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  • American Association for the Advancement of Science  (369,592)
  • American Association of Petroleum Geologists (AAPG)
  • Annual Reviews
  • University of Chicago Press
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  • 1
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    University of Chicago Press
    Publication Date: 2024-04-04
    Description: A concise primer that complicates a convenient truth in biology—the divide between germ and somatic cells—with far-reaching ethical and public policy ramifications. Scientists have long held that we have two kinds of cells—germ and soma. Make a change to germ cells—say using genome editing—and that change will appear in the cells of future generations. Somatic cells are “safe” after such tampering; modify your skin cells, and your future children’s skin cells will never know. And, while germ cells can give rise to new generations (including all of the somatic cells in a body), somatic cells can never become germ cells. How did scientists discover this relationship and distinction between somatic and germ cells—the so-called Weismann Barrier—and does it actually exist? Can somatic cells become germ cells in the way germ cells become somatic cells? That is, can germ cells regenerate from somatic cells even though conventional wisdom denies this possibility? Covering research from the late nineteenth century to the 2020s, historian and philosopher of science Kate MacCord explores how scientists came to understand and accept the dubious concept of the Weismann Barrier and what profound implications this convenient assumption has for research and policy, from genome editing to stem cell research, and much more.
    Keywords: germline, germ cell, regeneration, genome editing, cell lineage, Weismann Barrier, August Weismann, germ plasm theory ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::P Mathematics and Science::PD Science: general issues::PDA Philosophy of science ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSF Cellular biology (cytology)
    Language: English
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  • 2
    Publication Date: 2024-01-12
    Description: Mantle-derived noble gases in volcanic gases are powerful tracers of terrestrial volatile evolution, as they contain mixtures of both primordial (from Earth's accretion) and secondary (e.g., radiogenic) isotope signals that characterize the composition of deep Earth. However, volcanic gases emitted through subaerial hydrothermal systems also contain contributions from shallow reservoirs (groundwater, crust, atmosphere). Deconvolving deep and shallow source signals is critical for robust interpretations of mantle-derived signals. Here, we use a novel dynamic mass spectrometry technique to measure argon, krypton, and xenon isotopes in volcanic gas with ultrahigh precision. Data from Iceland, Germany, United States (Yellowstone, Salton Sea), Costa Rica, and Chile show that subsurface isotope fractionation within hydrothermal systems is a globally pervasive and previously unrecognized process causing substantial nonradiogenic Ar-Kr-Xe isotope variations. Quantitatively accounting for this process is vital for accurately interpreting mantle-derived volatile (e.g., noble gas and nitrogen) signals, with profound implications for our understanding of terrestrial volatile evolution.
    Description: Published
    Description: eadg2566
    Description: OSV2: Complessità dei processi vulcanici: approcci multidisciplinari e multiparametrici
    Description: JCR Journal
    Keywords: noble gases ; earth degassing
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 3
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    Annual Reviews
    In:  EPIC3Annual Review of Marine Science, Annual Reviews, 16(1), pp. 513-536, ISSN: 1941-1405
    Publication Date: 2024-01-31
    Description: 〈jats:p〉 For decades, multiple-driver/stressor research has examined interactions among drivers that will undergo large changes in the future: temperature, pH, nutrients, oxygen, pathogens, and more. However, the most commonly used experimental designs—present-versus-future and ANOVA—fail to contribute to general understanding or predictive power. Linking experimental design to process-based mathematical models would help us predict how ecosystems will behave in novel environmental conditions. We review a range of experimental designs and assess the best experimental path toward a predictive ecology. Full factorial response surface, fractional factorial, quadratic response surface, custom, space-filling, and especially optimal and sequential/adaptive designs can help us achieve more valuable scientific goals. Experiments using these designs are challenging to perform with long-lived organisms or at the community and ecosystem levels. But they remain our most promising path toward linking experiments and theory in multiple-driver research and making accurate, useful predictions. 〈/jats:p〉
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , peerRev
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  • 4
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    Annual Reviews
    In:  EPIC3Annual Review of Marine Science, Annual Reviews, 16(1), pp. 417-441, ISSN: 1941-1405
    Publication Date: 2024-03-01
    Description: The genus Phaeocystis is globally distributed, with blooms commonly occurring on continental shelves. This unusual phytoplankter has two major morphologies: solitary cells and cells embedded in a gelatinous matrix. Only colonies form blooms. Their large size (commonly 2 mm but up to 3 cm) and mucilaginous envelope allow the colonies to escape predation, but data are inconsistent as to whether colonies are grazed. Cultured Phaeocystis can also inhibit the growth of co-occurring phytoplankton or the feeding of potential grazers. Colonies and solitary cells use nitrate as a nitrogen source, although solitary cells can also grow on ammonium. Phaeocystis colonies might be a major contributor to carbon flux to depth, but in most cases, colonies are rapidly remineralized in the upper 300 m. The occurrence of large Phaeocystis blooms is often associated with environments with low and highly variable light and high nitrate levels, with Phaeocystis antarctica blooms being linked additionally to high iron availability. Emerging results indicate that different clones of Phaeocystis have substantial genetic plasticity, which may explain its appearance in a variety of environments. Given the evidence of Phaeocystis appearing in new systems, this trend will likely continue in the near future.
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , peerRev
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  • 5
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    University of Chicago Press | University of Chicago Press
    Publication Date: 2024-04-08
    Description: What distinguishes humans from nonhumans? Two common answers—free will and religion—are in some ways fundamentally opposed. Whereas free will enjoys a central place in our ideas of spontaneity, authorship, and deliberation, religious practices seem to involve a suspension of or relief from the exercise of our will. What, then, is agency, and why has it occupied such a central place in theories of the human? Automatic Religion explores an unlikely series of episodes from the end of the nineteenth century, when crucial ideas related to automatism and, in a different realm, the study of religion were both being born. Paul Christopher Johnson draws on years of archival and ethnographic research in Brazil and France to explore the crucial boundaries being drawn at the time between humans, “nearhumans,” and automata. As agency came to take on a more central place in the philosophical, moral, and legal traditions of the West, certain classes of people were excluded as less-than-human. Tracking the circulation of ideas across the Atlantic, Johnson tests those boundaries, revealing how they were constructed on largely gendered and racial foundations. In the process, he reanimates one of the most mysterious and yet foundational questions in trans-Atlantic thought: what is agency?
    Keywords: brazil ; brazilian ; france ; french ; religion ; religious studies ; history ; historical ; humanity ; humans ; nonhumans ; free will ; freedom ; 19th century ; automatism ; ethnography ; archival research ; philosophy ; morality ; ethics ; morals ; ethical ; legalism ; legal ; gender ; race ; anthropology ; determinism ; case study ; culture ; agency ; action ; ability ; understanding ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs::QRM Christianity ; thema EDItEUR::J Society and Social Sciences::JH Sociology and anthropology::JHM Anthropology::JHMC Social and cultural anthropology ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::N History and Archaeology::NH History::NHK History of the Americas ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs::QRM Christianity ; thema EDItEUR::J Society and Social Sciences::JH Sociology and anthropology::JHM Anthropology::JHMC Social and cultural anthropology ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::N History and Archaeology::NH History::NHK History of the Americas
    Language: English
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  • 6
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    University of Chicago Press | University of Chicago Press
    Publication Date: 2024-03-28
    Description: In many ways, divorce is a quintessentially personal decision—the choice to leave a marriage that causes harm or feels unfulfilling to the two people involved. But anyone who has gone through a divorce knows the additional public dimensions of breaking up, from intense shame and societal criticism to friends’ and relatives’ unsolicited advice. In Intimate Disconnections, Allison Alexy tells the fascinating story of the changing norms surrounding divorce in Japan in the early 2000s, when sudden demographic and social changes made it a newly visible and viable option. Not only will one of three Japanese marriages today end in divorce, but divorces are suddenly much more likely to be initiated by women who cite new standards for intimacy as their motivation. As people across Japan now consider divorcing their spouses, or work to avoid separation, they face complicated questions about the risks and possibilities marriage brings: How can couples be intimate without becoming suffocatingly close? How should they build loving relationships when older models are no longer feasible? What do you do, both legally and socially, when you just can’t take it anymore? Relating the intensely personal stories from people experiencing different stages of divorce, Alexy provides a rich ethnography of Japan while also speaking more broadly to contemporary visions of love and marriage during an era in which neoliberal values are prompting wide-ranging transformations in homes across the globe.
