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  • Articles  (50,098)
  • Springer  (50,098)
  • 1985-1989  (45,166)
  • 1950-1954  (4,932)
  • Mathematics  (30,460)
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  • Articles  (50,098)
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  • 1
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    Bulletin of mathematical biology 51 (1989), S. 223-246 
    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract We present a new symmetric model of the idiotypic immune network. The model specifies clones of B-lymphocytes and incorporates: (1) influx and decay of cells; (2) symmetric stimulatory and inhibitory idiotypic interactions; (3) an explicit affinity parameter (matrix); (4) external (i.e. non-idiotypic) antigens. Suppression is the dominant interaction, i.e. strong idiotypic interactions are always suppressive. This precludes reciprocal stimulation of large clones and thus infinite proliferation. Idiotypic interactions first evoke proliferation, this enlarges the clones, and may in turn evoke suppression. We investigate the effect of idiotypic interactions on normal proliferative immune responses to antigens (e.g. viruses). A 2-D, i.e. two clone, network has a maximum of three stable equilibria: the virgin state and two asymmetric immune states. The immune states only exist if the affinity of the idiotypic interaction is high enough. Stimulation with antigen leads to a switch from the virgin state to the corresponding immune state. The network therefore remembers antigens, i.e. it accounts for immunity/memory by switching beteen multiple stable states. 3-D systems have, depending on the affinities, 9 qualitatively different states. Most of these also account for memory by state switching. Our idiotypic network however fails to account for the control of proliferation, e.g. suppression of excessive proliferation. In symmetric networks, the proliferating clones suppress their anti-idiotypic suppressors long before the latter can suppress the former. The absence of proliferation control violates the general assumption that idiotypic interactions play an important role in immune regulation. We therefore test the robustness of these results by abandoning our assumption that proliferation occurs before suppression. We thus define an “escape from suppression” model, i.e. in the “virgin” state idiotypic interactions are now suppressive. This system erratically accounts for memory and never for suppression. We conclude that our “absence of suppression from idiotypic interactions” does not hinge upon our “proliferation before suppression” assumption.
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  • 2
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    Bulletin of mathematical biology 51 (1989), S. 287-291 
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  • 3
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    Bulletin of mathematical biology 51 (1989), S. I 
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  • 4
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    Bulletin of mathematical biology 51 (1989), S. 325-335 
    ISSN: 1522-9602
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    Notes: Abstract Analytical bounding functions for diffusion problems with Michaelis-Menten kinetics were recently presented by Anderson and Arthurs, 1985 (Bull. math. Biol. 47, 145–153). Their methods, successful to some extent for a small range of parameters, has the disadvantage of providing a weak upper bound. The optimal approach for the use of one-line bounding kinetics is presented. The use of two-line bounding kinetics is also shown, in order to give, sufficient accuracy in those cases where the one-line approach does not provide satisfactory results. The bounding functions provide excellent upper and lower bounds on the true solution for the entire range of kinetic and transport parameters.
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  • 5
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    Bulletin of mathematical biology 51 (1989), S. 311-323 
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    Notes: Abstract Thresholds for survival and extinction are important for assessing the risk of mortality in systems exposed to exogeneous stress. For generic, rudimentary population models and the classical resource-consumer models of Leslie and Gallopin, we demonstrate the existence of a survival threshold for situations where demographic parameters are fluctuating, generally, in a nonperiodic manner. The fluctuations are assumed, to be generated by exogenous, anthropogenic stresses such as toxic chemical exposures. In general, the survival threshold is determined by a relationship between mean stress measure in organisms to the ratio of the population intrinsic growth rate and stress response rate.
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  • 6
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    Bulletin of mathematical biology 51 (1989), S. 409-411 
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  • 7
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    Bulletin of mathematical biology 51 (1989), S. 415-415 
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  • 8
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    Bulletin of mathematical biology 51 (1989), S. 731-747 
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    Notes: Abstract A stochastic analog to a deterministic model describing subpopulation emergence in heterogeneous tumors is developed. The resulting system is described by the Fokker-Planck or forward Kolmogorov equation. A finite element approach for the numerical solution to this equation is described. Four biological and clinical scenarios are simulated (emergence of heterogeneity, exclusion of a subpopulation, and induction of drug resistance in both pure and heterogeneous tumors). The results of the simulations show that the stochastic model describes the same basic dynamics as its deterministic counterpart via a convective component, but that for each simulation a distribution of tumor sizes and mixes can also be derived from a diffusive component in the model. These distributions yield estimates for subpopulation extinction probabilities. The biological and clinical relevance of these results are discussed.
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  • 9
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    Bulletin of mathematical biology 51 (1989), S. 39-54 
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    Notes: Abstract Two algorithms for the efficient identification of segment neighborhoods are presented. A segment neighborhood is a set of contiguous residues that share common features. Two procedures are developed to efficiently find estimates for the parameters of the model that describe these features and for the residues that define the boundaries of each segment neighborhood. The algorithms can accept nearly any model of segment neighborhood, and can be applied with a broad class of best fit functions including least squares and maximum likelihood. The algorithms successively identify the most important features of the sequence. The application of one of these methods to the haemagglutinin protein of influenza virus reveals a possible mechanism for conformational change through the finding of a break in a strong heptad repeat structure.
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  • 10
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    Bulletin of mathematical biology 51 (1989), S. 5-37 
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    Notes: Abstract Given a sequenceA and regular expressionR, theapproximate regular expression matching problem is to find a sequence matchingR whose optimal alignment withA is the highest scoring of all such sequences. This paper develops an algorithm to solve the problem in timeO(MN), whereM andN are the lengths ofA andR. Thus, the time requirement is asymptotically no worse than for the simpler problem of aligning two fixed sequences. Our method is superior to an earlier algorithm by Wagner and Seiferas in several ways. First, it treats real-valued costs, in addition to integer costs, with no loss of asymptotic efficiency. Second, it requires onlyO(N) space to deliver just the score of the best alignment. Finally, its structure permits implementation techniques that make it extremely fast in practice. We extend the method to accommodate gap penalties, as required for typical applications in molecular biology, and further refine it to search for substrings ofA that strongly align with a sequence inR, as required for typical data base searches. We also show how to deliver an optimal alignment betweenA andR in onlyO(N+logM) space usingO(MN logM) time. Finally, anO(MN(M+N)+N 2logN) time algorithm is presented for alignment scoring schemes where the cost of a gap is an arbitrary increasing function of its length.
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  • 11
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    Bulletin of mathematical biology 51 (1989), S. 95-115 
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    Notes: Abstract The stochastic complexity of a data base of 365 protein-coding regions is analysed. When the primary sequence is modeled as a spatially homogeneous Markov source, the fit to observed codon preference is very poor. The situation improves substantially when a non-homogeneous model is used. Some implications for the estimation of species phylogeny and substitution rates are discussed.
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  • 12
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    Bulletin of mathematical biology 51 (1989), S. 125-131 
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    Notes: Abstract We present, in an easy to use form, the large deviation theory of the binomial distribution: how to approximate the probability ofk or more successes inn independent trials, each with success probabilityp, when the specified fraction of successes,a≡k/n, satisfies 0〈p〈a〈1.
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  • 13
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    Bulletin of mathematical biology 51 (1989), S. I 
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  • 14
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    Bulletin of mathematical biology 51 (1989), S. 167-171 
    ISSN: 1522-9602
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    Notes: Abstract A linear segment in which a number of pairs of intervals of equal length are identified as potential stems is the subject of a folding problem analogous to inference of RNA secondary structure. A quantity of free energy (or equivalently, energy per unit length) is associated with each stem, and the various types of loops are assigned energy costs as a function of their lengths. Inference of stable structures can then be carried out in the same way as in RNA folding. More important, perturbation of stem lengths and energy densities (modelling various mutational processes affecting nucleotide sequences) allows the delineation of domains of stability of various foldings, through the explicit calculation of their boundaries, in a low-dimensional parameter space.
