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  • General Chemistry  (6,647)
  • Atomic, Molecular and Optical Physics  (1,119)
  • Biochemistry  (522)
  • Herkomst
  • Humans
  • Wiley-Blackwell  (8,285)
  • Springer  (6)
  • 1985-1989  (6,728)
  • 1940-1944  (1,563)
Collection
Keywords
Publisher
Years
Year
  • 1
    Electronic Resource
    Electronic Resource
    The compositional distribution of coding sequences and DNA molecules in humans and murids (1988)
    Springer
    Journal of molecular evolution 27 (1988), S. 311-320 
    Details
    ISSN: 1432-1432
    Keywords: Genome composition ; Coding sequences ; Isochores ; Humans ; Murids
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The compositional distributions of coding sequences and DNA molecules (in the 50-100-kb range) are remarkably narrower in murids (rat and mouse) compared to humans (as well as to all other mammals explored so far). In murids, both distributions begin at higher and end at lower GC values. A comparison of homologous coding sequences from murids and humans revealed that their different compositional distributions are due to differences in GC levels in all three codon positions, particularly of genes located at both ends of the distribution. In turn, these differences are responsible for differences in both codon usage and amino acids. When GC levels at first+second codon positions and third codon positions, respectively, of murid genes are plotted against corresponding GC levels of homologous human genes, linear relationships (with very high correlation coefficients and slopes of about 0.78 and 0.60, respectively) are found. This indicates a conservation of the order of GC levels in homologous genes from humans and murids. (The same comparison for mouse and rat genes indicates a conservation of GC levels of homologous genes.) A similar linear relationship was observed when plotting GC levels of corresponding DNA fractions (as obtained by density gradient centrifugation in the presence of a sequence-specific ligand) from mouse and human. These findings indicate that orderly compositional changes affecting not only coding sequences but also noncoding sequences took place since the divergence of murids. Such directional fixations of mutations point to the existence of selective pressures affecting the genome as a whole.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02101193
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  • 2
    Electronic Resource
    Electronic Resource
    Implementation of periodic acid-thiosemicarbazide-silver proteinate staining for ultrastructural assessment of muscle glycogen utilization during exercise (1985)
    Springer
    Cell & tissue research 242 (1985), S. 229-232 
    Details
    ISSN: 1432-0878
    Keywords: Skeletal muscles ; Ultrastructure ; Exercise ; Glycogen ; Humans
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Distribution of glycogen particles in semithin and ultrathin sections of biopsy samples from human muscles subjected to either short- or long-term running were investigated using PAS and Periodic Acid-ThioSemiCarbazide-Silver Proteinate (PA-TSC-SP) staining methods. Glycogen particles were predominantly found immediately under the sarcolemma or aligned along the myofibrillar Iband. After long-term exhaustive exercise type-1 fibers with a few or no glycogen particles in the core of the fibers were frequently observed. The subsarcolemmal glycogen stores of these “depleted” type-1 fibers were about three times as large as after exhaustive short-time exercise. Another indication of utilization of subsarcolemmal glycogen stores during anaerobic exercise was that many particles displayed a pale, rudimentary shape. This observation suggests fragmental metabolization of glycogen. Thus, depending on type of exercise and type of fiber differential and sequential glycogen utilization patterns can be observed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00225582
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  • 3
    Electronic Resource
    Electronic Resource
    Histamine receptors in the central nervous system (1989)
    Springer
    Pharmacy world & science 11 (1989), S. 146-150 
    Details
    ISSN: 1573-739X
    Keywords: Agonists ; Antagonists ; Biochemistry ; Central nervous system ; Ligands ; Pharmacology ; Receptors, histamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The role of histamine in brain function is discussed. A brief review is presented on the three types of histamine receptors with regard to their biochemistry and functions, as well as on specific ligands, both agonists and antagonists. It is concluded that several aspects of the pharmacology of histamine in the central nervous system are still a matter of empirism and speculations. The recent publications on the brain-penetrating H2 antagonist zolantidine and the selective H3 agonists and antagonists are expected to contribute to the knowledge of the histaminergic pathways in the brain. Therapeutical areas within the central nervous system are related to behaviour (including wake-sleep), neuroendocrinal processes, the control of muscle activity and cerebral circulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01959461
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  • 4
    Electronic Resource
    Electronic Resource
    Pharmacochemical aspects of leprosy (1989)
    Springer
    Pharmacy world & science 11 (1989), S. 3-8 
    Details
    ISSN: 1573-739X
