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  • United States  (5,912)
  • Male  (4,899)
  • Engineering
  • American Association for the Advancement of Science (AAAS)  (10,600)
  • Santa Maria, CA  (47)
  • 1
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    Historical Diving Society U.S.A. | Santa Maria, CA
    In:  http://aquaticcommons.org/id/eprint/15259 | 29 | 2014-06-14 00:00:04 | 15259 | Historical Diving Society U.S.A.
    Publication Date: 2021-07-05
    Description: Official publication of the Historical Diving Society U.S.A. and affiliated societies. Succeeded by the Journal of Diving History with issue no. 55 (2008).
    Keywords: Engineering ; SCUBA diving ; hard hat diving ; hardhat diving ; history
    Repository Name: AquaDocs
    Type: monograph
    Format: application/pdf
    Format: application/pdf
    Format: 52
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  • 2
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    Historical Diving Society U.S.A. | Santa Maria, CA
    In:  http://aquaticcommons.org/id/eprint/15260 | 29 | 2014-06-14 00:05:45 | 15260 | Historical Diving Society U.S.A.
    Publication Date: 2021-07-05
    Description: Official publication of the Historical Diving Society U.S.A. and affiliated societies. Succeeded by the Journal of Diving History with issue no. 55 (2008).
    Keywords: Engineering ; SCUBA diving ; hard hat diving ; hardhat diving ; history
    Repository Name: AquaDocs
    Type: monograph
    Format: application/pdf
    Format: application/pdf
    Format: 56
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  • 3
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    Historical Diving Society U.S.A. | Santa Maria, CA
    In:  http://aquaticcommons.org/id/eprint/15258 | 29 | 2014-06-13 23:37:32 | 15258 | Historical Diving Society U.S.A.
    Publication Date: 2021-07-05
    Description: Official publication of the Historical Diving Society U.S.A. and affiliated societies. Succeeded by the Journal of Diving History with issue no. 55 (2008).
    Keywords: Engineering ; SCUBA diving ; hard hat diving ; hardhat diving ; history
    Repository Name: AquaDocs
    Type: monograph
    Format: application/pdf
    Format: application/pdf
    Format: 52
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  • 4
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    Historical Diving Society U.S.A. | Santa Maria, CA
    In:  http://aquaticcommons.org/id/eprint/15266 | 29 | 2014-07-16 17:56:00 | 15266 | Historical Diving Society U.S.A.
    Publication Date: 2021-07-05
    Description: Official publication of the Historical Diving Society U.S.A. and affiliated societies. Succeeded by the Journal of Diving History with issue no. 55 (2008).
    Keywords: Engineering ; SCUBA diving ; hard hat diving ; hardhat diving ; history
    Repository Name: AquaDocs
    Type: monograph
    Format: application/pdf
    Format: application/pdf
    Format: 52
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  • 5
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    Historical Diving Society U.S.A. | Santa Maria, CA
    In:  http://aquaticcommons.org/id/eprint/15261 | 29 | 2014-06-14 00:10:47 | 15261 | Historical Diving Society U.S.A.
    Publication Date: 2021-07-05
    Description: Official publication of the Historical Diving Society U.S.A. and affiliated societies. Succeeded by the Journal of Diving History with issue no. 55 (2008).
    Keywords: Engineering ; SCUBA diving ; hard hat diving ; hardhat diving ; history
    Repository Name: AquaDocs
    Type: monograph
    Format: application/pdf
    Format: application/pdf
    Format: 56
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  • 6
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    Historical Diving Society U.S.A. | Santa Maria, CA
    In:  http://aquaticcommons.org/id/eprint/15262 | 29 | 2014-06-16 16:57:42 | 15262 | Historical Diving Society U.S.A.
    Publication Date: 2021-07-05
    Description: Official publication of the Historical Diving Society U.S.A. and affiliated societies. Succeeded by the Journal of Diving History with issue no. 55 (2008).
    Keywords: Engineering ; SCUBA diving ; hard hat diving ; hardhat diving ; history
    Repository Name: AquaDocs
    Type: monograph
    Format: application/pdf
    Format: application/pdf
    Format: 48
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  • 7
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    Historical Diving Society U.S.A. | Santa Maria, CA
    In:  http://aquaticcommons.org/id/eprint/15265 | 29 | 2014-07-16 17:49:34 | 15265 | Historical Diving Society U.S.A.
    Publication Date: 2021-07-05
    Description: Official publication of the Historical Diving Society U.S.A. and affiliated societies. Succeeded by the Journal of Diving History with issue no. 55 (2008).
    Keywords: Engineering ; SCUBA diving ; hard hat diving ; hardhat diving ; history
    Repository Name: AquaDocs
    Type: monograph
    Format: application/pdf
    Format: application/pdf
    Format: 56
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  • 8
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    Historical Diving Society U.S.A. | Santa Maria, CA
    In:  http://aquaticcommons.org/id/eprint/15267 | 29 | 2014-07-17 17:19:05 | 15267 | Historical Diving Society U.S.A.
    Publication Date: 2021-07-05
    Description: Official publication of the Historical Diving Society U.S.A. and affiliated societies. Formerly Historical Diver Magazine for issues no. 1-54 (1993-2008).
    Keywords: Engineering ; SCUBA diving ; hard hat diving ; hardhat diving ; history
    Repository Name: AquaDocs
    Type: monograph
    Format: application/pdf
    Format: application/pdf
    Format: 64
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  • 9
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    Historical Diving Society U.S.A. | Santa Maria, CA
    In:  http://aquaticcommons.org/id/eprint/15263 | 29 | 2014-06-16 17:03:55 | 15263 | Historical Diving Society U.S.A.
    Publication Date: 2021-07-05
    Description: Official publication of the Historical Diving Society U.S.A. and affiliated societies. Succeeded by the Journal of Diving History with issue no. 55 (2008).
    Keywords: Engineering ; SCUBA diving ; hard hat diving ; hardhat diving ; history
    Repository Name: AquaDocs
    Type: monograph
    Format: application/pdf
    Format: application/pdf
    Format: 60
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  • 10
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    Historical Diving Society U.S.A. | Santa Maria, CA
    In:  http://aquaticcommons.org/id/eprint/15264 | 29 | 2014-07-16 17:46:25 | 15264 | Historical Diving Society U.S.A.
    Publication Date: 2021-07-05
    Description: Official publication of the Historical Diving Society U.S.A. and affiliated societies. Succeeded by the Journal of Diving History with issue no. 55 (2008).
    Keywords: Engineering ; SCUBA diving ; hard hat diving ; hardhat diving ; history
    Repository Name: AquaDocs
    Type: monograph
    Format: application/pdf
    Format: application/pdf
    Format: 56
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  • 11
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    Historical Diving Society U.S.A. | Santa Maria, CA
    In:  http://aquaticcommons.org/id/eprint/15278 | 29 | 2014-07-17 20:56:58 | 15278 | Historical Diving Society U.S.A.
    Publication Date: 2021-07-05
    Description: Official publication of the Historical Diving Society U.S.A. and affiliated societies. Formerly Historical Diver Magazine for issues no. 1-54 (1993-2008).
    Keywords: Engineering ; SCUBA diving ; hard hat diving ; hardhat diving ; history
    Repository Name: AquaDocs
    Type: monograph
    Format: application/pdf
    Format: application/pdf
    Format: 48
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  • 12
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    Historical Diving Society U.S.A. | Santa Maria, CA
    In:  http://aquaticcommons.org/id/eprint/15276 | 29 | 2014-07-17 17:24:30 | 15276 | Historical Diving Society U.S.A.
    Publication Date: 2021-07-05
    Description: Official publication of the Historical Diving Society U.S.A. and affiliated societies. Formerly Historical Diver Magazine for issues no. 1-54 (1993-2008).
    Keywords: Engineering ; SCUBA diving ; hard hat diving ; hardhat diving ; history
    Repository Name: AquaDocs
    Type: monograph
    Format: application/pdf
    Format: application/pdf
    Format: 60
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  • 13
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    Historical Diving Society U.S.A. | Santa Maria, CA
    In:  http://aquaticcommons.org/id/eprint/15279 | 29 | 2014-07-17 21:01:47 | 15279 | Historical Diving Society U.S.A.
    Publication Date: 2021-07-05
    Description: Official publication of the Historical Diving Society U.S.A. and affiliated societies. Formerly Historical Diver Magazine for issues no. 1-54 (1993-2008).
    Keywords: Engineering ; SCUBA diving ; hard hat diving ; hardhat diving ; history
    Repository Name: AquaDocs
    Type: monograph
    Format: application/pdf
    Format: application/pdf
    Format: 48
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  • 14
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    Historical Diving Society U.S.A. | Santa Maria, CA
    In:  http://aquaticcommons.org/id/eprint/15277 | 29 | 2014-07-17 17:30:51 | 15277 | Historical Diving Society U.S.A.
    Publication Date: 2021-07-05
    Description: Official publication of the Historical Diving Society U.S.A. and affiliated societies. Formerly Historical Diver Magazine for issues no. 1-54 (1993-2008).
    Keywords: Engineering ; SCUBA diving ; hard hat diving ; hardhat diving ; history
    Repository Name: AquaDocs
    Type: monograph
    Format: application/pdf
    Format: application/pdf
    Format: 56
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  • 15
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    Historical Diving Society U.S.A. | Santa Maria, CA
    In:  http://aquaticcommons.org/id/eprint/15280 | 29 | 2014-07-17 21:05:09 | 15280 | Historical Diving Society U.S.A.
    Publication Date: 2021-07-05
    Description: Official publication of the Historical Diving Society U.S.A. and affiliated societies. Formerly Historical Diver Magazine for issues no. 1-54 (1993-2008).
    Keywords: Engineering ; SCUBA diving ; hard hat diving ; hardhat diving ; history
    Repository Name: AquaDocs
    Type: monograph
    Format: application/pdf
    Format: application/pdf
    Format: 48
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  • 16
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    Historical Diving Society U.S.A. | Santa Maria, CA
    In:  http://aquaticcommons.org/id/eprint/15282 | 29 | 2014-08-04 17:20:33 | 15282 | Historical Diving Society U.S.A.
    Publication Date: 2021-07-05
    Description: Official publication of the Historical Diving Society U.S.A. and affiliated societies. Formerly Historical Diver Magazine for issues no. 1-54 (1993-2008).
    Keywords: Engineering ; SCUBA diving ; hard hat diving ; hardhat diving ; history
    Repository Name: AquaDocs
    Type: monograph
    Format: application/pdf
    Format: application/pdf
    Format: 48
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  • 17
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    Historical Diving Society U.S.A. | Santa Maria, CA
    In:  http://aquaticcommons.org/id/eprint/15283 | 29 | 2014-08-04 17:27:48 | 15283 | Historical Diving Society U.S.A.
