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  • United States  (110)
  • Cell Line  (35)
  • Phosphorylation
  • American Association for the Advancement of Science (AAAS)  (151)
  • American Association of Petroleum Geologists (AAPG)
  • Bonn: Institute of Labor Economics (IZA)
  • Cornell University Press
  • 1975-1979  (151)
Collection
Keywords
Publisher
  • American Association for the Advancement of Science (AAAS)  (151)
  • American Association of Petroleum Geologists (AAPG)
  • Bonn: Institute of Labor Economics (IZA)
  • Cornell University Press
  • Springer  (6)
Years
Year
  • 101
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    Antibody diversity (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-10-06
    Description: Three important aspects of immunoglobulin gene organization and structure have emerged from studies of cloned immunoglobulin kappa chain genes. (i) Multiple variable genes are encoded separately in the genome of both immunoglobulin-producing and uncommitted (embryonic) cells, thereby establishing the evolutionary base for generating immunoglobulin diversity. (ii) These genes exist as many small, closely related families (subgroups) that share close sequence homology largely within their own subgroup. (iii) Comparison of two cloned variable gene segments derived from a single subgroup reveals a feature of their structure that distinguishes them from fixed genes (that is, globin genes) and provides, through extensive surrounding sequence homology, a large target for intergenic recombination. This last observation suggests that a simple recombination mechanism may account for their genetic instability in both germ line and somatic cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Seidman, J G -- Leder, A -- Nau, M -- Norman, B -- Leder, P -- New York, N.Y. -- Science. 1978 Oct 6;202(4363):11-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/99815" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Antibody Specificity ; Base Sequence ; Binding Sites, Antibody/*genetics ; Biological Evolution ; Cell Line ; Embryo, Mammalian/immunology ; *Genes ; Immunoglobulin Constant Regions/*genetics ; Immunoglobulin Light Chains/*genetics ; Immunoglobulin Variable Region/*genetics ; Immunoglobulin kappa-Chains/*genetics ; Immunoglobulins/*genetics ; Mice ; Neoplasms, Experimental/immunology ; Plasmacytoma/immunology ; Recombination, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 102
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    Policy recommendations to VA leave NAS at odds with Congress (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-03-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Walsh, J -- New York, N.Y. -- Science. 1978 Mar 3;199(4332):952-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/341315" target="_blank"〉PubMed〈/a〉
    Keywords: *Academies and Institutes ; *Delivery of Health Care ; *Public Policy ; United States ; *United States Department of Veterans Affairs
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 103
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    The problem of defensive medicine (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-05-26
    Description: Defensive medicine--the use of diagnostic and end-treatment measures explicitly for the purposes of averting malpractice suits--is frequently cited as one of the least desirable effects of the current rise in medical litigation. Many physicians and policy-makers claim that defensive medicine is responsible not only for the increasing costs of health care but the exposing of patients to significant risks of harm from unnecessary procedures. Very little solid information is available about defensive medicine. The studies that have been conducted have been fraught with statistical difficulties and are by no means definitive. Even more important than the issue of defensive medicine is the more basic problem of our system of compensation for medical injuries.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tancredi, L R -- Barondess, J A -- New York, N.Y. -- Science. 1978 May 26;200(4344):879-82.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/644329" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Cesarean Section/utilization ; Child ; Costs and Cost Analysis ; Craniocerebral Trauma/radiography ; *Defensive Medicine/economics ; Female ; Fetal Monitoring/utilization ; Humans ; *Malpractice/economics ; Physician-Patient Relations ; Pregnancy ; Quality of Health Care ; Surveys and Questionnaires ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 104
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    Carbon monoxide automobile emissions measured from the interior of a traveling automobile (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-03-17
    Description: During a procedure to monitor carbon monoxide (CO) concentrations inside a traveling car, it was discovered that CO emissions from individual passing vehicles produced accurately measurable increases in the CO concentration. The CO produced by individual vehicles varied by three orders of magnitude; this finding demonstrates that a relatively small number of cars can be responsible for a high percentage of total vehicle CO Emissions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chaney, L W -- New York, N.Y. -- Science. 1978 Mar 17;199(4334):1203-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/75569" target="_blank"〉PubMed〈/a〉
    Keywords: Automobile Driving ; Automobiles/standards ; Carbon Monoxide/*analysis ; Environment ; Rural Population ; United States ; Urban Population ; Vehicle Emissions/*analysis
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 105
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    Doctors and their autonomy: past events and future prospects (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-05-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chapman, C B -- New York, N.Y. -- Science. 1978 May 26;200(4344):851-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/347577" target="_blank"〉PubMed〈/a〉
    Keywords: Economics, Medical ; Great Britain ; History, 16th Century ; History, 17th Century ; History, 19th Century ; History, 20th Century ; History, Medieval ; Legislation, Medical/history ; Licensure, Medical/history ; *Malpractice/history ; *Peer Review ; *Physicians ; Quality of Health Care ; Societies, Medical/history ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 106
