ALBERT — All Library Books, journals and Electronic Records Telegrafenberg

1

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The impact of faulting complexity and type on earthquake rupture dynamics (2022)

Zaccagnino, Davide ; Doglioni, Carlo

Nature Publishing Group

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Publikationsdatum: 2022-10-31

Beschreibung: The statistical properties of seismicity are known to be affected by several factors such as the rheological parameters of rocks. We analysed the earthquake double-couple as a function of the faulting type. Here we show that it impacts the moment tensors of earthquakes: thrust- faulting events are characterized by higher double-couple components with respect to strike- slip- and normal-faulting earthquakes. Our results are coherent with the stress dependence of the scaling exponent of the Gutenberg-Richter law, which is anticorrelated to the double- couple. We suggest that the structural and tectonic control of seismicity may have its origin in the complexity of the seismogenic source marked by the width of the cataclastic damage zone and by the slip of different fault planes during the same seismic event; the sharper and concentrated the slip as along faults, the higher the double-couple. This phenomenon may introduce bias in magnitude estimation, with possible impact on seismic forecasting.

Beschreibung: Published

Beschreibung: 258

Beschreibung: 2T. Deformazione crostale attiva

Beschreibung: JCR Journal

Schlagwort(e): double couple ; damage zone ; different fault type ; seismicity ; tectonics ; fault type ; seismicity ; 04.06. Seismology

Repository-Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)

Materialart: article

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2

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Arctic glaciers record wavier circumpolar winds (2022)

Sasgen, Ingo ; Salles, Annette ; Wegmann, Martin ; [weitere]

Nature Publishing Group

In: EPIC3Nature Climate Change, Nature Publishing Group, 12(3), pp. 249-255

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Publikationsdatum: 2022-06-20

Repository-Name: EPIC Alfred Wegener Institut

Materialart: Article , isiRev

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3

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Non-syntrophic methanogenic hydrocarbon degradation by an archaeal species (2022)

Zhou, Zhuo ; Zhang, Cui-jing ; Liu, Peng-fei ; [weitere]

Nature Publishing Group

In: EPIC3Nature, Nature Publishing Group, 601(7892), pp. 257-262

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Publikationsdatum: 2022-08-11

Beschreibung: The methanogenic degradation of oil hydrocarbons can proceed through syntrophic partnerships of hydrocarbon-degrading bacteria and methanogenic archaea1,2,3. However, recent culture-independent studies have suggested that the archaeon ‘Candidatus Methanoliparum’ alone can combine the degradation of long-chain alkanes with methanogenesis4,5. Here we cultured Ca. Methanoliparum from a subsurface oil reservoir. Molecular analyses revealed that Ca. Methanoliparum contains and overexpresses genes encoding alkyl-coenzyme M reductases and methyl-coenzyme M reductases, the marker genes for archaeal multicarbon alkane and methane metabolism. Incubation experiments with different substrates and mass spectrometric detection of coenzyme-M-bound intermediates confirm that Ca. Methanoliparum thrives not only on a variety of long-chain alkanes, but also on n-alkylcyclohexanes and n-alkylbenzenes with long n-alkyl (C≥13) moieties. By contrast, short-chain alkanes (such as ethane to octane) or aromatics with short alkyl chains (C≤12) were not consumed. The wide distribution of Ca. Methanoliparum4,5,6 in oil-rich environments indicates that this alkylotrophic methanogen may have a crucial role in the transformation of hydrocarbons into methane.

Repository-Name: EPIC Alfred Wegener Institut

Materialart: Article , NonPeerReviewed

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4

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Small sinking particles control anammox rates in the Peruvian oxygen minimum zone (2021)

Karthäuser, Clarissa ; Ahmerkamp, Soeren ; Marchant, Hannah K. ; [weitere]

Nature Publishing Group

In: EPIC3Nature Communications, Nature Publishing Group, 12(1), pp. 1-12

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Publikationsdatum: 2022-08-15

Beschreibung: Anaerobic oxidation of ammonium (anammox) in oxygen minimum zones (OMZs) is a major pathway of oceanic nitrogen loss. Ammonium released from sinking particles has been suggested to fuel this process. During cruises to the Peruvian OMZ in April–June 2017 we found that anammox rates are strongly correlated with the volume of small particles (128–512 µm), even though anammox bacteria were not directly associated with particles. This suggests that the relationship between anammox rates and particles is related to the ammonium released from particles by remineralization. To investigate this, ammonium release from particles was modelled and theoretical encounters of free-living anammox bacteria with ammonium in the particle boundary layer were calculated. These results indicated that small sinking particles could be responsible for ~75% of ammonium release in anoxic waters and that free-living anammox bacteria frequently encounter ammonium in the vicinity of smaller particles. This indicates a so far underestimated role of abundant, slow-sinking small particles in controlling oceanic nutrient budgets, and furthermore implies that observations of the volume of small particles could be used to estimate N-loss across large areas.

Repository-Name: EPIC Alfred Wegener Institut

Materialart: Article , NonPeerReviewed

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5

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Return to rapid ice loss in Greenland and record loss in 2019 detected by the GRACE-FO satellites (2020)

Sasgen, Ingo ; Wouters, Bert ; Gardner, Alex S ; [weitere]

Nature Publishing Group

In: EPIC3Communications Earth & Environment, Nature Publishing Group, 1(1), pp. 1-8

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Publikationsdatum: 2022-06-20

Beschreibung: Between 2003-2016, the Greenland ice sheet (GrIS) was one of the largest contributors to sea level rise, as it lost about 255 Gt of ice per year. This mass loss slowed in 2017 and 2018 to about 100 Gt yr−1. Here we examine further changes in rate of GrIS mass loss, by analyzing data from the GRACE-FO (Gravity Recovery and Climate Experiment – Follow On) satellite mission, launched in May 2018. Using simulations with regional climate models we show that the mass losses observed in 2017 and 2018 by the GRACE and GRACE-FO missions are lower than in any other two year period between 2003 and 2019, the combined period of the two missions. We find that this reduced ice loss results from two anomalous cold summers in western Greenland, compounded by snow-rich autumn and winter conditions in the east. For 2019, GRACE-FO reveals a return to high melt rates leading to a mass loss of 223 ± 12 Gt month−1 during the month of July alone, and a record annual mass loss of 532 ± 58 Gt yr−1.