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  • 15
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    Bulletin of mathematical biology 51 (1989), S. 337-346 
    ISSN: 1522-9602
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    Notes: Abstract In sensory physiology, various System Identification methods are implemented to formalized stimulus-response relationships. We applied the Volterra approach for characterizing input-output relationships of cells in the medial geniculate body (MGB) of an awake squirrel monkey. Intraspecific communication calls comprised the inputs and the corresponding cellular evoked responses—the outputs. A set of vocalization was used to calculate the kernels of the transformation, and these kernels subserved to predict the responses of the cell to a different set of vocalizations. It was found that it is possible to predict the response (PSTH) of MGB cells to natural vocalizations, based on envelopes of the spectral components of the vocalization. Some of the responses could be predicted by assuming a linear transformation function, whereas other responses could be predicted by non-linear (second order) kernels. These two modes of transformation, which are also reflected by a distinct spatial distribution of the linearvis-à-vis non-linear responding cells, apparently representa new revelation of parallel processing of auditory information.
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  • 16
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    Bulletin of mathematical biology 51 (1989), S. 359-379 
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    Notes: Abstract The time-dependent surface coverage of antigen-antibody complexes for a sensor in which antigens are bound to surface immobilized antibodies is determined analytically. Assuming a reversible first order reaction between the antigens and antibodies, a model is derived describing the dynamical response of the sensor. The surface coverage is related explicitly to the antigen concentration which is of special interest in experimental situations. The stationary state and short time behaviour are determined explicitly. Several illustrations of the full solution are provided.
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  • 17
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    Bulletin of mathematical biology 51 (1989), S. 347-358 
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    Notes: Abstract Simple reaction time is the minimum time required to respond to a signal such as a steady light or tone. Such a reaction time is taken to be the time required for transmission of a fixed quantity of information, ΔH, from stimulus to subject. That is, information summation replaces energy summation. This information is calculated from consideration of the quantum nature of the stimulus. The theoretically derived equation for reaction time is fitted to experimental data. Piéron's empirical law for reaction time is obtained as an approximation from a proposed informational equation. The exponent in Piéron's law is found to be the same as the exponent in the power law of sensation. Threshold appears to be the smallest stimulus capable of transmitting the quantity of information ΔH.
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  • 18
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    Bulletin of mathematical biology 51 (1989), S. 413-413 
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  • 19
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    Bulletin of mathematical biology 51 (1989), S. I 
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  • 20
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    Bulletin of mathematical biology 51 (1989), S. 55-78 
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    Notes: Abstract This article extends the use of dynamic programming algorithms in molecular sequence comparison to the alignment of the α-carbon (Cα-) coordinates of two protein structures in three dimensions. The algorithm is described in detail and is applied to the comparison of α-lactalbumin with both hen egg white lysozyme and T4 lysozyme. In the first case, the structures are similar, while the second comparison is between two distantly related molecules. References are made to the usual sequence alignments. A variety of complementary methods are introduced to display the results.
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  • 21
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    Bulletin of mathematical biology 51 (1989), S. 79-94 
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    Notes: Abstract The composition of naturally occurring DNA sequences is often strikingly heterogeneous. In this paper, the DNA sequence is viewed as a stochastic process with local compositional properties determined by the states of a hidden Markov chain. The model used is a discrete-state, discreteoutcome version of a general model for non-stationary time series proposed by Kitagawa (1987). A smoothing algorithm is described which can be used to reconstruct the hidden process and produce graphic displays of the compositional structure of a sequence. The problem of parameter estimation is approached using likelihood methods and an EM algorithm for approximating the maximum likelihood estimate is derived. The methods are applied to sequences from yeast mitochondrial DNA, human and mouse mitochondrial DNAs, a human X chromosomal fragment and the complete genome of bacteriophage lambda.
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  • 22
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    Bulletin of mathematical biology 51 (1989), S. 133-166 
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    Notes: Abstract A new and apparently rather useful and natural concept in cluster analysis is studied: given a similarity measure on a set of objects, a sub-set is regarded as a cluster if any two objectsa, b inside this sub-set have greater similarity than any third object outside has to at least one ofa, b. These clusters then form a closure system which can be described as a hypergraph without triangles. Conversely, given such a system, one may attach some weight to each cluster and then compose a similarity measure additively, by letting the similarity of a pair be the sum of weights of the clusters containing that particular pair. The original clusters can be reconstructed from the obtained similarity measure. This clustering model is thus located between the general additive clustering model of Shepard and Arabie (1979) and the standard hierarchical model. Potential applications include fitting dendrograms with few additional nonnested clusters and simultaneous representation of some families of multiple dendrograms (in particular, two-dendrogram solutions), as well as assisting the search for phylogenetic relationships by proposing a somewhat larger system of possibly relevant “family groups”, from which an appropriate choice (based on additional insight or individual preferences) remains to be made.
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  • 23
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    Bulletin of mathematical biology 51 (1989), S. 173-194 
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    Notes: Abstract An important component of computer programs for determining the solution conformation of proteins and other flexible molecules from nuclear magnetic resonance data are the so-called “bound smoothing algorithms”, which compute lower and upper limits on the values of all the interatomic distances from the relatively sparse set which can usually be measured experimentally. To date, the only methods efficient enough for use in large problems take account of only the triangle inequality, but an appreciable improvement in the precision of the limits is possible if the algebraic relations between the distances among each quadruple of atoms are also considered. The goal of this paper is to use a recently improved algorithm for computing these “tetrangle inequality limits” to determine just how much improvement really is possible, given the types of experimental data that are usually available.
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  • 24
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    Bulletin of mathematical biology 51 (1989), S. 207-216 
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    Notes: Abstract We apply the concept of marginal stability hypothesis, which has been proposed for solving the problem of dendritic crystal growth, to the pattern selection problem in the Gierer-Meinhardt models. In the case of a large system, the system selects a definite wavelength of the ultimate spatial pattern when the unstable homogeneous steady state is locally disturbed. The numerical results are analyzed theoretically by means of the marginal stability hypothesis, and they are in good agreement with it. Biologically, these results imply why for large systems the Gierer-Meinhardt model (and presumably other reaction-diffusion schemes) have the ability to explain the observation that pattern-generating mechanisms are remarkably insensitive to a wide range of environmental and experimental conditions.
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  • 25
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    Bulletin of mathematical biology 51 (1989), S. 247-253 
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    Notes: Abstract Small networks of threshold automata are used to model complex interactions between populations of regulatory cells (helpers and suppressors, antigen specific and anti-idiotypic) which participate in the immune response. The models, being discrete and semiquantitative, are well adapted to the situation of incomplete information often encounteredin vivo. However, the dynamics of many different network structures usually end up in the same attractor set. Thus, many different theories are equivalent in their explicative power for the same facts. This property, known as underdetermination of the theories by the facts, is given a quantitative estimate. It appears that such an underdetermination, as a kind of irreductible complexity, can be expected in manyin vivo biological processes, even when the number of interacting and functionally coupled elements is relatively small.
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  • 26
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    Bulletin of mathematical biology 51 (1989), S. 501-510 
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    Notes: Abstract The “paradox of enrichment” predicts that increasing the growth rate of the resource in a resource-consumer dynamic system, by nutrient enrichment, for example, can lead to local instability of the system—that is, to a Hopf bifurcation. The approach to the Hopf bifurcation is accompanied by a decrease in resilience (rate of return to equilibrium). On the other hand, studies of nutrient cycling in food webs indicate that an increase in the nutrient input rate usually results in increased resilience. Here these two apparently conflicting theoretical results are reconciled with a model of a nutrient-limited resource-consumer system in which the tightly recycled limiting nutrient is explicitly modelled. It is shown that increasing nutrient input may at first lead to increased resilience and that resilience decreases sharply only immediately before the Hopf bifurcation is reached.
