exposure to ethanol can be reproduced in laboratory animals and this helped to answer several key questions concerning the human pathology. The interest of experimental models of FASD is twofold. First, they increase our knowledge about the dose and modality of alcohol consumption able to induce damaging effects on the developing brain. Second, experimental models of FASD can provide useful hints to elucidate the basic mechanisms leading to the intellectual disability. In fact, experimental exposure to alcohol can be carried out during discrete, often very restricted, time windows. As a consequence, FASD models, though depending on the multifaceted interference of alcohol with several molecular pathways, can provide valuable information about which specific developmental periods and brain areas are critically involved in the genesis of mental retardation. Putting together data obtained through several experimental paradigms of alcohol exposure and those deriving from other genetic and non-genetic models, one can figure out to what extent different types of mental retardation share common pathogenetic mechanisms. The present Research Topic is aimed at establishing the state of the art of the current research on experimental FASD, focusing on differences and homologies with other types of intellectual disability. The ultimate goal is to find out a common roadmap in view of future therapeutical approaches.
    Keywords: R5-920 ; RC435-571 ; RJ1-570 ; glial cells ; development ; Amygdala ; Fetal Alcohol Spectrum Disorders ; Cerebral Cortex ; Intellectual Disability ; epigenetics ; Apoptosis ; bic Book Industry Communication::M Medicine
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  • 41
    Publication Date: 2023-12-21
    Description: The recent wave of clinical studies demonstrating long-term therapeutic efficacy highlights the enormous potential of gene therapy as an approach to the treatment of inherited disorders and cancer. While in recent years lentiviral vectors have dominated the field of ex vivo gene therapy in man, adeno-associated virus (AAV) vectors have become the platform of choice for the in vivo gene delivery, both local and systemic.Despite the achievements in the clinic however, a number of hurdles remain to be overcome in gene therapy, these include availability of scalable vector production systems, potential issues associated with insertional mutagenesis, and concerns related to immunogenicity of gene therapeutics. For AAV vectors, clinical trials showed that immunity directed against the vector could either prevent transduction of a target tissue or limit the duration of therapeutic efficacy. Initial observations in the context of a gene therapy trial for hemophilia spurred over a decade efforts by gene therapists and immunologists to understand the mechanism and identify factors that contribute to AAV’s immunogenicity, including the prevalence of B cell and T cell immunity to wild type AAV in humans and the interaction of AAV vectors with the innate and adaptive immune system. Despite a number of important contributions in particular in the more recent past, our knowledge on the immunology of gene transfer is still rudimental; this is partly due to the fact that the basic understanding of the complex balance between tolerance and immunity to an antigen, key aspect of gene transfer with AAV, keeps evolving rapidly. However, continuing work towards a better definition of the interaction of viral vectors with the immune system has led to significant advances in the knowledge of the factors influencing the outcome of gene transfer, such as the vector dose, the immune privilege of certain tissues, and the induction of tolerance to an antigen. A better understanding of the structure-function relationship of the viral capsid has boosted the development of novel immune-escape vector variants. In addition, novel immunomodulatory strategies were established to prevent or reduce anti-capsid immunity have been developed and are being tested in preclinical models and in clinical trials. Together, these advances are bringing us closer to the goal of achieving safe and sustained therapeutic gene transfer in humans. In this research topic, a collection of Original Research and Review Articles highlights critical aspects of the interaction between gene AAV vectors and the immune system, discussing how these interactions can be either detrimental or constitute an advantage, depending on the context of gene transfer, and providing tools and resources to better understand the issue of immunogenicity of AAV vectors in gene transfer.
    Keywords: R5-920 ; RC581-607 ; antibody response ; Clinical Trial ; Gene Therapy ; Regulatory T Cell ; Immunomodulation ; Tolerance induction ; adaptive and innate immunity ; adeno-associated virus ; Vaccine ; Epitopes ; bic Book Industry Communication::M Medicine
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  • 42
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Unconventional reservoirs are usually complex and highly heterogeneous, such as shale, coal, and tight sandstone reservoirs. The strong physical and chemical interactions between fluids and pore surfaces lead to the inapplicability of conventional approaches for characterizing fluid flow in these low-porosity and ultralow-permeability reservoir systems. Therefore, new theories and techniques are urgently needed to characterize petrophysical properties, fluid transport, and their relationships at multiple scales for improving production efficiency from unconventional reservoirs. This book presents fundamental innovations gathered from 21 recent works on novel applications of new techniques and theories in unconventional reservoirs, covering the fields of petrophysical characterization, hydraulic fracturing, fluid transport physics, enhanced oil recovery, and geothermal energy. Clearly, the research covered in this book is helpful to understand and master the latest techniques and theories for unconventional reservoirs, which have important practical significance for the economic and effective development of unconventional oil and gas resources.
    Keywords: TA1-2040 ; T1-995 ; shale gas ; permeability ; prediction by NMR logs ; matrix–fracture interaction ; faults ; remaining oil distributions ; unconventional reservoirs ; coal deformation ; reservoir depletion ; carbonate reservoir ; nanopore ; fracturing fluid ; pseudo-potential model ; shale reservoirs ; matrix-fracture interactions ; multi-scale fracture ; succession pseudo-steady state (SPSS) method ; fluid transport physics ; integrated methods ; chelating agent ; dissolved gas ; non-equilibrium permeability ; effective stress ; fractal ; fracture network ; spontaneous imbibition ; tight oil ; porous media ; 0-1 programming ; the average flow velocity ; geothermal water ; micro-fracture ; pore types ; pore network model ; petrophysical characterization ; nitrogen adsorption ; analysis of influencing factors ; mudstone ; rheology ; velocity profile ; shale permeability ; flow resistance ; global effect ; tight sandstones ; fractal dimension ; contact angle ; temperature-resistance ; fractured well transient productivity ; reservoir classifications ; deep circulation groundwater ; viscosity ; NMR ; fractional diffusion ; lattice Boltzmann method ; multiporosity and multiscale ; fractal geometry ; imbibition front ; productivity contribution degree of multimedium ; wetting angle ; pH of formation water ; enhanced oil recovery ; isotopes ; tight sandstone ; fracture diversion ; shale ; SRV-fractured horizontal well ; low-salinity water flooding ; shale gas reservoir ; tight reservoirs ; fracture continuum method ; tight oil reservoir ; Lucaogou Formation ; hydraulic fracturing ; clean fracturing fluid ; recovery factor ; flow regimes ; local effect ; complex fracture network ; pore structure ; gas adsorption capacity ; polymer ; non-linear flow ; conformable derivative ; production simulation ; analytical model ; enhanced geothermal system ; multi-scale flow ; experimental evaluation ; extended finite element method ; fluid-solid interaction ; groundwater flow ; well-placement optimization ; thickener ; imbibition recovery ; equilibrium permeability ; slip length ; large density ratio ; clay mineral composition ; finite volume method ; volume fracturing ; influential factors ; sulfonate gemini surfactant ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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  • 43
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Recently, new wide-band energy gap semiconductors can be grown by ALD, PLD, sputtering, or MOCVD. They have great potential for the fabrication and application to TFTs. Inorganic semiconductors have good stability against environmental degradation over their organic counterparts, whereas organic materials are usually flexible, transparent, and when solution-processed at low temperatures, are prone to degradation when exposed to heat, moisture, and oxygen. For this Special Issue, we invited researchers to submit papers discussing the development of new functional and smart materials, and inorganic as well as organic semiconductor materials, such as ZnO, InZnO, GaO, AlGaO, AnGaO, AlN/GaN, conducting polymers, molecular semiconductors, perovskite-based materials, carbon nanotubes, carbon nanotubes/polymer composites, and 2D materials (e.g., graphene, MoS2) and their potential applications in display drivers, radio frequency identification tags, e-paper, gas, chemical and biosensors, to name but a few.
    Keywords: TA1-2040 ; TK1-9971 ; T1-995 ; charge transport and injection mechanisms ; optical synaptic devices ; flat panel displays ; simulation ; persistent photoconductivity ; hydrogen ; interdigitated ; interface state trap density ; technology computer aided design (TCAD) ; oxygen defects ; Corbino ; transistor model evaluation ; metal-halide lamp ; InGaZnOx ; contact resistances ; chemical treatment ; colour difference ; organic transistor ; equivalent circuit ; channel-length dependence ; just noticeable difference ; oxide semiconductor ; OTFT ; chromaticity ; modeling contact effects ; oxygen deficiency ; dual-threshold inverter ; surface treated ; charge-carrier-mobility extraction ; optical detecting ; thin film transistor ; green ; photo-sensors ; modelling ; capacitor ; TFT-LCD ; organic thin-film transistor ; spectrum ; hydrogen effect ; organic film growth ; transparent conducting oxides ; quartz-halogen lamp ; optical ; blue LED ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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  • 44
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-07-14
    Description: Global cancer incidence and death are expected to increase in the next decades. Inappropriate therapeutic regimens and tumor recurrence due to the development of drug resistance are two major clinical challenges impacting poor patient outcomes, which is critical to the discovery and development of new anticancer drugs. Over the last few decades, the marine environment has proved to be a key source of molecules with potent anticancer properties. The Special Issue, “Marine Natural Products as Anticancer Agents 2.0”, gathered eleven publications, including two reviews and nine research articles, about the anticancer activities of marine natural and/or derived products on in vitro 2D and 3D cellular models, and/or in vivo models of colorectal, breast, lung, myeloma, liver, leukemia, and melanoma cancers. Altogether, the eleven scientific papers published in this Special Issue provide an exciting overview of marine natural products as potential anticancer agents.
    Keywords: Clavatadine C ; spirocyclic bromotyrosines ; cytotoxicity ; cancer selectivity ; marine compounds ; melanoma A-375 cell line ; Sarcophyton convolutum ; sarcoconvolutum A–E ; cembrenoids ; anti-angiogenesis ; bromophenols ; tube formation ; vasculogenic mimicry ; brefeldin A ; ester derivative ; chronic myelogenous leukemia ; BCR-ABL ; proliferation inhibition ; molecular modeling ; 5-O-(N-Boc-l-alanine)-renieramycin T ; Xestospongia sp. ; marine sponge ; lung cancer ; anti-cancer ; cancer stem cells ; apoptosis ; Akt ; c-Myc ; migrastatics ; cell migration ; cell invasion ; metastasis ; terpenes ; algae ; marine natural products ; mitochondrial dysfunction ; oxidative stress ; anticancer ; Sphaerococcus coronopifolius ; seaweed ; Laminaria japonica ; Laminaria japonica peptides ; cancer ; liver ; cell cycle ; porphyrin ; Isabela ; hemin ; X-ray diffraction ; NOESY NMR ; cytotoxic ; colorectal cancer ; 5-fluorouracil ; 7S,15R-dihydroxy-16S,17S-epoxy-docosapentaenoic acid ; tumor-associated macrophages ; chemoresistance ; fucoidan ; immunopotentiation ; immunomodulatory ; immunotherapy ; cancer treatment ; cytokines ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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  • 45
    Publication Date: 2023-12-21
    Description: CD4+ T lymphocytes play an essential role in host defense against bacterial, parasitic and viral infections. During infection, under the influence of intrinsic signals received through peptide-MHC/TCR interactions and extrinsic signals provided by pathogen-conditioned dendritic and other accessory cells, CD4+ T cells proliferate and differentiate into specialized T helper (Th) effectors, which produce distinct sets of cytokines tailored to combat a specific class of microbes. The concept of CD4+ T cell multi-functionality was developed after the seminal discovery of Th1 and Th2 cells nearly 30 years ago. Although the Th1/Th2 paradigm has successfully withstood the test of time, in the past decade additional Th subsets (Th17, Tfh, Th22, Th9) have been identified. Similarly, single cell analyses of cytokines and master transcriptional factors have revealed that, at the population level, CD4+ T cell responses are far more heterogeneous than initially anticipated. While some of the checkpoints in Th cell specification have been identified, recent studies of transcriptional and epigenetic regulation have uncovered a significant flexibility during the course CD4+ T lymphocyte polarization. In addition, Th cells expressing cytokines with counteracting functions, as a measure of self-regulation, display yet another level of diversity. Understanding the mechanisms that control the balance between stability vs. plasticity of Th effectors both at the time of initiation of immune response and during development of CD4 T cell memory is critical for the rational design of better vaccines and new immunotherapeutic strategies. This research topic will cover current views on Th cell development, with a focus on the mechanisms that govern differentiation, function and regulation of effector Th cells in the context of microbial infections.
    Keywords: R5-920 ; RC581-607 ; Infection ; Dendritic Cells ; Cytokines ; Immunoregulation ; CD4 lymphocytes ; Memory ; long noncoding RNA ; Macrophages ; Metabolism ; Th1 Th2 ; bic Book Industry Communication::M Medicine
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  • 46
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: This Special Issue covers a wide range of areas—including building orientation, service life, use of photocatalytically active structures and PV facades, implications of transportation system, building types (i.e., high rise, multilevel, commercial, residential), life cycle assessment, and structural engineering—that need to be considered in the environmental impact assessment of buildings, and the chapters include case studies across the globe. Consideration of these strategies would help reduce energy and material consumption, environmental emissions, and waste generation associated with all phases of a building’s life cycle. Chapter 1 demonstrates that green star concrete exhibits the same structural properties as conventional concrete in Australia. Chapter 2 showed that the use of TiO2 as a photocatalyst on the surface of construction materials with a suitable stable binding agent, such as aggregates, would enable building walls to absorb NOx from air. This study found that TiO2 has the potential to reduce ambient concentrations of NOx from areas where this pollutant becomes concentrated under solar irradiation. Chapter 3 presents the life cycle assessment of architecturally integrated glass–glass photovoltaics in building facades to find the appropriate material composition for a multicolored PV façade offering improved environmental performance. Chapter 4 shows that urban office buildings lacking appropriate orientation experienced indoor overheating. Chapter 5 details four modeling approaches that were implemented to estimate buildings’ response towards load shedding. Chapter 6 covers the life cycle GHG emissions of high-rise residential housing block to discover opportunities for environmental improvement. Chapter 7 discusses an LCA framework that took into account variation in the service life of buildings associated with the use of different types of materials. Chapter 8 presents a useful data mining algorithm to conduct life cycle asset management in residential developments built on transport systems.
    Keywords: TA1-2040 ; T1-995 ; wash water ; greenhouse gases ; environmental life cycle assessment ; sustainable-development ; transit-policy ; public-engagement ; Multilevel buildings ; building integrated photovoltaic ; slag ; operational energy ; life-cycle social analysis ; building ; travel-satisfaction ; TEASER ; BIPV ; photocatalytic construction materials ; functionalized aggregate ; green star concrete ; work-commute ; shallow plan forms ; life cycle assessment ; recycled aggregate ; environmental remediation ; block of buildings ; rain cladding ; LCA ; sustainability ; peak shaving ; residential building ; indoor overheating ; LCI ; air pollution ; environmental performance ; service life ; nitric oxides ; thermal model ; coloured glass ; demand response ; modal-variability ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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  • 47
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-02-01
    Description: Extracellular vesicles (EVs) are particles wrapped in a lipid bilayer membrane and are naturally released from cells. This kind of cargo vessel is a nanostructure that mainly transfers lipids, proteins, various nucleic acid fragments, and metabolic components to neighboring cells or distant parts of the body through the circulatory system. EVs are of great significance to the communication mechanism between cells. This book collects feature articles to enhance our understanding of the biological characteristics of EVs and their potential applications.
