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  • United States  (110)
  • Cell Line  (35)
  • American Association for the Advancement of Science (AAAS)  (145)
  • American Association of Petroleum Geologists (AAPG)
  • Bonn: Institute of Labor Economics (IZA)
  • The International Collective in Support of Fishworkers (ICSF)
  • 1975-1979  (145)
Collection
Keywords
Publisher
  • American Association for the Advancement of Science (AAAS)  (145)
  • American Association of Petroleum Geologists (AAPG)
  • Bonn: Institute of Labor Economics (IZA)
  • The International Collective in Support of Fishworkers (ICSF)
  • Springer  (2)
Years
Year
  • 1
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    New strength in the diet-disease link? (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Broad, W J -- New York, N.Y. -- Science. 1979 Nov 9;206(4419):666-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493971" target="_blank"〉PubMed〈/a〉
    Keywords: Diet/*adverse effects ; Disease/*etiology ; Humans ; Legislation as Topic ; National Institutes of Health (U.S.) ; Nutritional Physiological Phenomena ; Peer Review ; Preventive Medicine/methods ; Research Support as Topic ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    NIH deals gingerly with diet-disease link (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-06-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Broad, W J -- New York, N.Y. -- Science. 1979 Jun 15;204(4398):1175-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451563" target="_blank"〉PubMed〈/a〉
    Keywords: Diabetes Mellitus/etiology ; Diet/*adverse effects ; Disease/*etiology ; *National Institutes of Health (U.S.) ; Neoplasms/etiology ; *Nutritional Physiological Phenomena ; Preventive Medicine ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Approval sought for nerve gas pilot plant (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carter, L J -- New York, N.Y. -- Science. 1979 Dec 7;206(4423):1164, 1166.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/504999" target="_blank"〉PubMed〈/a〉
    Keywords: *Chemical Warfare Agents ; Containment of Biohazards ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Dispute over cancer risk quantification (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-03-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carter, L J -- New York, N.Y. -- Science. 1979 Mar 30;203(4387):1324-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/106470" target="_blank"〉PubMed〈/a〉
    Keywords: Benzene/*toxicity ; *Carcinogens ; Cost-Benefit Analysis ; Environmental Exposure ; Government Agencies ; Legislation, Drug ; Risk ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Headache for Bristol-Myers (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1979 Nov 2;206(4418):540-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493959" target="_blank"〉PubMed〈/a〉
    Keywords: Advertising as Topic/standards ; Analgesics/*standards ; Aspirin/*standards ; Drug Industry/*standards ; Jurisprudence ; Nonprescription Drugs/*standards ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Thiourea reverses cross-links and restores biological activity in DNA treated with dichlorodiaminoplatinum (II) (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-04-13
    Description: Cis and trans dichlorodiaminoplatinum (II) compounds bind to DNA and form DNA cross-links, which are usually considered to be irreversible. Thiourea can reverse these cross-links without any apparent breakdown of the DNA. In addition, cis- and trans-Pt (II) treatment of lambda decreases its transfectivity. After suitable incubation with thiourea, full transfectivity of Pt(II)-treated lambda DNA can be restored.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Filipski, J -- Kohn, K W -- Prather, R -- Bonner, W M -- New York, N.Y. -- Science. 1979 Apr 13;204(4389):181-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/571145" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Coliphages ; DNA/*metabolism ; DNA, Neoplasm/metabolism ; DNA, Viral/metabolism ; Leukemia L1210 ; Organoplatinum Compounds/*antagonists & inhibitors ; Structure-Activity Relationship ; Thiourea/*pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    Basic research in the United States (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-05-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Handler, P -- New York, N.Y. -- Science. 1979 May 4;204(4392):474-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/432651" target="_blank"〉PubMed〈/a〉
    Keywords: Astronomy/history ; Biology/history ; Chemistry/history ; Environment ; Government Agencies/history ; History, 20th Century ; Physics/history ; *Research Support as Topic ; Science/*history ; Social Sciences/history ; United States ; Universities/history/manpower
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 8
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    Environmental health research (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hiatt, H H -- New York, N.Y. -- Science. 1979 Dec 21;206(4425):1361.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/505011" target="_blank"〉PubMed〈/a〉
    Keywords: *Environmental Health ; Research ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 9
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    Genetic mechanism accounting for precise immunoglobulin domain deletion in a variant of MPC 11 myeloma cells (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-14
    Description: A variant of the MPC 11 cell line, M 311, produces a short immunoglobulin heavy chain. When compared with the parental gamma 2b heavy chain, M 311 was found to have a carboxyl terminal deletion comprising the CH3 domain. The COOH-terminal cyanogen bromide (CNBr) cleavage fragment of M 311 is identical to a corresponding segment ofa parental heavy chain CNBr fragment, with the exception of a substitution of asparagine for lysine at the COOH-terminal residue. This observation enabled prediction of both the parental DNA sequence in this region and the genetic mechanism which generated the variant, a frameshift followed by premature termination. This hypothesis is supported by studies of the DNA sequence of the MPC 11 gamma 2b constant region gene.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kenter, A L -- Birshtein, B K -- R21 AI106328/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1979 Dec 14;206(4424):1307-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/117550" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Chromosome Deletion ; Genes ; Immunoglobulin G/*genetics ; Immunoglobulin gamma-Chains/genetics ; Macromolecular Substances ; Melphalan/pharmacology ; Mice ; Mutation ; Myeloma Proteins/*genetics ; Neoplasms, Experimental/genetics ; Peptide Chain Termination, Translational ; Plasmacytoma/genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    Laboratory animal feed (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-06-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Knapka, J J -- New York, N.Y. -- Science. 1979 Jun 29;204(4400):1367.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/582217" target="_blank"〉PubMed〈/a〉
    Keywords: Animal Feed/*analysis ; Animals ; Animals, Laboratory ; Hot Temperature ; National Institutes of Health (U.S.) ; Nitrosamines/analysis ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 11
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    Large drug firms fight generic substitution (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G B -- New York, N.Y. -- Science. 1979 Nov 30;206(4422):1054-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493991" target="_blank"〉PubMed〈/a〉
    Keywords: Costs and Cost Analysis ; Drug Industry/*economics ; Legislation, Drug ; *Therapeutic Equivalency ; United States ; United States Food and Drug Administration
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 12
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    The phenformin ban: is the drug an imminent hazard? (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-03-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G B -- New York, N.Y. -- Science. 1979 Mar 16;203(4385):1094-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/424735" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; Lactates/blood ; Legislation, Drug ; Phenformin/adverse effects/*standards ; United States ; United States Dept. of Health and Human Services ; United States Food and Drug Administration
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 13
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    New drugs and the brain (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G B -- New York, N.Y. -- Science. 1979 Aug 24;205(4408):774-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/379998" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; France ; History, 20th Century ; Humans ; Mice ; Psychotropic Drugs/*history/metabolism/therapeutic use ; Rats ; Schizophrenia/drug therapy ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 14
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    Controversy over study of diabetes drugs continues for nearly a decade (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-03-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G B -- New York, N.Y. -- Science. 1979 Mar 9;203(4384):986-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/370980" target="_blank"〉PubMed〈/a〉
    Keywords: Cardiovascular Diseases/chemically induced ; Clinical Trials as Topic ; Diabetes Mellitus/*drug therapy ; Drug Information Services ; History, 20th Century ; Humans ; Hypoglycemic Agents/adverse effects/history/*standards ; Jurisprudence ; Legislation, Drug/*history ; Phenformin/adverse effects ; Research Design/standards ; Tolbutamide/adverse effects ; United States ; United States Food and Drug Administration/history
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 15