    Keywords: divorce ; romance ; marriage ; love ; intimacy ; japan ; trust ; relationships ; commitment ; shame ; social norms ; separation ; women ; gender ; feminism ; asia ; nonfiction ; reference ; freedom ; anxiety ; family ; relationality ; empowerment ; late life ; aging ; anthropology ; sociology ; jukunen rikon ; labor market ; dependence ; self interest ; solitude ; happiness ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general ; thema EDItEUR::J Society and Social Sciences::JH Sociology and anthropology::JHM Anthropology::JHMC Social and cultural anthropology ; thema EDItEUR::J Society and Social Sciences::JH Sociology and anthropology::JHB Sociology::JHBK Sociology: family and relationships
    Language: English
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  • 7
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    University of Chicago Press | University of Chicago Press
    Publication Date: 2024-04-06
    Description: Building the American Republic combines centuries of perspectives and voices into a fluid narrative of the United States. Throughout their respective volumes, Harry L. Watson and Jane Dailey take care to integrate varied scholarly perspectives and work to engage a diverse readership by addressing what we all share: membership in a democratic republic, with joint claims on its self-governing tradition. It will be one of the first peer-reviewed American history textbooks to be offered completely free in digital form. Visit buildingtheamericanrepublic.org for more information. The American nation came apart in a violent civil war less than a century after ratification of the Constitution. When it was reborn five years later, both the republic and its Constitution were transformed. Volume 2 opens as America struggles to regain its footing, reeling from a presidential assassination and facing massive economic growth, rapid demographic change, and combustive politics. The next century and a half saw the United States enter and then dominate the world stage, even as the country struggled to live up to its own principles of liberty, justice, and equality. Volume 2 of Building the American Republic takes the reader from the Gilded Age to the present, as the nation becomes an imperial power, rethinks the Constitution, witnesses the rise of powerful new technologies, and navigates an always-shifting cultural landscape shaped by an increasingly diverse population. Ending with the 2016 election, this volume provides a needed reminder that the future of the American republic depends on a citizenry that understands—and can learn from—its history.
    Keywords: democracy ; immigration ; manifest destiny ; urbanization ; transcontinental railroad ; labor ; slavery ; unions ; working conditions ; farmers alliance ; pullman ; 14th amendment ; jim crow ; reconstruction ; civil war ; patronage ; spanish american ; protest ; social change ; roosevelt ; progressive era ; dollar diplomacy ; revolution 1913 ; suffrage ; empire ; neutrality ; interventionism ; roaring 20s ; sexuality ; feminism ; great depression ; new deal ; south ; race ; ethnicity ; racism ; discrimination ; political movements ; nonfiction ; history ; vietnam ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::N History and Archaeology::NH History::NHK History of the Americas ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPA Political science and theory
    Language: English
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  • 8
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    University of Chicago Press | University of Chicago Press
    Publication Date: 2024-04-04
    Description: Following conflicting desires for an Aztec crown, this book explores the possibilities of repatriation. In The Contested Crown, Khadija von Zinnenburg Carroll meditates on the case of a spectacular feather headdress believed to have belonged to Montezuma, the last emperor of the Aztecs. This crown has long been the center of political and cultural power struggles, and it is one of the most contested museum claims between Europe and the Americas. Taken to Europe during the conquest of Mexico, it was placed at Ambras Castle, the Habsburg residence of the author’s ancestors, and is now in Vienna’s Welt Museum. Mexico has long requested to have it back, but the Welt Museum uses science to insist it is too fragile to travel. Both the biography of a cultural object and a history of collecting and colonizing, this book offers an artist’s perspective on the creative potentials of repatriation. Carroll compares Holocaust and colonial ethical claims, and she considers relationships between indigenous people, international law and the museums that amass global treasures, the significance of copies, and how conservation science shapes collections. Illustrated with diagrams and rare archival material, this book brings together global history, European history, and material culture around this fascinating object and the debates about repatriation.
    Keywords: repatriation ; feather headdress ; mexico ; europe ; colonialism ; history ; aztec ; montezuma ; emperor ; exhibition ; ownership ; possession ; ambras castle ; welt museum ; conquest ; seizure ; dispossession ; holocaust ; looting ; ethics ; reparation ; nonfiction ; indigenous ; international law ; collection ; material culture ; crown ; anthropology ; el penacho ; replica ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::N History and Archaeology::NH History::NHK History of the Americas ; thema EDItEUR::A The Arts::AG The Arts: treatments and subjects::AGA History of art ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GL Library and information sciences / Museology::GLZ Museology and heritage studies ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBS Social groups, communities and identities::JBSL Ethnic studies::JBSL1 Ethnic groups and multicultural studies::JBSL11 Indigenous peoples ; thema EDItEUR::5 Interest qualifiers::5P Relating to specific groups and cultures or social and cultural interests::5PB Relating to peoples: ethnic groups, indigenous peoples, cultures and other groupings of people::5PBA Relating to Indigenous peoples
    Language: English
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  • 9
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    University of Chicago Press | University of Chicago Press
    Publication Date: 2024-04-05
    Description: If you were an independent, adventurous, liberated American woman in the 1920s or 1930s where might you have sought escape from the constraints and compromises of bourgeois living? Paris and the Left Bank quickly come to mind. But would you have ever thought of Russia and the wilds of Siberia? This choice was not as unusual as it seems now. As Julia L. Mickenberg uncovers in American Girls in Red Russia, there is a forgotten counterpoint to the story of the Lost Generation: beginning in the late nineteenth century, Russian revolutionary ideology attracted many women, including suffragists, reformers, educators, journalists, and artists, as well as curious travelers. Some were famous, like Isadora Duncan or Lillian Hellman; some were committed radicals, though more were just intrigued by the “Soviet experiment.” But all came to Russia in search of social arrangements that would be more equitable, just, and satisfying. And most in the end were disillusioned, some by the mundane realities, others by horrifying truths. Mickenberg reveals the complex motives that drew American women to Russia as they sought models for a revolutionary new era in which women would be not merely independent of men, but also equal builders of a new society. Soviet women, after all, earned the right to vote in 1917, and they also had abortion rights, property rights, the right to divorce, maternity benefits, and state-supported childcare. Even women from Soviet national minorities—many recently unveiled—became public figures, as African American and Jewish women noted. Yet as Mickenberg’s collective biography shows, Russia turned out to be as much a grim commune as a utopia of freedom, replete with economic, social, and sexual inequities. American Girls in Red Russia recounts the experiences of women who saved starving children from the Russian famine, worked on rural communes in Siberia, wrote for Moscow or New York newspapers, or performed on Soviet stages. Mickenberg finally tells these forgotten stories, full of hope and grave disappointments.
    Keywords: america ; united states ; russian ; soviet union ; 1920s ; 1930s ; travel ; immigration ; escape ; siberia ; lost generation ; 20th century ; contemporary ; modern ; women ; feminism ; girls ; isadora duncan ; lillian hellman ; radical ; experiment ; equality ; revolutionary ; history ; historical ; men ; patriarchy ; divorce ; rights ; property ; benefits ; maternity ; childcare ; sexual ; economic ; social ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::N History and Archaeology::NH History::NHK History of the Americas ; thema EDItEUR::N History and Archaeology::NH History::NHQ History of other geographical groupings and regions ; thema EDItEUR::D Biography, Literature and Literary studies::DN Biography and non-fiction prose::DNB Biography: general::DNBH Biography: historical, political and military ; thema EDItEUR::D Biography, Literature and Literary studies::DN Biography and non-fiction prose::DNB Biography: general
    Language: English
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  • 10
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    University of Chicago Press | University of Chicago Press
    Publication Date: 2024-04-02
    Description: Weather control. Juxtaposing those two words is enough to raise eyebrows in a world where even the best weather models still fail to nail every forecast, and when the effects of climate change on sea level height, seasonal averages of weather phenomena, and biological behavior are being watched with interest by all, regardless of political or scientific persuasion. But between the late nineteenth century—when the United States first funded an attempt to “shock” rain out of clouds—and the late 1940s, rainmaking (as it had been known) became weather control. And then things got out of control. In Make It Rain, Kristine C. Harper tells the long and somewhat ludicrous history of state-funded attempts to manage, manipulate, and deploy the weather in America. Harper shows that governments from the federal to the local became helplessly captivated by the idea that weather control could promote agriculture, health, industrial output, and economic growth at home, or even be used as a military weapon and diplomatic tool abroad. Clear fog for landing aircraft? There’s a project for that. Gentle rain for strawberries? Let’s do it! Enhanced snowpacks for hydroelectric utilities? Check. The heyday of these weather control programs came during the Cold War, as the atmosphere came to be seen as something to be defended, weaponized, and manipulated. Yet Harper demonstrates that today there are clear implications for our attempts to solve the problems of climate change.
    Keywords: contemporary ; modern ; weather ; control ; models ; forecast ; climate ; sea level ; seasons ; seasonal ; average ; rainfall ; snow ; wind ; behavior ; history ; historical ; 1940s ; funding ; government ; federal ; local ; agriculture ; health ; industry ; economy ; economic ; project ; snowpack ; cold war ; atmosphere ; research ; academic ; scholarly ; diplomacy ; international ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::N History and Archaeology::NH History::NHK History of the Americas ; thema EDItEUR::R Earth Sciences, Geography, Environment, Planning::RB Earth sciences::RBP Meteorology and climatology ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPQ Central / national / federal government::JPQB Central / national / federal government policies
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  • 11
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    University of Chicago Press | University of Chicago Press
    Publication Date: 2024-03-28
    Description: The financial crisis and the recession that followed caught many people off guard, including experts in the financial sector whose jobs involve predicting market fluctuations. Financial analysis offices in most international banks are supposed to forecast the rise or fall of stock prices, the success or failure of investment products, and even the growth or decline of entire national economies. And yet their predictions are heavily disputed. How do they make their forecasts—and do those forecasts have any actual value? Building on recent developments in the social studies of finance, Stories of Capitalism provides the first ethnography of financial analysis. Drawing on two years of fieldwork in a Swiss bank, Stefan Leins argues that financial analysts construct stories of possible economic futures, presenting them as coherent and grounded in expert research and analysis. In so doing, they establish a role for themselves—not necessarily by laying bare empirically verifiable trends but rather by presenting the market as something that makes sense and is worth investing in. Stories of Capitalism is a nuanced look at how banks continue to boost investment—even in unstable markets—and a rare insider’s look into the often opaque financial practices that shape the global economy.
