ISSN:
1744-313X
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Biology
,
Medicine
Notes:
H-2 typing of two inbred mouse strains, GRS I/A and LIS/A, revealed that they both carry the same, previously unknown haplotype, designated H-2dx. The H-2dx haplotype has the K region allele identical or very similar to that of H-2d, however it differs from H-2d at the I region genes and has none of the D region alleles previously described in inbred mouse strains.When the H-2dx haplotype was used in F1 complementation tests, it failed to prevent rejection of B10.D2 skin grafts by (GR × B10.A)F1 and (LI × B10.A)F1 recipients, as well as rejection of R103 grafts by (GR × 2R)F1, (LI × 2R)F1, (GR × B10)F1, and (LI × B10)F1 recipients. In all these combinations, the donor and the recipients were matched at the K and D regions, but differed at the I region. The mean rejection time was 12 days (beginning) and 15.9 days (end of rejection).The second set skin grafts were rejected at approximately the same speed as the first set skin grafts, and after their rejection a cytotoxic antibody, most likely anti-Ia, was found in the serum of the recipient mice. The absence of accelerated second set skin graft rejection in the I region incompatibility observed in these experiments is in sharp contrast to the extremely fast rejection of K or D region incompatible second set skin grafts. This lack of demonstrable anamnestic response is either due to the presence of enhancing antibodies, or to an inherently inferior capacity of I region incompatibility to elicit, in vivo, an effective anamnestic response.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1744-313X.1975.tb00542.x
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