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  • 27
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    Bulletin of mathematical biology 51 (1989), S. 537-544 
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  • 28
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    Bulletin of mathematical biology 51 (1989), S. 511-536 
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    Notes: Abstract Statistical properties of topological binary trees are studied on the basis of the distribution of segments in relation to centrifugal order. Special attention is paid to the mean of this distribution in a tree as it will be used as a measure of tree topology. It will be shown how the expectation of the mean centrifugal order depends both on the size of the tree and on the mode of growth in the context of modelling the growth of tree structures. Observed trees can be characterized by their mean orders and procedures are described to find the growth mode that optimally corresponds to these data. The variance structure of the mean-order measure appears to be a crucial factor in these fitting procedures. Examples indicate that mean-order analysis is an accurate alternative to partition analysis that is based on the partitioning of segments over sub-tree pairs at branching points.
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  • 29
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    Bulletin of mathematical biology 51 (1989), S. 681-686 
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    Notes: Abstract We propose certain general conditions that we believe are reasonable for any pattern recognition algorithm. We find that these conditions give rise to paradoxical identification. The algorithms are incapable of distinguishing composite patterns and must be able to distinguish patterns at an atomistic level.
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    Bulletin of mathematical biology 51 (1989), S. 657-679 
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    Notes: Abstract A stratigraphically oriented series of the Miocene foraminiferal speciesBrizalina mandoroveensis from Ikang, Cameroon, was analyzed both by conventional multivariate morphometric procedures and by the tensor biometric method of Bookstein (1986;Statist. Sci. 1, 181–142), a method which analyzes sets of landmark points rather than specific variables of shape or size. The conventional analysis used five size-measures upon 170 specimens from five stratigraphic levels; the tensor analysis encompassed six landmarks (12 coordinates) upon 50 specimens. Whereas certain features appeared in both analyses, such as the separation between levels one and five, the techniques did not always agree with respect to the interpretation of those findings or about most details in the sequence of mean phenotypes. The canonical variate analysis bases its ordination upon a general size factor (the meaning of which is obscured by the foreshortening of within-group variation which is built into the technique). The tensor analysis locates a similar ordination using mainly features of shape.
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    Bulletin of mathematical biology 51 (1989), S. 715-730 
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    Notes: Abstract In a separate paper, we developed a mathematical model describing HIV infection and used it to suggest experiments for quantifying characteristic viral parameters. In this paper we generalize the model to any well-mixed assay system. We also present complete and rigorous derivations of fundamental results needed for the design and analysis of HIV infectivity assays. The model is applicable to infectious agents with multiple receptors for their target cell (e.g. HIV, Epstein-Barr virus and Plasmodium), and to blockers (both reversible and irreversible), as long as blocker and target cells are the same diffusion compartment.
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    Bulletin of mathematical biology 51 (1989), S. 687-713 
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    Notes: Abstract A general version of a model of Ebenman for the dynamics of a population consisting of competing juveniles and adults is analyzed using methods of bifurcation theory. A very general existence results is obtained for non-trivial equilibria and non-negative synchronous two-cycles that bifurcate simultaneously at the critical valuer=1 of the inherent net reproductive rater. Stability is studied in this general setting near the bifurcation point and conditions are derived that determine which of these two bifurcating branches is the stable branch. These general results are supplemented by numerical studies of the asymptotic dynamics over wider parameter ranges where various other bifurcations and stable attractors are found. The implications of these results are discussed with respect to the effects on stability that age class competition within a population can have and whether such competition is stabilizing or destabilizing.
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    Bulletin of mathematical biology 51 (1989), S. 749-784 
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    Notes: Abstract Phototransduction is a process which links the absorption of photons by a rod or cone to the modulation of voltage across the cell membrane. An important feature of many vertebrate photoreceptors is a mechanism that adjusts the sensitivity and dynamics of the response to light according to the level of illumination. We construct a system of ordinary differential equations that models what are currently thought to be the important molecule mechanisms involved in phototransduction: this includes consideration of both intracellular enzyme kinetics and the properties of light-insensitive and light-sensitive conductances in the cone membrane. The system contains negative feedback whose functional form is determined by constraining the steady-state behaviour of the system. Despite the highly nonlinear nature of the system of ordinary differential equations, our methods permit us to derive an analytic expression for the first-order frequency response parametric in the steady-state value of only one dynamic variable, the light input. Various unknown kinetic parameters are found by fitting the model to experimental data on the first-order frequency response of cones measured at several mean light levels spanning a range of four log units. Good fits are obtained to the data, and the computed shape of the feedback function agrees qualitatively with recent experiment. Moreover, the model accounts for the dramatic speeding up of the response kinetics and the decrease in response gain with increasing light level.
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    Bulletin of mathematical biology 51 (1989), S. 1-4 
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    Bulletin of mathematical biology 51 (1989), S. 381-408 
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    Notes: Abstract We first analyse a simple symmetric model of the idiotypic network. In the model idiotypic interactions regulate B cell proliferation. Three non-idiotypic processes are incorporated: (1) influx of newborn cells; (2) turnover of cells: (3) antigen. Antigen also regulates proliferation. A model of 2 B cell populations has 3 stable equilibria: one virgin, two immune. The twodimensional system thus remembers antigens, i.e. accounts for immunity. By contrast, if an idiotypic clone proliferates (in response to antigen), its anti-idiotypic partner is unable to control this. Symmetric idiotypic networks thus fail to account for proliferation regulation. In high-D networks we run into two problems. Firstly, if the network accounts for memory, idiotypic activation always propagates very deeply into the network. This is very unrealistic, but is an implication of the “realistic” assumption that it should be easier to activate all cells of a small virgin clone than to maintain the activation of all cells of a large (immune) clone. Secondly, graph theory teaches us that if the (random) network connectance exceeds a threshold level of one interaction per clone, most clones are interconnected. We show that this theory is also applicable to immune networks based on complementary matching idiotypes. The combination of the first “percolation” result with the “interconnectancr” result means that the first stimulation of the network with antigen should eventually affect most of the clones. We think this is unreasonable. Another threshold property of the network connectivity is the existence of a virgin state. A gradual increase in network connectance eliminates the virgin state and thus causes an abrupt change in network behaviour. In contrast to weakly connected systems, highly connected networks display autonomous activity and are unresponsive to external antigens. Similar differences between neonatal and adult networks have been described by experimentalists. The robustness of these results is tested with a network in which idiotypic inactivation of a clone occurs more generally than activation. Such “long-range inhibition” is known to promote pattern formation. However, in our model it fails to reduce the percolation, and additionally, generates semi-chaotic behaviour. In our network, the inhibition of a clone that is inhibiting can alter this clone into a clone that is activating. Hence “long-range inhibition” implies “long-range activation”, and idiotypic activation fails to remain localized. We next complicate this model by incorporating antibody production. Although this “antibody” model statically accounts for the same set of equilibrium points, it dynamically fails to account for state switching (i.e. memory). The switching behaviour is disturbed by the autonomous slow decay of the (long-lived) antibodies. After antigenic triggering the system now performs complex cyclic behaviour. Finally, it is suggested that (idiotypic) formation of antibody complexes can play only a secondary role in the network. In conclusion, our results cast doubt on the functional role of a profound idiotypic network. The network fails to account for proliferation regulation, and if it accounts for memory phenomena, it “explodes” upon the first encounter with antigen due to extensive percolation.
