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  • pharmacokinetics  (2.054)
  • Lepidoptera
  • stability
  • Springer  (3.756)
  • Wiley-Blackwell  (129)
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  • Taylor & Francis  (1)
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  • 1
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    Implications of the Euro (2021)
    Taylor & Francis
    Details
    Publikationsdatum: 2024-03-29
    Beschreibung: To date, critical analysis of the EMU project has largely been advanced from the centre-right spectrum of British politics. Comparable questions from the centre-left have failed to find a coherent voice. Although, the European fault-line cannot be characterized as a neat Left-Right issue there are noticeable divisions in opinion across British business, the trade union movement and within the Labour Party. Offering a unique insight into this key debate from the ‘centre-left’, eurosceptic view point, this book provides a rigorous analysis of all the salient economic and political issues of concern, such as: * the economics of a single currency * employment and social implications * sovereignty * political determination. The arguments presented in this volume highlight the emergence of a coherent alternative to deepening economic integration as a platform to build a just and equitable society. Contributions are drawn from leading academics, trade union leaders and prominent politicians, both from the Labour Party and the wider progressive Left in British politics. This informative and thought provoking book will be indispensable reading for students and practitioners in economics, politics and international relations, as well as those interested in this highly contentious topic.
    Schlagwort(e): single ; currency ; european ; union ; central ; bank ; exchange ; rate ; growth ; stability ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPQ Central / national / federal government::JPQB Central / national / federal government policies ; thema EDItEUR::K Economics, Finance, Business and Management::KC Economics ; thema EDItEUR::K Economics, Finance, Business and Management::KC Economics::KCB Macroeconomics::KCBM Monetary economics ; thema EDItEUR::K Economics, Finance, Business and Management::KC Economics::KCL International economics ; thema EDItEUR::K Economics, Finance, Business and Management::KJ Business and Management ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPQ Central / national / federal government::JPQB Central / national / federal government policies ; thema EDItEUR::K Economics, Finance, Business and Management::KC Economics ; thema EDItEUR::K Economics, Finance, Business and Management::KC Economics::KCB Macroeconomics::KCBM Monetary economics ; thema EDItEUR::K Economics, Finance, Business and Management::KC Economics::KCL International economics ; thema EDItEUR::K Economics, Finance, Business and Management::KJ Business and Management
    Sprache: Englisch
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    Standort Signatur Erwartet Verfügbarkeit
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    E-BOOK
  • 2
    Digitale Medien
    Digitale Medien
    On the stability of wavelet and Gabor frames (Riesz bases) (1999)
    Springer
    The journal of Fourier analysis and applications 5 (1999), S. 105-125 
    Details
    ISSN: 1531-5851
    Schlagwort(e): 26B05 ; 42B10 ; 42C99 ; frame ; Gabor system ; Riesz basis ; stability ; wavelet
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Mathematik
    Notizen: Abstract If the sequence of functions ϕj, k is a wavelet frame (Riesz basis) or Gabor frame (Riesz basis), we obtain its perturbation system ψj,k which is still a frame (Riesz basis) under very mild conditions. For example, we do not need to know that the support of ϕ or ψ $$(\hat \phi or\hat \psi )$$ is compact as in [14]. We also discuss the stability of irregular sampling problems. In order to arrive at some of our results, we set up a general multivariate version of Littlewood-Paley type inequality which was originally considered by Lemarié and Meyer [17], then by Chui and Shi [9], and Long [16].
