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  • Base Sequence
  • American Association for the Advancement of Science (AAAS)  (25)
  • American Association of Petroleum Geologists (AAPG)
  • 1975-1979  (25)
Collection
Keywords
Publisher
  • American Association for the Advancement of Science (AAAS)  (25)
  • American Association of Petroleum Geologists (AAPG)
Years
Year
  • 1
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    Regulation of gene expression: possible role of repetitive sequences (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-06-08
    Description: Large contrasts are observed between the messenger RNA populations of different tissues and of embryos at different stages of development. Nevertheless, coding sequences for genes not expressed in a cell appear to be present in its nuclear RNA. Though many nuclear RNA transcripts of single copy DNA sequences are held in common between tissues, an additional set, probably consisting of non-message sequences, is not shared. Nuclear RNA also contains transcripts of repetitive DNA sequences. Certain repeat families are represented at high levels in the nuclear RNA of particular tissues and much lower levels in others. It is surprising that both complements of most repeat sequences are present in nuclear RNA. These observations lead to model for regulation of gene expression in which the formation of repetitive RNA-RNA duplexes controls the production of messenger RNA.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Davidson, E H -- Britten, R J -- New York, N.Y. -- Science. 1979 Jun 8;204(4397):1052-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451548" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Cell Nucleus/physiology ; DNA/*genetics ; Genes ; *Genes, Regulator ; Hydrogen Bonding ; Mammals/embryology ; Models, Biological ; Polyribosomes/metabolism ; *RNA, Heterogeneous Nuclear/genetics ; RNA, Messenger/genetics ; Sea Urchins/embryology ; *Transcription, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
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    Viroids: structure and function (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-31
    Description: Viroids are nucleic acid species of relatively low molecular weight and unique structure that cause several important diseases of cultivated plants. Similar nucleic acid species may be responsible for certain diseases of animals and humans. Viroids are the smallest known agents of infectious disease. Unlike viral nucleic acids, viroids are not encapsidated. Despite their small size, viroids replicate autonomously in cells of susceptible plant species. Known viroids are single-stranded, covalently closed circular, as well as linear, RNA molecules with extensive regions of intramolecular complementarity; they exist in their native state as highly base-paired rods.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Diener, T O -- New York, N.Y. -- Science. 1979 Aug 31;205(4409):859-66.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472709" target="_blank"〉PubMed〈/a〉
    Keywords: Base Sequence ; DNA, Viral/genetics ; Molecular Weight ; Nucleic Acid Conformation ; Plant Viruses/*genetics/isolation & purification/ultrastructure ; RNA, Viral/*genetics ; Templates, Genetic ; Virus Replication
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  • 3
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    Total synthesis of a gene (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-02-16
    Description: The method developed for the total synthesis of a given DNA containing biologically specific sequences consists of the following. The DNA in the double-stranded form is carefully divided into short single-stranded segments with suitable overlaps in the complementary strands. All the segments are chemically synthesized starting with protected nucleosides and mononucleotides. The 5'-OH ends of the appropriate oligonucleotides are then phosphorylated with the use of [y-32P]ATP and polynucleotide kinase. A few to several neighboring oligonucleotides are then allowed to form bihelical complexes in aqueous solution, and the latter are joined end to end by polynucleotide ligase to form covalently linked duplexes. Subsequent heat-to-tail joining of the short duplexes leads to the total DNA. The methods are described for the construction of a biologically functional suppressor transfer RNA gene. The total work involved (i) the synthesis of a 126-nucleotide-long bihelical DNA corresponding to a known precursor to the tyrosine suppressor transfer RNA, (ii) the sequencing of the promoter region and the distal region adjoining the C-C-A end, which contained a signal for the processing of the RNA transcript, (iii) total synthesis of the 207 base-pair-long DNA, which included the control elements, as well as the Eco R1 restriction endonuclease specific sequences at the two ends, and (iv) full characterization by transcription in vitro and amber suppressor activity in vivo of the synthetic gene.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Khorana, H G -- New York, N.Y. -- Science. 1979 Feb 16;203(4381):614-25.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/366749" target="_blank"〉PubMed〈/a〉
