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  • 1
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    X-linked inhibitor of apoptosis protein mediates tumor cell resistance to antibody-dependent cellular cytotoxicity (2016)
    Springer Nature
    Details
    Publication Date: 2016-01-29
    Description: X-linked inhibitor of apoptosis protein mediates tumor cell resistance to antibody-dependent cellular cytotoxicity Cell Death and Disease 7, e2073 (January 2016). doi:10.1038/cddis.2015.412 Authors: M K Evans, S J Sauer, S Nath, T J Robinson, M A Morse & G R Devi
    Electronic ISSN: 2041-4889
    Topics: Biology , Medicine
    Published by Springer Nature
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  • 2
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    Discovery of insect and human dengue virus host factors (2009)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2009-04-28
    Description: Dengue fever is the most frequent arthropod-borne viral disease of humans, with almost half of the world's population at risk of infection. The high prevalence, lack of an effective vaccine, and absence of specific treatment conspire to make dengue fever a global public health threat. Given their compact genomes, dengue viruses (DENV-1-4) and other flaviviruses probably require an extensive number of host factors; however, only a limited number of human, and an even smaller number of insect host factors, have been identified. Here we identify insect host factors required for DENV-2 propagation, by carrying out a genome-wide RNA interference screen in Drosophila melanogaster cells using a well-established 22,632 double-stranded RNA library. This screen identified 116 candidate dengue virus host factors (DVHFs). Although some were previously associated with flaviviruses (for example, V-ATPases and alpha-glucosidases), most of the DVHFs were newly implicated in dengue virus propagation. The dipteran DVHFs had 82 readily recognizable human homologues and, using a targeted short-interfering-RNA screen, we showed that 42 of these are human DVHFs. This indicates notable conservation of required factors between dipteran and human hosts. This work suggests new approaches to control infection in the insect vector and the mammalian host.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3462662/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3462662/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sessions, October M -- Barrows, Nicholas J -- Souza-Neto, Jayme A -- Robinson, Timothy J -- Hershey, Christine L -- Rodgers, Mary A -- Ramirez, Jose L -- Dimopoulos, George -- Yang, Priscilla L -- Pearson, James L -- Garcia-Blanco, Mariano A -- 1R01AI061576-01/AI/NIAID NIH HHS/ -- 1R01AI076442/AI/NIAID NIH HHS/ -- 1SA0RR024572-1/RR/NCRR NIH HHS/ -- 5P30-CA14236/CA/NCI NIH HHS/ -- 5U54-AI057157-05S/AI/NIAID NIH HHS/ -- R01 AI076442/AI/NIAID NIH HHS/ -- R01 AI078997/AI/NIAID NIH HHS/ -- R01 AI078997-01A1/AI/NIAID NIH HHS/ -- R01 AI078997-02/AI/NIAID NIH HHS/ -- R01 GM067761/GM/NIGMS NIH HHS/ -- R21 AI090188/AI/NIAID NIH HHS/ -- R21 AI090188-01/AI/NIAID NIH HHS/ -- R21 NS063845/NS/NINDS NIH HHS/ -- R21-AI64925/AI/NIAID NIH HHS/ -- T32 AI007417/AI/NIAID NIH HHS/ -- U54 AI057157/AI/NIAID NIH HHS/ -- U54 AI057159/AI/NIAID NIH HHS/ -- England -- Nature. 2009 Apr 23;458(7241):1047-50. doi: 10.1038/nature07967.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19396146" target="_blank"〉PubMed〈/a〉
    Keywords: Aedes/genetics/virology ; Animals ; Cell Line ; Conserved Sequence/*genetics/physiology ; Dengue Virus/*physiology ; Drosophila melanogaster/*genetics/physiology/*virology ; Gene Knockdown Techniques ; Genome, Insect/genetics ; Host-Pathogen Interactions/*genetics ; Humans ; Insect Vectors/*genetics/*physiology ; RNA Interference ; RNA, Double-Stranded/genetics/metabolism ; Virus Replication
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 3
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    Impacts of the Cretaceous Terrestrial Revolution and KPg extinction on mammal diversification (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-09-24