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    Panel urges wide use of antiviral drug (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maugh, T H 2nd -- New York, N.Y. -- Science. 1979 Nov 30;206(4422):1058-60.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/386515" target="_blank"〉PubMed〈/a〉
    Keywords: Amantadine/history/*therapeutic use ; History, 20th Century ; Humans ; Influenza A virus ; Influenza, Human/prevention & control/*therapy ; National Institutes of Health (U.S.) ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 16
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    NAS study on radiation takes the middle road (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-05-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1979 May 18;204(4394):711, 713-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/441736" target="_blank"〉PubMed〈/a〉
    Keywords: Congenital Abnormalities/etiology ; Dose-Response Relationship, Radiation ; Humans ; Maximum Allowable Concentration ; Neoplasms, Radiation-Induced/etiology ; Radiation Injuries/*etiology ; Risk ; Societies, Scientific ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 17
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    NCI bioassays (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shubik, P -- Clayson, D B -- New York, N.Y. -- Science. 1979 Aug 24;205(4408):746, 748.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/462187" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Carcinogens ; *Drug Evaluation, Preclinical ; *National Institutes of Health (U.S.) ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 18
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    NCI bioassays yield a trail of blunders (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-06-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, R J -- New York, N.Y. -- Science. 1979 Jun 22;204(4399):1287-92.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451534" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Assay/methods ; *Carcinogens ; Legislation as Topic ; Mice ; *National Institutes of Health (U.S.) ; Research Design/standards ; Research Support as Topic ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 19
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    Government-university relations (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-06-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pings, C J -- New York, N.Y. -- Science. 1979 Jun 15;204(4398):1158.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451562" target="_blank"〉PubMed〈/a〉
    Keywords: Government Agencies ; *Research Support as Topic ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 20
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    Surgeon general seeks physicians' help in DES alert (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-01-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1979 Jan 12;203(4376):159.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/758685" target="_blank"〉PubMed〈/a〉
    Keywords: Diethylstilbestrol/*adverse effects ; Drug Information Services ; Female ; Government Agencies ; Humans ; Mesonephroma/*chemically induced ; United States ; Vaginal Neoplasms/*chemically induced
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 21
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    It could have been worse for R & D in Carter's "austerity" budget (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-02-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1979 Feb 2;203(4379):416-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/760199" target="_blank"〉PubMed〈/a〉
    Keywords: Government ; Research Support as Topic/*economics ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 22
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    Canine Babesia new to North America (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-06-29
    Description: A domestic dog residing in New England suffered a fatal febrile illness caused by a Babesia infection. The morphology of these intraerythrocytic protozoa and the range of hosts that could be infected experimentally suggested that the parasite was B. gibsoni. Although this tick-bourne disease is enzootic in wild and domestic Canidae in Africa and Asia, it appears to be new to the Americas.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Anderson, J F -- Magnarelli, L A -- Donner, C S -- Spielman, A -- Piesman, J -- New York, N.Y. -- Science. 1979 Jun 29;204(4400):1431-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451574" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arthropod Vectors ; Babesia/classification/cytology ; Babesiosis/epidemiology/*parasitology/transmission ; Cricetinae ; Dog Diseases/*parasitology ; Dogs ; Erythrocytes/parasitology ; Mice ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 23
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    Jump in funding feeds research on nutrition (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-06-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Broad, W J -- New York, N.Y. -- Science. 1979 Jun 8;204(4397):1060-1, 1063-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451549" target="_blank"〉PubMed〈/a〉
    Keywords: *Diet ; Disease ; Government Agencies ; Humans ; Legislation as Topic ; *Nutritional Physiological Phenomena ; Research Support as Topic ; United States ; United States Dept. of Health and Human Services
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Yearly report on carcinogens could be a potent weapon in the war on cancer (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-02-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carter, L J -- New York, N.Y. -- Science. 1979 Feb 9;203(4380):525-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/760203" target="_blank"〉PubMed〈/a〉
    Keywords: *Carcinogens ; Dose-Response Relationship, Drug ; Government Agencies ; Humans ; Legislation, Drug ; Neoplasms/*prevention & control ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 25
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    Radioactive waste policy is in disarray (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-10-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carter, L J -- New York, N.Y. -- Science. 1979 Oct 19;206(4416):312-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/482940" target="_blank"〉PubMed〈/a〉
    Keywords: Government Agencies ; Legislation as Topic ; *Radioactive Waste ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 26
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    Permeability of the cell-to-cell membrane channels in mammalian cell juncton (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-07-27
    Description: The channels in the junctions of various mammalian cell types--primary cultures and lines--were probed with a series of linear fluorescent amino acid and peptide molecules of different size and charge. Permeability is limited by probe size and electronegativity, these two factors apparently being related reciprocally. In respect to both factors, mammalian junctional channels are more restrictive than insect channels; hence the mammalian channels are narrower, more polar, or both. The channels of the various mammalian cell types differed slightly from each other; in some types the serum of the culture medium affected the channel permeability.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Flagg-Newton, J -- Simpson, I -- Loewenstein, W R -- New York, N.Y. -- Science. 1979 Jul 27;205(4404):404-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/377490" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Cell Membrane/physiology ; *Cell Membrane Permeability ; Cells, Cultured ; Cricetinae ; Fluorescent Antibody Technique ; Kidney ; Mice ; Mice, Inbred BALB C ; Species Specificity
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 27
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    Public policy and health manpower (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-05-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fordham, C C 3rd -- New York, N.Y. -- Science. 1979 May 4;204(4392):459.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/432650" target="_blank"〉PubMed〈/a〉
    Keywords: Education, Medical ; Physicians/*supply & distribution ; *Public Policy ; United States ; United States Dept. of Health and Human Services
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 28
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    Toxic waste disposal a growing problem (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-05-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maugh, T H 2nd -- New York, N.Y. -- Science. 1979 May 25;204(4395):819-23.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/441738" target="_blank"〉PubMed〈/a〉
    Keywords: Economics ; Environmental Pollutants/*adverse effects ; Government ; Jurisprudence ; Legislation as Topic ; *Refuse Disposal ; *Sewage ; United States ; *Waste Disposal, Fluid
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  • 29
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    NCI bioassay program (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Upton, A C -- New York, N.Y. -- Science. 1979 Aug 24;205(4408):746.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/462186" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Carcinogens ; *Drug Evaluation, Preclinical ; *National Institutes of Health (U.S.) ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 30
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    Risk and responsibility (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-07-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bazelon, D L -- New York, N.Y. -- Science. 1979 Jul 20;205(4403):277-80.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451598" target="_blank"〉PubMed〈/a〉
    Keywords: Decision Making ; Government Agencies ; Jurisprudence ; *Legislation as Topic ; Legislation, Drug ; Power Plants ; *Probability ; Public Opinion ; *Risk ; *Science ; United States
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  • 31