    Publication Date: 2021-07-05
    Description: Official publication of the Historical Diving Society U.S.A. and affiliated societies. Formerly Historical Diver Magazine for issues no. 1-54 (1993-2008).
    Keywords: Engineering ; SCUBA diving ; hard hat diving ; hardhat diving ; history
    Repository Name: AquaDocs
    Type: monograph
    Format: application/pdf
    Format: application/pdf
    Format: 52
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  • 18
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    Historical Diving Society U.S.A. | Santa Maria, CA
    In:  http://aquaticcommons.org/id/eprint/15290 | 29 | 2015-01-15 19:56:48 | 15290 | Historical Diving Society U.S.A.
    Publication Date: 2021-07-05
    Description: Official publication of the Historical Diving Society U.S.A. and affiliated societies. Formerly Historical Diver Magazine for issues no. 1-54 (1993-2008).
    Keywords: Engineering ; SCUBA diving ; hard hat diving ; hardhat diving ; history
    Repository Name: AquaDocs
    Type: monograph
    Format: application/pdf
    Format: application/pdf
    Format: 72
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  • 19
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    Historical Diving Society U.S.A. | Santa Maria, CA
    In:  http://aquaticcommons.org/id/eprint/15286 | 29 | 2014-08-04 23:28:23 | 15286 | Historical Diving Society U.S.A.
    Publication Date: 2021-07-05
    Description: Official publication of the Historical Diving Society U.S.A. and affiliated societies. Formerly Historical Diver Magazine for issues no. 1-54 (1993-2008).
    Keywords: Engineering ; SCUBA diving ; hard hat diving ; hardhat diving ; history
    Repository Name: AquaDocs
    Type: monograph
    Format: application/pdf
    Format: application/pdf
    Format: 64
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  • 20
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    Historical Diving Society U.S.A. | Santa Maria, CA
    In:  http://aquaticcommons.org/id/eprint/15284 | 29 | 2014-08-04 17:32:46 | 15284 | Historical Diving Society U.S.A.
    Publication Date: 2021-07-05
    Description: Official publication of the Historical Diving Society U.S.A. and affiliated societies. Formerly Historical Diver Magazine for issues no. 1-54 (1993-2008).
    Keywords: Engineering ; SCUBA diving ; hard hat diving ; hardhat diving ; history
    Repository Name: AquaDocs
    Type: monograph
    Format: application/pdf
    Format: application/pdf
    Format: 52
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  • 21
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    Historical Diving Society U.S.A. | Santa Maria, CA
    In:  http://aquaticcommons.org/id/eprint/15289 | 29 | 2014-08-04 23:42:53 | 15289 | Historical Diving Society U.S.A.
    Publication Date: 2021-07-05
    Description: Official publication of the Historical Diving Society U.S.A. and affiliated societies. Formerly Historical Diver Magazine for issues no. 1-54 (1993-2008).
    Keywords: Engineering ; SCUBA diving ; hard hat diving ; hardhat diving ; history
    Repository Name: AquaDocs
    Type: monograph
    Format: application/pdf
    Format: application/pdf
    Format: 56
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  • 22
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    Historical Diving Society U.S.A. | Santa Maria, CA
    In:  http://aquaticcommons.org/id/eprint/15281 | 29 | 2014-07-30 17:00:50 | 15281 | Historical Diving Society U.S.A.
    Publication Date: 2021-07-05
    Description: Official publication of the Historical Diving Society U.S.A. and affiliated societies. Formerly Historical Diver Magazine for issues no. 1-54 (1993-2008).
    Keywords: Engineering ; SCUBA diving ; hard hat diving ; hardhat diving ; history
    Repository Name: AquaDocs
    Type: monograph
    Format: application/pdf
    Format: application/pdf
    Format: 44
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  • 23
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    Historical Diving Society U.S.A. | Santa Maria, CA
    In:  http://aquaticcommons.org/id/eprint/15287 | 29 | 2014-08-04 23:32:13 | 15287 | Historical Diving Society U.S.A.
    Publication Date: 2021-07-05
    Description: Official publication of the Historical Diving Society U.S.A. and affiliated societies. Formerly Historical Diver Magazine for issues no. 1-54 (1993-2008).
    Keywords: Engineering ; SCUBA diving ; hard hat diving ; hardhat diving ; history
    Repository Name: AquaDocs
    Type: monograph
    Format: application/pdf
    Format: application/pdf
    Format: 60
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  • 24
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    Historical Diving Society U.S.A. | Santa Maria, CA
    In:  http://aquaticcommons.org/id/eprint/15285 | 29 | 2014-08-04 20:51:25 | 15285 | Historical Diving Society U.S.A.
    Publication Date: 2021-07-05
    Description: Official publication of the Historical Diving Society U.S.A. and affiliated societies. Formerly Historical Diver Magazine for issues no. 1-54 (1993-2008).
    Keywords: Engineering ; SCUBA diving ; hard hat diving ; hardhat diving ; history
    Repository Name: AquaDocs
    Type: monograph
    Format: application/pdf
    Format: application/pdf
    Format: 56
    Location Call Number Expected Availability
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  • 25
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    Historical Diving Society U.S.A. | Santa Maria, CA
    In:  http://aquaticcommons.org/id/eprint/15291 | 29 | 2014-08-05 17:21:32 | 15291 | Historical Diving Society U.S.A.
    Publication Date: 2021-07-05
    Description: Official publication of the Historical Diving Society U.S.A. and affiliated societies. Formerly Historical Diver Magazine for issues no. 1-54 (1993-2008).
    Keywords: Engineering ; SCUBA diving ; hard hat diving ; hardhat diving ; history
    Repository Name: AquaDocs
    Type: monograph
    Format: application/pdf
    Format: application/pdf
    Format: 70
    Location Call Number Expected Availability
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  • 26
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    Historical Diving Society U.S.A. | Santa Maria, CA
    In:  http://aquaticcommons.org/id/eprint/15292 | 29 | 2014-08-05 17:24:24 | 15292 | Historical Diving Society U.S.A.
    Publication Date: 2021-07-05
    Description: Official publication of the Historical Diving Society U.S.A. and affiliated societies. Formerly Historical Diver Magazine for issues no. 1-54 (1993-2008).
    Keywords: Engineering ; SCUBA diving ; hard hat diving ; hardhat diving ; history
    Repository Name: AquaDocs
    Type: monograph
    Format: application/pdf
    Format: application/pdf
    Format: 70
    Location Call Number Expected Availability
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  • 27
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    Historical Diving Society U.S.A. | Santa Maria, CA
    In:  http://aquaticcommons.org/id/eprint/15293 | 29 | 2014-08-05 17:27:26 | 15293 | Historical Diving Society U.S.A.
    Publication Date: 2021-07-05
    Description: Official publication of the Historical Diving Society U.S.A. and affiliated societies. Formerly Historical Diver Magazine for issues no. 1-54 (1993-2008).
    Keywords: Engineering ; SCUBA diving ; hard hat diving ; hardhat diving ; history
    Repository Name: AquaDocs
    Type: monograph
    Format: application/pdf
    Format: application/pdf
    Format: 72
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  • 28
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    Historical Diving Society U.S.A. | Santa Maria, CA
    In:  http://aquaticcommons.org/id/eprint/15288 | 29 | 2014-08-04 23:36:47 | 15288 | Historical Diving Society U.S.A.
    Publication Date: 2021-07-05
    Description: Official publication of the Historical Diving Society U.S.A. and affiliated societies. Formerly Historical Diver Magazine for issues no. 1-54 (1993-2008).
    Keywords: Engineering ; SCUBA diving ; hard hat diving ; hardhat diving ; history
    Repository Name: AquaDocs
    Type: monograph
    Format: application/pdf
    Format: application/pdf
    Format: 60
    Location Call Number Expected Availability
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  • 29
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    Historical Diving Society U.S.A. | Santa Maria, CA
    In:  http://aquaticcommons.org/id/eprint/15295 | 29 | 2015-04-08 22:12:55 | 15295 | Historical Diving Society U.S.A.
    Publication Date: 2021-07-05
    Description: Official publication of the Historical Diving Society U.S.A. and affiliated societies. Formerly Historical Diver Magazine for issues no. 1-54 (1993-2008).
    Keywords: Engineering ; SCUBA diving ; hard hat diving ; hardhat diving ; history
    Repository Name: AquaDocs
    Type: monograph
    Format: application/pdf
    Format: application/pdf
    Format: 68
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  • 30
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    Historical Diving Society U.S.A. | Santa Maria, CA
    In:  http://aquaticcommons.org/id/eprint/15296 | 29 | 2015-06-19 00:18:40 | 15296 | Historical Diving Society U.S.A.
    Publication Date: 2021-07-05
    Description: Official publication of the Historical Diving Society U.S.A. and affiliated societies. Formerly Historical Diver Magazine for issues no. 1-54 (1993-2008).
    Keywords: Engineering ; SCUBA diving ; hard hat diving ; hardhat diving ; history
    Repository Name: AquaDocs
    Type: monograph
    Format: application/pdf
    Format: application/pdf
    Format: 70
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  • 31
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    Historical Diving Society U.S.A. | Santa Maria, CA
    In:  http://aquaticcommons.org/id/eprint/15294 | 29 | 2015-01-15 19:57:33 | 15294 | Historical Diving Society U.S.A.
    Publication Date: 2021-07-05
    Description: Official publication of the Historical Diving Society U.S.A. and affiliated societies. Formerly Historical Diver Magazine for issues no. 1-54 (1993-2008).
    Keywords: Engineering ; SCUBA diving ; hard hat diving ; hardhat diving ; history
    Repository Name: AquaDocs
    Type: monograph
    Format: application/pdf
    Format: application/pdf
    Format: 74
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  • 32
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    Historical Diving Society U.S.A. | Santa Maria, CA
    In:  http://aquaticcommons.org/id/eprint/15297 | 29 | 2016-10-24 17:41:14 | 15297 | Historical Diving Society U.S.A.
    Publication Date: 2021-07-05
    Description: Official publication of the Historical Diving Society U.S.A. and affiliated societies. Formerly Historical Diver Magazine for issues no. 1-54 (1993-2008).
    Keywords: Engineering ; SCUBA diving ; hard hat diving ; hardhat diving ; history
    Repository Name: AquaDocs
    Type: monograph
    Format: application/pdf
    Format: application/pdf
    Format: 66
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  • 33
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    Historical Diving Society U.S.A. | Santa Maria, CA
    In:  http://aquaticcommons.org/id/eprint/15354 | 29 | 2016-10-24 17:46:11 | 15354 | Historical Diving Society U.S.A.
    Publication Date: 2021-07-06
    Description: Official publication of the Historical Diving Society U.S.A. and affiliated societies. Formerly Historical Diver Magazine for issues no. 1-54 (1993-2008).
