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  • Articles  (57,788)
  • Elsevier  (56,029)
  • Nature Publishing Company  (1,759)
  • 1985-1989  (56,045)
  • 1950-1954  (1,743)
  • Biology  (57,788)
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  • Articles  (57,788)
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  • 1
    Electronic Resource
    Electronic Resource
    Enkephalins Prouduced in Transgenic Plants Using Modified 2S Seed Storage Proteins (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 929-932 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] We have explored the possibility of producing large amounts of biologically active peptides as part of chimeric plant seed storage proteins, the 2S albumins. A portion of an Arabidopsis thaliana 2S albumin gene, encoding a region of the protein whose sequence is not highly conserved among different ...
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    URL: http://dx.doi.org/10.1038/nbt0989-929
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  • 2
    Electronic Resource
    Electronic Resource
    New Products (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 960-964 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Retinoblastoma Antibody PharMingen (San Diego, CA) will make available monoclonal antibodies specific for the human retinoblastoma (RB) gene product, a protein thought to be important in cancer suppression and cell growth regulation. These antibodies immunoprecipitate authentic RB proteins, are ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt0989-960
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  • 3
    Electronic Resource
    Electronic Resource
    Announcements (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 966-966 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] SEPTEMBER MEETINGS Sept. 13–15. PaineWebber-Bio/Technolo-gy Conference: Biopharmaceuticals 1989. San Diego, CA. Info: Diana Berger, Nature Publishing Co., 65 Bleecker Street, New York, NY 10012, Tel: 212-477-9600. Sept. 17–19. The 2nd International Ion Chromatography Forum. Boston, ...
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    URL: http://dx.doi.org/10.1038/nbt0989-966
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  • 4
    Electronic Resource
    Electronic Resource
    Missing Microbial (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 967-967 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] To the editor: It was delight turned chagrin when I picked up the May '89 issue of Bio/Technology and found your article “Microbial Product Discovery in the Biotech Age” (Bio/Technology 7:427, May '89). My delight quickly faded as I failed to find reference to Panlabs Inc., which is ...
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    URL: http://dx.doi.org/10.1038/nbt0989-967c
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  • 5
    Electronic Resource
    Electronic Resource
    Will Research Success Increase Risk of Bias? (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 753-753 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] WASHINGTON, D.C.—Because of their growing potential for commercial payoffs, federally sponsored bio-medical research programs are coming under sharp scrutiny. Borderlines between basic and applied commercial research have blurred, raising concerns that increased numbers of researchers are ...
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    URL: http://dx.doi.org/10.1038/nbt0889-753
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  • 6
    Electronic Resource
    Electronic Resource
    Protein Patent Problem to Hinder Research? (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 764-764 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] BERNE, Switzerland—Will the commercial development and patenting of useful pharmacologically active proteins cease, once substantial parts of the human genome have been sequenced? The question was raised by Norman Carey, director of scientific affairs at Celltech (Slough, U.K.), during a ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt0889-764b
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  • 7
    Electronic Resource
    Electronic Resource
    Japan Roundup (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 766-766 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Scientists at the Industrial Research Council's Research Institute for Techniques in Industrial Microbiology (Tokyo) have discovered a new biopolymer that can absorb 500 times its own weight in salt water. Its ability to absorb fresh water is even greater—one gram can absorb one liter. Unlike ...
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    URL: http://dx.doi.org/10.1038/nbt0889-766
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  • 8
    Electronic Resource
    Electronic Resource
    Functional Expression of Human Monoclonal Antibody Genes Directed Against Pseudomonal Exotoxin A in Mouse Myeloma Cells (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 805-810 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] We have cloned immunoglobulin (Ig) genes from an Epstein-Barr (EB) virus-transformed human B cell line, FK-001, which produced a monoclonal human IgM that specifically binds Pseudomonas aeruginosa exotoxin A (Ex-A). Cloned Ig genomic DNA was introduced into Ig non-producing mouse myeloma cells, ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt0889-805
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  • 9
    Electronic Resource
    Electronic Resource
    Composite Filters for the Lab (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 825-825 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Filtration is a universal step for cleaning up samples before chromatography or other analytical procedures. An effective filtration process improves the accuracy of subsequent steps and extends the lifetime of more expensive separation media. But filtration is difficult with protein-rich fluids, ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt0889-825
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  • 10
    Electronic Resource
    Electronic Resource
    Renaturation and Purification of Biologically Active Recombinant Human Macrophage Colony-Stimulating Factor Expressed in E. Coli (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 710-715 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Recombinant human macrophage colony-stimulating factor (M-CSF), a disulfide-linked dimeric protein containing 18 cysteines, has been purified in monomeric form from E. coli and renatured to generate fully active dimers with an overall yield of 25 percent. M-CSF monomers were quantitatively refolded ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt0789-710
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  • 11
    Electronic Resource
    Electronic Resource
    Free Literature (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 727-727 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] VWR Scientific (San Francisco, CA) introduces the VWR Safety Showcase catalog, featuring descriptions and photos of personal protection and employee safety products for science and industry. Write in 701 on Reader Service Card A color brochure from JM Science (Buffalo, NY) describes recycling ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt0789-727
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  • 12
    Electronic Resource
    Electronic Resource
    New Products (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 723-726 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] HK™ phosphatase from Epicentre Technologies (Madison, WI) replaces calf intestinal and E. coli bacterial alkaline phosphatases for cloning and DNA labeling. There is no need for phenol and chloroform extractions or ethanol precipitations, which cause DNA loss. Free of exonuclease activity, ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt0789-723
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  • 13
    Electronic Resource
    Electronic Resource
    Potential AIDS Treatments, Some New Names (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 537-540 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Trials of experimential AIDS drugs set. Scientists from the University of California-San Francisco and Gene-labs (Redwood City, CA) will begin Phase I human trials next month to test the effectiveness of the compound GLQ223 as a treatment for acquired immunodeficiency syndrome (AIDS). This follows ...
