ALBERT

Notes: Five human teratoma cell lines have been characterized for the presence of a certain number of marker antigens whose presence or absence has been shown to be characteristic of mouse embryonal carcinoma (EC) cells. Four out of the five lines have been shown to respond to at least some of the criteria associated with murine EC cells even though only limited in vitro differentiation could be demonstrated. The significance of certain unusual marker antigen combinations present on the cell line Tera I and its clones and so far unobserved for the murine model is discussed. The observation in Tera I populations of cells carrying simultaneously both the F9 and β2-microglobulin or HLA antigens, suggest that the human cell lines may represent a novel material for the study of mammalian differentiation.

Notes: Principles of Gene Manipulation. Studies in Microbiology

Notes: A healthy 22-year-old woman was noted to have erythrocytes of the Pk phenotype: a strong Pk antigen, no detectable P antigen and anti-P antibody in her serum. Her erythrocytes contained four to six times as much Pk glycolipid (globotriaosylceramide or CTH) and approximately half as much P glycolipid (globotertraosylceramide or globoside) as normal red cells. The structures of CTH and globoside were characterized by analysis of permethylated sugars and complement fixation in addition to chromaographic mobility and sugar composition. Inasmuch as the erythrocytes of two Pk individuals that were analysed previously (Marcus et al., 1976) contained no detectable globoside, these abnormalities appear o represent a new phenotype in the P blood group system.

Notes: We studied 201 unrelated French Basque individuals for HLA and Bf polymorphisms. The haplotypes of eighty-seven of them were deduced from family studies. The results show the frequency of the Bf F1 allele (0.1393) which is the highest one currently reported. They confirm the high frequencies of HLA-Aw19.2 and B18 previously reported in that population and show that a whole haplotype with strong linkage disequilibria, namely Aw19.2, Cw5, B18, Bf F1, DRw3 is frequent. On the other hand, the gene frequency of Bf S is decreased (0.5497) as compared with the other European Caucasoïd populations, while a slight increase in the Bf F gene frequency (0.2960) appears. These results point out that it is of importance to consider the genetic background in choosing the population where linkage disequilibria are to be studied.

Notes: The genetic control of hybrid resistance to BALB/c fibrosarcoma Meth-A was investigated. A Meth-A tumour grew slower in (BALB/c X C57BL/6)F1 and reciprocal hybrid mice than in syngeneic BALB/c mice and was also found to grow slower in females than in males. Significant F1 resistance was demonstrated after both subcutaneous and intraperitoneal injection of tumour cells. However, (BALB/c X DBA/2)F1 mice did not show any significant resistance to Meth-A. In H-2 linkage studies of [BALB/c X (BALB/c X C57BL/6)] backcross mice, no statistically significant differences in the resistance of H-2 heterozygotes and homozygotes to Meth-A were observed. These results indicated that F1 hybrid resistance to Meth-A was controlled by non-H-2-linked resistance factor(s). No linkage was observed between resistance to Meth-A and coat colour c- and b-loci.

Notes: CBA/N mice have an X-linked B cell defect which prevents them from responding to non-mitogenic thymic independent (TI-II) antigens such as dinitrophenylated (DNP-AGG) Ficoll. The F1 male progeny of CBA/N female mice express the same defect. Spleen cell suspensions from such defective mice (CBA/N X C3H/HeN F1 males) could not respond to DNP-AGG-Ficoll following in vitro immunization and subsequent transfer into irradiated, syngeneic, F1 male recipients as expected. In contrast, normal CBA/N X C3H/HeN F1 female spleen cells could respond and effect a ‘rescue'; they mounted strong plaque-foriming cell 7 days after in vitro exposure to DNP-AGG-Ficoll and subsequent transfer into irradiated F1 male recipients. Defective F1 male spleen cells could bind significant quantities of DNP-AGG-Ficoll, however, after, in vitro exposure. Extensive washing of these spleen cells could not reverse this binding. Such DNP-AGG-Ficoll-exposed and washed F1 male spleen cells could, after transfer, aid normal untreated F1 female cells in their rescue function. The defective F1 male spleen cells could convey immunogenic quantities of DNP-AGG-Ficoll to the ‘rescuing’ F1 female cells.Mitomycin treatment of F1 male cells did not interfere with their conveyor function. Goat anti-mouse μ serum impeded the passive antigen conveyor function of defective F1 male cells as did prior exposure to high concentrations of free DNP-AGG hapten. Our data support the view that the B cell defect of CBA/N X C3H/HeN F1 male mice does not relate to antigen binding, but rather to an inability to be effectively triggered by certain cell-bound polymeric antigens.

Notes: Results of a population study with all currently available B-cell specific alloantisera indicate that eight antigens controlled by the RhLA-linked DR locus can now be identified. This leaves a gene frequency of about 0.15 for unidentified or ‘blank’ antigens of that locus. Of the nine identifiable la antigens which are not controlled by the DR locus, three or four may form the basis of a second series which is probably also controlled by the RhLA region.

Notes: Induction of tolerance to bovine serum albumin was studied in mice selected for high (H) or low (L) antibody responsiveness and in their F1 hybrids. No high or low zone tolerances were obtained in H mice whereas L mice were susceptible to tolerance induction by the two schedules. H mice were immunized by repeated injections of tolerogenic BSA for low zone tolerance induction but not after the administration of a single high dose of tolerogenic BSA. Resistance to tolerance induction is dominant in F1 hybrids.

Notes: An attempt is made to account for immunoglobulin chain synthesis in terms of genetic events involving IS or controlling elements analogous to those found in bacteria, maize and drosophila. Transposition of variable and constant genes and normal immunoglobulin chain synthesis as well as qualitative and quantitative abnormalities might be explained by such regulatory elements. Intrachromosomal transpositions over short distances would be expressed as apparent hypermutability or redundancy of the variable DNA segment. The constant gene might comprise four sequences coding for the three homology domains and the hinge, separated by intervening sequences. A strong preference for shortrange transposition on the same chromosome and immobilization of the controlling element in the end might account for allelic exclusion.

Notes: Fab2 fragments from antisera raised in rabbits with partially purified cellular and serum HLA antigens were tested for their ability to block the cytolytic activity of operationally specific HLA-A, B alloantisera. One Fab2 fragment preparation blocked the cytolytic activity of all the HLA-A,B alloantisera tested; the remaining nine inhibited the lytic activity of alloantisera to certain HLA-A,B allospecificities, suggesting that these xenoantisera contain antibody to certain HLA-A,B allotype determinants or to closely associated structures. In contrast to previous reports in the literature none of the xenoantisera contained significant amounts of antibodies to human β2-microglobulin.

Notes: NIM-M8 is a monoclonla IgM antibody, specific for the LWab antigen as shown by its reaction with red cells of all donors except those lacking LWa, LWb and LWab. Indirect immunofluorescent staining and cell sorter analyses have shown that LWab is present on a subpopulation of human lymphoctes. Cell fractionation studies indicate that subsets of both B and T cells express LWab and it may, therefore, provide a further marker for heterogeneity in these lymphocyte populations.

Notes: Immunoprecipitation using a monoclonal antibody showed that the Wrb antigen is present on the abnormal (δ-α) hybrid sialoglycoprotein of Sta-positive human erythrocytes but not on the abnormal (δ-α) hybrid sialoglycoprotein of Dantu-positive erythrocytes. These results provide further information regarding the nature and location of the Wrb antigen on the normal erythrocyte sialoglycoprotein α.