    Keywords: capitalist ; money ; monetary ; wealth ; finances ; finance ; analysis ; crisis ; recession ; history ; historical ; academic ; scholarly ; research ; market ; job ; career ; sector ; international ; banks ; banking ; stocks ; prices ; success ; failure ; forecast ; prediction ; trends ; data ; global ; value ; information ; investment ; economy ; narrative ; story ; construction ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general ; thema EDItEUR::J Society and Social Sciences::JH Sociology and anthropology::JHM Anthropology::JHMC Social and cultural anthropology ; thema EDItEUR::K Economics, Finance, Business and Management::KF Finance and accounting::KFF Finance and the finance industry
    Language: English
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  • 12
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    University of Chicago Press | University of Chicago Press
    Publication Date: 2024-03-28
    Description: How researchers understood the atomic bomb’s effects on the human psyche before the recognition of Post-Traumatic Stress Disorder. In 1945, researchers on a mission to Hiroshima with the United States Strategic Bombing Survey canvassed survivors of the nuclear attack. This marked the beginning of global efforts—by psychiatrists, psychologists, and other social scientists—to tackle the complex ways in which human minds were affected by the advent of the nuclear age. A trans-Pacific research network emerged that produced massive amounts of data about the dropping of the bomb and subsequent nuclear tests in and around the Pacific rim. Ran Zwigenberg traces these efforts and the ways they were interpreted differently across communities of researchers and victims. He explores how the bomb’s psychological impact on survivors was understood before we had the concept of post-traumatic stress disorder. In fact, psychological and psychiatric research on Hiroshima and Nagasaki rarely referred to trauma or similar categories. Instead, institutional and political constraints—most notably the psychological sciences’ entanglement with Cold War science—led researchers to concentrate on short-term damage and somatic reactions or even, in some cases, on denial of victims’ suffering. As a result, very few doctors tried to ameliorate suffering. But, Zwigenberg argues, it was not only that doctors “failed” to issue the right diagnosis; the victims’ experiences also did not necessarily conform to our contemporary expectations. As he shows, the category of trauma should not be used uncritically in a non-Western context. Consequently, this book sets out, first, to understand the historical, cultural, and scientific constraints in which researchers and victims were acting and, second, to explore how suffering was understood in different cultural contexts before PTSD was a category of analysis
    Keywords: Hiroshima; nuclear trauma; Cold War; psychology; psychiatry; Post-Traumatic Stress Disorder ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general ; thema EDItEUR::J Society and Social Sciences::JM Psychology::JMP Abnormal psychology ; thema EDItEUR::J Society and Social Sciences::JW Warfare and defence::JWM Weapons and equipment::JWMN Nuclear weapons
    Language: English
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  • 13
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    University of Chicago Press
    Publication Date: 2024-05-12
    Description: In Jane Addams’s Evolutionary Theorizing, Marilyn Fischer advances the bold and original claim that Addams’s reasoning in her first book, Democracy and Social Ethics, is thoroughly evolutionary. While Democracy and Social Ethics, a foundational text of classical American pragmatism, is praised for advancing a sensitive and sophisticated method of ethical deliberation, Fischer is the first to explore its intellectual roots. Examining essays Addams wrote in the 1890s and showing how they were revised for Democracy and Social Ethics, Fischer draws from philosophy, history, literature, rhetoric, and more to uncover the array of social evolutionary thought Addams engaged with in her texts—from British socialist writings on the evolution of democracy to British and German anthropological accounts of the evolution of morality. By excavating Addams’s evolutionary reasoning and rhetorical strategies, Fischer reveals the depth, subtlety, and richness of Addams’s thought.
    Keywords: jane addams, socialism, socialist, united states of america, american history, usa, settlement activist, activism, reformer, social worker, sociology, public administrator, suffrage, womens rights, world peace, hull house, civil liberties union, philosophy, ethics, morality, pragmatism, deliberation, democracy, 19th century, evolution, immigration, science, morals, ethical considerations
    Language: English
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  • 14
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    University of Chicago Press | University of Chicago Press
    Publication Date: 2024-04-07
    Description: Drive the streets of Nairobi, and you are sure to see many matatus—colorful minibuses that transport huge numbers of people around the city. Once ramshackle affairs held together with duct tape and wire, matatus today are name-brand vehicles maxed out with aftermarket detailing. They can be stately black or extravagantly colored, sporting names, slogans, or entire tableaus, with airbrushed portraits of everyone from Kanye West to Barack Obama. In this richly interdisciplinary book, Kenda Mutongi explores the history of the matatu from the 1960s to the present. As Mutongi shows, matatus offer a window onto the socioeconomic and political conditions of late-twentieth-century Africa. In their diversity of idiosyncratic designs, they reflect multiple and divergent aspects of Kenyan life—including, for example, rapid urbanization, organized crime, entrepreneurship, social insecurity, the transition to democracy, and popular culture—at once embodying Kenya’s staggering social problems as well as the bright promises of its future. Offering a shining model of interdisciplinary analysis, Mutongi mixes historical, ethnographic, literary, linguistic, and economic approaches to tell the story of the matatu and explore the entrepreneurial aesthetics of the postcolonial world.
    Keywords: east african history ; mass transit ; kenya ; africa ; public transportation ; ethnic studies ; nairobi ; matatu ; matatus ; colorful minibus ; ramshackle ; vehicles ; aftermarket detailing ; taxis ; kanye west ; barack obama ; interdisciplinary research ; 1960s ; 20th century ; socioeconomic ; political conditions ; diversity ; idiosyncratic designs ; kenyan life ; rapid urbanization ; organized crime ; entrepreneurship ; social insecurity ; transition to democracy ; society ; popular culture ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::N History and Archaeology::NH History::NHH African history ; thema EDItEUR::J Society and Social Sciences::JH Sociology and anthropology::JHM Anthropology ; thema EDItEUR::W Lifestyle, Hobbies and Leisure::WG Transport: general interest::WGC Road and motor vehicles: general interest::WGCF Buses, trams and commercial vehicles: general interest ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBS Social groups, communities and identities::JBSD Urban communities
    Language: English
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  • 15
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    University of Chicago Press | University of Chicago Press
    Publication Date: 2024-04-02
    Description: Building the American Republic combines centuries of perspectives and voices into a fluid narrative of the United States. Throughout their respective volumes, Harry L. Watson and Jane Dailey take care to integrate varied scholarly perspectives and work to engage a diverse readership by addressing what we all share: membership in a democratic republic, with joint claims on its self-governing tradition. It will be one of the first peer-reviewed American history textbooks to be offered completely free in digital form. Visit buildingtheamericanrepublic.org for more information. Volume 1 starts at sea and ends on the battlefield. Beginning with the earliest Americans and the arrival of strangers on the eastern shore, it then moves through colonial society to the fight for independence and the construction of a federalist republic. From there, it explains the renegotiations and refinements that took place as a new nation found its footing, and it traces the actions that eventually rippled into the Civil War. This volume goes beyond famous names and battles to incorporate politics, economics, science, arts, and culture. And it shows that issues that resonate today—immigration, race, labor, gender roles, and the power of technology—have been part of the American fabric since the very beginning.
    Keywords: history ; historical ; southern culture ; united states of america ; american ; usa ; cultural ; democratic republic ; government ; governing ; digital textbook ; americans ; colonies ; colonization ; independence ; revolution ; federalist ; civil war ; slavery ; politics ; economics ; science ; arts ; society ; immigration ; race ; racism ; labor ; gender roles ; technology ; agriculture ; native peoples ; slave trade ; columbus ; conquest ; puritans ; religion ; jamestown ; salem ; kkk ; reconstruction ; george washington ; abraham lincoln ; manifest destiny ; democracy ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::N History and Archaeology::NH History::NHK History of the Americas ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPA Political science and theory
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  • 16
    Publication Date: 2024-02-07
    Description: Organisms experience environments that vary across both space and time. Such environmental heterogeneity shapes standing genetic variation and may influence species’ capacity to adapt to rapid environmental change. However, we know little about the kindof genetic variation that is involved in local adaptation to environmental variability. To address this gap, we sequenced the whole genomes of 140 purple sea urchins (Strongylocentrotus purpuratus) from seven populations that vary in their degree of pH variability. Despite no evidence of global population structure, we found a suite of single-nucleotide polymorphisms (SNPs) tightly correlated with local pH variability (outlier SNPs), which were overrepresented in regions putatively involved in gene regulation (long noncoding RNA and enhancers), supporting the idea that variation in regulatory regions is important for local adaptation to variability. In addition, outliers in genes were found to be (i) enriched for biomineralization and ion homeostasis functions related to low pH response, (ii) less central to the protein-protein interaction network, and (iii) underrepresented among genes highly expressed during early development. Taken together, these results suggest that loci that underlie local adaptation to pH variability in purple sea urchins fall in regions with potentially low pleiotropic effects (based on analyses involving regulatory regions, network centrality, and expression time) involved in low pH response (based on functional enrichment).