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    URL: http://dx.doi.org/10.1038/nbt0689-537
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  • 14
    Electronic Resource
    Electronic Resource
    Corn: From Protoplasts to Fertile Plants (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 548-548 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Plant biotechnologists have taken another important step towards the genetic engineering of maize. Two papers in this issue of Bio/Technology report the regeneration of fertile corn plants from protoplasts. Although our group had previously demonstrated the regeneration of mature plants from the ...
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    URL: http://dx.doi.org/10.1038/nbt0689-548
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  • 15
    Electronic Resource
    Electronic Resource
    Of EPA, Risks, and Rule Making (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 555-555 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] WASHINGTON, D.C.—The specter of biotechnology gone amok continues to haunt the Environmental Protection Agency (EPA). Charged under the Toxic Substances Control Act (TSCA) with regulating the commercial use of microorganisms, the agency does not want to risk public disapproval by appearing to ...
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    URL: http://dx.doi.org/10.1038/nbt0689-555
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  • 16
    Electronic Resource
    Electronic Resource
    Free Literature (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 831-831 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Biological Materials. Biological Specialty (Lansdale, PA) offers a brochure listing products such as anticoagulants, source plasma (human), disease-state plasma, and normal mother's milk. The products, shipped in either dry ice, wet ice, or at ambient temperature, are guaranteed for delivery within ...
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    URL: http://dx.doi.org/10.1038/nbt0889-831
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  • 17
    Electronic Resource
    Electronic Resource
    Military Applications of Biotech (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 447-451 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The first priority of the military in the United States is to improve its defense technology. Advances in biotechnology can help better the accuracy of defense systems, protect national security, and assess military threats. Its applications can aid in detecting mines, explosives, and chemical and ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt0589-447
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  • 18
    Electronic Resource
    Electronic Resource
    Filtering Out Inhibition (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 462-463 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Since the birth of hollow fiber bioreactor technology in the 1970s1, this method for growing cells in a three-dimensional environment similar to solid tissues has proved useful for recovering products secreted by cells2. By using ultrafiltration membrane-based hollow fiber cartridges with low ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt0589-462
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  • 19
    Electronic Resource
    Electronic Resource
    Regulators Eye Hematopoietic Factors (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 653-653 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] WASHINGTON, D.C.—U.S. Food and Drug Administration (FDA, Rockville, MD) officials say they are “still ruminating” on how to regulate hematopoietic factors. But even if policies have not yet solidified, agency officials are fortifying themselves intellectually for the coming feast ...
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    URL: http://dx.doi.org/10.1038/nbt0789-653
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  • 20
    Electronic Resource
    Electronic Resource
    Observations on the Development of Biotechnology Centers: The Birth of the CBC (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 684-685 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The first centers devoted to local, regional, or statewide development of biotechnology were started in North Carolina and Michigan only eight years ago. Subsequently more than 50 of these centers in more than 30 states have emerged as clear catalysts in the advancement of biotechnology in the ...
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    URL: http://dx.doi.org/10.1038/nbt0789-684
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  • 21
    Electronic Resource
    Electronic Resource
    High-Level Expression and In Vivo Processing of Chimeric Ubiquitin Fusion Proteins in Saccharomyces Cerevisiae (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 705-709 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] We have developed a system for the regulatable production of high levels of correctly processed heterologous proteins in the yeast Saccharomyces cerevisiae. An expression vector, pBS24Ub, that contains a synthetic gene for yeast ubiquitin (Ub) was constructed. The gene was expressed under the ...
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    URL: http://dx.doi.org/10.1038/nbt0789-705
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  • 22
    Electronic Resource
    Electronic Resource
    New Clues on Folding (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 324-325 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] SAN FRANCISCO—Some experimental model systems are as comfortable and familiar to scientists as old friends. Generations of geneticists and molecular biologists have been raised on bacterial enzymes—such as tryptophan synthase—and bacterial viruses—such as phage f1. What more ...
