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  • pharmacokinetics  (2,066)
  • growth
  • Springer  (2,702)
  • MDPI - Multidisciplinary Digital Publishing Institute  (103)
  • Texas Game and Fish Commission Marine Laboratory  (3)
  • American Chemical Society (ACS)
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  • 1
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    Transmucosal Absorption Enhancers in the Drug Delivery Field (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-12-21
    Description: Development of strategies to assist the movement of poorly permeable molecules across biological barriers has long been the goal of drug delivery science. In the last three decades, there has been an exponential increase in advanced drug delivery systems that aim to address this issue. However, most proprietary delivery technologies that have progressed to clinical development are based on permeation enhancers (PEs) that have a history of safe use in man. This Special Issue entitled “Transmucosal Absorption Enhancers in the Drug Delivery Field” aims to present the current state-of-the-art in the application of PEs to improve drug absorption. Emphasis is placed on identification of novel permeation enhancers, mechanisms of barrier alteration, physicochemical properties of PEs that contribute to optimal enhancement action, new delivery models to assess PEs, studies assessing safety of PEs, approaches to assist translation of PEs into effective oral, nasal, ocular and vaginal dosage forms and combining PEs with other delivery strategies.
    Keywords: R5-920 ; RM1-950 ; chitosan ; intestinal epithelial cells ; ocular delivery ; amphiphilic polymers ; cornea ; tight junction modulator ; cyclodextrin ; permeability ; gemini surfactant ; transferrin ; compound 48/80 ; epithelial permeability ; cervicovaginal tumors ; nanoparticles ; confocal laser scanning microscopy ; safety ; formulation ; salcaprozate sodium ; intestinal absorption ; FITC-dextran ; curcumin ; block copolymers ; nasal vaccination ; whole leaf ; brush border ; ocular drug delivery ; vaccine adjuvant ; nanoparticle ; nasal delivery ; efflux ; permeation enhancers ; absorption enhancers ; nose to brain delivery ; small intestine ; epithelium ; CNS disorders ; absorption modifying excipients ; insulin ; absorption enhancer ; gel ; intestinal delivery ; thermogel system ; Caco-2 ; biocompatibility studies ; absorption enhancement ; man ; PN159 ; poorly absorbed drug ; tryptophan ; tight junction ; oral macromolecule delivery ; penetration enhancer ; intestinal permeation enhancers ; nanocrystals ; simvastatin ; nanomedicine ; enterocyte ; N-dodecyl-?-D-maltoside (DDM) ; cell-penetrating peptide ; quaternization ; KLAL ; nasal ; nasal permeability ; transmucosal drug delivery ; Caco-2 cells ; mast cell activator ; penetration enhancers ; drug delivery ; nose-to-brain ; bioenhancer ; polymeric micelles ; mucoadhesion ; cell-penetrating peptide (CPP) ; simulated intestinal fluid ; vaginal delivery ; nasal formulation ; pharmacokinetic interaction ; sodium caprate ; clinical trial ; transmucosal permeation ; drug absorption enhancer ; sugar-based surfactants ; nanocapsules ; imatinib ; teriparatide ; osteoporosis ; hydrophobization ; F-actin ; combined microsphere ; transepithelial electrical resistance ; oral delivery ; ocular conditions ; metabolism ; antimicrobial peptide ; permeation enhancer ; drug administration ; antiepileptic drug ; amino acid ; in vivo studies ; sodium cholate (NaC) ; epithelial transport ; preclinical ; nose to brain transport ; pharmacokinetics ; chitosan derivatives ; ophthalmology ; tight junctions ; sheep ; cationic functionalization ; GLP-1 ; pulmonary ; and liposome ; cytochrome P450 ; claudin ; P-glycoprotein ; in situ hydrogel ; mucoadhesiveness ; PTH 1-34 ; Aloe vera ; oral peptides ; bic Book Industry Communication::M Medicine
    Language: English
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  • 2
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    Animal Welfare Assessment (2022)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2022-11-17
    Description: This Special Issue provides a collection of recent research and reviews that investigate many areas of welfare assessment, such as novel approaches and technologies used to evaluate the welfare of farmed, captive, or wild animals. Research in this Special Issue includes welfare assessment related to pilot whales, finishing pigs, commercial turkey flocks, and dairy goats; the use of sensors or wearable technologies, such as heart rate monitors to assess sleep in dairy cows, ear tag sensors, and machine learning to assess commercial pig behaviour; non-invasive measures, such as video monitoring of behaviour, computer vision to analyse video footage of red foxes, remote camera traps of free-roaming wild horses, infrared thermography of effort and sport recovery in sport horses; telomere length and regulatory genes as novel biomarkers of stress in broiler chickens; the effect of environment on growth physiology and behaviour of laboratory rare minnows and housing system on anxiety, stress, fear, and immune function of laying hens; and discussions of natural behaviour in farm animal welfare and maintaining health, welfare, and productivity of commercial pig herds.
