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  • pharmacokinetics  (182)
  • Lepidoptera
  • growth
  • stability
  • Springer  (227)
  • Fischer
  • 1975-1979  (227)
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  • 1
    Digitale Medien
    Digitale Medien
    A secant method for multiple roots (1977)
    Springer
    BIT 17 (1977), S. 321-328 
    Details
    ISSN: 1572-9125
    Schlagwort(e): 5.15 ; nonlinear equation ; root finding ; multiple root ; secant method ; Steffensen procedure ; order of convergence ; efficiency ; stability
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Mathematik
    Notizen: Abstract A superlinear procedure for finding a multiple root is presented. In it the secant method is applied to the given function divided by a divided difference whose increment shrinks toward zero as the root is approached. Two function evaluations per step are required, but no derivatives need be calculated.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01932152
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Insect lysozymes from three species of lepidoptera: Their structural relatedness to the c (chicken) type lysozyme (1979)
    Springer
    Journal of molecular evolution 14 (1979), S. 267-271 
    Details
    ISSN: 1432-1432
    Schlagwort(e): Lysozyme ; Insect ; Lepidoptera ; Evolution ; Sequence
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Summary Sequence studies of the N-terminal halves of the lysozymes isolated fromBombyx mori, Galleria mellonella andSpodoptera littoralis (Lepidoptera) allow us to classify these enzymes among the c (chicken) type lysozymes.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01732494
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  • 3
    Digitale Medien
    Digitale Medien
    Macroscopic behavior of a quantum monomode laser (1976)
    Springer
    Journal of statistical physics 14 (1976), S. 399-416 
    Details
    ISSN: 1572-9613
    Schlagwort(e): Reservoir-driven open systems ; coherent states ; entropy production ; nonlinear equations ; irreversible processes ; stationary state ; stability
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Abstract A kinetic equation for the density matrix of a monomode laser with explicit coupling with a thermal reservoir representing the cavity and a nonthermal one representing the pumping mechanism is derived. The macroscopic behavior of this system, inferred from Glauber's P function, is discussed within the framework of Glansdorff-Prigogine's theory of far-from-thermal-equilibrium open systems.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01040701
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  • 4
    Digitale Medien
    Digitale Medien
    Über den Einfluß der Kulturdauer im larvalen Wirt auf die Entwicklungsleistungen implantierter männlicher Genitalimaginalscheiben vonEphestia, kuehniella Z. (1979)
    Springer
    Development genes and evolution 186 (1979), S. 309-331 
    Details
    ISSN: 1432-041X
    Schlagwort(e): Lepidoptera ; Male genital disk ; Implantation ; Regeneration ; Control of metamorphosis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Summary Complete and bisected male genital disks (HO) from full-grown (T9) larvae were transplanted either into larvae and pharate pupae of different age (T4, T7, T9 larvae, A1–A5 pharate pupae) or repeatedly transferred into full-grown larvae before being implanted into a final larval host. After metamorphosis of the hosts, most of the complete transplants and regenerated HO halves showed normal morphological features, but the implanted genitals from old pharate pupae (A4 and A5) were abnormally differentiated. Frequency of Regeneration. After transplanting both halves of the bisected HO into T9 hosts, three groups of results were observed: (1) each of the two halves regenerated into a complete genital organ; (2) only one half regenerated; (3) neither of the two halves regenerated. In the pharate pupae no regeneration of the implanted halves took place. If the lapse of time between the transplantation and, the onset of metamorphosis (=onset of pharate pupae phase) was long enough by transplanting into young larvae (T4) or by repeatedly transferring into old larvae and subsequent transplantation into a final larval host, all the implanted halves were able to regenerate. Size of the Implanted Genital Organs After prolonging the in vivo culture in larval hosts by implanting into young larvae or repeatedly transferring into old larvae, it was found that the regenerated genitalia grew to the same size as the complete transplants, but the size of the complete transplants increased, if at all, only insignificantly. Duration of Development of the Hosts. Regeneration of one HO half implanted into a full-grown larva caused an average delay of further development of about 2 days. An additional delay was recorded when both halves had regenerated. However, no delay was observed when HO halves implanted into young (T4) larvae regenerated, and no delay occurred in the final hosts when the repeatedly transferred halves had reached a certain stage of regeneration. The developmental capacities of the tranplanted disks and the control of metamorphosis by regenerating disks are discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00848456
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  • 5
    Digitale Medien
    Digitale Medien
    Pharmacokinetics of di-n-propylacetate in epileptic patients (1975)
    Springer
    European journal of clinical pharmacology 8 (1975), S. 97-105 
    Details
    ISSN: 1432-1041
    Schlagwort(e): Di-n-propylacetate ; 2-propyl-valeric acid sodium salt ; pharmacokinetics ; anti-epileptic ; drug monitoring ; man
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary The pharmacokinetics of the anti-epileptic drug di-n-propylacetate (DepakineR) have been studied in 7 patients, in whom plasma concentrations were determined during and following subchronic treatment. Elimination of the drug appeared to follow a monophasic exponential course; biological half lives were 8 to 15 hours. The data supported the assumption that an open one-compartment model can be used to describe the kinetics of dipropylacetate in man. The drug appeared to have a relatively restricted distribution: calculated relative distribution volumes ranged from 0.15 to 0.40 1/kg. There were large interindividual differences in clearance rate. The therapeutic range was considered to be between 50 and 100 mg/1 plasma. Plasma levels of phenobarbital were markedly raised during treatment with dipropylacetate for an unknown reason. Determination of the plasma concentrations of drugs at accurately fixed times appears to be a reliable method for pharmacotherapeutic monitoring of epileptic patients.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00561557