Notes: We studied structural and functional characteristics of lymphocytes from adult and fetal baboons (Papio cynocephalus). Flow cytometry with monoclonal antibodies to human lymphocyte antigens and plant lectins was used to define expression of surface antigens on lymphocytes from adult and 140 day fetal baboons (term = 180 days). Major T cell antigenic determinants on adult and fetal baboon lymphocytes were the Tp50, Tp32-45, and p45 glycoproteins detected by monoclonal reagents T11, OKT8, and OKT10 respectively. Baboon T lymphocytes did not react with the OKT3/anti-Leu4 or OKT4/ anti-Leu3a reagents which detect, respectively, Tp19-29 and Tp55, major surface glycoproteins on human T lymphocytes. OKT6, which identifies the human TL antigen equivalent on thymocytes, did not react with baboon thymocytes. These data demonstrate major evolutionary divergence between human and baboon T lymphocytes. By contrast, baboon lymphocytes resembled human peripheral lymphocytes in reactivities with several non-T cell reagents. Lectin binding studies revealed substantially fewer peanut agglutinin-and wheat germ agglutinin-binding cells in suspensions of baboon fetal splenocytes and adult peripheral lymphocytes compared with fetal thymocytes. Thereffore, maturation of baboon T lymphocytes is associated with loss of surface carbohydrate structures that bind these lectins. Adult and fetal baboon lymphocytes resembled human and murine lymphocytes in their capabilities to respond to mitogens and to produce interleukin-2. As in oter species, adult, but not fetal baboon lymphocytes, mediated NK activity against a variety of nucleated target cells. Despite divergence in lymphocyte antigen epression, babbon lymphocyte functional development colsely parallels that seen in humans.

Notes: The Gm, Am and Km immunoglobulin allotypes and ABO blood groups were studied in three groups of Tunisian Berbers.The results showed that the actual Berbers of Tunisia present certain heterogeneity and their ancestors were probably the first inhabitants of North Africa. Indeed, although their Gm-Am haplotypes are mainly Caucasoid, some of them are typically African.The group of Kesra village, the most Caucasoid, shows frequencies of Gm-Am haplotypes very close to those of South European populations, particularly the Spanish, who are probably of the same origin. The gene frequencies of the ABO groups in the three Berber groups were similar to those recorded in European populations with a relatively high frequency of the O genes typical of the Berbers.

Notes: Monoclonal antibody 212.i.4.2 mediated complement-dependent lysis of spleen and lymph node cells carrying the tw1, tw12, tw71, t6, tw73, and tLub1 haplotypes, while cells from mice carrying 11 other t haplotypes were not lysed. The antibody also detected an epitope controlled by genes in the H-2Dd region of non-t mice. A molecule of 46,000 molecular weight was immunoprecipitated by 212.i.4.2 from detergent extracts of 125I-labelled spleen cells of +/tw12 and B10.D2 mice. The H-2dm2 mutation did not alter the expression of the epitope recognized by 212.i.4.2. However, the H-2dm1 mutation decreased the reactivity of lymphoid cells with the antibody in cytotoxicity tests, and 212.i.4.2 immunoprecipitated little or no protein from extracts of B10.D2(R106) spleen cells which carry the H-2dm1 mutation.

Notes: Spleen cells from Balb/c mice given multiple injections of intact human erythrocytes (group O, NN) were fused with NS1 myeloma cells. Culture fluids from the resulting hybrid cells were screened for agglutinating antibody against a panel of erythrocytes. One cell line, 2/23, secreted an IgM antibody which reacted more strongly with NN than with MM cells. Neuraminidase or papain treatment of erythrocytes abolished agglutination whereas trypsin treatment did not. Reactions with U-erythrocytes of different MN phenotypes confirmed the anti-N specificity of monoclonal antibody 2/23. This is the first report of monoclonal anti-N stimulated by the immunization of mice with intact erythrocytes.

Notes: Spleen cells from 30 individual murine irradiation chimeras of the type (P1 x P2)F1→ P1 were compared in a rosetting assay for H-2K and H-2D cell surface antigen expression with normal (P1 x P2)F1 hybrid controls. Eleven out of the 30 chimeras were in the normal range, but the other 19 differed from F1 controls by 4- to 100-fold in endpoint titre for at least one H-2K or H-2D antigen. Every possible class of variation was found, i.e. up or down variation of H-2K or H-2D antigens of P1 or P2 type. This evidence, together with data from T6 chromosome marker experiments which also showed full reconstitution of lethally irradiated P1 recipients by (P1 x P2)F1 donor lymphomyloid stem cells, suggested that incomplete reconstitution was not the cause of H-2 antigenic variation.Low expression of P2 H-2 antigens on spleen cells derived from (P1 x P2)F1→ P1 chimeras was investigated further. Fifteen lethally irradiated (P1 x P2)F1 recipients of bone marrow cells from two such chimeras were all of normal F1 H-2 phenotype when tested 10-12 weeks after reconstitution, thus excluding stable, low P2 H-2-expressing variant F1 stem cells as a cause of the phenomenon. If P1 recipients were hyperimmunized against P2 cells before lethal irradiation and reconstitution with (P1 x P2)F1 stem cells, there were significantly fewer Till-McCulloch colonies in their spleens 10 days after reconstitution than in spleens of unimmunized controls. Also 〉 90% of immunized recients died by 6 weeks after stem cell injection but two survivors both showed very low levels of P2 H-2K and H-2D antigens. These results together with previously published evidence of anti-P2 Tc cell activity and P2 skin graft rejection in (P1 x P2)F1→ P1 chimeras suggested that residual anti-P2 immunological capability in lethally irradiated P1 recipients may be associated with low P2 H-2 expression on their F1-derived spleen cells, although the mechanism does not involve selection of stable, variant F1 stem cells. The mechanism(s) of other classes of variation in H-2 expression in (P1 x P2)F1→ P1 chimeras were not investigated.

Notes: RNA was extracted from the splenocytes of Brucella abortus antigen stimulated mice and of control mice. The proportion of chromatographically separated polyadenylated 11.2S mRNA, was determined. With the technique used, only stimulated mice exhibited significant amounts of this RNA species. The highest level was reached 1 day after the stimulation, and the decay from this level presented an oscillatory form during the 4 weeks following the injection.In two different genetic backgrounds, H-2b mice did not respond to the stimulus, in contrast to H-2a and H-2f mice. H-2b/H-2f heterozygotes behaved roughly as intermediate between H-2b and H-2f mice. This genetic control seems to parallel the genetic control of some Brucella-induced, thymus-dependent events previously described.

Notes: Book Reviews in this ArticleR. WITKOWSKI and O. PROKOP: Genetik erblicher Syndrome und Mgbildungen. Worterbuch fur die Familienberatung.

Notes: Monoclonal anti-Ia inhibition experiments were conducted to confirm and extend genetic mapping data of I-A gene control of immunity to human haemoglobin (Hb). It was found that the Aβ gene is of critical importance in conferring immunity to the α-chain and β-chain subunits of Hb. A possible involvement of I-E region genes in B10.D2 mice to β-chain is discussed. Through the use of an α-chain specific T cell clone data, is obtained indicating that an intact Ia.8+ Aβ chain is necessary for antigen presentation in vitro.

Notes: C4 is composed of two tightly linked genes (C4A and C4B) lying within the major histocompatibility complex of chromosome 6 that can be demonstrated by agarose gel electrophoresis. Seven alleles and five alleles at the C4A and C4B loci, respectively, were detected in 169 black individuals from the southeastern United States. Furthermore, the phenotypic frequencies of C4A6, C4A5, C4A4, C4B4, C4B3, and C4BQO were significantly different between black and white Americans.