    Keywords: Base Sequence ; DNA, Recombinant ; DNA-Directed RNA Polymerases/metabolism ; Escherichia coli/genetics ; *Genes ; Genes, Regulator ; Hydrogen Bonding ; Nucleic Acid Conformation ; Oligodeoxyribonucleotides/*chemical synthesis ; Oligonucleotides/*chemical synthesis ; RNA, Transfer/*genetics ; Suppression, Genetic ; Transcription, Genetic ; Tyrosine
    Print ISSN: 0036-8075
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  • 4
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    DNA organization of Methanobacterium thermoautotrophicum (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-06-08
    Description: The organism Methanobacterium thermoautotrophicum, an archaebacterium, is envolutionarily very distant from both traditional prokaryotes and eukaryotes. Its genome (DNA) has physical characteristics typical of most prokaryotes except that it is quite small (about 10(9) daltons, less than half the size of the genome of Escherichia coli) and contains a significant amount (6 percent) DNA which renatures extremely rapidly.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mitchell, R M -- Loeblich, L A -- Klotz, L C -- Loeblich, A R 3rd -- New York, N.Y. -- Science. 1979 Jun 8;204(4397):1082-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/377486" target="_blank"〉PubMed〈/a〉
    Keywords: Base Sequence ; Biological Evolution ; DNA, Bacterial/*genetics ; Escherichia coli/genetics ; Euryarchaeota/classification/*genetics ; Nucleic Acid Renaturation
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  • 5
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    Structure of the constant and 3' untranslated regions of the murine gamma 2b heavy chain messenger RNA (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-14
    Description: The complete coding sequence for the constant region of the mouse gamma 2b immunoglobulin heavy chain and the 3' untranslated region has been determined. The coding portion of the sequence is 1008 nucleotides long (amino acid residues 114 to 449), and the 3' noncoding region contains 102 nucleotides preceeding the polyadenylate. An extra carboxyl-terminal lysine residue which had not been observed in the gamma 2b or other gamma subclass protein sequences occurs in the nucleotide sequence and is probably processed posttranslationally. A 17-nucleotide sequence occurs with slight variation twice in CH1 and once in CH2 domains in the same relative location but with different translational phase. This sequence may be the site of crossover in a gamma 2b . gamma 2a heavy chain variant, an indication of possible recombinational activity of some kind.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tucker, P W -- Marcu, K B -- Slightom, J L -- Blattner, F R -- New York, N.Y. -- Science. 1979 Dec 14;206(4424):1299-303.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/117548" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Biological Evolution ; Codon ; DNA, Recombinant ; Immunoglobulin Constant Regions/*genetics ; Immunoglobulin Heavy Chains/*genetics ; Immunoglobulin gamma-Chains/*genetics ; Immunoglobulins/*genetics ; Mice ; *Protein Biosynthesis ; RNA, Messenger/*genetics
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  • 6
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    beta-Galactosidase and selective neutrality (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-03-09
    Description: Three hypotheses to explain the amino acid composition of proteins are inconsistent (P congruent to 10(-9) with the experimental data for beta-galactosidase from Escherichia coli. The exceptional length of this protein, 1021 residues, permits rigorous tests of these hypotheses without complication from statistical artifacts. Either this protein is not at compositional equilibrium, which is unlikely from knowledge about other proteins, or the evolution of this protein and its coding gene have not been selectively neutral. However, the composition of approximately 60 percent of the molecule is consistent with either a selectively neutral or nonneutral evolutionary process.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holmquist, R -- New York, N.Y. -- Science. 1979 Mar 9;203(4384):1012-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/106468" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Amino Acids/analysis ; Base Sequence ; Biological Evolution ; Escherichia coli/enzymology ; Galactosidases/*genetics ; Genes ; Genetic Code ; *Selection, Genetic ; beta-Galactosidase/analysis/*genetics