    Keywords: extracellular vesicle ; precision oncology ; cancer biomarker ; prostate cancer ; drug delivery ; extracellular vesicles ; lysosome ; nanocarriers ; ultrasound ; size exclusion chromatography ; differential ultracentrifugation ; head and neck squamous cell carcinoma (HNSCC) ; exosomes ; cancer ; biomarker ; diagnostic ; therapy ; liquid biopsy ; small extracellular vesicles (sEV) ; tumor-derived exosomes (TEX) ; melanoma cell-derived exosomes (MTEX) ; proteomics ; tumor microenvironment ; biomarkers ; ectosomes ; neoplasia ; microvesicles ; small extracellular vesicles ; isolation ; purification ; size-exclusion chromatography ; ultracentrifugation ; sucrose density cushion ; lymph node ; spleen ; solid tissue ; microvesicle ; exosome ; cancer therapeutic ; drug carrier ; flow cytometry ; immunophenotyping ; swarm detection ; tumor-associated macrophages ; macrophage polarization ; mannose receptor ; HIV-1 Nef ; glioblastoma ; microRNA ; immunoprecipitation ; CD44 ; human milk ; nutrient ; microbiota ; microRNAs ; nanocommunicator ; diagnostic biomarker ; drug delivery vehicle ; personalized cancer immunotherapy ; therapeutic agents ; cell-to-cell communication ; ionising radiation ; non-targeted effects ; signalling ; imaging flow cytometry ; biomarker reservoirs ; cancer diagnostics ; disease monitoring ; large EVs ; ovarian cancer cells ; ES-2 ; OAW-42 ; adipose tissue origin mesenchymal stem cells ; n/a ; bic Book Industry Communication::M Medicine
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  • 48
    Publication Date: 2023-12-21
    Description: Lipids are best known as energy storing molecules and core-components of cellular membranes, but can also act as mediators of cellular signaling. This is most prominently illustrated by the paramount importance of the phospholipase C (PLC) and phosphoinositide 3-kinase (PI3K) signaling pathways in many cells, including T cells and cancer cells. Both of these enzymes use the lipid phosphatidylinositol(4,5)bisphosphate (PIP2) as their substrate. PLCs produce the lipid product diacylglycerol (DAG) and soluble inositol(1,4,5)trisphosphate (IP3). DAG acts as a membrane tether for protein kinase C and RasGRP proteins. IP3 is released into the cytosol and controls calcium release from internal stores. The PI3K lipid product phosphatidylinositol(3,4,5)trisphosphate (PIP3) controls signaling by binding and recruiting effector proteins such as Akt and Itk to cellular membranes. Recent research has unveiled important signaling roles for many additional phosphoinositides and other lipids. The articles in this volume highlight how multiple different lipids govern T cell development and function through diverse mechanisms and effectors. In T cells, lipids can orchestrate signaling by organizing membrane topology in rafts or microdomains, direct protein function through covalent lipid-modification or non-covalent lipid binding, act as intracellular or extracellular messenger molecules, or govern T cell function at the level of metabolic regulation. The cellular activity of certain lipid messengers is moreover controlled by soluble counterparts, exemplified by symmetric PIP3/inositol(1,3,4,5)tetrakisphosphate (IP4) signaling in developing T cells. Not surprisingly, lipid producing and metabolizing enzymes have gained attention as potential therapeutic targets for immune disorders, leukemias and lymphomas.
    Keywords: R5-920 ; RC581-607 ; eicosanoid ; Inositol ; diacylglyerol ; PI3K ; Vitamin D ; T cell ; SHIP ; Pten ; Adipokine ; Lipid ; bic Book Industry Communication::M Medicine
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  • 49
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-10-25
    Description: This reprint is related to the latest research in the field of thyroid surgery, including molecular and imaging diagnosis, surgical treatment, and the treatment of recurrent disease and advanced thyroid carcinoma.
    Keywords: thyroid carcinoma ; prophylactic central lymph node dissection ; lymph node metastases ; RET ; medullary thyroid carcinoma ; clinical management ; variants of uncertain significance ; differentiated thyroid cancer ; papillary thyroid cancer ; minimal extrathyroidal extension ; radioactive iodine therapy ; prognosis ; TNM ; histology ; multifocality ; lymph node metastasis ; vascular invasion ; autoimmune thyroid diseases ; radioiodine refractory ; Lenvatinib ; 18F-FDG-PET/CT ; cost-benefit analysis ; economics ; medical ; thyroid neoplasms ; radiomics ; ultrasound ; magnetic resonance imaging ; computer tomography ; prediction ; classification ; angiogenic microenvironment ; prognostic factors ; antiangiogenic therapy ; therapeutic target ; tumor microenvironment ; tumor behavior ; proliferation pathways ; cell cycle control pathways ; angiogenesis process ; thyroid cancer ; Gal-3 expression ; NIFTP ; EFVPTC ; lymphocytic thyroiditis (LT) ; immunohistochemical (IHC) analysis ; molecular imaging ; theranostics ; companion diagnostics ; immunoPET ; anaplastic thyroid cancer ; poorly thyroid cancer ; genetic landscape ; genetically guided therapy ; fluorodeoxyglucose F18 (18F-FDG) ; positron emission tomography (PET) ; magnetic resonance imaging (MRI) ; recurrence ; neoplasm metastasis ; thyroid surgery ; hypoparathyroidism ; fluorescence-guided surgery ; near-infrared autofluorescence ; PRKAR1A ; PKA ; Carney complex ; cAMP ; bone metastasis ; metastasectomy ; stereotactic radiosurgery ; ultrasound imaging ; thyroid nodule ; fine-needle aspiration ; papillary thyroid carcinoma ; lobectomy ; operative extent ; CONUT score ; tyrosine kinase inhibitors ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
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  • 50
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: By the late 1940s, and since then, the continuous development of dislocation theories have provided the basis for correlating the macroscopic time-dependent deformation of metals and alloys—known as creep—to the time-dependent processes taking place within the metals and alloys. High-temperature deformation and stress relaxation effects have also been explained and modeled on similar bases. The knowledge of high-temperature deformation as well as its modeling in conventional or unconventional situations is becoming clearer year by year, with new contemporary and better performing high-temperature materials being constantly produced and investigated.This book includes recent contributions covering relevant topics and materials in the field in an innovative way. In the first section, contributions are related to the general description of creep deformation, damage, and ductility, while in the second section, innovative testing techniques of creep deformation are presented. The third section deals with creep in the presence of complex loading/temperature changes and environmental effects, while the last section focuses on material microstructure–creep correlations for specific material classes. The quality and potential of specific materials and microstructures, testing conditions, and modeling as addressed by specific contributions will surely inspire scientists and technicians in their own innovative approaches and studies on creep and high-temperature deformation.
    Keywords: TA1-2040 ; T1-995 ; TN1-997 ; Larson–Miller parameter ; n/a ; visualization ; bond coat ; hydrogen ; poly-crystal ; Gibbs free energy principle ; constitutive equations ; creep damage ; DFT ; finite element method ; austenitic stainless steel ; strain rate sensitivity ; MCrAlY ; excess volume ; superalloy ; scanning electron microscopy ; creep buckling ; dislocation dynamics ; creep ; elevated temperature ; modelling ; size effect ; residual stress ; superalloy VAT 32 ; water vapor ; activation energy ; small angle neutron scattering ; superalloy VAT 36 ; metallic glass ; iron aluminides ; Gr.91 ; internal stress ; relaxation fatigue ; multiaxiality ; creep grain boundary ; grain boundary cavitation ; cavitation ; solute atom ; stress exponent ; external pressure ; P92 ; TMA ; low cycle fatigue ; nanoindentation ; high temperature ; FEM ; intrinsic ductility ; normalizing ; creep ductility ; creep rupture mechanism ; microstructural features ; simulate HAZ ; P92 steel ; glide ; ferritic–martensitic steel ; creep rupture ; cyclic softening ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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  • 51
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a severe chronic health condition that is often misunderstood or ignored by health establishments. The lack of definitive diagnostic markers to separate ME/CFS patients from the healthy population as well as from other chronic disorders is problematic for both health professionals and researchers. A consortium of Australian researchers gathered to systematically understand ME/CFS, ranging from a deep analysis of clinical and pathology data to metabolomic profiles and the investigation of mitochondrial function. From this broad collaboration, a number of compelling insights have arisen that may form the basis of specific serum, blood, and/or urinary biomarkers of ME/CFS. This Special Edition reports on a conference centred on these biomedical discoveries, with other contributions, with a translation focus for predictive markers for ME/CFS diagnosis. By supporting health professionals with developments in diagnostics for this condition, the patients and their families will hopefully benefit from an improved recognition of the biomedical underpinnings of the condition and will be better able to access the care that is urgently required. This Special Edition contains a mix of speaker submissions and other accepted manuscripts that contributed to our objective of advancing biomedical insights to enable the accurate diagnosis of ME/CFS.
    Keywords: R5-920 ; RM1-950 ; fatigue syndrome ; n/a ; work rehabilitation ; tryptophan metabolism ; substrate inhibition ; myalgic encephalomyelitis ; 3-dioxygenase ; ME (Myalgic Encephalomyelitis) ; assessment ; myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) ; muscles ; hypoacetylation ; circadian rhythm ; immune system ; chronic ; CFS (Chronic Fatigue Syndrome) ; energy metabolism ; ME/CFS ; immunological ; cytokine ; bistability ; diagnosis ; biomarker ; symptoms ; kynurenine pathway ; inflammation and immunity ; metabolism ; neuro-inflammation ; pathology ; signaling ; exercise ; Epstein Barr virus ; methylhistidine ; hypothalamic–pituitary–adrenal axis ; potential biomarkers ; critical point ; inflammation ; histone deacetylation ; participatory research ; neurology ; neuroimmune ; activin ; mitochondria ; patient-driven questionnaire ; medical retirement ; machine learning ; prognosis ; gut microbiota ; post-exertional malaise ; chronic fatigue syndrome ; mathematical model ; reference intervals ; diagnostic biomarker ; indoleamine-2 ; bic Book Industry Communication::M Medicine
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  • 52
    Publication Date: 2023-12-21
    Description: Experiences during early life program the central nervous- and endocrine-systems with consequences for susceptibility to physical and mental disorders. These programming effects depend on genetic and epigenetic factors, and their outcome leads to an adaptive or maladaptive phenotype to a given later environmental context. This Research Topic focused on the hypothalamus-pituitary-adrenal (HPA)-axis and stress-related phenotypes, and on how HPA-axis programming by the environment precisely occurs. We included original research, mini-review and review papers on a broad range of topics related to HPA-axis programming.
    Keywords: R5-920 ; RC648-665 ; RC321-571 ; Q1-390 ; HPA axis ; Vulnerability ; resilience ; early life stress ; materna ; bic Book Industry Communication::M Medicine
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  • 53
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: With increasing power levels and power densities in electronics systems, thermal issues are becoming more and more critical. The elevated temperatures result in changing electrical system parameters, changing the operation of devices, and sometimes even the destruction of devices. To prevent this, the thermal behavior has to be considered in the design phase. This can be done with thermal end electro-thermal design and simulation tools. This Special Issue of Energies, edited by two well-known experts of the field, Prof. Marta Rencz, Budapest University of Technology and Economics, and by Prof. Lorenzo Codecasa, Politecnico di Milano, collects twelve papers carefully selected for the representation of the latest results in thermal and electro-thermal system simulation. These contributions present a good survey of the latest results in one of the most topical areas in the field of electronics: The thermal and electro-thermal simulation of electronic components and systems. Several papers of this issue are extended versions of papers presented at the THERMINIC 2018 Workshop, held in Stockholm in the fall of 2018. The papers presented here deal with modeling and simulation of state-of-the-art applications that are highly critical from the thermal point of view, and around which there is great research activity in both industry and academia. Contributions covered the thermal simulation of electronic packages, electro-thermal advanced modeling in power electronics, multi-physics modeling and simulation of LEDs, and the characterization of interface materials, among other subjects.
    Keywords: TA1-2040 ; T1-995 ; thermal interface material ; thermal aging ; modeling ; LED compact thermal models ; niobium pentoxide ; model-order reduction ; ferromagnetic cores ; LED digital twin ; Cauer RC ladder ; in-situ characterization ; electronic packages ; time domain thermoreflectance ; multi-domain compact model ; power LEDs ; DC–DC converters ; structure function ; boundary condition independent ; electric aircraft ; multi-LED ; modelling ; light emitting diodes ; thin film ; JEDEC metrics ; tool agnostic ; power losses ; switching ; dynamic thermal compact model ; thermal transient testing ; reliability ; thermal transient analysis ; thermal simulation ; non-destructive testing ; IGBT ; carbon nanotubes ; compact thermal model ; power semiconductor devices ; SPICE ; phosphor light conversion ; thermal management ; LED luminaire design ; design flow ; thermal characterization ; motor cooling ; thermal phenomena ; silicone dome ; LED ; secondary heat path ; multi-domain modelling ; heating and optical power ; transient analysis ; thermal testability ; thermal conductivity ; multiple heat source ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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  • 54
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-05-11
    Description: This reprint emphasizes the perspectives and challenges surrounding COVID-19 and obesity-related cancers, including but not limited to the risk factors of severe COVID-19 in cancer patients; the complications of COVID-19 in cancer patients; the challenges in cancer treatment and surgery; guidelines for cancer care during COVID-19; delayed diagnosis and suboptimal cancer management; the impact of COVID-19 on cancer screening, early diagnosis and cancer presentation; immune response after SARS-CoV-2 infection and vaccination in cancer patients; psychological distress among cancer survivors; telehealth in cancer care; the role of diet and nutraceuticals in the prevention of severe COVID-19 and cancer; and the effects of COVID-19 pandemic on cancer research.
    Keywords: COVID-19 ; neutropenia ; G-CSF treatment ; respiratory failure ; colorectal neoplasms ; gastrointestinal neoplasms ; immune checkpoint inhibitors ; neoplasms ; oncogenic viruses ; oncolytic virotherapy ; post-acute COVID-19 syndrome ; reactive oxygen species ; tumor escape ; SARS-CoV-2 ; thyroid cancer ; differentiated thyroid cancer ; COVID-19 severity ; inflammation ; immunity ; oxidative stress ; obesity ; SARS-Cov-2 ; oncology ; cancer screening ; clinical trials ; melanoma ; management ; pandemic ; teledermatology ; diagnostic delay ; immunotherapy ; vaccination ; lymph adenopathy ; cancer ; nutraceuticals ; supplements ; colorectal ; meta-analysis ; gynecologic oncology ; malignancy ; blood cancer ; hematologic malignancy ; leukemia ; lymphoma ; multiple myeloma ; myelodysplasia ; breast cancer ; cancer care ; screening ; surgery ; psychological distress ; cancer therapies ; immunogenicity ; safety ; vaccine hesitancy ; tumor subtype ; mortality ; intensive care unit ; medico-administrative data ; France ; n/a ; bic Book Industry Communication::M Medicine
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  • 55
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: This book presents an interesting sample of the latest advances in optimization techniques applied to electrical power engineering. It covers a variety of topics from various fields, ranging from classical optimization such as Linear and Nonlinear Programming and Integer and Mixed-Integer Programming to the most modern methods based on bio-inspired metaheuristics. The featured papers invite readers to delve further into emerging optimization techniques and their real application to case studies such as conventional and renewable energy generation, distributed generation, transport and distribution of electrical energy, electrical machines and power electronics, network optimization, intelligent systems, advances in electric mobility, etc.