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    Bulletin of mathematical biology 51 (1989), S. 433-447 
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    Notes: Abstract A new biomathematical description is given for the shape of the birch leaf roller's (Deporaus betulae) incisions. These incisions are investigated for different leaves. The theoretical patterns agree well with the real ones, and the presented mathematical expressions describe well the shape of the real incisions.
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    Bulletin of mathematical biology 51 (1989), S. 417-432 
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    Notes: Abstract Nucleotide sequences carry genetic information of many different kinds, not just instructions for protein synthesis (triplet code). Several codes of nucleotide sequences are discussed including: (1) the translation framing code, responsible for correct triplet counting by the ribosome during protein synthesis; (2) the chromatin code, which provides instructions on appropriate placement of nucleosomes along the DNA molecules and their spatial arrangement; (3) a putative loop code for single-stranded RNA-protein interactions. The codes are degenerate and corresponding messages are not only interspersed but actually overlap, so that some nucleotides belong to several messages simultaneously. Tandemly repeated sequences frequently considered as functionless “junk” are found to be grouped into certain classes of repeat unit lengths. This indicates some functional involvement of these sequences. A hypothesis is formulated according to which the tandem repeats are given the role of weak enhancer-silencers that modulate, in a copy number-dependent way, the expression of proximal genes. Fast amplification and elimination of the repeats provides an attractive mechanism of species adaptation to a rapidly changing environment.
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    Bulletin of mathematical biology 51 (1989), S. 449-465 
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    Notes: Abstract The kinematics of an area-conserving tank-treading disk-shaped red blood cell membrane is studied using the stream function method suggested by Secomb and Skalak (Q. Jl Mech. appl. Math. 35, Pt 2, 233–247, 1982). Two simple area-conserving velocity fields are superimposed to satisfy the continuity condition at the curved edges of the disk. A differential equation for the trajectory of any material point of the membrane is derived. The requirement of synchrony of the cycle for all membrane points leads to an integral equation which determines a magnitude function. An approximate solution is made possible by assuming small trajectory deflections.
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    Bulletin of mathematical biology 51 (1989), S. 467-474 
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    Notes: Abstract The probability of becoming infected with HIV is formulated in terms of the total number of sexual contacts (N), the probability that a sexual act is infectious (r) and the prevalence (p). Using the appropriate equations we studied the effect of reducing each of the risk factors on lowering the probability of infection. We show that for many realistic situations the probability of becoming infected by multiple partners is equal to the probability of becoming infected by one partner in a monogamous relationship given that the prevalence is the same in both cases; however if the multiple partners are chosen over time from a pool of a growing prevalence, then one is better off in a monogamous relationship where that partner is chosen early in the epidemic.
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    Bulletin of mathematical biology 51 (1989), S. 597-603 
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    Notes: Abstract In this article the question of reconstructing a phylogeny from additive distance data is addressed. Previous algorithms used the complete distance matrix of then OTUs (Operational Taxonomic Unit), that corresponds to the tips of the tree. This usedO(n 2) computing time. It is shown that this is wasteful for biologically reasonable trees. If the tree has internal nodes with degrees that are bounded onO(n*log(n)) algorithm is possible. It is also shown if the nodes can have unbounded degrees the problem hasn 2 as lower bound.
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    Bulletin of mathematical biology 51 (1989), S. I 
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    Bulletin of mathematical biology 51 (1989), S. 785-800 
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    Notes: Abstract In this paper we analyse time series data as the growth of organisms using markers such as treerings and otolith deposits (fish). The series studied belong to two tree species (Pinus uncinata, Fagus sylvatica) and one fish species (Dicentrarchus labrax). Spectral analyses of the time series growth show that the main frequencies of fluctuation may be due to variations of the energy input. However, any causal explanation must consider the internal continuous readjustment in the system as reported by the corresponding chaotic properties of the asymptotic decay of the spectra time structure. Since the output of noisy and chaotic systems tend to show similar spectral densities, an attempt to differentiate them has been carried out. The chaotic behaviour has been characterized by the study of the attractors. The dimmensions of these multiple topologies were 3.2 and 3.4 for the tree species and 2.3 for the fish species. Therefore, we are dealing with fractal attractors and the minimum number of variables that can be used to describe the systems are 4 and 3 respectively. It is suggested that some of the variables that most influence growth are those obtained by the response functions in the case of trees.
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    Bulletin of mathematical biology 51 (1989), S. 195-205 
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    Notes: Abstract In this article we present a method that allows conditioning of the response of a linear distributed memory to a variable context. This method requires a system of two neural networks. The first net constructs the Kronecker product between the vector input and the vector context, and the second net supports a linear associative memory. This system is easily adaptable for different goals. We analyse here its capacity for the conditional extraction of features from a complex perceptual input, its capacity to perform quasi-logical operations (for instance, of the kind of “exclusive-or”), and its capacity to structurate a memory for temporal sequences which access is conditioned by the context. Finally, we evaluate the potential importance of the capacity to establish arbitrary contexts, for the evolution of biological cognitive systems.
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    Bulletin of mathematical biology 51 (1989), S. 217-222 
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    Notes: Abstract Hoffmann (1982) analysed a very simple model of suppressive idiotypic immune networks and showed that idiotypic interactions are stabilizing. He concluded that immune networks provide a counterexample to the general analysis of large dynamic systems (Gardner and Ashby, 1970; May, 1972). The latter is often verbalized as: an increase in size and/or connectivity decreases the system stability. We here analyse this apparent contradiction by extending the Hoffmann model (with a decay term), and comparing it to an ecological model that was used as a paradigm in the general analysis. Our analysis confirms that the neighbourhood stability of such idiotypic networks increases with connectivity and/or size. However, the contradiction is one of interpretation, and is not due to exceptional properties of immune networks. The contradiction is caused by the awkward normalization used in the general analysis.
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    Bulletin of mathematical biology 51 (1989), S. 275-286 
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    Notes: Abstract In the commonly used model (Sokoloff) for the transport and metabolism of glucose and 2-deoxyglucose in brain tissue a novel choice of constant parameters is proposed. In particular, the maximal transport capacity for glucose is assumed proportional to the rate of glucose consumption. The proportionality factor, the “transport factor”, may be calculated from the lumped constant and is more likely than the latter to remain constant under varying conditions. Calculations founded on these considerations should yield results similar to the Sokoloff procedure in many situations, but differences appear when the arterial glucose concentration changes. The model is flexible and allows changes.
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    Bulletin of mathematical biology 51 (1989), S. 255-274 
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    Notes: Abstract We briefly review the results of other authors concerning the analysis of systems with time hierarchy, especially the Tikhonov theorem. A theorem, recently proved by the authors, making possible rigorous analysis of systems with complex fast dynamics is stated and discussed. A model example of a simple enzymatic reaction with product activation and slow (genetically driven) enzyme turnover is rigorously studied. It is shown that even in such a simple model there exist certain regions of parameters for which fast variables oscillate. Thus the classical Tikhonov theorem is not applicable here and we are forced to use another method-for example the author's presented theorem—or a purely numerical solution. These two methods are compared.
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    Bulletin of mathematical biology 51 (1989), S. 293-309 
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    Notes: Abstract The linear isobole that is commonly used as a reference for the study of interaction is derived from the interaction of an agent with itself. It is shown that the general use of the linear isobole in the study of the combined effects of mixtures of agents implies interaction between the agents whether the dose-effect curves of the agents are the same or not. It is difficult to generalize the interaction between two doses of the same agent to the interaction between two doses of different agents with different action mechanisms without the use of a mechanistic model. Predictions using non-interaction defined as independent action are generally different from those using linear isobole. A simple mechanistic framework based on the concept of common intermediate lesions is introduced in this paper to relate these two methods used for the analysis of synergism and antagonism. In this framework of lesion development, two agents that have no common intermediate lesion in their action will be non-interactive (referred to as independent action). When the two agents share a common intermediate, it is shown that the combined effect will follow the linear isobole (referred to as common action). This simple framework of analysis is applicable to the general study of interaction between two agents with different types of dose-effect curves.