Repository-Name: EPIC Alfred Wegener Institut

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6

Digitale Medien

Structural evidence for dimerization-regulated activation of an integral membrane phospholipase (1999)

Snijder, H. J. ; Ubarretxena-Belandia, I. ; Blaauw, M. ; [weitere]

[s.l.] : Nature Publishing Group

Nature 401 (1999), S. 717-721

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ISSN: 1476-4687

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik

Notizen: [Auszug] Dimerization is a biological regulatory mechanism employed by both soluble and membrane proteins. However, there are few structural data on the factors that govern dimerization of membrane proteins. Outer membrane phospholipase A (OMPLA) is an integral membrane enzyme which participates in ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/44890

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7

Digitale Medien

Emerging insights into the genesis of epilepsy (1999)

McNamara, James O.

[s.l.] : Nature Publishing Group

Nature 399.1999, Supplementary, A15-, (8 S.)

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ISSN: 1476-4687

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik

Notizen: [Auszug] Epilepsy, a brain disorder that is characterized by recurrent seizures, refers to a collection of disorders that affect 1–2% of the population worldwide. A seizure is a brief change in behaviour caused by the disordered, synchronous and rhythmic firing of populations of neurons in the ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/399a015

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8

Digitale Medien

Translating cell biology into therapeutic advances in Alzheimer's disease (1999)

Selkoe, Dennis J.

[s.l.] : Nature Publishing Group

Nature 399.1999, Supplementary, A23-, (9 S.)

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ISSN: 1476-4687

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik

Notizen: [Auszug] Studies of the molecular basis of Alzheimer's disease exemplify the increasingly blurred distinction between basic and applied biomedical research.The four genes so far implicated in familial Alzheimer's disease have each been shown to elevate brain levels of the self-aggregating amyloid-β ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/399a023

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9

Digitale Medien

Prospects for new restorative and neuroprotective treatments in Parkinson's disease (1999)

Dunnett, Stephen B. ; Björklund, Anders

[s.l.] : Nature Publishing Group

Nature 399.1999, Supplementary, A32-, (8 S.)

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ISSN: 1476-4687

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik

Notizen: [Auszug] Parkinson's disease (PD) is one of the major neurodegenerative disorders of middle and old age, and was originally described by James Parkinson in 1817. It is characterized by a trio of cardinal symptoms—muscle rigidity, tremor and bradykinesia—but can also involve postural deficits and ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/399a032

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10

Digitale Medien

Progress in determining the causes and treatment of multiple sclerosis (1999)

Noseworthy, John H.

[s.l.] : Nature Publishing Group

Nature 399.1999, Supplementary, A40-, (8 S.)

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ISSN: 1476-4687

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik

Notizen: [Auszug] The cause of multiple sclerosis remains unknown after more than a century of study. Unconfirmed work has once more indicated that a viral infection may be important in the aetiology of the disease, and there is considerable evidence for an important genetic influence on disease susceptibility. The ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/399a040

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11

Digitale Medien

Stability offers unique opportunity for research (1999)

[s.l.] : Nature Publishing Group

Nature 398 (1999), S. 4-5

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ISSN: 1476-4687

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik

Notizen: [Auszug] On 13 January this year, Brazil suffered a shock which, if you listen to some commentators abroad, shook it to its very core. In São Paulo the following week, however, the locals were unfazed. By Latin American standards, a devaluation of 25 per cent (later 45 per cent) is not much to get ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/19795

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12

Digitale Medien

Scientists seek support from Mexican public (1999)

[s.l.] : Nature Publishing Group

Nature 398 (1999), S. 7-9

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ISSN: 1476-4687

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik

Notizen: [Auszug] ...Last year, Luis Herrera-Estrella thought he saw an opportunity to use his science to contribute to Mexico's economy. Herrera-Estrella, a plant biotechnologist at the Centre for Research and Advanced Studies of the National Polytechnic Institute (CINVESTAV), was one of several scientists invited ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/18754

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13

Digitale Medien

Customs delays drive researchers to smuggling (1999)

[s.l.] : Nature Publishing Group

Nature 398 (1999), S. 10-10

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ISSN: 1476-4687

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik

Notizen: [Auszug] Even for those fortunate scientists in Latin America who manage to obtain adequate funding, have bright graduate students to work with and fast Internet links connecting them to the world of science, a major obstacle remains on the road to first-rate research: fast access to equipment and ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/18763

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14

Digitale Medien

Centre fights fixation with basic research (1999)

[s.l.] : Nature Publishing Group

Nature 398 (1999), S. 9-20

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ISSN: 1476-4687

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik

Notizen: [Auszug] The challenge of combining high-quality basic research with a mission to address the country's wider needs is embodied in the experience of UNAM's Nitrogen Fixation Research Centre, in Cuernavaca. The centre was founded in 1980 with the aim of studying the molecular basis of biological nitrogen ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/18760

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15

Digitale Medien

Chile tries to bridge gap in scientific standards (1999)

[s.l.] : Nature Publishing Group

Nature 398 (1999), S. 11-12

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ISSN: 1476-4687

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik

Notizen: [Auszug] ...Whichever way you look at it — by the reputation of its leading researchers abroad or the orderliness of its universities, by the amount its government spends on science or the number of papers its researchers publish each year in international journals — Chile's small scientific ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/18766

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16

Digitale Medien

Andes observatories belatedly take root (1999)

[s.l.] : Nature Publishing Group

Nature 398 (1999), S. 13-13

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ISSN: 1476-4687

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik

Notizen: [Auszug] ...Many astronomers regard Chile as the best place on Earth for astronomy. A stroll at night outside the dome at the Cerro Tololo Inter-American Observatory (CTIO) near La Serena in northern Chile reveals why. The sky is crystal clear, and so still that stable images of stars are a near certainty. ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/18774

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17

Digitale Medien

Community split on Peronist reform effort (1999)