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  • 6
    Digitale Medien
    Digitale Medien
    Concentrations of the vasodilator isosorbide dinitrate and its metabolites in the blood of human subjects (1975)
    Springer
    European journal of clinical pharmacology 8 (1975), S. 157-160 
    Details
    ISSN: 1432-1041
    Schlagwort(e): Isosorbide dinitrate ; pharmacokinetics ; metabolism ; pharmacological action ; nitrates
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary An oral dose of 5 mg of14C-isosorbide dinitrate was rapidly absorbed, biotransformed and excreted by human subjects. Peak whole blood concentrations of radioactivity were reached after 1.5 to 2 hours and declined relatively slowly. The radioactivity in whole blood mainly represented metabolites, isosorbide mononitrates. The peak concentrations found were 4.5, 11.7 and 34.3 ng/ml of isosorbide dinitrate, isosorbide 2-mononitrate and isosorbide 5-mononitrate, respectively, in the blood of one subject and 5.9, 15 and 61.3 ng/ml, respectively, in the blood of another subject. However, concentrations of the metabolites declined relatively slowly during 6 h after the oral dose. Up to 99% of an oral dose of isosorbide dinitrate was excreted during 5 days, mainly in the urine of the first day (ca. 78%). The results showed that isosorbide mononitrates were available to contribute to the pharmacological action.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00567108
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  • 7
    Digitale Medien
    Digitale Medien
    Pharmacokinetics — Uses and abuses (1975)
    Springer
    European journal of clinical pharmacology 8 (1975), S. 241-248 
    Details
    ISSN: 1432-1041
    Schlagwort(e): pharmacokinetics ; experimental design
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary It is apparent from studying recent articles on pharmacokinetics that a number of misunder-standings exist, both about the design of experiments and the analysis of results. The purpose of this paper is to outline many of the common pitfalls associated with the design of experiments and also the limitations upon the analysis of results. The paper describes mathematical, laboratory and clinical aspects which must be examined in designing a protocol for pharmacokinetic experiments. Simulated data is presented to demonstrate the dangers of using standard computer programs for parameter estimation. Even when convergence is obtained the answers may be dependent on the method employed. A mathematical model is of little use unless a reasonable amount of good, accurate data is obtained.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00567122
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  • 8
    Digitale Medien
    Digitale Medien
    Pharmacokinetics and side-effects of clonazepam and its 7- amino-metabolite in man (1975)
    Springer
    European journal of clinical pharmacology 8 (1975), S. 249-254 
    Details
    ISSN: 1432-1041
    Schlagwort(e): Clonazepam ; 7-amino-clonazepam ; pharmacokinetics ; side-effects ; man
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary Clonazepam (CNP) and its principal metabolite in plasma, 7-amino-CNP (ACNP), have been investigated in a prospective study of 27 newly diagnosed epileptics and correlated with specified side-effects. At a daily dose of 6 mg, the average plasma levels of both substances were about 50ng/ml, and individual values ranged from 30 to about 80ng/ml. There was a linear correlation between changes in dose and the resulting plasma levels, which indicates first order elimination kinetics. Side-effects were frequent, but neither their severity nor their occurrence could be related to plasma levels or to the rate of increase in plasma concentration of the drug. Three out of five patients who developed serious dysphoria had significantly high CNP levels. The concentration of ACNP was considerably increased in four patients who subsequently suffered from withdrawal symptoms. Drug interaction with diphenylhydantoin, i.e. decreased CNP level, was observed in all five patients who received both compounds. In general it is not yet possible to define an upper limit for the plasma levels of CNP and ACNP at which toxicity occurs. In patients treated with conventional doses of CNP, measurement of plasma concentration is not required, except in special circumstances, because of the lack of correlation between plasma level and side-effects.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00567123
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  • 9
    Digitale Medien
    Digitale Medien
    Anticoagulant effect and plasma kinetics of fluorophenindione after a single dose in man (1975)
    Springer
    European journal of clinical pharmacology 8 (1975), S. 271-275 
    Details
    ISSN: 1432-1041
    Schlagwort(e): Fluorophenindione ; vitamin K antagonist ; pharmacokinetics ; loading dose ; anticoagulant
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary After administration of a single loading dose (80 mg p.o.) of fluorophenindione, the prothrombin level decreased to 37 % in 24 h, and the effect lasted for 48 h. Accordingly, fluorophenindione can be classified as an anticoagulant with an “intermediate” effect. Its elimination half-life was 31 h, which is longer than that of phenindione, because of the greater stability of the fluorinated derivate.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00567127
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  • 10
    Digitale Medien
    Digitale Medien
    Kinetics of nortriptyline in man according to a two compartment model (1975)
    Springer
    European journal of clinical pharmacology 8 (1975), S. 343-347 
    Details
    ISSN: 1432-1041
    Schlagwort(e): Nortriptyline ; pharmacokinetics ; man ; two compartment model
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary Plasma concentrations of nortriptyline have been assayed in four subjects after intravenous infusion of 57 mg nortriptyline hydrochloride. The data were evaluated according to a two compartment open model. The calculated best-fitting curves were in good agreement with the experimental data, better than could be expected from a simpler model. This justifies the assumption that the kinetics of nortriptyline in man may be described by this model with an appropriate input function. The data permitted estimation of all the parameters of the model. The meaning of the parameters is discussed, particularly in relation to individual variation.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00562660
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