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    Cancer and industrial chemical production (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Davis, D L -- Magee, B H -- New York, N.Y. -- Science. 1979 Dec 21;206(4425):1356, 1358.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/505010" target="_blank"〉PubMed〈/a〉
    Keywords: Environmental Exposure ; Humans ; *Industry ; Neoplasms/*chemically induced/epidemiology ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 32
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    Membrane effects of thyrotropin-releasing hormone and estrogen shown by intracellular recording from pituitary cells (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-05-04
    Description: The effects of thyrotropin-releasing hormone and 17 beta-estradiol on the electrical membrane properties of a prolactin-secretin pituitary cell line (GH3/B6) were studied with intracellular microelectrode recordings. Of the cells tested, 50 percent were excitable and displayed calcium-dependent action potentials when depolarized. When injected directly on the membrane of an excitable cell, thyrotropin-releasing hormone and 17 beta-estradiol induced action potentials within 1 minute. The spiking activity was preceded by a progressive increase of the input resistance without any detectable change in the resting membrane polarization. The results reveal a rapid effect of both substances on the membrane of GH3/B6 cells. In the case of thyrotropin-releasing hormone, which has both a short-term effect on release of prolactin and a long-term effect on its synthesis, the induced electrical activity may be associated with the stimulation of prolactin production. The physiological implication of 17 beta-estradiol-induced, calcium-dependent spiking activity remains to be elucidated.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dufy, B -- Vincent, J D -- Fleury, H -- Du Pasquier, P -- Gourdji, D -- Tixier-Vidal, A -- New York, N.Y. -- Science. 1979 May 4;204(4392):509-11.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/107590" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials/drug effects ; Cell Line ; Cell Membrane/drug effects ; Estradiol/*pharmacology ; Pituitary Gland/*drug effects ; Stimulation, Chemical ; Thyrotropin-Releasing Hormone/*pharmacology
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  • 33
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    Opiate (Enkephalin) receptors of neuroblastoma cells: occurrence in clusters on the cell surface (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-30
    Description: A bioactive, fluorescent derivative of enkephalin, Tyr-D-Ala-Gly-Phe-Leu-Lys-rhodamine, was used to determine the distribution of opiate receptors in living neuroblastoma cells. The receptors appeared in clusters on the cell surface, and no internalization was detected. No specific fluorescence or clusters were observed in the presence of [D-Ala2, Leu5]enkephalin or at 4 degrees C, and the clusters were much reduced under ionic conditions (that is, with 100 millimolars sodium) that specifically decrease the binding of opiate agonists.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hazum, E -- Chang, K J -- Cuatrecasas, P -- New York, N.Y. -- Science. 1979 Nov 30;206(4422):1077-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/227058" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Endorphins/*metabolism ; Enkephalins/*metabolism ; Mice ; Microscopy, Fluorescence ; Neoplasms, Experimental/metabolism ; Neuroblastoma/*metabolism ; Receptors, Opioid/*metabolism ; Synaptic Membranes/metabolism
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  • 34
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    Phenformin ban (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-04-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Finkel, M J -- New York, N.Y. -- Science. 1979 Apr 20;204(4390):242.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/432643" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; Phenformin/adverse effects/*standards ; United States ; United States Food and Drug Administration
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 35
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    Noncycling tumor cells are sensitive targets for the antiproliferative activity of human interferon (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-30
    Description: Resting Burkitt's lymphoma cells (Daudi) in culture are more sensitive targets for the antiproliferative activity of purified human fibroblast interferon than cells that are rapidly multiplying. Thus, interferon may be of significant clinical value in neoplasms involving stem cells and, after chemotherapy, in suppressing the reemergence of tumors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Horoszewicz, J S -- Leong, S S -- Carter, W A -- New York, N.Y. -- Science. 1979 Nov 30;206(4422):1091-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493995" target="_blank"〉PubMed〈/a〉
    Keywords: Burkitt Lymphoma/drug therapy/pathology ; Cell Cycle/drug effects ; Cell Division/*drug effects ; Cell Line ; Cells, Cultured ; Humans ; Interferons/*pharmacology/therapeutic use ; Lymphocytes/drug effects
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  • 36
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    Peer review comes to ADAMHA (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-05-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1979 May 11;204(4393):601-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/219482" target="_blank"〉PubMed〈/a〉
    Keywords: *Peer Review ; Research Support as Topic ; United States ; *United States Substance Abuse and Mental Health Services Administration
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 37
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    Nuclear transcripts of mouse heavy chain immunoglobulin genes contain only the expressed class of C-region sequences (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-06-08
    Description: In plasmacytoma cells producing IgG, IgA, or IgM immunoglobulin heavy chains, the large precursors of the heavy chain messenger RNA's contain nucleotide sequences that specify only the expressed class of constant region. This indicates that the switch from one class of heavy chain to another during B cell ontogeny does not occur by altered processing of a complex gene transcript.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marcu, K B -- Schibler, U -- Perry, R P -- New York, N.Y. -- Science. 1979 Jun 8;204(4397):1087-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/109919" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Cell Line ; Cell Nucleus/metabolism ; Immunoglobulin Constant Regions/*genetics ; Immunoglobulin Heavy Chains/*genetics ; Immunoglobulins/*genetics ; Mice ; Myeloma Proteins/*genetics ; Neoplasms, Experimental/immunology ; Nucleic Acid Precursors/genetics ; Plasmacytoma/immunology ; Poly A/metabolism ; RNA, Heterogeneous Nuclear/genetics ; *Transcription, Genetic
    Print ISSN: 0036-8075
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  • 38
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    Scientists quit antibiotics panel at CAST (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-02-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1979 Feb 23;203(4382):732-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/581708" target="_blank"〉PubMed〈/a〉
    Keywords: Animal Feed/*standards ; Anti-Bacterial Agents/*standards ; Economics ; Microbiology ; United States ; United States Food and Drug Administration
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 39
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    Lasker award stirs controversy (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-01-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J L -- New York, N.Y. -- Science. 1979 Jan 26;203(4378):341.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/216074" target="_blank"〉PubMed〈/a〉
    Keywords: *Awards and Prizes ; National Institutes of Health (U.S.) ; *Receptors, Opioid ; *Research ; United States
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  • 40
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    Chemotactic responses of tumor cells to products of resorbing bone (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-01-12
    Description: To explore possible mechanisms for the metastasis of malignant cells to bone, a model of tumor cell migration was developed, using Walker carcinosarcoma or malignant lymphoma cells. It was found that bone contains a factor that is strongly chemotactic for tumor cells. This factoor is released by a variety of agents that induce resorption of bone.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Orr, W -- Varani, J -- Gondex, M K -- Ward, P A -- Mundy, G R -- New York, N.Y. -- Science. 1979 Jan 12;203(4376):176-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/569363" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bone Resorption/*physiopathology ; Bone and Bones/*physiopathology ; Carcinoma 256, Walker/*physiopathology ; Cell Line ; Cell Movement ; *Chemotaxis ; Chemotaxis, Leukocyte ; Lymphoma/physiopathology ; Neoplasm Metastasis ; Neoplasms, Experimental/physiopathology ; Organ Culture Techniques
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  • 41
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    Air is once again rent by drug lag claims (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-07-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, R J -- New York, N.Y. -- Science. 1979 Jul 20;205(4403):283.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451599" target="_blank"〉PubMed〈/a〉
    Keywords: *Drug Evaluation ; Legislation, Drug ; Time Factors ; United States ; *United States Food and Drug Administration
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  • 42
