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  • Haplorhini  (40)
  • Middle Aged  (39)
  • American Association for the Advancement of Science (AAAS)  (79)
  • American Association of Petroleum Geologists (AAPG)
  • 1975-1979  (79)
  • 1940-1944
Collection
Keywords
Publisher
  • American Association for the Advancement of Science (AAAS)  (79)
  • American Association of Petroleum Geologists (AAPG)
Years
Year
  • 1
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    Metabolism of americium-241 in man: an unusual case of internal contamination of a child and his father (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-10-05
    Description: The metabolism of americium-241 has been studied during an 8-year period in an adult male and his son who, at the ages of 50 and 4 years, respectively, were accidentally and unknowingly contaminated within their home by means of inhalation. Chelation therapy with calcium trisodium pentetate was more effective in enhancing the removal of americium-241 from the child than from the father.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, N -- Sasso, T L -- Wrenn, M E -- New York, N.Y. -- Science. 1979 Oct 5;206(4414):64-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/482925" target="_blank"〉PubMed〈/a〉
    Keywords: Age Factors ; Americium/*metabolism/poisoning ; Body Burden ; Body Height ; Body Weight ; Bone and Bones/metabolism ; Chelating Agents/*therapeutic use ; Child, Preschool ; Humans ; Liver/metabolism ; Lung/metabolism ; Male ; Middle Aged
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Ingested mineral fibers: elimination in human urine (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-04-13
    Description: Sediment in human urine examined by transmission electron microscopy contains amphibole fibers which originate from the ingestion of drinking water contaminated with these mineral fibers. The ingestion of filtered water results in the eventual disappearance of amphibole fibers from urine. These observations provide the first direct evidence for the passage of mineral fibers through the human gastro-intestinal mucosa under normal conditions of the alimentary canal.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cook, P M -- Olson, G F -- New York, N.Y. -- Science. 1979 Apr 13;204(4389):195-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/219478" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Aged ; Female ; Gastric Mucosa/metabolism ; Humans ; Intestinal Absorption ; Intestinal Mucosa/metabolism ; Male ; Middle Aged ; Silicon Dioxide/metabolism/*urine ; *Water Pollutants ; *Water Pollutants, Chemical
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    Enchancement of luminance flicker by color-opponent mechanisms (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-10
    Description: Color-opponent ganglion cells in the monkey retina respond to luminance flicker at high temporal frequencies. Color opponency, which makes these cells so selective of wavelength at low temporal frequencies, is progressively lost at high frequencies. This loss is due to a frequency-dependent phase shift between the responses of spectrally different center and surround mechanisms in the receptive field of each of these cells. Center and surround responses, which are antagonistic at low temporal frequencies, become synergistic at high ones, making these cells most responsive at high frequencies to those wavelengths to which they are least responsive at low frequencies. This phenomenon can explain the differences between chromatic and luminance flicker in human vision.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gouras, P -- Zrenner, E -- New York, N.Y. -- Science. 1979 Aug 10;205(4406):587-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/109925" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Color ; Ganglia/*physiology ; Haplorhini ; Light ; Retina/*physiology ; *Vision, Ocular
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Cerebellar plasticity: modification of Purkinje cell structure by differential rearing in monkeys (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-10-12
    Description: Dendritic branching in Purkinje and granule cells and the diameters of Purkinje cell somas were compared in several cerebellar areas of monkeys reared in isolation, with social experience, or in a large colony. In the colony-reared monkeys, spiny branchlets of Purkinje cells were more extensive in the paraflocculus and the nodulus than they were in the other two groups. Granule cell dendritic branching in the paraflocculus and nodulus did not differ across groups. In addition, Purkinje cell somas were larger in the uvula and the nodulus of the colony animals than in the other groups. These data indicate that the social and physical environment during development influences the morphology of cerebellar Purkinje cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Floeter, M K -- Greenough, W T -- New York, N.Y. -- Science. 1979 Oct 12;206(4415):227-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/113873" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal/*physiology ; Cerebellum/*growth & development ; Dendrites/ultrastructure ; Environment ; Haplorhini ; Macaca fascicularis ; Movement ; Purkinje Cells/*cytology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Stimulation of human periaqueductal gray for pain relief increases immunoreactive beta-endorphin in ventricular fluid (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-01-19
    Description: Immunoreactive beta-endorphin was measured in the ventricular fluid of six patients with chronic pain. Stimulation of the periaqueductal gray matter in three patients with pain of peripheral origin resulted in significant increases (50 to 300 percent) in the concentration of ventricular immunoreactive beta-endorphin. In three other patients suffering deafferentation dysesthesia, stimulation of the posterior limb of the internal capsule did not alter the concentration of this peptide. These results provide evidence of the release of human immunoreactive beta-endorphin in vivo and suggest that naloxone-reversible pain relief achieved by stimulation of the periaqueductal gray matter may be in part mediated by the activation of beta-endorphin-rich diencephalic areas.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hosobuchi, Y -- Rossier, J -- Bloom, F E -- Guillemin, R -- New York, N.Y. -- Science. 1979 Jan 19;203(4377):279-81.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/83674" target="_blank"〉PubMed〈/a〉
    Keywords: Aged ; Brain/*physiology ; Cerebral Aqueduct ; Electric Stimulation ; Endorphins/*cerebrospinal fluid/immunology ; Enkephalins/cerebrospinal fluid ; Female ; Humans ; Male ; Middle Aged ; Palliative Care/methods ; Radioimmunoassay
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    3-Methoxy-4-hydroxyphenethyleneglycol production by human brain in vivo (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-07
    Description: A direct method has been employed to estimate the rate of production by human brain of 3-methoxy-4-hydroxyphenethyleneglycol, the major metabolite of brain norepinephrine, a brain neurotransmitter. Venous specimens were obtained from the internal jugular vein from ten awake human subjects at a puncture site above the common facial vein, the first major source of extracranial inflow. Arterial specimens were simultaneously obtained from the radial artery. Plasma samples were assayed and a highly significant difference was found in the concentration of the metabolite in plasma coming out of the brain (venous blood) as compared to plasma entering the brain (arterial blood). This venous-arterial difference was calculated to be 0.7 +/- 0.1 nanogram per milliliter of blood. Assuming an adult brain weight of 1400 grams and normal cerebral blood flow, it is estimated that the rate of production of 3-methoxy-4-hydroxyphenethyleneglycol by the awake human brain is approximately 597 nanograms per minute or 35.8 micrograms per hour. Urine specimens were also collected from six of these subjects during a period of 1 to 3.5 hours, which bracketed the time the blood samples were obtained. For these six subjects the output of 3-methyoxy-4-hydroxyphenethyleneglycol by whole brain was estimated to be 40.9 micrograms per hour, whereas the rate of its excretion into urine was 64.5 micrograms per hour.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maas, J W -- Hattox, S E -- Greene, N M -- Landis, D H -- New York, N.Y. -- Science. 1979 Sep 7;205(4410):1025-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472724" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Brain/*metabolism ; Cerebrovascular Circulation ; Female ; Glycols/*metabolism ; Humans ; Male ; Methoxyhydroxyphenylglycol/blood/*metabolism/urine ; Middle Aged ; Norepinephrine/metabolism
    Print ISSN: 0036-8075
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  • 7
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    Sex hormones and brain development (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G B -- New York, N.Y. -- Science. 1979 Sep 7;205(4410):985-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/112680" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenocortical Hyperfunction/physiopathology ; Animals ; Behavior/*physiology ; Behavior, Animal/physiology ; Brain/*growth & development ; Female ; Gonadal Steroid Hormones/*physiology ; Haplorhini ; Humans ; Male ; Preoptic Area/growth & development ; Rats ; Receptors, Estrogen/metabolism ; Sex Differentiation ; Testosterone/metabolism
    Print ISSN: 0036-8075
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  • 8
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    The annual Pap smear: an idea whose time has gone? (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-07-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J L -- New York, N.Y. -- Science. 1979 Jul 13;205(4402):177-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451586" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Female ; Humans ; Mass Screening/*economics ; Middle Aged ; *Papanicolaou Test ; Risk ; Socioeconomic Factors ; Uterine Cervical Neoplasms/epidemiology/*prevention & control ; Vaginal Smears/*economics
    Print ISSN: 0036-8075
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  • 9
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    The HDL: the good cholestrol carriers? (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J L -- New York, N.Y. -- Science. 1979 Aug 17;205(4407):677-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/223241" target="_blank"〉PubMed〈/a〉
    Keywords: Age Factors ; Cholesterol/*blood/metabolism ; Diet ; Female ; Humans ; Lipoproteins, HDL/*blood ; Lipoproteins, LDL/blood ; Male ; Middle Aged ; Myocardial Infarction/etiology ; Risk ; Running ; Sex Factors ; Tissue Distribution
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    Pharmacologic effects in man of a potent, long-acting dopamine receptor agonist (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-14
    Description: Single-dose administration of pergolide mesylate (100 to 400 micrograms) results in a dose-related inhibition of prolactin secretion which persists for more than 24 hours. During multiple-dose administration of pergolide, plasma prolactin concentrations remain markedly reduced (greater than 80 percnet) and gradually return to control levels several days after drug administration is discontinued.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lemberger, L -- Crabtree, R E -- New York, N.Y. -- Science. 1979 Sep 14;205(4411):1151-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/382359" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Clinical Trials as Topic ; Dose-Response Relationship, Drug ; Ergolines/*pharmacology/therapeutic use ; Humans ; Informed Consent ; Male ; Middle Aged ; Placebos ; Prolactin/blood ; Receptors, Dopamine/*drug effects ; Time Factors
    Print ISSN: 0036-8075
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  • 11
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    Thalamic and cortical afferents differentiate anterior from posterior cingulate cortex in the monkey (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-04-13