    Description: Previous analyses of relations, divergence times, and diversification patterns among extant mammalian families have relied on supertree methods and local molecular clocks. We constructed a molecular supermatrix for mammalian families and analyzed these data with likelihood-based methods and relaxed molecular clocks. Phylogenetic analyses resulted in a robust phylogeny with better resolution than phylogenies from supertree methods. Relaxed clock analyses support the long-fuse model of diversification and highlight the importance of including multiple fossil calibrations that are spread across the tree. Molecular time trees and diversification analyses suggest important roles for the Cretaceous Terrestrial Revolution and Cretaceous-Paleogene (KPg) mass extinction in opening up ecospace that promoted interordinal and intraordinal diversification, respectively. By contrast, diversification analyses provide no support for the hypothesis concerning the delayed rise of present-day mammals during the Eocene Period.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Meredith, Robert W -- Janecka, Jan E -- Gatesy, John -- Ryder, Oliver A -- Fisher, Colleen A -- Teeling, Emma C -- Goodbla, Alisha -- Eizirik, Eduardo -- Simao, Taiz L L -- Stadler, Tanja -- Rabosky, Daniel L -- Honeycutt, Rodney L -- Flynn, John J -- Ingram, Colleen M -- Steiner, Cynthia -- Williams, Tiffani L -- Robinson, Terence J -- Burk-Herrick, Angela -- Westerman, Michael -- Ayoub, Nadia A -- Springer, Mark S -- Murphy, William J -- New York, N.Y. -- Science. 2011 Oct 28;334(6055):521-4. doi: 10.1126/science.1211028. Epub 2011 Sep 22.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, University of California, Riverside, CA 92521, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21940861" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Evolution ; Evolution, Molecular ; *Extinction, Biological ; *Fossils ; *Mammals/classification/genetics ; Molecular Sequence Data ; *Phylogeny
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Erythrocytes: a new cell type for the evaluation of insulin receptor defects in diabetic humans (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-07-13
    Description: Human erythrocytes have specific insulin receptors. When studied in an insulin radioreceptor assay, erythrocytes from adult-onset, nonobese diabetic subjects bound at least 42 percent less insulin than the normal subjects at insulin concentrations from 0.1 to 100 nanograms per milliliter. The diabetic subjects had 190 insulin receptor sites per cell as compared with the 380 insulin receptor sites per cell for the normal subjects. The deficit of insulin binding in the diabetic subject was thus associated with a fewer number of insulin binding sites per cell with little or no change in affinity. The erythrocyte is a readily available cell for the evaluation of cellular insulin receptor activity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Robinson, T J -- Archer, J A -- Gambhir, K K -- Hollis, V W Jr -- Carter, L -- Bradley, C -- New York, N.Y. -- Science. 1979 Jul 13;205(4402):200-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451590" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Aged ; Diabetes Mellitus/*blood/metabolism ; Erythrocyte Membrane/*metabolism ; Erythrocytes/*metabolism ; Female ; Humans ; Insulin/metabolism ; Male ; Middle Aged ; Receptor, Insulin/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
    Electronic Resource
    Electronic Resource
    Role of Progesterone in the Mating Behaviour of the Ewe (1952)
    [s.l.] : Nature Publishing Group
    Nature 170 (1952), S. 373-374 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] During December 1951, at which month ewes of British breed are in deep ancestrus in Australia, experiments were carried out on the Wernbee State Research Farm near Melbourne, with the object of determining the role of progesterone in inducing mating behaviour. In the first trial, four groups, each ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/170373a0
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  • 6
    Electronic Resource
    Electronic Resource
    Relationship of Œstrogen and Progesterone in Œstrous Behaviour of the Ewe (1954)
    [s.l.] : Nature Publishing Group
    Nature 173 (1954), S. 878-878 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] In attempts to elucidate this phenomenon two series of experiments were conducted between June 1952 and December 1953 at the State Research Farm, Werribee. In the first series, twelve ovariectomized Suffolk cross-bred ewes were used in two groups, A and B, of six ewes eac]a" Each group received the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/173878a0
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  • 7
    Electronic Resource
    Electronic Resource
    Œstrus-inducing Activity of Testosterone in the Ewe (1961)
    [s.l.] : Nature Publishing Group