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    Research in instrument sharing (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-08-04
    Description: Continued progress in many areas of science depends on access to advanced modern instruments and the data they provide. Costly instruments have been shared in a number of disciplines for many years, and common patterns of shared usage have developed independently. The scientific and financial aspects of large instrument usage are discussed from the points of view of the instrument centers, the users, and the funding agencies. The instrument problem is not one problem but many, and coordinated solutions must be implemented with well-defined goals based on knowledge of the needs of the users and developers of instruments.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Coulter, C L -- New York, N.Y. -- Science. 1978 Aug 4;201(4354):415-20.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/663665" target="_blank"〉PubMed〈/a〉
    Keywords: Biophysics/instrumentation ; Cell Biology/instrumentation ; Chemistry/instrumentation ; Computers/supply & distribution ; *Equipment and Supplies ; Government Agencies ; Microscopy, Electron/instrumentation ; Molecular Biology/instrumentation ; Particle Accelerators/supply & distribution ; *Research ; Research Support as Topic ; Spectrum Analysis/instrumentation ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 107
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    Ethics advisory board confronts conception in the test tube (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-10-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culliton, B J -- New York, N.Y. -- Science. 1978 Oct 13;202(4364):198-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/567844" target="_blank"〉PubMed〈/a〉
    Keywords: Biomedical Research ; *Ethics, Medical ; Federal Government ; Female ; *Fertilization in Vitro ; Government Regulation ; Humans ; In Vitro Techniques ; Infertility/therapy ; Male ; National Institutes of Health (U.S.) ; Research Support as Topic ; Risk Assessment ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 108
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    Toxic substances legislation: how well are laws being implemented? (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-09-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culliton, B J -- New York, N.Y. -- Science. 1978 Sep 29;201(4362):1198-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/694509" target="_blank"〉PubMed〈/a〉
    Keywords: Carcinogens, Environmental ; *Environmental Pollutants ; Environmental Pollution/*prevention & control ; Government Agencies ; *Legislation as Topic ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 109
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    Information transfer: the biomedical model (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-12-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cummings, M M -- New York, N.Y. -- Science. 1978 Dec 22;202(4374):1247.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/364650" target="_blank"〉PubMed〈/a〉
    Keywords: *Information Systems ; *Medlars ; National Library of Medicine (U.S.) ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 110
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    Peter Bourne's mistake: a prescription for trouble (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-08-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culliton, B J -- New York, N.Y. -- Science. 1978 Aug 4;201(4354):421-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/351809" target="_blank"〉PubMed〈/a〉
    Keywords: Drug Prescriptions/*standards ; *Ethics, Pharmacy ; Government Agencies ; History, 20th Century ; Methaqualone/administration & dosage ; Psychiatry/history ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 111
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    Cancer death risk in hospitalized mental patients (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-09-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fox, B H -- New York, N.Y. -- Science. 1978 Sep 15;201(4360):966-968.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/684429" target="_blank"〉PubMed〈/a〉
    Keywords: Aged ; Female ; Hospitalization ; Humans ; Male ; Mental Disorders/*complications ; Middle Aged ; Neoplasms/*mortality ; Risk ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 112
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    Stimulated DNA synthesis in frog nuclei by cytoplasmic extracts of temperature-sensitive mammalian cells (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-08-18
    Description: Cytoplasmic extracts of proliferating cells stimulate DNA synthesis in isolated nuclei of Xenopus laevis liver. When tested by the same assay, cytoplasmic extracts of resting cells are completely inactive. When cytoplasmic extracts are prepared from cell cycle-specific temperature-sensitive mutants arrestd in the G1 phase of the cell cycle by the nonpermissive temperature, they also fail to stimulate DNA synthesis in frog nuclei. The results indicate that, to stimulate DNA synthesis in isolated frog nuclei, essentially all information of G1 cells must be present.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Floros, J -- Chang, H -- Baserga, R -- New York, N.Y. -- Science. 1978 Aug 18;201(4356):651-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/675253" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Cell Cycle ; Cell Line ; Cell Nucleus/*metabolism ; Chickens ; Cytoplasm/physiology ; DNA/*biosynthesis ; Liver/ultrastructure ; Mutation ; Temperature ; Xenopus
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 113
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    Evaluation of medical practices (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-05-26
    Description: Evaluation of the efficacy of a medical intervention requires valid measurements of both its benefits and risks as compared to those of alternative forms of management. The requisite measurements are more difficult to make than this simple description suggests, and the accumulation of information is further inhibited by certain characteristics of our pattern of health care. These features include, for example, discontinuous care by a variety of unrelated providers, inadequate records, the autonomy of physicians as decision-makers, financial disincentives, ambiguities in what we mean by "experimental" and "accepted" forms of therapy, and failure to see continuing evaluation as a necessary component of the cost of providing good medical care. Although no single change will solve all the problems of evaluation, several offer promise of improving our ability to choose from among medical interventions those most likely to be useful.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Frazier, H S -- Hiatt, H H -- New York, N.Y. -- Science. 1978 May 26;200(4344):875-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/417402" target="_blank"〉PubMed〈/a〉