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01274192
    Standort Signatur Erwartet Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Human Interindividual Variability in Parameters Related to Health Risks (1999)
    Springer
    Risk analysis 19 (1999), S. 711-726 
    Details
    ISSN: 1539-6924
    Schlagwort(e): variability ; exposure ; susceptibility ; risk assessment ; pharmacokinetics ; pharmacodynamics
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Energietechnik
    Notizen: Abstract This paper reviews existing data on the variability in parameters relevant for health risk analyses. We cover both exposure-related parameters and parameters related to individual susceptibility to toxicity. The toxicity/susceptibility data base under construction is part of a longer term research effort to lay the groundwork for quantitative distributional analyses of non-cancer toxic risks. These data are broken down into a variety of parameter types that encompass different portions of the pathway from external exposure to the production of biological responses. The discrete steps in this pathway, as we now conceive them, are: •Contact Rate (Breathing rates per body weight; fish consumption per body weight) •Uptake or Absorption as a Fraction of Intake or Contact Rate •General Systemic Availability Net of First Pass Elimination and Dilution via Distribution Volume (e.g., initial blood concentration per mg/kg of uptake) •Systemic Elimination (half life or clearance) •Active Site Concentration per Systemic Blood or Plasma Concentration •Physiological Parameter Change per Active Site Concentration (expressed as the dose required to make a given percentage change in different people, or the dose required to achieve some proportion of an individual's maximum response to the drug or toxicant) •Functional Reserve Capacity–Change in Baseline Physiological Parameter Needed to Produce a Biological Response or Pass a Criterion of Abnormal Function Comparison of the amounts of variability observed for the different parameter types suggests that appreciable variability is associated with the final step in the process–differences among people in “functional reserve capacity.” This has the implication that relevant information for estimating effective toxic susceptibility distributions may be gleaned by direct studies of the population distributions of key physiological parameters in people that are not exposed to the environmental and occupational toxicants that are thought to perturb those parameters. This is illustrated with some recent observations of the population distributions of Low Density Lipoprotein Cholesterol from the second and third National Health and Nutrition Examination Surveys.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1007045922532
    Standort Signatur Erwartet Verfügbarkeit
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  • 4
    Digitale Medien
    Digitale Medien
    Evaluation of the Uncertainty in an Oral Reference Dose for Methylmercury Due to Interindividual Variability in Pharmacokinetics (1999)
    Springer
    Risk analysis 19 (1999), S. 547-558 
    Details
    ISSN: 1539-6924
    Schlagwort(e): MeHg ; pharmacokinetics ; PBPK model ; variability ; risk assessment
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Energietechnik
    Notizen: Abstract An analysis of the uncertainty in guidelines for the ingestion of methylmercury (MeHg) due to human pharmacokinetic variability was conducted using a physiologically based pharmacokinetic (PBPK) model that describes MeHg kinetics in the pregnant human and fetus. Two alternative derivations of an ingestion guideline for MeHg were considered: the U.S. Environmental Protection Agency reference dose (RfD) of 0.1 μg/kg/day derived from studies of an Iraqi grain poisoning episode, and the Agency for Toxic Substances and Disease Registry chronic oral minimal risk level (MRL) of 0.5 μg/kg/day based on studies of a fish-eating population in the Seychelles Islands. Calculation of an ingestion guideline for MeHg from either of these epidemiological studies requires calculation of a dose conversion factor (DCF) relating a hair mercury concentration to a chronic MeHg ingestion rate. To evaluate the uncertainty in this DCF across the population of U.S. women of child-bearing age, Monte Carlo analyses were performed in which distributions for each of the parameters in the PBPK model were randomly sampled 1000 times. The 1st and 5th percentiles of the resulting distribution of DCFs were a factor of 1.8 and 1.5 below the median, respectively. This estimate of variability is consistent with, but somewhat less than, previous analyses performed with empirical, one-compartment pharmacokinetic models. The use of a consistent factor in both guidelines of 1.5 for pharmacokinetic variability in the DCF, and keeping all other aspects of the derivations unchanged, would result in an RfD of 0.2 μg/kg/day and an MRL of 0.3 μg/kg/day.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1007017116171
    Standort Signatur Erwartet Verfügbarkeit
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  • 5
    Digitale Medien
    Digitale Medien
    Stabilization of smoothness priors time-varying autoregressive models (2000)
    Springer
    Circuits, systems and signal processing 19 (2000), S. 423-435 
    Details
    ISSN: 1531-5878
    Schlagwort(e): Time-varying autoregressive models ; stability ; smoothness priors ; Tihkonov regularization ; constrained optimization