    Nature 192 (1961), S. 761-762 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Table 1. BEHAVIOURAL AND VAGINAL RESPONSE TO TESTOSTERONE PROPIONATE ADMINISTERED TO 72 EWES WITH OR WITHOUT PROGESTERONE PRETREATMENT Dose of testosterone Treated with Not treated propionate progesterone with Tot (mgm.) 1-0 progesterone Behavioural 6 4 10 response 3-2 10 11 21 ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/192761a0
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  • 8
    Electronic Resource
    Electronic Resource
    Mitochondrial DNA Phylogeography and Comparative Cytogenetics of the Springhare, Pedetes capensis (Mammalia: Rodentia) (1997)
    Springer
    Journal of mammalian evolution 4 (1997), S. 53-73 
    Details
    ISSN: 1573-7055
    Keywords: springhare ; rodent ; mtDNA population structure ; chromosomes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Variation in mitochondrial DNA (mtDNA) was used together with comparative cytogenetics to examine the evolutionary history and taxonomic status of an African hystricomorphous rodent, the springhare Pedetes capensis. The mtDNA phylogeographic structure showed that the majority of the southern African populations (P. c. capensis) are characterized by unique but closely related maternal lineages. Based on restriction endonuclease fragment analysis, the east African populations (P. c. surdaster) appear more structured and are distinguished from those in southern Africa by an average sequence divergence of 5.52% (±1.4%). This marked divergence is concordant with results of the cytogenetic study. Specimens from southern Africa have 2n = 38, and those from east Africa 2n = 40. The change in diploid number is due to a single centric fusion. It is suggested that the closure of the Brachystegia or “miombo” woodland (20,000–10,000 B.P.), which delimits contemporary springhare ranges, may have been too recent to account for the accumulated genetic differences that distinguish these taxa. While rifting and associated habitat changes in east Africa can be invoked to explain genetic structure in this region, the southern African springhare populations, which have a high incidence of locality-specific haplotypes, show a shallow phylogeographic structure, in keeping with a relatively recent range expansion from smaller source populations. Given the magnitude of genetic, morphological, and ethological differences between the two geographic isolates, we believe that there is strong support for the elevation of the east African and southern African springhare populations to full species status, thus supporting earlier taxonomic treatments of this rodent.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1027331727034
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  • 9
    Electronic Resource
    Electronic Resource
    Use of Progestagen-Impregnated Sponges Inserted Intravaginally or Subcutaneously for the Control of the Oestrous Cycle in the Sheep (1965)
    [s.l.] : Nature Publishing Group
    Nature 206 (1965), S. 39-41 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SHELTON1,2 has described the identification of two progestagens of high biological activity in the sheep. One (SC-9880, 17a-acetoxy-9a-fluoro-11β-hydroxy-pregn-4-en-3,20-dione) had characteristics indistinguishable from those of progesterone, but was 25 times more active. The other (SC-10363, ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/206039a0
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  • 10
    Electronic Resource
    Electronic Resource
    Multiple common fragile sites are expressed in the genome of the laboratory rat (1987)
    Springer
    Chromosoma 96 (1987), S. 45-49 
    Details
    ISSN: 1432-0886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Splenic lymphocytes from Sprague Dawley and Fischer 344 rats were exposed to two chemicals known to induce common fragile site expression in man: fluorodeoxyuridine (in conjunction with the enhancing effects of caffeine) and aphidicolin. Of 39 sites that were significantly damaged in excess, 12 meet the criteria for fragility proposed in this investigation. Rat fragile sites appear to differ from those in man in that no common hierarchical frequency of expression is evident from the two methods of induction. In addition, a comparison of published cancer-specific chromosome breakpoints from a variety of rat tumors reveals little or no apparent concordance with the identified fragile sites. The rat is an animal model in which multiple common fragile sites can be induced and, as such, will be valuable for testing hypotheses concerning the biological basis of chromosomal fragility.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00285882
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