Notes: Two B complex genotypes, B1B1 and B19B19, of outbred line S1, were tested for low and high immune response to GAT, from which four recombinants were recovered: B1B1 GAT-hi and lo, and B19B19 GAT-hi and -lo. Also included in the study were birds of B2B2 genotype with an intermediate level of immune response to GAT.A total of 225 birds of these groups were challenged with the Bryan strain of Rous Sarcoma virus subgroup C, RSV (RAV-7), by inoculation into the wing web at five weeks of age. The B1B1 genotype had the lowest percentage of regressors (17.6%), B19B19 had the highest (42.2%), and the B2B2 genotype was intermediate (23.7%). Combining the results of GAT response over the B1B1 and B19B19 genotypes, 14.0% of GAT-lo and 37.8% of GAT-hi regressed their tumours, respectively. The highly significant (P ≤ 0.01) difference between the combined GAT-hi and -lo groups would suggest that the Rs locus controlling tumour regression induced by the subgroup C virus is closely linked to the region controlling immune response to GAT, but the data also provides evidence that the B-F region of the B complex also plays an important role in RSV-induced tumour regression.

Notes: Surface immunoglobulin on spleen cells from NZB and NZB/W mice and congenic mice bearing the nude or X-linked immune defective (Xid) gene was examined by flow microfluorometry with regard to both the frequency of positive cells and density expressed on the cell. These data indicate that although the frequency of unseparated sIg+ B lymphocytes is equivalent among all of these groups of mice, the densities of sIgM and sIgD are different. Spleen cells from these mice were also separated by free-flow electrophoresis and analyzed in a similar manner. This analysis demonstrated the absence of a subpopulation of B lymphocytes with a low electrophoretic mobility and low expression of sIgM. These studies suggest that maturational and/or activation states of the B cells in mice bearing the Xid or nude genes are different from those seen in the parent strains of mice. Such alterations in cell-surface antigens correlate with differences in the natural history of immunopathology of the autoimmune disease in these congenic colonies of New Zealand mice.

Notes: Fifty-five Caucasoid patients with polymalgia rheumatica (PMR) or giant cell arteritis (GCA) were immunoglobulin (Gm) allotyped for this study. Forty-four of these patients had been previously HLA-A,B,C and DR locus allotyped. The incidence of the immunoglobulin allotypic marker Glm(2) was significantly increased in the GCA group (50.00% v. controls 18.75%, P= 〈0.01). There was a similar but insignificant rise of this Gm marker in the PMR group (27.24% v. 18.75%, NS). The increase in Glm(2) in the GCA group was not accompanied by a corresponding rise in the number of people homozygous for Glm(2), i.e., all the increase could be attributed to patients with the Glm(1,2,3): G3m(5,10,21) phenotype.

Notes: The strains B 10.S(7R), B 10.S(23 R) and B 10.S(24R), all thought to be genetically identical, differ in levels of susceptibility to infection with Trichinella spiralis. In a series of nine independent experiments, B 10.S(7R) was shown to be more susceptible than the other two strains. In another series of seven experiments, the strain B 10.A(18R) was shown to be more susceptible to infection with T. spiralis than the strains B 10.S(21R) or B 10.BAR-5, all of which were thought to share common H-2 alleles. These results indicate that a gene mapping between the S and D loci influences susceptibility to infection with T. spiralis. Typing of these strains for Qa and Tl loci rule out the possibility of a double crossover accounting for the differences observed. The new gene is designated Ts-2. Previously published data have also been reinterpreted and another gene Ts-1 is shown to be associated with the Aβ locus. When the d allele is expressed at the Ts-2 locus, strains of mice expressing s, q, f or b alleles at Ts-1 are rendered more susceptible to infection.

Notes: IgG and IgA heavy chain allotypes were determined in the sera of 483 Caucasian Type 1 diabetes patients and 503 Caucasian healthy controls. There was no significant difference between patients and controls neither on the level of Gm phenotype frequencies nor on the level of Gm three-locus and two-locus haplotype frequencies. A selective IgA deficiency was found in 14 patients (2.9%) but in none of the control individuals (P〈10-4).

Notes: Gm allotypes were detected and quantitated by radioimmunoassay (RIA) in paired serum and CSF samples from patients suffering from various neurological diseases. Of 115 patients with neurological disorders (65 MS and 50 others), seven subjects displayed one or two allotypes in their CSF which were absent in serum. The Gm phenotype in the patient's serum allowed us to infer the genotype without the need of familial data. A comparison of the regression curves obtained in RIA from the unexpected allotype in CSF and the counterpart in a normal serum pool argued for an identity of the Gm antigen carried by both inhibitory molecules. The unexpected allotype(s) in CSF can be considered as the product of a latent Gm gene which may be activated by either immune perturbations due to the disease per se or some particular immune regulations in the central nervous system.

Notes: Book reviewed in this article:N. Catsimpoolas; Cell Analysis. Plenum Publishing CorpJ.W.Shay: Techniques In Somatic Cell Genetics

Notes: Immunoprecipitaon studies of the rhesus monkey major histocompatibility system have shown that the RhLA-DR locus codes for class II antigens with molecular features that are homologous to the class II antigens coded for by the human HLA-dR locus, The products of another alloantigenic RhLA-linked locus of the rhesus monkey, called ‘48’, is provisionally characterized as a class I system.

Notes: The relationships between the antigens recognized by four monoclonal anti-human ‘Ia’-like antibodies were investigated using sequential immunoprecipitation and capping techniques. Two of the antibodies were ‘monomorphic’ and have previously been shown to recognize epitopes in which carbohydrate residues are involved, whereas the two ‘polymorphic’ antibodies recognized protein-defined epitopes—one of these epitopes being present on MB+DR- molecules. In the absence of an indisputable anti-DR monoclonal antibody, it was not possible to conclusively verify which ‘Ia’-encoded antigens were detected by the anti-‘Ia’-like monoclonal antibodies. Nevertheless, several firm conclusions could be drawn: (a) so-called ‘monomorphic’ antibodies do not necessarily react with all ‘Ia’ molecules encoded by a single locus—from the results using the two monomorphic antibodies, B5.1 and 3F1.1, described herein, two populations of antigens being B5.1+3F1.1+ and B5.1+3F1.1- were identified; (b) cross-reactivity of a polymorphic determinant expressed on antigenically-separable ‘Ia’ molecules was noted—using the two polymorphic antibodies, 26.1 and F5C9, molecules which were 26.1+F5C9+ and 26.1-F5C9+ were identified; and (c) the data clearly point to the existence of at least two loci coding for ‘Ia’-like antigens (one of which may or may not be the HLA-DR locus). Given that polymorphisms can now include protein- and carbohydrate-defined epitopes, that cross-reactions occur and that the definition of DR itself by monoclonal antibodies is not clear, the complexity of the human ‘Ia’ antgens is apparent.

Notes: We report HLA genotypes in four familial cases of Hodgkin's disease (HD), Nodular Sclerosis (NS) histological subtype, where all patients showed B18 antigen. This finding, although statistically not supported, confirms the possible correlation between HD and B18 antigen which carries a high relative risk in international data.