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract The stability of time-varying autoregressive (AR) models is an important issue in such applications as time-varying spectrum estimation and electroencephalography simulation and estimation. In some cases, such as time-varying spectrum estimation, the models that exhibit roots near unit moduli are difficult to use. Thus a tighter stability condition such as stability with a positive margin is needed. A time-varying AR model is stable with a positive margin if the moduli of the roots of the time-varying characteristic polynomial are somewhat less than unity for every time instant. Recently, a new method for the estimation of the time-varying AR models was introduced. This method is based on the interpretation of the underdetermined time-varying prediction equations as an ill-posed inverse problem that is solved by Tikhonov regularization. The method is referred to as the deterministic regression smoothness priors (DRSP) scheme. In this paper, a stabilization method in which the DRSP scheme is augmented with nonlinear stability constrainst is proposed. The problem is formulated so that stability with a positive margin can also be achieved. The problem is solved iteratively with an exterior point algorithm. The performance of the algorithm is studied with a simulation. It is shown that the proposed approach is well suited to stable modeling of signals containing narrowband transitions.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01196156
    Standort Signatur Erwartet Verfügbarkeit
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  • 6
    Digitale Medien
    Digitale Medien
    Stability of constant coefficient linear singular systems with delay (2000)
    Springer
    Circuits, systems and signal processing 19 (2000), S. 13-25 
    Details
    ISSN: 1531-5878
    Schlagwort(e): Singular systems ; delay ; consistency condition ; stability ; instability
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract In this paper, the general class of singular systems with delay and linear constant coefficient singular systems with delay are discussed. First, several definitions of stability are presented for singular systems with delay, and general sufficient stability conditions and instability conditions are obtained. Second, stability and instability are analyzed for linear constant coefficient singular systems with delay.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01229989
    Standort Signatur Erwartet Verfügbarkeit
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  • 7
    Digitale Medien
    Digitale Medien
    On the stability of multistep formulas for Volterra integral equations of the second kind (1980)
    Springer
    Computing 24 (1980), S. 341-347 
    Details
    ISSN: 1436-5057
    Schlagwort(e): Numerical analysis ; Volterra integral equations of the second kind ; stability
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Informatik
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung Ziel dieser Arbeit ist es, die Stabilitätseigenschaften einer Klasse Volterrascher Integralgleichungen zweiter Art zu untersuchen. Unsere Behandlung ist der üblichen Stabilitätsanalyse ähnlich, in der die Kernfunktionen zu einer im voraus beschränkten Klasse von Testfunktionen gehören. Wir haben die Klasse der “endlich zerlegbaren” Kerne betrachtet. Stabilitätsbedingungen werden abgeleitet und verglichen mit den Bedingungen für die einfache Testgleichung. Es zeigt sich, daß die neuen Kriteria einschränkender sind als die konventionellen Bedingungen. Der praktische Wert wird getestet durch numerische Experimente mit der Trapezregel.
    Notizen: Abstract The purpose of this paper is to analyse the stability properties of a class of multistep methods for second kind Volterra integral equations. Our approach follows the usual analysis in which the kernel function is a priori restricted to a special class of test functions. We consider the class of finitely decomposable kernels. Stability conditions will be derived and compared with those obtained with the simple test equation. It turns out that the new criteria are more severe than the conventional conditions. The practical value is tested by numerical experiments with the trapezoidal rule.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02237819
    Standort Signatur Erwartet Verfügbarkeit
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  • 8
    Digitale Medien
    Digitale Medien
    Box schemes on quadrilateral meshes (1993)
    Springer
    Computing 51 (1993), S. 271-292 
    Details
    ISSN: 1436-5057
    Schlagwort(e): 65N15 ; 65N99 ; 35A40 ; Box method ; boundary value problem ; finite volume method ; variational formulation ; stability ; error bounds
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Informatik
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung Box-Methoden (Finite-Volumen-Methoden) sind verbreitete Verfahren zur Lösung physikalischer Erhaltungsgleichungen, insbesondere in der Strömungsmechanik. In dieser Arbeit werden zwei Methoden für elliptische Differentialgleichungen untersucht, die Diagonal-Boxen und die Schwerpunkt-Boxen. Da die Box-Methoden im Sinne von Petrov-Galerkin-Verfahren interpretiert werden können, erhält man vergleichbar zur Finiten-Element-Methode eine variationsrechnerische Stabilitäts- und Fehleranalyse. Damit werdenO(h)- undO(h 2)-Fehlerabschätzungen hergeleitet. Lokale Eigenwertprobleme führen zu Stabilitätsaussagen. Allerdings ergibt sich eine Abhängigkeit von der Anzahl und Art gestörter Vierecke. Insbesondere die Diagonal-Boxen sind anfällig für lokale Störungen.
