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  • Base Sequence
  • Signal Transduction
  • American Association for the Advancement of Science (AAAS)  (25)
  • American Institute of Physics (AIP)
  • 1975-1979  (25)
Collection
Keywords
Publisher
  • American Association for the Advancement of Science (AAAS)  (25)
  • American Institute of Physics (AIP)
Years
Year
  • 1
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    The genome of simian virus 40 (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-05-05
    Description: The nucleotide sequence of SV40 DNA was determined, and the sequence was correlated with known genes of the virus and with the structure of viral messenger RNA's. There is a limited overlap of the coding regions for structural proteins and a complex pattern of leader sequences at the 5' end of late messenger RNA. The sequence of the early region is consistent with recent proposals that the large early polypeptide of SV40 is encoded in noncontinguous segments of DNA.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Reddy, V B -- Thimmappaya, B -- Dhar, R -- Subramanian, K N -- Zain, B S -- Pan, J -- Ghosh, P K -- Celma, M L -- Weissman, S M -- New York, N.Y. -- Science. 1978 May 5;200(4341):494-502.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/205947" target="_blank"〉PubMed〈/a〉
    Keywords: Base Sequence ; Chromosome Mapping ; Codon ; DNA Replication ; DNA, Circular ; DNA, Viral ; Genes ; *Genes, Viral ; Simian virus 40/*genetics ; Transcription, Genetic ; Viral Proteins/genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Origins of prokaryotes, eukaryotes, mitochondria, and chloroplasts (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-01-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schwartz, R M -- Dayhoff, M O -- New York, N.Y. -- Science. 1978 Jan 27;199(4327):395-403.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/202030" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Base Sequence ; *Biological Evolution ; *Cells ; *Chloroplasts ; Computers ; Cytochrome c Group ; *Eukaryotic Cells ; Ferredoxins ; *Mitochondria ; Nucleic Acids ; *Prokaryotic Cells ; Proteins ; RNA, Ribosomal
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Antibody diversity (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-10-06
    Description: Three important aspects of immunoglobulin gene organization and structure have emerged from studies of cloned immunoglobulin kappa chain genes. (i) Multiple variable genes are encoded separately in the genome of both immunoglobulin-producing and uncommitted (embryonic) cells, thereby establishing the evolutionary base for generating immunoglobulin diversity. (ii) These genes exist as many small, closely related families (subgroups) that share close sequence homology largely within their own subgroup. (iii) Comparison of two cloned variable gene segments derived from a single subgroup reveals a feature of their structure that distinguishes them from fixed genes (that is, globin genes) and provides, through extensive surrounding sequence homology, a large target for intergenic recombination. This last observation suggests that a simple recombination mechanism may account for their genetic instability in both germ line and somatic cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Seidman, J G -- Leder, A -- Nau, M -- Norman, B -- Leder, P -- New York, N.Y. -- Science. 1978 Oct 6;202(4363):11-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/99815" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Antibody Specificity ; Base Sequence ; Binding Sites, Antibody/*genetics ; Biological Evolution ; Cell Line ; Embryo, Mammalian/immunology ; *Genes ; Immunoglobulin Constant Regions/*genetics ; Immunoglobulin Light Chains/*genetics ; Immunoglobulin Variable Region/*genetics ; Immunoglobulin kappa-Chains/*genetics ; Immunoglobulins/*genetics ; Mice ; Neoplasms, Experimental/immunology ; Plasmacytoma/immunology ; Recombination, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Regulation of gene expression: possible role of repetitive sequences (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-06-08
    Description: Large contrasts are observed between the messenger RNA populations of different tissues and of embryos at different stages of development. Nevertheless, coding sequences for genes not expressed in a cell appear to be present in its nuclear RNA. Though many nuclear RNA transcripts of single copy DNA sequences are held in common between tissues, an additional set, probably consisting of non-message sequences, is not shared. Nuclear RNA also contains transcripts of repetitive DNA sequences. Certain repeat families are represented at high levels in the nuclear RNA of particular tissues and much lower levels in others. It is surprising that both complements of most repeat sequences are present in nuclear RNA. These observations lead to model for regulation of gene expression in which the formation of repetitive RNA-RNA duplexes controls the production of messenger RNA.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Davidson, E H -- Britten, R J -- New York, N.Y. -- Science. 1979 Jun 8;204(4397):1052-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451548" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Cell Nucleus/physiology ; DNA/*genetics ; Genes ; *Genes, Regulator ; Hydrogen Bonding ; Mammals/embryology ; Models, Biological ; Polyribosomes/metabolism ; *RNA, Heterogeneous Nuclear/genetics ; RNA, Messenger/genetics ; Sea Urchins/embryology ; *Transcription, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Viroids: structure and function (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-31
    Description: Viroids are nucleic acid species of relatively low molecular weight and unique structure that cause several important diseases of cultivated plants. Similar nucleic acid species may be responsible for certain diseases of animals and humans. Viroids are the smallest known agents of infectious disease. Unlike viral nucleic acids, viroids are not encapsidated. Despite their small size, viroids replicate autonomously in cells of susceptible plant species. Known viroids are single-stranded, covalently closed circular, as well as linear, RNA molecules with extensive regions of intramolecular complementarity; they exist in their native state as highly base-paired rods.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Diener, T O -- New York, N.Y. -- Science. 1979 Aug 31;205(4409):859-66.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472709" target="_blank"〉PubMed〈/a〉
    Keywords: Base Sequence ; DNA, Viral/genetics ; Molecular Weight ; Nucleic Acid Conformation ; Plant Viruses/*genetics/isolation & purification/ultrastructure ; RNA, Viral/*genetics ; Templates, Genetic ; Virus Replication