    Description: The anterior cingulate cortex receives thalamic afferents mainly from the midline and intralaminar nuclei rather than the anterior thalamic nuclei. In contrast, the posterior cingulate cortex receives afferents primarily from the anterior thalamic nuclei and from extensive cortical areas in the frontal, parietal, and temporal lobes. These contrasting afferents may provide a structural basis for pain-related functions of the anterior cingulate cortex.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vogt, B A -- Rosene, D L -- Pandya, D N -- New York, N.Y. -- Science. 1979 Apr 13;204(4389):205-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/107587" target="_blank"〉PubMed〈/a〉
    Keywords: Afferent Pathways/cytology ; Animals ; Brain Mapping ; Cerebral Cortex/*cytology ; Gyrus Cinguli/*cytology/physiology ; Haplorhini ; Horseradish Peroxidase ; Macaca mulatta ; Thalamic Nuclei/*cytology
    Print ISSN: 0036-8075
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  • 12
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    Phase advance of the circadian sleep-wake cycle as an antidepressant (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-09
    Description: Sleep in depressed patients resembles sleep in normal subjects whose circadian rhythms of temperature and rapid-eye-movement sleep are phase-advanced (shifted earlier) relative to their sleep schedules. If this analogy is relevant to the pathophysiology of depressive illness, advancing the time of sleep and awakening should temporarily compensate for the abnormal timing of depressed patients' circadian rhythms. Four of seven manic-depressive patients studied longitudinally spontaneously advanced their times of awakening (activity onset) as they emerged from the depressive phase of their illness. In a phase-shift experiment, a depressed manic-depressive woman was twice brought out of depression for 2 weeks by advancing her sleep period so that she went to sleep and arose 6 hours earlier than usual. The antidepressant effect of the procedure was temporary and similar in duration to circadian desynchronization induced by jet lag in healthy subjects. This result supports the hypothesis that abnormalities of sleep patterns in some types of depression are due to abnormal internal phase relationships of circadian rhythms.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wehr, T A -- Wirz-Justice, A -- Goodwin, F K -- Duncan, W -- Gillin, J C -- New York, N.Y. -- Science. 1979 Nov 9;206(4419):710-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/227056" target="_blank"〉PubMed〈/a〉
    Keywords: Bipolar Disorder/*physiopathology/therapy ; Body Temperature Regulation ; *Circadian Rhythm ; Female ; Humans ; Middle Aged ; Motor Activity/physiology ; Sleep, REM/*physiology
    Print ISSN: 0036-8075
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  • 13
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    Species-specific perceptual processing of vocal sounds by monkeys (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-05-25
    Description: Monkeys of four species were trained to discriminate between sets of natural tonal calls of Japanese macaques (Macaca fuscata) by the position of a frequency-inflection peak or by initial pitch. The Japanese macaques consistently performed best on peak position and the other species on pitch. The results imply special strategies for perceptional processing of vocal sounds and suggest parallels with human speech perception.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zoloth, S R -- Petersen, M R -- Beecher, M D -- Green, S -- Marler, P -- Moody, D B -- Stebbins, W -- New York, N.Y. -- Science. 1979 May 25;204(4395):870-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/108805" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Auditory Perception/*physiology ; Haplorhini ; Macaca/*physiology ; Species Specificity ; Speech Perception/*physiology ; Vocalization, Animal/*physiology
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  • 14
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    Orientation anisotropy of visual stimuli in rhesus monkey: a behavior study (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-03
    Description: The contrast sensitivity of the rhesus monkey was tested, according to a modified reaction-time paradigm, for sine-wave grating targets at different orientations. The monkey possesses an oblique effect slightly larger than that of humans. A reaction time analysis showed the oblique effect to be a suprathreshold as well as a threshold phenomenon. The presence of this effect further strengthens the use of the monkey as a model for the human visual system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Boltz, R L -- Harwerth, R S -- Smith, E L 3rd -- R01 EY001139/EY/NEI NIH HHS/ -- New York, N.Y. -- Science. 1979 Aug 3;205(4405):511-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/109923" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal ; Haplorhini ; Humans ; Macaca mulatta ; Species Specificity ; *Visual Perception
    Print ISSN: 0036-8075
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  • 15
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    Menopausal flushes: a neuroendocrine link with pulsatile luteninizing hormone secreation (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-24
    Description: Menopausal flush episodes were found to be invariably associated with the initiation of pulsatile pituitary release of luteinizing hormone. This was not accompanied by a significant change in circulating catecholamine or prolactin concentrations. Since pulsatile luteinizing hormone release results from episodic secretion of luteinizing hormone releasing factor by the hypothalamus, these findings suggest a link between the neuroendocrine mechanisms that initiate such episodic secretion and those responsible for the onset of flush episodes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Casper, R F -- Yen, S S -- Wilkes, M M -- New York, N.Y. -- Science. 1979 Aug 24;205(4408):823-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/462193" target="_blank"〉PubMed〈/a〉
    Keywords: *Climacteric ; Dopamine/blood ; Epinephrine/blood ; Female ; Follicle Stimulating Hormone/blood ; Humans ; Luteinizing Hormone/blood/*secretion ; Middle Aged ; Norepinephrine/blood ; Prolactin/blood
    Print ISSN: 0036-8075
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  • 16
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    Target velocity signals of visual tracking in vermal Purkinje cells of the monkey (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-17
    Description: Discharges of Purkinje cells were recorded from the vermis, lobules VI and VII, of a monkey trained to track a visual target. When the monkey tracked a sinusoidally oscillating target, cellular activity changes in phase with the velocity signal of the eye movement. When the monkey fixated a stationary point, almost identical modulation in activity occurred, reflecting the velocity signal of the motion of the retinal image of the target. The data suggest that the vermis participates in the control of smooth pursuit eye movements by providing the oculomotor system with the actual target velocity information which is the sum of eye velocity and retinal image velocity signals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kase, M -- Noda, H -- Suzuki, D A -- Miller, D C -- New York, N.Y. -- Science. 1979 Aug 17;205(4407):717-20.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/111350" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; *Eye Movements ; Haplorhini ; Motion Perception/physiology ; Proprioception ; Purkinje Cells/*physiology ; Visual Perception/*physiology
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  • 17
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    Subicular input from temporal cortex in the rhesus monkey (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-10
    Description: The subicular cortices of the primate hippocampal formation form a physical and connectional link between the cortex of the temporal lobe and the hippocampus. Their direct connections with all classes of cortex in the temporal lobe except primary sensory cortex underscore the pivotal role of these areas in the potential interplay between the hippocampal formation and the association cortices.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Van Hoesen, G W -- Rosene, D L -- Mesulam, M M -- New York, N.Y. -- Science. 1979 Aug 10;205(4406):608-10.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/109926" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acids/metabolism ; Animals ; Haplorhini ; Hippocampus/anatomy & histology/*physiology ; Macaca mulatta ; Temporal Lobe/anatomy & histology/*physiology
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  • 18
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    Physostigmine and recent memory: effects in young and aged nonhuman primates (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-30
    Description: The effect of physostigmine on recent memory was evaluated in young and aged rhesus monkeys. All aged monkeys had previously shown impaired memory. The performance of the young monkeys treated with physostigmine was similar to that recently reported for young humans--no effects at low doses, some improvement at a restricted range of doses, and deficits at the highest dose. Although the aged subjects also improved at the same general doses, their overall response as a group was much more variable than that of the younger subjects. The performance of some aged monkeys was impaired by low doses that did not affect young monkeys. Continued improvement was observed in some aged monkeys at the highest dose, which typically impaired young monkeys. These variable effects across aged subjects suggest that physostigmine cannot easily or reliably be used as an agent for treating geriatric cognition. Nevertheless, the differential age-related effects suggest that appropriate manipulation of the cholinergic system may eventually be developed to alleviate some of the cognitive impairments suffered by aged subjects.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bartus, R T -- New York, N.Y. -- Science. 1979 Nov 30;206(4422):1087-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/227061" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylcholine/physiology ; Aging ; Animals ; Cognition/physiology ; Female ; Haplorhini ; Humans ; Male ; Memory/*drug effects ; Memory Disorders/drug therapy ; Memory, Short-Term/drug effects ; Physostigmine/*pharmacology/therapeutic use ; Synaptic Transmission
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  • 19
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    Selective phospholipid adsorption and atherosclerosis (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-05-04
    Description: Disaturated (fully saturated) lecithins adsorb onto solid surfaces more readily than lecithins in which one or both fatty acids are unsaturated. If saturated lecithins adsorb to arterial walls as they do to glass and polystyrene surfaces, there may be increased probability of atherosclerosis when the disaturated lecithin content of plasma is elevated. Analyses of lecithins in plasma samples from patients with myocardial infarction, and from patients with premature atherosclerosis but with low concentrations of plasma cholesterol and triglycerides, are consistent with the hypothesis that a high concentration of disaturated lecithin in plasma may be a significant risk factor for atherosclerosis, independent of triglyceride and cholesterol concentrations.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gershfeld, N L -- New York, N.Y. -- Science. 1979 May 4;204(4392):506-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/581915" target="_blank"〉PubMed〈/a〉
    Keywords: Adsorption ; Adult ; Aged ; Arteriosclerosis/blood/*etiology ; Coronary Disease/*blood ; Fatty Acids, Unsaturated ; Female ; Humans ; Male ; Middle Aged ; Myocardial Infarction/blood ; *Phosphatidylcholines/blood ; Pulmonary Surfactants/blood ; Structure-Activity Relationship ; Temperature