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    Toxic substances: EPA and OSHA are reluctant regulators (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-01-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, R J -- New York, N.Y. -- Science. 1979 Jan 5;203(4375):28-32.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/758675" target="_blank"〉PubMed〈/a〉
    Keywords: Cadmium/standards/toxicity ; Carcinogens/standards ; *Environmental Health ; *Government Agencies ; Humans ; Occupational Medicine/*standards ; Pesticides/toxicity ; United States
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  • 43
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    Study finds sleeping pills overprescribed (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-04-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, R J -- New York, N.Y. -- Science. 1979 Apr 20;204(4390):287-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/219479" target="_blank"〉PubMed〈/a〉
    Keywords: Barbiturates/adverse effects/pharmacology ; Benzodiazepines/adverse effects/metabolism ; Humans ; Hypnotics and Sedatives/*adverse effects ; Metabolic Clearance Rate ; Sleep, REM/drug effects ; United States ; United States Food and Drug Administration
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  • 44
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    Carter attempt to limit doctor supply faces tough going in Congress (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-02-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, R J -- New York, N.Y. -- Science. 1979 Feb 16;203(4381):630-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/760209" target="_blank"〉PubMed〈/a〉
    Keywords: Cost Control ; Delivery of Health Care/*economics ; Education, Medical/*manpower ; Legislation as Topic ; Physicians/*supply & distribution ; Training Support/*economics ; United States ; United States Dept. of Health and Human Services
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  • 45
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    Federal government faces painful decision on Darvon (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-03-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, R J -- New York, N.Y. -- Science. 1979 Mar 2;203(4383):857-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/419410" target="_blank"〉PubMed〈/a〉
    Keywords: Dextropropoxyphene/*adverse effects/therapeutic use ; Humans ; *Legislation, Drug ; Substance-Related Disorders ; United States ; United States Dept. of Health and Human Services
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Federal research grants (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-07-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Staats, E B -- New York, N.Y. -- Science. 1979 Jul 6;205(4401):18-20.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451578" target="_blank"〉PubMed〈/a〉
    Keywords: Government Agencies ; *Research Support as Topic ; United States ; Universities
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Human macrophage migration inhibition factor: evidence for subunit structure (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-07-20
    Description: Macrophage migration inhibition factor (MIF) derived from human lymphoid cell lines was found to lose biologic activity on dialysis. Although activity was not recovered in the dialyzate, mixing experiments demonstrated that the components in the retentate and dialyzate could reassociate to restore activity. The fragment of larger molecular weight (less than 10,000) could inhibit the activity of intact MIF, whereas the smaller molecular weight fragment (5,000 to 10,000) could not. These findings suggest that human MIF is composed of at least two noncovalently linked subunits. In analogy to the situation for certain bacterial toxins, one of these may represent an attachment piece for a target cell membrane receptor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Possanza, G -- Cohen, M C -- Yoshida, T -- Cohen, S -- New York, N.Y. -- Science. 1979 Jul 20;205(4403):300-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/377487" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Line ; Dialysis ; Humans ; In Vitro Techniques ; Lymphocytes/physiology ; Macromolecular Substances ; *Macrophage Migration-Inhibitory Factors ; Molecular Weight
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Diabetes drugs: clinical trial (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-04-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Prout, T E -- Knatterud, G L -- Meinert, C G -- New York, N.Y. -- Science. 1979 Apr 27;204(4391):362-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/375390" target="_blank"〉PubMed〈/a〉
    Keywords: Clinical Trials as Topic ; Control Groups ; Diabetes Mellitus/*drug therapy ; Drug Evaluation/methods ; Drug Therapy ; Humans ; Hypoglycemic Agents/*toxicity ; Risk Assessment ; United States ; United States Food and Drug Administration
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Margaret Mead: an American phenomenon, 1901--1978 (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-01-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Revelle, R -- New York, N.Y. -- Science. 1979 Jan 5;203(4375):39-40.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/364654" target="_blank"〉PubMed〈/a〉
    Keywords: Anthropology, Cultural/*history ; History, 20th Century ; Societies, Scientific/history ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Induction of differentiation in human promyelocytic leukemia cells by tumor promoters (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-05-25
    Description: Phorbol diester tumor promoters and the promoter mezerein convert human promyelocytic leukemia cells in culture into adherent, nonproliferating cells with many of the characteristics of macrophages. Other types of promoters such as anthralin, phenobarbital, and saccharin do not have this effect. Various compounds that can inhibit some of the biological and biochemical effects of tumor promoters do not interfere with the induction of cell adherence and differentiation by the effective promoters.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rovera, G -- O'Brien, T G -- Diamond, L -- New York, N.Y. -- Science. 1979 May 25;204(4395):868-70.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/286421" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Adhesion/drug effects ; Cell Differentiation/*drug effects ; Cell Line ; Humans ; Leukemia, Myeloid, Acute/*pathology ; Phorbol Esters/pharmacology ; Phorbols/*pharmacology ; Tetradecanoylphorbol Acetate/*pharmacology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Spectacular science and ponderous process (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-01-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Singer, M F -- New York, N.Y. -- Science. 1979 Jan 5;203(4375):9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/758684" target="_blank"〉PubMed〈/a〉
    Keywords: *Advisory Committees ; DNA, Recombinant/*standards ; Federal Government ; *Government Regulation ; Research Design/standards ; Safety ; United States ; United States Dept. of Health and Human Services
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    EPA halts most use of herbicide 2,4,5-T (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-03-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, J -- New York, N.Y. -- Science. 1979 Mar 16;203(4385):1090-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/424734" target="_blank"〉PubMed〈/a〉
    Keywords: 2,4,5-Trichlorophenoxyacetic Acid/adverse effects/*standards ; Abortion, Spontaneous/*chemically induced ; Female ; Government Agencies ; Humans ; Legislation, Drug ; Pregnancy ; Tetrachlorodibenzodioxin/toxicity ; United States
    Print ISSN: 0036-8075
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  • 53
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    Cancer policy announced (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-10-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, R J -- New York, N.Y. -- Science. 1979 Oct 19;206(4416):313.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/482941" target="_blank"〉PubMed〈/a〉
    Keywords: *Carcinogens ; Government Agencies ; Risk ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Jere Goyan brings innovative record to FDA (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-10-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, R J -- New York, N.Y. -- Science. 1979 Oct 12;206(4415):200-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/482934" target="_blank"〉PubMed〈/a〉
    Keywords: Pharmacy/standards ; United States ; *United States Food and Drug Administration/organization & administration
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    U.S. beginning to act on banned pesticides (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-06-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, R J -- New York, N.Y. -- Science. 1979 Jun 29;204(4400):1391-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451572" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Developing Countries ; Humans ; Legislation as Topic ; *Pesticides/poisoning ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Henry Waxman still faces an uphill battle (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-03-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, R J -- New York, N.Y. -- Science. 1979 Mar 30;203(4387):1319, 1321-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/370981" target="_blank"〉PubMed〈/a〉
    Keywords: California ; History of Medicine ; *Legislation as Topic ; Politics ; United States
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    Institute of Medicine report recommends complete overhaul of food safety laws (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-03-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, R J -- New York, N.Y. -- Science. 1979 Mar 23;203(4386):1221-2, 1224.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/424748" target="_blank"〉PubMed〈/a〉