    Type: Article , PeerReviewed
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  • 17
    Publication Date: 2023-02-28
    Description: © The Author(s), 2023. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Timmermans, M.-L., & Toole, J. The Arctic Ocean’s Beaufort Gyre. Annual Review of Marine Science, 15(1), (2023): 223-248, https://doi.org/10.1146/annurev-marine-032122-012034.
    Description: The Arctic Ocean's Beaufort Gyre is a dominant feature of the Arctic system, a prominent indicator of climate change, and possibly a control factor for high-latitude climate. The state of knowledge of the wind-driven Beaufort Gyre is reviewed here, including its forcing, relationship to sea-ice cover, source waters, circulation, and energetics. Recent decades have seen pronounced change in all elements of the Beaufort Gyre system. Sea-ice losses have accompanied an intensification of the gyre circulation and increasing heat and freshwater content. Present understanding of these changes is evaluated, and time series of heat and freshwater content are updated to include the most recent observations.
    Description: Support was provided by the National Science Foundation Office of Polar Programs and the Office of Naval Research.
    Keywords: Arctic Ocean ; Beaufort Gyre ; Circulation ; Sea ice ; Freshwater ; Ocean heat content
    Repository Name: Woods Hole Open Access Server
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  • 18
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    Unknown
    Annual Reviews
    In:  EPIC3Annual Review of Marine Science, Annual Reviews, 15(1), pp. 509-538, ISSN: 1941-1405
    Publication Date: 2024-05-10
    Description: The regular movements of waves and tides are obvious representations of the oceans’ rhythmicity. But the rhythms of marine life span across ecological niches and timescales, including short (in the range of hours) and long (in the range of days and months) periods. These rhythms regulate the physiology and behavior of individuals, as well as their interactions with each other and with the environment. This review highlights examples of rhythmicity in marine animals and algae that represent important groups of marine life across different habitats. The examples cover ecologically highly relevant species and a growing number of laboratory model systems that are used to disentangle key mechanistic principles. The review introduces fundamental concepts of chronobiology, such as the distinction between rhythmic and endogenous oscillator–driven processes. It also addresses the relevance of studying diverse rhythms and oscillators, as well as their interconnection, for making better predictions of how species will respond to environmental perturbations, including climate change. As the review aims to address scientists from the diverse fields of marine biology, ecology, and molecular chronobiology, all of which have their own scientific terms, we provide definitions of key terms throughout the article.
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , isiRev
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  • 19
    Publication Date: 2024-02-07
    Description: Organic matter (OM) plays a significant role in the formation of oxygen minimum zones (OMZs) and associated biogeochemical cycling. OM supply processes to the OMZ include physical transport, particle formation, and sinking as well as active transport by migrating zooplankton and nekton. In addition to the availability of oxygen and other electron acceptors, the remineralization rate of OM is controlled by its biochemical quality. Enhanced microbial respiration of OM can induce anoxic microzones in an otherwise oxygenated water column. Reduced OM degradation under low-oxygen conditions, on the other hand, may increase the CO2 storage time in the ocean. Understanding the interdependencies between OM and oxygen cycling is of high relevance for an ocean facing deoxygenation as a consequence of global warming. In this review, we describe OM fluxes into and cycling within two large OMZs associated with eastern boundary upwelling systems that differ greatly in the extent of oxygen loss: the highly oxygen-depleted OMZ in the tropical South Pacific and the moderately hypoxic OMZ in the tropical North Atlantic. We summarize new findings from a large German collaborative research project, Collaborative Research Center 754 (SFB 754), and identify knowledge gaps and future research priorities.
    Type: Article , PeerReviewed , info:eu-repo/semantics/article
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  • 20
    Publication Date: 2024-02-07
    Description: The colonization of land by plants generated opportunities for the rise of new heterotrophic life forms, including humankind. A unique event underpinned this massive change to earth ecosystems-the advent of eukaryotic green algae. Today, an abundant marine green algal group, the prasinophytes, alongside prasinodermophytes and nonmarine chlorophyte algae, is facilitating insights into plant developments. Genome-level data allow identification of conserved proteins and protein families with extensive modifications, losses, or gains and expansion patterns that connect to niche specialization and diversification. Here, we contextualize attributes according to Viridiplantae evolutionary relationships, starting with orthologous protein families, and then focusing on key elements with marked differentiation, resulting in patchy distributions across green algae and plants. We place attention on peptidoglycan biosynthesis, important for plastid division and walls; phytochrome photosensors that are master regulators in plants; and carbohydrate-active enzymes, essential to all manner of carbohydratebiotransformations. Together with advances in algal model systems, these areas are ripe for discovering molecular roles and innovations within and across plant and algal lineages
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  • 21
    Publication Date: 2024-02-07
    Description: Bacterial symbionts are functionally integral to animal reproduction and development, some of which have evolved additional mechanisms to override these host programs. One habitat that is increasingly recognized to contain phylogenetically related lineages of reproductive manipulators is the ocean. The reproduction of marine invertebrates often occurs by free spawning instead of by the physical contact of copulation in terrestrial systems. We developed an integrated model to understand whether and when microbes that manipulate host reproduction by cytoplasmic incompatibility, feminization, and male killing spread within populations of free-spawning marine invertebrates. Our model supports three primary findings. First, sex ratio distortion leads to suboptimal fertilization and zygote production in planktotrophs (feeding larvae) but enhance these processes in lecithotrophs (nonfeeding larvae). Second, feminization and a combination of male killing plus enhanced growth are effective at spreading reproductive manipulators while also inducing a female-biased sex ratio. Third, the majority of free-spawning marine invertebrates could be infected across a range of life history combinations, with infections harming species with smaller eggs and longer pelagic durations while benefiting species with larger eggs and shorter pelagic durations. Together, this supports the general premise that microbes may manipulate the reproduction of free-spawning marine invertebrates (e.g., by inducing changes in developmental life history) and that these types of manipulations overlap considerably with terrestrial systems.
    Type: Article , PeerReviewed , info:eu-repo/semantics/article
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  • 22
    Publication Date: 2023-01-10
    Description: Author Posting. © University of Chicago, 2022. This article is posted here by permission of University of Chicago for personal use, not for redistribution. The definitive version was published in Biological Bulletin 242(1), (2022): 62-73, https://doi.org/10.1086/716711.
    Description: We tested the impact of temperature and symbiont state on calcification in corals, using the facultatively symbiotic coral Astrangia poculata as a model system. Symbiotic and aposymbiotic colonies of A. poculata were reared in 15, 20, and 27 °C conditions. We used scanning electron microscopy to quantify how these physiological and environmental conditions impact skeletal structure. Buoyant weight data over time revealed that temperature significantly affects calcification rates. Scanning electron microscopy of A. poculata skeletons showed that aposymbiotic colonies appear to have a lower density of calcium carbonate in actively growing septal spines. We describe a novel approach to analyze the roughness and texture of scanning electron microscopy images. Quantitative analysis of the roughness of septal spines revealed that aposymbiotic colonies have a rougher surface than symbiotic colonies in tropical conditions (27 °C). This trend reversed at 15 °C, a temperature at which the symbionts of A. poculata may exhibit parasitic properties. Analysis of surface texture patterns showed that temperature impacts the spatial variance of crystals on the spine surface. Few published studies have examined the skeleton of A. poculata by using scanning electron microscopy. Our approach provides a way to study detailed changes in skeletal microstructure in response to environmental parameters and can serve as a proxy for more expensive and time-consuming analyses. Utilizing a facultatively symbiotic coral that is native to both temperate and tropical regions provides new insights into the impact of both symbiosis and temperature on calcification in corals.
    Description: This work was supported by the Marine Biological Laboratory and the University of Chicago Metcalf program and by a National Institutes of Health Research Project Grant (grant R01EB26300 to PJLR).
    Description: 2023-01-10
    Repository Name: Woods Hole Open Access Server
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  • 23
    Publication Date: 2022-09-13
    Description: © The Author(s), 2022. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Liu, C.-Z., Dick, H. J. B., Mitchell, R. N., Wei, W., Zhang, Z.-Y., Hofmann, A. W., Yang, J.-F., & Li, Y. Archean cratonic mantle recycled at a mid-ocean ridge. Science Advances, 8(22), (2022): eabn6749, https://doi.org/10.1126/sciadv.abn6749.