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  • 20
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    Inhibition of gonadotropin by delta9-tetrahydrocannabinol:mediation by steroid receptors? (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-04-20
    Description: Competition assays for estradiol receptors in cytosol preparations of uteri from rhesus monkeys and humans showed that delta9-tetrahydrocannabinol (THC) does not compete with estradiol for intracellular estrogen recptors. Although isotopically labeled THC bound to macromolecules in uterine cytosol from the rhesus monkey, the binding was not displaced by unlabeled THC, diethylstilbestrol, estradiol, progesterone, cortisol, or 5 alpha-dihydrostestosterone. Scatchard analyses indicated that high-affinity saturable binding of THC to cytosol did not occur. Thus the inhibitory effect of THC on gonadotropin and steroid secretion in primates is not mediated by the interaction of THC with intracellular steroid hormone receptors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, R G -- Besch, N F -- Besch, P K -- Smith, C G -- New York, N.Y. -- Science. 1979 Apr 20;204(4390):325-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/107589" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Binding, Competitive ; Cytosol/metabolism ; Diethylstilbestrol/metabolism ; Dronabinol/*pharmacology ; Estradiol/metabolism ; Female ; Haplorhini ; Humans ; Receptors, Estrogen/*drug effects/metabolism ; Steroids/metabolism ; Uterus/*metabolism
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  • 21
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    Isolation and characterization of an endogenous type C virus of rhesus monkeys (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-05-25
    Description: A type C retrovirus was isolated from a continuous cell line established from a spontaneous esophageal carcinoma of a rhesus monkey (Macaca mulata) by prolonged cocultivation with canine cells. A DNA transcript of the viral RNA hybridized to a high level and kinetic analysis indicated the presence of multiple copies of the viral genome in rhesus monkey DNA, showing that the virus is endogenous in this species. The rhesus monkey virus closely resembles, in several respects, an endogenous type C virus previously isolated from stumptailed macques (Macaca arctoides), aa species closely related to rhesus monkeys.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rabin, H -- Benton, C V -- Tainsky, M A -- Rice, N R -- Gilden, R V -- New York, N.Y. -- Science. 1979 May 25;204(4395):841-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/87013" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Haplorhini ; Macaca/*microbiology ; Macaca mulatta/*microbiology ; Nucleic Acid Hybridization ; RNA, Viral/analysis ; RNA-Directed DNA Polymerase/metabolism ; Retroviridae/enzymology/*isolation & purification/ultrastructure ; Viral Proteins/analysis/immunology
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  • 22
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    Inhibitory, GABAergic nerve terminals decrease at sites of focal epilepsy (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-07-13
    Description: Using an immunocytochemical method for the localization of the gamma-aminobutyric acid (GABA) synthesizing enzyme, glutamic acid decarboxylase (GAD), we have observed GABAergic nerve terminals distributed throughout all layers of normal monkey sensorimotor cortex. These terminals displayed ultrastructural characteristics that suggested that they arose from aspinous and sparsely spinous stellate neurons. In monkeys (Macaca mulatta and M. fascicularis) made epileptic by cortical application of alumina gel, a highly significant numerical decrease of GAD-positive nerve terminals occurred at sites of seizure foci indicating a functional loss of GABAergic inhibitory synapses. A loss of such inhibition at seizure foci could lead to epileptic activity of cortical pyramidal neurons.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ribak, C E -- Harris, A B -- Vaughn, J E -- Roberts, E -- New York, N.Y. -- Science. 1979 Jul 13;205(4402):211-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/109922" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Carboxy-Lyases/*metabolism ; Cerebral Cortex/*metabolism ; Epilepsies, Partial/*physiopathology ; Glutamate Decarboxylase/*metabolism ; Glutamates/metabolism ; Haplorhini ; Macaca fascicularis ; Macaca mulatta ; Motor Cortex/metabolism ; Nerve Endings/enzymology ; gamma-Aminobutyric Acid/metabolism
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  • 23
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    Erythrocytes: a new cell type for the evaluation of insulin receptor defects in diabetic humans (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-07-13
    Description: Human erythrocytes have specific insulin receptors. When studied in an insulin radioreceptor assay, erythrocytes from adult-onset, nonobese diabetic subjects bound at least 42 percent less insulin than the normal subjects at insulin concentrations from 0.1 to 100 nanograms per milliliter. The diabetic subjects had 190 insulin receptor sites per cell as compared with the 380 insulin receptor sites per cell for the normal subjects. The deficit of insulin binding in the diabetic subject was thus associated with a fewer number of insulin binding sites per cell with little or no change in affinity. The erythrocyte is a readily available cell for the evaluation of cellular insulin receptor activity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Robinson, T J -- Archer, J A -- Gambhir, K K -- Hollis, V W Jr -- Carter, L -- Bradley, C -- New York, N.Y. -- Science. 1979 Jul 13;205(4402):200-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451590" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Aged ; Diabetes Mellitus/*blood/metabolism ; Erythrocyte Membrane/*metabolism ; Erythrocytes/*metabolism ; Female ; Humans ; Insulin/metabolism ; Male ; Middle Aged ; Receptor, Insulin/*metabolism
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    Plasma beta-endorphin immunoreactivity in schizophrenia (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-09-14
    Description: Plasma beta-endorphin-like immunoreactivity was measured by a method that was equally sensitive to beta-endorphin and [Leu5]-beta-endorphin. Immunoreactivity in 98 schizophrenic patients did not differ greatly from that in 42 normal subjects. No immunoreactivity was detectable in dialyzates from first-time hemodialysis of eight nonpsychotic renal patients and nine schizophrenic patients. These results are not compatible with recent reports of extremely high concentrations of [Leu5]-beta-endorphin in hemodialyzates from schizophrenic patients.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ross, M -- Berger, P A -- Goldstein, A -- New York, N.Y. -- Science. 1979 Sep 14;205(4411):1163-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472735" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Aged ; Endorphins/*blood/immunology ; Female ; Humans ; Male ; Middle Aged ; Radioimmunoassay ; Schizophrenia/*blood ; Stress, Physiological/blood
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  • 25
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    Effects of frontal eye field and superior colliculus ablations on eye movements (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-02
    Description: Two parallel neural pathways are primarily responsible for the control of saccadic eye movements--one mediated through the frontal eye fields and the other through the superior colliculus. When both pathways are disrupted, control of saccadic eye movements is lost. Disruption of either pathway alone produces only subtle deficits.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schiller, P H -- True, S D -- Conway, J L -- New York, N.Y. -- Science. 1979 Nov 2;206(4418):590-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/115091" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain Mapping ; *Eye Movements ; Frontal Lobe/*physiology ; Haplorhini ; Neural Pathways/physiology ; Reflex/physiology ; Saccades ; Superior Colliculi/*physiology ; Vestibule, Labyrinth/physiology
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  • 26
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    Behavior maintained by termination of a schedule of self-administered cocaine (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-06-15
    Description: Squirrel monkeys self-administered cocaine by pressing a lever while under a variable-interval schedule of reinforcement. At the same time, they terminated the availability of self-administered cocaine by pressing a second lever while under a fixed-interval schedule of reinforcement. The maintenance of behavior by schedule drug injections and by termination of scheduled drug injections, usually considered to be processes associated with different classes of drugs, can occur simultaneously when behavior is controlled by different contingencies associated with a single drug.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Spealman, R D -- New York, N.Y. -- Science. 1979 Jun 15;204(4398):1231-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/109920" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal/*drug effects ; Cocaine/*pharmacology ; Disease Models, Animal ; Haplorhini ; Humans ; Male ; Reinforcement (Psychology) ; Saimiri ; Self Administration/psychology ; Substance-Related Disorders/physiopathology
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  • 27
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    Primate olfactory behavior (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-03-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1979 Mar 16;203(4385):1139-40.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/106469" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal/*physiology ; Haplorhini ; Macaca mulatta/physiology ; Male ; Pheromones ; Smell/*physiology
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  • 28
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    Dendritic growth in the aged human brain and failure of growth in senile dementia (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-11-16
    Description: Golgi-stained dendrites of single randomly chosen layer-II pyramidal neurons in the human parahippocampal gyrus were quantified with a computer-microscope system. In nondemented aged cases (average age, 79.6 years), dendritic trees were more extensive than in adult cases (average age, 51.2), with most of the difference resulting from increases in the number and average length of terminal segments of the dendritic tree. These results provide morphological evidence for plasticity in the mature and aged human brain. In senile dementia (average age, 76.0), dendritic trees were less extensive than in adult brains, largely because their terminal segments were fewer and shorter. Cells with shrunken dendritic trees were found in all brains. These data suggest a model of aging in the central nervous system in which one population of neurons dies and regresses and the other survives and grows. The latter appears to be the dominant population in aging without dementia.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Buell, S J -- Coleman, P D -- New York, N.Y. -- Science. 1979 Nov 16;206(4420):854-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493989" target="_blank"〉PubMed〈/a〉
    Keywords: Aged ; *Aging ; Cells, Cultured ; Dementia/pathology/*physiopathology ; Dendrites/pathology/physiology/ultrastructure ; Hippocampus/pathology ; Humans ; Middle Aged
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  • 29
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    Cognitive deficit caused by regional depletion of dopamine in prefrontal cortex of rhesus monkey (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-31