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    Bulletin of mathematical biology 51 (1989), S. 117-124 
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    Notes: Abstract The comparison of entire genomes in evolutionary studies gives rise to alignments characterized by many intersections, or inversions in the order of two fragments in different genomes. To model this, we suggest a random migration process for fragments, and discuss its equilibrium distribution in the case of linear and circular genomes. Simulations are carried out to explore “cut-off” behavior as the process approaches equilibrium. We define a new process to take into account the indistinguishability of two fragments which are adjacent in both genomes being compared. Questions of applicability of these models are discussed.
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    Notes: Abstract There is still controversy as to which characteristics of the pressure-volume relation should be used to define myocardial contractility. In the present study a mathematical model for the left ventricle as a two-dimensional cylinder contracting radially and symmetrically was used to establish a relation between a calculated intramyocardial pressure (Dh) and theP-V relation (PVR) at end-systole. Four new indices are introduced that allow a better assessment of change in inotropic state of the myocardium, namely the calculated intramyocardial pressure (Dh), the calculated resultant pressure across the inner surface of the myocardium (Dh-P) (P=cavity pressure), the workW t related to the pressure (Dh) and the workW d related to the pressure (Dh-P). A relation betweenW t andW d and different parts of the area under the PVR is established. Indices derived in this manner from the PVR to study changes in myocardial contractility appear to have a clear physical meaning.
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    Bulletin of mathematical biology 51 (1989), S. 485-500 
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    Notes: Abstract A mathematical model for cell sorting and migration in the slug stage of cellular slime moldsDictyostelium discoideum is proposed. Assuming that a slug is a “mixed fluid” of prespore and prestalk cells, a set of equations which describe the dynamics of cell distribution, internal pressure and velocity of hte slug are derived from the balance formula of individual cell movement. These equations are analyzed to obtain the spatial patterns of the two types of cells at dynamical equilibrium and the relationship between the migration velocity and the slug size. The body shape of the elongated slug at the migrating stage is also investigated, taking account of the law of surface tension. The stable shapes of slugs with different volumes are explicity obtaained and the existence of critical size of a slug is suggested.
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    Bulletin of mathematical biology 51 (1989), S. 545-546 
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    Bulletin of mathematical biology 51 (1989), S. I 
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    Bulletin of mathematical biology 51 (1989), S. 547-547 
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    Bulletin of mathematical biology 51 (1989), S. 549-578 
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    Notes: Abstract The mesodermal tissue of some amphibian gastrula develops into a dorsal-to-ventral sequence of notochord, somite, pronephros, and lateral plate cell types. The cellular proportions regulate with respect to embryo size. The dorsal blastoporal lip appears to function as an organizer for the embryo. The transplantation of a donor lip to the ventral side of a host causes a second, opposed embryo to form and the system commits similar total proportions of cells as do normally developing embryos. Transplantation of donor somite to the ventral side of a host causes a reduction in the proportion of host somite developed. A modified reaction-diffusion system governing embryo development is proposed. Developmental simulations consistent with experimental observations are presented and analyzed. The results suggest that the degree of somite inhibition is positively correlated with the size of the somite transplant. Further predictions are that sufficiently large somite transplants would induce ectopic, ventral pronephros to form and ventral pronephros transplants would inhibit host pronephros development.
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    Bulletin of mathematical biology 51 (1989), S. 605-624 
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    Notes: Abstract Neurophysiological and anatomical observations are used to derive a non-linear delay-differential equation for the pupil light reflex with negative feedback. As the gain or the time delay in the reflex is increased, a supercritical Hopf bifurcation occurs from a stable fixed point to a stable limit cycle oscillation in pupil area. A Hopf bifurcation analysis is used to determine the conditions for instability and the period and amplitude of these oscillations. The more complex waveforms typical of the occurrence of higher order bifurcations were not seen in numerical simulations of the model. This model provides a general framework to study the different types of dynamical behaviors which can be produced by the pupil light reflex, e.g. edge-light pupil cycling.
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    Bulletin of mathematical biology 51 (1989), S. 579-596 
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    Notes: Abstract Amiodarone concentrationsy(t) have been measured from 1 min to more than 50 days following 10 min of infusion, with about 40 observations on each of six normal subjects (Tuckeret al., 1984,Eur. J. clin. Pharmacol. 26, 655–656). The form of the log-log plots—ln(y) vs ln(t)—is investigated. These appear to show three phases. First there is a rapid decrease ofy(t). then a straight line corresponding to a small negative power oft, ca −0.3, and this line changes continuously but quickly at about 0.5 day into a steeper line that is almost straight. For the curve fitting a simple “spline-type” device was successful. Two continuity conditions were imposed at the time of changeover, which was one of the unknown parameters. The results are compared in detail with those from a set of 15 radiocalcium curves obtained during 2 weeks or more from a single injection of47Ca (Neeret al., 1967,J. clin. Invest. 46, 1364–1379). Again two power functions of time can be seen. The changeover is much more gradual than with amiodarone, and the fits are still better. Both sets of curves are fitted with fewer adjustable parameters than with the usual multiexponentials that are interpreted in terms of homogeneous compartments. Theoretical and practical implications are mentioned. There is much indirect evidence that hundreds of other clearance curves may consist largely of one or two of such power functions of time.
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    Bulletin of mathematical biology 51 (1989), S. 625-638 
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    Notes: Abstract We propose the use of a stationary probability distribution for the analysis of data on population size. Predicting this long term population property from short term individual events is accomplished by the use of the asymptotic theory of stochastic processes. A WKB approximation to the stationary density is obtained and then applied to observations on the flour beetleTribolium.
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    Bulletin of mathematical biology 51 (1989), S. I 
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    Bulletin of mathematical biology 51 (1989), S. 639-655 
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    Bulletin of mathematical biology 51 (1989), S. 801-809 
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    Stochastic environmental research and risk assessment 3 (1989), S. 1-16 
    ISSN: 1436-3259
    Keywords: Width function ; instantaneous unit hydrograph ; peak ; regression ; birth-death process
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    Topics: Architecture, Civil Engineering, Surveying , Energy, Environment Protection, Nuclear Power Engineering , Geography , Geosciences
    Notes: Abstract We investigate optimal predictors of the peak (S) and distance to peak (T) of the width function of drainage networks under the assumption that the networks are topologically random with independent and exponentially distributed link lengths. Analytical results are derived using the fact that, under these assumptions, the width function is a homogeneous Markov birth-death process. In particular, exact expressions are derived for the asymptotic conditional expectations ofS andT given network magnitudeN and given mainstream lengthH. In addition, a simulation study is performed to examine various predictors ofS andT, includingN, H, and basin morphometric properties; non-asymptotic conditional expectations and variances are estimated. The best single predictor ofS isN, ofT isH, and of the scaled peak (S divided by the area under the width function) isH. Finally, expressions tested on a set of drainage basins from the state of Wyoming perform reasonably well in predictingS andT despite probable violations of the original assumptions.
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    Stochastic environmental research and risk assessment 3 (1989), S. 68-69 
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    Stochastic environmental research and risk assessment 3 (1989), S. 281-292 
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    Keywords: Generalised Pareto distribution ; Peaks over threshold ; Probability weighted moments ; Regionalisation
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    Notes: Abstract A peaks over threshold (POT) method of analysing daily rainfall values is developed using a Poisson process of occurrences and a generalised Pareto distribution (GPD) for the exceedances. The parameters of the GPD are estimated by the method of probability weighted moments (PWM) and a method of combining the individual estimates to define a regional curve is proposed.