    Keywords: Carcinogens ; Dose-Response Relationship, Drug ; Food Additives/*standards ; Saccharin ; United States ; United States Food and Drug Administration
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Major relaxation in DNA rules (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wade, N -- New York, N.Y. -- Science. 1979 Sep 21;205(4412):1238.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472740" target="_blank"〉PubMed〈/a〉
    Keywords: *DNA, Recombinant ; National Institutes of Health (U.S.) ; Research Design/standards ; United States
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    GABA receptors in clonal cell lines: a model for study of benzodiazepine action at molecular level (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-24
    Description: A "recptor unit" for gamma-aminobutyric acid (GABA), which includes brainlike receptor binding sites for tritium-labeled GABA and benzodiazepines (diazepam, clonazepam, and flunitrazepam) and a thermostable endogenous protein (GABA modulin) that inhibits both GABA and benzodiazepine binding, has been demonstrated in membranes prepared from NB2a neuroblastoma and C6 glioma clonal cell lines. In these cells, as in brain, diazepam (1 micromolar) prevents the effect of GABA modulin, and in turn GABA (0.oma and, to a lesser extent, the glioma cells represent a suitable model to study the interactions and the sequence of membrane and intracellular events triggered by the stimulation of benzodiazepine and GABA receptors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Baraldi, M -- Guidotti, A -- Schwartz, J P -- Costa, E -- New York, N.Y. -- Science. 1979 Aug 24;205(4408):821-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/462192" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Benzodiazepines/*metabolism ; Brain/*metabolism ; Cell Line ; Clonazepam/metabolism ; Clone Cells/metabolism ; Diazepam/metabolism/pharmacology ; Flunitrazepam/metabolism ; Membrane Proteins/pharmacology ; Mice ; Nerve Tissue Proteins/pharmacology ; Rats ; Receptors, Drug/*metabolism ; gamma-Aminobutyric Acid/*metabolism
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    Proposals for ethics boards stir debate (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-07-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Broad, W J -- New York, N.Y. -- Science. 1979 Jul 20;205(4403):285-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451600" target="_blank"〉PubMed〈/a〉
    Keywords: Compensation and Redress ; *Ethics Committees, Research ; Ethics, Medical ; Federal Government ; Government Regulation ; *Human Experimentation ; Humans ; *Informed Consent ; *Professional Staff Committees/legislation & jurisprudence ; Risk ; United States
    Print ISSN: 0036-8075
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    Paul Feyerabend: science and the anarchist (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Broad, W J -- New York, N.Y. -- Science. 1979 Nov 2;206(4418):534-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/386510" target="_blank"〉PubMed〈/a〉
    Keywords: History, 20th Century ; Logic ; *Philosophy ; Science/history ; United States
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    Dollars for drug research flow overseas (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Broad, W J -- New York, N.Y. -- Science. 1979 Sep 7;205(4410):979-80.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472730" target="_blank"〉PubMed〈/a〉
    Keywords: Drug Evaluation/methods ; Drug Evaluation, Preclinical/methods ; *Drug Industry ; Economics ; Federal Government ; Government Regulation ; *Internationality ; United States ; United States Food and Drug Administration
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    How to assess cancer risks (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-05-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carter, L J -- New York, N.Y. -- Science. 1979 May 25;204(4395):811, 813, 815-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/441737" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Government Agencies ; Humans ; Mice ; Neoplasms/*chemically induced ; Rats ; Risk ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    A new and searching look at NSF (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-06-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carter, L J -- New York, N.Y. -- Science. 1979 Jun 8;204(4397):1064-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451550" target="_blank"〉PubMed〈/a〉
    Keywords: *Government Agencies ; Legislation as Topic ; Research Support as Topic ; *Science ; United States
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    Should there be a commission on medical education? (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-10
    Description: In its premedical and preclinical phases our present scheme of education for medicine is intellectually deficient, wasteful of money and time, and in urgent need of overhaul. The author defines conditions under which a national commission might possibly set the educational process on the road to reform.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chapman, C B -- New York, N.Y. -- Science. 1979 Aug 10;205(4406):559-62.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451620" target="_blank"〉PubMed〈/a〉
    Keywords: Education, Medical/*standards ; *Professional Staff Committees ; United States
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    FDA tells senators of doctors who fake data in clinical drug trials (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-10-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1979 Oct 26;206(4417):423-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/504984" target="_blank"〉PubMed〈/a〉
    Keywords: Clinical Trials as Topic/*standards ; Drug Industry/standards ; Legislation as Topic ; United States ; United States Food and Drug Administration
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 67
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    Human and mouse hypoxanthine-guanine phosphoribosyltransferase: dimers and tetramers (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-01-12
    Description: Human and mouse hypoxanthine-guanine phosphoribosyltransferase subunits combine to form an active heteropolymer. Dimers form the basic subunit structure of the enzymes, yet the dimers can readily associate to form tetramers. The equilibrium between dimers and tetramers is significantly influenced by the ionic strength of the enzyme solvent.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Johnson, G G -- Eisenberg, L R -- Migeon, B R -- New York, N.Y. -- Science. 1979 Jan 12;203(4376):174-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/569362" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Female ; Genetic Linkage ; Humans ; Hybrid Cells/enzymology ; *Hypoxanthine Phosphoribosyltransferase/genetics ; Macromolecular Substances ; Mice ; Molecular Weight ; Protein Conformation ; X Chromosome
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    Differential mortality by sex in fetal and neonatal deaths (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-04-06
    Description: Vital statistics data for the United States from 1922 to 1936 and from 1950 to 1972 were used to analyze fetal and early neonatal mortality. This analysis corroborates the previously established pattern of the sex ratio of fetal deaths--highest from months 3 to 5, lower from months 6 to 7 or 8, and increasing at term. It also indicates a postponement of late fetal deaths into the early infant period. Whereas earlier research reports have described the pattern of the sex ratio of fetal deaths, this report repeats this analysis for a recent national data base. This line of analysis is extended by using the patterns observed in the data to produce an empirical estimate of the primary sex ratio. For 1950 to 1972, this ratio (male to female) is conservatively estimated to be 120:100.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McMillen, M M -- New York, N.Y. -- Science. 1979 Apr 6;204(4388):89-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/571144" target="_blank"〉PubMed〈/a〉
    Keywords: Female ; Fetal Death/*epidemiology ; Humans ; *Infant Mortality ; Male ; Pregnancy ; *Sex Ratio ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    OSHA carcinogen policy delayed (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-01-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, J R -- New York, N.Y. -- Science. 1979 Jan 5;203(4375):35.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/758676" target="_blank"〉PubMed〈/a〉
    Keywords: Carcinogens/standards ; *Government Agencies ; Laboratories/standards ; Occupational Medicine/*standards ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 70
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    Court reluctantly upholds EPA on 2,4,5-T suspension (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-05-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, R J -- New York, N.Y. -- Science. 1979 May 11;204(4393):602.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/432664" target="_blank"〉PubMed〈/a〉
    Keywords: 2,4,5-Trichlorophenoxyacetic Acid/*standards ; *Government Agencies ; Jurisprudence ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 71
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    Joint statement issued by CDC, HEW, NIEHS (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-07-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, R J -- New York, N.Y. -- Science. 1979 Jul 20;205(4403):282.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/221981" target="_blank"〉PubMed〈/a〉
    Keywords: *Cannabis ; Centers for Disease Control and Prevention (U.S.) ; Humans ; National Institutes of Health (U.S.) ; Paraquat/*poisoning ; United States ; United States Dept. of Health and Human Services
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  • 72