    Description: Depletion of dopamine in a circumscribed area of association cortex in rhesus monkeys produces an impairment in spatial delayed alternation performance nearly as severe as that caused by surgical ablation of the same area. This behavioral deficit can be pharmacologically reversed with dopamine agonists such as L-dopa and apomorphine. These data provide direct evidence that dopamine plays an important role in a specific cortical function.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brozoski, T J -- Brown, R M -- Rosvold, H E -- Goldman, P S -- New York, N.Y. -- Science. 1979 Aug 31;205(4409):929-32.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/112679" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Apomorphine/pharmacology ; Behavior, Animal/drug effects/physiology ; Cerebral Cortex/*physiology ; Cognition/drug effects/*physiology ; Dihydroxyphenylalanine/analogs & derivatives/pharmacology ; Dopamine/*physiology ; Dose-Response Relationship, Drug ; Haplorhini ; Levodopa/pharmacology ; Macaca mulatta ; Norepinephrine/physiology
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  • 30
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    Smoking impairs long-term dust clearance from the lung (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-05-04
    Description: The time for the long-term clearance of dust from human lungs was measured. Three heavy cigarette smokers and nine nonsmokers inhaled a harmless trace amount of magnetic dust, Fe3O4. From periodic measurements with a sensitive magnetic detector of the amount of this dust remaining in the lungs, a clearance curve was determined for each subject. This magnetic tracer method allows clearance to be safely followed for a much longer time than with radioactive tracer methods. The dust clearance in the smokers is considerably slower than in the nonsmokers. After about a year, 50 percent of the dust originally deposited remained in the lungs of the smokers whereas only 10 percent remained in the lungs of the nonsmokers. The smokers therefore retained five times more dust than the nonsmokers. This impaired clearance of Fe3O4 suggests impaired clearance in smokers of other dusts, such as toxic occupational and urban dusts. The higher retention of these dusts may contribute to the higher incidence of lung diseases in smokers.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, D -- Arai, S F -- Brain, J D -- New York, N.Y. -- Science. 1979 May 4;204(4392):514-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/432655" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; *Dust ; Humans ; Iron ; Lung/*physiopathology ; Lung Compliance ; Magnetics ; Male ; Middle Aged ; Smoking/*physiopathology
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  • 31
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    Dopamine-related tetrahydroisoquinolines: significant urinary excretion by alcoholics after alcohol consumption (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-12-07
    Description: Concentrations of dopamine-related tetrahydroisoquinolines (salsolinol and O-methylated salsolinol) were significantly higher in the daily urine samples of alcoholic subjects admitted for alcohol detoxification than in the daily urine samples of nonalcoholic control subjects. Salsolinol concentrations in alcoholic subjects appeared to drop to trace (control) values 2 to 3 days after admission, following the disappearance of ethanol and its reactive metabolite acetaldehyde from the blood. These results indicate that physiologically active tetrahydroisoquinolines increase in humans during long-term alcohol consumption, presumably because of acetaldehyde's direct condensation with catecholamines. The presence of these or similar condensation products in the urine could be useful as clinical indicators of prior blood acetaldehyde concentrations in chronic alcoholics.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Collins, M A -- Nijm, W P -- Borge, G F -- Teas, G -- Goldfarb, C -- New York, N.Y. -- Science. 1979 Dec 7;206(4423):1184-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/505002" target="_blank"〉PubMed〈/a〉
    Keywords: Acetaldehyde/blood ; Adult ; Alcoholism/metabolism/*urine ; Dopamine/*metabolism ; Humans ; Isoquinolines/*urine ; Male ; Middle Aged ; Salsoline Alkaloids/urine ; Substance Withdrawal Syndrome/urine
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  • 32
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    Cadmium: in vivo measurement in smokers and nonsmokers (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-07-20
    Description: Absolute amounts of cadmium (in milligrams) in the left kidney and concentrations of cadmium (micrograms per gram) in the liver were measured in vivo in 20 healthy adult male volunteers. Organ cadmium levels of smokers were significantly elevated above those of nonsmokers. No relationship was evident between body stores of cadmium (liver and kidney) and cadmium or beta 2-microglobulin in urine or blood. The average total body burden of cadmium in man at age 50 is estimated to be 19.3 milligrams for nonsmokers and 35.5 milligrams for smokers (38.7 pack-year smoking history). Biological half-time for the whole body was, on average, 15.7 years (10- to 33-year range). Dietary absorption was 2.7 micrograms per day. Cigarette smoking resulted in the absorption of 1.9 micrograms per pack.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ellis, K J -- Vartsky, D -- Zanzi, I -- Cohn, S H -- Yasumura, S -- New York, N.Y. -- Science. 1979 Jul 20;205(4403):323-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/377488" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Cadmium/*analysis ; Diet ; Humans ; Kidney/analysis ; Liver/analysis ; Male ; Middle Aged ; Neutron Activation Analysis ; Smoking/*physiopathology ; Tissue Distribution ; beta 2-Microglobulin/urine
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    Agent orange furor continues to build (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-08-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1979 Aug 24;205(4408):770-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/111351" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Defoliants, Chemical/*poisoning ; Dioxins/*poisoning ; Haplorhini ; Herbicides/*poisoning ; Humans ; Male ; *Military Medicine ; Vietnam
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  • 34
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    Antibodies to sporozoites: their frequent occurrence in individuals living in an area of hyperendemic malaria (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-11-02
    Description: Serum samples from 158 West Africans were tested for antibodies against sporozoites, the vector stage of the malaria parasite. Antibodies specific for Plasmodium falciparum sporozoites were detected by means of the circumsporozoite precipitation assay and indirect immunofluorescence. More than 90 percent of the serum samples from adults gave positive immunofluorescent reactions against falciparum sporozoites, whereas most of the samples from children gave low or negative reactions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nardin, E H -- Nussenzweig, R S -- McGregor, I A -- Bryan, J H -- New York, N.Y. -- Science. 1979 Nov 2;206(4418):597-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/386511" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Age Factors ; Antibodies/*analysis ; Child ; Child, Preschool ; Disease Reservoirs/immunology ; Fluorescent Antibody Technique ; Humans ; Malaria/*immunology ; Middle Aged ; Plasmodium falciparum/*immunology ; Vaccines
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    Electromagnetic muscle stretch strongly excites sensorimotor cortex neurons in behaving primates (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-02-02
    Description: Responses of single units in primary motor and sensory cortex of behaving primates to electromagnetic stretch of the muscle flexor carpi ulnaris are comparable in latency and intensity to responses to wrist extension. Thus, muscle stretch appears to be a major factor in cortical response to limb displacement during performance and probably has an important role in motor control at the cortical level.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wolpaw, J R -- New York, N.Y. -- Science. 1979 Feb 2;203(4379):465-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/104385" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arm ; Cerebral Cortex/*physiology ; Electromagnetic Phenomena ; Haplorhini ; Macaca mulatta ; Motor Cortex/*physiology ; *Movement ; Muscles/*innervation ; Neurons/physiology ; Proprioception
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    Reversible cerebral atrophy in recently abstinent chronic alcoholics measured by computed tomography scans (1978)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1978-06-02
    Description: Eight chronic alcoholics received repeated computed tomography scans. Four, who maintained abstinence and functionally improved, showed partially reversible cerebral atrophy. Two nonabstinent patients and two abstinent patients who had completed functional improvement before the first scan showed no change in atrophy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carlen, P L -- Wortzman, G -- Holgate, R C -- Wilkinson, D A -- Rankin, J C -- New York, N.Y. -- Science. 1978 Jun 2;200(4345):1076-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/653357" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Aged ; Alcoholism/*pathology/radiography/therapy ; Atrophy ; Brain/*pathology/radiography ; Female ; Humans ; Male ; Middle Aged ; Tomography, X-Ray Computed
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    Functional plasticity in the immature striate cortex of the monkey shown by the [14C]deoxyglucose method (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-04-28
    Description: Autoradiographic representation of the local rates of cerebral glucose utilization and local cerebral functional activity by means of the [14C]deoxyglucose technique reveals the existence of the ocular dominance columns in the striate cortex of the monkey in the first day of life. In contrast to the stability of these columns in more mature brain, monocular deprivation for 3 months from the first day of life results in their complete disappearance and a reversion of the autoradiographic pattern to that seen in animals with normal binocular vision. These results are consistent with a reorganization of the representation of the visual fields of the two eyes in the striate cortex and provide additional evidence of the plasticity of the striate cortex of the monkey in early life.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Des Rosiers, M H -- Sakurada, O -- Jehle, J -- Shinohara, M -- Kennedy, C -- Sokoloff, L -- New York, N.Y. -- Science. 1978 Apr 28;200(4340):447-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/417397" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Newborn/physiology ; Brain Mapping ; Cell Differentiation ; Deoxy Sugars/*metabolism ; Deoxyglucose/*metabolism ; Female ; Haplorhini ; Male ; Vision, Ocular ; Visual Cortex/*cytology/physiology ; Visual Pathways/*cytology/physiology
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    Thermoregulation is impaired in an environment without circadian time cues (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-02-17
    Description: Squirrel monkeys synchronized to a 24-hour light-dark cycle show a prominent circadian rhythm in body temperature which is regulated against mild environmental cold exposures throughout the 24-hour day. However, cold exposures produce significant decreases in core body temperature when the circadian rhythms of the animal are free-running in the absence of environmental time cues. Effective thermoregulation appears to require the precise internal synchronization of the circadian timekeeping system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fuller, C A -- Sulzman, F M -- Moore-Ede, M C -- New York, N.Y. -- Science. 1978 Feb 17;199(4330):794-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/414356" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Body Temperature Regulation ; *Circadian Rhythm ; Cold Temperature ; Cues ; *Environment ; Environmental Exposure ; Haplorhini ; Homeostasis ; Male ; Saimiri ; Time Factors