    Keywords: TA1-2040 ; T1-995 ; n/a ; Stackelberg game ; MILP ; optimal congestion threshold ; magnetic field mitigation ; simulation ; multi-objective particle swarm optimization ; virtual power plant ; internal defect ; day-ahead load forecasting ; neural network ; modular predictor ; multi-objective particle swarm optimization algorithm ; stochastic optimization ; dragonfly algorithm ; unit commitment ; metaheuristic ; multi-population method (MP) ; optimization ; tabu search ; considerable decomposition ; loss minimization ; active distribution system ; islanded microgrid ; dynamic solving framework ; feature selection ; electric energy costs ; power factor compensation ; dependability ; interactive load ; overhead ; energy internet ; evolutionary computation ; wind power ; developed grew wolf optimizer ; underground ; ETAP ; fuzzy algorithm ; electric vehicles ; Schwarz’s equation ; evolutionary algorithms ; electric power contracts ; congestion management ; optimizing-scenarios method ; building energy management system ; particle encoding method ; ringdown detection ; HOMER software ; DC optimal power flow ; prosumer ; constrained parameter estimation ; distributed generations (DGs) ; strong track filter (STF) ; transient stability ; calibration ; cost minimization ; radiance ; decentralized and collaborative optimization ; hybrid renewable energy system ; renewable energy sources ; rural electrification ; distribution network reconfiguration ; interval variables ; optimization methods ; particle swarm optimization ; hierarchical scheduling ; micro grid ; AC/DC hybrid active distribution ; consensus ; artificial bee colony ; CCHP system ; data center ; support vector machine ; affinity propagation clustering ; extended Kalman filter ; affine arithmetic ; linear discriminant analysis (LDA) ; current margins ; heterogeneous networks ; Cameroon ; hybrid method ; distributed heat-electricity energy management ; discrete wind driven optimization ; fitness function ; cross-entropy ; GenOpt ; wind energy ; demand uncertainty ; UC ; off-design performance ; genetic algorithm ; energy storage ; the biomimetic membrane computing ; power system optimization ; electric vehicle ; power architectures ; economic load dispatch problem (ELD) ; runner-root algorithm (RRA) ; Cable joint ; battery energy storage system ; load curtailment ; integration assessment ; power system unit commitment ; artificial lighting ; power flow ; hybrid membrane computing ; two-point estimation method ; low-voltage networks ; demand bidding ; non-sinusoidal circuits ; energy flow model ; power transfer distribution factors ; sustainability ; HVAC system ; voltage deviation ; street light points ; radial basis function ; energy storage system ; charging/discharging ; power systems ; intelligent scatter search ; MV/LV substation ; optimal power flow ; stochastic state estimation ; eight searching sub-regions ; chaos optimization algorithm (COA) ; mutual information theory ; inter-turn shorted-circuit fault (ISCF) ; C&I particle swarm optimization ; multiobjective optimization ; passive shielding ; sub-Saharan Africa ; micro-phasor measurement unit ; geometric algebra ; bio-inspired algorithms ; adaptive consensus algorithm ; energy management ; PCS efficiency ; multi-stakeholders ; generalized generation distribution factors ; the genetic algorithm based P system ; JAYA algorithm ; thermal probability density ; power optimization ; pumped-hydro energy storage ; smart grid ; two-stage feature selection ; piecewise linear techniques ; photovoltaic ; SOCP relaxations ; switched reluctance machine (SRM) ; optimal reactive power dispatch ; optimal operation ; controllable response ; off-grid ; active shielding ; transformer-fault diagnosis ; IEEE Std. 80-2000 ; principal component analysis ; demand response ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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  • 56
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-01-31
    Description: Structural mechanics is an important field of engineering. The main goal of structural mechanics is to ensure that structures are safe and durable so that catastrophic situations can be prevented, which can otherwise cause loss of life, environmental pollution and financial losses. Depending on the uses of the structure and the conditions that the structure is subjected to, special treatment may be required for the analysis. Specifically, marine structures are subjected to harsh environmental conditions due to the marine environment, which can cause several different damage mechanisms including fatigue and corrosion. This book on “Marine structures” considers a wide range of areas related to marine structures and provides a compilation of numerical and experimental studies related to “Marine structures” research.
    Keywords: TC1501-1800 ; TA1-2040 ; T1-995 ; shock loads ; n/a ; jacket structures ; protective device ; tripod support structures ; soil-pile-structure interaction ; acoustic metamaterials ; semi-active ; jacket platform ; solitons ; waves ; biofouling ; seawater piping systems ; motion response ; earthquake ; low-frequency sound ; failure mechanism ; free-surface flow ; depressed bottom ; performance prediction ; acoustic band gap ; marine growth ; uncoupled analysis ; towing resistance ; viscous fluid flow ; ice-induced vibration ; superelement ; anti-collision assessment ; peridynamics ; steel ; integrated numerical model ; fairlead position ; reliability ; cross-flow ; coupled analysis ; morphology evolution ; composites ; tuned mass damper ; towing method ; wave loading ; vortex-induced vibration ; coastal protection structures ; structural control ; vortical flow ; critical mass ratio ; flexible pipe ; stochastic modeling ; offshore wind turbine ; hydrodynamics ; high pressure ; offshore integrated meteorological mast (OIMM) ; ice-resistant cone ; sediment transport ; offshore wind ; thermomechanical ; corrosion detection
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  • 57
    Publication Date: 2023-12-21
    Description: Schistosomiasis is a severe parasitic disease, endemic in 74 developing countries with up to 600 million people, including many children, infected and 800 million at risk of contracting the disease following infection with Schistosoma mansoni, S. haematobium or S. japonicum. Disease burden is estimated to exceed 70 million disability-adjusted life-years, and leads to remarkably high YLD (years lived with disability) rates. Even more importantly, people with schistosomiasis are highly susceptible to malaria, tuberculosis and hepatic and acquired immunodeficiency viruses. There is only one drug, praziquantel, currently available for treatment and it has high efficacy, low cost, and limited side effects. However, only 13% of the target population has received the drug, and those treated are at continuous risk of reinfection necessitating repeated drug administration and the emergence of drug resistant parasites is a constant threat. There currently is no vaccine. While the target of 〉40% protection has been achieved with some molecules such as excretory-secretory proteins including calpain, glyceraldehyde 3-phosphate dehydrogenase, and cysteine peptidases, very recent articles reiterate the findings published during the last 2 decades of the last century, contradicting the established data of the pioneers of schistosome biology. A consensus should be reached without delay, in order to propose collaborative independent experiments and proceed ahead to pre- and clinical trials with efficacious candidate vaccine molecules. The proposed plan aims to finally reach an objective and fruitful agreement , via inviting established and young researchers from the United States, Brazil, China, Australia, and Europe who are working with different vaccine antigens, adjuvants, and approaches for immunization against S. mansoni, S. haematobium, and S. japonicum. It is hoped that the forum will end with a very few candidate antigens and a consensus approach regarding target immune responses, thus leading to encouraging the World Health Organization and other international foundations to sponsor the development and implementation of the urgently required, yet still elusive, vaccine for preventing and eliminating the transmission of schistosomiasis.
    Keywords: R5-920 ; RC581-607 ; Schistosomiasis ; Schistosoma mansoni ; Schistosoma haematobium ; Type 2 cytokines ; Vaccine ; Immune responses ; Schistosoma japonicum ; Vaccine candidates ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-20
    Description: This Book, entiled “Allergic Rhinosinusitis and Airway Diseases”, presents the concept of united airway disease interaction, which comprises chronic rhinosinusitis and other lower airway disorders such as asthma. This concept furthers a deeper comprehension on the pathophysiology and management of upper and lower airway diseases. In this Book, the published papers cover different interesting topics such as healthcare equality, advanced biomarkers, accurate diagnosis and treatment, occupational exposure-induced upper airway allergy and neoplastic disease mimicking chronic rhinosinusitis.
    Keywords: chronic rhinosinusitis ; B-cell lymphoproliferative disorder ; sinus ; nasal allergies ; tannery worker ; Kanpur ; asthma ; ovalbumin ; saffron ; salbutamol ; IL’s ; TNF-α ; allergic rhinitis ; bronchial asthma ; allergy ; Th17 cells ; IL-17 ; IL-33 ; microRNA ; miR ; airway mucosal inflammation ; united airway disease ; acute rhinosinusitis ; acute recurrent rhinosinusitis ; Mediterranean diet ; nutritional evaluation ; nutritional therapy ; olfactory dysfunction ; anosmia ; post-acute COVID-19 ; nitric oxide ; NO ; exhaled NO ; FENO ; nasal peak flow ; atopic status ; total IgE ; specific IgE ; childhood asthma ; immunoblot ; ImmunoCAP ; otolaryngology ; sinusitis ; ethnic groups ; patient-reported outcome measures ; quality of life ; social justice ; n/a ; bic Book Industry Communication::M Medicine
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  • 59
    Publication Date: 2023-12-21
    Description: In the perioperative setting and in intensive care medicine, early and effective hemodynamic management including fluid therapy and administration of vasoactive drugs to maintain vital organ perfusion and oxygen delivery is mandatory. Understanding the different approaches in the management of critically ill patients during the resuscitation and further management is essential to initiate adequate context- and time-specific interventions. Optimization of hemodynamic variables to achieve a balance between organ oxygen delivery and consumption is a cornerstone. In general, cardiac output (i.e., the blood flow) is considered a major determinant of oxygen supply and thus its monitoring is regarded helpful. However, indicators of oxygen requirements are equally necessary to assess adequacy of oxygen supply. Currently, more and more less or even totally non-invasive monitoring systems have been developed and clinically introduced, but they require validation in particular clinical settings. Cardiac output monitors and surrogates of organ oxygenation only enable to adequately guide management, as patient’s outcome is determined by acquisition and interpretation of accurate measurements, and finally, suitable management decisions. This Research Topic focuses on the currently available techniques, especially the less and non-invasive ones, in the field of hemodynamic monitoring in the perioperative setting and in critically ill patients while summarizing their advantages and limitations.
    Keywords: R5-920 ; Blood Pressure ; Cardiovascular dynamics ; goal-directed therapy ; intensive care medicine ; Cardiac Output ; Anesthesiology ; bic Book Industry Communication::M Medicine
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  • 60
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: This Special Issue on Antimicrobial Resistance in Environmental Waters features 11 articles on the monitoring and surveillance of antimicrobial resistance (AMR) in natural aquatic systems (i.e., reservoirs, rivers), and effluent discharge from water treatment plants to assess the effectiveness of AMR removal and resulting loads in treated waters. Some of the key elements of AMR studies presented in this Special Issue highlight the underlying drivers of AMR contamination in the environment and the evaluation of the hazard imposed on aquatic organisms in receiving environments through ecological risk assessments. As described in this Issue, screening antimicrobial peptide (AMP) libraries for biofilm disruption and antimicrobial candidates are promising avenues for the development of new treatment options to eradicate resistance.
    Keywords: TA1-2040 ; T1-995 ; TA170-171 ; risk assessment ; reuse water ; Acinetobacter junii ; Escherichia coli ; co-occurrence pattern ; EPS ; wastewater treatment plant ; UV-disinfection ; biofilm ; estuary reservoir ; Environmental Waters ; antibiotic resistance genes ; antimicrobial peptide (AMP) ; wastewater ; tertiary media filtration ; Psl ; antibiotic-resistant strains ; drinking water treatment plants ; water ; sediment ; surface water ; gastrointestinal infections ; Acinetobacter baumannii ; metal resistance genes ; metagenomics ; water reuse ; bacterial community ; antibiotics ; ERIC-PCR ; river-reservoir system ; the Yellow River ; ecological risk assessment ; aquatic environment ; wastewater treatment ; sand settling reservoirs ; antibiotic resistance gene ; environmental ecology ; antibiotic resistance ; ESBL ; water treatment plants ; Pseudomonas aeruginosa ; chlorination ; irrigation water ; exopolysaccharide ; fecal indicator bacteria ; Antimicrobial Resistance ; persistence ; Qingcaosha reservoir ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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  • 61
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: Model-informed precision dosing (MIPD) is an advanced quantitative approach focusing on individualized treatment optimization. MIPD integrates mathematical models of drugs and diseases combined with individual patient characteristics (e.g., genotype, anthropometric factors, and organ function). MIPD has been highlighted as a useful tool for drug dosage selection in both the drug development process and clinical practice and it is a rapidly growing discipline that is supported by the main drug regulatory agencies. Despite the potential benefits of this methodology toward personalized medicine, its application is still limited. The Special Issue presented here includes several PKPD and PBPK models focused on improving the current state of art regarding the PK behaviour of different drugs with the aim of improving the efficacy/safety balance of these treatments and their clinical outcome; the Special Issue is intended to be of particular interest for clinical pharmacologists, pharmacometricians, and specific clinicians who routinely use the considered drugs.
    Keywords: model-informed precision dosing (MIPD) ; efficacy PKPD indexes ; pharmacokinetics ; pharmacodynamics ; PKPD modeling and simulation ; dosing algorithms ; nomograms ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::K Economics, finance, business & management::KN Industry & industrial studies::KND Manufacturing industries::KNDP Pharmaceutical industries
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  • 62
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-09-11
    Description: Ionizing radiation (IR) exposure can be deleterious for living tissues and eventually lead to illness or even death. DNA breakdown and the overproduction of highly reactive free radicals, reactive oxygen species (ROS) and reactive nitrogen species (RNS) are considered initiators of IR-induced molecular and cellular damages, whereas NO, TGF-β and other pro-inflammatory cytokines are the primary effectors involved in radiation bystander effects (RIBE). Radiomodulators can reduce (radioprotectors and radiomitigators) or increase (radiosensitizers) IR damage. Past world events have highlighted the urgent need to develop predictive biomarkers of the IR absorbed dose and radiation countermeasures to reduce IR damage. Despite the strong economic and scientific efforts over the last decades, at present, drugs for effective protection against lethal IRs remain an unmet need. Moreover, the development of radiosensitizers that selectively increase IR damage in cancer cells but protecting, or at least do not affect, healthy tissues is also of unquestionable importance to improving patient survival and quality of life. It includes contributions that will help to understand the mechanisms involved in radiation-derived cellular responses and damage, the importance of free radical scavengers and antioxidant cellular defenses in preventing harm, and the relevance of the antiinflammatory response to improve recovery. In accordance, the mechanism of action and effectiveness of relevant radiomodulators are described and discussed, and novel clinical models and IR biomarker technologies are presented.