Notes: Previous studies from this laboratory have resulted in the determination of the antigenic structure of sperm-whale myoglobin (Mb). In the present work, we have investigated the fine specificity requirements for T-cell recognition of one of the Mb antigenic sites (antigenic site 5). The antigenic site (peptide 145-153) and seven progressively longer peptides, increasing in length stepwise by two residues at a time, up to 22 residues in length (peptide 132-153), were synthesized. In addition, four truncated peptides were synthesized with intentional deletions at Tyr- 151 and Ala- 144. The T-cell recognition of these purified synthetic peptides was examined here in detail in three strains of mice (BALB/cByJ, B10.D2/n and SJL/J). Mb-primed mice afforded T-cells which proliferated to smaller peptides (two or four residues longer than the site; i.e. peptides 145-153 and 143-153) and more so to the longer peptides 135-153 and 132-153 and to Mb. No response was obtained to the truncated peptides, thus underscoring the fine specificity T-cells. No response was obtained also to intermediate-sized peptides. The latter result, due to an unfavourable mode of folding, suggested a conformational dependency in T-lymphocyte recognition.

Notes: Serum blood samples from 563 of the total 700 Nganasans, members of the isolate in the northern-most part of Siberia were tested for G1m, (z,a,x,f), G2m (n), G3m (g,b0,b1,b3,b5,s,t), and km (1) allotypic determinants. Additionally, 78 Yenisey Samoyeds (Entsi) who are the Nganasan's western neighbours were studied. Both populations are remarkable for high frequency of ‘Northern Oriental’Gm (za;.;b0b3b5st) which appears to be the most frequent haplotype in the Nganasans (0.486), and is the second frequent in Yenisey Samoyeds (0.276). The Gm (f;b) generalized haplotype which used to be considered as an indicator of Caucasian gene flow occurred in the Nganasans in the very low frequency of 0.008, versus 0.045 revealed in adjoining Yenisey Samoyeds. Both populations also differ in the frequency of Km1 which is two times lower in the Nganasans (0.048), than in Yenisey Samoyeds (0.103). When segregation ratios for the Gm locus were inspected in 67 Nganasan families, no apparent deviations from Mendelian expectations, and no recombinant phenotypes were observed.

Notes: Genetic control of PQ prolongation of the electrocardiogram (ECG) in the mouse, immunized with killed group A streptococci, was studied by using various congenic mice. Mice of H-2a, H-2k and H-2f haplotypes showed high frequencies of PQ prolongation, while haplotypes of H-2b, H-2d and H-2s showed low frequencies of PQ prolongation. Studies using various recombinant mice revealed that at least one immune-associated (Ir) gene mapped in the left side of the I-B subregion. High responsiveness of F1 hybrids of H-2b and H-2d, as well as B1O.A(5R) and B10.A(3R), suggests the existence of a complementing gene. In addition, the differences between C3H and CKB, as well as differences between C3H.SW and CWB, indicate that another Ir gene maps in the immunoglobulin heavy chain (Igh) coding loci. Repeated injections of anti-I-J or anti-I-A antisera also modified this PQ prolongation. These results suggested that both the major histocompatibility complex (MHC) and immunoglobulin (Igh) loci seem to be playing important roles in the pathogenesis of PQ prolongation.

Notes: The growth and reproduction complex contains recessive genes (grc) which influence body weight and gonadal development. Homozygous males are sterile, and they have an arrest of spermatogenesis at the primary spermatocyte stage. Homozygous females are fertile but have a reduced reproductive capacity. The data presented in this paper show that the latter defect is associated with a decrease in the relative number of secondary ovarian follicles and an increase in the number of atretic follicles. This finding indicates that most of the primary follicles do not mature properly. Thus, the genetic defect in gametogenesis controlled by the grc appears to occur at the same stage of development in both females and males.

Notes: Austrian business cycle policy was unconventional but rather successful in the last three decades and especially since the oil crisis. The unconventional conception was developed by trial and error, only ex post it got the name Austro-Keynesianism. Nevertheless it has a theoretical basis, a rather radical interpretation of KEYNES, which bases economic instability on a deep-rooted uncertainty of entrepreneurs. According to this interpretation economic policy tried to stabilize the data most important for entrepreneurial decisions, especially wage increase, exchange rates and investment promotion. This lightened the burden of the traditional instruments of stabilization policy. In addition these instruments were assigned differently: Exchange rate policy was primarily used to stabilize prices in the short run, incomes policy to equilibrate the current account in the medium and longer run, fiscal policy to stabilize employment. While the new assignation proved useful for stabilization policy, some structural problems remained unsolved.

Notes: Implications of inefficiency in theories of market failure reveal a flawed methodology. Behavior which is apparently inefficient is actually the symptom of an inappropriate analytical model. The standard examples of market failure, monopoly power and external effects, are forthcoming only from models which omit transactions costs as explanatory variables. The unfortunate consequence of this conclusion is that complete and appropriate economic models, which incorporate all relevant variables, will always certify any behavior as efficient. This poses the ‘Panglossian dilemma’, that whatever is, is optimal. This dilemma is resolved by an analytical approach which compares behavior under alternative economic institutions. This analysis depends on two propositions: that transactions costs are affected by alternative institutional environments; and that institutions are themselves responses to the existence of transactions costs. These propositions are used to predict behavior under alternative institutions, and to explain the long run evolution of the institutions.

Notes: Empirical evidence does not agree with the investment-model of the demand for education: out of pocket costs have another impact than earnings foregone. This difference can be explained by consumption motives. The demand for education is then greater, the full price of education exceeds discounted future incremental earnings, net discounted wealth is not maximum and the rate of return to marginal investments in education is smaller than the interest rate.

Notes: At the turn of this century WESLEY C. MITCHELL argued that the velocity of money could be influenced by a noneconomic variable that he called ‘confidence’; but the idea has received little attention since then. This study uses events in the long Vietnam war for statistically demonstrating the MITCHELL hypothesis. U. S. troop presence in South Vietnam boosted the peoples' confidence in their country's future thereby stabilizing the demand for fiat money and income velocity. Only two variables - the previous year's rate of inflation and U. S. troop strength, which serves as a proxy for battlefield victories - are needed to explain movements in velocity.