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  • 39
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    Neuronal plasticity in primate telencephalon: anomalous projections induced by prenatal removal of frontal cortex (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-11-17
    Description: When the dorsolateral prefrontal cortex in one hemisphere of a rhesus monkey is resected 6 weeks before birth and the fetus survives to postnatal ages, neurons of the corresponding cortex in the intact hemisphere issue a greatly expanded projection to the contralateral caudate nucleus in addition to a normal projection to the ipsilateral caudate. The enhancement of the crossed prefronto-caudate pathway after prenatal neurosurgery provides direct evidence for lesion-induced neuronal rearrangement in the primate telencephalon.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goldman, P S -- New York, N.Y. -- Science. 1978 Nov 17;202(4369):768-70.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/102031" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Axons/ultrastructure ; Brain/embryology/growth & development ; Brain Mapping ; Cell Differentiation ; Cerebral Cortex/*cytology ; Haplorhini ; Macaca mulatta ; Neural Pathways/*cytology ; Synapses/*ultrastructure
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  • 40
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    Decrease of human serum fucosyltransferase as an indicator of successful tumor therapy (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-09-29
    Description: Surgical removal of colon carcinomas leads to a decrease in the rate of incorporation of [14C]fucose into its endogenous acceptor in human serum; normal incorporation rates are attained within 14 days. A similar time course has been determined for alpha2- and alpha3-fucosyltransferase when either desialo- or desialodegalactofetuin are employed as exogenous acceptors. A correlation has also been seen between transferase activity and the therapeutic response of patients with breast cancer. These results indicate that the determination of fucosyltransferase activity can facilitate the diagnosis of neoplasia, and the success of surgery, chemotherapy, or radiation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bauer, C H -- Reutter, W G -- Erhart, K P -- Kottgen, E -- Gerok, W -- New York, N.Y. -- Science. 1978 Sep 29;201(4362):1232-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/694511" target="_blank"〉PubMed〈/a〉
    Keywords: Aged ; Breast Neoplasms/*therapy ; Carcinoma/blood/*surgery ; Colonic Neoplasms/blood/*surgery ; Female ; Fucosyltransferases/*blood ; Hexosyltransferases/*blood ; Humans ; Male ; Middle Aged
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  • 41
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    Hypophysial responses to continuous and intermittent delivery of hypopthalamic gonadotropin-releasing hormone (1978)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1978-11-10
    Description: In rhesus monkeys with hypothalamic lesions that abolish gonadotropic hormone release by the pituitary gland, the constant infusion of exogenous gonadotropin-releasing hormone (GnRH) fails to restore sustained gonadotropin secretion. In marked contrast, intermittent administration of the synthetic decapeptide once per hour, the physiological frequency of gonadotropin release in the monkeys, reestablishes pituitary gonadotropin secretion. This phenomenon is attributable to the pattern of GnRH delivery rather than to the amounts of this hormone to which the cells of the pituitary are exposed. Moreover, the initiation of continuous GnRH administration in animals with lesions and in which gonadotropin secretion is reestablished by intermittent GnRH replacement can result in a "desensitization" or "down regulation" of the processes responsible for gonadotropin release.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Belchetz, P E -- Plant, T M -- Nakai, Y -- Keogh, E J -- Knobil, E -- New York, N.Y. -- Science. 1978 Nov 10;202(4368):631-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/100883" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Castration ; Dose-Response Relationship, Drug ; Drug Administration Schedule ; Female ; Follicle Stimulating Hormone/*secretion ; Gonadotropin-Releasing Hormone/administration & dosage/*pharmacology ; Haplorhini ; Luteinizing Hormone/*secretion ; Macaca mulatta ; Pituitary Gland, Anterior/*drug effects/secretion
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    alpha1-Antitrypsin: the presence of excess mannose in the Z variant isolated from liver (1978)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1978-09-29
    Description: The Z variant of alpha1-antitrypsin was isolated by a new technique from the liver of a patient homozygous for the Z allele of the protease inhibitor locus. The material was homogenous and antigenically competent but had no protease inhibiting capacity. An interesting correlation was found between the subcellular localization and the carbohydrate composition of the Z variant from liver. Carbohydate analysis of this glycoprotein showed an absence of galactose and sialic acid, an appreciable decrease in N-acetylglucosamine, and an almost twofold increase in mannose residues. These data indicate a considerable slowdown in the processing of the oligosaccharides of liver Z variant. In spite of the absence of sialyl residues, the liver Z varant was microheterogeneous by analytical isoelectric focusing. The isoproteins of liver Z variant coincided with those of asialo M variant in the focusing field.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hercz, A -- Katona, E -- Cutz, E -- Wilson, J R -- Barton, M -- New York, N.Y. -- Science. 1978 Sep 29;201(4362):1229-32.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/308696" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Carbohydrate Metabolism ; Female ; Galactose/metabolism ; Glycoproteins/genetics ; Homozygote ; Humans ; Liver/metabolism ; Mannose/metabolism ; Middle Aged ; Mutation ; Phenotype ; Sialic Acids/metabolism ; alpha 1-Antitrypsin/*genetics/metabolism
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    Risk factor intervention for health maintenance (1978)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1978-05-26
    Description: Risk factors for disease consist of (i) personal habits, such as cigarette smoking and excessive alcohol consumption, and (ii) bodily characteristics, such as hypertension and high serum cholesterol. Progress in identifying and quantifying risk factors is opening the way to the prevention of disease and maintenance of health. Systematic, controlled trials of intervention against risk factors are beginning to produce evidence on the extent of success in reducing both the factors and the mortality from associated diseases.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Breslow, L -- New York, N.Y. -- Science. 1978 May 26;200(4344):908-12.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/644333" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Arteriosclerosis/etiology ; Coronary Disease/etiology/*prevention & control ; Disease/*etiology ; Female ; Humans ; Hypercholesterolemia/complications ; Hypertension/complications ; Lung Neoplasms/etiology ; Male ; Middle Aged ; *Preventive Medicine ; *Probability ; *Risk ; Smoking/complications
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    Transient synapses in the embryonic primate spinal cord (1978)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1978-12-15
    Description: Electron microscopic and tritiated thymidine autoradiographic analysis of the embryonic spinal cord in the rhesus monkey reveals considerable rearrangement of cellular and synaptic relationships in the posterior (sensory) quadrant during early developmental stages. This remodeling involves the death of an entire population of neurons that received synapses from sensory afferent axons and the possible relocation of these afferents upon subsequently generated viable substantia gelatinosa neurons.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Knyihar, E -- Csillik, B -- Rakic, P -- New York, N.Y. -- Science. 1978 Dec 15;202(4373):1206-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/103200" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Axons/ultrastructure ; Cell Survival ; Dendrites/ultrastructure ; Gestational Age ; Haplorhini ; Macaca mulatta ; Spinal Cord/*embryology/ultrastructure ; Synapses/ultrastructure
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    B lymphocyte antigens in sicca syndrome (1978)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1978-03-31
    Description: All individuals tested in this study with sicca syndrome, a human autoimmune disease, bear two immunologically distinct and genetically unrelated B lymphocyte antigens that appear similar to the immune response associated (Ia) antigens of the mouse. The genes coding for these two antigens are present in only 37 and 24 percent of normal controls. In animal models Ia antigen genes are closely linked to immune response genes. Our findings suggest that two such genes may be required for the development of sicca syndrome.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Moutsopoulos, H M -- Chused, T M -- Johnson, A H -- Khudsen, B -- Mann, D L -- New York, N.Y. -- Science. 1978 Mar 31;199(4336):1441-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/415366" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Aged ; Autoimmune Diseases/*immunology ; B-Lymphocytes/*immunology ; Female ; *Genes, MHC Class II ; Genetic Linkage ; HLA Antigens/analysis/genetics ; Humans ; Isoantigens/*analysis/genetics ; Male ; Middle Aged ; Sjogren's Syndrome/genetics/*immunology
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  • 46
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    Lateralization of norepinephrine in human thalamus (1978)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1978-06-23
    Description: Norepinephrine has a strongly lateralized distribution in the human thalamus. In the pulvinar region the left hemisphere is rich in norepinephrine, whereas in the somatosensory input area the right hemisphere has a higher concentration of this catecholamine. Such naturally occurring left-right differences in concentration of a neurotransmitter represent a new aspect of hemispheric specialization.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Oke, A -- Keller, R -- Mefford, I -- Adams, R N -- New York, N.Y. -- Science. 1978 Jun 23;200(4348):1411-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/663623" target="_blank"〉PubMed〈/a〉
    Keywords: Dopamine/metabolism ; *Functional Laterality ; Humans ; Middle Aged ; Norepinephrine/*metabolism ; Somatosensory Cortex/metabolism ; Thalamus/anatomy & histology/*metabolism
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    Memory impairment in epileptic patients: selective effects of phenobarbital concentration (1978)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1978-12-08
    Description: Nineteen epileptic patients were tested first under medium (week 1) and then under high (week 2) therapeutic levels of phenobarbital. Relative to response times of 20 controls with equivalent practice but without medication, response times of patients in a short-term memory scanning task were strikingly slowed during week 2. However, increased phenobarbital did not slow responses in a task requiring access to information in long-term memory.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉MacLeod, C M -- Dekabian, A S -- Hunt, E -- New York, N.Y. -- Science. 1978 Dec 8;202(4372):1102-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/715461" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Dose-Response Relationship, Drug ; Epilepsy/*drug therapy ; Humans ; Memory, Short-Term/*drug effects ; Middle Aged ; Phenobarbital/adverse effects/*pharmacology
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  • 48
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    Neural lateralization of species-specific vocalizations by Japanese macaques (Macaca fuscata) (1978)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1978-10-20