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    Stochastic environmental research and risk assessment 3 (1989), S. 31-49 
    ISSN: 1436-3259
    Keywords: Reservoir operation ; prediction ; Kalman filtering ; flood prevention ; fuzzy control
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    Notes: Abstract Japan has traditionally performed flood prevention through the construction and use of dikes, storage reservoirs, and basins which are costly and time consuming options. Another non-structural option is to operate the flood control system appropriately with a view to reducing flood damage. In this paper, a flood control system combining the runoff prediction model in the whole river basin with the reservoir operation is discussed. Different models of the runoff process are introduced in order to compare their accuracies and the computational time for the flood forecasting system. The reservoir operational rule is formulated in terms of fuzzy inference theory. Historical data are applied in a case study for verification of the proposed theories.
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    Stochastic environmental research and risk assessment 3 (1989), S. 69-69 
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    Stochastic environmental research and risk assessment 3 (1989), S. 154-154 
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    Stochastic environmental research and risk assessment 3 (1989), S. 155-178 
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    Keywords: Stochastic differential equations ; Stochastic Taylor formula ; Numerical methods ; Simulations ; Strong convergence ; Weak convergence
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    Notes: Abstract The development of numerical methods for stochastic differential equations has intensified over the past decade. The earliest methods were usually heuristic adaptations of deterministic methods, but were found to have limited accuracy regardless of the order of the original scheme. A stochastic counterpart of the Taylor formula now provides a framework for the systematic investigation of numerical methods for stochastic differential equations. It suggests numerical schemes, which involve multiple stochastic integrals, of higher order of convergence. We shall survey the literature on these and on the earlier schemes in this paper. Our discussion will focus on diffusion processes, but we shall also indicate the extensions needed to handle processes with jump components. In particular, we shall classify the schemes according to strong or weak convergence criteria, depending on whether the approximation of the sample paths or of the probability distribution is of main interest.
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    Stochastic environmental research and risk assessment 3 (1989), S. 217-226 
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    Keywords: Stochastic integral equation method ; rainfall-runoff models ; confidence interval
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    Notes: Abstract The stochastic integral equation method (S.I.E.M.) is used to evaluate the relative performance of a set of both calibrated and uncalibrated rainfall-runoff models with respect to prediction errors. The S.I.E.M. is also used to estimate confidence (prediction) interval values of a runoff criterion variable, given a prescribed rainfall-runoff model, and a similarity measure used to condition the storms that are utilized for model calibration purposes. Because of the increasing attention given to the issue of uncertainty in rainfall-runoff modeling estimates, the S.I.E.M. provides a promising tool for the hydrologist to consider in both research and design.
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    Stochastic environmental research and risk assessment 3 (1989), S. 241-260 
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    Keywords: Hat matrix ; Mahalanobis distance ; Additive outliers ; Innovation outliers ; Influential data ; Autoregressive models ; Threshold autoregression ; Lake Huron
    Source: Springer Online Journal Archives 1860-2000
    Topics: Architecture, Civil Engineering, Surveying , Energy, Environment Protection, Nuclear Power Engineering , Geography , Geosciences
    Notes: Abstract A practical method is developed for outlier detection in autoregressive modelling. It has the interpretation of a Mahalanobis distance function and requires minimal additional computation once a model is fitted. It can be of use to detect both innovation outliers and additive outliers. Both simulated data and real data re used for illustration, including one data set from water resources.
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    Stochastic environmental research and risk assessment 3 (1989), S. 293-316 
    ISSN: 1436-3259
    Keywords: Confined aquifer ; Transmissivity identification ; Geostatistics ; Inverse problem ; Ill-posedness ; Ill-conditioning ; Stability analysis ; Regularization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Architecture, Civil Engineering, Surveying , Energy, Environment Protection, Nuclear Power Engineering , Geography , Geosciences
    Notes: Abstract In recent years, geostatistical concepts have been applied to the inverse problem of transmissivity estimation from piezometric head data. It has been claimed that such methods overcome various difficulties encountered in other approaches. However, the reconstruction of transmissivity from head measurements is ill-posed as it depends on derivatives of the head field. Consequently, any accurate method for its solution is likely to encounter numerically ill-conditioned systems. This paper reviews the geostatistical approach, and uses the stability analyses of linear algebra to show that, as the amount of available data increases and the discretization of the system is refined, both a numerically ill-conditioned parameter estimation problem and ill-conditioned cokriging equations may appear. Therefore, while the geostatistical approach does have conceptual appeal, it does not avoid the fundamental difficulties arising out of the ill-posed nature of transmissivity identification. Instead, the method is likely to be quite sensitive to these difficulties, so care must be taken in its formulation to minimize their effects. A means to stabilize the geostatistical method is suggested and numerical experiments that highlight key points of our analysis are given.
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    Mathematical programming 43 (1989), S. 31-44 
    ISSN: 1436-4646
    Keywords: Affine-scaling ; Karmarkar's algorithm ; dual algorithm ; feasibility algorithm
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science , Mathematics
    Notes: Abstract The affine-scaling modification of Karmarkar's algorithm is extended to solve problems with free variables. This extended primal algorithm is used to prove two important results. First the geometrically elegant feasibility algorithm proposed by Chandru and Kochar is the same algorithm as the one obtained by appending a single column of residuals to the constraint matrix. Second the dual algorithm as first described by Adler et al., is the same as the extended primal algorithm applied to the dual.
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    Mathematical programming 45 (1989), S. 35-47 
    ISSN: 1436-4646
    Keywords: Facets ; ternary ; covering ; packing
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    Topics: Computer Science , Mathematics
    Notes: Abstract We consider ternary matrices, i.e., integer matrices having all entries 0, 1 or 2. Three associated problems—the group problem, covering, and packing—are studied. General classes of vertices and facets are discussed in each case. Certain lifting procedures are also described. For all three problems techniques used are natural extensions of those used in the binary case.
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    Mathematical programming 45 (1989), S. 407-435 
    ISSN: 1436-4646
    Keywords: 49D05 ; 65K05 ; Conjugate gradient ; diagonal updates ; Hilbert spaces ; large-scale problems ; limited memory ; numerical experiments ; unconstrained optimization ; variable-metric algorithms ; variablestorage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science , Mathematics
    Notes: Abstract This paper describes some numerical experiments with variable-storage quasi-Newton methods for the optimization of some large-scale models (coming from fluid mechanics and molecular biology). In addition to assessing these kinds of methods in real-life situations, we compare an algorithm of A. Buckley with a proposal by J. Nocedal. The latter seems generally superior, provided that careful attention is given to some nontrivial implementation aspects, which concern the general question of properly initializing a quasi-Newton matrix. In this context, we find it appropriate to use a diagonal matrix, generated by an update of the identity matrix, so as to fit the Rayleigh ellipsoid of the local Hessian in the direction of the change in the gradient. Also, a variational derivation of some rank one and rank two updates in Hilbert spaces is given.
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    Mathematical programming 45 (1989), S. 529-546 
    ISSN: 1436-4646
    Keywords: Nonlinear optimization ; parallel computing ; block iterative methods ; truncated-Newton methods
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science , Mathematics
    Notes: Abstract Truncated-Newton methods are a class of optimization methods suitable for large scale problems. At each iteration, a search direction is obtained by approximately solving the Newton equations using an iterative method. In this way, matrix costs and second-derivative calculations are avoided, hence removing the major drawbacks of Newton's method. In this form, the algorithms are well-suited for vectorization. Further improvements in performance are sought by using block iterative methods for computing the search direction. In particular, conjugate-gradient-type methods are considered. Computational experience on a hypercube computer is reported, indicating that on some problems the improvements in performance can be better than that attributable to parallelism alone.