    Keywords: ferulic acid ; total body irradiation ; bone marrow microenvironment ; stem cell senescence ; bone marrow injury ; reactive oxygen species ; antioxidant defense system ; planarians ; model animal ; irradiation ; regeneration ; radioprotection ; radiation ; melatonin ; nDNA-repair ; mtDNA-mutations ; oxidation stress ; protection ; mitigation ; H2O2 ; ATP ; MDA ; GSH ; X-ray radiation ; 3T3 fibroblasts ; proliferation ; apoptosis ; cellular stress ; senescence ; peroxiredoxin 6 ; Prdx6 ; radioprotector ; pharmacologic ascorbate ; vitamin C ; pancreatic cancer ; Auranofin ; thioredoxin ; thioredoxin reductase ; peroxiredoxin ; nuclear and radiological emergencies ; radioprotectors ; radiomitigators ; radionuclide scavengers ; radiation biodosimetry ; Olea europaea L. cv. Caiazzana ; oleacein ; ionising radiation ; cancer ; radiotherapy ; normal tissue ; radiosensitization ; radiomodulation ; proteomic analysis ; oxidative modification profiling ; serum albumin ; amino acid sequences ; radiation biomarker ; human lactoferrin ; acute gamma irradiation ; C57Bl/6 mice ; survival rate ; open field test ; spleen ; serum homeostasis ; leukocytes ; stilbenoid ; electron paramagnetic resonance (EPR) ; FT-IR ; electron beam radiation ; radioresistance ; oxidative phosphorylation ; oncometabolites ; radiation response ; bioinformatics ; oxidative stress ; transcriptomics ; radiobiology database ; gene signature ; ionizing radiation ; intestine ; mucositis ; microbiome ; microbiota ; dysbiosis ; bacterial dietary supplement ; radiomitigator ; hyperthermia ; combination therapy ; synergistic effect ; oxygenation ; hypoxia ; immune response ; Tameron ; antioxidant ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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  • 63
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: As computer and space technologies have been developed, geoscience information systems (GIS) and remote sensing (RS) technologies, which deal with the geospatial information, have been rapidly maturing. Moreover, over the last few decades, machine learning techniques including artificial neural network (ANN), deep learning, decision tree, and support vector machine (SVM) have been successfully applied to geospatial science and engineering research fields. The machine learning techniques have been widely applied to GIS and RS research fields and have recently produced valuable results in the areas of geoscience, environment, natural hazards, and natural resources. This book is a collection representing novel contributions detailing machine learning techniques as applied to geoscience information systems and remote sensing.
    Keywords: TA1-2040 ; T1-995 ; n/a ; sport games ; compensatory eating ; breath test ; exercise-induced anorexia ; Fitbit ; nutrition education ; senescence ; body weight ; sport nutrition ; fitness ; long-term follow-up ; self-efficacy ; protein ; food consumption ; cytokines ; physical exercise ; cardiometabolic health ; mediation analyses ; obesity ; food choice ; telomere length ; sporting events ; carbohydrates ; free radicals ; marathon ; adolescents ; movement skills ; naturally enriched 13C-milk proteins ; behavioral intervention ; acute exercise ; skeletal muscle damage ; Protein ; TERRA ; nutrition ; telemonitoring ; Latino ; adolescent ; macronutrients ; metabolism ; mechanisms of impact ; anabolic competence ; endurance exercise ; food healthiness ; exercise ; health promotion ; behavioral economics ; immunity ; stunting ; lifestyle intervention ; running ; telomerase ; dietary intake ; inflammation ; vegetarian ; recreational athlete ; physical performance ; out-of-home eating ; diet ; overweight ; dietary restriction ; soccer ; dual burden of malnutrition ; protein shake ; childhood memories ; chronic diseases ; music events ; oxidation ; added sugar ; lifestyle change ; vegan ; nudges ; food ; physical activity ; half-marathon ; health conscious ; free or reduced lunch ; low-income ; diet quality ; National School Lunch Program ; older adults ; aging ; sport spectators ; chronic low-grade systemic inflammation ; sport ; food intake ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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  • 64
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: This Special Issue on “Blood-Derived Products for Tissue Repair and Regeneration” reveals the evolution and diversity of platelet rich plasma (PRP) technologies, which includes experimental research on novel formulations, the creation of combination therapies, and the exploration of potential modifiers of PRPs, as well as efficacy of PRP therapies in clinical veterinary and human applications. Scientist and clinicians are now starting to develop different treatments based on their reinterpretation of the traditional roles of platelets and plasma, and the current Issue has provided a forum for sharing research and ways of understanding the associated medicinal benefits from different points of view. The research interest in this area has covered different medical disciplines, such as ophthalmology, dentistry, orthopedics, and sports medicine.
    Keywords: R5-920 ; RM1-950 ; n/a ; biomaterial ; redifferentiation ; regenerative medicine ; skeletal muscle regeneration ; furcation defects ; Platelet-Rich Plasma (PRP) ; PRP ; fracture ; fibrin sealant ; periodontal surgery ; bone regeneration ; serum derived from plasma rich in growth factors (s-PRGF) ; cartilage repair ; myofibroblasts ; autologous platelet concentrates ; burns ; satellite cells ; articular cartilage ; stem cell niche ; wound healing ; quantification ; growth factors ; biologics ; platelet rich plasma ; meniscus ; adipose tissue ; Carprofen ; platelet-rich fibrin ; platelets ; hyperacute serum ; bone defects ; serum eye drops ; corneal epithelial defect ; fibrosis ; dog ; myoblasts ; differentiation ; chronic meniscal lesion ; horizontal meniscal tear ; PRGF ; collagen hydrogels ; periodontal defects ; bone grafting material ; composition ; cell therapy ; bone healing ; tissue healing ; trephination ; plasma rich plasma (PRP) ; bone repair ; plasma rich in growth factors ; knee arthrosis ; meniscus tear ; cornea regeneration ; wrist osteoarthritis ; periosteal sheet ; Platelet-Poor Plasma (PPP) ; platelet-rich plasma ; microfat ; bone grafting ; hyaluronic acid (NaHA) ; periodontal regeneration ; meniscus repair ; photobiomodulation therapy ; growth ; myogenesis ; blood derived products ; low-level laser therapy ; bic Book Industry Communication::M Medicine
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  • 65
    Publication Date: 2023-12-21
    Description: Looking at "Horse in Motion", the iconic photograph by E. Muybridge, it is almost possible to hear the horse galloping. The pounding sound of the hoofs hitting the ground -like a drum- can also echo the rythmic beating of the human heart. That sound, that visceral rhythm, reminds us of the link between motion and performance: the perfectly executed stride of the horse, the incredible coordination of multiscale phenomena behind a heart beat. Furthermore, the decomposed sequence in Muybridge's photograph has become a well-known example of breaking motion into its components over time, and as such is reminiscent of those images that are routinely acquired in clinical practice, where the heart appears dilating and shirnking in a sequence of snapshots. The investigation of this motion and its subtleties is essential for refining our understanding of cardiac function, and the appreciation of how and when this motion is no longer perfectly executed can lead us to understand functional impairments and provide insight into the unfolding of pathology. In the presence of congenital heart disease (CHD), cardiac mechanics are altered: from single ventricle physiology to conduction abnormalities to different cardiomyopathies, it is important to both capture and interpret biomechanical changes that occur in the presence of a congenital defect. This special issue in Frontiers in Pediatrics, now an e-book, focuses on 'Ventricular mechanics in congenital heart disease' and looks at current knowledge of phenomena such as systolic/diastolic dysfuction and current methods (chiefly in cardiovascular magnetic resonance imaging and echocardiography) to evaluate cardiac function in the presence of CHD, and then presents a series of original studies that employ both medical imaging and computational modelling techniques to study specific CHD scenarios.
    Keywords: R5-920 ; RJ1-570 ; cardiovascular magnetic resonance imaging ; ventricular mechanics ; Congenital Heart Diseases ; hypoplastic left heart syndrome ; diastolic function ; computational modelling ; systolic function ; haemodynamics ; bic Book Industry Communication::M Medicine
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  • 66
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-05-06
    Description: Chronic intestinal diseases are increasing around the world. With poor quality of life and expensive healthcare costs, the patients demand novel approaches and treatments for better clinical outcomes. This book illustrates the state of the art and the envisaged near future in the management of these pathologies.
    Keywords: chronic intestinal pseudo-obstruction ; parenteral nutrition ; pediatrics ; myopathy ; neuropathy ; IBS ; microbiota ; visceral hypersensitivity ; colorectal motility ; inflammatory bowel disease ; Crohn’s disease ; ulcerative colitis ; anti-TNF ; ustekinumab ; vedolizumab ; postoperative complications ; surgery ; preoperative therapy ; biologic therapy ; bio-naïve ; IBD ; pro-inflammatory cytokines ; lymphocyte migration ; treatment ; inflammatory bowel diseases ; biologic treatment ; combination ; n/a ; bic Book Industry Communication::M Medicine
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  • 67
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: This reprint contains articles published in the Special Issue entitled "Assessing Atmospheric Pollution and Its Impacts on the Human Health" in the journal Atmosphere. The research focuses on the evaluation of atmospheric pollution by statistical methods on the one hand, and on the other hand, on the evaluation of the relationship between the level of pollution and the extent of its effect on the population's health, especially on pulmonary diseases.
    Keywords: household air pollution ; fine particulate matter ; international environmental health ; cookstove ; respiratory disease ; brick worker ; particulate matter ; heavy metals ; Sulfate-Nitrate-Ammonium ; pollution levels ; mobile sources ; aerosols ; PAHs ; OC and EC ; transport sources ; urbanized coastal station ; grain dust ; health risk assessment ; Monte Carlo simulation ; disability adjusted life year ; multi-media exposure ; health risk ; probabilistic risk assessment ; Lake Chaohu ; PM10 ; health risks ; extreme learning machine ; echo state network ; neural networks ; pollution ; concentration ; indicators ; aberrant values ; nitrogen oxides ; ARIMA ; GRNN ; ARIMA–GRNN ; isolation forest ; LOF ; AOD ; classification ; dendrogram ; PCA ; air quality index ; polluting agents ; respiratory diseases ; monitoring stations ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology::MMGT Medical toxicology
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  • 68
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-06-21
    Description: This Special Issue is aimed to offer an overview of studies presenting new rehabilitation approaches addressed to children with neurodevelopmental disorders, designed to enhance the effects of learning processes through the use of new technologies. The contributions of this Special Issue, authored by researchers and clinicians from some of the most valued Italian scientific institutions in the field of neurodevelopmental disorders, can offer some useful data and advice on the use of technology in rehabilitation and telerehabilitation to researchers, rehabilitators, clinicians and pratictioners (psychologists, neuropsychologists, speech therapists, etc.).
    Keywords: neurorehabilitation ; cognitive enhancement in children ; tech mediated rehabilitation ; developmental coordination disorders ; virtual reality ; telerehabilitation ; specific learning disorders ; cerebral palsy ; well-being ; dyslexia ; rhythm ; music therapy ; intervention ; developmental dyslexia ; new technologies ; augmented reality ; good practices ; Delphi method ; rehabilitation ; remote intervention ; children ; age ; severity ; improvement ; follow-up ; n/a ; bic Book Industry Communication::M Medicine
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  • 69
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-05-11
    Description: There has been a rapid development in the academic literature over the last ten years on papers relating to individualization, personalization, patient-, client-, consumer- and person-centredness, with work on conceptual, instrumental, observational, and experimental levels. This Special Issue presents papers that can further establish the current state of science on these topics relating to personalized nursing and health care. We collected papers that highlight and further the knowledge base conceptually, instrumentally, observationally, and experimentally with sound theoretical and methodological underpinnings and implications for research, theory, and clinical work in the disciplines of nursing, medicine, allied health, and beyond.
    Keywords: anxiety ; life satisfaction ; life–work concerns ; melatonin ; cortisol ; biopsychosocial model ; obstetric complications ; patients’ rights ; student ; nursing ; personalized medicine ; HIV ; mobile health ; smartphone application ; symptom management ; nurse practitioners ; nursing home ; COVID-19 ; palliative care ; end-of-life ; dignified death ; older adults ; accidental falls ; fall prevention ; barriers ; patient compliance ; music therapy ; dementia ; caregiver ; RCT ; patient-centred care ; competence ; assessment ; instrument ; measurement ; validity ; reliability ; individual care ; nurses ; older diabetes patients ; physicians ; support ; Parkinson’s disease ; nursing training ; integrated care ; Parkinson nurse ; personalized care ; multidisciplinary care ; patient-centered ; arthritis ; autoimmune disease ; sociopsychological factors ; emotion ; depression ; self-identity ; qualitative study ; observational study ; dysmenorrhea ; kinesio tape ; auricular acupressure ; pain ; nursing care ; patient care planning ; quality of health care ; conditional inference trees ; education ; distance ; learning ; digital ; drawings ; Nigeria ; perinatal loss ; social networks ; stillbirth ; stillborn ; functional status ; health care ; hospitalization ; activities of daily living ; pelvic floor muscle exercises ; pelvic floor dysfunction ; qualitative research ; therapeutic exercise ; therapeutic adherence ; women’s health physiotherapy ; diabetes mellitus type 2 ; prediction model ; LogicRegression ; interpretability ; pelvic organ prolapse ; lifestyle changes ; women’s experience ; n/a ; foot ; foot self-care ; methodological review ; bic Book Industry Communication::M Medicine
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  • 70
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-03-07
    Description: Dry pasta is one of the most popular staple foods worldwide due to its convenience in terms of affordability, versatility, long shelf life, as well as sensory and nutritional value. As such, it represents a suitable carrier for health-promoting substances providing specific physiological functions. This Special Issue deals with the continuum aspects, “from seed to fork”, that could have an impact on the nutritional, sensory, and technological aspects of pasta. In this Special Issue, we aimed to publish innovative research and review papers on physico-chemical and sensorial characteristics, nutritional value, functional and technological properties of pasta, and pasta-making processes. New raw materials, new functional ingredients, up-cycling of waste materials, in vivo experiments to test the effect of assumption of the supplemented pasta, and innovative packaging systems will also be addressed in this Special Issue. Predictions of pasta quality adopting chemometrics as well as multi-variate and statistical data analysis approaches were welcomed. Finally, in the medium term, the international pasta market is expected to stay negative unless tangible product innovations are introduced, particularly regarding the technological innovations aimed at improving the products’ health benefits. This Special Issue aimed to provide a fundamental understanding and present the current strategies to improve the technological, nutritional, and sensory properties of pasta.