[s.l.] : Nature Publishing Group

Nature 398 (1999), S. 14-15

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ISSN: 1476-4687

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik

Notizen: [Auszug] ...After a hectic day fighting to save his country from currency contagion — it's Monday on the week after the Brazilian réal collapsed, and speculators have the Argentinian peso in their sights — the Argentinian chef de cabinet, Jorge Rodríguez, is relaxed and relieved to ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/18778

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18

Digitale Medien

Collapse of réal sharpens Brazil's contrasts (1999)

[s.l.] : Nature Publishing Group

Nature 398 (1999), S. 16-18

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ISSN: 1476-4687

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik

Notizen: [Auszug] ...One of the least welcome tasks facing researchers at the Federal University of Rio de Janeiro — the second largest research university in Brazil — is to review grant applications from their colleagues 300 miles inland in São Paulo. “They ask for money for ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/18785

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19

Digitale Medien

Brazil's space programme comes of age (1999)

[s.l.] : Nature Publishing Group

Nature 398 (1999), S. 19-19

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ISSN: 1476-4687

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik

Notizen: [Auszug] ...This year, if schedules hold, Brazil will finally realize its 20-year ambition to join the first rank of spacefaring nations. The agenda for 1999 has all the ingredients of a mature space programme, from the debut of a new Brazilian rocket to the selection of astronauts to fly on the ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/18791

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20

Digitale Medien

Resources lacking to save Amazon biodiversity (1999)

[s.l.] : Nature Publishing Group

Nature 398 (1999), S. 20-21

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ISSN: 1476-4687

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik

Notizen: [Auszug] ...The people of the Amazon basin are among the poorest of South America, but the region's rainforests are home to the richest diversity of life in the world. The potential of that wealth for the region was recognized implicitly for the first time in 1992, when representatives of 150 nations ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/18795

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21

Digitale Medien

Cuban biotechnology treads a lonely path (1999)

[s.l.] : Nature Publishing Group

Nature 398 (1999), S. 22-23

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ISSN: 1476-4687

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik

Notizen: [Auszug] ...“Cuba's future must, by necessity, be a future of scientists,” Fidel Castro declared in 1960, soon after the Cuban revolution. Almost 40 years later, his prophesy is some way from fulfilment. But in one area of applied science — biotechnology — a concerted national effort ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/18799

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22

Digitale Medien

The changing landscape of ischaemic brain injury mechanisms (1999)

Lee, Jin-Moo ; Zipfel, Gregory J. ; Choi, Dennis W.

[s.l.] : Nature Publishing Group

Nature 399.1999, Supplementary, A7-, (8 S.)

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ISSN: 1476-4687

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik

Notizen: [Auszug] There is growing optimism among researchers in the field of brain ischaemia, as human stroke has at last become treatable and current research efforts delineate several new, potential therapies. Most strokes are caused by acute interruption of the brain arterial blood supply by a thrombus, leading ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/399a007

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23

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Oceanography: All change in the Arctic (1999)

Dickson, Bob

Nature Publishing Group

In: Nature, 397 (6718). pp. 389-391.

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Publikationsdatum: 2015-07-16

Materialart: Article , PeerReviewed

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24

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Increased El Niño frequency in a climate model forced by future greenhouse warming (1999)

Timmermann, A. ; Oberhuber, J. ; Bacher, A. ; [weitere]

Nature Publishing Group

In: Nature, 398 (6729). pp. 694-697.

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Publikationsdatum: 2021-02-25

Beschreibung: The El Niño/Southern Oscillation (ENSO) phenomenon is the strongest natural interannual climate fluctuation1. ENSO originates in the tropical Pacific Ocean and has large effects on the ecology of the region, but it also influences the entire global climate system and affects the societies and economies of manycountries2. ENSO can be understood as an irregular low-frequency oscillation between a warm (El Niño) and a cold (La Niña) state. The strong El Niños of 1982/1983 and 1997/1998, along with the more frequent occurrences of El Niños during the past few decades, raise the question of whether human-induced 'greenhouse' warming affects, or will affect, ENSO3. Several global climate models have been applied to transient greenhouse-gas-induced warming simulations to address this question4, 6, but the results have been debated owing to the inability of the models to fully simulate ENSO (because of their coarse equatorial resolution)7. Here we present results from a global climate model with sufficient resolution in the tropics to adequately represent the narrow equatorial upwelling and low-frequency waves. When the model is forced by a realistic future scenario of increasing greenhouse-gas concentrations, more frequent El-Niño-like conditions and stronger cold events in the tropical Pacific Ocean result

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25

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Ecology: Competition and coexistence (1999)

Sommer, Ulrich

Nature Publishing Group

In: Nature, 402 . pp. 366-367.

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Publikationsdatum: 2017-02-28

Materialart: Article , PeerReviewed

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26

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Possible predictability in overflow from the Denmark Strait (1999)

Dickson, B. ; Meincke, Jens ; Vassle, I. ; [weitere]

Nature Publishing Group

In: Nature, 397 . pp. 243-246.

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Publikationsdatum: 2017-02-28

Beschreibung: The overflow and descent of cold dense water from the Denmark Strait sill-a submarine passage between Greenland and Iceland-is a principal means by which the deep ocean is ventilated, and is an important element in the global thermohaline circulation. Previous investigations of its variability-in particular, direct current measurements(1,2) in the overflow core since 1986-have shown surprisingly little evidence of long-term changes in now speed. Here we report significant changes in the overflow characteristics during the winter of 1996-97, measured using two current-meter moorings and an inverted echo sounder located at different depths in the fastest part of the now. The overflow warmed to the highest monthly value yet recorded (2.4 degrees C), and showed a pronounced slowing and thinning at its lower margin. We believe that the extreme warmth of the overflow caused it to run higher on the continental slope off east Greenland, so that the lower current meters and the echo sounder were temporarily outside and deeper than the fast-flowing core; model simulations appear to confirm this interpretation, We suggest that the extreme warmth of the overflow is a lagged response to a warming upstream in the Fram Strait three years earlier (caused by an exceptional amplification of the winter North Atlantic Oscillation). If this is so, over-now characteristics may be predictable.