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    URL: http://dx.doi.org/10.1038/nbt0489-324
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  • 23
    Electronic Resource
    Electronic Resource
    Measuring Contaminating DNA in Bioreactor Derived Monoclonals (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 343-347 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Pharmaceutical manufacturers need to accurately quantity picogram amounts of contaminating DNA in recombinant proteins and monoclonal antibodies intended for therapeutic use. Generally, this requires an assay capable of detecting 10 picograms or less of contaminating DNA per dose of product. ...
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    URL: http://dx.doi.org/10.1038/nbt0489-343
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  • 24
    Electronic Resource
    Electronic Resource
    Immobilization Methods for Piezoelectric Biosensors (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 349-351 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Conceptually, biosensors are relatively simple measuring devices that incorporate a biologically active sensing material into a transducer. In practice, researchers continue to search for ideal combinations of biocatalysts—enzymes, antibodies, antigens, bacteria, whole cells, plant slices, ...
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    URL: http://dx.doi.org/10.1038/nbt0489-349
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  • 25
    Electronic Resource
    Electronic Resource
    High Expression in Mammalian Cells Without Amplification (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 359-362 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] We have used mammalian cell lines, constructed with the expression system described, to express high levels of a heterologous gene product (human growth hormone) without recourse to gene amplification. The system employs commonly available components that combine efficiently to yield high ...
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    URL: http://dx.doi.org/10.1038/nbt0489-359
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  • 26
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    Electronic Resource
    Is New NIH Review Needed? (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 329-331 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] WASHINGTON, D.C.—U.S. District Court Judge George Revercomb is now reviewing the merits of a lawsuit brought against the National Institutes of Health (NIH, Bethesda, MD) by Jeremy Rifkin and the Foundation on Economic Trends (Washington, DC). The suit contends that NIH is not meeting the ...
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    URL: http://dx.doi.org/10.1038/nbt0489-329b
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  • 27
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    Electronic Resource
    Crop Biotech '89: Research Efforts are Market Driven (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 337-341 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Investing in an unproven research area entails a considerable economic risk. Outside capital is limited, and corporations today are definitely risk averse, forcing biotech companies to devote their resources to fewer and more targeted projects—usually those with well-defined prospects for ...
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    URL: http://dx.doi.org/10.1038/nbt0489-337
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  • 28
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    Bacterial Expression, Facile Purification and Properties of Recombinant Human Lymphotoxin (Tumor Necrosis Factor Beta) (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 363-368 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] We have expressed a synthetic recombinant human TNF–β(rhTNF–β) gene in Escherichia coli to give rhTNF–β in a soluble, highly active and intact form. The specific activity of rhTNF–β purified in a single, convenient step from bacterial lysates was ...
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    URL: http://dx.doi.org/10.1038/nbt0489-363
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  • 29
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    Third World Science Groups Form Network (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 213-213 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] NEW YORK—Spurred in part by the United Nations' mixed record of success in stimulating Third World scientific endeavors—especially R&D and information exchange—concerned scientists have launched their own initiative. Last October, they inaugurated the Third World Network of ...
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    URL: http://dx.doi.org/10.1038/nbt0389-213
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  • 30
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    A Ray of Hope for Animal Patents in Europe (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 221-221 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] ITHACA, N.Y.—One topic generating much discussion at the Cornell University Animal Patent Symposium, held here in December, was inventors' frustrations at their inability to patent higher plants and animals in Europe. Although most of the symposium dealt with U.S. patent issues and their ...
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    URL: http://dx.doi.org/10.1038/nbt0389-221
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  • 31
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    Need for Money Spurs Lobby (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 422-422 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] NEW YORK—The Food and Drug Administration (FDA) is facing a dilemma. More and more products of biotechnology are making their way through the regulatory approval process, straining the agency's existing resources. At the same time, the federal government has been looking for ways to narrow ...
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    URL: http://dx.doi.org/10.1038/nbt0589-422
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  • 32
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    Biotech: Experimental Subject (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 216-216 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] NEW YORK—Two Cornell University (Ithaca, NY) professors are attempting to determine the most effective ways to finance and manage the transfer of basic biotechnology research to the marketplace. In a study expected to take three to five years, John Freeman of the Johnson School of Management ...
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  • 33
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    A Congressional Mandate for Military Research (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 448-448 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] In March 1989, in response to a congressional mandate, the Departments of Defense and Energy designated 22 technologies as critical to national security and the long-term superiority of weapons systems. The parameters for selection included: an ability to significantly enhance particular weapons ...
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  • 34
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    Efficient Degradation of Trichloroethylene by a Recombinant Escherichia Coli (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 282-285 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] We have identified a strain of Pseudomonas mendocina that oxidizes trichloroethylene (TCE) after growth in the presence of toluene. A DNA fragment from this organism, when introduced into the appropriate expression vector system, conferred upon Escherichia coli the ability to oxidize both toluene ...