    Keywords: Cost-Benefit Analysis ; Defensive Medicine ; Delivery of Health Care/organization & administration ; Diagnostic Errors ; Ethics, Medical ; Humans ; Malpractice ; Medical Records ; *Quality of Health Care/economics ; Quality of Life ; Risk ; Therapeutics ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 114
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    Macroeconomics of disease prevention in the United States (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-06-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gori, G B -- Richter, B J -- New York, N.Y. -- Science. 1978 Jun 9;200(4346):1124-30.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/653358" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Age Factors ; Aged ; Child ; Child, Preschool ; Costs and Cost Analysis ; Environment ; Female ; Government ; Humans ; Infant ; Life Expectancy ; Male ; Middle Aged ; Population Dynamics ; *Preventive Medicine ; Social Security ; Socioeconomic Factors ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 115
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    Regulating exposure to carcinogens (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-10-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Abelson, P H -- New York, N.Y. -- Science. 1978 Oct 13;202(4364):139.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/694522" target="_blank"〉PubMed〈/a〉
    Keywords: *Carcinogens ; Environmental Exposure ; Government Agencies ; Laboratories/standards ; Occupational Medicine/standards ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 116
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    The science base and social context of health maintenance: an overview (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-05-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hamburg, D A -- Brown, S S -- New York, N.Y. -- Science. 1978 May 26;200(4344):847-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/644327" target="_blank"〉PubMed〈/a〉
    Keywords: Accidents ; Biomedical Engineering ; Computers ; *Health Services/economics ; Insurance, Health ; Preventive Medicine ; Research ; Sociology ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 117
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    National health insurance: comments on selected issues (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-05-26
    Description: The primary objective of national health insurance is to make sure that good medical care is available to everyone at a price he or she can afford. Any plan when first adopted will have a role for both private and government insurance but, regardless of the mix, the combined system should meet the following goals: (i) to the extent possible the needs of low-income people should be met through plans that cover others; (ii) the part of the plan to be operated by government should be built on the administrative structure of Medicare, but with changes in reimbursement to encourage more efficient delivery of care; (iii) direct capital and manpower controls should be included; and (iv) rather than acting primarily as an insurer protecting people against the cost of medical care, the plan should be an aggressive buyer of health services, defining the product it is willing to buy and the price it is willing to pay.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ball, R M -- New York, N.Y. -- Science. 1978 May 26;200(4344):864-70.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/417401" target="_blank"〉PubMed〈/a〉
    Keywords: Costs and Cost Analysis ; Fees and Charges ; Health Expenditures ; *Health Services Accessibility ; Insurance, Health/economics ; Insurance, Health, Reimbursement ; Medical Indigency ; Medicare/organization & administration ; *National Health Insurance, United States/economics/organization & administration ; Preventive Medicine ; Professional Review Organizations ; Quality of Health Care ; Socioeconomic Factors ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 118
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    Senators hear case for psychotherapy (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-09-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1978 Sep 1;201(4358):794-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/356263" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; Insurance Benefits/legislation & jurisprudence ; Medicaid/*legislation & jurisprudence ; Medicare/*legislation & jurisprudence ; *Psychotherapy ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 119
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    New laetrile study leaves Cancer Institute in the pits (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-10-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Broad, W J -- New York, N.Y. -- Science. 1978 Oct 6;202(4363):33-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/694516" target="_blank"〉PubMed〈/a〉
    Keywords: Advisory Committees ; Amygdalin/*therapeutic use ; National Institutes of Health (U.S.) ; Neoplasms/*drug therapy ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 120
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    Need for reform in health professions accrediting (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-08-18
    Description: At least 50 vocational or professional groups, exclusive of specialties within categories, now provide a health service. Many have established accrediting procedures for maintaining educational standards, and the number is increasing. So great is the demand from the accrediting bodies that universities and academic health centers find that the cost in terms of money, time, and duplication of effort has become exhorbitant, and thereby a major problem in the management of educational institutions. The duplication of effort leads to fragmentation of the entire accrediting process, and this, in turn, fosters inadequate sharing of health professions educational experiences. A model is presented that would lessen the burden of accrediting on educational institutions and simultaneously permit testing of the feasibility of a multiprofessional accrediting mechanism.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brodie, D C -- Heaney, R P -- New York, N.Y. -- Science. 1978 Aug 18;201(4356):589-93.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/675243" target="_blank"〉PubMed〈/a〉