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27

Digitale Medien

Taking issue with UK funding priorities (1998)

Kealey, Terence

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 2-2

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] To the editor—I was dismayed by Bridget Ogilvie's statement in her recent Commentary1 that “the trend in [British] government support for the civil science base has been downwards for the last decade”. Twice last year I explained to her privately that this was a ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0198-002a

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Reply to “Taking issue with UK funding priorities” (1998)

Ogilvie, Bridget

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 2-2

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Ogilvie replies—Dr. Kealey appears to have misunderstood my point. A glance at the latest government statistics4 shows how government funding of civil R&D breaks down into three main components: (1) the Research Councils (2) the Higher Education Funding Councils (HEFC's) and (3) civil ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0198-002b

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Lead and caries (1998)

Baum, Carl R. ; Shannon, Michael W.

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 3-3

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] To the editor—We read with interest the recent report by Watson et al. concerning the effect of maternal lead on tooth decay in rat pups1. After raising female rat pups exposed to lead in drinking water, the authors measured lead concentrations of various body fluids during pregnancy and ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0198-003a

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Restoration of lymphocyte function in Janus Kinase 3-deficient mice by retroviral-mediated gene transfer (1998)

Bunting, Kevin D. ; Sangster, Mark Y. ; Ihle, James N. ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 58-64

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Janus kinase-3 (JAK3) deficiency has recently been identified as a cause of severe combined immunodeficiency (SCID) in humans. We used a mouse model of Jak3-deficient SCID to test a gene therapy approach for treatment of this disease. Transfer of a Jak3 retroviral vector to repopulat-ing ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0198-058

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HIV-1 Vpr increases viral expression by manipulation of the cell cycle: A mechanism for selection of Vpr in vivo (1998)

Goh, Wei Chun ; Rogel, Mark E. ; Kinsey, C. Matthew ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 65-71

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The human immunodeficiency virus type 1 (HIV-1) encodes a protein, called Vpr, that prevents proliferation of infected cells by arresting them in G2 of the cell cycle. This Vpr-mediated cell-cycle arrest is also conserved among highly divergent simian immunodeficiency viruses, suggesting an ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0198-065

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AMD3100, a small molecule inhibitor of HIV-1 entry via the CXCR4 co-receptor (1998)

Donzella, George A. ; Schols, Dominique ; Lin, Steven W. ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 72-77

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The bicyclam AMD3100 (formula weight 830) blocks HIV-1 entry and membrane fusion via the CXCR4 co-receptor, but not via CCR5. AMD3100 prevents monoclonal antibody 12G5 from binding to CXCR4, but has no effect on binding of monoclonal antibody 2D7 to CCR5. It also inhibits binding of the ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0198-072

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The Scientist as Consultant: Building New Career Opportunuties (1998)

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 101-101

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] by Carl J. Sinderman & Thomas K. Sawyer Plenum Publishing, U.S. $29.95, 340 pp ISBN 0-306–45637-0, 1997 Reviewd By Joseph M. Zockw Director of Screen Development BioDx Inc., Pittsburgh, PA, USA The Scientist as Consultant is a lively guide through the trials and tribulations of ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0198-101a

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Lessons from an age-old war (1998)

Powis, Stephen H.

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 887-888

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] DELVE INTO ANY textbook of immunology and marvel at the intricacies of the immune response. Then pay a visit to your friendly neighborhood transplant clinic and despair at the crude drugs used to suppress this complex system. The truth is that when it comes to designing ways to manipulate the ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0898-887

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Spirochetes come in from the cold (1998)

Barbour, Alan G.

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 890-891

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] RELAPSING FEVER is an ancient human disease characterized by a rise and fall in fever that was recognized by Hippocrates'. The etiologic agents of relapsing fever are spirochete bacteria of the genus Borrelia (see figure), and their vectors are blood-sucking lice and ticks. Lyme disease, caused by ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0898-890

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The unwinding road to cancer (1998)

Mitchell, Alison

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 893-893

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] What causes a cell to switch up a gear from normal to cancerous growth? Known culprits include mutated tumor suppressor genes, cell cycle regulators and DMA repair proteins. Now, according to a report by Oliver Delattre and co-workers in Nature (394, 203–206, 1998), we can add ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0898-893

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GLI gene and rhabdomyosarcoma (1998)

Myklebost, Ola

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 869-869

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] To the editor—Your interesting News & Views item about the etiology of rhabdomyosarcoma1 repeats a common misinterpretation of the cause and effect of gene defects in cancer development. The GLI gene was originally cloned because of its amplification in a gliorna cell line2 and was ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0898-869c

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UK government and the Wellcome Trust shore-up British universities (1998)

Dickson, David

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 871-871

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The world's biggest charity, the Wellcome Trust, is joining forces with the British government in two major efforts to support University-based research in the UK. In a response to recommendations made last year by the Dearing Commission on Higher Education (Nature Med., 4; 539, 1998 & 3; 1185, ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0898-871

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World Bank compounds interest in health (1998)

Dove, Alan

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 873-873

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Spurred on in part by the burgeoning AIDS epidemic, the World Bank (Washington, DC) has become increasingly involved in public health efforts worldwide, leading to a gradual but significant shift in the way such projects are funded and managed. The Bank recently concluded talks with the Indian ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0898-873a

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Increased efforts to educate the British public about bioscience (1998)

Brown, Phyllida

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 875-875

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] British ministers have stepped up their efforts to improve communication between scientists, policy makers and the public on developments in bioscience. Two initiatives were announced by officials in the past few weeks—but the biggest of these has already run into controversy. On July 9th, ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0898-875b

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Meeting signals a turning point in European neuroscience (1998)

Simm, Michael

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 877-877

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] A record number of participants from 22 countries made their way to this year's Forum of European Neuroscience, held in late June in Berlin. The 4000 plus attendance was double that of the last meeting two years ago, an increase attributed largely to better conference publicity, the use of a ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0898-877a

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Self-organization, complexity and chaos: The new biology for medicine (1998)

Coffey, Donald S.

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 882-885

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The immortal molecule within our body is DNA, and as such could represent the reductionist answer to the old question “Where were you before your grandmother was born?” The continuity and capability of a DNA sequence to cycle on through subsequent human generations and to adapt and ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0898-882

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A2M is associated with late-onset Alzheimer disease (1998)

Dennis, Carina

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 888-888

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The APP, PS1 and PS2 genes are known to be associated with 30–40 percent of cases of early onset farnllial Alzheimer disease (AD) but the genetic basic underlying late-onset AD is less well characterized. Now, in a large cohort study, Rudy Tanzi and colleagues (Nature Genet. 19,357–360, ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0898-888

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Late talking toddlers may have special genes (1998)

Gilger, Jeffrey W.