    Keywords: Engineering ; SCUBA diving ; hard hat diving ; hardhat diving ; history
    Repository Name: AquaDocs
    Type: monograph
    Format: application/pdf
    Format: application/pdf
    Format: 68
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  • 34
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    Historical Diving Society U.S.A. | Santa Maria, CA
    In:  http://aquaticcommons.org/id/eprint/15455 | 29 | 2016-10-24 17:50:37 | 15455 | Historical Diving Society U.S.A.
    Publication Date: 2021-07-07
    Description: Official publication of the Historical Diving Society U.S.A. and affiliated societies. Formerly Historical Diver Magazine for issues no. 1-54 (1993-2008).
    Keywords: Engineering ; SCUBA diving ; hard hat diving ; hardhat diving ; history
    Repository Name: AquaDocs
    Type: monograph
    Format: application/pdf
    Format: application/pdf
    Format: 68
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  • 35
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    Historical Diving Society U.S.A. | Santa Maria, CA
    In:  http://aquaticcommons.org/id/eprint/15075 | 29 | 2014-06-02 19:57:56 | 15075 | Historical Diving Society U.S.A.
    Publication Date: 2021-07-02
    Description: Official publication of the Historical Diving Society U.S.A. and affiliated societies. Succeeded by the Journal of Diving History with issue no. 55 (2008).
    Keywords: Engineering ; SCUBA diving ; hard hat diving ; hardhat diving ; history
    Repository Name: AquaDocs
    Type: monograph
    Format: application/pdf
    Format: application/pdf
    Format: 56
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  • 36
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    Historical Diving Society U.S.A. | Santa Maria, CA
    In:  http://aquaticcommons.org/id/eprint/15074 | 29 | 2014-06-02 19:45:49 | 15074 | Historical Diving Society U.S.A.
    Publication Date: 2021-07-02
    Description: Official publication of the Historical Diving Society U.S.A. and affiliated societies. Succeeded by the Journal of Diving History with issue no. 55 (2008).
    Keywords: Engineering ; SCUBA diving ; hard hat diving ; hardhat diving ; history
    Repository Name: AquaDocs
    Type: monograph
    Format: application/pdf
    Format: application/pdf
    Format: 64
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  • 37
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    Historical Diving Society U.S.A. | Santa Maria, CA
    In:  http://aquaticcommons.org/id/eprint/15076 | 29 | 2014-06-02 20:05:25 | 15076 | Historical Diving Society U.S.A.
    Publication Date: 2021-07-02
    Description: Official publication of the Historical Diving Society U.S.A. and affiliated societies. Succeeded by the Journal of Diving History with issue no. 55 (2008).
    Keywords: Engineering ; SCUBA diving ; hard hat diving ; hardhat diving ; history
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    Historical Diving Society U.S.A. | Santa Maria, CA
    In:  http://aquaticcommons.org/id/eprint/15083 | 29 | 2014-08-04 20:57:18 | 15083 | Historical Diving Society U.S.A.
    Publication Date: 2021-07-02
    Description: Official publication of the Historical Diving Society U.S.A. and affiliated societies. Succeeded by the Journal of Diving History with issue no. 55 (2008).
    Keywords: Engineering ; SCUBA diving ; hard hat diving ; hardhat diving ; history
    Repository Name: AquaDocs
    Type: monograph
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    Historical Diving Society U.S.A. | Santa Maria, CA
    In:  http://aquaticcommons.org/id/eprint/16629 | 29 | 2016-10-24 17:58:52 | 16629 | Historical Diving Society U.S.A.
    Publication Date: 2021-07-07
    Description: Official publication of the Historical Diving Society U.S.A. and affiliated societies. Formerly Historical Diver Magazine for issues no. 1-54 (1993-2008).
    Keywords: Engineering ; SCUBA diving ; hard hat diving ; hardhat diving ; history
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    Historical Diving Society U.S.A. | Santa Maria, CA
    In:  http://aquaticcommons.org/id/eprint/17287 | 29 | 2016-10-27 22:38:13 | 17287 | Historical Diving Society U.S.A.
    Publication Date: 2021-07-11
    Description: Official publication of the Historical Diving Society U.S.A. and affiliated societies. Formerly Historical Diver Magazine for issues no. 1-54 (1993-2008).
    Keywords: Engineering ; SCUBA diving ; hard hat diving ; hardhat diving ; history
    Repository Name: AquaDocs
    Type: monograph
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    Historical Diving Society U.S.A. | Santa Maria, CA
    In:  http://aquaticcommons.org/id/eprint/15874 | 29 | 2016-10-24 17:53:41 | 15874 | Historical Diving Society U.S.A.
    Publication Date: 2021-07-11
    Description: Official publication of the Historical Diving Society U.S.A. and affiliated societies. Formerly Historical Diver Magazine for issues no. 1-54 (1993-2008).
    Keywords: Engineering ; SCUBA diving ; hard hat diving ; hardhat diving ; history
    Repository Name: AquaDocs
    Type: monograph
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    Historical Diving Society U.S.A. | Santa Maria, CA
    In:  http://aquaticcommons.org/id/eprint/21088 | 29 | 2020-05-11 17:42:49 | 21088 | Historical Diving Society U.S.A.
    Publication Date: 2021-07-14
    Description: Official publication of the Historical Diving Society U.S.A. and affiliated societies. Formerly Historical Diver Magazine for issues no. 1-54 (1993-2008).
    Keywords: Engineering ; SCUBA diving ; hard hat diving ; hardhat diving ; history
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    Historical Diving Society U.S.A. | Santa Maria, CA
    In:  http://aquaticcommons.org/id/eprint/21086 | 29 | 2020-05-11 17:37:40 | 21086 | Historical Diving Society U.S.A.
    Publication Date: 2021-07-14
    Description: Official publication of the Historical Diving Society U.S.A. and affiliated societies. Formerly Historical Diver Magazine for issues no. 1-54 (1993-2008).
    Keywords: Engineering ; SCUBA diving ; hard hat diving ; hardhat diving ; history
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    Historical Diving Society U.S.A. | Santa Maria, CA
    In:  http://aquaticcommons.org/id/eprint/21083 | 29 | 2017-02-08 21:04:08 | 21083 | Historical Diving Society U.S.A.
    Publication Date: 2021-07-14
    Description: Official publication of the Historical Diving Society U.S.A. and affiliated societies. Formerly Historical Diver Magazine for issues no. 1-54 (1993-2008).
    Keywords: Engineering ; SCUBA diving ; hard hat diving ; hardhat diving ; history
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    Type: monograph
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    Historical Diving Society U.S.A. | Santa Maria, CA
    In:  http://aquaticcommons.org/id/eprint/21084 | 29 | 2020-05-11 17:32:34 | 21084 | Historical Diving Society U.S.A.
    Publication Date: 2021-07-14
    Description: Official publication of the Historical Diving Society U.S.A. and affiliated societies. Formerly Historical Diver Magazine for issues no. 1-54 (1993-2008).
    Keywords: Engineering ; SCUBA diving ; hard hat diving ; hardhat diving ; history
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    Type: monograph
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    Historical Diving Society U.S.A. | Santa Maria, CA
    In:  http://aquaticcommons.org/id/eprint/21085 | 29 | 2020-05-11 17:34:44 | 21085 | Historical Diving Society U.S.A.
    Publication Date: 2021-07-14
    Description: Official publication of the Historical Diving Society U.S.A. and affiliated societies. Formerly Historical Diver Magazine for issues no. 1-54 (1993-2008).
    Keywords: Engineering ; SCUBA diving ; hard hat diving ; hardhat diving ; history
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    Historical Diving Society U.S.A. | Santa Maria, CA
    In:  http://aquaticcommons.org/id/eprint/21087 | 29 | 2020-05-11 17:40:52 | 21087 | Historical Diving Society U.S.A.
    Publication Date: 2021-07-14
    Description: Official publication of the Historical Diving Society U.S.A. and affiliated societies. Formerly Historical Diver Magazine for issues no. 1-54 (1993-2008).
    Keywords: Engineering ; SCUBA diving ; hard hat diving ; hardhat diving ; history
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    Type: monograph
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  • 48
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    American Association for the Advancement of Science (AAAS)
    In: Science
    Publication Date: 2018-08-17
    Keywords: Engineering
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 49
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    American Association for the Advancement of Science (AAAS)
    In: Science
    Publication Date: 2018-08-17
    Description: Polyamide thickness and roughness have been identified as critical properties that affect thin-film composite membrane performance for reverse osmosis. Conventional formation methodologies lack the ability to control these properties independently with high resolution or precision. An additive approach is presented that uses electrospraying to deposit monomers directly onto a substrate, where they react to form polyamide. The small droplet size coupled with low monomer concentrations result in polyamide films that are smoother and thinner than conventional polyamides, while the additive nature of the approach allows for control of thickness and roughness. Polyamide films are formed with a thickness that is controllable down to 4-nanometer increments and a roughness as low as 2 nanometers while still exhibiting good permselectivity relative to a commercial benchmarking membrane.
    Keywords: Engineering
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  • 50
    Publication Date: 2018-09-07
    Description: Zeolitic imidazolate framework (ZIF) membranes are emerging as a promising energy-efficient separation technology. However, their reliable and scalable manufacturing remains a challenge. We demonstrate the fabrication of ZIF nanocomposite membranes by means of an all-vapor-phase processing method based on atomic layer deposition (ALD) of ZnO in a porous support followed by ligand-vapor treatment. After ALD, the obtained nanocomposite exhibits low flux and is not selective, whereas after ligand-vapor (2-methylimidazole) treatment, it is partially transformed to ZIF and shows stable performance with high mixture separation factor for propylene over propane (an energy-intensive high-volume separation) and high propylene flux. Membrane synthesis through ligand-induced permselectivation of a nonselective and impermeable deposit is shown to be simple and highly reproducible and holds promise for scalability.
    Keywords: Engineering
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    American Association for the Advancement of Science (AAAS)
    In: Science
    Publication Date: 2018-09-14
    Keywords: Engineering
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 52
    Publication Date: 2018-09-14
    Description: Insects are among the most agile natural flyers. Hypotheses on their flight control cannot always be validated by experiments with animals or tethered robots. To this end, we developed a programmable and agile autonomous free-flying robot controlled through bio-inspired motion changes of its flapping wings. Despite being 55 times the size of a fruit fly, the robot can accurately mimic the rapid escape maneuvers of flies, including a correcting yaw rotation toward the escape heading. Because the robot’s yaw control was turned off, we showed that these yaw rotations result from passive, translation-induced aerodynamic coupling between the yaw torque and the roll and pitch torques produced throughout the maneuver. The robot enables new methods for studying animal flight, and its flight characteristics allow for real-world flight missions.