    Description: Five Japanese macaques and five other Old World monkeys were trained to discriminate among field-recorded Japanese macaque vocalizations. One task required discrimination of a communicatively relevant acoustic feature ("peak"), and a second required discrimination of an orthogonal feature of the same vocalizations ("pitch"). The Japanese animals more proficiently discriminated the peak feature when stimuli were presented to the right ear (primarily left cerebral hemisphere), as opposed to the left ear (primarily right hemisphere). In discriminating the pitch feature, the Japanese animals either showed (i) a left-ear processing advantage or (ii) no ear advantage. The comparison animals, with one exception, showed no ear advantage in processing either feature of the vocalizations. The results suggest that Japanese macaques engage left-hemisphere processors for the analysis of communicatively significant sounds that are analogous to the lateralized mechanisms used by humans listening to speech.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Petersen, M R -- Beecher, M D -- Zoloth, S R -- Moody, D B -- Stebbins, W C -- New York, N.Y. -- Science. 1978 Oct 20;202(4365):324-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/99817" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Auditory Perception/*physiology ; Discrimination Learning/physiology ; Female ; *Functional Laterality ; Haplorhini ; Macaca/*physiology ; Male ; Species Specificity ; Vocalization, Animal/*physiology
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    Potency in male rhesus monkeys: effects of continuously receptive females (1978)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1978-04-28
    Description: Ejaculations decreased and mount latencies increased when intact males were paired regularly over a 3.5-year period (3180 tests) with ovariectomized females made constantly receptive by daily injections of estradiol. The deterioration in potency was abruptly and completely reversed by substituting a group of new but similarly treated females for the original ones.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Michael, R P -- Zumpe, D -- New York, N.Y. -- Science. 1978 Apr 28;200(4340):451-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/417398" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Ejaculation ; Female ; Haplorhini ; Macaca/*physiology ; Macaca mulatta/*physiology ; Male ; Pair Bond ; Periodicity ; Seasons ; Sexual Behavior, Animal/*physiology ; Testosterone/blood ; Time Factors
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    delta9-tetrahydrocannabinol: antiaggressive effects in mice, rats, and squirrel monkeys (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-03-31
    Description: delta9-Tetrahydrocannabinol, the most active constituent of marihuana, decreased species-specific attack behavior in mice, rats, and squirrel monkeys at doses (0.25 to 2.0 milligram per kilogram of body weight) that have no effects on other elements of the behavioral repertoire. Aggressive behavior was engendered in all three species by confronting a resident animal with an intruder conspecific. The present results contrast with the widely held belief that marihuana increases aggressive behavior.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Miczek, K A -- New York, N.Y. -- Science. 1978 Mar 31;199(4336):1459-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/415367" target="_blank"〉PubMed〈/a〉
    Keywords: Aggression/*drug effects ; Animals ; Behavior, Animal/*drug effects ; Depression, Chemical ; Dose-Response Relationship, Drug ; Dronabinol/*pharmacology ; Female ; Haplorhini ; Humans ; Male ; Mice ; Motor Activity/drug effects ; Rats ; Saimiri ; Territoriality
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    Dyskinesias evoked in monkeys by weekly administration of haloperidol (1978)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1978-05-19
    Description: In two cebus (Cebus albifrons) monkeys given weekly oral doses of 0.25 milligram of haloperidol per kilogram, movement disorders appeared 1 to 8 hours after drug administration following the tenth weekly dose. These disorders included oral movements, peculiar postures, writhing, and stretching. Such reactions faded in intensity after the next two doses. Increasing the dose to 0.5 milligram per kilogram has elicited the disorders reliably after each weekly dose for almost 2 years. Similar reactions also developed in a squirrel monkey (Saimiri sciurea) treated weekly with haloperidol and in a third cebus monkey previously maintained for a year on a regimen of 0.25 milligram of haloperidol per kilogram on 5 days per week. These findings suggest an experimental model for determining the etiology of drug-induced movement disorders. They also suggest an unrecognized clinical problem.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Weiss, B -- Santelli, S -- New York, N.Y. -- Science. 1978 May 19;200(4343):799-801.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/417399" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Disease Models, Animal ; Dyskinesia, Drug-Induced/*etiology ; *Haloperidol/administration & dosage ; Haplorhini ; Time Factors
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    Cohort mortality for prostatic cancer among United States nonwhites (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-06-09
    Description: In recent decades, age-adjusted mortality rates from prostatic cancer have risen precipitously among blacks, remaining unchanged among whites. It is now the most common cancer among United States black males. When nonwhite mortality rates were examined by age and birth cohort, it was found that peak rates occurred at every age in the cohort of 1896 to 1900, and declined thereafter. This presages an arrest and reversal of the time trend in summary mortality rates as more recent nonwhite cohorts reach the ages of maximum risk.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ernster, V L -- Selvin, S -- Winkelstein, W Jr -- New York, N.Y. -- Science. 1978 Jun 9;200(4346):1165-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/653361" target="_blank"〉PubMed〈/a〉
    Keywords: *African Continental Ancestry Group ; Age Factors ; Aged ; European Continental Ancestry Group ; Humans ; Male ; Middle Aged ; Prostatic Neoplasms/*mortality
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    Cancer death risk in hospitalized mental patients (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-09-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fox, B H -- New York, N.Y. -- Science. 1978 Sep 15;201(4360):966-968.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/684429" target="_blank"〉PubMed〈/a〉
    Keywords: Aged ; Female ; Hospitalization ; Humans ; Male ; Mental Disorders/*complications ; Middle Aged ; Neoplasms/*mortality ; Risk ; United States
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  • 54
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    Immunoreactive vasopressin and oxytocin: concentration in individual human hypothalamic nuclei (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-04-21
    Description: Individual hypothalamic nuclei were microdissected from brain tissue of ten human subjects who had died suddenly while in apparent good health. Appreciable amounts of vasopressin and oxytocin immunoreactivity were found by specific radioimmunoassay in six hypothalamic nuclei including supraoptic and paraventricular nuclei. Vasopressin and oxytocin are presumed to be synthesized in supraoptic and paraventricular nuclei for axonal transport to the posterior pituitary for storage and release. Vasopressin and oxytocin in other hypothalamic nuclei may be a part of this system of neurosecretion or may serve some other function.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉George, J M -- New York, N.Y. -- Science. 1978 Apr 21;200(4339):342-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/556308" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Brain Chemistry ; Female ; Humans ; Hypothalamus/*analysis ; Male ; Median Eminence/analysis ; Middle Aged ; Oxytocin/*analysis ; Paraventricular Hypothalamic Nucleus/analysis ; Radioimmunoassay ; Supraoptic Nucleus/analysis ; Vasopressins/*analysis
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    Age affect and replicative life-span of fibroblasts of diabetic, prediabetic, and normal donors: another look at the data (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-12-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gleason, R E -- Goldstein, S -- New York, N.Y. -- Science. 1978 Dec 15;202(4373):1217-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/725599" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Aged ; *Aging ; Cell Division ; Cell Survival ; Cells, Cultured ; Diabetes Mellitus/*physiopathology ; Humans ; Middle Aged ; Prediabetic State/*physiopathology
    Print ISSN: 0036-8075
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  • 56
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    Anosmia in male rhesus monkeys does not alter copulatory activity with cycling females (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-03-10
    Description: Three adult male rhesus monkeys were tested daily with intact adult female partners over the course of four or five mentstrual cycles. The males were made permanently anosmic by chemical ablation of the olfactory epithelium after the second or fourth cycle was completed. All males continued to display typical cycles of copulation with their partners after the anosmia procedures, with the shortest latencies to ejaculation occurring during the periovulatory phase of the partner's ovulatory cycle. Hence, female attractivity and cyclic copulatory performance of rhesus monkeys are not dependent upon olfactory signals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goldfoot, D A -- Essock-Vitale, S M -- Asa, C S -- Thornton, J E -- Leshner, A I -- New York, N.Y. -- Science. 1978 Mar 10;199(4333):1095-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/415362" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Copulation/*physiology ; Female ; Haplorhini ; Macaca/*physiology ; Macaca mulatta/*physiology ; Male ; Menstruation ; *Odors ; Olfaction Disorders ; Vasectomy
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  • 57
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    Chronologic and physiologic age affect replicative life-span of fibroblasts from diabetic, prediabetic, and normal donors (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-02-17
    Description: Cultured skin fibroblasts from subjects with clinically apparent diabetes mellitus and from subjects genetically predisposed to diabetes have a replicative lifespan that is inversely related to donor age. Fibroblasts from carefully defined normal subjects not predisposed to diabetes fail to show this correlation. The data support the idea that physiologic status of the tissue donor is a more precise determinant of fibroblast replicative lifespan than chronologic age.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goldstein, S -- Moerman, E J -- Soeldner, J S -- Gleason, R E -- Barnett, D M -- New York, N.Y. -- Science. 1978 Feb 17;199(4330):781-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/622567" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Aged ; *Aging ; Cell Division ; Cell Survival ; Cells, Cultured ; Diabetes Mellitus/pathology/*physiopathology ; Fibroblasts/*cytology/pathology ; Humans ; Middle Aged ; Prediabetic State/pathology/*physiopathology ; Regression Analysis ; Skin/cytology/pathology
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    Macroeconomics of disease prevention in the United States (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-06-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gori, G B -- Richter, B J -- New York, N.Y. -- Science. 1978 Jun 9;200(4346):1124-30.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/653358" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Age Factors ; Aged ; Child ; Child, Preschool ; Costs and Cost Analysis ; Environment ; Female ; Government ; Humans ; Infant ; Life Expectancy ; Male ; Middle Aged ; Population Dynamics ; *Preventive Medicine ; Social Security ; Socioeconomic Factors ; United States