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 892-893

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] OF THE MANY complex human traits, language is among the most interesting in reference to the nature–nurture debate. As a trait unique to humans, spoken language has all of the characteristics needed to fuel questions concerning the relative importance of nature and nurture. Most agree that ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0898-892

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Digitale Medien

How does folic acid prevent neural tube defects? (1998)

Scott, John M.

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 895-896

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] ABOUT 70 PERCENT of neural tube defects (NTDs) during fetal development can be prevented by periconceptional supplementation of the diet with the vitamin, folic acid1. However, the mechanism by which folic acid prevents NTDs is still obscure and its elucidation has been further hampered by the ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0898-895

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State of the art: Atherosclerosis in a limited edition (1998)

Rader, Daniel J. ; FitzGerald, Garret A.

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 899-900

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] ALTHOUGH ATHEROSCLEROTIC CARDIOVASCULAR disease represents the leading cause of death in the United States1, our understanding of its pathogenesis and our ability to prevent its complications remain imperfect. Major contributions have included elucidation of the pathogenic importance of low density ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0898-899

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Digitale Medien

Growing tissues in microgravity (1998)

Unsworth, Brian R. ; Lelkes, Peter I.

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 901-907

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The possibility of creating three-dimensional differentiated tissue-like assemblies by culturing cells in microgravity, either in space or on the ground, offers research opportunities that may lead to the generation of replacement organs for transplantation, and for studying multicellular responses ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0898-901

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Regenerating functional myocardium: Improved performance after skeletal myoblast transplantation (1998)

Taylor, Doris A. ; Atkins, B. Zane ; Hungspreugs, Pinata ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 929-933

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The adult heart lacks reserve cardiocytes and cannot regenerate. Therefore, a large acute myocardial infarction often develops into congestive heart failure. To attempt to prevent this progression, we transplanted skeletal myoblasts into cryoinfarcted myocardium of the same rabbits (autologous ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0898-929

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A minimal glycine-alanine repeat prevents the interaction of ubiquitinated IκBα with the proteasome: a new mechanism for selective inhibition of proteolysis (1998)

Sharipo, Anatoly ; Imreh, Marta ; Leonchiks, Ainars ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 939-944

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The Epstein-Barr virus nuclear antigen 1 contains a glycine-alanine repeat that inhibits in cis MHC class l-restricted presentation. We report here that insertion of a minimal glycine-alanine repeat motif in different positions of IκBα protects this NF-κB inhibitor from ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0898-939

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Restoration of cytomegalovirus-specific CD4 + T-lymphocyte responses after ganciclovir and highly active antiretroviral therapy in individuals infected with HIV-1 (1998)

Komanduri, Krishna V. ; Viswanathan, Mohan N. ; Wieder, Eric D. ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 953-956

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Recent studies of subjects infected with human immunodeficiency virus (HIV-1) have produced conflicting results about the extent of reconstitution possible in the CD4+ lymphocyte repertoire after highly active antiretroviral therapy1–3 (HAART). The effect of HAART on the incidence of ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0898-953

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Par-4 is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer disease (1998)

Guo, Qing ; Fu, Weiming ; Xie, Jun ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 957-962

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Prostate apoptosis response-4 (Par-4) is a protein containing both a leucine zipper and a death domain that was isolated by differential screening for genes upreguiated in prostate cancer cells undergoing apoptosis1,2. Par-4 is expressed in the nervous system3, where its function is unknown. In ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0898-957

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T-cell epitope mapping by flow cytometry (1998)

Kern, Florian ; Surel, Ingolf Pascal ; Brock, Carsten ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 975-978

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The sequences of thousands of proteins are accessible in scientific databases and their number is steadily growing. Protein sequences from a great number of pathogens are thus available for mapping T-cell epitopes that may be used for immunization or immune therapy. One of the major problems ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0898-975

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Vaccine reactions (1998)

Yamazaki, Shudo

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 746-746

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] To the editor—We are extremely concerned about your May issue news article “Are Japanese Researchers Exploiting Thai HIV Patients?”. We believe it contains substantial misinformation and could seriously damage international scientific collaboration, delaying the development of ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0798-746b

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Reply to “Cross-species infection: No news is good news?” (1998)

Henein, Walid ; Chapman, Lousia E.

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 645-645

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Heneine and Chapman reply—Allan reasons that SFV, like SIV, may vary in infectivity and virulence for humans by species origin, and notes that macaques are the most common captive non-human primate (NHP) species, implying that the predominance of baboon-type SFV among the infected workers we ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0698-645a

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Hypocretins or hyporexins? (1998)

Nisoli, Enzo ; Carruba, Michele O. ; Valerio, Alessandra ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 645-645

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] To the editor—Recently Schwartz1 reviewed the importance of two new hypo-thalamic peptides, orexin A, 33 amino acids, and orexin B, 28 amino acids, in energy homeostasis. Molecular genetic studies in rodents have provided convincing evidence supporting relevant roles for several hypothalamic ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0698-645c

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…and in HIV vaccine development (1998)

Birmingham, Karen

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 648-649

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Within weeks of accusations by the dean of Public Health at Allegheny University, Jonathan Mann, that the National Institutes of Health (NIH) is violating human rights through its failure to test current HIV vaccine candidates in Phase III trials (Nature, 392; 527 1998), 75 of America's leading ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0698-648b

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A tale of two cancer drugs (1998)

Cimons, Marlene

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 650-650

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] It seemed too good to be true. And, ultimately, it was. For a few chaotic days, a story prominently displayed on the front page of the normally restrained New York Times prompted a public frenzy among cancer patients, researchers and the media. The piece, written by Gina Kolata, one of the paper's ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0698-650b

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Digitale Medien

The science of art and vice versa (1998)

Birmingham, Karen

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 652-652

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] In an effort to ‘stimulate and capture the public's imagination,’ the world's largest medical research charity, the Wellcome Trust, is spending £80,000 ($125,000) on an initiative that brings artists and scientists together. Now in its second year, the program funds ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0698-652

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Digitale Medien

The next frontier of molecular medicine: Delivery of therapeutics (1998)

Jain, Rakesh K.