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    Regulators defend their turf (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-11-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carter, L J -- New York, N.Y. -- Science. 1978 Nov 10;202(4368):603.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/705348" target="_blank"〉PubMed〈/a〉
    Keywords: Economics ; *Environmental Health ; Government Agencies ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 73
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    Uranium mill tailings: Congress addresses a long-neglected problem (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-10-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carter, L J -- New York, N.Y. -- Science. 1978 Oct 13;202(4364):191-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/694524" target="_blank"〉PubMed〈/a〉
    Keywords: *Environmental Exposure ; Legislation as Topic ; Mining/*standards ; New Mexico ; United States ; *Uranium ; Utah
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 74
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    Cellular interactions uncouple beta-adrenergic receptors from adenylate cyclase (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-11-17
    Description: C6 glioma cells and B104 neuroblastoma cells both possess adenylate cyclase activity, but only C6 cells have beta-adrenergic receptors. However, when cocultured with B104 cells, C6 cells show a marked decrease in their ability to accumulate adenosine 3', 5'-monophosphate upon stimulation with beta receptor agonists. Since both beta receptors and cholera toxin-stimulated adenylate cyclase activities are present in C6/B104 cocultures, we conclude that the beta receptor/adenylate cyclase transduction mechanism in cocultured C6 cells is uncoupled.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ciment, G -- de Vellis, J -- New York, N.Y. -- Science. 1978 Nov 17;202(4369):765-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/213832" target="_blank"〉PubMed〈/a〉
    Keywords: Adenylyl Cyclases/*metabolism ; *Cell Communication ; Cell Line ; Cholera Toxin/pharmacology ; Cyclic AMP/metabolism ; Enzyme Activation/drug effects ; Membrane Proteins/metabolism ; Protein Binding ; Receptors, Adrenergic/*metabolism ; Receptors, Adrenergic, beta/*metabolism
    Print ISSN: 0036-8075
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  • 75
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    Rabies viruses increase in virulence when propagated in neuroblastoma cell culture (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-03-10
    Description: Several strains of attenuated rabies virus lacking the capacity to kill adult mice acquired a high lethal potential for mice after one to five serial passages in murine or human neuroblastoma cells. The virulence acquired after passage in neuroblastoma cells is a stable genetic trait retained during subsequent passage of viruses in nonneuroblastoma cell systems.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Clark, H F -- New York, N.Y. -- Science. 1978 Mar 10;199(4333):1072-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/628831" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Cells, Cultured ; Mice ; Neuroblastoma/*microbiology ; Neurons/microbiology ; Rabies Vaccines/toxicity ; Rabies virus/genetics/*pathogenicity ; Vaccines, Attenuated/toxicity ; Virus Replication
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  • 76
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    Estrogen-binding sites in endothelial cell cultures (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-09-01
    Description: The cytosol extracted from a vascular endothelial cell line binds [3H]estradiol with high affinity and a high degree of specificity. In contrast, in experiments performed with cytosol labeled in the intact cell, progesterone and, to a smaller extent, testosterone gave an apparent inhibition of estradiol binding. These data support the concept that ovarian hormones may influence the role of the endothelium in various physiological and pathophysiological conditions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Colburn, P -- Buonassisi, V -- New York, N.Y. -- Science. 1978 Sep 1;201(4358):817-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/684408" target="_blank"〉PubMed〈/a〉
    Keywords: Aorta/*metabolism ; Cell Line ; Cytosol/metabolism ; Diethylstilbestrol/metabolism ; Endothelium/metabolism ; Estradiol/metabolism ; Progesterone/pharmacology ; Receptors, Estrogen/drug effects/*metabolism ; Testosterone/pharmacology
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  • 77
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    Changing postdoctoral career patterns for biomedical scientists (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-11-03
    Description: Between 1973 and 1977 the total number of Ph.D.'s holding postdoctoral appointments in the biomedical sciences increased at a rate of more than 550 individuals (12.5 percent) per year. During this same period the total number of doctorates awarded each year in these disciplines showed very little change. The postdoctoral growth can be attributed to substantial increases in both the numbers of recent graduates taking postdoctorals and the length of stay on these appointments. The lack of alternative employment opportunities has contributed heavily to the postdoctoral buildup. Continued growth is likely to have important consequences for biomedical research and research training.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Coggeshall, P E -- Norvell, J C -- Bogorad, L -- Bock, R M -- New York, N.Y. -- Science. 1978 Nov 3;202(4367):487-93.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/705338" target="_blank"〉PubMed〈/a〉
    Keywords: Biology/*manpower/trends ; Education, Continuing/*trends ; Employment ; *Research Support as Topic ; Salaries and Fringe Benefits ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 78
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    Health care economics: the high cost of getting well (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-05-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culliton, B J -- New York, N.Y. -- Science. 1978 May 26;200(4344):883-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/644330" target="_blank"〉PubMed〈/a〉
    Keywords: Bed Occupancy ; Diagnosis/economics ; Economics, Hospital ; *Economics, Medical ; Education, Medical ; Fees and Charges ; Insurance, Health/economics ; Legislation, Medical ; Medical Laboratory Science/economics ; Therapeutics/economics ; United States
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  • 79
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    The quality of medical care (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-05-26
    Description: This article classifies the major approaches to the assessment of the process and outcomes of medical care. The apparent need to safeguard and enhance the quality of care has led to the institution of mechanisms that subject care to constant review so that deficiencies may be found and corrected. The article reviews the developments that led to the involvement of the federal government in this activity through its sponsorship of professional standards review organizations (PSRO's). The major features of the PSRO's are described and their possible effects discussed. It is too early to say how the PSRO's will fare, but should they fail to accomplish their objectives the pressure for more radical solutions will be difficult to resist.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Donabedian, A -- New York, N.Y. -- Science. 1978 May 26;200(4344):856-64.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/417400" target="_blank"〉PubMed〈/a〉
    Keywords: Computers ; Concurrent Review ; Cost-Benefit Analysis ; Humans ; Medical Records/standards ; Methods ; Peer Review ; Physician-Patient Relations ; Professional Review Organizations/economics/legislation & jurisprudence/standards ; *Quality of Health Care ; United States
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  • 80
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    How valuable are scientific exchanges with the Soviet Union? (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-10-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Graham, L R -- New York, N.Y. -- Science. 1978 Oct 27;202(4366):383-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/705332" target="_blank"〉PubMed〈/a〉
    Keywords: *Foreign Professional Personnel ; *International Cooperation ; *Science ; Ussr ; United States
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  • 81
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    Research involving human subjects (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-09-22
    Description: This article reports a study of the activities and performance of institutional review boards to protect human research subjects. Researchers and institutional review board members were generally supportive of the review system, although substantial criticisms were also heard. Institutional review boards had some direct impact on half of the proposals reviewed by requiring either modification of or additional information about proposed research. The data, however, raise questions about the effectiveness of some review board actions, for example, with regard to informed consent. Some policy implications of the study are presented.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gray, B H -- Cooke, R A -- Tannenbaum, A S -- New York, N.Y. -- Science. 1978 Sep 22;201(4361):1094-101.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/356268" target="_blank"〉PubMed〈/a〉
    Keywords: Attitude ; Behavioral Research ; Bioethics ; Clinical Trials as Topic ; Consent Forms ; *Ethical Review ; *Ethics Committees, Research ; *Human Experimentation ; Humans ; Informed Consent ; *Research/standards ; Risk ; Risk Assessment ; United States ; United States Dept. of Health and Human Services
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  • 82