    Notizen: Abstract Box schemes (finite volume methods) are widely used in fluiddynamics, especially for the solution of conservation laws. In this paper two box-schemes for elliptic equations are analysed with respect to quadrilateral meshes. Using a variational formulation, we gain stability theorems for two different box methods, namely the so-called diagonal boxes and the centre boxes. The analysis is based on an elementwise eigenvalue problem. Stability can only be guaranteed under additional assumptions on the geometry of the quadrilaterals. For the diagonal boxes unsuitable elements can lead to global instabilities. The centre boxes are more robust and differ not so much from the finite element approach. In the stable case, convergence results up to second order are proved with well-known techniques.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02238536
    Standort Signatur Erwartet Verfügbarkeit
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  • 9
    Digitale Medien
    Digitale Medien
    A note on stability investigations for Rosenbrock-type methods for quasilinear-implicit differential equations (1996)
    Springer
    Computing 56 (1996), S. 47-59 
    Details
    ISSN: 1436-5057
    Schlagwort(e): 65 L 05 ; Rosenbrock-type methods ; quasilinear-implicit differential equations ; stability
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Informatik
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung Bei der Lösung quasilinear-impliziter ODEs mittels Rosenbrock-Typ-Methoden können trotz guter Stabilitätseigenschaften (A- bzw. L-Stabilität) des Grundverfahrens Stabilitätsprobleme auftreten. Diese Schwierigkeiten sind auf Ungenauigkeiten bei der Berechnung künstlich eingeführter Komponenten (Überführung in DAEs) zurückzuführen. Die Arbeit untersucht die Ursachen für diese Effekte und zeigt Möglichkeiten, diese zu überwinden.
    Notizen: Abstract The solution of quasilinear-implicit ODEs using Rosenbrock type methods may suffer from stability problems despite stability properties such as A-stability or L-stability, respectively. These problems are caused by inexact computation of artificial introduced components (transformation to DAE system). The paper investigates the source of the numerical difficulties and shows modifications to overcome them.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02238291
    Standort Signatur Erwartet Verfügbarkeit
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  • 10
    Digitale Medien
    Digitale Medien
    Das Rückstandsverhalten von Chloramphenicol nach intramuskulärer Applikation beim Schwein (1985)
    Springer
    European journal of nutrition 24 (1985), S. 113-119 
    Details
    ISSN: 1436-6215
    Schlagwort(e): Chloramphenicol ; pharmacokinetics ; residue ; pig
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Land- und Forstwirtschaft, Gartenbau, Fischereiwirtschaft, Hauswirtschaft , Medizin
    Beschreibung / Inhaltsverzeichnis: Summary Residues of Chloramphenicol (CAP) were examined in 24 pigs after intramuscular injection of 30 mg CAP/kg body weight. Two pigs were slaughtered after 3, 6, 12,18, 24, 36 hours, 2, 3, 6, 10, 21 and 30 days, respectively. CAP-concentrations were determined in muscle, blood, urine, liver, kidney, bile, and fat. Methods used were gas-liquid chromatography and radioimmunoassay. Detection limits reached were 1−5 ppb. The concentration-time curves obtained reflected a long elimination phase and allowed only calculation of this half-life. Elimination half-life was estimated to be for muscle, blood and urine 160–170 hours, for kidney 310 and for bile 250 hours. Significant correlations were found to exist between CAP-concentrations in plasma and muscle. It appears that blood would be a good body fluid for monitoring CAP-residues in tissue.
    Notizen: Zusammenfassung Zur Untersuchung des Rückstandsverhaltens von Chloramphenicol (CAP) wurden 24 Mastschweine, 24–28 Wochen alt, intramuskulär mit 30 mg CAP/kg Körpergewicht behandelt und je 2 Tiere nach 3, 6, 12, 18, 24, 36 Stunden, 2, 3, 6, 10, 21 und 30 Tagen geschlachtet. Die CAP-Gehalte in Muskulatur, Blut, Urin, Leber, Niere, Galle und Fett wurden gaschromatographisch und radioimmunologisch bestimmt. Die Nachweisgrenze beider Methoden liegt in Abhängigkeit von der Matrix zwischen 1 und 5 ppb. Die erhaltenen Kinetiken weisen eine terminale Elimination auf, deren Halbwertszeiten für Muskulatur, Blut und Urin ca. 160–170 Stunden, für Niere 310 Stunden und für Galle 250 Stunden betragen. Die CAP-Konzentration in Muskulatur und Blut weisen eine signifikante, lineare Korrelation auf. Blutuntersuchungen könnten deshalb als Screening-Methode bei umfangreichen Rückstandskontrollen eingesetzt werden.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02020458
    Standort Signatur Erwartet Verfügbarkeit
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