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    Patents and Secondary Considerations (1989)
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    Nature biotechnology 7 (1989), S. 312-312 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] A basic fact of free enterprise is this: unless someone has a chance to make a profit by developing a new product, then no one will make the investments necessary to bring that product to the marketplace. A second basic fact is equally obvious: unless a product is manufactured and sold, it cannot ...
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    More Than Meats the Eye (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 103-103 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Back when life was, if not simpler, complex in different ways, we read not Nature and Yachting but Scientific American and Boys' Life, and took as our guide in all things temporal and spiritual a burro named Pedro. It is hard to confess these things, harder still to admit to the bits of boyhood ...
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    Japan Roundup (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 124-124 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] Using recombinant DNA (rDNA) techniques, Japanese scientists have inserted the erbB-2 oncogene into a vaccinia virus. Mice injected with the recombinant virus produced anti-erbB-2-antibodies which protected them against a later injection of breast cancer cells. Masashi Yamamoto's group at Tokyo ...
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    USDA Panel Evaluates Cattle Vaccine Test (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 123-123 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] WASHINGTON, D.C.—The Agricultural Biotechnology Research Advisory Committee (ABRAC), still negotiating its proper mandate, also for the first time tackled a far more concrete issue during its meeting early in January at U.S. Department of Agriculture (USDA) headquarters. The committee ...
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    Continuous Production of a Novel Lysozyme via Secretion from the Yeast, Pichia pastoris (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 160-164 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] We have cloned a cDNA for bovine lysozyme c2, a novel lysozyme characteristic of the cow stomach and expressed its protein product by secretion using its native signal sequence in the methylotrophic yeast, Pichia pastoris. A semi–continuous fermentation process used for production resulted in ...
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    Catching the Fever, Faster (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 1211-1211 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] On Wednesday morning, with the news that Jordi Casals was going downhill more rapidly than ever, a major meeting was called in Room 608 of the library of the Yale arbovirus laboratory. Just before the meeting, Wil Downs put through a phone call to his colleague, Dr. Karl Johnson, a leading ...
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    Biotech Changing Agribusiness (1989)
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    Nature biotechnology 7 (1989), S. 219-219 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] SAN FRANCISCO—Biotechnology stands poised to catalyze a major change in the structure of worldwide agribusiness. According to John M. Hardinger, director of biotechnology at E. I. du Pont de Nemours' (Wilmington, DE) agricultural products department, the increasing application of molecular ...
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    Chromatography: 1989 Report (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 243-249 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Just three or four years ago, when biotech stocks were riding high and interferon was going to cure everything from cancer to the common cold, holding down biopharmaceutical production costs was not exactly high priority. “People said, ‘Oh, don't bother messing with processing. These ...
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    Use of Bacteriocin Release Protein in E. Coli for Excretion of Human Growth Hormone into the Culture Medium (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 267-271 
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    Notes: [Auszug] Because of the outer membrane barrier, the gram–negative bacterium E. coli is generally not considered to be an appropriate host for the excretion of proteins into the culture medium. However, we have been able to efficiently excrete a mammalian protein, human growth hormone (hGH), into the ...
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    Free Literature (1989)
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    Nature biotechnology 7 (1989), S. 301-301 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] Titration in Progress, a 16-page color pamphlet from Radiometer Analytical A/S (Bagsvaerd, Denmark), provides a survey of systems, including titration for water analysis, COD determinations, and pH control. The brochure, outlining selection criteria, is available in both English and German. Write ...
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    Company Pacts Signal Commercial Progress (1989)
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    Nature biotechnology 7 (1989), S. 107-108 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The Hambrecht & Quist (H & Q, San Francisco, CA) Seventh Annual Healthcare Conference provided the forum for a slew of corporate announcements. Among them, Cetus (Emeryville, CA) and Hoffmann-La Roche (Roche, Nutley, NJ) will collaborate on the development and commercialization of human ...
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    Implantable Glucose Sensor Expected Soon (1989)
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    Nature biotechnology 7 (1989), S. 116-116 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] GöHREN, G.D.R.—For patients afflicted with insulin-dependent diabetes mellitus (IDDM), controlling blood glucose at near-normal levels can best reduce the disease's long-term, life-threatening cardiovascular side effects. An implantable glucose sensor would greatly aid in controlling ...
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    Human Disease Genes Elude Identification (1989)
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    Nature biotechnology 7 (1989), S. 120-120 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] TORONTO, Ont.—“On Chorea,” the only scientific treatise by Long Island, NY physician George Huntington, is over a century old. Yet, despite decades of concentrated effort by scores of research scientists, the gene that causes Huntington's disease remains unidentified. So, too, for ...
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    Somatic Embryogenesis and Plant Regeneration in Suspension Cultures of Dessert (AA and AAA) and Cooking (ABB) Bananas ( Musa spp.) (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 154-159 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] Proembryogenic calli were initiated from basal leaf sheaths and rhizome tissue on modified Schenk and Hildebrandt (SH) medium with 30 μM 3,6–dichloro–2–meth–oxybenzoic acid (Dicamba). Cell suspensions were maintained in half–strength Murashige and Skoog (MS) medium ...