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 655-657

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] For any therapy to be successful, it must satisfy two requirements: it must be effective in the in vivo microenvironment and it must reach target cells in vivo in optimal quantities1. Extraordinary advances in molecular biology and biotechnology have helped to identify novel targets and develop a ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0698-655

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Digitale Medien

Keeping up with the Cajal rhythm (1998)

Vanderwinden, Jean-Marie ; Vanderhaeghen, Jean-Jacques

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 765-767

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] THE REPORT ON page 848 of this issue by Thomsen et al.1 settles a long-standing debate over the function of mesenchymal cells in the gut known as interstitial cells of Cajal (ICC). These investigators show that the ICC are the dedicated cells in the gut musculature that generate the rhythmic ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0798-765

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Digitale Medien

Idiotype vaccines: Forgotten but not gone (1998)

Bona, Constantin A.

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 668-669

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] IDIOTYPES ARE ANTIGENIC determinants and phenotypic markers of V-region genes that encode the specificity of antibodies (and T-cell receptors)1. The diversity of antigen receptors on lymphocytes is reflected in the diversity of idiotypes. This means that statistically the antigen dictionary of both ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0698-668

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62

Digitale Medien

à la CART (1998)

Smith, Orla

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 670-670

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The latest addition to the menu of brain peptides that regulate feeding is CART, a hypothalamic neuropeptide that inhibits eating. Peter Kristensen and colleagues Novo Nordisk, Denmark) report that injection of recombinant CART into rat brains blocks feeding behavior, even in starved animals ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0698-670

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Digitale Medien

Predicting and preventing the emergence of antiviral drug resistance in HSV-2 (1998)

Blower, S.M. ; Porco, T.C. ; Darby, G.

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 673-678

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Genital herpes, caused by herpes simplex virus, is the most prevalent sexually transmitted disease worldwide. In many developing countries genital herpes is untreated, and in the United States only 10% of cases are treated. We present a mathematical model that we use as a health policy tool ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0698-673

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Digitale Medien

Role of the Y5 neuropeptide Y receptor in feeding and obesity (1998)

Marsh, Donald J. ; Hollopeter, Gunther ; Kafer, Kathy E. ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 718-721

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Neuropeptide Y (NPY), a 36-amino-acid neuromodulator abundantly expressed in the brain1, has been implicated in the regulation of food intake and body weight2–4. Pharmacological data suggest that NPY's stimulatory effect on appetite is transduced by the G-protein-coupled NPY Y5 receptor5 ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0698-718

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Digitale Medien

Limited CD4 + T-cell renewal in early HIV-1 infection: Effect of highly active antiretroviral therapy (1998)

Fleury, Sylvain ; De Boer, Rob J. ; Rizzardi, G. Paolo ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 794-801

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] It has been postulated that the turnover of CD4+ lymphocytes is increased up to 70-fold in HIV-infected subjects, and that about 109 cells are destroyed and replenished each day1,2. As a result ofthe destruction of large numbers of CD4+ T lymphocytes, the renewal system of CD4+ T cells will ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0798-794

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Digitale Medien

β-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: Implications for Alzheimer's therapy (1998)

Soto, Claudio ; Sigurdsson, Einar M. ; Morelli, Laura ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 822-826

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Inhibition of cerebral amyloid β-protein deposition seems to be an important target for Alzheimer's disease therapy. Amyloidogenesis could be inhibited by short synthetic peptides designed as β-sheet breakers. Here we demonstrate a 5-residue peptide that inhibits amyloid βprotein ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0798-822

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Digitale Medien

Implantation of stimulated homologous macrophages results in partial recovery of paraplegic rats (1998)

Rapalino, O. ; Lazarov-Spiegler, O. ; Agranov, E. ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 814-821

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Postinjury recovery in most tissues requires an effective dialog with macrophages; however, in the mammalian central nervous system, this dialog may be restricted (possibly due to its immune-privileged status), which probably contributes to its regeneration failure. We circumvented this by ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0798-814

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Digitale Medien

Inhibition of presenilin 1 expression is promoted by p53 and p21 WAF-1 and results in apoptosis and tumor suppression (1998)

Roperch, Jean-Pierre ; Alvaro, Véronique ; Prieur, Sylvie ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 835-838

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Previously, we cloned a cDNA fragment, TSIP 2 (tumor suppressor inhibited pathway clone 2), that detects by northern blot analysis of M1-LTR6 cells a 3-kb mRNA downregulated during p53-induced apoptosis1. Cloning the full-length TSIP 2 cDNA showed that it corresponds to the presenilin 1 (PS1) gene, ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0798-835

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Digitale Medien

Cloning and functional analysis of human p51 , which structurally and functionally resembles p53 (1998)

Osada, Motonobu ; Ohba, Mai ; Kawahara, Chikashi ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 839-843

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The p53 tumor suppressor gene, which is induced by DNA damage and/or stress stimuli, causes cells to undergo G1-arrest or apoptotic death; thus it plays an essential role in human carcinogenesis1,2. We have searched for p53-related genes by using degenerate PCR, and have identified two cDNA ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0798-839

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Digitale Medien

Contemporary Endocrinology: G-Proteins, Receptors and Disease (1998)

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 857-857

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Edited by Allen M. Spiegel Humana Press, $135, 336 pp. ISBN: 0-896-03430-5, 1998 REVIEWED BY GRAEME R. MARTIN Head, Department of Molecular Pharmacology, Center for Biological Research, Roche Bioscience R2-101, 3401 Hillview Avenue, Palo Alto, CA 94304 USA G-protein coupled receptors ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0798-857a

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Digitale Medien

In vivo cellular optical coherence tomography imaging (1998)

Boppart, Stephan A. ; Bouma, Brett E. ; Pitris, Costas ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 861-865

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Neoplasias are most responsive to medical intervention at early stages, prior to undergoing metastasis. When these disorders arise from known premalignant states, and if a detection method exists, the high-risk population can be screened to reduce patient morbidity and mortality. Organs where these ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0798-861

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Digitale Medien

Reply to : A role for IL-15 in rheumatoid arthritis? (1998)

Mcinnes, Iain B. ; Leung, Bernard P. ; Feng, Gui-Jie ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 643-643

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] McInnes etal. reply—Shah etal. suggest that measurement of interleukin-15 (IL-15) levels in synovial fluid may be complicated by the presence of rheumatoid factor (RF) (although we note that the level of IL-15 recovered from ‘spiked’ SF in their assay was reduced in the presence ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0698-643b

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Digitale Medien

Human cloning: Safety is the issue (1998)

Galton, D. J. ; Kay, A. ; Cavanna, J. S.