    Keywords: *Accreditation ; Health Occupations/education/*standards ; Research ; Societies ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Immunization against infectious disease (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-05-26
    Description: Mortality and morbidity from infectious diseases in the United States have declined more than 90 percent since 1900. Factors believed to be responsible for this decline include changes in the natural history of disease, sanitation, quarantine measures, control of nonhuman vectors, antibacterial drugs, and immunization. The contributions of each of these factors differ among the various infectious diseases; except for smallpox and diphtheria control, immunization had little effect until after World War II. The success of present and future immunization programs is endangered by public and physician complacency and by complex legal and ethical problems related to informed consent and responsibility for rare, vaccine-related injury.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mortimer, E A Jr -- New York, N.Y. -- Science. 1978 May 26;200(4344):902-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/347579" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Aged ; Child ; Child, Preschool ; *Communicable Disease Control ; Communicable Diseases/history/mortality ; History, 20th Century ; Humans ; *Immunization/adverse effects/history ; Infant ; Middle Aged ; United States ; Vaccination/history ; Vaccines/adverse effects ; Vaccines, Attenuated/adverse effects
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    Magnetic microspheres prepared by redox polymerization used in a cell separation based on gangliosides (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-06-02
    Description: A facile method is described for making magnetic microspheres that bind specifically to cell surfaces, in order to separate cells magnetophoretically. Control over the sizes of the spheres is effected by using their magnetic cores as part of a redox polymerization system. The use of the microspheres is demonstrated with a separation involving C-1300 neuroblastoma cells, 10% of which express the ganglioside GM1 in their membranes. The GM1-containing cells were separated with better than 99% purity, while the deficient cells were obtained at least 98% pure. The separation, which was carried out under sterile conditions, required only 6 minutes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kronick, P L -- Campbell, G L -- Joseph, K -- New York, N.Y. -- Science. 1978 Jun 2;200(4345):1074-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/653356" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Line ; Cell Separation/*methods ; *Gangliosides ; Magnetics ; Microspheres ; Neoplasms, Experimental/pathology ; Neuroblastoma/pathology ; Oxidation-Reduction
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    Science and technology: the road ahead (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-05-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Press, F -- New York, N.Y. -- Science. 1978 May 19;200(4343):737-41.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/644319" target="_blank"〉PubMed〈/a〉
    Keywords: Agriculture ; Climate ; Economics ; Environment ; Forecasting ; Government ; Research ; *Science ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Industry council challenges HEW on cancer in the workplace (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-11-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maugh, T H 2nd -- New York, N.Y. -- Science. 1978 Nov 10;202(4368):602-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/705347" target="_blank"〉PubMed〈/a〉
    Keywords: Environmental Exposure ; Neoplasms/*chemically induced ; Occupational Diseases/chemically induced/prevention & control ; Occupational Medicine/*standards ; Risk ; United States ; *United States Dept. of Health and Human Services
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Chemical carcinogens: the scientific basis for regulation (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-09-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maugh, T H 2nd -- New York, N.Y. -- Science. 1978 Sep 29;201(4362):1200-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/694510" target="_blank"〉PubMed〈/a〉
    Keywords: Biological Assay ; Biotransformation ; *Carcinogens, Environmental/metabolism/*pharmacology ; Cell Transformation, Neoplastic/drug effects ; Chromatids/drug effects ; Crossing Over, Genetic/drug effects ; Disease Models, Animal ; Environmental Exposure ; Government Agencies ; Mutation/drug effects ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 126
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    A fertility reaction to a historical event: southern white birthrates and the 1954 desegregation ruling (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-07-14
    Description: On 17 May 1954 the Supreme Court, in its decision in Brown v. Board of Education, declared de jure segregation of the public schools to be unconstitutional. It is argued here that a consequence of that decision was a decline in childbearing among white Southerners. In the nation as a whole, period fertility rates increased between 1954 and 1955, but in 9 of the 11 former Confederate states they decreased. Further analysis shows that these Southern fertility decreases began about 12 months after the Supreme Court decision. This variation in behavior in reaction to a historical event has important implications for the explanation and prediction of fertility.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rindfuss, R R -- Reed, J S -- John, C -- New York, N.Y. -- Science. 1978 Jul 14;201(4351):178-80.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/351806" target="_blank"〉PubMed〈/a〉
    Keywords: *Birth Rate ; *European Continental Ancestry Group ; History, 20th Century ; Human Rights ; Humans ; Legislation as Topic ; Psychology, Social ; *Schools ; *Social Change ; United States