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    Different Approaches to Stabilize a Recombinant Fusion Protein (1989)
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    Nature biotechnology 7 (1989), S. 165-168 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] We have used a fusion protein between staphylococcal protein A and E. coli β–galactosidase as a model system to investigate different approaches to stabilize recombinant gene products. First, growth conditions were adapted to preferentially produce insoluble inclusion bodies. This ...
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    New Products (1989)
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    Nature biotechnology 7 (1989), S. 179-182 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] Many of this month's new products will be on display at the Miami Bio/Technology Winter Symposium, February 6–10. For a closer look, visit the manufacturers at their booths. Preparative HPLC packings. Bakerbond™ wide-pore bulk packings (15-micron diameter) from J. T. Baker ...
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    Free Literature (1989)
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    Nature biotechnology 7 (1989), S. 183-183 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] Shimadzu Scientific Instruments (Columbia, MD) offers a full-color, four-page brochure providing an overview of the IBM PC-interface software for UV-visible spectroscopy. Photographs of 14 computer screens show how the software works with the company's UV-160, -265, and -3000 spectrophotometers. ...
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    Germany Quashes Plant, New Japan Inroads (1989)
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    Nature biotechnology 7 (1989), S. 1213-1216 
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    Notes: [Auszug] Insulin setbacks. A West German court ordered Hoechst (Frankfurt, F.R.G.) to stop construction of a test plant for producing genetically engineered human insulin. The court based its ruling, announced early in November, on the absence of specific parliamentary authorization allowing the use of gene ...
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    Environmental Research Gets a Boost (1989)
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    Nature biotechnology 7 (1989), S. 1223-1223 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] LONDON—Research into the fate of pollutants in the environment and their effects on ecosystems, and developing biotechnologies to remove toxic chemicals from effluents and waterways, are among the principal objectives of the new European Environmental Research Organization (EERO). Established ...
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    New FDA Biotech Office (1989)
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    Nature biotechnology 7 (1989), S. 1228-1228 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] WASHINGTON, D.C.—The U.S. Food and Drug Administration (FDA, Bethesda, MD) recently established a new Office of Biotechnology within the Office of the Commissioner, to be headed by Henry Miller, formerly a special assistant to FDA Commissioner Frank Young. Miller, who has been an aggressive ...
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    Enzymes in the Fine Chemicals Industry: Dreams and Realities (1989)
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    Nature biotechnology 7 (1989), S. 1238-1241 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] Although there's been considerable interest in using biocatalysts to produce fine organic chemicals, they are still made mainly by classic synthetic routes. Even after 20 years, biocatalysts haven't come into their own as major production tools in this area: nor will they—the markets just ...
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    Denmark OKs Trial of Engineered Beets (1989)
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    Nature biotechnology 7 (1989), S. 1001-1001 
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    Notes: [Auszug] LONDON—The year 1990 promises to be a milestone for biotechnology on the European continent, with the first officially sanctioned releases of engineered organisms into the environment in Denmark and West Germany—the two countries with the most sensitive climate of opinion surrounding ...
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    Enhanced Expression of an Immunoglobulin-Based Vector in Myeloma Cells Mediated by Coamplification with a Mutant Dihydrofolate Reductase Gene (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 1271-1274 
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    Notes: [Auszug] We have investigated the feasibility of enhancing expression of an immunoglob-ulin-based vector in myeloma cells by coamplification with a mutant dihydrofo-late reductase (mDHFR) gene. Expression of the vector was monitored by the use of tissue plasminogen activator (t-PA) as a reporter gene. ...
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    Low Frequency Restriction Enzymes in Pulsed Field Electrophoresis (1989)
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    Nature biotechnology 7 (1989), S. 1033-1036 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] Pulsed field electrophoresis (PFE) separates very large DNA fragments—even whole chromosomes. It does this not by the usual gel sieving mechanism, but rather by taking advantage of the size dependence of reorientation times for molecules forced to migrate alternately in two different ...
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    This Workshop Works (1989)
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    Nature biotechnology 7 (1989), S. 871-871 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] What starts off Japanese, emerges half-Canadian, promises to become Latino, and resides in Baltimore? Nova Scotia sushi with summer salsa on a soft roll? An international thriller in which Yokohama detectives join force with Mounties to ferret out South American drug smugglers operating out of the ...
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    Expression of Human β1 and β2 Adrenergic Receptors in E. Coli As a New Tool for Ligand Screening (1989)
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    Nature biotechnology 7 (1989), S. 923-927 
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    Notes: [Auszug] E. coli transformed with appropriate plasmid vectors express human β1 and β2-adrenergic receptors that retain the binding properties of the corresponding receptors in mammalian tissues. The experimental procedure required for pharmacological studies on active receptors expressed in ...