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 644-644

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] To the editor—A unique event occurred in the history of the reproduction of mammals when an adult lamb's nucleus was transferred into an enucleated ovum and led to the birth of the cloned lamb ‘Dolly’1. The public outcry from politicians and laity was immediate and almost ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0698-644a

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Digitale Medien

Cross-species infection: No news is good news? (1998)

Allan, Jonathan S.

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 644-645

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] To the editor—Heneine and coworkers recently described occupational infections of four humans with simian foamy virus (SFV) and reported that none of three infected individuals transmitted SFV to their spouses and there has been no evidence of any diseases that might be related to SFV ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0698-644b

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Tamoxifen, raloxifene findings unlikely to encourage genetic screening for breast cancer (1998)

Dove, Alan

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 647-647

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Reports that two medications can reduce the risk of breast cancer in some patients fueled speculation that genetic screening, particularly for women at high risk for the disease, might become more popular. Genetic testing identifies mutant alleles of the BRCA1 and BRCA2 genes that correlate with a ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0698-647a

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Digitale Medien

Science versus politics … in US needle exchange program (1998)

Cimons, Marlene

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 648-648

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] It was a classic case of science versus politics—and politics won. Armed with an overwhelming body of research establishing the value of needle exchange programs in reducing the spread of HIV without encouraging illegal drug use, US Health and Human Services (HHS) Secretary Donna E. Shalala ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0698-648a

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Bill paves the way for more birth defects research (1998)

Dove, Alan

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 649-649

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] A bill signed into law by President Clinton on April 21st authorizes a substantial increase in federal funding for research into birth defects and opens the door for new initiatives in the future. Representative Solomon Ortiz (D-Texas) has been pushing for passage of the bill since 1992, after a ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0698-649

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UK leads on science and technology bioethics (1998)

Birmingham, Karen

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 651-652

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The US should follow the UK's lead in certain areas of science and technology where ethical decisions are key—such as the development of a national criminal database, reviewing gene therapy protocols, in vitro fertilization regulation and the use of genetic information by insurance ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0698-651b

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Digitale Medien

Nicotine addiction and the lure of reward (1998)

White, Francis J.

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 659-660

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] RAISE TAXES ON cigarettes. Restrict teenagers’ access to tobacco. Eliminate Joe Camel advertising. Use tobacco settlement funds to further health research. Such calls can be heard daily across the United States. The reasons are obvious. Tobacco smoking has been called the chief cause of ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0698-659

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Playing with dopamine release (1998)

Aamodt, Sandra

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 660-660

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] According to Paul Grasby and colleagues (Imperial College School of Medicine, London) in their recent Nature paper, playing a video game stimulates dopamine release in a brain region involved in reward pathways and motor control. As subjects navigated a tank through enemy bunkers, positron emission ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0698-660

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To treat or not to treat? (1998)

Kaplan, Edward H.

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 664-665

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] UNLIKE LOVE, HERPES is forever, but the question remains what to do about it. Episodic outbreaks of genital herpes lesions caused by herpes simplex virus type 2 (HSV-2) can be treated with acyclovir, a drug that also offers benefits if used pro-phylactically. Unfortunately, widespread treatment ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0698-664

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82

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Neuronal grafts for Huntington's disease (1998)

Horellou, Philippe ; Mallet, Jacques

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 669-670

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] DEVELOPING TREATMENTS FOR neurodegenerative diseases requires that treatments be optimized in animal models before they are translated into therapy for patients. The study by Kendall et al.1 on page 727 of this issue addresses the question of whether intracerebral transplants of embryonic striatal ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0698-669

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83

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Vaccination : Only skin deep (1998)

Smith, Orla

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 672-672

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Alternatives to injected vaccines have been vigorously sought not only to allay the fears of the many who wince at a needleprick but to remove the threat of injecting patients using contaminated needles (a particular problem in the Third World). Now Glenn and colleagues from the Walter Reed Army ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0698-672

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84

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Overexpression of E2F‐1 in glioma triggers apoptosis and suppresses tumor growth in vitro and in vivo (1998)

Fueyo, J. ; Gomez-Manzano, C. ; Yung, W.K.A. ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 685-690

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The transfer of apoptosis genes to tumors is one of the most promising strategies for cancer gene therapy. We have shown that massive apoptosis occurs when wild-type p53 expression is induced in glioma cells carrying a p53 gene mutation. However, adenovirus-mediated p53 gene transfer is ineffective ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0698-685

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Physiological degradation converts the soluble syndecan-1 ectodomain from an inhibitor to a potent activator of FGF-2 (1998)

Kato, Masato ; Wang, Huiming ; Kainulainen, Varpu ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 691-697

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The activity of fibroblast growth factor 2 (FGF-2) is stringently controlled. Inactive in undisturbed tissues, it is activated during injury and is critical for tissue repair. We find that this control can be imposed by the soluble syndecan-1 ectodomain, a heparan sulfate proteoglycan shed from ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0698-691

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86

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Idiotypic immunization induces immunity to mutated p53 and tumor rejection (1998)

Ruiz, Pedro J. ; Wolkowicz, Roland ; Waisman, Ari ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 710-712

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The p53 molecule might serve as a common tumor-associated antigen, as the tumor suppressor gene p53 is mutated and the p53 protein is often over-expressed in tumor cells. We report that effective immunity to p53 can be induced through an idiotypic network by immunization of mice with a monoclonal ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0698-710

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87

Digitale Medien

HHV-6 and multiple sclerosis (1998)