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    Histamine H1 receptor-mediated guanosine 3',5'-monophosphate formation by cultured mouse neuroblastoma cells (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-07-07
    Description: Incubation of cultured mouse neuroblastoma cells with histamine caused a rapid and marked increase in the formation of guanosine 3',5'-monophosphate (cyclic GMP) by these cells. Receptor agonists for H1, but not H2, caused this effect which was reduced by H1 but not by H2 or muscarinic acetylcholine receptor antagonists. These results indicate that activation of H1 receptors in these cultured nerve cells stimulated cyclic GMP formation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Richelson, E -- New York, N.Y. -- Science. 1978 Jul 7;201(4350):69-71.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26974" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Calcium/pharmacology ; Carbachol/pharmacology ; Cell Line ; Cyclic GMP/*metabolism ; Histamine/*pharmacology ; Histamine H1 Antagonists/pharmacology ; Mice ; Neuroblastoma ; Neurons/*drug effects/metabolism ; Receptors, Histamine/*drug effects ; Receptors, Histamine H1/*drug effects
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    Myosin: immunofluorescent localization in neuronal and glial cultures (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-03-31
    Description: The distribution of intracellular myosin was studied by the double antibody immunofluorescence method in primary organotypic neuronal cultures and two established neuronal and glial cell lines. An array of parallel filaments aligned with the major cellular axis and a three-dimensional subsurface network were shown to react with two different myosin antibodies. The presence of myosin-rich filaments in regions known to contain actin filaments suggests that these proteins interact to generate the motive force in nonmuscle contractile systems.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Roisen, F -- Inczedy-Marcsek, M -- Hsu, L -- Yorke, W -- New York, N.Y. -- Science. 1978 Mar 31;199(4336):1445-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/343252" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Line ; Cytoplasm/ultrastructure ; Fluorescent Antibody Technique ; Ganglia, Spinal/cytology ; Myosins/*metabolism ; Neuroglia/*metabolism/ultrastructure ; Neurons/*metabolism/ultrastructure
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    Highly reiterated sequences of SIMIANSIMIANSIMIANSIMIANSIMIAN (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-04-28
    Description: A 172-base pair segment of DNA that is repeated several million times in the genome of the African green monkey has been characterized. Sequence analysis revealed that the many repeats of this complex unit are not all identical but represent a set of closely related segments: Sequence divergence occurs at various positions in the segment in a nonrandom manner. The uncloned segment obtained from monkey DNA is compared with a cloned segment of the same DNA which was recombined into the genome of simian virus 40 during permissive infection.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rosenberg, H -- Singer, M -- Rosenberg, M -- New York, N.Y. -- Science. 1978 Apr 28;200(4340):394-402.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/205944" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Biological Evolution ; Cell Line ; Cercopithecus/*genetics ; Cercopithecus aethiops/*genetics ; DNA/*genetics ; DNA Restriction Enzymes ; DNA, Recombinant ; Haplorhini ; Molecular Weight ; Recombination, Genetic ; Simian virus 40/genetics
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    The current emphasis on preventive medicine (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-05-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Saward, E -- Sorensen, A -- New York, N.Y. -- Science. 1978 May 26;200(4344):889-94.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/644331" target="_blank"〉PubMed〈/a〉
    Keywords: Attitude to Health ; Education, Medical ; Environment ; Environmental Exposure ; Environmental Health ; Government ; Humans ; Insurance, Health ; Nutritional Physiological Phenomena ; *Preventive Medicine ; Public Health ; Risk ; United States
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    Human breast cancer: androgen action mediated by estrogen receptor (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-02-17
    Description: Growth of the human breast cancer cell line MCF-7 is enhanced by androgens, but only at pharmacological concentrations. Although physiological concentrations of androgens translocate the androgen receptor into the nucleus, no mitogenic effects are observed. By contrast, pharmacological androgens translocate not only the androgen receptor but also the estrogen receptor, and at these high doses significantly increase both DNA and estrogen-dependent protein synthesis. We therefore propose that androgens stimulate MCF-7 cell growth not through the androgen receptor but rather through the estrogen receptor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zava, D T -- McGuire, W L -- New York, N.Y. -- Science. 1978 Feb 17;199(4330):787-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/622569" target="_blank"〉PubMed〈/a〉
    Keywords: Androgens/*pharmacology ; Breast Neoplasms/*metabolism ; Cell Line ; Cell Nucleus/drug effects/metabolism ; Cytoplasm/drug effects/metabolism ; Dihydrotestosterone/pharmacology ; Humans ; Receptors, Androgen/drug effects ; Receptors, Estrogen/drug effects/*physiology ; Receptors, Glucocorticoid/drug effects/metabolism ; Receptors, Progesterone/drug effects/metabolism ; Stimulation, Chemical ; Translocation, Genetic
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    United States population dose estimates for iodine-131 in the thyroid after the Chinese atmospheric nuclear weapons tests (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-04-07