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  • 59
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    Melatonin content of the human pineal gland (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-01-06
    Description: Gas chromatography with electron capture detection was used to quantitate melatonin in single human pineal glands. The sensitivity of this melatonin assay is in the low picogram range. A 24-hour rhythm of pineal melatonin content was observed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Greiner, A C -- Chan, S C -- New York, N.Y. -- Science. 1978 Jan 6;199(4324):83-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉North Lawn Unit, Riverview Hospital, Essondale, British Columbia, Canada.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17569491" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Aged ; Aged, 80 and over ; Chromatography, Gas ; Female ; Gas Chromatography-Mass Spectrometry ; Humans ; Male ; Melatonin/analogs & derivatives/*analysis ; Middle Aged ; Pineal Gland/*chemistry
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    Vasectomy increases the severity of diet-induced atherosclerosis in Macaca fascicularis (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-08-11
    Description: Diet-induced atherosclerosis developed more extensively in vasectomized cynomolgus monkeys (Macaca fascicularis) than in sham-vasectomized control monkeys fed the same diet. The effect was most pronounced in the abdominal aortas, carotid arteries, distal segments of the coronary arteries, and intracranial cerebral arteries. Antibodies to sperm developed in all vasectomized monkeys, and complement and immunoglobulins were associated with atherosclerotic plaques in some of the vasectomized animals. The immunological response to sperm antigens that often accompanies vasectomy may exacerbate atherosclerosis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Alexander, N J -- Clarkson, T B -- New York, N.Y. -- Science. 1978 Aug 11;201(4355):538-41.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/96532" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arteries/immunology/pathology ; Arteriosclerosis/*etiology/immunology/pathology ; Autoantibodies ; Cholesterol/metabolism ; Cholesterol Esters/metabolism ; Diet, Atherogenic ; Haplorhini ; Macaca fascicularis ; Male ; Spermatozoa/immunology ; Vasectomy/*adverse effects
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    Choice behavior in rhesus monkeys: cocaine versus food (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-08-11
    Description: Rhesus monkeys were allowed to choose between intravenous injections of cocaine and food reinforcement for lever pressing. A choice trial was available every 15 minutes continuously for 8 days. The animals chose cocaine almost exclusively, which resulted in high cocaine intake, decreased food intake, weight loss, and marked behavioral toxicity. The study provides evidence of the reinforcing efficacy of cocaine.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Aigner, T G -- Balster, R L -- New York, N.Y. -- Science. 1978 Aug 11;201(4355):534-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/96531" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal/drug effects ; Body Weight ; Choice Behavior/*drug effects ; Cocaine/*pharmacology ; Decision Making/*drug effects ; Feeding Behavior/*drug effects ; Haplorhini ; Macaca mulatta ; Male ; Posture ; *Reinforcement (Psychology)
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    Primate infant's effects on mother's future reproduction (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-09-15
    Description: Female savanna baboons (Papio cynocephalus) had a longer postpartum amenorrhea and thereafter cycled longer before conceiving if their previous infant survived than if that infant died. Among mothers of surviving infants, differences in maternal care produced differences in age of weaning and age of independence but did not result in differences in interbirth intervals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Altmann, J -- Altmann, S A -- Hausfater, G -- New York, N.Y. -- Science. 1978 Sep 15;201(4360):1028-30.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/98844" target="_blank"〉PubMed〈/a〉
    Keywords: Amenorrhea ; Animals ; Female ; Haplorhini ; Maternal Behavior ; Papio/*physiology ; *Postpartum Period ; Pregnancy ; *Reproduction ; Time Factors ; Weaning
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  • 63
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    Copulatory vocalizations of chacma baboons (Papio ursinus), gibbons (Hylobates hoolock), and humans (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-06-23
    Description: The copulatory vocalizations of female baboons (Papio ursinus) are more complex than those of female gibbons (Hylobates hoolock) or human females. Adult males of all these species begin calling later than the female, but subordinate baboon males do not call. Copulatory vocalizations may serve to mutually stimulate the mating partners or to incite male competition.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hamilton, W J 3rd -- Arrowood, P C -- New York, N.Y. -- Science. 1978 Jun 23;200(4348):1405-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/663622" target="_blank"〉PubMed〈/a〉
    Keywords: Age Factors ; Animals ; Female ; Hominidae/*physiology ; Humans ; Hylobates/*physiology ; Male ; Middle Aged ; Papio/*physiology ; Respiration ; Sexual Behavior/*physiology ; Sexual Behavior, Animal/*physiology ; Vocalization, Animal/*physiology
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    Lichen myxedematosus serum stimulates human skin fibroblast proliferation (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-02-03
    Description: Serum from patients with lichen myxedematosus, when added to exponentially growing normal human skin fibroblasts, stimulates DNA synthesis and cell proliferation. The degree of response in vitro is correlated with the extent of the disease in vivo and is specific for fibroblasts. The results suggest that there is a systemic factor (or factors) which may play a role in the etiology of diseases affecting the connective tissue.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Harper, R A -- Rispler, J -- New York, N.Y. -- Science. 1978 Feb 3;199(4328):545-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/622555" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Division ; Cells, Cultured ; Female ; Fibroblasts/metabolism ; Humans ; Immunoglobulin G/analysis ; Male ; Middle Aged ; Skin Diseases/*blood/immunology/pathology ; Thymidine/metabolism
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    Mummy of the "Elder Lady" in the tomb of Amenhotep II: Egyptian museum catalog number 61070 (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-06-09
    Description: An unidentified female mummy found in a cache of great kings and queens in 1898 in the Valley of the Kings was examined from the viewpoint of Egyptology, x-ray cephalometry, biostatistics, and biochemistry. The result was the identification of Queen Tiye, of the Eighteenth Dynasty, wife of Amenhotep III and mother of Akhenaton.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Harris, J E -- Wente, E F -- Cox, C F -- Nawaway, I E -- Kowalski, C J -- Storey, A T -- Russell, W R -- Ponitz, P V -- Walker, G F -- New York, N.Y. -- Science. 1978 Jun 9;200(4346):1149-51.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/349693" target="_blank"〉PubMed〈/a〉
    Keywords: Cephalometry ; Egypt ; Electron Probe Microanalysis ; Female ; Hair/analysis ; History, Ancient ; Humans ; Middle Aged ; *Mummies ; Skull/radiography
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    Primate neurobiology: neurosurgery with fetuses (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-03-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G B -- New York, N.Y. -- Science. 1978 Mar 3;199(4332):960-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/414357" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/embryology/surgery ; Eye/embryology/innervation ; Fetus/*surgery ; Haplorhini ; Nervous System/*embryology ; Neural Pathways/embryology ; *Neurosurgery ; Neurosurgical Procedures ; Primates/*embryology/surgery ; Research ; Visual Cortex/embryology/surgery
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    Immunization against infectious disease (1978)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1978-05-26
    Description: Mortality and morbidity from infectious diseases in the United States have declined more than 90 percent since 1900. Factors believed to be responsible for this decline include changes in the natural history of disease, sanitation, quarantine measures, control of nonhuman vectors, antibacterial drugs, and immunization. The contributions of each of these factors differ among the various infectious diseases; except for smallpox and diphtheria control, immunization had little effect until after World War II. The success of present and future immunization programs is endangered by public and physician complacency and by complex legal and ethical problems related to informed consent and responsibility for rare, vaccine-related injury.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mortimer, E A Jr -- New York, N.Y. -- Science. 1978 May 26;200(4344):902-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/347579" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Aged ; Child ; Child, Preschool ; *Communicable Disease Control ; Communicable Diseases/history/mortality ; History, 20th Century ; Humans ; *Immunization/adverse effects/history ; Infant ; Middle Aged ; United States ; Vaccination/history ; Vaccines/adverse effects ; Vaccines, Attenuated/adverse effects
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    Processes controlling arm movements in monkeys (1978)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1978-09-29
    Description: The experiments identify some of the processes underlying arm movements in rhesus monkeys. Three monkeys were trained to point to a target with the hand and forearm and to hold that position for about 1 second to obtain a reward. Forearm movements were performed without sight of the arm before and after bilateral dorsal rhizotomy. In both intact and deafferented animals, we unexpectedly displaced the forearm prior to movement initiation and observed that the arm moved accurately to the target. These results are relevant to the question of what is being controlled by motor commands. The controlled variable appears to be an equilibrium point between agonist and antagonist muscles. The findings suggest that the feedback system plays a major role in updating and adjusting the central programs subserving the execution of learned motor patterns.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Polit, A -- Bizzi, E -- New York, N.Y. -- Science. 1978 Sep 29;201(4362):1235-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/99813" target="_blank"〉PubMed〈/a〉
    Keywords: Afferent Pathways/physiology ; Animals ; Arm/*physiology ; Feedback ; Haplorhini ; Macaca mulatta ; *Movement ; *Proprioception ; Visual Perception/physiology
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    Measurement of regional substrate utilization rates by emission tomography (1978)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1978-03-03
    Description: Emission tomography can be used to monitor, in vivo and regionally, the utilization of metabolic substrates labeled with positron-emitting radioisotopes produced by a cyclotron. The concept was validated by measuring brain glucose utilization with carbon--11-labeled glucose in rhesus monkeys.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Raichle, M E -- Welch, M J -- Grubb, R L Jr -- Higgins, C S -- Ter-Pogossian, M M -- Larson, K B -- New York, N.Y. -- Science. 1978 Mar 3;199(4332):986-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/414358" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/*metabolism/radionuclide imaging ; Carbon Radioisotopes ; Glucose/*metabolism ; Haplorhini ; Macaca mulatta ; Tomography/*utilization ; Tomography, X-Ray Computed/utilization