    Print ISSN: 0036-8075
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  • 7
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    Restriction endonucleases, simian virus 40, and the new genetics (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nathans, D -- New York, N.Y. -- Science. 1979 Nov 23;206(4421):903-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/228393" target="_blank"〉PubMed〈/a〉
    Keywords: Antigens, Viral/genetics ; Base Sequence ; Chromosome Mapping ; DNA Replication ; DNA Restriction Enzymes/*metabolism ; DNA, Viral/genetics ; Genes ; Genes, Regulator ; Genetics/*trends ; Nobel Prize ; Simian virus 40/*genetics ; Virus Replication
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    Comparison of total sequence of a cloned rabbit beta-globin gene and its flanking regions with a homologous mouse sequence (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-10-19
    Description: The nucleotide sequence of a cloned rabbit chromosomal DNA segment of 1620 nucleotides length which contains a beta-globin gene is presented. The coding regions are separated into three blocks by two intervening sequences of 126 and 573 base pairs, respectively. The rabbit sequence was compared with a homologous mouse sequence. The segments flanking the rabbit gene, as well as the coding regions, the 5' noncoding and part of the 3' noncoding messenger RNA sequences are similar to those of the mouse gene; the homologous introns, despite identical location, are distinctly dissimilar except for the junction regions. Homologous introns may be derived from common ancestral introns by large insertions and deletions rather than be multiple point mutations.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉van Ooyen, A -- van den Berg, J -- Mantei, N -- Weissmann, C -- New York, N.Y. -- Science. 1979 Oct 19;206(4416):337-44.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/482942" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Biological Evolution ; Codon ; DNA, Recombinant ; Genetic Linkage ; Globins/*genetics ; Mice/*genetics ; Rabbits/*genetics
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  • 9
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    Sequence of the cloned gene for the constant region of murine gamma 2b immunoglobulin heavy chain (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-14
    Description: The complete nucleotide sequence of the gamma 2b constant region gene cloned from BALB/c liver DNA is reported. The sequence of approximately 1870 base pairs includes the 5' flanking, 3' untranslated, and 3' flanking regions and three introns. The C gamma 2b coding region is divided by these introns into four segments corresponding to the homology domains and hinge region of the protein. The introns separating the hinge from the CH2 domain and the CH2 from the CH3 domain are small (106 and 119 base pairs). A larger intervening sequence of 314 base pairs separates the CH1 and hinge regions. The stretch of DNA comprising this large intron plus the hinge shows a strong homology with the other CH domains.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tucker, P W -- Marcu, K B -- Newell, N -- Richards, J -- Blattner, F R -- New York, N.Y. -- Science. 1979 Dec 14;206(4424):1303-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/117549" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Biological Evolution ; DNA, Recombinant ; *Genes ; Immunoglobulin Constant Regions/*genetics ; Immunoglobulin Heavy Chains/*genetics ; Immunoglobulin gamma-Chains/*genetics ; Immunoglobulins/*genetics ; Liver ; Mice ; Mice, Inbred BALB C ; Nucleic Acid Precursors/genetics ; RNA, Messenger/genetics ; Transcription, Genetic
    Print ISSN: 0036-8075
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  • 10
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    BK virus DNA: complete nucleotide sequence of a human tumor virus (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-10-26
    Description: The complete DNA sequence of the human papovavirus BK is presented. From the 4963 base-pair sequence of BK virus (MM strain), the amino acid sequence of at least five proteins can be deduced: a T antigen and a t antigen, which share amino terminal peptides; proteins VP2 and VP3, which share 232 amino acids; and protein VP1, whose coding sequence overlaps those for VP2 and VP3 by 113 nucleotides but is read in a different frame. The gene loci and the arrangement of genes are strikingly similar in BK virus and simian virus 40 (SV40). The sequence of the deduced proteins in BK virus shares 73 percent amino acid homology with those in SV40, whereas the DNA sequence of the two viruses shares 70 percent homology, suggesting close evolutionary relationship. However, the repeated DNA sequences in the noncoding regions of these viruses are different.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yang, R C -- Wu, R -- New York, N.Y. -- Science. 1979 Oct 26;206(4417):456-62.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/228391" target="_blank"〉PubMed〈/a〉