    Keywords: Engineering
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    American Association for the Advancement of Science (AAAS)
    In: Science
    Publication Date: 2018-04-27
    Keywords: Engineering
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
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    American Association for the Advancement of Science (AAAS)
    In: Science
    Publication Date: 2018-09-14
    Keywords: Engineering
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
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    American Association for the Advancement of Science (AAAS)
    In: Science
    Publication Date: 2018-03-09
    Keywords: Engineering
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    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
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    American Association for the Advancement of Science (AAAS)
    In: Science
    Publication Date: 2018-01-19
    Keywords: Engineering
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    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 57
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    American Association for the Advancement of Science (AAAS)
    In: Science
    Publication Date: 2017-06-23
    Keywords: Engineering
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
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    American Association for the Advancement of Science (AAAS)
    In: Science
    Publication Date: 2017-06-23
    Keywords: Engineering
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 59
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    American Association for the Advancement of Science (AAAS)
    In: Science
    Publication Date: 2017-06-16
    Keywords: Engineering
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 60
    Publication Date: 2017-06-23
    Description: Exoskeletons and active prostheses promise to enhance human mobility, but few have succeeded. Optimizing device characteristics on the basis of measured human performance could lead to improved designs. We have developed a method for identifying the exoskeleton assistance that minimizes human energy cost during walking. Optimized torque patterns from an exoskeleton worn on one ankle reduced metabolic energy consumption by 24.2 ± 7.4% compared to no torque. The approach was effective with exoskeletons worn on one or both ankles, during a variety of walking conditions, during running, and when optimizing muscle activity. Finding a good generic assistance pattern, customizing it to individual needs, and helping users learn to take advantage of the device all contributed to improved economy. Optimization methods with these features can substantially improve performance.
    Keywords: Engineering
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    American Association for the Advancement of Science (AAAS)
    In: Science
    Publication Date: 2017-11-24
    Keywords: Engineering
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    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 62
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    American Association for the Advancement of Science (AAAS)
    In: Science
    Publication Date: 2017-12-01
    Description: Kim et al . (Reports, 28 April 2017, p. 430) presented results for the solar-driven harvesting of water from air via metal-organic frameworks as a prodigious potential advance toward remedying global water shortages. Basic thermodynamics and a survey of multiple off-the-shelf technologies show that their approach is vastly inferior in efficiency (and thereby in feasibility) to available alternatives.
    Keywords: Engineering
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  • 63
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    American Association for the Advancement of Science (AAAS)
    In: Science
    Publication Date: 2017-12-01
    Keywords: Engineering
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 64
    Publication Date: 2017-12-01
    Description: In their comment, Bui et al . argue that the approach we described in our report is vastly inferior in efficiency to alternative off-the-shelf technologies. Their conclusion is invalid, as they compare efficiencies in completely different operating conditions. Here, using heat transfer and thermodynamics principles, we show how Bui et al .’s conclusions about the efficiencies of off-the-shelf technologies are fundamentally flawed and inaccurate for the operating conditions described in our study.
    Keywords: Engineering
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  • 65
    Publication Date: 2017-05-12
    Description: Bacteria within communities can interact to organize their behavior. It has been unclear whether such interactions can extend beyond a single community to coordinate the behavior of distant populations. We discovered that two Bacillus subtilis biofilm communities undergoing metabolic oscillations can become coupled through electrical signaling and synchronize their growth dynamics. Coupling increases competition by also synchronizing demand for limited nutrients. As predicted by mathematical modeling, we confirm that biofilms resolve this conflict by switching from in-phase to antiphase oscillations. This results in time-sharing behavior, where each community takes turns consuming nutrients. Time-sharing enables biofilms to counterintuitively increase growth under reduced nutrient supply. Distant biofilms can thus coordinate their behavior to resolve nutrient competition through time-sharing, a strategy used in engineered systems to allocate limited resources.
    Keywords: Engineering
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    American Association for the Advancement of Science (AAAS)
    In: Science
    Publication Date: 2017-05-12
    Keywords: Engineering
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
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    American Association for the Advancement of Science (AAAS)
    In: Science
    Publication Date: 2017-02-17
    Description: Engineering has an image problem. The phrase "engineering disaster" rolls off the tongue, while great technical achievements are more often heralded as "scientific miracles." Enter Dream Big. Sponsored by the American Society of Civil Engineers with support from Bechtel Corporation, the film sets out to reframe engineering as a force for good and a profession in service to people and the planet. Author: Donna Riley
    Keywords: Engineering
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    American Association for the Advancement of Science (AAAS)
    In: Science
    Publication Date: 2017-07-21
    Keywords: Engineering
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 69
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    American Association for the Advancement of Science (AAAS)
    In: Science
    Publication Date: 2017-07-21
    Keywords: Engineering
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
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    American Association for the Advancement of Science (AAAS)
    In: Science
    Publication Date: 2017-05-26
    Keywords: Engineering
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    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
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    American Association for the Advancement of Science (AAAS)
    In: Science
    Publication Date: 2017-11-10
    Keywords: Engineering
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 72
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    American Association for the Advancement of Science (AAAS)
    In: Science
    Publication Date: 2016-07-08
    Description: The Internet connects billions of computational platforms of various sizes, from supercomputers to smart phones. However, the same types of data transmission can connect computational resources to much simpler sensors “at the edge of the net” that collect, analyze, and transmit data, as well as controllers that receive instructions. Devices deployed in the environment, homes and offices, and even our bodies would expand the number of connected devices to the trillions. This “Internet of Things” (IoT) underlies the vision of smart homes and buildings that could sense and transmit their status and respond appropriately (1), or track and report on the state of objects (vehicles, goods, or even animals) in the environment. However, the practical implementation of the IoT has been relatively slow, in part because all of these edge devices must draw electrical power from their local environment. We analyze the use of photovoltaics (PV) to power devices and help bring the IoT to fruition. Authors: Richard Haight, Wilfried Haensch, Daniel Friedman
    Keywords: Engineering
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 73
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    American Association for the Advancement of Science (AAAS)
    In: Science
    Publication Date: 2016-04-22
    Description: So prized by the ancient Romans were Egyptian obelisks that, at one time, more of them stood in Rome than in Egypt. In the 19th century, France, Britain, and the United States—inspired by Napoleon Bonaparte's expedition to Egypt in 1798— acquired their own major obelisks from Alexandria and Luxor. Cleopatra's Needles, by Egyptologist Bob Brier, explores the engineering challenges associated with building and erecting these massive monuments. Author: Andrew Robinson
    Keywords: Engineering
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  • 74
    Publication Date: 2016-01-20
    Description: Massive open online courses (MOOCs) are often characterized as remedies to educational disparities related to social class. Using data from 68 MOOCs offered by Harvard and MIT between 2012 and 2014, we found that course participants from the United States tended to live in more-affluent and better-educated neighborhoods than the average U.S. resident. Among those who did register for courses, students with greater socioeconomic resources were more likely to earn a certificate. Furthermore, these differences in MOOC access and completion were larger for adolescents and young adults, the traditional ages where people find on-ramps into science, technology, engineering, and mathematics (STEM) coursework and careers. Our findings raise concerns that MOOCs and similar approaches to online learning can exacerbate rather than reduce disparities in educational outcomes related to socioeconomic status.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hansen, John D -- Reich, Justin -- New York, N.Y. -- Science. 2015 Dec 4;350(6265):1245-8. doi: 10.1126/science.aab3782. Epub 2015 Dec 3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Harvard Graduate School of Education, Harvard University, Cambridge, MA 02138, USA. john_hansen@mail.harvard.edu. ; Office of Digital Learning, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26785488" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Career Choice ; Certification/*methods ; Education, Distance/*methods ; Engineering/education ; Humans ; Internet ; Learning ; Mathematics/education ; *Online Systems ; Science/education ; *Social Class ; Students ; Technology/education ; United States ; Young Adult
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  • 75
    Publication Date: 2016-01-20