    Keywords: innovative pasta raw materials ; durum ; emmer ; spelt ; pasta ; brewers’ spent grain ; dietary fiber ; einkorn ; functional pasta ; tritordeum ; upcycling ; unconventional ingredients ; nutritional value ; cooking quality ; legumes ; Spirulina Platensis ; resistant starch ; hydrolysis index ; dietary fibre ; annealing ; slowly digestible starch ; carbohydrates ; fiber ; in vitro digestion ; micronization ; brown rice ; air fractionation ; parboiling ; rice pasta ; enriched pasta ; bioactive compound ; tuna ; sea bass ; Ω-3 fatty acids ; sensometrics ; TPA (texture profile analysis) ; glycemic index ; glycemic response ; durum wheat ; landraces ; starch ; available carbohydrates ; glycemic load ; texture profile analysis ; gluten-free ; celiac disease ; fish ; allergy ; pear, date, and apple by-products ; wheat flour ; sensorial properties ; scanning electron microscopy ; multiple factor analysis ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MB Medicine: general issues::MBP Health systems & services::MBPK Mental health services
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  • 71
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Liquid Crystal on Silicon (LCoS) has become one of the most widespread technologies for spatial light modulation in optics and photonics applications. These reflective microdisplays are composed of a high-performance silicon complementary metal oxide semiconductor (CMOS) backplane, which controls the light-modulating properties of the liquid crystal layer. State-of-the-art LCoS microdisplays may exhibit a very small pixel pitch (below 4 ?m), a very large number of pixels (resolutions larger than 4K), and high fill factors (larger than 90%). They modulate illumination sources covering the UV, visible, and far IR. LCoS are used not only as displays but also as polarization, amplitude, and phase-only spatial light modulators, where they achieve full phase modulation. Due to their excellent modulating properties and high degree of flexibility, they are found in all sorts of spatial light modulation applications, such as in LCOS-based display systems for augmented and virtual reality, true holographic displays, digital holography, diffractive optical elements, superresolution optical systems, beam-steering devices, holographic optical traps, and quantum optical computing. In order to fulfil the requirements in this extensive range of applications, specific models and characterization techniques are proposed. These devices may exhibit a number of degradation effects such as interpixel cross-talk and fringing field, and time flicker, which may also depend on the analog or digital backplane of the corresponding LCoS device. The use of appropriate characterization and compensation techniques is then necessary.
    Keywords: TA1-2040 ; T1-995 ; n/a ; aberration compensation ; holographic and volume memories ; achromatic lens ; head-up displays ; phase characterization ; holographic display ; spatial resolution ; spatial light modulator ; zoom lens ; soliton ; transmission matrix ; head-mounted displays ; diffraction ; parallel-aligned ; liquid-crystal on silicon ; phase measurement ; multimode fiber ; digital holography ; chromatic aberration ; multiorder diffractive lens ; holography ; phase accuracy ; interference ; computer generated hologram ; optical manipulation ; speckle suppression ; phase modulation ; transparent mode ; light scattering ; ferroelectric ; phase change ; liquid-crystal-on-silicon ; imaging systems ; Liquid Crystal on Silicon display ; diffractive optical element ; liquid crystals ; spatially anamorphic phenomenon ; calibration ; head-up display ; helix-free ; phase precision and stability ; kinoform ; spatial light modulators ; photopolymer ; diffractive optics ; mode division multiplexing ; liquid crystal on silicon device ; augmented reality displays ; holographic data storage ; liquid crystal spatial light modulator ; harmonic lens ; fringing field effect ; liquid crystal ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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  • 72
    Publication Date: 2023-12-21
    Description: Natural antibodies (NAbs) are found in normal individuals in the absence of exogenous antigenic stimulation. Natural antibodies rapidly recognize and protect against pathogens that have not been previously encountered. NAbs also cross-react with several self-antigens, which, besides their role as a first line of defense against pathogens, affords them the ability to perform important housekeeping functions in healthy organisms. Such housekeeping functions include the clearance of oxidized damaged structures and/or apoptotic cells, which prevents the induction of pro-inflammatory effects. In addition, NAbs play a role in preventing the expansion of specific auto-reactive clones, thereby behaving as regulatory elements in acute or chronic inflammation. To maintain the non-pathogenic balance between the dual pathogen/self-antigen cross-reactivities of NAbs, a strict regulation in NAb secretion and function is necessary to avoid autoimmune disease. Actually, some of the NAbs related auto-reactivities, such as anti-DNA and anti-MOG, have been associated with autoimmunity. Furthermore, NAbs have been shown to bind to ‘neo-self’ carbohydrate antigens on glycolipids and glycoproteins found on malignant but not normal cells, which suggests NAbs may take part in tumor immunosurveillance. Many aspects regarding NAbs have yet to be studied in more detail: the reactivity and function of NAbs in health and disease, the behavior of the NAb repertoire with increasing age, the regulation of natural antibody production and auto-reactivity, the ways to specifically activate NAbs producing cells with desired specificities, the characteristics of human NAbs, among others. This special topics eBook consists of a number of articles exploring the cells that produce NAbs as well as the characteristics, function, specificity, and/or the role of natural antibodies in health and disease.
    Keywords: R5-920 ; RC581-607 ; innate immunity ; immunoglobulin ; Antibodies ; B cells ; IgM ; natural antibodies ; B-1 cells ; bic Book Industry Communication::M Medicine
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  • 73
    Publication Date: 2023-12-21
    Description: The discovery of the negative feedback of thyroid hormones on pituitary thyroid-stimulating hormone (TSH) secretion, a classical endocrine feedback control system, has shaped diagnosis and treatment of thyroid disease for the last decades. Based on this concept, a unique diagnostic category of subclinical thyroid disorders was introduced, being defined exclusively by an abnormal TSH response in the presence of thyroid hormone concentrations within the reference range. Although this approach was able to deliver a conceptually straightforward disease definition problems surfaced in clinical practice as neither the diagnostic reference range nor the appropriate threshold for initiating substitution treatment are universally agreed upon for subclinical thyroid disorders. The situation is further aggravated by the so-called syndrome T, which comprises a substantial but heterogeneous group of L-T4 treated patients with hypothyroidism with reduced quality of life despite “normal” TSH values.〈/p〉〈p〉A limited understanding of the physiological relationships between TSH and thyroid hormones may be a main reason for clinical difficulties in dealing with the causes of syndrome T and tailoring substitution therapy for hypothyroid patients with subclinical thyroid disorders. 〈/p〉〈p〉Feedback regulation has recently been shown to be much more complex than previously assumed. The concept of homeostatic control has also been extended to include the lesser known but equally important allostatic thyroid regulation.The latter aims at adaptive homeostasis or stability through changing setpoints and modulating structural parameters of feedback control, as may be appropriate to adapt to a vast array of conditions spanning from fetal life, aging, pregnancy, exercise, starvation, obesity, psychiatric disorders to the severe non-thyroidal illness syndrome.〈/p〉〈p〉A better understanding of homeostatic and allostatic mechanisms, which govern the behaviour of pituitary-thyroid feedback control, is on the horizon. This promises to improve the diagnostic utility of laboratory methods, laying the foundation for personalised methods to optimise dosage and modality of substitution therapy. The emerging new world of thyroid physiology is reflected on the side of clinical medicine in a new, relational paradigm for diagnosis and treatment.〈/p〉〈p〉Considerable progress has been made in this respect in the following key areas:〈/p〉〈p〉• the significance of complementary information processing structures within the feedback loop, in particular ultrashort feedback of TSH on its own secretion and the action of a TSH-T3 shunt unburdening the thyroid from T4 synthesis in imminent thyroid failure,〈/p〉〈p〉• the unravelling of spatio-temporal dynamics of hormone concentrations ranging from ultradian to circannual rhythms and including hysteresis effects,〈/p〉〈p〉• the emergence of “non-canonical” mechanisms of thyroid hormone signalling beyond transcriptional control of gene expression,〈/p〉〈p〉• the physiological actions of thyronine metabolites, which have been previously regarded as biologically inactive, such as thyronamines and iodothyroacetates,〈/p〉〈p〉• the characterisation of distinct patterns in the adaptive processes to stress and strain and their conclusive explanation through reactions to type 1 and type 2 allostatic load.〈/p〉〈p〉This collective volume contains the contributions to the Research Topic “Homeostasis and Allostasis of Thyroid Function”, which was originally published by the journal Frontiers in Endocrinology. Authored by an international team of experts from three continents ,the book provides a comprehensive overview on thyroid control from recent research in basic, computational and clinical thyroidology. Many aspects addressed here can be expected to stimulate future research. A more comprehensive view and better integration of in-vitro, in-silico and in-vivo investigations will be invaluable in paving the way to this new world of thyroidology.
    Keywords: R5-920 ; RC648-665 ; relational stability ; Thyronamines ; TSH-T3 Shunt ; thyroid allostasis ; precision medicine ; Stratified Medicine ; 3-T1AM ; Hypothyroidism ; Thyroid homeostasis ; Hysteresis ; bic Book Industry Communication::M Medicine
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  • 74
    Publication Date: 2023-12-21
    Description: Developing novel and more effective treatments that improve quality of life for individuals with autism spectrum disorders is urgently needed. To date a wide range of behavioral interventions have been shown to be safe and effective for improving language and cognition and adaptive behavior in children and adolescents with ASD. However many people with ASD can receive additional benefit from targeted pharmacological interventions. One of the major drawback in setting up therapeutics intervention is the remarkable individual differences found across individuals with ASD. As a matter of fact the medications that are currently available address only symptoms associated with ASD and not the core domains of social and communication dysfunction. The pathogenesis paradigm shift of ASD towards synaptic abnormalities moved the research to pathway to disease that involve multiple systems and that are becoming the forefront of ASD treatment and are pointing toward the development of new targeted treatments. Some new therapeutics have been tested and others are being studied. In this context single gene disorders frequently associated with ASD such as Rett Syndrome, Fragile X and Tuberous Sclerosis have been of significant aid as neurobiology of these disorders is more clear and has a potential to shed light on the altered signaling in ASD. However much research is needed to further understand the basic mechanisms of disease and the relationship to idiopathic ASD. Clinical trials in children are underway with agents directed to core symptoms and to the associated disorders in the search of new therapeutics and progress are expected with possible new option for therapeutics in ASD in the upcoming future. Children and Adolescents with ASD and their families can provide important information about their experience with new treatments and this should be a priority for future research. In addition, research performed on genetic mouse models of ASD will keep on providing useful information on the molecular pathways disrupted in the disease, thus contributing to identify novel drug targets.
    Keywords: R5-920 ; RJ1-570 ; Clinical Trial ; mouse model ; neurodevelopmental disorder ; Genetics ; autism ; bic Book Industry Communication::M Medicine
    Language: English
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  • 75
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: This reprint contains several articles where the molecular mechanisms and structural changes in target proteins on interaction with various viruses and bacteria were studied. In addition, drug-protein interactions, drug–drug interaction mechanisms, anti-Glycating, antioxidant, binding affinity, network pharmacology-driven investigations, and targeted anticancer treatments were also investigated.
    Keywords: RSV ; ectodomain G protein ; heparan sulfate ; protein–ligand interaction ; fluorescence quenching ; molecular docking ; molecular dynamic simulation ; quercetin ; CCL4 ; neurotoxicity ; VirtualToxLab ; oxidative stress markers ; Huperzine A ; molecular dynamics simulation ; fluorescence spectroscopy ; human serum albumin ; neurodegenerative disorders ; drug–protein interactions ; erlotinib ; bovine serum albumin ; binding interaction ; competition ; hepatitis E virus ; methyltransferase ; protein stability ; enzyme assay ; garlic ; antioxidant ; anti-glycation ; glycation ; AGEs ; HSA ; quetiapine ; hydrophobic interaction ; thermodynamic parameters ; seproxetine ; antidepressant ; charge transfer ; π-acceptors ; DFT ; haloperidol ; antipsychotics ; keratoconus ; MMP-2 ; MMP-9 ; molecular dynamics ; MM-GBSA calculations ; pharmacophore mapping ; α-amylase ; advanced glycation end-products ; caffeic acid ; coumaric acid ; coronary artery disease ; phytotherapy ; network pharmacology ; angiogenesis ; zebrafish ; dynamics molecular docking ; NEK7 ; virtual screening ; DFTs ; deep learning ; drug design ; drug repurposing ; structural-based ; cancer ; A. aspera ; β-amyrin ; C. gigantea ; C. procera ; GC-MS ; Minimum inhibitory concentration (MIC) ; Molecular docking ; MD simulations ; Tuberculosis (TB) ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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  • 76
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: This special feature issue has been initiated to celebrate the 25th anniversary of Optical Coherence Tomography (OCT). In OCT, broad bandwidth light is used in order to produce cross sectional images of turbid and translucent samples with high axial resolution (in the order of a few µm). The imaging speed of OCT can be as high as several millions of depth scans (A-scans) per second which allows for various applications in different fields. This special feature issue consists of three overview papers covering OCT angiography, polarization-sensitive OCT and dental applications of OCT. Additional applications and the latest developments in OCT are covered in nine research papers. The latest developments presented in this issue include magnetomotive OCT, resonant Doppler OCT, full field OCT, new segmentation algorithms and depth range extension. Applications of OCT are widely spread and range from quality control in tooth prostheses and coating thickness measurements in the automotive industry to the assessment of degradation of coatings and alveolar dynamics.
    Keywords: TA1-2040 ; Biomedical Engineering ; Optical Coherence tomography ; Polarization ; Angiography ; Optics ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
    Language: English
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  • 77
    Publication Date: 2023-12-21
    Description: Population aging and the associated burden of chronic diseases are one of the main challenges in public health worldwide. This Research Topic on "Active Aging and Disease Management" provides a comprehensive overview of population aging through fourteen comprehensive papers. Chapter 1 discusses an overview of health systems in active and healthy aging, while Chapter 2 focuses on the role of lifestyles, exercise and new technologies. Chapter 3 debates psychological and cognitive issues in aging and finally in Chapter 4, an older people self assessment is proposed and the role of communities and supporters are highlighted. We think that real social and health care integration at community level could be the key point to deliver effective health promotion and preventive intervention. Enjoy the reading!
    Keywords: R5-920 ; preventing disability ; dietary intake ; Active aging ; chronic diseases ; Life styles ; Mental Health ; Disease Management ; New technologies ; Elderly ; physical activity ; bic Book Industry Communication::M Medicine
    Language: English
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  • 78
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-02-01
    Description: The concept of advanced therapy medicinal products (ATMPs) encompasses novel kinds of medicines for human use that are based on genes, cells or tissues. These intend to offer not only regeneration, but complete functional recovery of diseased tissues and organs using different strategies. Gene therapy, cell therapy and tissue engineering are the main areas in which promising advanced therapies are emerging. The eye is a very complex organ whose main structures, the cornea and the retina, play a pivotal role in maintaining normal vision, as severe alterations in these tissues can lead to blindness. Ocular tissues are starting to benefit from ATMPs by fighting against the enormous complexity and devastating potential of many ocular diseases. However, developments arising from this field of work face important challenges related to vectors to deliver drugs and genetic material to target tissues, suitable biomaterials to prepare cell scaffolds and cell stemness, among others—not to mention the complicated legislation around ATMPs, the complexity in production and quality control and the absence of standardized protocols.The purpose of this Special Issue is to serve as an overview of the current progress in the application of cell and gene therapies, as well as tissue engineering to restore functionality in diseased ocular structures, and the challenges linked to reaching patients.