    Keywords: Antigens, Viral/genetics ; BK Virus/*genetics ; Base Sequence ; Codon ; DNA, Viral/*genetics ; Genes ; Genes, Regulator ; Polyomavirus/*genetics ; Simian virus 40/genetics ; Viral Proteins/genetics
    Print ISSN: 0036-8075
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  • 11
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    Evolutionary relatedness of viper and primate endogenous retroviruses (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-04-20
    Description: A retrovirus previously isolated from a tumored Russell's viper is shown by molecular hybridization to be an endogenous virus of this reptilian species. Radio-immunologic techniques revealed that the viper retrovirus is immunologically and, hence, evolutionarily related to endogenous type D retorviruses of Old World primates. These findings extend the number of vertebrate classes possessing endogenous retroviruses and suggest that type D retroviruses may even be more widely distributed in nature than type C retroviruses.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Andersen, P R -- Barbacid, M -- Tronick, S R -- Clark, H F -- Aaronson, S A -- New York, N.Y. -- Science. 1979 Apr 20;204(4390):318-21.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/219480" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigens, Viral/analysis ; Base Sequence ; *Biological Evolution ; *Genes, Viral ; Nucleic Acid Hybridization ; Primates/*microbiology ; Retroviridae/*genetics/immunology ; Snakes/genetics/*microbiology ; Viral Proteins/immunology
    Print ISSN: 0036-8075
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  • 12
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    Nuclear transcripts of mouse heavy chain immunoglobulin genes contain only the expressed class of C-region sequences (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-06-08
    Description: In plasmacytoma cells producing IgG, IgA, or IgM immunoglobulin heavy chains, the large precursors of the heavy chain messenger RNA's contain nucleotide sequences that specify only the expressed class of constant region. This indicates that the switch from one class of heavy chain to another during B cell ontogeny does not occur by altered processing of a complex gene transcript.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marcu, K B -- Schibler, U -- Perry, R P -- New York, N.Y. -- Science. 1979 Jun 8;204(4397):1087-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/109919" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Cell Line ; Cell Nucleus/metabolism ; Immunoglobulin Constant Regions/*genetics ; Immunoglobulin Heavy Chains/*genetics ; Immunoglobulins/*genetics ; Mice ; Myeloma Proteins/*genetics ; Neoplasms, Experimental/immunology ; Nucleic Acid Precursors/genetics ; Plasmacytoma/immunology ; Poly A/metabolism ; RNA, Heterogeneous Nuclear/genetics ; *Transcription, Genetic
    Print ISSN: 0036-8075
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  • 13
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    Simultaneous production of Q and R bands after staining with chromomycin A3 or olivomycin (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-04-06
    Description: Human and mouse chromosomes, stained with either chromomycin A3 or olivomycin, which bind preferentially to G - C-rich DNA (where G is guanosine and C is cytosine), exhibit a Q or a reverse banding pattern, depending on the wavelength used for excitation. The two complementary banding patterns can be observed in the same metaphase simply by changing the combination of excitation filters. These data suggest, therefore, that in addition to base composition, other factors are involved in the production of chromosome banding by chromomycin A3 and olivomycin.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Prantera, G -- Bonaccorsi, S -- Pimpinelli, S -- New York, N.Y. -- Science. 1979 Apr 6;204(4388):79-80.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/86207" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Cells, Cultured ; Centromere/ultrastructure ; *Chromomycins ; Chromosomes/*ultrastructure ; *Dna ; Fluorescent Dyes ; Humans ; Mice ; *Olivomycins ; Staining and Labeling
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  • 14