    Keywords: bioethics ; domestication ; genetic selection ; animal behavior ; animal welfare ; eye caruncle temperature ; Spanish Sport Horse ; performance test ; genetic lines ; heritability ; infrared thermography ; pigs ; welfare ; health ; herd management ; monitoring technologies ; animal husbandry ; welfare assessment ; wellbeing ; goat ; caprine ; dairy ; dairy cows ; heart rate ; sleep ; heart rate variability ; polysomnography ; animal-based welfare indicators ; camera traps ; wild horses ; precision swine farming ; ear tag pig sensor ; behavioral monitoring ; machine intelligence ; technology adoption ; broiler ; corticosterone ; performance ; telomeres ; telomere regulators ; stress biomarkers ; horse ; equine ; lying ; time budget ; locomotion ; geriatric ; orthopedic ; recumbency ; mixed commercial turkey flocks ; on-farm assessment ; YOLOv4 ; computer vision ; animal monitoring ; animal activity ; body posture ; rare minnow ; environmental enrichment ; growth ; physiology ; anxiety-like behavior ; enrichment ; hospitalization requirement ; lameness ; lesions ; tail biting ; attention bias ; conventional cage ; environmental complexity ; feather corticosterone ; IgA ; laying hen ; animal welfare assessment ; behaviour ; human intervention ; marine mammal ; cetacean ; management ; stranding ; wildlife ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSA Life sciences: general issues::PSAK Genetics (non-medical)
    Language: English
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  • 3
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    Welfare of Cultured and Experimental Fishes (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2024-04-05
    Description: Welfare is a multidimensional concept that can be described as the state of an animal as it copes with the environment. Captive environments can impact farmed animals at different levels, especially fishes, considering their highly complex sensory world. Understanding the ethology of a species is therefore essential to address fish welfare, and the interpretation of behavioral responses in specific rearing contexts (aquaculture or experimental contexts) demands knowledge of their underlying physiological, developmental, functional, and evolutionary mechanisms. In natural environments, the stress response has evolved to help animals survive challenging conditions. However, animals are adapted to deal with natural stressors, while anthropogenic stimuli may represent stressors that fishes are unable to cope with. Under such circumstances, stress responses may be maladaptive and cause severe damage to the animal. As welfare in captivity is affected in multiple dimensions, multiple possible indicators can be used to assess the welfare state of individuals. In the past, research on welfare has been largely focusing on health indicators and predominantly based on physiological stress. Ethological indicators, however, also integrate the mental perspective of the individual and have been gradually assuming an important role in welfare research: behavioral responses to stressors are an early response to adverse conditions, easily observable, and demonstrative of emotional states. Many behavioral indicators can be used as non-invasive measurements of welfare in practical contexts such as aquaculture and experimentation. Presently, research in fish welfare is growing in importance and interest because of the growing economic importance of fish farming, the comparative biology opportunities that experimental fishes provide, and the increasing public sensitivity to welfare issues.