    Keywords: MPC polymer ; dry eye ; ocular surface ; lacrimal fluid ; mucin ; 3D bioprinting ; cornea ; retina ; ophthalmology ; tissue regeneration ; electrospinning ; conjunctiva ; decellularized tissue matrix ; small intestinal submucosa ; urinary bladder matrix ; polycaprolactone ; fiber ; tissue engineering ; stratification ; conjunctival epithelial cells ; hydrogel ; keratoplasty ; scaffold ; collagen ; advanced therapy medicinal product ; ATMP ; cell therapy ; gene therapy ; eye ; ocular ; regulatory ; marketing authorization ; double-crosslinking ; carbodiimide ; glutaraldehyde ; sodium metabisulfite ; sodium borohydride ; EDC/NHS ; stem cells ; retinal diseases ; optic nerve diseases ; cell replacement ; cell sources ; advanced therapies ; ocular mucosa ; blindness ; CLET ; limbal niche ; limbal stem cell ; LSCD ; mesenchymal stem cell transplantation ; MSCT ; corneal limbus ; decellularized xenograft ; recellularization ; mesenchymal stem cells ; n/a ; bic Book Industry Communication::M Medicine
    Language: English
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  • 79
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: The extraction of apatite minerals is becoming more and more crucial with the depletion of high-grade ores. At the same time, many streams of waste are continuously being produced by the phosphate industry, including calcareous and siliceous waste rocks, clayey sludge and phosphogypsum. These waste products are produced in huge volumes reaching a ratio of between 5 to 10 tons of waste per each ton of concentrated phosphate. The management of these waste products is becoming a real issue in terms of growing public awareness and environmental and financial aspects. In addition, phosphate ores are known to contain other critical raw materials (CRM) such as rare earth elements and uranium. The recovery of these vital elements from phosphate waste may help to develop the needs of the green energy of the future and contribute to the achievement of the sustainable development goals. In this Special Issue, insights related to the following aspects were studied: phosphate extraction and beneficiation, novel phosphate ores, the fine characterization of phosphate ores and waste, phosphoric acid production, critical raw material (CRM) recovery from phosphate ores and waste, reprocessing of phosphate wastes and finally the valorization and reuse of phosphate waste and phosphogypsum.
    Keywords: TA1-2040 ; T1-995 ; TN1-997 ; n/a ; valorization ; ceramic membrane ; general industrial solid waste ; cemented paste backfill ; cemented phosphogypsum backfill ; unconfined compressive strength ; mineralogy ; froth flotation ; silicate-carbonate gangue ; geochemical characteristic ; activity concentration ; building materials ; valuable elements ; upgrading ; radiological influence ; durability ; phosphogypsum ; phosphate ore processing ; low-grade phosphate ; industrial waste ; phosphogypsum (PG) ; filtration ; civil engineering ; comprehensive utilization ; phosphorite ; flotation ; REE recovery ; phosphate mine waste rocks ; Gafsa-Metlaoui Basin ; acid extraction ; rare earth elements ; drying-wetting cycles ; column flotation ; slimes ; collector ; phosphate mine tailings ; apatite ; purification ; REE-bearing phases ; weathered ore ; water washing ; depressant ; environment behavior ; experimental design ; interfering ions ; technological mineralogy ; red mud ; rare earth elements (REEs) ; waste management ; phosphate ore ; waste recycle ; natural radioactivity ; natural aggregates ; phosphate ; beneficiation ; beneficiation tailings ; road techniques wet process ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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  • 80
    Publication Date: 2023-12-21
    Description: There is abundant evidence showing a strong association between trauma exposure, psychotic symptoms, and posttraumatic stress disorder (PTSD). Early trauma exposure contributes to the formation of psychotic symptoms and the development of psychotic disorders or severe mental illnesses such as schizophrenia, bipolar disorder, and treatment-refractory major depression. Furthermore, among persons with psychotic disorders, multiple traumatization over the lifetime is common, due to factors such as social stigma, the criminalization of severe mental illness, and increased vulnerability to interpersonal victimization. In addition to these factors is the traumatic nature of experiencing psychotic symptoms and coercive treatments such as involuntary hospitalization and being placed in seclusion or restraints. Not surprisingly, these high rates of trauma lead to high rates of PTSD in people with psychotic disorders, which are associated with more severe symptoms, worse functioning, and greater use of acute care services. In addition to the impact of trauma on the development of psychotic disorders and comorbid PTSD, traumatic experiences such as childhood sexual and physical abuse can shape the nature of prominent psychotic symptoms such as the content of auditory hallucinations and delusional beliefs. Additionally, traumatic experiences have been implicated in the role of ‘stress responsivity’ and increased risk for transition to psychosis in those identified as being at clinical high risk of developing psychosis. Finally, although the diagnostic criteria for PTSD primarily emphasize the effects of trauma on anxiety, avoidance, physiological over-arousal, and negative thoughts, it is well established that PTSD is frequently accompanied by psychotic symptoms such as hallucinations and delusions that cannot be attributed to another DSM-V Axis I disorder such as psychotic depression or schizophrenia. Understanding the contribution of traumatic experiences to the etiology of psychosis and other symptoms can inform the provision of cognitive behavioral therapy for psychosis, including the development of a shared formulation of the events leading up to the onset of the disorder, as well as other trauma-informed treatments that address distressing and disabling symptoms associated with trauma and psychosis. Until recently the trauma treatment needs of this population have been neglected, despite the high rates of trauma and PTSD in persons with psychotic disorders, and in spite of substantial gains made in the treatment of PTSD in the general population. Fortunately, progress in recent years has provided encouraging evidence that PTSD can be effectively treated in people with psychotic disorders using interventions adapted from PTSD treatments developed for the general population. In contrast to clinician fears about the untoward effects of trauma-focused treatments on persons with a psychotic disorder, research indicates that post-traumatic disorders can be safely treated, and that participants frequently experience symptom relief and improved functioning. There is a need to develop a better understanding of the interface between trauma, psychosis, and post-traumatic disorder. This Frontiers Research Topic is devoted to research addressing this interface.
    Keywords: R5-920 ; RC435-571 ; BF1-990 ; Q1-390 ; Psychosis ; PTSD ; Auditory Hallucinations ; Negative Symptoms ; Childhood Trauma ; Trauma ; Psychological Interventions ; Lived Experience ; bic Book Industry Communication::M Medicine
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  • 81
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-08-12
    Description: The scope of the Special Issue is research and reviews on evaluations of current practice, innovations in medication management, developments in therapeutics, and pharmaceutical science research that informs and improves practice and administration, as well as the social and administrative pharmacy. We will mainly feature original research, reviews, short reports, and clinical studies, but also case reports, descriptive/how-to, and commentary submissions for consideration.
    Keywords: older adults ; polypharmacy ; internal medicine ward ; community pharmacy ; drug disposal ; unused medication ; environment ; awareness ; practice ; ambulatory care facilities ; health workforce ; pharmacists ; Taiwan ; Commonwealth Partnerships for Antimicrobial Stewardship (CwPAMS) ; National Health Service (NHS) ; Chief Pharmaceutical Officer’s Global Health Fellowship ; CPhOGH Fellows ; CwPAMS ; pharmacy ; fellowship ; health partnerships ; antimicrobial resistance (AMR) ; global health ; leadership ; non-prescription medicines ; emergency contraception ; community pharmacies ; information gathering ; availability ; pricing ; mystery calls ; ulipristal acetate ; levonorgestrel ; Germany ; e-prescription ; prescription writing ; Jazan ; Saudi Arabia ; prescription errors ; medicine consumption ; defined daily dose ; adolescents and young adults ; cancer patients ; fragility ; pain ; MUR ; medication review ; barriers ; pharmacist ; pregabalin ; abuse ; community pharmacists ; reproductive health ; contraception ; emergency contraceptives ; patient education ; biosensing technology ; digital medicine system ; medication adherence ; medication event monitoring system ; nonadherence ; prescription opioids ; mortality ; standardized mortality ratio ; underlying cause of death ; prescriptions ; community pharmacy services ; emergency prescribing ; pharmacy practice ; pharmacy law and regulation ; COVID-19 ; additional monitoring ; black triangle ; adverse event reporting ; pharmacovigilance ; intervention ; outcomes ; systematic review ; pharmacy education ; decision to study in pharmacy ; selecting pharmacy as a first choice ; pharmacogenomics ; learning activity ; asynchronous learning ; virtual learning ; student survey ; Program of All-Inclusive Care for the Elderly ; adverse drug events ; medication-related problems ; drug-related problems ; medication safety ; Medicare ; Medicaid ; financial management ; pharmacy management ; business ; entrepreneurship ; pharmacy students ; perception ; attitudes ; ability ; interprofessional ; simulation ; acute care ; nursing ; students ; standardized patients ; high fidelity ; SPICE-R2 ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::K Economics, finance, business & management::KN Industry & industrial studies::KND Manufacturing industries::KNDP Pharmaceutical industries
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  • 82
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: This special issue collects selected papers about a wide range of innovative applications in earthquake engineering. These studies were presented during the 2nd Edition of the International Workshop “Traditional and Innovative Approaches in Seismic Engineering”, held in Pisa in March 2017. The topics refer to the investigation of traditional and innovative materials for earthquake engineering applications: masonry, reinforced concrete, steel, structural glass and timber. In particular, advanced analytical and numerical analyses are described for considering effects of strength and material irregularities and rocking behavior under seismic excitations on historic buildings and industrial facilities. Experimental tests are also illustrated with the purpose of investigating the strengthening on masonry arches due to lime-based mortar composites and of obtaining reliable values of stiffness for moment resisting steel-timber connections. Among the innovative approaches, studies on original pavilions made of long-spanned TVT-portals braced with hybrid glass-steel panels are illustrated
    Keywords: TA1-2040 ; design ; seismic ; builings ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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  • 83
    Publication Date: 2023-12-21
    Description: The brainstem-limbic regions, including the superior colliculus, pulvinar and amygdala, receive direct perceptual information as a rapid, coarse, subcortical sensory system bypassing early sensory cortical systems, and play a central role in innate behaviors, including motivated and avoidance behaviors. Recent human neuropsychological studies including those on cortical blindness suggest that these subcortical sensory pathways are functional in the intact human brain and interact with more evolutionary recent cortical systems. This eBook presents up-to-date advancements in this area and to highlight the functions of the brainstem-limbic regions in a variety of perceptual, cognitive, affective and behavioral domains. We hope that this current Research Topic provides a comprehensive review to understand roles of the subcortical brainstem-limbic regions in some forms of sensory-motor coupling, cognitive and affective functions.
    Keywords: R5-920 ; RC321-571 ; RC435-571 ; BF1-990 ; Q1-390 ; Subcortical visual pathway ; Saccades ; Amygdala ; Pulvinar ; Superior colliculus ; Limbic system ; Cognition ; Emotion ; Faces ; Reward and aversion ; bic Book Industry Communication::M Medicine
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  • 84
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: This Special Issue presents the latest advances in the field of Textile-Reinforced Cement Composites, including Textile-Reinforced Concrete (TRC), Textile-Reinforced Mortar (TRM), Fabric-Reinforced Cementitious Matrix (FRCM), etc. These composite materials distinguish themselves from other fibre-reinforced concrete materials by their strain-hardening behaviour under tensile loading. This Special Issue is composed of 14 papers covering new insights in structural and material engineering. The papers include investigations on the level of the fibre reinforcement system as well as on the level of the composites, investigating their impact and fatigue behaviour, durability and fire behaviour. Both the strengthening of existing structures and the development of new structural systems such as lightweight sandwich systems are presented, and analysis and design methods are discussed. This Special Issue demonstrates the broadness and intensity of the ongoing advancements in the field of Textile-Reinforced Cement composites and the importance of several future research directions.
    Keywords: TA1-2040 ; T1-995 ; practical application ; fabric reinforced cementitious mortar ; tensile strength ; carbon concrete composite ; TRC ; cement composites ; model calibration ; micro-fiber ; textile reinforced cementitious composites (TRC) ; alkaline environment ; test setup ; fatigue ; textile-reinforced mortar ; foam concrete (FC) ; FRCM ; fire ; stochastic cracking model ; model ; retrofitting ; toughness ; bending tests ; normal weight/lightweight aggregates ; layered finite elements ; carbon-reinforced concrete ; fiber ; tension ; ACK model ; impact loading ; sandwich elements ; durability ; textile ; creep ; fiber-reinforced concrete ; digital image correlation (DIC) ; moisture ; size effect ; textile reinforcement ; bending ; CRC ; elevated temperatures ; mixture rules ; fibre ; carbon reinforced concrete ; cathodic corrosion protection ; glass fabric ; strengthening ; design provisions ; high performance concrete ; wind loading ; textile reinforced mortar ; masonry ; textile-reinforced concrete ; strain-hardening cement-based composites ; cementitious composites ; design ; carbon textile ; textile reinforced concrete ; textile coating ; thin-walled shells ; reactive powder concrete (RPC) ; shear ; short-fiber reinforcement ; epoxy impregnation ; finite element analysis (FEA) ; bond ; high temperature ; textile reinforced concrete (TRC) ; finite element model ; uniaxial tensile tests ; structural insulating sandwich panel ; shear span ; crack spacing ; hybrid reinforcement ; four-point bending tests ; real scale bending experiments ; single-yarn pullout ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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  • 85
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    Frontiers Media SA
    Publication Date: 2023-12-21
    Description: In the highly competitive world of biomedical science, often the rush to publish and to be recognized as "first" with a new discovery, concept or method, is lost in the hurly-burly of the moment, as "the maddening crowd" moves on to the next "new thing". One of the great things about immunology today is that it has only become mature as a science within the last half-century, and especially within the past 35 years as a consequence of the revolution of molecular immunology, which has taken place only since 1980. Consequently, most of those who have contributed to our new understanding of how the immune system functions are still alive and well, and still contributing. Thus, "A Living History of Immunology" collates many stories from the investigators who actually performed the experiments that have established the frontiers of immunology. Accordingly, this volume combats "revisionist science", by those who want to alter history by telling the stories a different way than actually happened. In this regard, one of the good things about science vs. other disciplines is that we have the written record of what was done, when it was done and by whom. Even so, we do not have the complete story or narrative of how and why experiments were done, and what made the differences that led to success. This volume captures and chronicles some of these stories from the past fifty years in immunology.
    Keywords: R5-920 ; RC581-607 ; cytotoxic T lymphocytes (CTL) ; antibody ; Interleukins ; immunology history ; B cells ; Macrophages ; T cells ; Antibody Forming Cells (AFC) ; Thymus ; T cell receptor (TCR) ; bic Book Industry Communication::M Medicine
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  • 86
    Publication Date: 2023-12-21
    Description: While HIV/AIDS is a global public heath challenge, its impact is arguably greatest in the Sub-Saharan Africa (SSA), where new infections account for approximately 66% of the total number of HIV-positive persons globally. In SSA, medical, social, and economic resources are limited, thus necessitating innovative approaches to disease prevention. One of the mechanisms of prevention that is most promising occurs through HIV disclosure to family members (e.g., adult sexual partners) generally, and to children in particular. Our emphasis in this eBook is on HIV disclosure to children because it has multiple benefits, including improved adherence to antiretroviral medication treatment and understanding at an early age of the impact of sexual activity on the spread of HIV. While there is a noticeable gap in research on HIV disclosure to younger children, some of the general reasons for non-disclosure include concerns about fear of adult partners leaving relationships, and that children are too young to comprehend the severity of the situation and may tell others outside the family. Thus, it is critical to better understand how the HIV disclosure process happens (or does not happen) within HIV-affected families, as well as the best practices on how to disclose. In this eBook, we present a combination of empirical research studies and critical literature reviews that investigate the reasons for and for not disclosing HIV status within HIV-affected families and provide evidence-based practices that could be adopted by healthcare professionals to help HIV-positive parents facilitate disclosure activities within these families. This information can also be used by researchers, practitioners, and stakeholders who are in a position to influence policies on effective HIV disclosure practices, guidelines, and programs.