    Description: Basalts and mantle peridotites of mid-ocean ridges are thought to sample Earth’s upper mantle. Osmium isotopes of abyssal peridotites uniquely preserve melt extraction events throughout Earth history, but existing records only indicate ages up to ~2 billion years (Ga) ago. Thus, the memory of the suspected large volumes of mantle lithosphere that existed in Archean time (〉2.5 Ga) has apparently been lost somehow. We report abyssal peridotites with melt-depletion ages up to 2.8 Ga, documented by extremely unradiogenic 187Os/188Os ratios (to as low as 0.1095) and refractory major elements that compositionally resemble the deep keels of Archean cratons. These oceanic rocks were thus derived from the once-extensive Archean continental keels that have been dislodged and recycled back into the mantle, the feasibility of which we confirm with numerical modeling. This unexpected connection between young oceanic and ancient continental lithosphere indicates an underappreciated degree of compositional recycling over time.
    Description: This study was financially supported by the National Science Fund for Distinguished Young Scholars 42025201 (to C.-Z.L.), the National Key Research and Development Project of China 2020YFA0714801 (to C.-Z.L.), the Strategic Priority Research Program of the Chinese Academy of Sciences XDA13010106 (to C.-Z.L.), the Strategic Priority Research Program of the Chinese Academy of Sciences XDB42020301 (to C.-Z.L.), and NSF grants 2114652 and 1657983 (to H.J.B.D.).
    Repository Name: Woods Hole Open Access Server
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  • 24
    Publication Date: 2022-10-27
    Description: This paper is not subject to U.S. copyright. The definitive version was published in Sherwood, C. R., van Dongeren, A., Doyle, J., Hegermiller, C. A., Hsu, T.-J., Kalra, T. S., Olabarrieta, M., Penko, A. M., Rafati, Y., Roelvink, D., van der Lugt, M., Veeramony, J., & Warner, J. C. Modeling the morphodynamics of coastal responses to extreme events: what shape are we in? Annual Review of Marine Science, 14, (2022): 457–492, https://doi.org/10.1146/annurev-marine-032221-090215.
    Description: This review focuses on recent advances in process-based numerical models of the impact of extreme storms on sandy coasts. Driven by larger-scale models of meteorology and hydrodynamics, these models simulate morphodynamics across the Sallenger storm-impact scale, including swash,collision, overwash, and inundation. Models are becoming both wider (as more processes are added) and deeper (as detailed physics replaces earlier parameterizations). Algorithms for wave-induced flows and sediment transport under shoaling waves are among the recent developments. Community and open-source models have become the norm. Observations of initial conditions (topography, land cover, and sediment characteristics) have become more detailed, and improvements in tropical cyclone and wave models provide forcing (winds, waves, surge, and upland flow) that is better resolved and more accurate, yielding commensurate improvements in model skill. We foresee that future storm-impact models will increasingly resolve individual waves, apply data assimilation, and be used in ensemble modeling modes to predict uncertainties.
    Description: All authors except D.R. were partially supported by the IFMSIP project, funded by US Office of Naval Research grant PE 0601153N under contracts N00014-17-1-2459 (Deltares), N00014-18-1-2785 (University of Delaware), N0001419WX00733 (US Naval Research Laboratory, Monterey), N0001418WX01447 (US Naval Research Laboratory, Stennis Space Center), and N0001418IP00016 (US Geological Survey). C.R.S., C.A.H., T.S.K., and J.C.W. were supported by the US Geological Survey Coastal/Marine Hazards and Resources Program. A.v.D. and M.v.d.L. were supported by the Deltares Strategic Research project Quantifying Flood Hazards and Impacts. M.O. acknowledges support from National Science Foundation project OCE-1554892.
    Keywords: Coastal morphodynamics ; Extreme storms ; Coastal modeling ; Sandy coasts ; Waves ; Sediment transport
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  • 25
    Publication Date: 2022-05-27
    Description: © The Author(s), 2021. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Zhang, Y., Gazel, E., Gaetani, G. A., & Klein, F. Serpentinite-derived slab fluids control the oxidation state of the subarc mantle. Science Advances, 7(48), (2021): eabj2515, https://doi.org/10.1126/sciadv.abj2515.
    Description: Recent geochemical evidence confirms the oxidized nature of arc magmas, but the underlying processes that regulate the redox state of the subarc mantle remain yet to be determined. We established a link between deep subduction-related fluids derived from dehydration of serpentinite ± altered oceanic crust (AOC) using B isotopes and B/Nb as fluid proxies, and the oxidized nature of arc magmas as indicated by Cu enrichment during magma evolution and V/Yb. Our results suggest that arc magmas derived from source regions influenced by a greater serpentinite (±AOC) fluid component record higher oxygen fugacity. The incorporation of this component into the subarc mantle is controlled by the subduction system’s thermodynamic conditions and geometry. Our results suggest that the redox state of the subarc mantle is not homogeneous globally: Primitive arc magmas associated with flat, warm subduction are less oxidized overall than those generated in steep, cold subduction zones.
    Description: Y.Z. acknowledges funding from the National Science Foundation of China (91958213), the Chinese Academy of Sciences (XDB42020402), and the Shandong Provincial Natural Science Foundation, China (ZR2020QD068). This study was supported in part by the U.S. National Science Foundation NSF EAR 1826673 to E.G. and G.A.G. and OCE 1756349 to E.G.
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  • 26
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    Unknown
    American Association for the Advancement of Science
    Publication Date: 2022-06-09
    Description: © The Author(s), 2022. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Freeman, D. H., & Ward, C. P. Sunlight-driven dissolution is a major fate of oil at sea. Science Advances, 8(7), (2022): eabl7605, https://doi.org/10.1126/sciadv.abl7605.
    Description: Oxygenation reactions initiated by sunlight can transform insoluble components of crude oil at sea into water-soluble products, a process called photo-dissolution. First reported a half century ago, photo-dissolution has never been included in spill models because key parameters required for rate modeling were unknown, including the wavelength and photon dose dependence. Here, we experimentally quantified photo-dissolution as a function of wavelength and photon dose, making possible a sensitivity analysis of environmental variables in hypothetical spill scenarios and a mass balance assessment for the 2010 Deepwater Horizon (DwH) spill. The sensitivity analysis revealed that rates were most sensitive to oil slick thickness, season/latitude, and wavelength and less sensitive to photon dose. We estimate that 3 to 17% (best estimate 8%) of DwH surface oil was subject to photo-dissolution, comparable in magnitude to other widely recognized fate processes. Our findings invite a critical reevaluation of surface oil budgets for both DwH and future spills at sea.
    Description: This work was supported by the Fisheries and Oceans Canada Multi-Partner Research Initiative award to C.P.W. (project #1.06), the NSF Graduate Research Fellowship awarded to D.H.F. (award #174530), and NSF-OCE grant #1841092 to C.P.W.
    Repository Name: Woods Hole Open Access Server
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  • 27
    Publication Date: 2022-07-25
    Description: © The Author(s), 2022. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Peng, Q., Xie, S.-P., Wang, D., Huang, R. X., Chen, G., Shu, Y., Shi, J.-R., & Liu, W. Surface warming-induced global acceleration of upper ocean currents. Science Advances, 8(16), (2022): eabj8394, https://doi.org/10.1126/sciadv.abj8394.
    Description: How the ocean circulation changes in a warming climate is an important but poorly understood problem. Using a global ocean model, we decompose the problem into distinct responses to changes in sea surface temperature, salinity, and wind. Our results show that the surface warming effect, a robust feature of anthropogenic climate change, dominates and accelerates the upper ocean currents in 77% of the global ocean. Specifically, the increased vertical stratification intensifies the upper subtropical gyres and equatorial currents by shoaling these systems, while the differential warming between the Southern Ocean upwelling zone and the region to the north accelerates surface zonal currents in the Southern Ocean. In comparison, the wind stress and surface salinity changes affect regional current systems. Our study points a way forward for investigating ocean circulation change and evaluating the uncertainty.
    Description: Q.P. is supported by the National Natural Science Foundation of China (42005035), the Science and Technology Planning Project of Guangzhou (202102020935), and the Independent Research Project Program of State Key Laboratory of Tropical Oceanography (LTOZZ2102). D.W. is supported by the National Natural Science Foundation of China (92158204), and the Innovation Group Project of Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai) (311020004). S.-P.X. is supported by the National Science Foundation (AGS-1934392). Y.S. is supported by the National Key Research and Development Program of China (2016YFC1401702). G.C. is supported by National Natural Science Foundation of China (41822602). The numerical simulation is supported by the High-Performance Computing Division and HPC managers of W. Zhou and D. Sui in the South China Sea Institute of Oceanology.