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    Trisodium phosphonoformate, a new antiviral compound (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-09-01
    Description: Trisodium phosphonoformate selectively inhibits cell-free DNA polymerase activity induced by herpesvirus. The new inhibitor has an antiviral effect on herpes simplex virus types 1 and 2, pseudorables virus, and infectious bovine rhinotracheitis virus in cell culture. It has a good therapeutic activity against cutaneous herpes simplex virus infection in guinea pigs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Helgstrand, E -- Eriksson, B -- Johansson, N G -- Lannero, B -- Larsson, A -- Misiorny, A -- Noren, J O -- Sjoberg, B -- Stenberg, K -- Stening, G -- Stridh, S -- Oberg, B -- New York, N.Y. -- Science. 1978 Sep 1;201(4358):819-21.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/210500" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Antiviral Agents/therapeutic use/toxicity ; Cell Line ; DNA-Directed RNA Polymerases/*antagonists & inhibitors ; Formates/pharmacology/toxicity ; Guinea Pigs ; Herpesviridae Infections/drug therapy ; *Nucleic Acid Synthesis Inhibitors ; Organophosphorus Compounds/*pharmacology/toxicity ; Phosphonoacetic Acid/pharmacology ; Simplexvirus/enzymology
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  • 83
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    Upton OK's Laetrile test on humans (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-10-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Broad, W J -- New York, N.Y. -- Science. 1978 Oct 13;202(4364):196.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/694525" target="_blank"〉PubMed〈/a〉
    Keywords: Amygdalin/*therapeutic use ; Federal Government ; Humans ; National Institutes of Health (U.S.) ; Neoplasms/*drug therapy ; Research Support as Topic ; United States
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  • 84
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    Biological activity of some oxygenated sterols (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-08-11
    Description: A group of oxygenated sterols has been identified as potent and specific inhibitors of sterol biosynthesis. The ability of these compounds to inhibit sterol synthesis in cultured cells and the ineffectiveness of cholesterol under the same conditions suggest that feedback regulation of sterol biosynthesis may be brought about by an oxygenated sterol rather than by cholesterol. The nature of the regulatory sterol may vary in different cells with their specific requirements for cholesterol as a structural component or as a precursor of other steroid products. The use of oxygenated sterols to block sterol synthesis in cultured cells provides new information regarding the role of sterol in cell membrane structure and function. For example, de novo sterol synthesis is required for DNA synthesis and cell division by some cultured cells. Studies with cultured cells, and with rats and mice in vivo, suggest that oxygenated sterols could be of value in the treatment of several important human diseases.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kandutsch, A A -- Chen, H W -- Heiniger, H J -- New York, N.Y. -- Science. 1978 Aug 11;201(4355):498-501.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/663671" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/metabolism ; Cell Division ; Cell Line ; Cholesterol/biosynthesis/*metabolism ; Feedback ; Humans ; Hydroxycholesterols/*metabolism ; Hydroxymethylglutaryl CoA Reductases/metabolism ; Intestines/metabolism ; Ketosteroids/*metabolism ; Liver/metabolism
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  • 85
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    Care of the aged: old problems in need of new solutions (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-05-26
    Description: Long-term care for the aged in the United States is overly dependent upon the nursing home. This hospital-like model for long-term care is particularly inappropriate since it imposes a medical solution on a variety of social problems. An adequate long-term care program requires a range of resources in the community as well as in institutions; sheltered housing options seem a desirable alternative to the nursing home. To ensure the quality of nursing home care, the present focus on setting standards for care activities should be abandoned in favor of a focus on care outcomes (physical, mental, and social). In an effort to change our present perverse incentives in the nursing home industry, the proposal is made that nursing homes be reimbursed according to the degree to which patient outcomes meet predicted outcomes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kane, R L -- Kane, R A -- New York, N.Y. -- Science. 1978 May 26;200(4344):913-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/417403" target="_blank"〉PubMed〈/a〉
    Keywords: Aged ; Financing, Government ; Health Facilities, Proprietary ; *Homes for the Aged/economics ; Humans ; Long-Term Care/*methods ; *Nursing Homes/economics/standards ; Socioeconomic Factors ; United States
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  • 86
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    Enhancement of oncogenesis in C3H/10T1/2 mouse embryo cell cultures by saccharin (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-09-22
    Description: Impure and pure samples of saccharin (2 milligrams per milliliter) did not produce oncogenic transformation of C3H/10T1/2, clone 8, mouse embryo fibroblasts. However, after treatment of the cells with a nontransforming initiating dose (0.1 microgram per milliliter) of 3-methylcholanthrene, continuous treatment with either sample of saccharin (100 micrograms per milliliter) led to significant transformation. It is concluded that in this system saccharin is a cocarginogen, probably functioning as a promoting agent that is 1000-fold less active than the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mondal, S -- Brankow, D W -- Heidelberger, C -- New York, N.Y. -- Science. 1978 Sep 22;201(4361):1141-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/684434" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Carcinogens ; Cell Line ; Cell Transformation, Neoplastic/*chemically induced ; Cocarcinogenesis ; Embryo, Mammalian ; Methylcholanthrene ; Mice ; Mice, Inbred C3H ; Saccharin/*pharmacology ; Tetradecanoylphorbol Acetate
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  • 87
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    Growth inhibition of transformed cells with succinylated concanavalin A (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-09-01
    Description: Succinylated concanavalin A reversibly inhibits the growth of SV40 transformed mouse 3T3 cells and thus causes an accumulation of the cells in the G1 phase of the cell cycle. In a soft substrate (methylcellulose) succinylated concanavalin A also restores in transformed cells the growth behavior typical of untransformed cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mannino, R J -- Ballmer, K -- Burger, M M -- New York, N.Y. -- Science. 1978 Sep 1;201(4358):824-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/210502" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Adhesion/drug effects ; Cell Cycle/*drug effects ; Cell Line ; Cell Transformation, Neoplastic/*drug effects ; Concanavalin A/*analogs & derivatives/pharmacology ; Simian virus 40 ; Succinates
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 88
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    Environmental groups lose friends in effort to control DNA research (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-12-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1978 Dec 22;202(4374):1265-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/725600" target="_blank"〉PubMed〈/a〉
    Keywords: DNA, Recombinant/*standards ; Environment ; Environmental Pollution/prevention & control ; Government Regulation ; Legislation as Topic ; Research Design/*standards ; Risk Assessment ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 89
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    EPA smog standard attacked by industry, science advisers (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-12-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1978 Dec 1;202(4371):949-50.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/715452" target="_blank"〉PubMed〈/a〉
    Keywords: *Air Pollutants/toxicity ; Dose-Response Relationship, Drug ; Environmental Exposure ; Government Agencies ; Humans ; Industry ; Ozone/toxicity ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 90
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    Health officials fired up over "tolerable" cigarettes (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-09-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J L -- New York, N.Y. -- Science. 1978 Sep 1;201(4358):795-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/684406" target="_blank"〉PubMed〈/a〉
    Keywords: National Institutes of Health (U.S.) ; Nicotine/toxicity ; Smoking/*complications ; Tars/toxicity ; United States ; United States Dept. of Health and Human Services
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 91
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    Generation of new mouse sarcoma viruses in cell culture (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-09-01