    Description: Analysis of samples collected within the United States after the Chinese atmospheric nuclear weapons tests of 26 September and 17 November 1976 indicates that the radiation dose to the thyroid from iodine-131 in milk was predominant. A U.S. population dose to the thyroid of 68,000 man-rads was calculated for the iodine-131 fallout. The four excess thyroid cancers that are estimated to occur as a result of the September test during the next 45 years will be masked by the 380,000 cases of thyroid cancer which are expected to occur in the United States from all causes during the same interval.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, J M -- Broadway, J A -- Strong, A B -- New York, N.Y. -- Science. 1978 Apr 7;200(4337):44-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/565079" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Age Factors ; Air Pollution, Radioactive/analysis ; Animals ; Cattle ; Child ; Humans ; Infant ; Iodine Radioisotopes/*analysis ; Milk/analysis ; Neoplasms, Radiation-Induced/*etiology ; Radiation Monitoring ; Radioactive Fallout/*analysis ; Thyroid Neoplasms/epidemiology/*etiology ; United States
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    NAS saccharin report sweetens FDA position, but not by much (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-11-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, R J -- New York, N.Y. -- Science. 1978 Nov 24;202(4370):852-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/715446" target="_blank"〉PubMed〈/a〉
    Keywords: Age Factors ; *Carcinogens ; Cocarcinogenesis ; Female ; Humans ; Male ; Risk ; Saccharin/*adverse effects ; United States ; United States Food and Drug Administration
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    Foreign aid support of science and economic growth (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-03-17
    Description: The history of U.S. foreign aid support of science and technology in Latin America is examined and an attempt is made to evaluate the scientific and economic growth of that area in relation to the total foreign aid effort.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Szmant, H H -- New York, N.Y. -- Science. 1978 Mar 17;199(4334):1173-82.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/415363" target="_blank"〉PubMed〈/a〉
    Keywords: Chemistry ; Cost-Benefit Analysis ; Education ; History, 20th Century ; International Educational Exchange ; Latin America ; *Research Support as Topic ; *Science/history ; United States
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    Tumor promoters inhibit morphological differentiation in cultured mouse neuroblastoma cells (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-05-05
    Description: When added to mouse neuroblastoma cultures, the potent tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA) inhibits spontaneous neurite formation as well as that induced in response to serum deprivation, prostaglandin E1, 5-bromo-2'-deoxyuridine, and papaverine. Other tumor-promoting macrocyclic plant diterpenes also inhibit neurite formation, whereas nonpromoting diterpenes do not. Inhibition by TPA was reversible and was unrelated to toxicity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ishii, D N -- Fibach, E -- Yamasaki, H -- Weinstein, I B -- New York, N.Y. -- Science. 1978 May 5;200(4341):556-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/644318" target="_blank"〉PubMed〈/a〉
    Keywords: Bromodeoxyuridine/antagonists & inhibitors ; Cell Differentiation/drug effects ; Cell Line ; Diterpenes/pharmacology ; Dose-Response Relationship, Drug ; Neuroblastoma/pathology ; Neurons/*cytology ; Papaverine/antagonists & inhibitors ; Phorbols/*pharmacology ; Prostaglandins E/antagonists & inhibitors ; Tetradecanoylphorbol Acetate/*pharmacology
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    International cancer congress: AAAS clearinghouse (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-09-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kiernan, B A -- New York, N.Y. -- Science. 1978 Sep 15;201(4360):968.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/684430" target="_blank"〉PubMed〈/a〉
    Keywords: Argentina ; *Congresses as Topic ; Human Rights ; Humans ; *Information Services ; International Cooperation ; *Neoplasms ; *Societies, Scientific ; United States
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    The development and regulation of new medications (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-05-26
    Description: The unmet needs of many patients make the successful search for new and better drugs an urgent goal. Increasing regulatory demands have generated delays in the availability of new drugs and concerns about the long-term profitability of the innovative pharmaceutical industry. A rational and flexible approach to drug regulation could ease some of the most worrisome constraints without jeopardizing the public welfare. Changes in our national drug regulatory policy and in the performance of the Food and Drug Administration will serve our society better than drastic legislative mandates intended either to emasculate the FDA or to grant the agency broad new powers.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lasagna, L -- New York, N.Y. -- Science. 1978 May 26;200(4344):871-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/644328" target="_blank"〉PubMed〈/a〉
    Keywords: Drug Evaluation/standards ; Drug Industry ; Drug Stability ; Economics ; Nonprescription Drugs/standards ; *Pharmaceutical Preparations/standards ; Research ; United States ; *United States Food and Drug Administration
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    Nuclear waste: increasing scale and sociopolitical impacts (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-07-07
    Description: The article argues that insufficient attention has been paid to the operational aspects of the U.S. radioactive waste management system when it grows to the scale necessary to handle wastes produced by a fully deployed plutonium economy. Without such information, many of the unsettling speculations which have become part of the public debate and are summarized herein cannot be clearly addressed. The article then outlines the types of information necessary to begin estimating the costs and consequences of radioactive waste management. Finally, an index of social exposure to radioactive hazard is proposed to improve the basis for policy decisions in this area.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉LaPorte, T R -- New York, N.Y. -- Science. 1978 Jul 7;201(4350):22-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/663637" target="_blank"〉PubMed〈/a〉
    Keywords: Economics ; Forecasting ; Maximum Allowable Concentration ; Nuclear Reactors ; Politics ; Power Plants ; *Radioactive Waste ; Refuse Disposal/methods ; Sociology ; United States
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    Chick embryonic skin as a rapid organ culture assay for cellular neoplasia (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-03-03