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    Age determination of an Alaskan mummy: morphological and biochemical correlation (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-09-01
    Description: Aspartic acid racemization analysis of a tooth from an Alaskan mummy yielded an age at death of 53 (+/- 5) years, which correlates well with earlier estimates based on morphological features. This study illustrates the value of integrative approaches to paleopathologic problems and the importance of preserving rare specimens for the application of new techniques.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Masters, P M -- Zimmerman, M R -- New York, N.Y. -- Science. 1978 Sep 1;201(4358):811-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/356264" target="_blank"〉PubMed〈/a〉
    Keywords: *Aspartic Acid ; Bicuspid ; Female ; History, Ancient ; Humans ; Middle Aged ; Mummies ; *Paleodontology ; Stereoisomerism
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 71
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    Highly reiterated sequences of SIMIANSIMIANSIMIANSIMIANSIMIAN (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-04-28
    Description: A 172-base pair segment of DNA that is repeated several million times in the genome of the African green monkey has been characterized. Sequence analysis revealed that the many repeats of this complex unit are not all identical but represent a set of closely related segments: Sequence divergence occurs at various positions in the segment in a nonrandom manner. The uncloned segment obtained from monkey DNA is compared with a cloned segment of the same DNA which was recombined into the genome of simian virus 40 during permissive infection.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rosenberg, H -- Singer, M -- Rosenberg, M -- New York, N.Y. -- Science. 1978 Apr 28;200(4340):394-402.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/205944" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Biological Evolution ; Cell Line ; Cercopithecus/*genetics ; Cercopithecus aethiops/*genetics ; DNA/*genetics ; DNA Restriction Enzymes ; DNA, Recombinant ; Haplorhini ; Molecular Weight ; Recombination, Genetic ; Simian virus 40/genetics
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 72
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    Adherence of group A streptococci to pharyngeal cells: a role in the pathogenesis of rheumatic fever (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-08-04
    Description: We used an assay in vitro to investigate the possible role of streptococcal adherence to human pharyngeal cells in the pathogenesis of acute rheumatic fever. There was no difference in adherence of rheumatic fever-associated and non-associated strains of group A streptococci to pooled pharyngeal cells of normal people. Likewise, streptococci not associated with rheumatic fever adhered equally well to cells taken from normal people and from patients with rheumatic heart disease. However, the pharyngeal cells of all nine rheumatic heart disease patients tested had increased avidity for adherence for a rheumatic fever-associated strain of streptococcus compared to the pharyngeal cells obtained from age- and sex-matched controls. Increased streptococcal adherence to pharyngeal cells of rheumatic fever-prone patients may play a role in the pathogenesis of rheumatic fever.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Selinger, D S -- Julie, N -- Reed, W P -- Williams, R C Jr -- New York, N.Y. -- Science. 1978 Aug 4;201(4354):455-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/351810" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Female ; Humans ; Male ; Middle Aged ; Pharyngeal Diseases/complications/microbiology ; Pharynx/*microbiology ; Rheumatic Fever/*etiology/microbiology ; Streptococcus pyogenes/*physiology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 73
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    Spinothalamic tract neurons in the substantia gelatinosa (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-12-01
    Description: The substantia gelatinosa of the mammalian spinal cord is generally believed to be a closed system; that is its neurons are thought to project only to the substantia gelatinosa of the same or the contralateral side. Experiments in monkeys, using injections of the marker enzyme horseradish peroxidase, show that at least some neurons of the substantia gelatinosa project to the thalamus and thus belong to the spinothalamic tract. Such neurons include two cell types intrinsic to the gelatinosa, the central cells and the limitrophe cells of Cajal.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Willis, W D -- Leonard, R B -- Kenshalo, D R Jr -- New York, N.Y. -- Science. 1978 Dec 1;202(4371):986-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/102034" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Diencephalon/*cytology ; Haplorhini ; Macaca fascicularis ; Spinal Cord/*cytology ; Spinothalamic Tracts/*cytology ; Substantia Gelatinosa/*cytology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 74
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    Acute myelogenous leukemia: a human cell line responsive to colony-stimulating activity (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-06-09
    Description: A permanent human cell line that maintains the granulocytic characteristics of acute myelogenous leukemia cells has been established. The cells of this line form myeloid colonies in soft gel culture in the presence of human colony-stimulating activity. The cell line may be useful for studying human acute myelogenous leukemia and the mechanism of response to colony-stimulating activity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Koeffler, H P -- Golde, D W -- New York, N.Y. -- Science. 1978 Jun 9;200(4346):1153-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/306682" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Division/drug effects ; *Cell Line ; Chromosome Aberrations/genetics ; Chromosome Disorders ; Colony-Stimulating Factors/*pharmacology ; Glycoproteins/*pharmacology ; Granulocytes/pathology ; Humans ; Leukemia, Myeloid, Acute/genetics/*pathology ; Male ; Middle Aged ; Receptors, Antigen, B-Cell/analysis
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 75
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    Ultradian cortisol rhythms in monkeys: synchronized or not synchronized? (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-12-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kronauer, R E -- Moore-Ede, M C -- Menser, M S -- New York, N.Y. -- Science. 1978 Dec 1;202(4371):1001-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/102033" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Haplorhini ; Hydrocortisone/*blood ; Light ; Macaca mulatta/blood ; *Periodicity
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 76
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    Central nervous system dysfunction due to lead exposure (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-08-04
    Description: Central nervous system dysfunction was investigated in workers at a secondary lead smelter by means of performance tests. Correlations between test scores and zinc protoporphyrin levels, a biological indicator of lead toxicity, are statistically significant. This correlation should prove to be useful in current efforts to evaluate effects of lead exposure.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Valciukas, J A -- Lilis, R -- Fischbein, A -- Selikoff, I J -- Eisinger, J -- Blumberg, W E -- New York, N.Y. -- Science. 1978 Aug 4;201(4354):465-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/663669" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Aged ; Behavior/physiology ; Central Nervous System/*physiopathology ; Environmental Exposure ; Humans ; Lead/blood ; Lead Poisoning/blood/*physiopathology ; Middle Aged ; Neurologic Examination/methods ; Occupational Diseases/*physiopathology ; Porphyrins/*blood ; Protoporphyrins/*blood ; Zinc/blood
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 77
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    Localization of primate calls by old world monkeys (1978)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1978-08-25
    Description: Monkeys (Macaca) were trained by operant conditioning techniques to report the minimum detectable change in location of a sound in space, and were tested with a series of recorded coo or clear call vocalizations. Acuity of localization varied from approximately 4 degrees to 15 degrees and was a function of the magnitude of the change in pitch (frequency modulation) of the different clear calls.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brown, C H -- Beecher, M D -- Moody, D B -- Stebbins, W C -- New York, N.Y. -- Science. 1978 Aug 25;201(4357):753-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/97785" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Auditory Perception/*physiology ; Haplorhini ; Macaca/*physiology ; Orientation/*physiology ; Pitch Discrimination/physiology ; Vocalization, Animal/*physiology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 78
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    Eye movements of monkeys during learning-set formation (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-03-24
    Description: Eye movements of stump-tailed monkeys were measured during learning of a long series of two-choice pattern discrimination problems. The amount of scanning per trial (shifts in visual fixation from one pattern to the other) and the duration of individual fixations on the patterns increased during the course of learning-set formation and (except for the amount of scanning by some animals) remained high during the prolonged training following learning-set formation. Some of the changes in eye movements were different from those seen during the learning of single discrimination problems, a difference that possibly reflects cognitive processes specific to the learning-set task.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schrier, A M -- Povar, M L -- New York, N.Y. -- Science. 1978 Mar 24;199(4335):1362-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/415365" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Discrimination Learning/*physiology ; *Eye Movements ; Haplorhini ; Macaca ; Time Factors
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Vaccination of experimental monkeys against Plasmodium falciparum: a possible safe adjuvant (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-09-29
    Description: Owl monkeys (Aotus trivirgatus griseimembra) were effectively immunized against a human malaria parasite, Plasmodium falciparum. Two injections of antigen, primarily mature segmenters with fully developed merozoites, mixed with adjuvant (6-O-stearoyl-N-acetylmuramyl-L-alanyl-D-isoglutamine and liposomes) were administered intramuscularly at a 4-week interval. Approximately 2 weeks after the second vaccination, the monkeys were challenged with the homologous strain of P. falciparum. All immunized monkeys survived the challenge. The substitution of Freund's complete adjuvant is an encouraging step toward the development of an effective and safe vaccine for human malaria.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Siddiqui, W A -- Taylor, D W -- Kan, S C -- Kramer, K -- Richmond-Crum, S M -- Kotani, S -- Shiba, T -- Kusumoto, S -- New York, N.Y. -- Science. 1978 Sep 29;201(4362):1237-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/99814" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylmuramyl-Alanyl-Isoglutamine/*immunology ; *Adjuvants, Immunologic ; Animals ; Glycopeptides/*immunology ; Haplorhini ; Liposomes ; Malaria/*prevention & control ; Plasmodium falciparum/*immunology ; *Vaccination
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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