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    OR spectrum 11 (1989), S. 1-2 
    ISSN: 1436-6304
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    OR spectrum 11 (1989), S. 42-42 
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    OR spectrum 11 (1989), S. 3-16 
    ISSN: 1436-6304
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    Topics: Mathematics , Economics
    Description / Table of Contents: Zusammenfassung In diesem Beitrag wird ein Überblick über heuristische, prioritätsregelgestützte Auftragsreihenfolgeplanung gegeben. Prioritätsregeln sind in den letzten 30 Jahren eingehend anhand von Simulations-Experimenten untersucht worden. Sie haben ebenso in Programmsysteme zur Produktionsplanung und-steuerung Eingang gefunden. Der Beitrag bemüht sich um eine Klassifizierung, Charakterisierung und Beurteilung von elementaren Prioritätsregeln. Abschließend werden einige prioritätsregelrelevante Modellerweiterungen angeschnitten.
    Notes: Summary In this paper, we survey the literature on heuristic priority rule-based job shop scheduling. Priority rules have been intensively investigated over the last 30 years by means of simulation experiments. They are also used in Shop Floor Control software systems. We present a classification, a characterization, and an evaluation of elementary priority rules. Some priority rule-related model extensions are discussed.
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    OR spectrum 11 (1989), S. 17-24 
    ISSN: 1436-6304
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    Topics: Mathematics , Economics
    Description / Table of Contents: Zusammenfassung Betrachtet wird das Problem der Fahrplangestaltung im öffentlichen (Personen-)Nahverkehr mit dem Ziel der Minimierung der Summe der Wartezeiten für Umsteiger. Es werden heuristische Lösungsverfahren (Regret-Methoden, Verbesserungsverfahren, Simulated Annealing) sowie ein Branch-and- Bound-Algorithmus beschrieben. Die Verfahren wurden u. a. anhand von Daten aus der Praxis getestet.
    Notes: Summary The problem of minimizing waiting times of passengers who want to change communication routes at transfer stations is considered. The paper contains heuristics (regret-methods, improvement algorithms, simulated annealing) as well as a branch and boundalgorithm and provides computational results, some of them gained with practical data.
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    OR spectrum 11 (1989), S. 48-48 
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    OR spectrum 11 (1989), S. 25-41 
    ISSN: 1436-6304
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    Topics: Mathematics , Economics
    Description / Table of Contents: Summary A model is set up to simulate commercial flights in 4-D-mode. Basic data are standard flight tracks of German domestic flights; altitudes included range up to flightlevel FL 300. For simulation runs, flight times profiles are derived both from real flights and departure times respectively fly-over times of the Berlin gates. Aircraft movements are simulated with respect to airways, departure and arrival routes, air traffic control areas, starts and landings. Conflicts arise in the case of too short distances to other aircraft. They are solved dependently on flight attitude, e.g. en route state by changing the flight level, or by holding procedures if an aircraft cannot be sequenced for final approach. The simulation is carried out for 465 domestic flights per day. Some results and an outlook on suitable applications are given.
    Notes: Zusammenfassung Grundlagen des symbolischen Modells zur Simulation der Flugbewegungen in Zeit und Raum sind Standardrouten sowie Flughöhen bis FL 300. Flugzeiten und Flugprofile werden aus realen Flugeinsätzen abgeleitet. Die Nachbildung erfolgt in Luftstraßen, An- und Abflugrouten, CTA- und FIR-Gebieten sowie für Starts und Landungen. Vor jedem LFZ wird in Flugrichtung ein Sicherheitsbereich eingerichtet, dessen Unterschreitung durch andere LFZ Konflikte verursacht. Konfliktlösungen erfolgen unterschiedlich nach Flugzuständen, z. B. durch Flugflächenwechsel (Reiseflug) oder Warterunden (Platzanflug), falls ein LFZ zum Endanflug nicht in eine Landekette eingereiht werden kann. Die Simulation erfolgt für 465 Flüge eines Tages im nationalen Verkehr. Es werden einige Ergebnisse angegeben, ferner ein Ausblick auf mögliche Anwendungen des Modells.
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    OR spectrum 11 (1989), S. 43-47 
    ISSN: 1436-6304
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics , Economics
    Description / Table of Contents: Zusammenfassung Die Klasse von sogenannten lexicographisch monotonen Verhandlungslösungen für Verhandlungsprobleme mit zwei Spielem wird in mehreren Weisen charakterisiert. Diese Lösungen sind nichtsymmetrische Verallgemeinerungen der lexicographisch egalitaren Lösung. In dieser Charakterisierung wird Monotonie der Lösung erfordert nur wenn der Lösungspunkt nicht ein Endpunkt der Pareto optimalen Menge ist. Diese Kondition wird interpretiert als Natürlichkeit oder Zwangslosigkeit der Übereinstimmung zwischen den Spielern.
    Notes: Summary The family of 2-person bargaining solutions called Lexicographic monotone path solutions — which are nonsymmetric generalizations of the lexicographic egalitarian solution — is characterized in several ways. Central in these characterizations is an interiority condition first introduced in [1] in order to characterize then-person lexicographic egalitarian solution. This condition means that a monotonicity property is required to hold only if the agreement is an interior Pareto optimal point, the interpretation being that in that case the agreement is “natural” or “unforced”.
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    OR spectrum 11 (1989), S. 63-63 
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    OR spectrum 11 (1989), S. 64-64 
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    Description / Table of Contents: Summary The purpose of this article is twofold. In the first place it serves as an introduction the using of the simultaneous equations method as compare with step method of cost allocation in computer centre. The model is based on the principle that no expense any service department should be distributed unless all of its expenses, including services received from other service departments, are included. Using the simultaneous equations method, ratios for distributing expenses of service departments to production departments are established which take into consideration the interaction between and among the various service departments. In the second place, to illustrate the formulating a description of a problem in terms of mathematical equations and interpreting the results.
    Notes: Zusammenfassung Der Artikel verfolgt zwei Ziele. Zum einen wird der Gebrauch simultaner Gleichungsrechnungen in der innerbetrieblichen Leistungsverrechnung im Vergleich zur sukzessiven Kostenauflösung nach der Zuschlagmethode demonstriert. Es werden Leistungsaustauschvorgänge zwischen produzierenden und/oder verwaltenden Stellen aufgezeigt. Zum anderen wird die Lösung und die Interpretation der Ergebnisse gezeigt.
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    OR spectrum 11 (1989), S. 64-64 
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    OR spectrum 11 (1989), S. 65-66 
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    OR spectrum 11 (1989), S. 96-96 
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    OR spectrum 11 (1989), S. 83-88 
    ISSN: 1436-6304
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics , Economics
    Description / Table of Contents: Zusammenfassung Eine Verallgemeinerung von Fluß-spielen, nämlich solchen mit Komitee-Kontrolle, wird in der vorliegenden Arbeit betrachtet, um eine Darstellung nicht-negativer ausgewogener Spiele zu erhalten. Die Komitee-Kontrolle wird mit Hilfe einfacher Spiele modelliert. Ebenso werden lineare Produktionsspiele mit Komitee-Kontrolle untersucht, und Ergebnisse zur Ausgewogenheit solcher Spiele werden hergeleitet.
    Notes: Summary A generalization of flow games, namely, flow games with committee control is considered, to obtain a representation of non-negative balanced games. The committee control is modeled with the aid of simple games. Linear production games with committee control are also studied and results on the balancedness of such games are obtained.