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  • 28
    Publication Date: 2021-08-20
    Description: Species tree estimation is a basic part of many biological research projects, ranging from answering basic evolutionary questions (e.g., how did a group of species adapt to their environments?) to addressing questions in functional biology. Yet, species tree estimation is very challenging, due to processes such as incomplete lineage sorting, gene duplication and loss, horizontal gene transfer, and hybridization, which can make gene trees differ from each other and from the overall evolutionary history of the species. Over the last 10–20 years, there has been tremendous growth in methods and mathematical theory for estimating species trees and phylogenetic networks, and some of these methods are now in wide use. In this survey, we provide an overview of the current state of the art, identify the limitations of existing methods and theory, and propose additional research problems and directions. Expected final online publication date for the Annual Review of Ecology, Evolution, and Systematics, Volume 52 is November 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
    Print ISSN: 1543-592X
    Electronic ISSN: 1545-2069
    Topics: Biology
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  • 29
    Publication Date: 2021-08-20
    Description: In this article, we review the nascent literature on the transmission of negative policy rates. We discuss the theory of how the transmission depends on bank balance sheets, and how this changes once policy rates become negative. We review the growing evidence that negative policy rates are special because the pass-through to banks’ retail deposit rates is hindered by a zero lower bound. We summarize existing research on the impact of negative rates on banks’ lending and securities portfolios as well as their consequences for the real economy. Finally, we discuss the role of different initial conditions when the policy rate becomes negative, and potential interactions between negative policy rates and other unconventional monetary policies. Expected final online publication date for the Annual Review of Financial Economics, Volume 13 is November 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
    Print ISSN: 1941-1367
    Electronic ISSN: 1941-1375
    Topics: Economics
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  • 30
    Publication Date: 2021-08-20
    Description: Bacterial stress-signaling alarmones are important components of a protective network against diverse stresses such as nutrient starvation and antibiotic assault. pppGpp and ppGpp, collectively (p)ppGpp, have well-documented regulatory roles in gene expression and protein translation. Recent work has highlighted another key function of (p)ppGpp: inducing rapid and coordinated changes in cellular metabolism by regulating enzymatic activities, especially those involved in purine nucleotide synthesis. Failure of metabolic regulation by (p)ppGpp results in the loss of coordination between metabolic and macromolecular processes, leading to cellular toxicity. In this review, we document how (p)ppGpp and newly characterized nucleotides pGpp and (p)ppApp directly regulate these enzymatic targets for metabolic remodeling. We examine targets’ common determinants for alarmone interaction as well as their evolutionary diversification. We highlight classical and emerging themes in nucleotide signaling, including oligomerization and allostery along with metabolic interconversion and crosstalk, illustrating how they allow optimized bacterial adaptation to their environmental niches. Expected final online publication date for the Annual Review of Genetics, Volume 55 is November 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
    Print ISSN: 0066-4197
    Electronic ISSN: 1545-2948
    Topics: Biology
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  • 31
    Publication Date: 2021-08-20
    Description: The large-scale dynamics of ocean oxygenation have changed dramatically throughout Earth's history, in step with major changes in the abundance of O2 in the atmosphere and changes to marine nutrient availability. A comprehensive mechanistic understanding of this history requires insights from oceanography, marine geology, geochemistry, geomicrobiology, evolutionary ecology, and Earth system modeling. Here, we attempt to synthesize the major features of evolving ocean oxygenation on Earth through more than 3 billion years of planetary history. We review the fundamental first-order controls on ocean oxygen distribution and summarize the current understanding of the history of ocean oxygenation on Earth from empirical and theoretical perspectives—integrating geochemical reconstructions of oceanic and atmospheric chemistry, genomic constraints on evolving microbial metabolism, and mechanistic biogeochemical models. These changes are used to illustrate primary regimes of large-scale ocean oxygenation and to highlight feedbacks that can act to stabilize and destabilize the ocean–atmosphere system in anoxic, low-oxygen, and high-oxygen states. Expected final online publication date for the Annual Review of Marine Science, Volume 14 is January 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
    Print ISSN: 1941-1405
    Electronic ISSN: 1941-0611
    Topics: Biology , Geosciences
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  • 32
    Publication Date: 2021-08-20
    Description: The SUP05 clade of gammaproteobacteria (Thioglobaceae) comprises both primary producers and primary consumers of organic carbon in the oceans. Host-associated autotrophs are a principal source of carbon and other nutrients for deep-sea eukaryotes at hydrothermal vents, and their free-living relatives are a primary source of organic matter in seawater at vents and in marine oxygen minimum zones. Similar to other abundant marine heterotrophs, such as SAR11 and Roseobacter, heterotrophic Thioglobaceae use the dilute pool of osmolytes produced by phytoplankton for growth, including methylated amines and sulfonates. Heterotrophic members are common throughout the ocean, and autotrophic members are abundant at hydrothermal vents and in anoxic waters; combined, they can account for more than 50% of the total bacterial community. Studies of both cultured and uncultured representatives from this diverse family are providing novel insights into the shifting biogeochemical roles of autotrophic and heterotrophic bacteria that cross oxic–anoxic boundary layers in the ocean. Expected final online publication date for the Annual Review of Marine Science, Volume 14 is January 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
    Print ISSN: 1941-1405
    Electronic ISSN: 1941-0611
    Topics: Biology , Geosciences
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  • 33
    Publication Date: 2021-08-20
    Description: Beyond the better-studied carbohydrates and the macronutrients nitrogen and phosphorus, a remaining 20 or so elements are essential for life and have distinct geographical distributions, making them of keen interest to ecologists. Here, I provide a framework for understanding how shortfalls in micronutrients like iodine, copper, and zinc can regulate individual fitness, abundance, and ecosystem function. With a special focus on sodium, I show how simple experiments manipulating biogeochemistry can reveal why many of the variables that ecologists study vary so dramatically from place to place. I conclude with a discussion of how the Anthropocene's changing temperature, precipitation, and atmospheric CO2 levels are contributing to nutrient dilution (decreases in the nutrient quality at the base of food webs). Expected final online publication date for the Annual Review of Ecology, Evolution, and Systematics, Volume 52 is November 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
    Print ISSN: 1543-592X
    Electronic ISSN: 1545-2069
    Topics: Biology
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  • 34
    Publication Date: 2021-08-20
    Description: A key Earth system science question is the role of atmospheric deposition in supplying vital nutrients to the phytoplankton that form the base of marine food webs. Industrial and vehicular pollution, wildfires, volcanoes, biogenic debris, and desert dust all carry nutrients within their plumes throughout the globe. In remote ocean ecosystems, aerosol deposition represents an essential new source of nutrients for primary production. The large spatiotemporal variability in aerosols from myriad sources combined with the differential responses of marine biota to changing fluxes makes it crucially important to understand where, when, and how much nutrients from the atmosphere enter marine ecosystems. This review brings together existing literature, experimental evidence of impacts, and new atmospheric nutrient observations that can be compared with atmospheric and ocean biogeochemistry modeling. We evaluate the contribution and spatiotemporal variability of nutrient-bearing aerosols from desert dust, wildfire, volcanic, and anthropogenic sources, including the organic component, deposition fluxes, and oceanic impacts. Expected final online publication date for the Annual Review of Marine Science, Volume 14 is January 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
    Print ISSN: 1941-1405
    Electronic ISSN: 1941-0611
    Topics: Biology , Geosciences
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  • 35
    Publication Date: 2021-08-20
    Description: When a phenological shift affects a demographic vital rate such as survival or reproduction, the altered vital rate may or may not have population-level consequences. We review the evidence that climate change affects populations by shifting species’ phenologies, emphasizing the importance of demographic life-history theory. We find many examples of phenological shifts having both positive and negative consequences for vital rates. Yet, few studies link phenological shifts to changes in vital rates known to drive population dynamics, especially in plants. When this link is made, results are largely consistent with life-history theory: Phenological shifts have population-level consequences when they affect survival in longer-lived organisms and reproduction in shorter-lived organisms. However, there are just as many cases in which demographic mechanisms buffer population growth from phenologically induced changes in vital rates. We provide recommendations for future research aiming to understand the complex relationships among climate, phenology, and demography, which will help to elucidate the extent to which phenological shifts actually alter population persistence. Expected final online publication date for the Annual Review of Ecology, Evolution, and Systematics, Volume 52 is November 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
    Print ISSN: 1543-592X
    Electronic ISSN: 1545-2069
    Topics: Biology
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  • 36
    Publication Date: 2021-08-20
    Description: Marine ecosystems are increasingly impacted by global environmental changes, including warming temperatures, deoxygenation, and ocean acidification. Marine scientists recognize intuitively that these environmental changes are translated into community changes via organismal physiology. However, physiology remains a black box in many ecological studies, and coexisting species in a community are often assumed to respond similarly to environmental stressors. Here, we emphasize how greater attention to physiology can improve our ability to predict the emergent effects of ocean change. In particular, understanding shifts in the intensity and outcome of species interactions such as competition and predation requires a sharpened focus on physiological variation among community members and the energetic demands and trophic mismatches generated by environmental changes. Our review also highlights how key species interactions that are sensitive to environmental change can operate as ecological leverage points through which small changes in abiotic conditions are amplified into large changes in marine ecosystems. Expected final online publication date for the Annual Review of Marine Science, Volume 14 is January 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
    Print ISSN: 1941-1405
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    Topics: Biology , Geosciences
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  • 37
    Publication Date: 2021-08-20