    Keywords: QH301-705.5 ; SF1-1100 ; Q1-390 ; n/a ; muscle texture ; fractal analysis ; fish welfare ; Danio rerio ; motivation ; histopathology ; elevated phosphate concentrations ; sharks ; welfare ; African catfish (Clarias gariepinus) ; feed efficiency ; fighting ability ; aggressive interaction ; social rank ; boldness ; ethology ; fisheries management ; physiological response ; FishEthoBase ; welfare scores ; welfare criteria ; stress ; pain ; stereotypical behaviour ; Scyliorhinus canicula ; animal behavior ; welfare enhancement ; social communication ; nociception ; negative and positive affect ; aggression ; fertilisation success ; risk analysis ; aquaculture ; hematology ; Amyloodinium ocellatum ; framework ; structural complexity ; territorial ; growth ; positive welfare ; social stress ; age ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
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  • 4
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    Plant Oxidative Stress: Biology, Physiology and Mitigation (2022)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2022-06-21
    Description: This Special Issue, “Plant Oxidative Stress: Biology, Physiology, and Mitigation”, published 11 original research works and 1 review article that discussed the various aspects of ROS Biology, metabolism, and the physiological mechanisms and approaches to mitigating oxidative stress. These types of research studies show further directions for the development of crop plants that are tolerant to abiotic stress in the era of climate change.
    Keywords: heat stress ; grafting ; cucumber ; bitter-melon rootstock ; polyamines ; photosynthesis ; salicylic acid ; chlorophyll fluorescence ; excess boron ; lipid peroxidation ; enzymatic antioxidant ; glutathione ; proline ; stomatal conductance ; arsenic stress ; soybean ; growth ; antioxidant enzymes ; ascorbate–glutathione cycle ; glyoxalase system ; altitudinal variation ; antioxidant activity ; bioactive compounds ; endemic species ; oxidative damage ; sequential application of antioxidants ; salinity ; Cucumis sativus ; photosynthetic efficiency ; antioxidant defense systems ; antioxidants ; cadmium ; oxidative stress ; peptone ; spinach ; alpha-tocopherol ; foliar spray ; okra varieties ; salt ; drought ; plants ; ROS ; genomics ; approaches ; integration ; abiotic stress ; antioxidant defense ; phytohormones ; pulse crop ; water deficit ; AsA-GSH pathway ; methylglyoxal ; micronutrient ; osmoregulation ; reactive oxygen species ; trace elements ; Olea europaea L. ; selenium biofortification ; olive pollen ; cytosolic Ca2+ ; Cucurbita pepo (L.) ; mineral uptake ; nucleic acids ; n/a ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PST Botany & plant sciences
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  • 5
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    Model-Informed Precision Dosing (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-04-05
    Description: Model-informed precision dosing (MIPD) is an advanced quantitative approach focusing on individualized treatment optimization. MIPD integrates mathematical models of drugs and diseases combined with individual patient characteristics (e.g., genotype, anthropometric factors, and organ function). MIPD has been highlighted as a useful tool for drug dosage selection in both the drug development process and clinical practice and it is a rapidly growing discipline that is supported by the main drug regulatory agencies. Despite the potential benefits of this methodology toward personalized medicine, its application is still limited. The Special Issue presented here includes several PKPD and PBPK models focused on improving the current state of art regarding the PK behaviour of different drugs with the aim of improving the efficacy/safety balance of these treatments and their clinical outcome; the Special Issue is intended to be of particular interest for clinical pharmacologists, pharmacometricians, and specific clinicians who routinely use the considered drugs.