    Keywords: R5-920 ; RA1-1270 ; HIVAIDS ; Resource-poor setting ; HIV disclosure ; Parental HIV status disclosure ; Sub-Saharan Africa (SSA) ; Child HIV status disclosure ; HIV disclosure process ; bic Book Industry Communication::M Medicine
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  • 87
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-02-01
    Description: The trend of digitalization is an omnipresent phenomenon nowadays – in social life and in the dental community. Advancement in digital technology has fostered research into new dental materials for the use of these workflows, particularly in the field of prosthodontics and oral implantology.CAD/CAM-technology has been the game changer for the production of tooth-borne and implant-supported (monolithic) reconstructions: from optical scanning, to on-screen designing, and rapid prototyping using milling or 3D-printing. In this context, the continuous development and speedy progress in digital workflows and dental materials ensure new opportunities in dentistry.The objective of this Special Issue is to provide an update on the current knowledge with state-of-the-art theory and practical information on digital workflows to determine the uptake of technological innovations in dental materials science. In addition, emphasis is placed on identifying future research needs to manage the continuous increase in digitalization in combination with dental materials and to accomplish their clinical translation.This Special Issue welcomes all types of studies and reviews considering the perspectives of the various stakeholders with regard to digital dentistry and dental materials.
    Keywords: Dentistry ; Prosthodontics ; Implant ; dentistry ; Digital ; technology ; Dental ; materials ; Rapid ; prototyping ; CAD/CAM ; Optical ; scanning ; 3D ; printing ; Translational ; research ; bic Book Industry Communication::M Medicine
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  • 88
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: This Special Edition of Energies on “Energy Storage and Management for Electric Vehicles” draws together a collection of research papers that critically evaluates key areas of innovation and novelty when designing and managing the high-voltage battery system within an electrified powertrain. The addressed topics include design optimisation, mathematical modelling, control engineering, thermal management, and component sizing.
    Keywords: TA1-2040 ; T1-995 ; battery charging ; lithium ion battery ; adaptive forgetting factor ; operating expenses ; cell sorting ; linear programming ; Simulink ; equivalent circuit model ; genetic algorithm ; multi-parameters sorting ; hybrid power system ; electric vehicle ; energy storage ageing and degradation ; parameter estimation ; Simscape ; supercapacitors ; state-of-health (SOH) ; battery energy storage system ; ECE15 ; efficiency ; residential battery storage ; timetable optimization ; self-discharge ; dynamic programming approach ; state of charge estimation ; regenerative energy ; fuel cell ; energy storage system ; nonlinear battery model ; charging scheme ; Li-Sulfur batteries ; Matlab ; dynamic flow rate optimization ; rule-based optimal strategy ; second-life energy storage applications ; Identification ; hybrid vehicle ; recursive least square ; thermal modelling ; zinc–nickel single-flow battery ; Luenberger observer ; HPPC ; vehicle-to-building ; ?-constraint method ; lithium-ion battery ; life cycle assessment ; parameter identification ; Lipschitz nonlinear system ; lithium titanate oxide batteries ; batteries ; battery degradation ; improved artificial bee colony ; optimal control ; thermal behaviour ; supercapacitor models ; battery cycle-life extension ; cycle-life ; self-organizing maps clustering ; principal component analysis ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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  • 89
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Laser welding is a high-energy process used in a wide range of advanced materials to obtain micro- to macro-sized joints in both similar and dissimilar combinations. Moreover, this technique is widely used in several industries, such as automotive, aerospace, and medical industries, as well as in electrical devices. Although laser welding has been used for several decades, significant and exciting innovations often arise from both the process and/or advanced materials side.
    Keywords: TA1-2040 ; T1-995 ; n/a ; tensile strength ; microstructure ; aided electric current ; stainless steel ; accuracy ; porosity control ; laser offset welding ; T-joint ; BTi-6431S ; dissimilar metal ; finite element method ; weld pool behavior ; dissimilar welding ; WPP ; laser welds ; HLAW ; fiber laser ; steel S700MC ; conduction regime ; liquid metal ; buy-to-fly ; EBSD phase mapping ; mass transfer ; mechanical properties ; hardness ; MAG ; phase transformation ; prediction ; LKW ; Ti-5Al-5V-5Mo-3Cr ; laser beam ; laser welding-brazing ; DP1000 steel ; Ti–6Al–4V ; titanium ; low alloyed steel ; H-shaped fusion zone ; pulsed Nd:YAG laser beam welding ; spatter ; high-speed imaging ; weld morphology ; high temperature titanium alloy ; Al/steel joints ; hybrid welding ; dissimilar material ; laser beam welding ; intermetallic layer ; WW ; L-joint ; penetration ; laser stake welding ; laser keyhole welding ; trip steel ; finite element analysis ; laser welding ; magnesium alloy thin sheet ; keyhole ; tensile properties ; dissimilar joining ; IMC layers ; SKM ; fiber laser welding ; aluminium ; dual phase steel ; aluminum alloy T-joint ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
    Language: English
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  • 90
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Agricultural drainage, such as runoffs from farmlands and wineries, are contaminated waters. Their management is monitored by environmental protection authorities who set targets of volume or pollutant reductions. Due to large quantities and seasonal variations, the targets are often not met, and effective management remains a problem in many parts of the world. Natural wetlands are known as the ‘kidneys’ of the earth with unique water purification functions that have long been recognized. Imitating the functions of natural wetlands, constructed wetlands are engineered systems purposely built to treat contaminated waters. They may therefore be called the ‘artificial kidneys’ of the earth. Rural areas often only have low-value lands available for constructed wetlands. Where large quantities of drainage are produced, farmlands are often adjacent to degraded natural wetlands that have reduced ecosystem functions. Controlled discharge and treatment in the wetlands can potentially be part of an integrated solution to multiple environmental problems. This book includes some recent studies on the fate of pollutants removed from agricultural drainage in wetlands, modelling of wetland performance, innovative systems, and the use of non-hazardous agricultural waste in constructed wetlands for wastewater treatment. These studies enhance our understanding of wetland systems, and will help develop wetland technology towards solving the problems associated with agricultural drainage.
    Keywords: TA1-2040 ; TA170-171 ; Agricultural runoff ; wastewater treatment. ; constructed wetland ; pollution control ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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  • 91
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    Unknown
    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: In the last few years, an increasing number of individuals have adopted a gluten free diet (GFD). A significant proportion of that includes patients affected by celiac disease (CD), who have to follow a strict GFD for medical purposes. However, a high number of individuals are currently following a GFD without medical counseling and without a specific diagnosis needing a gluten withdrawal from the diet. This is due to the frequently incorrect information diffused on the Internet and mass media on the topic of GFD. For these reasons, research on the GFD and its clinical use and biological effects is urgently needed.
    Keywords: R5-920 ; RC620-627 ; gluten ; n/a ; mental health ; 33-mer ; gut motility ; gluten re-introduction ; teenagers ; gastric emptying ; islet of Langerhans ; children ; high-fat diet-induced obesity ; affective disorders ; FODMAP intake ; Brazilian CD-QoL ; DQ2.5-glia-?3 epitopes ; place of residence ; zinc ; glutenin ; quality of life (QoL) ; mood disorders ; magnesium ; dietary adherence ; coeliac disease ; food habit ; villous atrophy ; pepsin ; peptides derived from gluten in faeces and urine ; beta cell ; body mass index (BMI) ; oral food challenge ; gliadin ; ?-gliadin ; non-celiac gluten sensitivity ; celiac disease ; wheat ; outcome ; DQ2.5-glia-?1 ; DQ2.5-glia-?2 ; gut microbiota ; type 2 diabetes ; major depressive disorder ; micronutrient ; beta-cell stress ; non-coeliac gluten sensitivity ; screening ; gluten free diet ; gluten-related disorders ; threshold ; diary recommended intake ; wheat species ; non-coeliac wheat sensitivity ; body composition ; serology ; educational level ; mineral ; disease duration ; gastrointestinal symptoms ; gluten-free diet ; NOD mouse ; diagnosis ; osteoporosis ; nutrition ; cholecyst ; wheat allergy ; celiac disease (CD) ; quality of life ; microbiota ; questionnaire ; nutritionists ; structured questionnaires ; Pseudomonas ; intestinal permeability ; Celiac Disease ; economic status ; effectiveness ; type 1 diabetes ; cost ; calcium ; irritable bowel syndrome ; adherence ; non celiac gluten sensitivity ; deficiency ; gluten sensitivity ; iron ; low FODMAP diet ; depression ; clinic ; duodenal biopsies ; fortification ; mucosal recovery ; bic Book Industry Communication::M Medicine
    Language: English
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  • 92
    Publication Date: 2023-12-21
    Description: The recent advances in optical sources and detectors have opened up new opportunities for sensing and imaging techniques which can be successfully used in biomedical and healthcare applications. This book, entitled ‘Optical Methods in Sensing and Imaging for Medical and Biological Applications’, focuses on various aspects of the research and development related to these areas. The book will be a valuable source of information presenting the recent advances in optical methods and novel techniques, as well as their applications in the fields of biomedicine and healthcare, to anyone interested in this subject.
    Keywords: R5-920 ; TA1-2040 ; RM1-950 ; fiber optic sensor ; computational optical sensing and imaging ; imaging spectroscopy ; spectral imaging ; optical coherent tomography ; optical feedback interferometry ; optical tomography ; Raman sensing and imaging ; bic Book Industry Communication::M Medicine
    Language: English
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  • 93
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    Unknown
    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Image analysis is a fundamental task for extracting information from images acquired across a range of different devices. Since reliable quantitative results are requested, image analysis requires highly sophisticated numerical and analytical methods—particularly for applications in medicine, security, and remote sensing, where the results of the processing may consist of vitally important data. The contributions to this book provide a good overview of the most important demands and solutions concerning this research area. In particular, the reader will find image analysis applied for feature extraction, encryption and decryption of data, color segmentation, and in the support new technologies. In all the contributions, entropy plays a pivotal role.
    Keywords: TA1-2040 ; T1-995 ; keyframes ; time-delay ; whale optimization algorithm ; multilevel thresholding ; multi-exposure image fusion ; additive manufacturing ; patch structure decomposition ; ultra-sound images ; 3D scanning ; Arimoto entropy ; contrast enhancement ; spatial filling factor ; depth maps ; image processing ; 3D prints ; differential evolution ; field of experts ; normalized divergence measure ; image privacy ; multiscale top-hat transform ; q-exponential ; texture information entropy ; diffusion ; hybrid algorithm ; Weibull statistics ; adaptive selection ; nonextensive entropy ; computer aided diagnostics ; fatty liver ; random forest ; DNA encoding ; low contrast ; entropy ; Minkowski island ; fuzzy entropy ; free-form deformations ; person re-identification ; chaotic system ; DNA computing ; pavement ; information entropy ; discrete entropy ; Tsallis statistics ; video skimming ; prime-indexed primes ; natural scene statistics (NSS) ; Hénon map ; q-sigmoid ; image entropy ; Shannon entropy ; macrotexture ; Shannon’s entropy ; binary image ; multi-feature fusion ; image analysis ; uncertainty assessment ; non-rigid registration ; hash layer ; Cantor set ; dynamic filtering ; deep neural network ; security analysis ; multiple-image encryption ; Hamming distance ; blind image quality assessment (BIQA) ; q-Gaussian ; remote sensing ; decay trend ; chaotic cryptography ; chaotic strategy ; cross-entropy loss ; random insertion ; metabolic syndrome ; sign languages ; generalized entropies ; relevance feedback ; image retrieval ; two-dimensional chaotic economic map ; cryptanalysis ; infrared images ; 3D Latin cube ; SHA-256 hash value ; gradient distributions ; structural entropy ; discrete cosine transform (DCT) ; chaotic map ; hepatic steatosis ; machine vision ; electromagnetic field optimization ; security ; image segmentation ; quantization loss ; colonoscopy ; video summarization ; permutation ; Kapur’s entropy ; surface quality assessment ; permutation-diffusion ; Ramanujan primes ; Rényi entropies ; chosen-plaintext attack ; image encryption ; dynamic index ; color image segmentation ; ultrasound ; Otsu method ; sigmoid ; reconstruction ; image information entropy ; 3-D digital imaging ; positron emission tomography ; medical imaging ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
    Language: English
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  • 94
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-05-06
    Description: Rare diseases, or orphan diseases, are those that individually affect a small number of patients, but taken together affect over 300 million people worldwide. They are characterized by their etiological, diagnostic and evolutionary complexity, important morbi-mortality, with high levels of disability that entail and hinder the development of a normal vital subject, not only in those who suffer from them, but also their families; therefore, a comprehensive social health approach is necessary to address this problem.About 80% of rare diseases have a genetic origin, mainly monogenic; thus, genetic testing is mandatory for the confirmation of clinical diagnostics and to ensure correct genetic counseling. Next-generation sequencing (NGS) has enabled a revolution in genetic diseases, specially in rare diseases. However, their complexity makes diagnoses difficult even with the advent of NGS.In this Special Issue, we present several examples of the complexity of genetic diagnosis for most of these diseases and the consequences that genetic testing implies for genetic counseling. There are examples of the genetic heterogeneity of hearing loss, some metabolic and lisosomal disorders, ataxia, Prader–Willi syndrome, and three comprehensive reviews on syndromic retinal dystrophies, the complexity of the molecular diagnosis of neuromuscular disorders, and the value of genetic counseling before and after a genetic test.