    Description: Mitochondrial morphology is shaped by fusion and division of their membranes. Here, we found that adult myocardial function depends on balanced mitochondrial fusion and fission, maintained by processing of the dynamin-like guanosine triphosphatase OPA1 by the mitochondrial peptidases YME1L and OMA1. Cardiac-specific ablation of Yme1l in mice activated OMA1 and accelerated OPA1 proteolysis, which triggered mitochondrial fragmentation and altered cardiac metabolism. This caused dilated cardiomyopathy and heart failure. Cardiac function and mitochondrial morphology were rescued by Oma1 deletion, which prevented OPA1 cleavage. Feeding mice a high-fat diet or ablating Yme1l in skeletal muscle restored cardiac metabolism and preserved heart function without suppressing mitochondrial fragmentation. Thus, unprocessed OPA1 is sufficient to maintain heart function, OMA1 is a critical regulator of cardiomyocyte survival, and mitochondrial morphology and cardiac metabolism are intimately linked.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wai, Timothy -- Garcia-Prieto, Jaime -- Baker, Michael J -- Merkwirth, Carsten -- Benit, Paule -- Rustin, Pierre -- Ruperez, Francisco Javier -- Barbas, Coral -- Ibanez, Borja -- Langer, Thomas -- New York, N.Y. -- Science. 2015 Dec 4;350(6265):aad0116. doi: 10.1126/science.aad0116.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Genetics, University of Cologne, 50674 Cologne, Germany. Max-Planck-Institute for Biology of Aging, Cologne, Germany. ; Myocardial Pathophysiology Area, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain. ; Institute for Genetics, University of Cologne, 50674 Cologne, Germany. ; INSERM UMR 1141, Hopital Robert Debre, Paris, France. Universite Paris 7, Faculte de Medecine Denis Diderot, Paris, France. ; Centre for Metabolomics and Bioanalysis (CEMBIO), Faculty of Pharmacy, Universidad San Pablo CEU, Campus Monteprincipe, Boadilla del Monte, 28668 Madrid, Spain. ; Myocardial Pathophysiology Area, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain. Department of Cardiology, Instituto de Investigacion Sanitaria (IIS), Fundacion Jimenez Diaz Hospital, Madrid, Spain. thomas.langer@uni-koeln.de bibanez@cnic.es. ; Institute for Genetics, University of Cologne, 50674 Cologne, Germany. Max-Planck-Institute for Biology of Aging, Cologne, Germany. Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany. Center for Molecular Medicine (CMMC), University of Cologne, Cologne, Germany. thomas.langer@uni-koeln.de bibanez@cnic.es.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26785494" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cardiomyopathy, Dilated/genetics/metabolism/pathology ; Diet, High-Fat ; Embryonic Development ; Female ; GTP Phosphohydrolases ; Gene Deletion ; Heart/embryology ; Heart Failure/genetics/*metabolism/pathology ; Male ; Metalloendopeptidases/genetics ; Metalloproteases/genetics/metabolism ; Mice ; Mice, Knockout ; Mitochondria, Heart/*metabolism/ultrastructure ; *Mitochondrial Degradation ; *Mitochondrial Dynamics ; Mitochondrial Proteins/genetics/metabolism ; Muscle, Skeletal/enzymology ; Myocardium/*metabolism/pathology ; Myocytes, Cardiac/enzymology/pathology ; Proteolysis
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  • 76
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2016-01-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gottlieb, Roberta A -- Bernstein, Daniel -- New York, N.Y. -- Science. 2015 Dec 4;350(6265):1162-3. doi: 10.1126/science.aad8222.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA. roberta.gottlieb@cshs.org. ; Department of Pediatrics, Stanford University, Palo Alto, CA 94304, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26785456" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Female ; Heart/*embryology ; Heart Failure/*metabolism ; Male ; Mitochondria, Heart/*metabolism/*physiology ; Mitochondrial Degradation/*physiology ; *Mitochondrial Dynamics ; Myocardium/*metabolism ; Ubiquitin-Protein Ligases/*metabolism
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  • 77
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2016-03-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schwartz, Gary J -- DK 020541/DK/NIDDK NIH HHS/ -- DK 026687/DK/NIDDK NIH HHS/ -- DK 105441/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 2016 Mar 18;351(6279):1268-9. doi: 10.1126/science.aaf5216. Epub 2016 Mar 17.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Departments of Medicine & Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA. gary.schwartz@einstein.yu.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26989239" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Energy Metabolism/*physiology ; Feeding Behavior/*physiology ; Hyperphagia/*genetics ; Male ; N-Acetylglucosaminyltransferases/*physiology ; Paraventricular Hypothalamic Nucleus/*physiology
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  • 78
    Publication Date: 2016-01-23
    Description: Mono-ubiquitination of Fancd2 is essential for repairing DNA interstrand cross-links (ICLs), but the underlying mechanisms are unclear. The Fan1 nuclease, also required for ICL repair, is recruited to ICLs by ubiquitinated (Ub) Fancd2. This could in principle explain how Ub-Fancd2 promotes ICL repair, but we show that recruitment of Fan1 by Ub-Fancd2 is dispensable for ICL repair. Instead, Fan1 recruitment--and activity--restrains DNA replication fork progression and prevents chromosome abnormalities from occurring when DNA replication forks stall, even in the absence of ICLs. Accordingly, Fan1 nuclease-defective knockin mice are cancer-prone. Moreover, we show that a Fan1 variant in high-risk pancreatic cancers abolishes recruitment by Ub-Fancd2 and causes genetic instability without affecting ICL repair. Therefore, Fan1 recruitment enables processing of stalled forks that is essential for genome stability and health.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770513/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770513/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lachaud, Christophe -- Moreno, Alberto -- Marchesi, Francesco -- Toth, Rachel -- Blow, J Julian -- Rouse, John -- WT096598MA/Wellcome Trust/United Kingdom -- Medical Research Council/United Kingdom -- New York, N.Y. -- Science. 2016 Feb 19;351(6275):846-9. doi: 10.1126/science.aad5634. Epub 2016 Jan 21.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Medical Research Council Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, Sir James Black Centre, University of Dundee, Dundee DD1 5EH, Scotland, UK. ; Centre for Gene Regulation and Expression, College of Life Sciences, Sir James Black Centre, University of Dundee, Dundee DD1 5EH, Scotland, UK. ; School of Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Bearsden Road, Glasgow G61 1QH, UK. ; Medical Research Council Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, Sir James Black Centre, University of Dundee, Dundee DD1 5EH, Scotland, UK. j.rouse@dundee.ac.uk.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26797144" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; *Chromosome Aberrations ; DNA Repair ; *DNA Replication ; Endodeoxyribonucleases/genetics/*metabolism ; Fanconi Anemia Complementation Group D2 Protein/genetics/*metabolism ; Female ; Gene Knock-In Techniques ; Genetic Predisposition to Disease ; Genomic Instability/*genetics ; Liver Neoplasms/genetics/pathology ; Lung Neoplasms/genetics/pathology ; Lymphoma/genetics/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Molecular Sequence Data ; Pancreatic Neoplasms/*genetics ; *Ubiquitination
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  • 79
    Publication Date: 2016-03-19
    Description: Maintaining energy homeostasis is crucial for the survival and health of organisms. The brain regulates feeding by responding to dietary factors and metabolic signals from peripheral organs. It is unclear how the brain interprets these signals. O-GlcNAc transferase (OGT) catalyzes the posttranslational modification of proteins by O-GlcNAc and is regulated by nutrient access. Here, we show that acute deletion of OGT from alphaCaMKII-positive neurons in adult mice caused obesity from overeating. The hyperphagia derived from the paraventricular nucleus (PVN) of the hypothalamus, where loss of OGT was associated with impaired satiety. These results identify O-GlcNAcylation in alphaCaMKII neurons of the PVN as an important molecular mechanism that regulates feeding behavior.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4817221/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4817221/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lagerlof, Olof -- Slocomb, Julia E -- Hong, Ingie -- Aponte, Yeka -- Blackshaw, Seth -- Hart, Gerald W -- Huganir, Richard L -- N01-HV-00240/HV/NHLBI NIH HHS/ -- P01 HL107153/HL/NHLBI NIH HHS/ -- P01HL107153/HL/NHLBI NIH HHS/ -- R01 DK061671/DK/NIDDK NIH HHS/ -- R01 NS036715/NS/NINDS NIH HHS/ -- R01DK6167/DK/NIDDK NIH HHS/ -- R01NS036715/NS/NINDS NIH HHS/ -- Intramural NIH HHS/ -- New York, N.Y. -- Science. 2016 Mar 18;351(6279):1293-6. doi: 10.1126/science.aad5494.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Solomon H. Snyder Department of Neuroscience, Kavli Neuroscience Discovery Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. ; National Institute on Drug Abuse + National Institutes of Health/Johns Hopkins University Graduate Partnership Program, Baltimore, MD 21224, USA. ; Solomon H. Snyder Department of Neuroscience, Kavli Neuroscience Discovery Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. ; Solomon H. Snyder Department of Neuroscience, Kavli Neuroscience Discovery Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Intramural Research Program, Neuronal Circuits and Behavior Unit, National Institute on Drug Abuse, Baltimore, MD 21224, USA. ; Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. ; Solomon H. Snyder Department of Neuroscience, Kavli Neuroscience Discovery Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. rhuganir@jhmi.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26989246" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylglucosamine/metabolism ; Animals ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/metabolism ; Energy Metabolism/genetics/*physiology ; Feeding Behavior/*physiology ; Gene Deletion ; Homeostasis/genetics ; Hyperphagia/*genetics ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; N-Acetylglucosaminyltransferases/genetics/*physiology ; Neurons/enzymology ; Obesity/genetics ; Paraventricular Hypothalamic Nucleus/cytology/enzymology/*physiology ; Protein Processing, Post-Translational ; Satiety Response/physiology
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  • 80
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2016-04-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Landolt, Hans-Peter -- Holst, Sebastian C -- New York, N.Y. -- Science. 2016 Apr 29;352(6285):517-8. doi: 10.1126/science.aaf8178.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland. Zurich Center for Interdisciplinary Sleep Research, University of Zurich, Zurich, Switzerland. landolt@pharma.uzh.ch. ; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland. Zurich Center for Interdisciplinary Sleep Research, University of Zurich, Zurich, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27126024" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cations/*metabolism ; Cerebral Cortex/*physiology ; Male ; Potassium/*metabolism ; Sleep/*physiology ; Wakefulness/*physiology
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  • 81
    Publication Date: 2016-02-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Claiborne, Anne B -- English, Rebecca A -- Kahn, Jeffrey P -- 10002265/PHS HHS/ -- New York, N.Y. -- Science. 2016 Feb 12;351(6274):668-70. doi: 10.1126/science.aaf3091. Epub 2016 Feb 3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Medicine, U.S. National Academies of Sciences, Engineering, and Medicine, Washington, DC 20001, USA. aclaiborne@nas.edu. ; Institute of Medicine, U.S. National Academies of Sciences, Engineering, and Medicine, Washington, DC 20001, USA. ; Johns Hopkins Berman Institute of Bioethics, Johns Hopkins University, Baltimore, MD 21205, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26842937" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Nucleus/genetics ; DNA, Mitochondrial/genetics ; Ethics, Medical ; *Government Regulation ; Humans ; Mitochondrial Diseases/genetics/*prevention & control ; Mitochondrial Replacement Therapy/*ethics/*standards ; *Oocytes ; United States ; United States Food and Drug Administration ; *Zygote
    Print ISSN: 0036-8075
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  • 82
    Publication Date: 2016-03-26