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    Total synthesis of a gene (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-02-16
    Description: The method developed for the total synthesis of a given DNA containing biologically specific sequences consists of the following. The DNA in the double-stranded form is carefully divided into short single-stranded segments with suitable overlaps in the complementary strands. All the segments are chemically synthesized starting with protected nucleosides and mononucleotides. The 5'-OH ends of the appropriate oligonucleotides are then phosphorylated with the use of [y-32P]ATP and polynucleotide kinase. A few to several neighboring oligonucleotides are then allowed to form bihelical complexes in aqueous solution, and the latter are joined end to end by polynucleotide ligase to form covalently linked duplexes. Subsequent heat-to-tail joining of the short duplexes leads to the total DNA. The methods are described for the construction of a biologically functional suppressor transfer RNA gene. The total work involved (i) the synthesis of a 126-nucleotide-long bihelical DNA corresponding to a known precursor to the tyrosine suppressor transfer RNA, (ii) the sequencing of the promoter region and the distal region adjoining the C-C-A end, which contained a signal for the processing of the RNA transcript, (iii) total synthesis of the 207 base-pair-long DNA, which included the control elements, as well as the Eco R1 restriction endonuclease specific sequences at the two ends, and (iv) full characterization by transcription in vitro and amber suppressor activity in vivo of the synthetic gene.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Khorana, H G -- New York, N.Y. -- Science. 1979 Feb 16;203(4381):614-25.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/366749" target="_blank"〉PubMed〈/a〉
    Keywords: Base Sequence ; DNA, Recombinant ; DNA-Directed RNA Polymerases/metabolism ; Escherichia coli/genetics ; *Genes ; Genes, Regulator ; Hydrogen Bonding ; Nucleic Acid Conformation ; Oligodeoxyribonucleotides/*chemical synthesis ; Oligonucleotides/*chemical synthesis ; RNA, Transfer/*genetics ; Suppression, Genetic ; Transcription, Genetic ; Tyrosine
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    DNA organization of Methanobacterium thermoautotrophicum (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-06-08
    Description: The organism Methanobacterium thermoautotrophicum, an archaebacterium, is envolutionarily very distant from both traditional prokaryotes and eukaryotes. Its genome (DNA) has physical characteristics typical of most prokaryotes except that it is quite small (about 10(9) daltons, less than half the size of the genome of Escherichia coli) and contains a significant amount (6 percent) DNA which renatures extremely rapidly.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mitchell, R M -- Loeblich, L A -- Klotz, L C -- Loeblich, A R 3rd -- New York, N.Y. -- Science. 1979 Jun 8;204(4397):1082-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/377486" target="_blank"〉PubMed〈/a〉
    Keywords: Base Sequence ; Biological Evolution ; DNA, Bacterial/*genetics ; Escherichia coli/genetics ; Euryarchaeota/classification/*genetics ; Nucleic Acid Renaturation
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    Structure of the constant and 3' untranslated regions of the murine gamma 2b heavy chain messenger RNA (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-14
    Description: The complete coding sequence for the constant region of the mouse gamma 2b immunoglobulin heavy chain and the 3' untranslated region has been determined. The coding portion of the sequence is 1008 nucleotides long (amino acid residues 114 to 449), and the 3' noncoding region contains 102 nucleotides preceeding the polyadenylate. An extra carboxyl-terminal lysine residue which had not been observed in the gamma 2b or other gamma subclass protein sequences occurs in the nucleotide sequence and is probably processed posttranslationally. A 17-nucleotide sequence occurs with slight variation twice in CH1 and once in CH2 domains in the same relative location but with different translational phase. This sequence may be the site of crossover in a gamma 2b . gamma 2a heavy chain variant, an indication of possible recombinational activity of some kind.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tucker, P W -- Marcu, K B -- Slightom, J L -- Blattner, F R -- New York, N.Y. -- Science. 1979 Dec 14;206(4424):1299-303.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/117548" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Biological Evolution ; Codon ; DNA, Recombinant ; Immunoglobulin Constant Regions/*genetics ; Immunoglobulin Heavy Chains/*genetics ; Immunoglobulin gamma-Chains/*genetics ; Immunoglobulins/*genetics ; Mice ; *Protein Biosynthesis ; RNA, Messenger/*genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    Implications of RNA-RNA splicing in evolution of eukaryotic cells (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-12-22
    Description: The differences in the biochemistry of messenger RNA formation in eukaryotes compared to prokaryotes are so profound as to suggest that sequential prokaryotic to eukaryotic cell evolution seems unlikely. The recently discovered noncontiguous sequences in eukaryotic DNA that encode messenger RNA may reflect an ancient, rather than a new, distribution of information in DNA and that eukaryotes evolved independently of prokaryotes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Darnell, J E Jr -- New York, N.Y. -- Science. 1978 Dec 22;202(4374):1257-60.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/364651" target="_blank"〉PubMed〈/a〉
    Keywords: Adenoviruses, Human/genetics ; Base Sequence ; *Biological Evolution ; Eukaryotic Cells/physiology ; *Genes ; Prokaryotic Cells/physiology ; RNA, Messenger/*genetics ; RNA, Transfer/genetics ; RNA, Viral/genetics ; Recombination, Genetic ; Saccharomyces cerevisiae/genetics ; Transcription, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    The 1978 Nobel prize in physiology or medicine (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-12-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Linn, S -- New York, N.Y. -- Science. 1978 Dec 8;202(4372):1069-71.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/362532" target="_blank"〉PubMed〈/a〉
    Keywords: *Awards and Prizes ; Base Sequence ; *DNA Restriction Enzymes/history/metabolism ; DNA, Recombinant ; Genetic Engineering ; History, 20th Century ; R Factors ; Substrate Specificity
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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