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    Periodicity of deoxyribonuclease I digestion of chromatin (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-05-25
    Description: Two methods have been used to measure the single-strand lengths of the DNA fragments produced by deoxyribonuclease I digestion of chromatin. The average lengths obtained are muliples of about 10.4 bases, significantly different from the value of 10 previously reported. This periodicity in fragment lengths is closely related to the periodicity of the DNA double helix in chromatin, but the two values need not be exactly the same.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Prunell, A -- Kornberg, R D -- Lutter, L -- Klug, A -- Levitt, M -- Crick, F H -- New York, N.Y. -- Science. 1979 May 25;204(4395):855-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/441739" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Chromatin/metabolism/*ultrastructure ; Deoxyribonucleases/*metabolism ; Hydrolysis ; Molecular Weight ; Rats
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  • 15
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    Split genes and RNA splicing (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-04-20
    Description: A number of genes in higher organisms and in their viruses appear to be split. That is, they have "nonsense" stretches of DNA interspersed within the sense DNA. The cell produces a full RNA transcript of this DNA, nonsense and all, and then appears to splice out the nonsense sequences before sending the RNA to the cytoplasm. In this article what is known about these intervening sequences and about the processing of the RNA is outlined. Also discussed is their possible use and how they might have arisen in evolution.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Crick, F -- New York, N.Y. -- Science. 1979 Apr 20;204(4390):264-71.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/373120" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Biological Evolution ; DNA/genetics ; Endonucleases/metabolism ; Eukaryotic Cells/physiology ; *Genes ; Nucleic Acid Precursors/*genetics ; RNA Ligase (ATP)/metabolism ; RNA, Heterogeneous Nuclear/*genetics ; RNA, Messenger/*genetics ; RNA, Ribosomal/genetics ; RNA, Transfer/genetics ; *Transcription, Genetic
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  • 16
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    Protein and nucleic acid sequence data and phylogeny (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Demoulin, V -- New York, N.Y. -- Science. 1979 Sep 7;205(4410):1036-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472727" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Base Sequence ; Cytochromes/genetics ; Ferredoxins/genetics ; *Phylogeny ; Proteins/*genetics ; RNA, Ribosomal/*genetics
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  • 17
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    Human growth hormone: complementary DNA cloning and expression in bacteria (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-10
    Description: The nucleotide sequence of a DNA complementary to human growth hormone messenger RNA was cloned; it contains 29 nucleotides in its 5' untranslated region, the 651 nucleotides coding for the prehormone, and the entire 3' untranslated region (108 nucleotides). The data reported predict the previously unknown sequence of the signal peptide of human growth hormone and, by comparison with the previously determined sequences of rat growth hormone and human chorionic somatomammotropin, strengthens the hypothesis that these genes evolved by gene duplication from a common ancestral sequence. The human growth hormone gene sequences have been linked in phase to a fragment of the trp D gene of Escherichia coli in a plasmid vehicle, and a fusion protein is synthesized at high level (approximately 3 percent of bacterial protein) under the control of the regulatory region of the trp operon. This fusion protein (70 percent of whose amino acids are coded for by the human growth hormone gene) reacts specifically with antibodies to human growth hormone and is stable in E. coli.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Martial, J A -- Hallewell, R A -- Baxter, J D -- Goodman, H M -- New York, N.Y. -- Science. 1979 Aug 10;205(4406):602-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/377496" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Base Sequence ; Cattle ; DNA, Recombinant/*metabolism ; Escherichia coli/*metabolism ; Growth Hormone/*biosynthesis ; Humans ; Pituitary Gland/metabolism ; Pituitary Neoplasms/metabolism ; *Plasmids ; Poly A/metabolism ; Prolactin/biosynthesis ; *Protein Biosynthesis ; RNA, Messenger/metabolism ; *Transcription, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 18