    Description: Shadlen et al's Comment focuses on extrapolations of our results that were not implied or asserted in our Report. They discuss alternate analyses of average firing rates in other tasks, the relationship between neural activity and behavior, and possible extensions of the standard models we examined. Although interesting to contemplate, these points are not germane to the findings of our Report: that stepping dynamics provided a better statistical description of lateral intraparietal area spike trains than diffusion-to-bound dynamics for a majority of neurons.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Latimer, Kenneth W -- Yates, Jacob L -- Meister, Miriam L R -- Huk, Alexander C -- Pillow, Jonathan W -- New York, N.Y. -- Science. 2016 Mar 25;351(6280):1406. doi: 10.1126/science.aad3596.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Perceptual Systems, The University of Texas at Austin, Austin, TX 78712, USA. Institute for Neuroscience, The University of Texas at Austin, Austin, TX 78712, USA. Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195, USA. ; Center for Perceptual Systems, The University of Texas at Austin, Austin, TX 78712, USA. Institute for Neuroscience, The University of Texas at Austin, Austin, TX 78712, USA. ; Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195, USA. ; Center for Perceptual Systems, The University of Texas at Austin, Austin, TX 78712, USA. Institute for Neuroscience, The University of Texas at Austin, Austin, TX 78712, USA. Department of Neuroscience, The University of Texas at Austin, Austin, TX 78712, USA. Department of Psychology, The University of Texas at Austin, Austin, TX 78712, USA. ; Center for Perceptual Systems, The University of Texas at Austin, Austin, TX 78712, USA. Institute for Neuroscience, The University of Texas at Austin, Austin, TX 78712, USA. Department of Psychology, The University of Texas at Austin, Austin, TX 78712, USA. Princeton Neuroscience Institute and Department of Psychology, Princeton University, Princeton, NJ 08544, USA. pillow@princeton.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27013724" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Choice Behavior/*physiology ; Decision Making/*physiology ; Male ; Parietal Lobe/*physiology
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  • 83
    Publication Date: 2016-03-26
    Description: Latimeret al (Reports, 10 July 2015, p. 184) claim that during perceptual decision formation, parietal neurons undergo one-time, discrete steps in firing rate instead of gradual changes that represent the accumulation of evidence. However, that conclusion rests on unsubstantiated assumptions about the time window of evidence accumulation, and their stepping model cannot explain existing data as effectively as evidence-accumulation models.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shadlen, Michael N -- Kiani, Roozbeh -- Newsome, William T -- Gold, Joshua I -- Wolpert, Daniel M -- Zylberberg, Ariel -- Ditterich, Jochen -- de Lafuente, Victor -- Yang, Tianming -- Roitman, Jamie -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2016 Mar 25;351(6280):1406. doi: 10.1126/science.aad3242.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute (HHMI) and Department of Neuroscience, Columbia University, New York, NY, USA. shadlen@columbia.edu. ; Center for Neural Science, New York University, New York, NY, USA. ; HHMI and Stanford University, Stanford, CA, USA. ; Department of Neuroscience, University of Pennsylvania, Philadelphia, PA, USA. ; Department of Engineering, University of Cambridge, Cambridge, UK. ; HHMI and Department of Neuroscience, Columbia University, New York, NY, USA. ; Center for Neuroscience and Department of Neurobiology, Physiology, and Behavior, University of California, Davis, CA, USA. ; Institute for Neuroscience, National Autonomous University of Mexico, Queretaro, Mexico. ; Institute of Neuroscience, Chinese Academy of Sciences, Shanghai, China. ; Department of Psychology, University of Illinois at Chicago, Chicago, IL, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27013723" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Choice Behavior/*physiology ; Decision Making/*physiology ; Male ; Parietal Lobe/*physiology
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  • 84
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2016-01-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, Jon -- New York, N.Y. -- Science. 2016 Jan 29;351(6272):434. doi: 10.1126/science.351.6272.434.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26823407" target="_blank"〉PubMed〈/a〉
    Keywords: Anti-Retroviral Agents/*pharmacokinetics/therapeutic use ; *Drug Resistance, Viral ; HIV/drug effects/*genetics/physiology ; HIV Infections/blood/*drug therapy/*virology ; Humans ; Lymph Nodes/*virology ; Male ; Mutagenesis ; RNA, Viral/analysis ; Tissue Distribution ; Virus Replication
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  • 85
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2016-01-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, Jon -- New York, N.Y. -- Science. 2016 Jan 1;351(6268):16-9. doi: 10.1126/science.351.6268.16.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26721985" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biomedical Research/*economics ; Communicable Disease Control/*economics ; Financial Management ; Humans ; National Institutes of Health (U.S.) ; United States ; Vaccines/*economics
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  • 86
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2016-01-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shanahan, Jesse -- New York, N.Y. -- Science. 2016 Jan 22;351(6271):418. doi: 10.1126/science.351.6271.418.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Jesse Shanahan is a master's student in astronomy at Wesleyan University in Middletown, Connecticut. Send your story to SciCareerEditor@aaas.org.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26798017" target="_blank"〉PubMed〈/a〉
    Keywords: Astronomy/*education ; *Career Mobility ; Disabled Persons/*psychology/statistics & numerical data ; Fear ; *Hostility ; Humans ; Male ; United States
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  • 87
    Publication Date: 2016-01-02
    Description: Several recent studies link parental environments to phenotypes in subsequent generations. In this work, we investigate the mechanism by which paternal diet affects offspring metabolism. Protein restriction in mice affects small RNA (sRNA) levels in mature sperm, with decreased let-7 levels and increased amounts of 5' fragments of glycine transfer RNAs (tRNAs). In testicular sperm, tRNA fragments are scarce but increase in abundance as sperm mature in the epididymis. Epididymosomes (vesicles that fuse with sperm during epididymal transit) carry RNA payloads matching those of mature sperm and can deliver RNAs to immature sperm in vitro. Functionally, tRNA-glycine-GCC fragments repress genes associated with the endogenous retroelement MERVL, in both embryonic stem cells and embryos. Our results shed light on sRNA biogenesis and its dietary regulation during posttesticular sperm maturation, and they also link tRNA fragments to regulation of endogenous retroelements active in the preimplantation embryo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sharma, Upasna -- Conine, Colin C -- Shea, Jeremy M -- Boskovic, Ana -- Derr, Alan G -- Bing, Xin Y -- Belleannee, Clemence -- Kucukural, Alper -- Serra, Ryan W -- Sun, Fengyun -- Song, Lina -- Carone, Benjamin R -- Ricci, Emiliano P -- Li, Xin Z -- Fauquier, Lucas -- Moore, Melissa J -- Sullivan, Robert -- Mello, Craig C -- Garber, Manuel -- Rando, Oliver J -- DP1ES025458/DP/NCCDPHP CDC HHS/ -- R01HD080224/HD/NICHD NIH HHS/ -- UL1 TR000161/TR/NCATS NIH HHS/ -- UL1 TR001453/TR/NCATS NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2016 Jan 22;351(6271):391-6. doi: 10.1126/science.aad6780. Epub 2015 Dec 31.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA. ; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA. Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA. ; Department of Obstetrics, Gynecology and Reproduction, Universite Laval, Centre Hospitalier Universitaire de Quebec Research Center, Quebec City, Quebec G1V 4G2, Canada. ; RNAi Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA 01605, USA. ; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA. RNAi Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA 01605, USA. ; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA. RNAi Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA 01605, USA. Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, MA 01605, USA. ; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA. RNAi Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA 01605, USA. Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, MA 01605, USA. ; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA. oliver.rando@umassmed.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26721685" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blastocyst/metabolism ; Diet, Protein-Restricted ; Epididymis/metabolism ; *Fertilization ; *Gene Expression Regulation ; Male ; Mice ; MicroRNAs/metabolism ; RNA, Transfer, Gly/*metabolism/*physiology ; Retroelements/genetics ; *Sperm Maturation ; Spermatozoa/*metabolism ; Testis/metabolism
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  • 88
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2016-01-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Leslie, Mitch -- New York, N.Y. -- Science. 2016 Jan 1;351(6268):13. doi: 10.1126/science.351.6268.13.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26721982" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; DNA/chemistry/genetics/metabolism ; *Epigenesis, Genetic ; Male ; Metabolism/*genetics ; Mice ; RNA, Transfer/genetics/*metabolism ; *Spermatozoa
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  • 89
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2016-01-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin-Frankel, Jennifer -- New York, N.Y. -- Science. 2016 Jan 29;351(6272):440-3. doi: 10.1126/science.351.6272.440.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26823410" target="_blank"〉PubMed〈/a〉
    Keywords: Child ; Child, Preschool ; DNA Mutational Analysis ; DNA Repair/genetics ; Female ; *Genes, Neoplasm ; *Genetic Predisposition to Disease ; Humans ; Male ; Mutation ; Neoplasms/*genetics/mortality ; Pedigree ; Tumor Suppressor Protein p53/genetics
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  • 90
    Publication Date: 2016-02-27
    Description: Ebola virus disease in humans is highly lethal, with case fatality rates ranging from 25 to 90%. There is no licensed treatment or vaccine against the virus, underscoring the need for efficacious countermeasures. We ascertained that a human survivor of the 1995 Kikwit Ebola virus disease outbreak maintained circulating antibodies against the Ebola virus surface glycoprotein for more than a decade after infection. From this survivor we isolated monoclonal antibodies (mAbs) that neutralize recent and previous outbreak variants of Ebola virus and mediate antibody-dependent cell-mediated cytotoxicity in vitro. Strikingly, monotherapy with mAb114 protected macaques when given as late as 5 days after challenge. Treatment with a single human mAb suggests that a simplified therapeutic strategy for human Ebola infection may be possible.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Corti, Davide -- Misasi, John -- Mulangu, Sabue -- Stanley, Daphne A -- Kanekiyo, Masaru -- Wollen, Suzanne -- Ploquin, Aurelie -- Doria-Rose, Nicole A -- Staupe, Ryan P -- Bailey, Michael -- Shi, Wei -- Choe, Misook -- Marcus, Hadar -- Thompson, Emily A -- Cagigi, Alberto -- Silacci, Chiara -- Fernandez-Rodriguez, Blanca -- Perez, Laurent -- Sallusto, Federica -- Vanzetta, Fabrizia -- Agatic, Gloria -- Cameroni, Elisabetta -- Kisalu, Neville -- Gordon, Ingelise -- Ledgerwood, Julie E -- Mascola, John R -- Graham, Barney S -- Muyembe-Tamfun, Jean-Jacques -- Trefry, John C -- Lanzavecchia, Antonio -- Sullivan, Nancy J -- Intramural NIH HHS/ -- New York, N.Y. -- Science. 2016 Mar 18;351(6279):1339-42. doi: 10.1126/science.aad5224. Epub 2016 Feb 25.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Research in Biomedicine, Universita della Svizzera Italiana, CH-6500 Bellinzona, Switzerland. Humabs BioMed SA, 6500 Bellinzona, Switzerland. ; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. ; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA. ; Institute for Research in Biomedicine, Universita della Svizzera Italiana, CH-6500 Bellinzona, Switzerland. ; Humabs BioMed SA, 6500 Bellinzona, Switzerland. ; National Institute for Biomedical Research, National Laboratory of Public Health, Kinshasa B.P. 1197, Democratic Republic of the Congo. ; Institute for Research in Biomedicine, Universita della Svizzera Italiana, CH-6500 Bellinzona, Switzerland. Institute of Microbiology, ETH Zurich, CH-8093 Zurich, Switzerland. ; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. njsull@mail.nih.gov.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26917593" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Animals ; Antibodies, Monoclonal/*administration & dosage/immunology/isolation & ; purification ; Antibodies, Neutralizing/*administration & dosage/immunology/isolation & ; purification ; Antibodies, Viral/*administration & dosage/immunology/isolation & purification ; Clinical Trials as Topic ; Disease Outbreaks ; Ebolavirus/*immunology ; Female ; Hemorrhagic Fever, Ebola/epidemiology/*prevention & control ; Humans ; Macaca ; Male ; Molecular Sequence Data ; Survivors