Fillet, Anne-Marie ; Lozeron, Pierre ; Augt, Henri ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 537-537

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] To the editor-In the December 1997 issue, Soldan etal.1 propose an association between active HHV-6 infection and multiple sclerosis (MS). Prompted by an immunocytochemical study showing oligodendroglial infection by HHV-6 in MS plaques2, we also investigated a possible link between HHV-6 and MS ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0598-537a

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88

Digitale Medien

Reply 1 to “Xenotransplantation—caution, but no moratorium” (1998)

Bach, Fritz H. ; Forrow, Lachlan ; Daniels, Norman ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 372-373

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Bach et al. reply—Sachs and colleagues make three arguments first two are that (i) the very issues we are raising have been discussed in public meetings for years, and (ii) the national committee we are proposing be formed would ask the same questions that the FDA has already asked. The ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0498-372b

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89

Digitale Medien

Poor reporting of oocyte apoptosis (1998)

Lemmer, Eric R. ; Hall, Pauline De La M. ; Gelderblom, Wentzel C.A. ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 373-373

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] To the editor—We read with interest the report by Perez et al. on chemotherapy-mediated female germ cell destruction, the cover story for the November 1997 issue1. The Sunday Times newspaper (London, UK) reported this research under the headline “Implant offers women lifelong ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0498-373

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90

Digitale Medien

Letter from Shalala feeds organ feud (1998)

Dove, Alan

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 376-376

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] A February 26th letter from US Department of Health and Human Services (HHS) secretary Donna Shalala to members of Congress has launched the latest volley in a dispute between the Federal agency and the nonprofit organization which oversees the nation's organ transplantation network. Shalala ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0498-376a

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91

Digitale Medien

Why vaccines? (1998)

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 474-474

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] This supplement, Nature Medicine's first, is dedicated entirely to the subject of vaccines. Of course it has been known for decades that a single vaccine can save more lives and more money that just about any other medical intervention. So why focus on vaccines now? On examining the ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0598supp-474

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92

Digitale Medien

Panel recommends White House coordinates AIDS vaccine development (1998)

Birmingham, Karen ; Watanabe, Myrna E.

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 477-478

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Twelve months ago, President Clinton declared the US government's commitment to producing an AIDS vaccine within ten years. His statement was based, in large part, on the recommendations of the Presidential Advisory Council on HIV/AIDS (PACHA)–a 33 member panel made up of government, ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0598supp-477b

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93

Digitale Medien

Slow progress in malaria vaccine development (1998)

Dove, Alan

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 479-479

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] In January, a century and five months after the discovery of the parasite that causes malaria, Genzyme Transgenics Corporation announced the development of a system for producing a promising vaccine against the disease. The company has developed a transgenic mouse line that expresses a modified ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0598supp-479

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94

Digitale Medien

Hepatic failure and liver cell damage in acute Wilson's disease involve CD95 (APO-1 /Fas) Mediated apoptosis (1998)

Strand, Susanne ; Hofmann, Walter J. ; Grambihler, Annette ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 588-593

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Wilson's disease can result in fulminant liver failure due to hepatic copper overload. The CD95 system mediates apoptosis and has been demonstrated to be involved in liver disease. In this study CD95 mediated apoptosis was investigated in patients with fulminant hepatic failure in the course of ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0598-588

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95

Digitale Medien

Two strings to the bow of Ebola virus (1998)

Klenk, Hans-Dieter ; Volchkov, Viktor E. ; Feldmann, Heinz

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 388-389

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] MARBURG AND EBOLA virus are filoviruses that cause fulminant hemorrhagic fever in humans and nonhuman primates, killing up to 90 percent of infected individuals. Since the discovery of Marburg virus in 1967 and its better known cousin, Ebola, a few years later, these pathogens have been cause for ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0498-388

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96

Digitale Medien

COX-2 inhibitors for colorectal cancer (1998)

Elder, Douglas J. E. ; Paraskeva, Christos

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 392-393

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] DESPITE PROGRESS IN our understanding of tumor biology, coiorectal cancer continues to be a major cause of death. One promising avenue for preventing this cancer is the use of non-steroidal anti-inflammatory drugs (NSAIDs), such as aspirin and sulindac. However, the use of traditional NSAIDs— ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0498-392

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97

Digitale Medien

Enhanced immunogenicity for CD8+ T cell induction and complete protective efficacy of malaria DNA vaccination by boosting with modified vaccinia virus Ankara (1998)

Schneider, Jörg ; Gilbert, Sarah C. ; Blanchard, Tom J. ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 397-402

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Immunization with irradiated sporozoites can protect against malaria infection and intensive efforts are aimed at reproducing this effect with subunit vaccines. A particular sequence of subunit immunization with pre-erythrocytic antigens of Plasmodium berghei, consisting of single dose priming with ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0498-397

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98

Digitale Medien

Reply to “HHV-6 and multiple sclerosis” (1998)

Jacobson, Steven ; Soldan, Samantha S. ; Berti, Rossana

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 538-538

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Soldan et al. reply—We agree with Fillet et al. that serological studies in MS are difficult to interpret due to defects in immunoregulation which often result in increased antibody titers in MS patients. However we demonstrated that the IgG and IgM antibody responses of MS patients to two ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0598-538

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99

Digitale Medien

Effects of a urinary factor from women in early pregnancy on HIV-1, SIV and associated disease (1998)

Lunardi-Iskandar, Yanto ; Bryant, Joseph L. ; Blattner, William A. ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 428-434

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The effects of clinical grade crude preparations of human chorionic gonadotropin (hCG) on Kaposi's sarcoma, HIV, SIV and hematopoiesis were examined in vitro and in vivo. In contrast to previous studies, we report that the antiviral activity of hCG associated factors is not due to the native hCC ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0498-428

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100

Digitale Medien

Local paracrine effects of estradiol are central to parturition in the rhesus monkey (1998)

Nathanielsz, Peter W. ; Jenkins, Susan L. ; Tame, Jennifer D. ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 4 (1998), S. 456-459

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The central biochemical mechanisms involved in primate parturition are still unclear. Studies in both humans and nonhuman primates such as the baboon and rhesus monkey indicate that many factors play a part in the cascade of interactive positive feedforward loops that progressively promote ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0498-456

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