    Description: We used chick embryonic skin (CES) in organ culture to assess the neoplastic potential of a variety of cultured human and nonhuman cell lines. Cells derived from cancer tissues grew in CES and formed tumors in nude mice while cells derived from normal tissues grew in neither system. The CES proved to be more sensitive than the nude mouse when used to assay SV40 transformed human cells; each of four such lines grew in CES while only one of the four lines grew and formed tumors in nude mice. In addition, the patterns of invasion by inoculated cells can be easily studied in the CES. These results suggest that CES in organ culture offers an inexpensive, rapid, and reliable alternative to the nude mouse as a tumorigenicity test.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Noguchi, P D -- Johnson, J B -- O'Donnell, R -- Petricciani, J C -- New York, N.Y. -- Science. 1978 Mar 3;199(4332):980-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/203036" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Division ; Cell Line ; Cell Survival ; *Cell Transformation, Neoplastic ; *Chick Embryo/metabolism ; Mice ; Mice, Nude ; Mitosis ; Neoplasm Invasiveness ; Neoplasms/*metabolism/pathology ; *Organ Culture Techniques ; Simian virus 40 ; Skin/*embryology/metabolism/pathology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 140
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    Histidine transfer RNA levels in Friend leukemia cells: stimulation by histidine deprivation (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-08-11
    Description: Friend leukemia cells incubated with sublethal concentrations of histidinol for 5 to 6 days show up to twofold increases in their relative concentrations of histidine transfer RNA and no change in the relative concentrations of leucine transfer RNA. A similar effect is seen when cells are grown to stationary phase in the presence of 0.2 times the amount of histidine in Eagle's minimum essential medium. These observations support the theory that the concentrations of specific transfer RNA's are regulated by a mechanism that is sensitive to the extent of their aminoacylation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Litt, M -- Weiser, K -- New York, N.Y. -- Science. 1978 Aug 11;201(4355):527-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/248241" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Division ; Cell Line ; Histidine/metabolism ; Histidine-tRNA Ligase/antagonists & inhibitors ; Histidinol/pharmacology ; Leucine/metabolism ; RNA, Transfer/*metabolism ; RNA, Transfer, Amino Acyl/*metabolism
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 141
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    Gene-splicing rules: another round of debate (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-01-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wade, N -- New York, N.Y. -- Science. 1978 Jan 6;199(4324):30-1, 33.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17569483" target="_blank"〉PubMed〈/a〉
    Keywords: Advisory Committees ; Containment of Biohazards ; *DNA, Recombinant ; Genetic Research/*legislation & jurisprudence ; *Government Regulation ; *Guidelines as Topic ; National Institutes of Health (U.S.)/*legislation & jurisprudence ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 142
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    Laboratory chemicals may come under costly OSHA restrictions (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-11-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, R J -- New York, N.Y. -- Science. 1978 Nov 3;202(4367):496-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/705339" target="_blank"〉PubMed〈/a〉
    Keywords: Carcinogens/analysis ; Environmental Exposure ; Government Agencies ; Laboratories/*standards ; Occupational Medicine/*standards ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 143
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    Regulation of macrophage tumoricidal function: a role for prostaglandins of the E series (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-10-20
    Description: Exogenously added prostaglandins E1 and E2, but not F2alpha, inhibited the tumoricidal activity of interferon-activated macrophages of mice. A role for adenosine 3',5'-monophosphate (cyclic AMP) in modulating macrophage functional activity was suggested because prostaglandins of the E series increase intracellular concentrations of cyclic AMP in macrophages and because treatment of interferon-activated macrophages with dibutyryl cyclic AMP consistently inhibits expression of cytotoxicity. Since the activated macrophage releases high concentrations of prostaglandin E2, it is postulated that this prostaglandin could act locally in negative feedback inhibition to limit cell activities.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schultz, R M -- Pavlidis, N A -- Stylos, W A -- Chirigos, M A -- New York, N.Y. -- Science. 1978 Oct 20;202(4365):320-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/694537" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Cytotoxicity, Immunologic/drug effects ; Immunity, Cellular/*drug effects ; Interferons/*antagonists & inhibitors ; Macrophages/*immunology ; Male ; Mice ; Neoplasms, Experimental/*immunology ; Nucleotides, Cyclic/pharmacology ; Prostaglandins E/*pharmacology ; Prostaglandins F/pharmacology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 144
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    EPA and toxic substances law: dealing with uncertainty (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-11-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Walsh, J -- New York, N.Y. -- Science. 1978 Nov 10;202(4368):602-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/705346" target="_blank"〉PubMed〈/a〉
    Keywords: Environmental Health ; *Government Agencies ; Industry ; Legislation as Topic ; *Occupational Medicine ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 145
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    L-Dopa methyl ester: prolongation of survival of neuroblastoma-bearing mice after treatment (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-02-17