    Keywords: model-informed precision dosing (MIPD) ; efficacy PKPD indexes ; pharmacokinetics ; pharmacodynamics ; PKPD modeling and simulation ; dosing algorithms ; nomograms ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::K Economics, finance, business & management::KN Industry & industrial studies::KND Manufacturing industries::KNDP Pharmaceutical industries
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  • 6
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    Blood-Derived Products for Tissue Repair/Regeneration (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-12-21
    Description: This Special Issue on “Blood-Derived Products for Tissue Repair and Regeneration” reveals the evolution and diversity of platelet rich plasma (PRP) technologies, which includes experimental research on novel formulations, the creation of combination therapies, and the exploration of potential modifiers of PRPs, as well as efficacy of PRP therapies in clinical veterinary and human applications. Scientist and clinicians are now starting to develop different treatments based on their reinterpretation of the traditional roles of platelets and plasma, and the current Issue has provided a forum for sharing research and ways of understanding the associated medicinal benefits from different points of view. The research interest in this area has covered different medical disciplines, such as ophthalmology, dentistry, orthopedics, and sports medicine.
    Keywords: R5-920 ; RM1-950 ; n/a ; biomaterial ; redifferentiation ; regenerative medicine ; skeletal muscle regeneration ; furcation defects ; Platelet-Rich Plasma (PRP) ; PRP ; fracture ; fibrin sealant ; periodontal surgery ; bone regeneration ; serum derived from plasma rich in growth factors (s-PRGF) ; cartilage repair ; myofibroblasts ; autologous platelet concentrates ; burns ; satellite cells ; articular cartilage ; stem cell niche ; wound healing ; quantification ; growth factors ; biologics ; platelet rich plasma ; meniscus ; adipose tissue ; Carprofen ; platelet-rich fibrin ; platelets ; hyperacute serum ; bone defects ; serum eye drops ; corneal epithelial defect ; fibrosis ; dog ; myoblasts ; differentiation ; chronic meniscal lesion ; horizontal meniscal tear ; PRGF ; collagen hydrogels ; periodontal defects ; bone grafting material ; composition ; cell therapy ; bone healing ; tissue healing ; trephination ; plasma rich plasma (PRP) ; bone repair ; plasma rich in growth factors ; knee arthrosis ; meniscus tear ; cornea regeneration ; wrist osteoarthritis ; periosteal sheet ; Platelet-Poor Plasma (PPP) ; platelet-rich plasma ; microfat ; bone grafting ; hyaluronic acid (NaHA) ; periodontal regeneration ; meniscus repair ; photobiomodulation therapy ; growth ; myogenesis ; blood derived products ; low-level laser therapy ; bic Book Industry Communication::M Medicine
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  • 7
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    Fungal Architectures (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2024-04-09
    Description: This reprint presents groundbreaking discoveries, practical techniques, and rigorous analyses related to the cultivation, preparation, and exploitation of mycelium composites. The papers cover a wide range of topics, including functional modifications of mycelium with inorganic particles, modifying and assessing the mechanical properties of mycelium composites, strategies for improving the flexural behaviour of composites, beehives from fungal materials, bio-welding and reinforcement of composites, bioreactors for fungal production, co-production of composites by fungi and bacteria, growing large-scale mycelium structures, sound absorption by composites, and the geometrical parameterisation of fungi. This informative compendium of techniques, methods, and insights on growing fungal material appeals to readers from all walks of life, from high school pupils to university professors, from mathematicians, computer scientists, and engineers to chemists, from craft practitioners to industrial producers of fungal materials, and from biologists to architects and artists.