    Description: Endogenous nontumor-producing type C viruses from C3H mice were used to generate rapid, solid tumor-inducing variants in cell culture. The new mouse sarcoma viruses induce undifferentiated sarcomas with a short latency period upon inoculation into newborn NIH Swiss mice. Transforming viruses appear only transiently, at a time when the virus-infected cells show morphologic alterations; both before and after this time, transforming viruses cannot be detected. These results show that variants of endogenous type C virus which contain transforming genes (oncogenes) can arise during spread of the endogenous virus in fibroblast lines in vitro as well as in susceptible tissues in vivo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rapp, U R -- Todaro, C -- New York, N.Y. -- Science. 1978 Sep 1;201(4358):821-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/210501" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; *Cell Transformation, Neoplastic ; Cell Transformation, Viral ; *Genes, Viral ; Mice ; Retroviridae/genetics/*pathogenicity ; Sarcoma Viruses, Murine/genetics/pathogenicity ; Sarcoma, Experimental/*microbiology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 92
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    Federal health spending passes the $50-billion mark (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-05-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Walsh, J -- New York, N.Y. -- Science. 1978 May 26;200(4344):886-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/347578" target="_blank"〉PubMed〈/a〉
    Keywords: Education, Medical ; *Financing, Government ; Health Services/*economics ; Legislation, Medical ; Medicaid/economics ; Medicare/economics ; Professional Review Organizations/economics ; Research Support as Topic ; Training Support ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 93
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    New rulebook for gene splicers faces one more test (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-08-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wade, N -- New York, N.Y. -- Science. 1978 Aug 18;201(4356):600-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/353985" target="_blank"〉PubMed〈/a〉
    Keywords: DNA, Recombinant/*standards ; DNA, Viral/genetics ; Escherichia coli/genetics/pathogenicity ; *Federal Government ; *Government Regulation ; National Institutes of Health (U.S.) ; Research Design/standards ; Risk Assessment ; United States ; United States Dept. of Health and Human Services
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 94
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    Biological warfare fears may impede last goal of smallpox eradicators (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-07-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wade, N -- New York, N.Y. -- Science. 1978 Jul 28;201(4353):329-30.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/208151" target="_blank"〉PubMed〈/a〉
    Keywords: *Biological Warfare ; Centers for Disease Control and Prevention (U.S.) ; *Smallpox/prevention & control ; United States ; Variola virus ; Virus Cultivation ; *World Health Organization
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 95
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    Antibody diversity (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-10-06
    Description: Three important aspects of immunoglobulin gene organization and structure have emerged from studies of cloned immunoglobulin kappa chain genes. (i) Multiple variable genes are encoded separately in the genome of both immunoglobulin-producing and uncommitted (embryonic) cells, thereby establishing the evolutionary base for generating immunoglobulin diversity. (ii) These genes exist as many small, closely related families (subgroups) that share close sequence homology largely within their own subgroup. (iii) Comparison of two cloned variable gene segments derived from a single subgroup reveals a feature of their structure that distinguishes them from fixed genes (that is, globin genes) and provides, through extensive surrounding sequence homology, a large target for intergenic recombination. This last observation suggests that a simple recombination mechanism may account for their genetic instability in both germ line and somatic cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Seidman, J G -- Leder, A -- Nau, M -- Norman, B -- Leder, P -- New York, N.Y. -- Science. 1978 Oct 6;202(4363):11-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/99815" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Antibody Specificity ; Base Sequence ; Binding Sites, Antibody/*genetics ; Biological Evolution ; Cell Line ; Embryo, Mammalian/immunology ; *Genes ; Immunoglobulin Constant Regions/*genetics ; Immunoglobulin Light Chains/*genetics ; Immunoglobulin Variable Region/*genetics ; Immunoglobulin kappa-Chains/*genetics ; Immunoglobulins/*genetics ; Mice ; Neoplasms, Experimental/immunology ; Plasmacytoma/immunology ; Recombination, Genetic
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 96
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    Policy recommendations to VA leave NAS at odds with Congress (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-03-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Walsh, J -- New York, N.Y. -- Science. 1978 Mar 3;199(4332):952-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/341315" target="_blank"〉PubMed〈/a〉
    Keywords: *Academies and Institutes ; *Delivery of Health Care ; *Public Policy ; United States ; *United States Department of Veterans Affairs
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 97
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    The problem of defensive medicine (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-05-26
    Description: Defensive medicine--the use of diagnostic and end-treatment measures explicitly for the purposes of averting malpractice suits--is frequently cited as one of the least desirable effects of the current rise in medical litigation. Many physicians and policy-makers claim that defensive medicine is responsible not only for the increasing costs of health care but the exposing of patients to significant risks of harm from unnecessary procedures. Very little solid information is available about defensive medicine. The studies that have been conducted have been fraught with statistical difficulties and are by no means definitive. Even more important than the issue of defensive medicine is the more basic problem of our system of compensation for medical injuries.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tancredi, L R -- Barondess, J A -- New York, N.Y. -- Science. 1978 May 26;200(4344):879-82.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/644329" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Cesarean Section/utilization ; Child ; Costs and Cost Analysis ; Craniocerebral Trauma/radiography ; *Defensive Medicine/economics ; Female ; Fetal Monitoring/utilization ; Humans ; *Malpractice/economics ; Physician-Patient Relations ; Pregnancy ; Quality of Health Care ; Surveys and Questionnaires ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 98
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    Carbon monoxide automobile emissions measured from the interior of a traveling automobile (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-03-17
    Description: During a procedure to monitor carbon monoxide (CO) concentrations inside a traveling car, it was discovered that CO emissions from individual passing vehicles produced accurately measurable increases in the CO concentration. The CO produced by individual vehicles varied by three orders of magnitude; this finding demonstrates that a relatively small number of cars can be responsible for a high percentage of total vehicle CO Emissions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chaney, L W -- New York, N.Y. -- Science. 1978 Mar 17;199(4334):1203-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/75569" target="_blank"〉PubMed〈/a〉
    Keywords: Automobile Driving ; Automobiles/standards ; Carbon Monoxide/*analysis ; Environment ; Rural Population ; United States ; Urban Population ; Vehicle Emissions/*analysis
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 99
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    Doctors and their autonomy: past events and future prospects (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-05-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chapman, C B -- New York, N.Y. -- Science. 1978 May 26;200(4344):851-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/347577" target="_blank"〉PubMed〈/a〉
    Keywords: Economics, Medical ; Great Britain ; History, 16th Century ; History, 17th Century ; History, 19th Century ; History, 20th Century ; History, Medieval ; Legislation, Medical/history ; Licensure, Medical/history ; *Malpractice/history ; *Peer Review ; *Physicians ; Quality of Health Care ; Societies, Medical/history ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 100
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    Research in instrument sharing (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-08-04
    Description: Continued progress in many areas of science depends on access to advanced modern instruments and the data they provide. Costly instruments have been shared in a number of disciplines for many years, and common patterns of shared usage have developed independently. The scientific and financial aspects of large instrument usage are discussed from the points of view of the instrument centers, the users, and the funding agencies. The instrument problem is not one problem but many, and coordinated solutions must be implemented with well-defined goals based on knowledge of the needs of the users and developers of instruments.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Coulter, C L -- New York, N.Y. -- Science. 1978 Aug 4;201(4354):415-20.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/663665" target="_blank"〉PubMed〈/a〉
    Keywords: Biophysics/instrumentation ; Cell Biology/instrumentation ; Chemistry/instrumentation ; Computers/supply & distribution ; *Equipment and Supplies ; Government Agencies ; Microscopy, Electron/instrumentation ; Molecular Biology/instrumentation ; Particle Accelerators/supply & distribution ; *Research ; Research Support as Topic ; Spectrum Analysis/instrumentation ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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