Notes: Al-Shaikhly, Salah (ed.): Development Financing.Bombach, G.; Netzband, K.-B.; Ramser, H.-J. und Timmermann, M. (Hrsg.): Der Keynesianismus III.De Jong, H. W. (ed.): The Structure of European IndustryDesai, Meghnad: Testing MonetarismDiekmann, Jochen: Kontrctkttheoretische ArbeitsmarktmodelleDunning, John H.: International Production and the Multinational EnterpriseEliasson, Gunnar and SÖdersten, Jan (eds.): Business Taxation, Finance and Firm Behavior.Gandolfo, Giancarlo: Qualitative Analysis and Econometric Estimation of Continuous Time Dynamic ModelsGiersch, Herbert (ed.): Macroeconomic Policies for Growth and Stability.Heertje, Arnold (ed.): Schumpeter's Vision.Herder-Dorneich, Philipp; Sieben, Gunter und Thiemeyer, Theo (Hrsg.): Beitrdge zur GesundheitsÖkonomie.Herdzina, Klaus: Wirtschaftliches Wachstum, Strukturwandel und WettbewerbHowey, Richard S.: A Bibliography of General Histories of Economics 1692-1975Hutchison, T. W.: The Politics and Philosophy of Economics International Economic Policy Research.Judge, George G.; Hill, R. Carter; Griffiths, William; LÜtkepohl, Helmut and Lee, Tsoung-Chao: Introduction to the Theory and Practice of EconometricsKamien, Morton I. and Schwartz, Nancy L.: Market structure and innovationKornai, JÁnos and Martos, BÉla (eds.): Non-price controlLouven, Erhard : Technologietransfer und angepasste Technologien.Malliaris, A. G. and Brock, W. A.: Stochastic Methods in Economics and FinanceOchel, Wolfgang: Die Entwicklungsländer in der Weltwirtschaft.Panchamukhi, P. R.: Inequality in EducationPatinkin, Don: Essays on and in the Chicago TraditionPrais, S. J.: Productivity and Industrial Structure.Preston, A. J. and Pagan, A. R.: The Theory of Economic Policy.RomÁn, ZoltÁn : Productivity and Economic GrowthRÜrup, Bert und KÖrner, Heiko: Finanzwissenschaft.Sachverständigenrat zur Begutachtung der gesamtwirtschaftlichen Ent-wicklung: Investieren für mehr Beschäftigung.Schenk, Karl-Ernst: Märkte, Hierarchien und Wettbewerb.Schenk, Karl-Ernst: ≪Institutional Choice〉 und OrdnungstheorieSchneider, Diethard: Monetäre Konzepte der Verstetigungspolitik.Schotter, Andrew: The Economic Theory of Social InstitutionsSchultz, Theodore W.: Investing in People.Shackleton, J. R. and Locksley, Gareth (eds.): Twelve Contemporary Economists.Shone, Ronald: Applications in Intermediate Microeconomics

Notes: Books reviewed in this article.Bender, Dieter et al.: Vahlens Kompendium der Wirtschaftstheorie und Wirtschaftspolitik.Betancourt, Roger R. and Clague, Christopher K.: Capital Utilization.Blankart, Charles Beat und Faber, Monika (Hrsg.): Regulierung öffentlicher Unternehmen.Brune, Heinrich-Gustav : Organisation von Verbraucherinteressen.Charatsis, E. G. (Ed.): Proceedings of the Econometric Society European Meeting 1979.Cooper, Charles : Economic Evaluation and the Environment.Courbis, Raymond (Éd.): Commerce international et modèles multinationaux.Diebold, William Jr.: Industrial Policy as an International Issue.Ekelund, Robert B. Jr. and Tollison, Robert D.: Mercantilism As a Rent-Seeking Society: Economic Regulations in Historical Perspective.Ferber, Robert and Hirsch, Werner Z.: Social Experimentation and Economic Policy.Fisher, Anthony C.: Resource and Environmental Economics.Gottwald, Dietrich: Die dynamische Theorie der Allokation erschöpfbarer Ressourcen.Griffith-Jones, Stephany: The Role of Finance in the Transition to Socialism.GrÜnÄrml, Frohmund: Multinationale Unternehmen, internationaler Handel und monetäre Stabilität.Hudson, John : Inflation.Hueting, Roefie : New Scarcity and Economic Growth.Kornai, JÁnos: Economics of Shortage.Krämer, W.: Eine Rehabilitation der gewöhnlichen Kleinst-Quadrate-Methode als Schätzverfahren in der Ökonometrie.Krohn, Claus-Dieter: Wirtschaftstheorien als politische Interessen.Llewellyn, David T.: International Financial Integration.Minx, Eckard : Von der Liberalisierungs- zur Wettbewerbspolitik.Mooslechner, Peter und Nowotny, Ewald: Gesamtwirtschaftliche Finanzierung und öffentliche Verschuldung.Moss, Scott : An Economic Theory of Business Strategy.Newbery, David M. G. and Stiglitz, Joseph E.: The Theory of Commodity Price Stabilization.Ryll, Edwin: Abschöpfungssystem, Angebotskontingentierung, produktneutrale und produktgebundene staatliche Einkommensübertragungen als agrarmarktpolitische Instrumente.Sauernheimer, Karlhans: Internationale Kapitalbewegungen, flexible Wechselkurse und gesamtwirtschaftliches Gleichgewicht.Shelp, Ronald Kent : Beyond Industrialization.Sid-Ahmed, Abdelkader : Nord-Sud: Les enjeux.Siebert, Horst:. Economics of the Environment.Slawson, W. David : The New Inflation.Stahl, Konrad und Sghulz, Norbert: Mathematische Optimierung und mikroökonomische Theorie.Thimm, Alfred L.: The False Promise of Codetermination.Witt, Ulrich: Marktprozesse.

Notes: Ahmad Jaleel: Import Substitution, Trade and Development.Berendsen B. S. M.: Regional Models of Trade and Development.Binswanger Hans P., Ruttan Vernon W., and others: Induced Innovation.Arndt Helmut: Irrwege der Politischen Ökonomie.Barry Thomas and Deaton David: Labour Shortage and Economic Analysis.BÉziade Monique: La monnaie.Coulbois Paul: Finance Internationale.Deiss Joseph: Monnaie et Prix internationaux.Brooks John and Evans Robert W.: Macroeconomic Policy in Theory and Practice.Cook S. T. and Jackson P. M. (Eds.): Current Issues in Fiscal Policy.Eckstein Otto: The Great Recession.Fraenkel Gioachino: Elementi di teoria e di politica monetaria.Freeman A. Myrick, III: The Benefits of Environmental Improvement.Guindey Guillaume: Mythes et Réaltiés de la Crise Monétaire Internationale.Hazari Bharat R.: The Pure Theory of International Trade and Distortions.Hettlage Robert: Genossenschaftstheorie und Partizipationsdiskussion.Hicks John: Economic Perspectives.Johansen Leif: Lectures on Macroeconomic Planning.Major Robin (Ed.): Britain's Trade and Exchange-Rate Policy.Passet RenÉ: L'économique et le vivant.Roll Eric (Ed.): The Uses and Abuses of EconomicsRostow W. W.: Getting from Here to There.Teighmann Ulrich: Wirtschaftspolitik.Vane Howard R. and Thompson John L.: Monetarism.Williams Ph. L.: The Emergence of the Theory of the Firm.Woll Artur (Hrsg.): Inflation.

Notes: This article critically reviews the development and present state of information theory in labor markets. Since the first generation of the new microeconomics, important progress has been made. However, a compact theory including both the various forms of information problems and the associated behavioral reactions still does not exist. Much work remains to be done in order to achieve a general and comprehensive foundation of macroeconomics. Moreover, application of such models to reality is not possible because there are no conclusive empirical tests. The strict neoclassical approach used in these models must be regarded as their principle weakness. The more reality differs from neoclassical assumptions, the more important is the — complementary — macro foundation of micro economics. This should include the analysis of collective decisions on the macro level and their effect on the individual market participant. Finally, some recent empirical and theoretical ideas are presented.

Notes: This paper is intended to highlight the role of cost increases in the inflation process. In the course of the analysis a distinction is made between three different types of cost inflation: (i) exogenous cost impulses; (ii) competing income claims, both by way of bargaining in markets and by competition in the political arena; and (iii) attempts to preserve the purchasing power of income. Each category is discussed in some detail. The paper also discusses alternative methods of fighting cost inflation, including some issues pertaining to cost-accommodating demand management and incomes policy.

Notes: According to Kondratiefflong term economic growth in industrialized countries is characterized by a 40- to 60-years-long cycle. The existence of this cycle is much debated. This article presents a spectral analytic test of the long cycle on the basis of price and volume series for Great Britain, France, Germany and the United States. In addition, long cyclical relations between prices and production and the relations between these variables internationally are analyzed by means of cross spectral analysis. The results of these analyses seem to confirm the existence of a Kondratieff-cycle in prices, but contradict the existence of a (simultaneous) long cycle in real variables.