    Keywords: mycelium-based composites ; additive manufacturing ; bio-based materials ; circular construction ; digital fabrication ; mycelium ; bio-composites ; bio-fabrication ; ultrasonic welding ; wood printing ; robotic fabrication ; reinforced composites ; natural fiber reinforced polymers ; NFRP ; growing materials ; rattan ; lightweight structure ; architecture ; structural design ; computational design ; subtractive manufacturing ; circular economy ; compressive structures ; compressive strength ; digital image correlation ; masonry ; growth ; mechanical properties ; materials science ; mycelium-based composite ; biomaterials ; natural composites ; bacterial cellulose ; biocompatibility ; knitted fabric ; material tinkering ; lignocellulosic fibers ; natural fiber reinforcement ; mechanical characteristics ; manufacturing variables ; nanoclay ; fungal fruiting bodies ; parametric design thinking ; plasticity ; linearity ; non-linearity ; biohybrid architecture ; bio fabrication ; living architecture ; beehive ; 3D printing ; mycelium materials ; symbiosis ; multispecies architecture ; healthy materials ; binding capacity ; bio-adhesives ; building biomaterials ; fungal mycelium ; mechanical performance ; acoustic materials ; sound absorption ; fungal architecture ; myceliated material ; living material ; sustainability ; biotechnology ; compression ; bending ; waste upcycling ; mycoremediation ; myco-materials ; myco-fabrication ; sustainable buildings ; sustainable structures ; architectural design ; material ethics ; modular chain bioreactor ; solid-state fermentation ; mycelium production ; Ganoderma lucidum ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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  • 8
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    Seedling Production and Field Performance of Seedlings (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-12-20
    Description: Rapid establishment of seedlings in forest regeneration or afforestation sites after planting is a prerequisite for a successful reforestation. Seedling survival after outplanting can be improved by using high-quality seedling material. Seedling quality consists of several features, such as genetic source, morphological properties, nutritional status, stress resistance, and vitality of the seedlings. Field performance of the seedlings is a complex process which can be affected by many nursery and silvicultural practices. Nursery cultural practices strongly affect seedling quality, which is generally at its highest level during the growth period at the nursery. Afterwards, when the seedlings are transported from the nursery to the planting site (including seedling storage, handling, shipping, and planting practices), the quality of seedlings can only remain the same or decline. To ensure successful regeneration, it is important to produce seedlings that retain their high quality until planting, and to establish them quickly in the forest regeneration site.
    Keywords: Q1-390 ; container parameters ; forest regeneration material ; physiological attributes ; somatic embryogenesis ; Quercus rubra ; antioxidant enzymes ; nursery production ; shortleaf pine ; historical perspective ; maturation ; Appalachia ; bulk density ; Quercus robur L. ; rabbit ; western larch ; Picea abies L. Karst. ; sessile oak ; climate change ; physiological quality ; nursery culture ; Fennoscandia ; pedunculate oak ; elk ; seeds ; survival ; small mammal ; loblolly pine ; Norway spruce ; white oak ; growing media ; germination ; morphological attributes ; embling production ; mechanization ; browse ; contractor ; field performance ; reforestation ; white-tailed deer ; forest biotechnology ; cultural practice ; hybridization ; nutrients ; silviculture ; black locust ; scarification index ; seedling quality ; tree planting machine ; seed size ; herbicide ; artificial regeneration ; restoration ecology ; porosity ; northern red oak ; cryopreservation ; leaf senescence ; tree seedling ; Douglas fir ; Quercus ; growth ; mine reclamation ; forestry ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general
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  • 9
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    Cave Communities: From the Surface Border to the Deep Darkness (2024)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2024-01-08
    Description: From a biological perspective, the subterranean realm is one of the less studied, but at the same time, one of the most promising, theatres for new findings and research. Compared to those on the surface, the ecological conditions occurring in subterranean habitats are relatively simple, and this may be an optimal scenario for understanding the mechanisms allowing the colonization, adaptation, and evolution of species, as well as their interactions within local communities. Diversity in subterranean habitats is often overlooked, and few studies embrace whole communities or try to assess functional relationships between species. This Special Issue reprint comprises papers covering a wide range of aspects related to the distribution, composition, and roles of subterranean communities occurring in different typologies of subterranean habitats.