    Description: CRISPR-Cas adaptive immune systems in bacteria and archaea utilize short CRISPR RNAs (crRNAs) to guide sequence-specific recognition and clearance of foreign genetic material. Multiple crRNAs are stored together in a compact format called a CRISPR array that is transcribed and processed into the individual crRNAs. While the exact processing mechanisms vary widely, some CRISPR-Cas systems, including those encoding the Cas9 nuclease, rely on a trans-activating crRNA (tracrRNA). The tracrRNA was discovered in 2011 and was quickly co-opted to create single-guide RNAs as core components of CRISPR-Cas9 technologies. Since then, further studies have uncovered processes extending beyond the traditional role of tracrRNA in crRNA biogenesis, revealed Cas nucleases besides Cas9 that are dependent on tracrRNAs, and established new applications based on tracrRNA engineering. In this review, we describe the biology of the tracrRNA and how its ongoing characterization has garnered new insights into prokaryotic immune defense and enabled key technological advances. Expected final online publication date for the Annual Review of Genetics, Volume 55 is November 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
    Print ISSN: 0066-4197
    Electronic ISSN: 1545-2948
    Topics: Biology
    Published by Annual Reviews
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  • 38
    Publication Date: 2021-08-20
    Description: A small subset of marine microbial enzymes and surface transporters have a disproportionately important influence on the cycling of carbon and nutrients in the global ocean. As a result, they largely determine marine biological productivity and have been the focus of considerable research attention from microbial oceanographers. Like all biological catalysts, the activity of these keystone biomolecules is subject to control by temperature and pH, leaving the crucial ecosystem functions they support potentially vulnerable to anthropogenic environmental change. We summarize and discuss both consensus and conflicting evidence on the effects of sea surface warming and ocean acidification for five of these critical enzymes [carbonic anhydrase, ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO), nitrogenase, nitrate reductase, and ammonia monooxygenase] and one important transporter (proteorhodopsin). Finally, we forecast how the responses of these few but essential biocatalysts to ongoing global change processes may ultimately help to shape the microbial communities and biogeochemical cycles of the future greenhouse ocean. Expected final online publication date for the Annual Review of Marine Science, Volume 14 is January 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
    Print ISSN: 1941-1405
    Electronic ISSN: 1941-0611
    Topics: Biology , Geosciences
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  • 39
    Publication Date: 2021-08-20
    Description: State-owned investors (SOIs), including sovereign wealth funds and public pension funds, have $27 trillion in assets under management in 2020, making these funds the third largest group of asset owners globally. SOIs have become the largest and are among the most important private equity investors, and they are key investors in other alternative asset investments such as real estate, infrastructure, and hedge funds. SOIs are also leaders in promoting environmental, social, and governance policies and corporate social responsibility policies in investee companies. We document the rise of SOIs, assess their current investment policies, and describe how their state ownership both constrains and enhances their investment opportunity sets. We survey the most impactful recent academic research on sovereign wealth funds, public pension funds, and their closest financial analogs, private pension funds. We also introduce a new Governance-Sustainability-Resilience Scoreboard for SOIs and survey research examining their role in promoting good corporate governance. Expected final online publication date for the Annual Review of Financial Economics, Volume 13 is November 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
    Print ISSN: 1941-1367
    Electronic ISSN: 1941-1375
    Topics: Economics
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  • 40
    Publication Date: 2021-08-20
    Description: With the discovery of the incredible diversity of neurons, Cajal and coworkers laid the foundation of modern neuroscience. Neuron types are not only structural units of nervous systems but also evolutionary units, because their identities are encoded in the genome. With the advent of high-throughput cellular transcriptomics, neuronal identities can be characterized and compared systematically across species. The comparison of neurons in mammals, reptiles, and birds indicates that the mammalian cerebral cortex is a mosaic of deeply conserved and recently evolved neuron types. Using the cerebral cortex as a case study, this review illustrates how comparing neuron types across species is key to reconciling observations on neural development, neuroanatomy, circuit wiring, and physiology for an integrated understanding of brain evolution. Expected final online publication date for the Annual Review of Cell and Developmental Biology, Volume 37 is October 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
    Print ISSN: 1081-0706
    Electronic ISSN: 1530-8995
    Topics: Biology , Medicine
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  • 41
    Publication Date: 2021-08-20
    Description: A statistical model is a class of probability distributions assumed to contain the true distribution generating the data. In parametric models, the distributions are indexed by a finite-dimensional parameter characterizing the scientific question of interest. Semiparametric models describe the distributions in terms of a finite-dimensional parameter and an infinite-dimensional component, offering more flexibility. Ordinarily, the statistical model represents distributions for the full data intended to be collected. When elements of these full data are missing, the goal is to make valid inference on the full-data-model parameter using the observed data. In a series of fundamental works, Robins, Rotnitzky, and colleagues derived the class of observed-data estimators under a semiparametric model assuming that the missingness mechanism is at random, which leads to practical, robust methodology for many familiar data-analytic challenges. This article reviews semiparametric theory and the key steps in this derivation. Expected final online publication date for the Annual Review of Statistics, Volume 9 is March 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
    Print ISSN: 2326-8298
    Electronic ISSN: 2326-831X
    Topics: Mathematics
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  • 42
    Publication Date: 2021-08-20
    Description: For centuries, mathematicians and, later, statisticians, have found natural research and employment opportunities in the realm of insurance. By definition, insurance offers financial cover against unforeseen events that involve an important component of randomness, and consequently, probability theory and mathematical statistics enter insurance modeling in a fundamental way. In recent years, a data deluge, coupled with ever-advancing information technology and the birth of data science, has revolutionized or is about to revolutionize most areas of actuarial science as well as insurance practice. We discuss parts of this evolution and, in the case of non-life insurance, show how a combination of classical tools from statistics, such as generalized linear models and, e.g., neural networks contribute to better understanding and analysis of actuarial data. We further review areas of actuarial science where the cross fertilization between stochastics and insurance holds promise for both sides. Of course, the vastness of the field of insurance limits our choice of topics; we mainly focus on topics closer to our main areas of research. Expected final online publication date for the Annual Review of Statistics, Volume 9 is March 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
    Print ISSN: 2326-8298
    Electronic ISSN: 2326-831X
    Topics: Mathematics
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  • 43
    Publication Date: 2021-08-20
    Description: Aging is a major risk factor for multiple diseases. Understanding the underlying mechanisms of aging would help to delay and prevent age-associated diseases. Short-lived model organisms have been extensively used to study the mechanisms of aging. However, these short-lived species may be missing the longevity mechanisms that are needed to extend the lifespan of an already long-lived species such as humans. Unconventional long-lived animal species are an excellent resource to uncover novel mechanisms of longevity and disease resistance. Here, we review mechanisms that evolved in nonmodel vertebrate species to counteract age-associated diseases. Some antiaging mechanisms are conserved across species; however, various nonmodel species also evolved unique mechanisms to delay aging and prevent disease. This variety of antiaging mechanisms has evolved due to the remarkably diverse habitats and behaviors of these species. We propose that exploring a wider range of unconventional vertebrates will provide important resources to study antiaging mechanisms that are potentially applicable to humans. Expected final online publication date for the Annual Review of Genetics, Volume 55 is November 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
    Print ISSN: 0066-4197
    Electronic ISSN: 1545-2948
    Topics: Biology
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  • 44
    Publication Date: 2021-08-20
    Description: Studies of cetacean evolution using genetics and other biomolecules have come a long way—from the use of allozymes and short sequences of mitochondrial or nuclear DNA to the assembly of full nuclear genomes and characterization of proteins and lipids. Cetacean research has also advanced from using only contemporary samples to analyzing samples dating back thousands of years, and to retrieving data from indirect environmental sources, including water or sediments. Combined, these studies have profoundly deepened our understanding of the origin of cetaceans; their adaptation and speciation processes; and of the past population change, migration, and admixture events that gave rise to the diversity of cetaceans found today. Expected final online publication date for the Annual Review of Ecology, Evolution, and Systematics, Volume 52 is November 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
    Print ISSN: 1543-592X
    Electronic ISSN: 1545-2069
    Topics: Biology
    Published by Annual Reviews
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  • 45
    Publication Date: 2021-08-20
    Description: Many large marine predators make excursions from surface waters to the deep ocean below 200 m. Moreover, the ability to access meso- and bathypelagic habitats has evolved independently across marine mammals, reptiles, birds, teleost fishes, and elasmobranchs. Theoretical and empirical evidence suggests a number of plausible functional hypotheses for deep-diving behavior. Developing ways to test among these hypotheses will, however, require new ways to quantify animal behavior and biophysical oceanographic processes at coherent spatiotemporal scales. Current knowledge gaps include quantifying ecological links between surface waters and mesopelagic habitats and the value of ecosystem services provided by biomass in the ocean twilight zone. Growing pressure for ocean twilight zone fisheries creates an urgent need to understand the importance of the deep pelagic ocean to large marine predators. Expected final online publication date for the Annual Review of Marine Science, Volume 14 is January 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
    Print ISSN: 1941-1405
    Electronic ISSN: 1941-0611
    Topics: Biology , Geosciences
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  • 46
    Publication Date: 2021-02-25
    Print ISSN: 0022-3808
    Electronic ISSN: 1537-534X
    Topics: Economics
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  • 47
    Publication Date: 2021-02-25
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  • 48
    Publication Date: 2021-02-25
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  • 49
    Publication Date: 2021-02-25
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  • 50
    Publication Date: 2021-02-25
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  • 51
    Publication Date: 2021-02-25
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  • 52