Notes: This paper is an empirical investigation of the hypothesis that there exists a positive relationship between the inflation rate and its variability. The hypothesis is tested for a sample of eighteen industrial countries for the period 1949-1970. In contrast to most previous studies, policy makers are allowed to revise their desired inflation rate by calculating a six-year moving average. The homogeniety assumption across countries is relaxed and the relationship between the average inflation rate and its variability over time is examined within each country. In addition, the argument that government financial policy is responsible for the variability of the inflation rate is reexamined in the context of a fixed-exchange-rate open economy; an alternative source of inflation variability is proposed-international inflation. A procedure that separates out the influence of the world inflation rate is developed and the relationship between the average inflation rate and its measure of variability attributable to domestic government financial policy is examined. The findings of this study provide less pervasive support than previous studies of the existence of a positive relationships between the inflation rate and its variability. Moreover, the positive causality uncovered might be due more to international inflation than to the actions of domestic financial authorities.

Notes: The life cycle hypothesis of consumption and rational (in the sense of Muth) expectations implies under certain additional, but not very restrictive, assumptions that real consumption follows an univariate first order autoregressive process. This implication was tested in the framework of bivariate autoregressive models with Swiss quarterly macroeconomic data. A slightly modified variant of the stepwise modelling approach suggested by Hsiao was applied. The hypothesis was rejected with respect to a ‘Neo-Ricardian’ definition of disposable income and real stock prices. By contrast, the test with the conventional definition of disposable income brought not significant results. These findings rise some doubts about the usual specification of macroeconometric consumption functions and their policy implications.

Notes: Auernheimer, Leonardo and Ekelund, Robert B. Jr.: The Essentials of Money and Banking.Batchelor, R. A.; Major, R. L. and Morgan, A. D.: Industrialisation and the Basis for Trade.Boettcher, Erik: Die Genossenschaft in der Marktwirtschaft.Brems, Hans: Dynamische Makrotheorie - Inflation, Zins und Wachstum.von Brentano, Dorothee: Grundsätzliche Aspekte der Entstehung von Genossenschaften.BÜrgenmeier, Beat: Théorie et pratique des investissements suisses à l’étranger.Cassen, Robert et al.: The World Development Report 1981.Cline, William R. and Associates: World Inflation and the Developing Countries.Craven, John: The Distribution of the Product.Deaton, Angus (Ed.): Essays in the theory and measurement of consumer behaviour.Dell, Sidney and Lawrence, Roger:The Balance of Payments Adjustment Process in Developing Countries.Fallick, J. L. and Elliot, R. F. (Eds.): Incomes Policies, Inflation and Relative Pay.Fellner, William(Ed.): Contemporary Economic Problems 1980.Frohn, Joachim und StÄglin, Reiner(Hrsg.): Empirische Wirtschqftsforschung.Gutzler, Helmut(Hrsg.): Umweltpolitik und Wettbewerb.Hamm, Walter und Schmidt, Reimer(Hrsg.): Wettbewerb und Fortschritt.Hey, John D.: Economics in Disequilibrium.Hibbs, Douglas A., Jr. and Fassbender, Heinowith the assistance of Rivers, R. Douglas(Eds.): Contemporary Political Economy.Howard, M. C.: Modern Theories of Income Distribution.Kellenbenz, Hermann: Deutsche Wirtschaftsgeschichte.Kocher, Gerhard und Rentchnick, Pierre:Teure Medizin.Kraft, M. und Braun, K.: Statisttsche Methoden für Wirtschafts- und Sozialwissenschaften.Maxwell, Robert J.: Health and Wealth.Mishan, Ezra J.: Introduction to Normative Economics.Sen, Amartya: Poverty and Famines.StÖhr, Walter B. and Fraser Taylor, D. R. (Eds.): Development from Above or Below? The Dialectics of Regional Planning in Developing Countries.Usher, Dan: The Economic Prerequisite to Democracy.Wagenhals, Gerhard: Wohlfahrtstheoretische Implikationen von Disparitätsmassen.

Notes: This paper summarizes recent developments in the stabilization policy debate. The emphasis is on the controversy between two main classes of models, the equilibrium and the disequilibrium approach, which are both aiming at a consistent explanation of macroeconomic price and quantity behavior. The various models that have been proposed are placed into a coherent framework, and the source of their contradicting policy implications is explored. Empirical evidence cannot be expected to bring about a clearcut decision in favor of either paradigm. A more likely prospect is the development of a synthetic approach emerging from current research in the micro foundations of macroeconomics. (An english version of this article is available as Discussion Paper Nr. 61, Institut f¨r angewandte Wirtschaftsforschung, University of Basel.)

Notes: Inflation occurs because individuals have an incentive to raise prices. The key issue of anti-inflation policy is to choose the appropriate incentive to stop inflation. Monetary policy works through the hunger incentive and it is no longer effective because society no longer allows the hunger incentive to work. This paper argues that the appropriate incentives to stop inflation are market incentives. These market incentives can be built into society through the introduction of an incentive anti-inflation plan such as the authors’ MAP proposal or its TIP counterparts.

Notes: Considerable controversy surrounds the COASE theorem despite the fact that it is generally accepted as valid both in the theory of externalities and the economic analysis of law. A major source of the controversy is the fact that there are a number of versions of the COASE theorem and definitions of transactions costs. It is argued that a proper understanding both of the competitive market model and transaction costs reveals that the COASE theorem is invalid and not part of standard market theory. It is further argued that transaction costs and information costs arising from market uncertainty provide a key to resolving many of the controversies that the theorem has given rise to and following from this that the primary economic function of law in bargaining situations is to increase transaction costs in order to reduce market uncertainty and strategic behaviour.

Notes: In this paper, three aspects of the potential gains form trade in an imperfect competition framework are considered in the light of recent research: the presumption that free trade reduces the monopolistic distorsions of imperfect domestic markets; the role of international openness as a way of making room for more efficient-size sellers in the domestic market; its effect upon the appearance of new products and increase in the total number of products. Theoretical and empirical research suggest that trade is indeed likely to improve allocative as well as technical efficiency and often to promote more product varieties.

Notes: Many governments allocate resources to the repression of the political freedom of their citizens. The dominant economic theory of this activity, associated most prominently with the work of HAYEK, is that political repression is a bi-product of the erosion of economic freedom. This theory predicts that civil liberty will be positively correlated with the degree of economic freedom. An alternative view, derived from models of industrial behavior, is that monopolistic governments will use political repression to protect their property rights, so that concentrated party systems will tend to engage in more repression than competitive systems. Using a cross-sectional sample of 184 states in 1979, an empirical test of the two hypotheses is presented and the evidence is shown to be more consistent with the second hypothesis. In addition, the correlation between civil liberty and a variety of economic variables is examined: the degree of civil liberty is found to positively related to the level of real per capita income and to the ratio of wage and salary payments to total income. The Gastil index of civil liberty provides the empirical foundation for the study.

Notes: The paper is the 1980 - Bohm-Bawerk - lecture given at the University of Innsbruck. Starting from Bohm-Bawerk's book Rights and Relations from the Point of View of the Economic Theory of Goods the paper tries to evaluate rights and phenomena like goodwill from the perspective of innovation. A framework of three levels of economic activity is developed. The three levels are consumption (the lowest level), production and innovation (the highest level). Rights are interpreted as instruments of protection of higher level activity from lower level activity. Focus of attention are industries with very high rates of technical progress and innovation. There the most important positive externality of innovation is the increased potential for even more innovations. It is argued that competition policy, as a rule of thumb, must foster competition by innovation and must discourage competition by imitation.