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    Scrabble (1989)
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    Nature biotechnology 7 (1989), S. 845-845 
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    Notes: [Auszug] In the game of Scrabble, the trick is not so much what you know (though that is part of it) or the letters you hold (though that, too, is part of it). The trick is knowing how to develop the board and where to place your most valuable resources for the greatest possible return. That occurred to us ...
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    Regional Development: The Role and Effectiveness of Governmental Agencies (1989)
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    Nature biotechnology 7 (1989), S. 671-683 
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    Notes: [Auszug] In the early 1980s, the national mood concerning the commercial potential of biotechnology was decidedly upbeat. Every region of the country saw itself as the hub of a great new industrial machine, rivalling the success of California and Massachusetts in establishing a high-tech identity. As far ...
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    Comparing the Efficacy of CSFs in Therapy (1989)
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    Nature biotechnology 7 (1989), S. 859-859 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] ORLANDO, Fla.—These are still the early days of immunotherapy, but clinicians and researchers alike respect the fact that they are playing with a new set of rules—even if they don't know what they all are yet. Still, some of the differences between chemotherapy and immunotherapy are ...
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    Japan Roundup (1989)
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    Nature biotechnology 7 (1989), S. 870-870 
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    Notes: [Auszug] Scientists at Kewpie Jyozo Co., Ltd. (Tokyo), working in collaboration with Tokyo Metropolitan University's Katsutoshi Yoshisato, have isolated a novel cell growth and adhesion factor from the membranes that line the inner surface of egg shells. This factor stimulates the growth of cultured human ...
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    Silent Science (1989)
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    Nature biotechnology 7 (1989), S. 534-534 
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    Notes: [Auszug] Injured pride, even in small quantities, is a dubious starting point for a rational discussion of anything. So I have waited several months before telling the story of the scientific meeting I was not permitted to attend—months in which, though the pique has dispersed, my perplexity has grown ...
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    Searle Leaving Its Legacy in the U.K. (1989)
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    Nature biotechnology 7 (1989), S. 547-547 
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    Notes: [Auszug] OXFORD, U.K.—Three years after being taken over by Monsanto (St. Louis, MO) and closing its biotechnology center at High Wycombe, G. D. Searle has established a new research base in the United Kingdom. The company is donating £2.9 million (just under $5 million) toward the cost ...
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    FBI Embracing Genetic Fingerprints (1989)
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    Nature biotechnology 7 (1989), S. 551-551 
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    Notes: [Auszug] WASHINGTON, D.C.—The Federal Bureau of Investigation (FBI) is helping to encourage broader use of DNA analysis by U.S. forensics laboratories. By the end of 1988, the new DNA Analysis Unit of the FBI Laboratory had begun processing forensic evidence and conducting casework associated with ...
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    Looking at Biotech from Down Under (1989)
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    Nature biotechnology 7 (1989), S. 558-558 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] SYDNEY—Australia's ebullient minister of science, Barry Jones, is bullish on bio tech. As well he should be. The push is on to develop—through genetic manipulation—a new wave of high-value-added products and industries in a country that has traditionally relied on primary industry ...
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    Plant Regeneration and Recovery of Fertile Plants from Protoplasts of Maize ( Zea Mays L.) (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 589-594 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] We report plant regeneration from maize (Zea mays L.) protoplasts with recovery of fertile plants from a Cateto inbred line adapted to tropical regions. Protoplasts were isolated from embryogenic cell suspension cultures capable of regenerating fertile plants. Cell colonies and embryogenic calli ...
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    New Assays and Accessories (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 611-612 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Seradyn (Indianapolis, IN) offers large-surface-area latex particles for immobilizing antibodies used in membrane-capture ELISA tests. These particles localize competitive-binding and color-developing reactions on the membrane's top surface. The company also offers polystyrene and ...
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    Of Sound Bites and Biotech (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 624-624 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Abraham Lincoln once said, “With public opinion, nothing can fail. Without it, nothing can succeed.” While he was dealing with a different kind of war, his words also apply to biotechnology's battle against human disease. Companies have, to date, brought to market ten human therapeutic ...
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    Critical Morass (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 397-397 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] So much for strategic alliances. Yes, folks, we've got trouble, right here in biotechnology. That's trouble with a T, which rhymes with C, a C that stands for COCOM. COCOM is a joint coordinating committee of the U.S. Departments of Commerce, State, and Defense. COCOM sees to it that U.S. ...
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    Watson's Great Human Chromosome Auction (1989)
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    Nature biotechnology 7 (1989), S. 559-559 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] WASHINGTON, D.C.—The mammoth project of mapping and sequencing the human genome (Bio/Technology 7:223, Mar. '89) might best be managed by “auctioning off the chromosomes”—perhaps country by country, suggests James Watson, director of the Cold Spring Harbor Laboratory (Cold ...
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    A Prospectus for Multispectral-Multiplex DNA Sequencing (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 576-580 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] First-generation automated DNA sequencers are based on operations, manipulations, and methodologies not unlike those performed by their human predecessors. While these instruments may reduce labor, they do not increase sequencing rates by exponential factors. Here we review several new ...