    Keywords: cave biology ; subterranean habitats ; vertebrates ; invertebrates ; community dynamics ; biospeleology ; hypogean ; conservation ; biodiversity ; troglobite ; troglophile ; trogloxene ; extreme environment ; niche ; epikarst ; classification trees ; Copepoda ; random forests ; Diptera ; Limonia ; Limonia nubeculosa ; Neolimonia ; Trichoceridea ; cave community ; prey ; food resources ; occupancy ; abundance ; Astyanax ; Spelaeomysis ; Troglomexicanus ; Speocirolana ; Toro cave ; Sierra de El Abra ; troglomorphy ; stygobite ; fieldwork ; wild fish ; comparative biology ; behavior ; troglomorphism ; olfactory test ; infrared movies ; amino acids ; chondroitin ; plasticity ; cybernetics ; ecology ; cavefish ; dissolved oxygen ; cave evolution ; Astyanax mexicanus ; Ostracoda ; Yucatán Peninsula ; cenotes ; mitochondrial marker ; geometric morphometrics ; population ecology ; growth ; movements ; São Domingos karst area ; subterranean fishes ; evolution ; origin of troglobites ; Brazil ; subterranean biology ; environmental science ; biogeography ; distribution records ; groundwater ; underwater caves ; cenote ; mysid ; stygobiont ; bioindicator ; accidental cave visitors ; Arachnida ; Araneae ; arid ; levant ; Mediterranean ; species diversity ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSV Zoology & animal sciences
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  • 10
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    Greenhouse Management for Better Vegetable Quality, Higher Nutrient Use Efficiency and Healthier Soil (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-02-02
    Description: Greenhouse cultivation provides an artificially controlled environment for the year-round production of vegetables, and has played an increasingly important role in agriculture production systems in recent decades. Recent works have shown that improving greenhouse conditions can promote the growth of vegetables and enhance the uptake of nutrients, leading to better vegetable quality. Meanwhile, greenhouse conditions not only directly influence soil nutrient cycling processes and properties, but also indirectly affect them by regulating vegetable root growth and plant–soil interactions. This Special Issue features twelve original research articles that deal with the effects of novel greenhouse practices and strategies on the yield and quality of horticulture crops, as well as greenhouse soil properties. Among these publications, three studied the effects of fertilizers, including organic and macro- and micro-nutrient fertilizers, on the growth and nutrient uptake of vegetables. Two articles described the effects of water and nutrient supply using irrigation or hydroponic supplying systems on the yield and quality of vegetables. Four articles investigated the effects of environmental conditions (mainly light and temperature) on the growth and quality of vegetables. In terms of degenerated greenhouse soil, three articles showed how reductive soil disinfestation decreased soil salinity, improved soil quality, and inactivated soil-borne pathogens.
    Keywords: daily light integral ; cucumber seedling ; seedling quality ; flower development ; boron ; application methods ; growth ; fruit quality ; tomato ; protected greenhouse ; soilless culture ; poultry manure ; yield enhancement ; cucumber ; univariate analysis ; multivariate analysis ; nutrient uptake ; sweet onion ; nerokremmydo ; aeroponic ; floating ; nutrient film technique ; bulb ; application rate ; nitrate ; organic acid ; soil-borne pathogens ; soil pH ; sulfate ; growth rate ; root morphology ; ammonium to nitrate ratio ; nutrient solution composition ; nitrogen efficiency ; net assimilation rate (NAR) ; leaf nitrogen ; fruit temperature ; dry matter ; chlorophyll ; microbial activity ; organic fertilizer ; plastic shed cultivation system ; reductive soil disinfestation ; soil quality ; aromatic substances ; carbon exportation ; flavor quality ; nutrient and function indicator ; overall appearance ; microbial community ; microbial function ; co-occurrence network ; soil ecosystem ; alternate drip irrigation under mulch ; water ; zeolite amount ; tomato growth ; water use efficiency ; principal component ; solar radiation ; humidity ; temperature ; irrigation water use efficiency ; yield ; n/a ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences
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