Notes: Allen, Polly Reynolds and Kenen, Peter B.: Asset Markets, Exchange Rates, and Economic Integration.Duwendag, Dieter und Siebert, Horst (Hrsg.): Politik und Markt.Eger, Thomas: Das regionale Entwicklungsgefälle in Jugoslawien.El-Agraa, Ali Mohammed and Jones, Anthony John: Theory of Customs Unions.Forster, Edgar und Vaassen, Bernd : Der Wettbewerb zwischen privater und gesetzlicher Krankenversicherung.Gehrig, Bruno: Geldpolitik unter alternativen institutionellen Voraus-setz. ungen.Hughes, Barry B.: World Modeling.Issawi, Charles : The Economic History of TurkeyJantsch, Erich: Die Selbstorganisation des Universums.Kakwani, Nanak C.: Income Inequality and Poverty.Kotte, Detlef J.: Wirkungen zwischenstaatlicher Finanztransfers in der EG auf Konjunktur und ZahlungsbilanzKÖtzle, Alfred : Die Eignung von Subventionen für die UmweltpolitikLaitinen, Kenneth : A Theory of the Multiproduct Firm.Lehment, Harmen: Devisenmarktinterventionen bei flexiblen Wechselkursen.Leroy, Dominique: Economie des arts du spectacle vivant.McKinnon, Ronald I.: Money in International Exchange.Noll, Werner: Finanzwissenschqft.Ohlsson, Lennart A.: Engineering Trade Specialization of Sweden and other Industrial Countries.Porschen, D.:Währungskooperation in West und Ost - Ein Systemvergleich auf der Grundlage der neuen politischen Ökonomie.Rohde, Wolfgang: Ein spieltheoretisches Modell eines Terminmarktes.Schmid, GÜnther: Strukturierte Arbeitslosigkeit und Arbeitsmarktpolitik.Shah, A. B. and Bhan, Susheela (Eds.): Non-Formal Education and the NAEP.Vallender, Dorle E.: Einführung in die Finanzwissenschaft.

Notes: This paper summarizes the conclusions of a number of studies prepared in recent years by the German Development Institute (Berlin) on the structural implications of the Southern enlargement of the European Community for the acceeding countries as well as for the whole EEC. Reference is made to the problems arising generally from the internal and external impact of the changes in the structural equilibrium of the Community, defined in terms of increasing structural disparities within the EEC and growing inflexibility vis-à-vis the rest of the world. The implications for the Common Agricultural Policy and the industry are then discussed with special reference to the problem of the ‘sensitive’ industries. Arguments are presented in favour of the thesis that a new structural equilibrium can only be achieved through the improvement of production structures in the weaker regions of the Community and so through the gradual elimination of the intra-Community development gap.

Notes: Bizien, Yves: Population and Economic Development.Black, John and Hindley, Brian (Eds.): Current Issues in Commercial Policy and Diplomacy.Brams, S. J.; Scmotter, A. and SchwÖdiauer, G. (Eds.): Applied Game Theory.Bruder, Wolfgang: Sozialwissenschaften und Politikberatung — Zur Nutzung sozialwissenschafthcher Informationen in der Ministerialorganisation.Clarkson, Kenneth W. and Martin, Donald L. (Eds.): The Economics of Nonproprietary Organizations.Dixon, P. B.; Bowles, S. and Kendrick, D.: Notes and Problems in Microeconomic Theory.Dobias, Peter: Wirtschaftspolitik.El Mallakh, Ragaei and Dorothea H. (Eds.): New Policy Imperatives for Energy Producers.Frey, RenÉ L.: Wachstumspolitik.Gollnick, Heinz und Thiel, Norbert : Ökonometrie.Gordon, Wendell: Institutional Economics.Gram, Harvey and Walsh, Vivian : Classical and Neoclassical Theories of General Equilibrium.Hacche, Graham: The Theory of Economic Growth. An Introduction.Hesse, Helmut (Hrsg.): Arbeitsbuch Angewandte Mikroökonomik.Hirsch, Werner Z.: Law And Economics: An Introductory Analysis.Kanemoto, Yoshitsugu: Theories of Urban Externalities.Klein, Lawrence R. and Young, Richard M.: An Introduction to Econometric Forecasting and Forecasting Models.Lavigne, Marie : Stratégies des pays socialistes dans l'echange international.Lindbeck, Assar (Ed.): Inflation and Employment in Open Economies.Lippman, S. A. and McCall, J. J. (Eds.): Studies in the Economics of Search.Lowe, Julian and Lewis, David : The Economics of Environmental Management.Peacock, Alan: The Economic Analysis of Government.Rao, C. H. Hanumantha and Joshi, P. C. (Eds.): Reflections on Economic Development and Social Change.Rossier, Edouard:.Economie structurale.Siebert, Horst and Antal, Ariane Berthoin : The Political Economy of Environmental Protection.Smith, Vernon L. (Ed.): Research in Experimental Economics. A Research Annual. Vol. 1.Uhlir, Helmut: Überprüfung der Random-Walk-Hypothese auf dem österreichischen Aktienmarkt.United Nations Industrial Development Organization: Industrial Priorities in Developing Countries.

Notes: The paper develops and renders plausible the hypothesis that modern man is developing an ever greater tolerance and desire for excitement and violence, because scientific and economic progress has so greatly diminished the hardships and hazards of everyday work and existence and of the fight for survival that most people are left with a stimulus deficit, which they try to eliminate. The various sources of deliberately sought-for stimulation, ranging from dangerous sports and gambling to violence, crime and participation in collective hazardous action, are listed and discussed, and the available statistics of their use or incidence compared and analyzed.

Notes: An otherwise conventional Keynesian macro model is modified to include inventories of final goods by (1) drawing a distinction between production and final sales, and (2) allowing for a negative effect of the level of inventories on production. Two models are presented: one in which the labor market clears and one in which it does not. Both models are stable only if the negative effect of inventories on production is ‘large enough’. Both models also imply that real wages move procyclically - in direct contrast to the usual implication of Keynesian models. Detailed analysis of the market-clearing model shows that there should be negative correlation between the levels of inventories and output, and between changes in inventories and changes in output, over the business cycle. However, inventory change should be positively correlated with the level of output.

Notes: This paper examines the effects of rising oil prices and dependence upon imported oil on inflation. For the United States, Japan, the Federal Republic of Germany, Sweden, the United Kingdom, and Australia, it is found that the price of imported oil is a significant cause of inflation. Dependence upon imported oil also is an important cause of inflation in Japan, the United States, and West Germany.