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    OR spectrum 11 (1989), S. 89-95 
    ISSN: 1436-6304
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    Topics: Mathematics , Economics
    Description / Table of Contents: Zusammenfassung Ein Fahrzeuggetriebe läßt sich als System modellieren, dessen Zustände (= Gänge) einen Markov-Prozeß darstellen. Jeder Gang benützt eine charakteristische Untermenge von Komponenten (= Zahnräder usw.). Die Ausfallrate jeder Komponente wächst linear mit der zurückgelegten Betriebszeit. Der erste Ausfall einer im Einsatz befindlichen Komponente führt zum Ausfall des Getriebes. Für die Überlebensfunktion werden Konvergenzresultate und Schranken angegeben. Mittelwert und Varianz der Systemlebensdauer streben mit fallenden Ausfallraten gegen die entsprechenden Werte einer Rayleighverteilung. Die bedingten Wahrscheinlichkeiten einer Komponente, einen Defekt nach Überleben der Zeitspanne τ zu verursachen, streben asymptotisch mit τ gegen die mittleren, stationären relativen Schadensakkumulationsraten. Ein Schätzverfahren für die Modellparameter bei gegebener stationärer Verteilung des Markov-Prozesses schließt die Untersuchung ab.
    Notes: Summary A vehicle transmission box is modeled as a system, whose operating states (= speeds) perform a Markov-process. Every speed uses its own subset of components (= gears etc.). The failure rate of a component increases linearly with its accumulated operating time. The first failure of a gear causes system failure. Asymptotic results and bounds are given for the system survival function. Mean value and variance of the system lifetime tend towards their counterparts in case of a Rayleigh distribution, as component failure rates converge towards 0. The conditional posterior culprit probabilities, i.e. the probabilities to cause a system failure, given survival of a time span τ, converge asymptotically towards the stationary expected relative damage accumulation rates as τ increases. Estimators for the model parameters are given for a known stationary distribution of the Markov-process.
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    OR spectrum 11 (1989), S. 101-110 
    ISSN: 1436-6304
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    Topics: Mathematics , Economics
    Description / Table of Contents: Zusammenfassung In dieser Arbeit wird ein mathematisches Modell zur Optimierung der Entladestrategie für Schiffe vorgestellt, die Schuttgüter transportieren. Unter Verwendung der Ergebnisse einer vorherigen Arbeit, die sich mit Entladeoperationen einer einzelnen Luke befaßte, wird hier die Minimierung der gesamten Entladezeit angestrebt, wobei Ablaufplanungsalgorithmen benutzt werden, die auf einer simplen Prioritätsregel basieren. Zur Validierung dieses heuristischen Ansatzes wird ebenfalls ein gemischt-ganzzahliges Optimierungsmodell eingeführt, welches Untergrenzen für die Entladezeit liefert durch Lockerung einzelner Ganzzahligkeitsrestriktionen.
    Notes: Summary A mathematical model for the optimization of the unloading strategy for ships transporting bulk goods will be presented in this paper. Using the results of a previous paper concerning the unloading operation of a single hatch, the minimization of the overall unloading time is striven for by using scheduling algorithms based on a simple priority rule. For validation of this heuristic approach a mixed-integer optimization model will also be introduced, which delivers lower bounds for the unloading time by relaxing some of the integrality constraints.
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    OR spectrum 11 (1989), S. 113-113 
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    OR spectrum 11 (1989), S. 111-113 
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    OR spectrum 11 (1989), S. 142-142 
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    OR spectrum 11 (1989), S. 121-130 
    ISSN: 1436-6304
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    Description / Table of Contents: Summary A system withn elements in sequence is called a consecutive-k-out-of-n:F system if it fails wheneverk consecutive elements are failed. Consecutive-k-out-of-n:F systems can be used to model belt conveyor systems, telecommunication systems, oil pipeline systems, street lightings and other more. This paper presents formulas and algorithms for the reliability of consecutive-k-out-of-n:F systems with identical and nonidentical elements.
    Notes: Zusammenfassung Ein konsekutives-k- aus-n:F System besteht aus einer Folge vonn Elementen. Das System ist genau dann ausgefallen, wennk aufeinanderfolgende Elemente ausgefallen sind. Konsekutive-k-aus-n:F Systeme können zur Modellierung von Gurtbandförderern, Telekommunikationssystemen, Ölpipelinesystemen, Straßenbeleuchtungsanlagen usw. herangezogen werden. Diese Arbeit faßt Formeln und Algorithmen für die Zuverlässigkeit von konsekutiven-k-aus-n:F Systemen mit identischen und nichtidentischen Elementen zusammen.
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    OR spectrum 11 (1989), S. 131-141 
    ISSN: 1436-6304
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    Topics: Mathematics , Economics
    Description / Table of Contents: Zusammenfassung Tabu Search ist eine heuristische Methode, die für globale Optimierung mit viel Erfolg in verschiedenen Umständen angewandt wurde. Die Grundideen der Methode werden erklärt und mit Beispielen illustriert. Eine Anwendung an ein Lernprozess im Gebiet der Neuronen Netzwerke wird beschrieben.
    Notes: Summary Tabu Search is a general heuristic procedure for global optimization. Based on simple ideas it has been extremely efficient in getting almost optimal solutions for many types of difficult combinatorial optimization problems. The principles of Tabu Search are discribed and illustrations are given. An example of problem type where the use of Tabu Search has drastically cut down the computational effort is presented; it consists of the learning process of an associative memory represented by a neural network.
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    OR spectrum 11 (1989), S. 143-149 
    ISSN: 1436-6304
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    Description / Table of Contents: Zusammenfassung Hastings [1] benutzt Reparaturgrenzen für Ersetzungsprobleme: wenn zu einem Zeitpunkt die Reparatur eines Fahrzeugs (z. B.) hinreichend teuer ist, dann ist es ökonomisch sinnvoll, das Fahrzeug durch ein neues zu ersetzen. Numerische Resultate zeigten, daß diese Reparaturgrenzen monoton fallend sind mit zunehmendem Alter. Außerdem wurde angenommen, daß die Fahrzeuge in einem gewissen Alter unabhängig von den Raparaturkosten ersetzt werden. Die vorliegende Arbeit befaßt sich mit der theoretischen Untersuchung dieser beiden Fragen.
    Notes: Summary Hastings [1] introduced the concept of repair limits for replacement problems, the basic idea being that if, at a given time, the repair of a vehicle, for example, is sufficiently expensive, then it will be economical to replace the vehicle with a new one. Numerical results also demonstrated that repair limits decreased with age. In addition, it was assumed that, at a certain age, vehicles should be replaced whatever the repair cost. This paper addresses theoretical issues surrounding these questions.
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    OR spectrum 11 (1989), S. 150-150 
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    OR spectrum 11 (1989), S. 169-171 
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    OR spectrum 11 (1989), S. 159-167 
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    Description / Table of Contents: Summary The COMO III program has been used by IABG since 1975 for a great number of OR studies on air defence problems. The program has proved to be very well qualified for this purpose. In particular, the user-friendly and flexible data input for simulation runs should be stressed as well as the modular structure of the program which allows an optionally refined or aggregated modelling of the systems to be studied. Besides this, COMO III provides a standardised user-oriented data output which is sufficient for most study purposes and needs no additional programming effort.
    Notes: Zusammenfassung Das Programm COMO III, das seit 1975 bei der IABG in zahlreichen OR-Untersuchungen auf den Gebieten der Luftverteidigung und Flugabwehr verwendet wird, hat sich für derartige Untersuchungen als sehr gut geeignet erwiesen. Hervorzuheben sind insbesondere die benutzerfreundliche und flexible Dateneingabe für die Simulationsläufe sowie der modulare Aufbau des Modells, der es ermöglicht, die Abbildung der zu untersuchenden Systeme beliebig zu verfeinern oder zu aggregieren. COMO III sieht außerdem standardmäßig eine benutzerorientierte Datenausgabe vor, die für die meisten Untersuchungszwecke ausreicht und keinen zusätzlichen Programmaufwand erfordert.
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