    Keywords: Biochemistry ; Clofazimine ; Dapsone ; Ethionamide ; Isoniazide ; Mechanism of action ; Mycobacterium leprae ; Prothionamide ; Quinolones ; Ribonucleotide reductase inhibitors ; Rifampicin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract From a pharmacochemical point of view the existing anti-leprotics as well as possible innovations in the chemotherapy of leprosy are discussed. Of the main anti-leprotics, which are used nowadays — dapsone, rifampicin, clofazimine, isoniazide, ethionamide and prothionamide — the mechanism of action, the main problems in their application and possibilities to develop improved variants are reviewed. Based on the chemistry ofMycobacterium leprae, the target systems for new anti-leprotics are identified. These systems include the cell wall, the catabolism of reactive oxygen species, the metabolisms of carbon sources, the amino acid metabolism and the uptake of iron. Two possible new lead structures from other fields, 4-quinolones and mycobacterial ribonucleotide reductase inhibitors are presented.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01972907
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  • 5
    Electronic Resource
    Electronic Resource
    The beta-adrenoceptor-adenylate cyclase complex (1986)
    Springer
    Pharmacy world & science 8 (1986), S. 209-222 
    Details
    ISSN: 1573-739X
    Keywords: Biochemistry ; Pharmacology ; Receptors, adrenergic, beta ; Review
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Developments in the receptor concept have greatly influenced our current knowledge of the beta-adrenoceptor. The triad of pharmacology, organic chemistry and studies in structure-activity relationships is discussed along historical lines, as it has been and still is an impetus for progress in the biochemistry of ligand-receptor interactions. With respect to the beta-adrenoceptor complex these advances which have led to a model in which three protein structures are functionally interacting within the frame of the cell wall: the beta-adrenoceptor, the regulatory guanine nucleotide binding protein, and the enzyme adenylate cyclase, are reviewed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01957781
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  • 6
    Electronic Resource
    Electronic Resource
    Onderzoekingen over stuifbrand (1944)
    Springer
    European journal of plant pathology 50 (1944), S. 73-106 
    Details
    ISSN: 1573-8469
    Keywords: Dwerg ; Gemiddelde ; Gewas ; „Gezond” ; Graad van aantasting ; Herkomst ; Herstel ; Kieming ; Kiemplant ; Klein ; Overgevoelig ; Physio ; Ras ; Rijping ; Stuifbrand ; Vatbaar ; Volwassen plant ; „Ziek” ; dwarf ; mean ; crop ; in relation to seedlings: normal ; degree of attack ; origin ; recovering ; germination ; seedling ; small ; hypersensitive ; physiologic race ; variety ; maturation ; smut ; susceptible ; mature plant ; in relation to seedlings: abnormal
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02056007
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  • 7
    Electronic Resource
    Electronic Resource
    Warped linear analytic tetrahedral scheme for brillouin zone integrations (1985)
    New York, NY : Wiley-Blackwell
    International Journal of Quantum Chemistry 27 (1985), S. 97-101 
    Details
    ISSN: 0020-7608
    Keywords: Computational Chemistry and Molecular Modeling ; Atomic, Molecular and Optical Physics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: We provide an alternative to the biquadratic analytic scheme BIQ published earlier. This form, AMPLIN, is similar to the older linear analytic scheme, LIN. This scheme is much faster than BIQ.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/qua.560270108
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  • 8
    Electronic Resource
    Electronic Resource
    Announcement (1985)
    New York, NY : Wiley-Blackwell
    International Journal of Quantum Chemistry 27 (1985), S. 105-105 
    Details
    ISSN: 0020-7608
    Keywords: Computational Chemistry and Molecular Modeling ; Atomic, Molecular and Optical Physics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/qua.560270110
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  • 9
    Electronic Resource
    Electronic Resource
    Isoscalar factors for tetragonal, orthorhombic, monoclinic and triclinic shubnikov point groups (1985)
    New York, NY : Wiley-Blackwell
    International Journal of Quantum Chemistry 27 (1985), S. 45-58 
    Details
    ISSN: 0020-7608
    Keywords: Computational Chemistry and Molecular Modeling ; Atomic, Molecular and Optical Physics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The relations between isoscalar factors for corepresentations of antiunitary magnetic point groups are discussed in the case of associated corepresentations. The tables of the isoscalar factors for the single- and double-valued corepresentations of all tetragonal, orthorhombic, monoclinic, and triclinic Shubnikov point groups are given. Some peculiarities of the calculation method of the isoscalar factors for corepresentations are considered.
    Additional Material: 10 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/qua.560270104
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  • 10
    Electronic Resource
    Electronic Resource
    Symmetrization of operator matrix elements (1985)
    New York, NY : Wiley-Blackwell
    International Journal of Quantum Chemistry 27 (1985), S. 89-96 
    Details
    ISSN: 0020-7608
    Keywords: Computational Chemistry and Molecular Modeling ; Atomic, Molecular and Optical Physics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The method of Dupuis and King for generating matrix elements of a totally symmetric one-electron operator in terms of symmetry-distinct integrals only is generalized to the case of nontotally symmetric operators. For operators constructed from two-electron integrals, explicit reduction of integral processing to permutationally inequivalent symmetry-distinct integrals only is described, while for one-electron operators further reductions are derived using double coset decompositions. Finally, some computational consequences of this approach are briefly discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/qua.560270107
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