    Description: L-Dopa has has been shown to demonstrate enhanced toxicity toward melanoma cells in vitro. Since melanocytes arise from the neural crest embryologically, the effect of L-dopa methyl ester, a soluble analog, on the murine C1300 neuroblastoma was studied. There was significant antitumor activity against the neuroblastoma, which was enhanced by combination with a dopa decarboxylase inhibitor, Ro4-4602. In vitro studies suggested inhibition of DNA synthesis as the principal site of action. A mechanism involving sulfhydryl compound scavenging is postulated.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wick, M M -- New York, N.Y. -- Science. 1978 Feb 17;199(4330):775-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/622565" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Benserazide/pharmacology ; Cell Line ; Drug Synergism ; Leucine/metabolism ; Levodopa/*analogs & derivatives/pharmacology/therapeutic use ; Male ; Mice ; Neoplasms, Experimental/drug therapy/metabolism ; Neuroblastoma/*drug therapy/metabolism ; Thymidine/metabolism ; Uridine/metabolism
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 146
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    Saccharin-induced sister chromatid exchanges in Chinese hamster and human cells (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-05-05
    Description: Since the induction of sister chromatid exchanges in cultured cells has been shown to be the most sensitive mammalian system to detect the effects of mutagenic carcinogens, Chinese hamster ovary cells and human lymphocytes were exposed to the sodium saccharin found to induce bladder cancer in rats. Both that saccharin and a highly purified extract of it increased the yield of sister chromatid exchanges in both types of cells. The results, which were repeatable and statistically highly significant, indicated that the weak carcinogen, saccharin, is also mutagenic in the sense that it induces cytogenetic changes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wolff, S -- Rodin, B -- New York, N.Y. -- Science. 1978 May 5;200(4341):543-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/644315" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Line ; Chromatids/*drug effects ; Crossing Over, Genetic/*drug effects ; Dose-Response Relationship, Drug ; HeLa Cells ; Saccharin/*pharmacology
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  • 147
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    Production of antibody to tetanus toxoid by continuous human lymphoblastoid cell lines (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-03-31
    Description: Peripheral lymphocytes from human volunteers boosted with tetanus toxoid were cultured after in vitro infection with Epstein-Barr virus. Forty-four continuous lymphoblastoid lines were established which continued to secrete human gamma globulin; seven of these secreted antibody to tetanus toxoid. Subcultures derived from limiting dilution experiments continued to secrete the antibody. Some of these antibody-secreting cells have been in continuous culture for more than 6 months.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zurawski, V R Jr -- Haber, E -- Black, P H -- New York, N.Y. -- Science. 1978 Mar 31;199(4336):1439-41.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/204013" target="_blank"〉PubMed〈/a〉
    Keywords: Antibody Formation ; Antibody Specificity ; Cell Line ; Clone Cells/immunology ; Herpesvirus 4, Human ; Histological Techniques ; Humans ; Lymphocytes/*immunology ; *Tetanus Antitoxin ; *Tetanus Toxoid
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 148
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    Efforts to stop paraquat set back (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-08-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, R J -- New York, N.Y. -- Science. 1978 Aug 4;201(4354):427.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/663666" target="_blank"〉PubMed〈/a〉
    Keywords: Cannabis ; International Cooperation ; *Jurisprudence ; Mexico ; *Paraquat/adverse effects ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 149
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    Budget-cutting mood in Congress begins to hit science (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-07-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, R J -- New York, N.Y. -- Science. 1978 Jul 28;201(4353):330-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/663659" target="_blank"〉PubMed〈/a〉
    Keywords: Government Agencies/*economics ; Legislation as Topic ; *Research Support as Topic ; *Science ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 150
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    Agency drags its feet on warning to pregnant women (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-02-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, R J -- New York, N.Y. -- Science. 1978 Feb 17;199(4330):748-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/622564" target="_blank"〉PubMed〈/a〉
    Keywords: Alcoholic Beverages/*adverse effects ; *Drug Labeling ; Female ; Humans ; *Pregnancy ; United States ; *United States Food and Drug Administration
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 151
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    Immunofluorescent detection of nuclear double-stranded RNA in situ in Vero and mosquito cells (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-06-23
    Description: Double-stranded RNA (dsRNA) was detected in situ by indirect immunofluorescence with antibodies to dsRNA. It was seen in nuclei of Vero and Aedes albopictus cells, but not in BHK cells, KB cells, chick embryo fibroblasts, or HeLa cells. Reactive dsRNA was present in the nucleoplasm, but not in nucleoli or cytoplasm. Extracted RNA from the whole cell contained from 0.08 percent (BHK) to 0.46 percent (HeLa) dsRNA, as estimated by serological methods. This dsRNA, found in molecules having the size distribution of heterogeneous nuclear RNA, did not renature rapidly after denaturation. The quantity of dsRNA in total extracted RNA did not correlate with the presence or absence of nuclear staining in situ.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stollar, B D -- Koo, R -- Stollar, V -- New York, N.Y. -- Science. 1978 Jun 23;200(4348):1381-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26972" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Line ; Cell Nucleolus/analysis ; Cell Nucleus/*analysis ; Culicidae ; Cytoplasm/analysis ; Fluorescent Antibody Technique ; Nucleic Acid Conformation ; RNA/*analysis
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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