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    The genome of simian virus 40 (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-05-05
    Description: The nucleotide sequence of SV40 DNA was determined, and the sequence was correlated with known genes of the virus and with the structure of viral messenger RNA's. There is a limited overlap of the coding regions for structural proteins and a complex pattern of leader sequences at the 5' end of late messenger RNA. The sequence of the early region is consistent with recent proposals that the large early polypeptide of SV40 is encoded in noncontinguous segments of DNA.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Reddy, V B -- Thimmappaya, B -- Dhar, R -- Subramanian, K N -- Zain, B S -- Pan, J -- Ghosh, P K -- Celma, M L -- Weissman, S M -- New York, N.Y. -- Science. 1978 May 5;200(4341):494-502.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/205947" target="_blank"〉PubMed〈/a〉
    Keywords: Base Sequence ; Chromosome Mapping ; Codon ; DNA Replication ; DNA, Circular ; DNA, Viral ; Genes ; *Genes, Viral ; Simian virus 40/*genetics ; Transcription, Genetic ; Viral Proteins/genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 19
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    Origins of prokaryotes, eukaryotes, mitochondria, and chloroplasts (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-01-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schwartz, R M -- Dayhoff, M O -- New York, N.Y. -- Science. 1978 Jan 27;199(4327):395-403.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/202030" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Base Sequence ; *Biological Evolution ; *Cells ; *Chloroplasts ; Computers ; Cytochrome c Group ; *Eukaryotic Cells ; Ferredoxins ; *Mitochondria ; Nucleic Acids ; *Prokaryotic Cells ; Proteins ; RNA, Ribosomal
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 20
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    Antibody diversity (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-10-06
    Description: Three important aspects of immunoglobulin gene organization and structure have emerged from studies of cloned immunoglobulin kappa chain genes. (i) Multiple variable genes are encoded separately in the genome of both immunoglobulin-producing and uncommitted (embryonic) cells, thereby establishing the evolutionary base for generating immunoglobulin diversity. (ii) These genes exist as many small, closely related families (subgroups) that share close sequence homology largely within their own subgroup. (iii) Comparison of two cloned variable gene segments derived from a single subgroup reveals a feature of their structure that distinguishes them from fixed genes (that is, globin genes) and provides, through extensive surrounding sequence homology, a large target for intergenic recombination. This last observation suggests that a simple recombination mechanism may account for their genetic instability in both germ line and somatic cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Seidman, J G -- Leder, A -- Nau, M -- Norman, B -- Leder, P -- New York, N.Y. -- Science. 1978 Oct 6;202(4363):11-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/99815" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Antibody Specificity ; Base Sequence ; Binding Sites, Antibody/*genetics ; Biological Evolution ; Cell Line ; Embryo, Mammalian/immunology ; *Genes ; Immunoglobulin Constant Regions/*genetics ; Immunoglobulin Light Chains/*genetics ; Immunoglobulin Variable Region/*genetics ; Immunoglobulin kappa-Chains/*genetics ; Immunoglobulins/*genetics ; Mice ; Neoplasms, Experimental/immunology ; Plasmacytoma/immunology ; Recombination, Genetic
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 21
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    Implications of RNA-RNA splicing in evolution of eukaryotic cells (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-12-22
    Description: The differences in the biochemistry of messenger RNA formation in eukaryotes compared to prokaryotes are so profound as to suggest that sequential prokaryotic to eukaryotic cell evolution seems unlikely. The recently discovered noncontiguous sequences in eukaryotic DNA that encode messenger RNA may reflect an ancient, rather than a new, distribution of information in DNA and that eukaryotes evolved independently of prokaryotes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Darnell, J E Jr -- New York, N.Y. -- Science. 1978 Dec 22;202(4374):1257-60.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/364651" target="_blank"〉PubMed〈/a〉