    Keywords: retina ; inherited retinal diseases ; syndrome ; Turner syndrome ; mosaicism ; ring chromosomes ; growth hormone deficiency ; pituitary microadenoma ; clinical genetics ; early onset ataxia ; dystonia ; neurodevelopment ; network analysis ; bioinformatics ; ataxia ; phenotype ; child ; NGS ; next generation sequencing ; inborn errors of metabolism ; lysosomal disorders ; neuromuscular disease ; genetic testing ; whole exome sequencing ; Prader–Willi syndrome ; imprinting disorder ; recombinant human growth hormone ; insulin-like growth factor 1 ; HMGLD ; HMGCL ; HMG-CoA lyase deficiency ; inherited metabolic diseases ; familial hearing loss ; multiple diagnoses ; non-syndromic hearing loss ; ACTG1 ; MYH9 ; genetic counselling ; rare diseases ; professional recognition ; hearing loss ; genetic diagnosis ; SLC26A4 ; DFNB4 ; Tuvinians ; Altaians ; Southern Siberia ; Russia ; GSDME ; DFNA5 ; single-exon CNV ; n/a ; bic Book Industry Communication::M Medicine
    Language: English
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  • 95
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    Unknown
    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Wood composites have shown very good performance, and substantial service lives when correctly specified for the exposure risks present. Selection of an appropriate product for the job should be accompanied by decisions about the appropriate protection, whether this is by design, by preservative treatment or by wood modification techniques. This Special Issue, Advances in Wood Composites presents recent progress in enhancing and refining the performance and properties of wood composites by chemical and thermal modification and the application of smart nanomaterials, which have made them a particular area of interest for researchers. In addition, it reviews some important aspects in the field of wood composites, with particular focus on their materials, applications, and engineering and scientific advances, including solutions inspired biomimetrically by the structure of wood and wood composites. This Special Issue, with a collection of 13 original contributions, provides selected examples of recent Advances in Wood Composites
    Keywords: TA1-2040 ; T1-995 ; shear strength ; n/a ; buckling ; thermal property ; acetic anhydride ; WPC ; silicon carbide ; coating amount ; composite ; polymer-triticale boards ; wood ; activation volume ; oriented strand lumber (OSL) ; bending strength ; nanowollastonite ; VOCs ; wood-inorganic composites ; thermal modification ; wood plastic composite ; crystallinity ; sol-gel process ; wood adhesive ; straw ; mechanical properties ; bamboo ; plastic ; carbothermal reduction ; formaldehyde emissions ; cellulose ; graphene nano-platelets ; creep behavior ; surface properties ; dimensional stability ; nanocompounds ; UF resin ; tunnel-structured ; ceramic ; color ; water absorption ; high-density polyethylene film ; mechanical property ; aquacultural ; HDPE ; biorefinery lignin ; methyl methacrylate ; structural analysis ; sol–gel process ; polyurethane-acrylate ; mechanical and physical properties ; water-based UV curing coating ; oak (Quercus alba L.) ; dynamic thermodynamic ; stepped isostress method ; thermoplastic polymers ; sustainable adhesives ; finite element analysis ; rapid formaldehyde release ; adhesive penetration ; modulus of elasticity in bending ; Southwell’s method ; hydrophobicity ; Abaqus ; sepiolite ; chemical structure ; alder plywood ; wood panels ; particleboard properties ; chemical modification ; thickness swelling ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
    Language: English
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  • 96
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    Unknown
    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-20
    Description: This book presents a collection of papers revealing the impact of advanced computation and instrumentation on healthcare. It highlights the increasing global trend driving innovation for a new era of multifunctional technologies for personalized digital healthcare. Moreover, it highlights that contemporary research on healthcare is performed on a multidisciplinary basis comprising computational engineering, biomedicine, biomedical engineering, electronic engineering, and automation engineering, among other areas.
    Keywords: eHealth ; mHealth ; telemedicine ; telehealth ; social sciences ; bibliometrics ; telediagnostic ; project management ; funding ; IT infrastructure ; cross-border multiprofessional team ; European Union ; Interreg ; reporting ; quality control ; resident ; diagnostic error ; artificial intelligence ; healthcare AI ; deployment and scaling ; medical center ; critical factors ; stakeholders ; health information technology ; information sharing ; hospital costs ; poverty ratio ; concentration ; continuous glucose monitoring ; insulin pump ; continuous subcutaneous insulin infusion ; pediatric diabetes ; biomedical data ; medical imaging ; shared data ; massive databases ; AI-based healthcare solutions ; trueness ; 3D printing ; milling ; interim dental crown ; digital dentistry ; dental device ; data mining ; bio-signal analysis ; bio-signal repository ; execution engine ; bio-signal monitoring ; digital healthcare ; patient-centric ; blockchain ; federated learning ; coronavirus (COVID-19) ; pandemic management ; healthcare transformation ; public health strategies ; stroke detection ; portable head scanner ; low-intensity EM waves ; intrinsically safe ; low carbon footprint ; orthodontic treatment ; clear aligners ; smart application ; AI ; computerized learning ; behavior change techniques ; decision tree algorithm ; digital interventions ; mental health literacy ; audiovisual ; dentistry ; computer-controlled local anesthetic delivery ; ultrasounds ; chemomechanical caries removal ; modern technologies ; laser ; ozone ; healthcare ; emergency department ; patient flow ; simulation modeling ; agent-based modeling ; pandemic decision support ; additive manufacturing ; patient-centric dosage form ; bic Book Industry Communication::M Medicine
    Language: English
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  • 97
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    Unknown
    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: Supporting initiation, development and resolution of appropriate immune responses is key to survival. Many nutrients and dietary components have been purported to have a role in supporting optimal immune function. This is vital throughout the life course, from the development and programming of the immune system in early life, to supporting immunity and reducing chronic inflammation in older people. In this special issue of Nutrients, we examine the evidence for the role of diet and dietary components in promoting protective immunity.
    Keywords: R5-920 ; RC581-607 ; immunonutrition ; supplementation ; superoxide dismutase (SOD) ; fermented milk ; selenocysteine ; dendritic cells ; lipoxygenase (LOX) ; chronic inflammatory conditions ; formulation ; immune system ; cytokines ; skeletal muscle ; zinc ; non-digestible carbohydrates ; Toll-like receptor ; carbohydrates ; fiber ; lymphocytes ; antibody ; infants ; liver ; macrophage ; inflammatory process ; probiotic ; plant ; older people ; gut barrier ; infection ; amino acids ; gut ; T helper 1 (Th1) ; immunity ; T cells ; bioactive peptide ; inhibitor of kappa kinase (IKK) ; inflammation ; adhesion molecules ; leukocytes ; human milk oligosaccharides ; vitamin D ; food structure ; vitamin E ; mitogen-activated protein Kinase (MAPK) ; gut microbiota ; weaning ; homeostasis ; intestinal immune system ; extra-cellular signal regulated kinases (ERK) ; cyclooxygenase (COX) ; oxidative stress ; life course ; polyphenols ; oligosaccharides ; micronutrients ; Th17 ; obesity ; tolerance ; arachidonic acid ; growth factors ; anti-inflammation ; age-related immunity ; prebiotic ; biomarker ; microbiome ; functional foods ; immunosenescence ; nutrition ; molecular mechanisms ; metabolism ; macronutrients ; toll-like receptor 4 ; sepsis ; nutrition guidelines ; microbiota ; immunomodulation ; inflammatory markers ; elderly ; Th1/Th17 response ; adults ; reactive oxygen species (ROS) ; anorexia nervosa ; macrophages ; autoimmune diseases ; fatty acids ; T cell ; Treg ; breast milk ; nitric oxide synthase (NOS) ; chemokines ; anti-tumorigenic ; metabolites ; deficiency ; protein hydrolysate ; nuclear factor kappa-light-chain-enhancer of activated B cells (NF-?B) ; cancer ; bic Book Industry Communication::M Medicine
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  • 98
    Publication Date: 2023-12-21
    Description: During the recent few decades, global economic growth has been driven largely by developing world economies. The ones with the most intensive pace of development were marked as “emerging“ markets led by so called BRICS and N-11 countries. Such changes inevitably reflected the global health arena. A number of issues previously limited to established high-income economies became popularly discussed topics on the agendas of public health policy makers across these regions. Major challenges remain population aging, rising incidence of prosperity diseases, lack of universal insurance coverage and particularly provision of just and equitable access to medical care among the poor both in urban and rural communities. A significant part of the difficulties faced by these societies are attributed to inefficient resource allocation strategies in health care and unsatisfactory funding strategies. This Research Topic was created in order to address the core challenges of medical care financing and its affordability across the emerging global markets. Contributions of both undergoing or finished original research as well as review style papers are welcomed. All submitted manuscripts should deal with issues relevant to health care economics and policy in recognized global emerging markets. Outside the aforementioned key markets (BRICS- Brazil, Russia, India, China, South Africa; Next 11- Bangladesh, Egypt, Indonesia, Iran, South Korea, Mexico, Nigeria, Pakistan, the Philippines, Turkey and Vietnam) submissions referring to any of the dynamically developing Asian, Latin America, Eastern Europe or MENA countries are encouraged. In addition to a variety of health-economic evaluations and health policy analysis, methodological and resource use studies are within the Topic scope. Health policy considerations should be primarily focused on financing mechanisms and affordability of health care although other surrounding issues such as health insurance, reimbursement and cost-containment strategies will be considered.
    Keywords: R5-920 ; RA1-1270 ; Health Economics ; BRICS ; Hospitals ; cost ; Europe ; Emerging markets ; medical care ; Affordability ; Health financing ; Inequality ; bic Book Industry Communication::M Medicine
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  • 99
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    Frontiers Media SA
    Publication Date: 2023-12-21
    Description: There is increased world-wide concern about the impact of multiple chronic conditions, especially among the rapidly aging population. Simultaneously, over the past decade there has been an emergence of state-wide and national initiatives to reduce the burden of chronic conditions that draw upon the translation of evidence-based programs (EPB) into community practice. Yet, little has been written about the national and international implementation, dissemination, and sustainability of such programs. This Research Topic features articles about EBPs for older adults, including a range of articles that focus on the infrastructure needed to widely disseminate EBP as well as individual participant impacts on physical, mental, and social aspects of health and well-being. Using a pragmatic research perspective, this Research Topic will advance knowledge that aims to enhance practice, inform policy and build systems of support and delivery in regard to the reach, effectiveness, adoption, implementation, and maintenance of evidence-based interventions for older adults. The focus is on knowledge transfer rather than knowledge generation but with a dual emphasis on the dissemination and sustainability of EBP that have been tested and shown effective as well as the adaptation of practice-based interventions into evidence-based programs. This Research Topic draws upon grand-scale efforts to deliver these programs, and include both U.S. as well as international examples. Commentaries discuss processes in the development and measurement of EBP and reflect perspectives from program developers and major national and regional funders of EBP as well as professionals and practitioners in the field. The full-length articles focus on four major programmatic areas: (1) chronic disease self-management programs; (2) fall prevention programs; (3) general wellness and physical activity programs; and (4) mental health programs. Additionally, articles are included to discuss cross-cutting issues related to building partnerships and the research infrastructure for the implementation, evaluation, and dissemination of evidence-based programming. The intent of this Research Topic is to enhance practice, inform policy, and build systems of support and delivery for EBP. It is written for a diverse audience and contains practical implications and recommendations for introducing, delivering, and sustaining EBP in a multitude of settings.
    Keywords: R5-920 ; RA1-1270 ; evidence based programming ; Fall prevention ; CDSMP ; older adults ; chronic disease self management CDSME programs ; healthy aging ; bic Book Industry Communication::M Medicine
    Language: English
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  • 100
    facet.materialart.
    Unknown
    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Agriculture requires technical solutions for increasing production while lessening environmental impact by reducing the application of agro-chemicals and increasing the use of environmentally friendly management practices. A benefit of this is the reduction of production costs. Sensor technologies produce tools to achieve the abovementioned goals. The explosive technological advances and developments in recent years have enormously facilitated the attainment of these objectives, removing many barriers for their implementation, including the reservations expressed by farmers. Precision agriculture and ‘smart farming’ are emerging areas where sensor-based technologies play an important role. Farmers, researchers, and technical manufacturers are joining their efforts to find efficient solutions, improvements in production, and reductions in costs. This book brings together recent research and developments concerning novel sensors and their applications in agriculture. Sensors in agriculture are based on the requirements of farmers, according to the farming operations that need to be addressed.
    Keywords: TA1-2040 ; T1-995 ; optical sensor ; spectral analysis ; response surface sampling ; sensor evaluation ; electromagnetic induction ; multivariate water quality parameters ; mandarin orange ; crop inspection platform ; SPA-MLR ; object tracking ; feature selection ; simultaneous measurement ; diseases ; genetic algorithms ; processing of sensed data ; electrochemical sensors ; thermal image ; ECa-directed soil sampling ; handheld ; recognition patterns ; salt concentration ; clover-grass ; bovine embedded hardware ; weed control ; soil ; field crops ; vineyard ; connected dominating set ; water depth sensors ; SS-OCT ; wheat ; striped stem-borer ; silage ; geostatistics ; detection ; NIR hyperspectral imaging ; electronic nose ; machine learning ; virtual organizations of agents ; packing density ; data validation and calibration ; dataset ; Wi-SUN ; temperature sensors ; geoinformatics ; gas sensor ; X-ray fluorescence spectroscopy ; vegetable oil ; photograph-grid method ; Vitis vinifera ; WSN distribution algorithms ; laser-induced breakdown spectroscopy ; irrigation ; quality assessment ; energy efficiency ; wireless sensor network (WSN) ; geo-information ; Fusarium ; texture features ; weeds ; discrimination ; big data ; soil moisture sensors ; meat spoilage ; land cover ; stereo imaging ; near infrared sensors ; biological sensing ; compound sensor ; pest management ; moisture ; plant localization ; heavy metal contamination ; artificial neural networks ; spectral pre-processing ; moisture content ; apparent soil electrical conductivity ; data fusion ; semi-arid regions ; smart irrigation ; back propagation model ; wireless sensor network ; energy balance ; light-beam ; fluorescent measurement ; agriculture ; precision agriculture ; deep learning ; spectroscopy ; hulled barely ; dielectric probe ; RPAS ; water supply network ; rice leaves ; mobile app ; gradient boosted machines ; hyperspectral camera ; one-class ; nitrogen ; LiDAR ; total carbon ; chemometrics analysis ; rice ; agricultural land ; on-line vis-NIR measurement ; CARS ; obstacle detection ; stratification ; neural networks ; regression estimator ; Kinect ; proximity sensing ; distributed systems ; pest ; noninvasive detection ; texture feature ; soil mapping ; classification ; soil salinity ; visible and near-infrared reflectance spectroscopy ; germination ; computer vision ; hyperspectral imaging ; diffusion ; dielectric dispersion ; UAS ; random forests ; case studies ; total nitrogen ; thermal imaging ; cameras ; dry matter composition ; near-infrared ; salt tolerance ; deep convolutional neural networks ; soil type classification ; water management ; preprocessing methods ; wireless sensor networks (WSN) ; remote sensing image classification ; precision plant protection ; radar ; spatial variability ; GF-1 satellite ; plant disease ; naked barley ; leaf area index ; CIE-Lab ; change of support ; radiative transfer model ; 3D reconstruction ; plant phenotyping ; vine ; near infrared ; vegetation indices ; remote sensing ; greenhouse ; time-series data ; scattering ; sensor ; crop area ; speckle ; spatial data ; grapevine breeding ; wide field view ; partial least squares-discriminant analysis ; spiking ; area frame sampling ; chromium content ; machine-learning ; RGB-D sensor ; pest scouting ; PLS ; Capsicum annuum ; spatial-temporal model ; drying temperature ; boron tolerance ; ambient intelligence ; laser wavelength ; fuzzy logic ; dynamic weight ; landslide ; management zones ; real-time processing ; event detection ; crop monitoring ; apple shelf-life ; rice field monitoring ; wireless sensor ; birth sensor ; proximal sensor ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
    Language: English
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