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  • 91
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2016-03-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin-Frankel, Jennifer -- New York, N.Y. -- Science. 2016 Mar 11;351(6278):1126. doi: 10.1126/science.351.6278.1126.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26965598" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cholesterol, HDL/*blood ; Coronary Disease/*blood/*genetics ; Female ; Humans ; Male ; Scavenger Receptors, Class B/*genetics
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  • 92
    Publication Date: 2016-01-02
    Description: CRISPR/Cas9-mediated genome editing holds clinical potential for treating genetic diseases, such as Duchenne muscular dystrophy (DMD), which is caused by mutations in the dystrophin gene. To correct DMD by skipping mutant dystrophin exons in postnatal muscle tissue in vivo, we used adeno-associated virus-9 (AAV9) to deliver gene-editing components to postnatal mdx mice, a model of DMD. Different modes of AAV9 delivery were systematically tested, including intraperitoneal at postnatal day 1 (P1), intramuscular at P12, and retro-orbital at P18. Each of these methods restored dystrophin protein expression in cardiac and skeletal muscle to varying degrees, and expression increased from 3 to 12 weeks after injection. Postnatal gene editing also enhanced skeletal muscle function, as measured by grip strength tests 4 weeks after injection. This method provides a potential means of correcting mutations responsible for DMD and other monogenic disorders after birth.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760628/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760628/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Long, Chengzu -- Amoasii, Leonela -- Mireault, Alex A -- McAnally, John R -- Li, Hui -- Sanchez-Ortiz, Efrain -- Bhattacharyya, Samadrita -- Shelton, John M -- Bassel-Duby, Rhonda -- Olson, Eric N -- DK-099653/DK/NIDDK NIH HHS/ -- HL-077439/HL/NHLBI NIH HHS/ -- HL-093039/HL/NHLBI NIH HHS/ -- HL-111665/HL/NHLBI NIH HHS/ -- R01 DK099653/DK/NIDDK NIH HHS/ -- R01 HL077439/HL/NHLBI NIH HHS/ -- R01 HL093039/HL/NHLBI NIH HHS/ -- R01 HL111665/HL/NHLBI NIH HHS/ -- U01 HL100401/HL/NHLBI NIH HHS/ -- U01-HL-100401/HL/NHLBI NIH HHS/ -- U54 HD 087351/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 2016 Jan 22;351(6271):400-3. doi: 10.1126/science.aad5725. Epub 2015 Dec 31.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Sen. Paul D. Wellstone Muscular Dystrophy Cooperative Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. ; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. ; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Sen. Paul D. Wellstone Muscular Dystrophy Cooperative Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. eric.olson@utsouthwestern.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26721683" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *CRISPR-Cas Systems ; Dependovirus ; Disease Models, Animal ; Dystrophin/*genetics ; Exons/genetics ; Female ; Forelimb/physiopathology ; Genetic Therapy/*methods ; Genome/genetics ; Hand Strength ; Male ; Mice ; Mice, Inbred mdx ; Muscle, Skeletal/metabolism ; Muscular Dystrophy, Duchenne/genetics/*therapy ; Myocardium/metabolism
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  • 93
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2016-02-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stevens, Beth -- Muthukumar, Allie K -- New York, N.Y. -- Science. 2016 Feb 19;351(6275):813. doi: 10.1126/science.aaf2849.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurology, F. M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA 02115, USA. beth.stevens@childrens.harvard.edu. ; Department of Neurology, F. M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26912878" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Astrocytes/*metabolism ; Cerebellar Cortex/*cytology ; Female ; Hedgehog Proteins/*metabolism ; Male ; Neurons/*metabolism ; Receptors, G-Protein-Coupled/*metabolism
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  • 94
    Publication Date: 2016-04-02
    Description: Global climate change is a major threat to biodiversity. Large-scale analyses have generally focused on the impacts of climate change on the geographic ranges of species and on phenology, the timing of ecological phenomena. We used long-term monitoring of the abundance of breeding birds across Europe and the United States to produce, for both regions, composite population indices for two groups of species: those for which climate suitability has been either improving or declining since 1980. The ratio of these composite indices, the climate impact indicator (CII), reflects the divergent fates of species favored or disadvantaged by climate change. The trend in CII is positive and similar in the two regions. On both continents, interspecific and spatial variation in population abundance trends are well predicted by climate suitability trends.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stephens, Philip A -- Mason, Lucy R -- Green, Rhys E -- Gregory, Richard D -- Sauer, John R -- Alison, Jamie -- Aunins, Ainars -- Brotons, Lluis -- Butchart, Stuart H M -- Campedelli, Tommaso -- Chodkiewicz, Tomasz -- Chylarecki, Przemyslaw -- Crowe, Olivia -- Elts, Jaanus -- Escandell, Virginia -- Foppen, Ruud P B -- Heldbjerg, Henning -- Herrando, Sergi -- Husby, Magne -- Jiguet, Frederic -- Lehikoinen, Aleksi -- Lindstrom, Ake -- Noble, David G -- Paquet, Jean-Yves -- Reif, Jiri -- Sattler, Thomas -- Szep, Tibor -- Teufelbauer, Norbert -- Trautmann, Sven -- van Strien, Arco J -- van Turnhout, Chris A M -- Vorisek, Petr -- Willis, Stephen G -- New York, N.Y. -- Science. 2016 Apr 1;352(6281):84-7. doi: 10.1126/science.aac4858.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Conservation Ecology Group, School of Biological and Biomedical Sciences, Durham University, South Road, Durham DH1 3LE, UK. ; Royal Society for the Protection of Birds, Centre for Conservation Science, The Lodge, Sandy, Bedfordshire SG19 2DL, UK. ; Royal Society for the Protection of Birds, Centre for Conservation Science, The Lodge, Sandy, Bedfordshire SG19 2DL, UK. Conservation Science Group, Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK. ; United States Geological Survey, Patuxent Wildlife Research Center, 12100 Beech Forest Road, Laurel, MD 20708, USA. ; Institute of Integrative Biology, University of Liverpool, Crown Street, Liverpool L69 3BX, UK. ; Faculty of Biology, University of Latvia, Jelgavas iela 1, Riga, LV-1004, Latvia. ; Center for Mediterranean Forest Research, Centre Tecnologic Forestal de Catalunya, InForest JRU, Solsona 25280, Spain. REAF, Cerdanyola del Valles 08193, Catalonia, Spain. CSIC, Cerdanyola del Valles 08193, Catalonia, Spain. ; Conservation Science Group, Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK. BirdLife International, The David Attenborough Building, Pembroke Street, Cambridge CB2 3QZ, UK. ; MITO2000 National Committee; c/o Dream Italia, Via Garibaldi 3, 52015, Pratovecchio-Stia, Arezzo, Italy. ; Ogolnopolskie Towarzystwo Ochrony Ptakow, Odrowaza 24,05-270 Marki, Poland. ; Museum and Institute of Zoology, Polish Academy of Sciences, Wilcza 64, 00-679 Warszawa, Poland. ; BirdWatch Ireland, Unit 20 Block D Bullford Business Campus, Kilcoole, County Wicklow, Ireland. ; Institute of Ecology and Earth Sciences, University of Tartu, Vanemuise Street 46, 51014 Tartu, Estonia. Estonian Ornithological Society, Veski 4, 51005 Tartu, Estonia. ; Sociedad Espanola de Ornitologia/BirdLife Melquiades Biencinto, 34, 28053 Madrid. Spain. ; European Bird Census Council, Post Office Box 6521, 6503 GA Nijmegen, Netherlands. Sovon Dutch Centre for Field Ornithology, Post Office Box 6521, 6503 GA Nijmegen, Netherlands. Department of Animal Ecology and Ecophysiology, Institute for Water and Wetland Research, Radboud University, Post Office Box 9010, 6500 GL Nijmegen, Netherlands. ; Dansk Ornitologisk Forening-BirdLife Denmark and University of Aarhus, Vesterbrogade 140, 1620 Kobenhavn V, Denmark. ; European Bird Census Council-Catalan Ornithological Institute, Natural History Museum of Barcelona, Placa Leonardo da Vinci 4-5, 08019 Barcelona, Catalonia, Spain. ; Section for Science, Nord University, 7600 Levanger, Norway. ; UMR7204 Sorbonne Universites-MNHN-CNRS-UPMC, CESCO, CRBPO, CP 135, 43 Rue Buffon, 75005 Paris, France. ; The Helsinki Lab of Ornithology, Finnish Museum of Natural History, Post Office Box 17, 00014 University of Helsinki, Finland. ; Biodiversity Unit, Department of Biology, Lund University, Ecology Building, S-223 62 Lund, Sweden. ; The British Trust for Ornithology, The Nunnery, Thetford, Norfolk IP24 2PU, UK. ; Natagora, Departement Etudes, Rue Nanon 98, B-5000 Namur, Belgium. ; Institute for Environmental Studies, Faculty of Science, Charles University in Prague, Czech Republic. Department of Zoology and Laboratory of Ornithology, Faculty of Science, Palacky University Olomouc, 17 Listopadu 50, 771 43 Olomouc, Czech Republic. ; Swiss Ornithological Institute, Seerose 1, 6204 Sempach, Switzerland. ; Institute of Environmental Sciences, University of Nyiregyhaza, Sostoi ut 31/b, 4400 Nyiregyhaza, Hungary. ; BirdLife Austria, Museumsplatz 1/10/8, A-1070 Vienna, Austria. ; Dachverband Deutscher Avifaunisten e.V. (Federation of German Avifaunists), An den Speichern 6, D-48157 Munster, Germany. ; Statistics Netherlands, Post Office Box 24500, 2490 HA The Hague, Netherlands. ; Sovon Dutch Centre for Field Ornithology, Post Office Box 6521, 6503 GA Nijmegen, Netherlands. Department of Animal Ecology and Ecophysiology, Institute for Water and Wetland Research, Radboud University, Post Office Box 9010, 6500 GL Nijmegen, Netherlands. ; Department of Zoology and Laboratory of Ornithology, Faculty of Science, Palacky University Olomouc, 17 Listopadu 50, 771 43 Olomouc, Czech Republic. Pan-European Common Bird Monitoring Scheme, Czech Society for Ornithology, Na Belidle 252/34, CZ-15000 Prague 5, Czech Republic.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27034371" target="_blank"〉PubMed〈/a〉
    Keywords: Animal Migration ; Animals ; Biodiversity ; *Birds ; Breeding ; *Climate Change ; Ecological Parameter Monitoring ; Europe ; Population Dynamics ; United States
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  • 95
    Publication Date: 2016-03-19
    Description: Sanchez et al.'s textbook k-anonymization example does not prove, or even suggest, that location and other big-data data sets can be anonymized and of general use. The synthetic data set that they "successfully anonymize" bears no resemblance to modern high-dimensional data sets on which their methods fail. Moving forward, deidentification should not be considered a useful basis for policy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉de Montjoye, Yves-Alexandre -- Pentland, Alex Sandy -- New York, N.Y. -- Science. 2016 Mar 18;351(6279):1274. doi: 10.1126/science.aaf1578.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Harvard University, Institute for Quantitative Social Science, Cambridge, MA 02138, USA. yvesalexandre@demontjoye.com. ; Massachusetts Institute of Technology, Cambridge, MA 02139, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26989244" target="_blank"〉PubMed〈/a〉