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    Enzyme Immobilization Using the Cellulose-Binding Domain of a Cellulomonas Fimi Exoglucanase (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 604-607 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] We have constructed a fusion between the gene (abg) for a β-glucosidase (Abg) of an Agrobacterium sp. and part of the gene (cex) for an exoglucanase (Cex) of Cellulomonas fimi. The abg-cex fusion encodes a fusion protein (Abg-CBDCex) with the cellulose-binding properties of Cex and ...
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    Free Literature (1989)
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    Nature biotechnology 7 (1989), S. 617-617 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Pierce Europe (Oud-Beijerland, The Netherlands) introduces its 1989 handbook and general catalog, which lists over 1,000 products for chromatography and immunology. This year's volume includes 230 antibody and detection systems. Write in 701 on Reader Service Card The six-page 1989 price list ...
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    Directing the Genome Project (1989)
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    Nature biotechnology 7 (1989), S. 223-226 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The study of complex genomes, particularly the human genome, is fast becoming the apple pie of U.S. biomedical research. It's hot, and everybody wants a piece. The final Reagan budget request calls for almost $130 million—$100 million for the National Institutes of Health (NIH) ...
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    Pulsed–Field DNA Separations (1989)
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    Nature biotechnology 7 (1989), S. 293-294 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] A primary goal in the human genome project is to construct a physical map of every chromosome. Such a map, constructed by piecing DNA fragments together like a jigsaw puzzle, will guide researchers through the more detailed sequencing tasks to follow as the project picks up steam. The bigger the ...
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    Genentech: Don't Sell the Company Short (1989)
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    Nature biotechnology 7 (1989), S. 114-114 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] SAN FRANCISCO—The tissue plasminogen activator (t-PA) saga has been the Genentech (So. San Francisco, CA) story over the past year. There is more, however, to Genentech's business development strategy. Two announcements made here in January—the planned development and distribution of ...
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    Potatoes Find New Role in Rice Bowl (1989)
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    Nature biotechnology 7 (1989), S. 118-118 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] HO CHI MINH CITY, Vietnam—It's a common cry in Southeast Asia—“We don't have enough rice.” In Vietnam, at least some of this deficit is being met by a new food crop—potatoes. According to Nguyen Van Uyen, a research fellow at this city's Institute for Experimental ...
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    Sensors and Analyzers (1989)
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    Nature biotechnology 7 (1989), S. 177-178 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The Model 80 pressure sensor from IC Sensors (Milpitas, CA) is a media-compatible, solid-state device for measurements in the 5,000 psi range. Combining long-term stability with low cost, the sensor consists of four low-noise piezoresistors configured as a Wheatstone bridge. Resistors vary with ...
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    1990 Funding Uncertain for NIH Effort (1989)
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    Nature biotechnology 7 (1989), S. 1222-1222 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] WASHINGTON, D.C.—The National Institute of General Medical Sciences (NIGMS) of the National Institutes of Health (NIH, Bethesda, MD) recently awarded the first postdoctoral fellowships and predoctoral training grants in the new Chiles biotechnology training program. The program's future ...
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    Passion (1989)
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    Nature biotechnology 7 (1989), S. 1101-1101 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] Rosencrantz: What is your line? Player: Tragedy, sir. Deaths and disclosures, universal and particular, denouements both unexpected and inexorable…flagrante delicto at a price, but that comes under realism, for which there are special terms…It costs little to watch, and a little more ...
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    Immunex Turns a Triple Play (1989)
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    Nature biotechnology 7 (1989), S. 1115-1117 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] NEW YORK—A series of bold strategic moves announced in September by Immunex (Seattle, WA) has left analysts buzzing and the company's stock price inching higher. By reacquiring proprietary rights it previously had traded away to its partners—in particular North American marketing rights ...
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    Sometimes a Great Motion (1989)
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    Nature biotechnology 7 (1989), S. 1121-1122 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Mobile DNA. Edited by D. Berg and M. Howe. Pp. 972. ISBN 1-55581-005-5. $75.00 (American Society for Microbiology, Washington, D.C.: 1989). How does selfish DNA behave? What's today's thinking on the evolution of chromosome structure? How are mutagenic mobile elements regulated? Mobile DNA ...
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    Increased Biomass Production in a Benchtop Fermentor (1989)
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    Nature biotechnology 7 (1989), S. 1178-1181 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Optimization of a fermentation process means different things in different situations. One may optimize for nutrient consumption (as in waste treatment), for product output, or for biomass production. For any of these goals, the main development paths are 1) biological approaches, in which ...
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    Rotary Filtration (1989)
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    Nature biotechnology 7 (1989), S. 1193-1193 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] To the editor: The article on “Downstream Processing” (Bio/Technology 7:777, Aug. '89) correctly identifies the two major problems affecting filter performance—fouling and concentration polarization. The evolution of filtration technology has been towards the solution of these ...