    Keywords: Adenoviruses, Human/genetics ; Base Sequence ; *Biological Evolution ; Eukaryotic Cells/physiology ; *Genes ; Prokaryotic Cells/physiology ; RNA, Messenger/*genetics ; RNA, Transfer/genetics ; RNA, Viral/genetics ; Recombination, Genetic ; Saccharomyces cerevisiae/genetics ; Transcription, Genetic
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 22
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    The 1978 Nobel prize in physiology or medicine (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-12-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Linn, S -- New York, N.Y. -- Science. 1978 Dec 8;202(4372):1069-71.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/362532" target="_blank"〉PubMed〈/a〉
    Keywords: *Awards and Prizes ; Base Sequence ; *DNA Restriction Enzymes/history/metabolism ; DNA, Recombinant ; Genetic Engineering ; History, 20th Century ; R Factors ; Substrate Specificity
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 23
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    Highly reiterated sequences of SIMIANSIMIANSIMIANSIMIANSIMIAN (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-04-28
    Description: A 172-base pair segment of DNA that is repeated several million times in the genome of the African green monkey has been characterized. Sequence analysis revealed that the many repeats of this complex unit are not all identical but represent a set of closely related segments: Sequence divergence occurs at various positions in the segment in a nonrandom manner. The uncloned segment obtained from monkey DNA is compared with a cloned segment of the same DNA which was recombined into the genome of simian virus 40 during permissive infection.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rosenberg, H -- Singer, M -- Rosenberg, M -- New York, N.Y. -- Science. 1978 Apr 28;200(4340):394-402.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/205944" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Biological Evolution ; Cell Line ; Cercopithecus/*genetics ; Cercopithecus aethiops/*genetics ; DNA/*genetics ; DNA Restriction Enzymes ; DNA, Recombinant ; Haplorhini ; Molecular Weight ; Recombination, Genetic ; Simian virus 40/genetics
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 24
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    Low repetitive DNA content in Aspergillus nidulans (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-12-01
    Description: DNA-DNA reassociation experiments show that the genome of Aspergillus nidulans consists of approximately 97 to 98 percent unique and 2 to 3 percent reiterated sequences. The reiterated DNA sequences have a complexity of about 11,000 base pairs and are repeated approximately 60 times per haploid genome. Ribosomal RNA-DNA hybridization experiments indicate that most of the repetitive DNA codes for ribosomal RNA.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Timberlake, W E -- New York, N.Y. -- Science. 1978 Dec 1;202(4371):973-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/362530" target="_blank"〉PubMed〈/a〉
    Keywords: Aspergillus nidulans/*genetics ; Base Sequence ; DNA/*genetics ; Genes ; Genes, Regulator ; Nucleic Acid Hybridization ; Nucleic Acid Renaturation
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 25
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    Cloning human fetal gamma globin and mouse alpha-type globin DNA: characterization and partial sequencing (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-12-22
    Description: Two globin-related clones isolated from collections of bacteriophages containing unfractionated Eco RI fragments of human and mouse DNA were characterized. Charon3AHs51.1Hbgamma includes 2.7 kilobase pairs of human DNA containing a large part of a fetal gamma globin chain structural gene; Charon 3AMm30.5 includes 4.7 kilobase pairs of mouse DNA related to alpha globin. The human fetal gamma globin gene has within its coding region two intervening sequences of noncoding DNA, IVS 1 and IVS 2, of approximately 1-0 and 900 base pairs. Sequence IVS 1 is located at the position of one of the two intervening sequences occurring in adult globin genes; IVS 2 is located at the position of the other.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smithies, O -- Blechl, A E -- Denniston-Thompson, K -- Newell, N -- Richards, J E -- Slightom, J L -- Tucker, P W -- Blattner, F R -- New York, N.Y. -- Science. 1978 Dec 22;202(4374):1284-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/725604" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Base Sequence ; Codon ; DNA Restriction Enzymes/metabolism ; DNA, Recombinant ; Fetal Hemoglobin/*genetics ; *Genes ; Globins/*genetics ; Humans ; Methods ; Mice ; Nucleic Acid Hybridization ; RNA, Messenger/genetics
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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