    Keywords: *Commerce ; *Data Collection ; Female ; Humans ; *Information Dissemination ; Male ; *Privacy
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  • 96
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2016-03-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stone, Richard -- New York, N.Y. -- Science. 2016 Mar 11;351(6278):1138-40. doi: 10.1126/science.351.6278.1138.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26965605" target="_blank"〉PubMed〈/a〉
    Keywords: Computer Simulation ; *Explosions ; *Forensic Sciences ; Humans ; *Nuclear Weapons ; United States
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  • 97
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2016-01-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Devkota, Suzanne -- New York, N.Y. -- Science. 2016 Jan 29;351(6272):452-3. doi: 10.1126/science.aaf1353.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA. suzanne.devkota@cshs.org.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26823414" target="_blank"〉PubMed〈/a〉
    Keywords: Diabetes Mellitus, Type 2/*microbiology ; Female ; Gastrointestinal Microbiome/*drug effects/*physiology ; Humans ; Male ; Metformin/*pharmacology
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  • 98
    Publication Date: 2016-04-30
    Description: Wakefulness is driven by the widespread release of neuromodulators by the ascending arousal system. Yet, it is unclear how these substances orchestrate state-dependent, global changes in neuronal activity. Here, we show that neuromodulators induce increases in the extracellular K(+) concentration ([K(+)]e) in cortical slices electrically silenced by tetrodotoxin. In vivo, arousal was linked to AMPA receptor-independent elevations of [K(+)]e concomitant with decreases in [Ca(2+)]e, [Mg(2+)]e, [H(+)]e, and the extracellular volume. Opposite, natural sleep and anesthesia reduced [K(+)]e while increasing [Ca(2+)]e, [Mg(2+)]e, and [H(+)]e as well as the extracellular volume. Local cortical activity of sleeping mice could be readily converted to the stereotypical electroencephalography pattern of wakefulness by simply imposing a change in the extracellular ion composition. Thus, extracellular ions control the state-dependent patterns of neural activity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ding, Fengfei -- O'Donnell, John -- Xu, Qiwu -- Kang, Ning -- Goldman, Nanna -- Nedergaard, Maiken -- NS078167/NS/NINDS NIH HHS/ -- NS078304/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2016 Apr 29;352(6285):550-5. doi: 10.1126/science.aad4821.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY 14642, USA. Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. ; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY 14642, USA. ; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY 14642, USA. Center for Basic and Translational Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2200, Denmark. nedergaard@urmc.rochester.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27126038" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Calcium/analysis/metabolism ; Cations/analysis/*metabolism ; Cerebral Cortex/chemistry/drug effects/*physiology ; Electroencephalography ; Magnesium/analysis/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Neurons/drug effects/metabolism/physiology ; Neurotransmitter Agents/metabolism/pharmacology ; Potassium/*metabolism ; Receptors, AMPA/metabolism ; Sleep/drug effects/*physiology ; Sodium Channel Blockers/pharmacology ; Tetrodotoxin/pharmacology ; Wakefulness/drug effects/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 99
    Publication Date: 2016-03-05
    Description: During corticogenesis, excitatory neurons are born from progenitors located in the ventricular zone (VZ), from where they migrate to assemble into circuits. How neuronal identity is dynamically specified upon progenitor division is unknown. Here, we study this process using a high-temporal-resolution technology allowing fluorescent tagging of isochronic cohorts of newborn VZ cells. By combining this in vivo approach with single-cell transcriptomics in mice, we identify and functionally characterize neuron-specific primordial transcriptional programs as they dynamically unfold. Our results reveal early transcriptional waves that instruct the sequence and pace of neuronal differentiation events, guiding newborn neurons toward their final fate, and contribute to a road map for the reverse engineering of specific classes of cortical neurons from undifferentiated cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Telley, Ludovic -- Govindan, Subashika -- Prados, Julien -- Stevant, Isabelle -- Nef, Serge -- Dermitzakis, Emmanouil -- Dayer, Alexandre -- Jabaudon, Denis -- New York, N.Y. -- Science. 2016 Mar 25;351(6280):1443-6. doi: 10.1126/science.aad8361. Epub 2016 Mar 3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Basic Neurosciences, University of Geneva, Switzerland. Institute for Genetics and Genomics in Geneva (iGE3), University of Geneva, Switzerland. ; Department of Genetic Medicine and Development, University of Geneva, Switzerland. Institute for Genetics and Genomics in Geneva (iGE3), University of Geneva, Switzerland. ; Department of Genetic Medicine and Development, University of Geneva, Switzerland. Biomedical Research Foundation Academy of Athens, Greece. Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Saudi Arabia. Institute for Genetics and Genomics in Geneva (iGE3), University of Geneva, Switzerland. ; Department of Basic Neurosciences, University of Geneva, Switzerland. Department of Psychiatry, Geneva University Hospital, Switzerland. Institute for Genetics and Genomics in Geneva (iGE3), University of Geneva, Switzerland. ; Department of Basic Neurosciences, University of Geneva, Switzerland. Clinic of Neurology, Geneva University Hospital, Switzerland. Institute for Genetics and Genomics in Geneva (iGE3), University of Geneva, Switzerland. denis.jabaudon@unige.ch.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26940868" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Cerebral Ventricles/cytology/embryology ; DNA-Binding Proteins/genetics ; Female ; GPI-Linked Proteins/genetics ; Green Fluorescent Proteins/genetics ; Male ; Mice ; Neocortex/cytology/*embryology ; Nerve Tissue Proteins/genetics ; Neural Stem Cells/cytology ; Neurogenesis/*genetics ; Neurons/*cytology ; Neuropeptides/genetics ; SOXB1 Transcription Factors/genetics ; *Transcription, Genetic ; Transcriptome
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 100
    Publication Date: 2016-03-05
    Description: As tumors grow, they acquire mutations, some of which create neoantigens that influence the response of patients to immune checkpoint inhibitors. We explored the impact of neoantigen intratumor heterogeneity (ITH) on antitumor immunity. Through integrated analysis of ITH and neoantigen burden, we demonstrate a relationship between clonal neoantigen burden and overall survival in primary lung adenocarcinomas. CD8(+)tumor-infiltrating lymphocytes reactive to clonal neoantigens were identified in early-stage non-small cell lung cancer and expressed high levels of PD-1. Sensitivity to PD-1 and CTLA-4 blockade in patients with advanced NSCLC and melanoma was enhanced in tumors enriched for clonal neoantigens. T cells recognizing clonal neoantigens were detectable in patients with durable clinical benefit. Cytotoxic chemotherapy-induced subclonal neoantigens, contributing to an increased mutational load, were enriched in certain poor responders. These data suggest that neoantigen heterogeneity may influence immune surveillance and support therapeutic developments targeting clonal neoantigens.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McGranahan, Nicholas -- Furness, Andrew J S -- Rosenthal, Rachel -- Ramskov, Sofie -- Lyngaa, Rikke -- Saini, Sunil Kumar -- Jamal-Hanjani, Mariam -- Wilson, Gareth A -- Birkbak, Nicolai J -- Hiley, Crispin T -- Watkins, Thomas B K -- Shafi, Seema -- Murugaesu, Nirupa -- Mitter, Richard -- Akarca, Ayse U -- Linares, Joseph -- Marafioti, Teresa -- Henry, Jake Y -- Van Allen, Eliezer M -- Miao, Diana -- Schilling, Bastian -- Schadendorf, Dirk -- Garraway, Levi A -- Makarov, Vladimir -- Rizvi, Naiyer A -- Snyder, Alexandra -- Hellmann, Matthew D -- Merghoub, Taha -- Wolchok, Jedd D -- Shukla, Sachet A -- Wu, Catherine J -- Peggs, Karl S -- Chan, Timothy A -- Hadrup, Sine R -- Quezada, Sergio A -- Swanton, Charles -- 12100/Cancer Research UK/United Kingdom -- 1R01CA155010-02/CA/NCI NIH HHS/ -- 1R01CA182461-01/CA/NCI NIH HHS/ -- 1R01CA184922-01/CA/NCI NIH HHS/ -- Cancer Research UK/United Kingdom -- New York, N.Y. -- Science. 2016 Mar 25;351(6280):1463-9. doi: 10.1126/science.aaf1490. Epub 2016 Mar 3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉The Francis Crick Institute, London WC2A 3LY, UK. Centre for Mathematics and Physics in the Life Sciences and Experimental Biology (CoMPLEX), University College London (UCL), London WC1E 6BT, UK. Cancer Research UK Lung Cancer Centre of Excellence, UCL Cancer Institute, London WC1E 6BT, UK. ; Cancer Research UK Lung Cancer Centre of Excellence, UCL Cancer Institute, London WC1E 6BT, UK. Cancer Immunology Unit, UCL Cancer Institute, UCL, London WC1E 6BT, UK. ; Cancer Research UK Lung Cancer Centre of Excellence, UCL Cancer Institute, London WC1E 6BT, UK. ; Section for Immunology and Vaccinology, National Veterinary Institute, Technical University of Denmark, 1970 Frederiksberg C, Denmark. ; The Francis Crick Institute, London WC2A 3LY, UK. Cancer Research UK Lung Cancer Centre of Excellence, UCL Cancer Institute, London WC1E 6BT, UK. ; The Francis Crick Institute, London WC2A 3LY, UK. ; Cancer Immunology Unit, UCL Cancer Institute, UCL, London WC1E 6BT, UK. Department of Cellular Pathology, UCL, London WC1E 6BT, UK. ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA. Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Center for Cancer Precision Medicine, Dana-Farber Cancer Institute, Boston, MA 02215, USA. ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA. Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. ; Department of Dermatology, University Hospital, University Duisburg-Essen, 45147 Essen, Germany. German Cancer Consortium (DKTK), 69121 Heidelberg, Germany. ; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. ; Hematology/Oncology Division, 177 Fort Washington Avenue, Columbia University, New York, NY 10032, USA. ; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Weill Cornell Medical College, New York, NY 10065, USA. ; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Ludwig Collaborative Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. ; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Weill Cornell Medical College, New York, NY 10065, USA. Ludwig Collaborative Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA. Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Department of Medicine, Harvard Medical School, Boston, MA 02115, USA. Department of Internal Medicine, Brigham and Woman's Hospital, Boston, MA 02115, USA. ; Cancer Research UK Lung Cancer Centre of Excellence, UCL Cancer Institute, London WC1E 6BT, UK. Cancer Immunology Unit, UCL Cancer Institute, UCL, London WC1E 6BT, UK. s.quezada@ucl.ac.uk charles.swanton@crick.ac.uk. ; The Francis Crick Institute, London WC2A 3LY, UK. Cancer Research UK Lung Cancer Centre of Excellence, UCL Cancer Institute, London WC1E 6BT, UK. s.quezada@ucl.ac.uk charles.swanton@crick.ac.uk.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26940869" target="_blank"〉PubMed〈/a〉
    Keywords: Adenocarcinoma/drug therapy/genetics/*immunology ; Aged ; Aged, 80 and over ; Antigens, Neoplasm/genetics/*immunology ; Antineoplastic Agents/therapeutic use ; CD4-Positive T-Lymphocytes/*immunology ; CTLA-4 Antigen/immunology ; Carcinoma, Non-Small-Cell Lung/genetics/immunology ; Cell Cycle Checkpoints/immunology ; Female ; Humans ; *Immunologic Surveillance ; Lung Neoplasms/drug therapy/genetics/*immunology ; Lymphocytes, Tumor-Infiltrating/immunology ; Male ; Melanoma/immunology ; Middle Aged ; Mutation ; Programmed Cell Death 1 Receptor/immunology ; Skin Neoplasms/immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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