Notes: Für drei zentrale Ansätze der ökonomischen Theorie, den der walrasianischen Gleichgewichtstheorie, den der walrasianischen Unglcichgewichtstheorie und den der Neuen Mikroökonomie, werden die Komponenten der disziplinären Matrix, wie sie in dem von T. S. KUHN entwickelten wissenschaftstheoretischen Raster definiert sind, identifiziert. Ein exakter Vergleich dieser einzelnen Komponenten (das heisst der symbolischen Verallgemeinerungen, der metaphysischen Bestandteile, der Wertvorstellungen und der Beispiele) zeigt, dass sie sich so grundsatzlich unterscheiden, dass man von drei verschiedenen Paradigmata sprechen muss. In KuHNscher Terminologie zeichnen sich die Wirtschaftswissenschaften also (noch?) aus durch verschiedene Schulen, wie dies charakteristisch ist fur eine relativ friihe Phase der wissenschaftlichen Entwicklung.〈section xml:id="abs1-2"〉〈title type="main"〉SUMMARYFor three central branches of economic theory, the walrasian equilibrium theory, the walrasian disequilibrium theory and the New Microeconomics, the components of the disciplinary matrix, as they have been defined by the epistemological screen developed hy T. S. KUHN, are identified. An exact comparison of these specific components (i.e. the symbolic generalizations, the metaphysicaI parts, the values and the exemplars) shows that they differ so fundamentally that we must speak of three different paradigms. In KuHNian terminology, economics (still?) is featured by distinct schools, as it is characteristic for a relatively early staze of scientific development.

Notes: Allen T. Harrell: New Methods in Social Science Research.Bawa Vijay S., Brown Stephen J., and Klein Roger W.: Estimation Risk and Optimal Portfolio Choice.Bigksler James L. (Ed.): Handbook of Financial Economics.BlÜmle Gerold: Wirtschaftskreislauf, Beschäftigung und Inflation.Buomberger Peter : Theorie und Strategic der Geldpolitik in einer kleinen offenen Volkswirtschaft.Cipolla C. M. und Borchardt K. (Hrsg.): Sechzehntes und Siebzehnles Jahrhundert.CsikÓs-Nagy B.: Towards a New Price Revolution.Fine Ben and Harris Laurence: Rereading Marx.Hey John D.: Uncertainty in Microeconomics.Hunt E. K.: History of Economic Thought: A Critical Perspective.Lavigne Marie: Les relations économiquesMÜller JÜrgen und Vogelsang Ingo: Staatliche Regulierung.Mulvey Charles : The Economic Analysis of Trade Unions.Negishi Takashi : Microeconornic Foundations of Keynesian Macroeconomics.Paul Ellen Frankelm:Mo ral Revolution and Economic Science.Sargent Thomas J.: Macroeconomic Theory.SchÖnbÄck Wilfried : Subjektive Unsicherheit als Gegenstand staatlicher Intervention.Schrenk Martin, Ardalan Cyrus, and EL Tataway NawaL A.: Yugoslavia—Self-Management Socialism and the Challenge of Development.Siebert Horst: Ökonomische Theorie der Umwelt.Spatz Heinrich: Die Allgemeine Gleichgewichtstheorie.Whynes David K.: The Economics of Third World Military Expenditure.Wolfson Dirk J.: Public Finance and Development Strategy.

Notes: This paper is a survey of the most important contributions to the development of a theory of ‘long waves’ in capitalist development. From the early forerunners of the discussion, via Kondratieff and Schumpeter, to the economists of today, the debate on the long-wave phenomenon is being surveyed and assessed. The result is rather negative. No one has been able to empirically verify the existence of the long waves. Secular wave-like fluctuations in prices and certain related time series have been found - but these are quite compatible with explanations based exclusively on exogenous factors. In physical time series of production or other time series that are not directly correlated with prices, there has been no evidence of long waves. Nor has anyone been able to give a satisfying explanation of why the secular rate of growth or level of economic activity would fluctuate in a self-generating cyclical pattern. Therefore, we must draw the conclusion that those turning-points and successive trend periods which undeniably exist in the development of capitalism cannot be regarded as manifestations of some kind of long wave or cycle; instead, they are specific, historical occurrences, each one characterized by its own specific features. The task of the social scientist is, thus, to study the actual historical dynamics of the economic system - without trying to squeeze it into a general pattern of secular cyclical swings.

Notes: The starting point is the model of individual behaviour used by modern economic theory. The individualistically oriented branch of modern sociological theory is based on the same behavioural model, but stresses different aspects than economic theory does. While economic theory holds preferences constant and investigates how changes in the restrictions placed on individuals produce changes in their behaviour, sociological theory investigates how different social conditions give rise to different preferences (‘attitudes’) which then result in different ways of behaving. The theory of voting behaviour is given as an example to show how economic and sociological theory can gain from supplement each other. While sociological theory explains mainly long-term developments in voting behaviour as reactions to long-term changes in the society's basic social structure, economic theory mainly explains short-term variations in voting behaviour resulting from changes in economic and political factors. We conclude by discussing some misunderstandings held by sociologists concerning the economic approach. It is shown that once these misunderstandings are cleared up, economics not only can learn from sociology, but sociology can learn from economics as well.

Notes: This paper examines the Friedman-Phelps‘expectational (dis)equilibrium’ and the Clower-Leijonhufvud‘non-market-clearing’ paradigms as alternative disequilibrium theories, and draws their respective policy implications. Then, these paradigms are taken as complementary to each other, as containing necessary ingredients for a synthetic disequilibrium theory, whose policy implications can only tentatively be explored. A general disequilibrium theory is founded on the notion of ‘disequilibrium consciousness’ and on a detailed characterization of ‘conjectural’ price and/or quantity responses to non-market-clearing, whose quasi-equilibrium outcome is conditioned by both expectations and the intra-market spillover effect.

Notes: The paper identifies the disturbances in the balance of payments of the non-oil less developed countries responsible for the rapid growth in their external debt between 1972 and 1977. It also examines prospects for the future. It finds that the sharp growth in the current account deficits in the years 1974 and 1975 was due primarily to adverse movements in the terms of trade. But trade terms were reversed in 1976 and 1977 and the deficit was reduced. Still overall inflation, slow export growth, and large interest payments kept the deficit substantially above the 1972 and earlier levels. In part II the paper examines how the debt to GNP ratio of the LDC's could be affected by four factors: export growth, changes in real interest rates, terms of trade, and credit rationing. A model is developed which shows that certain combinations of the four factors could lead to rapid accumulation of debt relative to GNP.

Notes: The paper studies the impact on international capital movements of the accelerated tax depreciation scheme introduced in the U. S. A. under the REAGAN administration. It is argued on theoretical grounds that, contrary to most other potential tax reforms, this depreciation scheme calls for a substantial restructuring in the world-wide capital stock in favor of the U. S. Moreover, it is demonstrated that the scheme may induce severe sectoral changes within national economies. Countries that do not take countervailing actions against the U. S. policy are likely to experience a rise in their labour intensive industries at the expense of losing their capital intensive industries. A tentative estimate based on stylized economic facts indicates the necessity of a capital import into the U. S. of at least 7% of the OECD capital stock, which means that even with a doubling of the 1983 U. S. current account deficit of $40 billion more than a decade would have to pass in order for the required structural changes to be accomplished.

Notes: The growing leniency and generosity of public income support systems has been hypothesized to negatively affect work effort. The magnitude of this effect is estimated for the U. S. and the Netherlands in the 1970s, using a three-stage Probit-OLS model employed on micro data sets. Individuals are viewed as choosing the number of hours worked on the basis of expected labor income, expected transfer income, labor market and demographic characteristics and health. The elasticity of annual hours worked with respect to expected transfer income was estimated to be -0.22 for U. S. and -0.82 (1980) for the Netherlands. Combining these elasticities with the annual percentage increases in transfer generosity yields a yearly reduction in the number of hours worked of 0.65% for the U. S. and 2.7% for the Netherlands during the 1970s. These results suggest that growing transfers have had a substantial and negative impact on desired work effort and thus on production and economic performance, especially in the Netherlands.