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    Big vs. Little (1989)
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    Nature biotechnology 7 (1989), S. 1248-1248 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] To the editor: You seem to concentrate on the spectacular success stories of transference like Genentech, some of the firms along Route 128 in Boston, or the California companies. How about talking about some of the losers…the little guys who tried it with little or no money and almost made ...
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    Announcements (1989)
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    Nature biotechnology 7 (1989), S. 1194-1194 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] NOVEMBER MEETINGS Nov. 16–19. ASM/SET 3rd Conference on Immunity to Cancer. Williamsburg, VA. Info: Meeting Management, ASM Meetings, 1913 Eye St. N.W., Washington, DC 20006. Nov. 19–21. 1989 Princeton Drug Research Symposia: Myocardial Reperfusion Injury—Novel Therapeutic ...
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    Novo-Nordisk Expands in U.S. (1989)
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    Nature biotechnology 7 (1989), S. 1006-1006 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] Squibb-Novo, the joint venture formed in 1982 between Novo Industri and E, R. Squibb & Sons, has been restructured and renamed Novo-Nordisk Pharmaceuticals. “The joint venture served us well in 1982,” said C. Henk Bleeker, president of the new firm, which will continue to be ...
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    Merged Novo-Nordisk on the Right Course (1989)
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    Nature biotechnology 7 (1989), S. 1006-1006 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] LONDON—Novo-Nordisk (Bagsvaerd, Denmark), the pharmaceuti-cals and biotechnology group formed earlier this year following a merger between Novo Industri and Nordisk Gentofte, has reported its first financial results. The new company achieved a 17-percent increase in sales, to $493 ...
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    Dealing with Large Companies (1989)
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    Nature biotechnology 7 (1989), S. 1013-1019 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] A merger is like a marriage, while a collaboration is closer to cohabitation. Both agreements bring the parties close together, and both can be highly fulfilling. But one route clearly offers more freedom and independence to pursue other interests. While it is up to the parties to decide, case by ...
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    Panel Considers Broadening Its Mandate (1989)
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    Nature biotechnology 7 (1989), S. 1120-1120 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] WASHINGTON, D.C.—During its October meeting, the Recombinant DNA Advisory Committee (NIH-RAC) of the National Institutes of Health (NIH, Bethesda, MD) tentatively recommended changing an essential definition that determines the scope of the committee's activities. The change would ...
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    The Needs for—and of—Biochemical Engineers (1989)
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    Nature biotechnology 7 (1989), S. 1124-1124 
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    Notes: [Auszug] RESEARCH TRIANGLE PARK, N.C.—What do biochemical engineers do? How should a biochemical engineer be educated? In what directions is this emerging field headed, and are these the proper choices for future development? These were some of the questions discussed at a symposium on Initiatives for ...
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    Can Genetically Engineered Crops Become Weeds? (1989)
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    Nature biotechnology 7 (1989), S. 1134-1139 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] What is a hazardous genetically engineered organism? We still don't have the answer to that question. Indeed, opinions vary widely as to what actually constitutes a hazardous—or safe—organism, what the limits of risk are, and what constitutes adequate proof of same1–6. But we do ...
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    Biotech Start-Up Considerations (1989)
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    Nature biotechnology 7 (1989), S. 1030-1031 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] You are in a company or an academic institution and believe that you have a technology that is—or can be—proprietary. Evaluating its potential as the basis of a company is difficult. And you aren't linked to one of those rare venture capital groups that initiate companies based on their ...
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    Recombinant Proteins of Therapeutic Interest Expressed by Lymphoid Cell Lines Derived from Transgenic Mice (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 1049-1054 
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    Notes: [Auszug] As a new approach to produce human proteins of therapeutic interest we have derived lymphoid cell lines expressing such proteins from transgenic mice, either by generating trans-hybridomas by cell fusion in vitro or by onc gene-mediated immortalisation in vivo of transgenic lymphocytes. The latter ...
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    Native Microbes' Role in Alaskan Clean-Up (1989)
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    Nature biotechnology 7 (1989), S. 852-852 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] WASHINGTON, D.C.—Use of microbes to help clean Exxon's (New York, NY) Alaskan oil spill from last March is surely not one of the most dazzling examples of biotechnology, but it may represent one of the largest operations undertaken to date. In August, following pilot studies conducted by U.S. ...
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    Innovations in Image Analysis (1989)
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    Nature biotechnology 7 (1989), S. 954-956 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] Since its invention over 300 years ago, the science of microscopy has seen constant improvements. Its evolution began with improved optics, but these refinements could only go so far. Further advances were made possible by microelectronics and the ability to digitize data, which helped microscopy ...
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    Growth Factors For Wound Healing (1989)
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    Nature biotechnology 7 (1989), S. 793-798 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] The process of wound healing begins immediately following surface lesions or when skin proteins become exposed to radiation, chemical damage or extreme temperatures. Wound repair requires close control of degradative and regenerative processes, involving numerous cell types and complex interactions ...
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