    Publication Date: 2021-02-25
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  • 53
    Publication Date: 2021-02-25
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  • 54
    Publication Date: 2021-02-25
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  • 55
    Publication Date: 2021-02-25
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  • 56
    Publication Date: 2021-02-25
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  • 57
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  • 58
    Publication Date: 2021-02-25
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  • 59
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  • 60
    Publication Date: 2021-02-25
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  • 61
    Publication Date: 2021-02-25
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  • 62
    Publication Date: 2021-02-25
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  • 63
    Publication Date: 2021-02-25
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  • 64
    Publication Date: 2021-02-25
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  • 65
    Publication Date: 2021-02-25
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  • 66
    Publication Date: 2021-02-25
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  • 67
    Publication Date: 2021-02-25
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  • 68
    Publication Date: 2021-02-25
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  • 69
    Publication Date: 2021-02-25
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  • 70
    Publication Date: 2021-02-25
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  • 71
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  • 72
    Publication Date: 2021-02-25
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  • 73
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  • 74
    Publication Date: 2021-02-25
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  • 75
    Publication Date: 2021-02-25
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  • 77
    Publication Date: 2021-02-25
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  • 78
    Publication Date: 2021-02-25
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  • 80
    Publication Date: 2021-02-25
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  • 81
    Publication Date: 2021-02-25
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  • 82
    Publication Date: 2021-02-25
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  • 83
    Publication Date: 2021-02-25
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  • 84
    Publication Date: 2021-03-30
    Description: The faithful and timely copying of DNA by molecular machines known as replisomes depends on a disparate suite of enzymes and scaffolding factors working together in a highly orchestrated manner. Large, dynamic protein–nucleic acid assemblies that selectively morph between distinct conformations and compositional states underpin this critical cellular process. In this article, we discuss recent progress outlining the physical basis of replisome construction and progression in eukaryotes. Expected final online publication date for the Annual Review of Biochemistry, Volume 90 is June 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
    Print ISSN: 0066-4154
    Electronic ISSN: 1545-4509
    Topics: Biology , Chemistry and Pharmacology
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  • 85
    Publication Date: 2021-03-29
    Description: Microbiomes are complex and ubiquitous networks of microorganisms whose seemingly limitless chemical transformations could be harnessed to benefit agriculture, medicine, and biotechnology. The spatial and temporal changes in microbiome composition and function are influenced by a multitude of molecular and ecological factors. This complexity yields both versatility and challenges in designing synthetic microbiomes and perturbing natural microbiomes in controlled, predictable ways. In this review, we describe factors that give rise to emergent spatial and temporal microbiome properties and the meta-omics and computational modeling tools that can be used to understand microbiomes at the cellular and system levels. We also describe strategies for designing and engineering microbiomes to enhance or build novel functions. Throughout the review,we discuss key knowledge and technology gaps for elucidating the networks and deciphering key control points for microbiome engineering, and highlight examples where multiple omics and modeling approaches can be integrated to address these gaps. Expected final online publication date for the Annual Review of Biomedical Engineering, Volume 23 is June 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
    Print ISSN: 1523-9829
    Electronic ISSN: 1545-4274
    Topics: Medicine , Technology
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  • 86
    Publication Date: 2021-03-29
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  • 87
    Publication Date: 2021-03-29
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  • 88
    Publication Date: 2021-03-29
    Description: The remarkable diversity of specialized metabolites produced by plants has inspired several decades of research and nucleated a long list of theories to guide empirical ecological studies. However, analytical constraints and the lack of untargeted processing workflows have long precluded comprehensive metabolite profiling and, consequently, the collection of the critical currencies to test theory predictions for the ecological functions of plant metabolic diversity. Developments in mass spectrometry (MS) metabolomics have revolutionized the large-scale inventory and annotation of chemicals from biospecimens. Hence, the next generation of MS metabolomics propelled by new bioinformatics developments provides a long-awaited framework to revisit metabolism-centered ecological questions, much like the advances in next-generation sequencing of the last two decades impacted all research horizons in genomics. Here, we review advances in plant (computational) metabolomics to foster hypothesis formulation from complex metabolome data. Additionally, we reflect on how next-generation metabolomics could reinvigorate the testing of long-standing theories on plant metabolic diversity. Expected final online publication date for the Annual Review of Plant Biology, Volume 72 is May 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
    Print ISSN: 1543-5008
    Electronic ISSN: 1545-2123
    Topics: Biology
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  • 89
    Publication Date: 2021-03-29
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  • 90
    Publication Date: 2021-03-29
    Description: Optobiochemical control of protein activities allows the investigation of protein functions in living cells with high spatiotemporal resolution. Over the last two decades, numerous natural photosensory domains have been characterized and synthetic domains engineered and assembled into photoregulatory systems to control protein function with light.Here, we review the field of optobiochemistry, categorizing photosensory domains by chromophore, describing photoregulatory systems by mechanism of action, and discussing protein classes frequently investigated using optical methods. We also present examples of how spatial or temporal control of proteins in living cells has provided new insights not possible with traditional biochemical or cell biological techniques. Expected final online publication date for the Annual Review of Biochemistry, Volume 90 is June 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
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  • 91
    Publication Date: 2021-03-29
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  • 92
    Publication Date: 2021-03-29
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  • 93
    Publication Date: 2021-03-29
    Description: Codon-dependent translation underlies genetics and phylogenetic inferences, but its origins pose two challenges. Prevailing narratives cannot account for the fact that aminoacyl-tRNA synthetases (aaRSs), which translate the genetic code, must collectively enforce the rules used to assemble themselves. Nor can they explain how specific assignments arose from rudimentary differentiation between ancestral aaRSs and corresponding transfer RNAs (tRNAs). Experimental deconstruction of the two aaRS superfamilies created new experimental tools with which to analyze the emergence of the code. Amino acid and tRNA substrate recognition are linked to phase transfer free energies of amino acids and arise largely from aaRS class-specific differences in secondary structure. Sensitivity to protein folding rules endowed ancestral aaRS–tRNA pairs with the feedback necessary to rapidly compare alternative genetic codes and coding sequences. These and other experimental data suggest that the aaRS bidirectional genetic ancestry stabilized the differentiation and interdependence required to initiate and elaborate the genetic coding table. Expected final online publication date for the Annual Review of Biochemistry, Volume 90 is June 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
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  • 94
    Publication Date: 2021-03-29
    Description: Nucleosomes wrap DNA and impede access for the machinery of transcription. The core histones that constitute nucleosomes are subject to a diversity of posttranslational modifications, or marks, that impact the transcription of genes. Their functions have sometimes been difficult to infer because the enzymes that write and read them are complex, multifunctional proteins. Here, we examine the evidence for the functions of marks and argue that the major marks perform a fairly small number of roles in either promoting transcription or preventing it. Acetylations and phosphorylations on the histone core disrupt histone-DNA contacts and/or destabilize nucleosomes to promote transcription. Ubiquitylations stimulate methylations that provide a scaffold for either the formation of silencing complexes or resistance to those complexes, and carry a memory of the transcriptional state. Tail phosphorylations deconstruct silencing complexes in particular contexts. We speculate that these fairly simple roles form the basis of transcriptional regulation by histone marks. Expected final online publication date for the Annual Review of Genomics and Human Genetics Volume 22 is August 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
    Print ISSN: 1527-8204
    Electronic ISSN: 1545-293X
    Topics: Biology
    Published by Annual Reviews
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  • 95
    Publication Date: 2021-03-30
    Description: In 1961, Jacob and Monod proposed the operon model of gene regulation. At the model's core was the modular assembly of regulators, operators, and structural genes. To illustrate the composability of these elements, Jacob and Monod linked phenotypic diversity to the architectures of regulatory circuits. In this review, we examine how the circuit blueprints imagined by Jacob and Monod laid the foundation for the first synthetic gene networks that launched the field of synthetic biology in 2000. We discuss the influences of the operon model and its broader theoretical framework on the first generation of synthetic biological circuits, which were predominantly transcriptional and posttranscriptional circuits. We also describe how recent advances in molecular biology beyond the operon model—namely, programmable DNA- and RNA-binding molecules as well as models of epigenetic and posttranslational regulation—are expanding the synthetic biology toolkit and enabling the design of more complex biological circuits. Expected final online publication date for the Annual Review of Biochemistry, Volume 90 is June 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
    Print ISSN: 0066-4154
    Electronic ISSN: 1545-4509
    Topics: Biology , Chemistry and Pharmacology
    Published by Annual Reviews
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  • 96
    Publication Date: 2021-03-26
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 97
    Publication Date: 2021-03-26
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 98
    Publication Date: 2021-03-26
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 99
    Publication Date: 2021-03-26
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 100
    Publication Date: 2021-03-26
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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