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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Business ethics 3 (1994), S. 0 
    ISSN: 1467-8608
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Philosophy , Economics
    Notes: Managerial effort has been moving from maintaining a “steady state” to wrestling with the challenge of continuing change and the ethical dilemmas which this can present. Is it possible to formulate an “ethics of change” to guide individuals in such circumstances? The author is a senior lecturer at Cranfield University, Bedford MK43 OAL, UK, and a visiting research associate at the London School of Economics. His principal interests concern the management of organisational change in settings where technology is either the key driver of change, or is the key enabler of some aspect of organisational or process redesign.
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  • 2
    Electronic Resource
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    Oxford, UK : Blackwell Publishing Ltd
    Business ethics 3 (1994), S. 0 
    ISSN: 1467-8608
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Philosophy , Economics
    Notes: Stakeholder theory aims at identifying those who have rights or interests at stake in business behaviour. Can we turn the tables and also consider what ethical responsibilities various stakeholders may have for the good behaviour of business? The author is Editor of this Review. This article contains material which also appeared in the Hugh Kay Memorial Lecture for 1993 delivered by the author under the auspices of the Christian Association of Business Executives, London.
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Business ethics 3 (1994), S. 0 
    ISSN: 1467-8608
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Philosophy , Economics
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  • 4
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    Oxford, UK : Blackwell Publishing Ltd
    Business ethics 3 (1994), S. 0 
    ISSN: 1467-8608
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Philosophy , Economics
    Notes: Karl Homann & Franz Blome-Drees (1992). Wirtschafts- und Unternehmensethik. Vandenhoeck & Ruprecht. Göttingen. pp. 207. paperback, 19.80 DM. ISBN 3-8252-1721-3
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  • 5
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    Oxford, UK : Blackwell Publishing Ltd
    Business ethics 3 (1994), S. 0 
    ISSN: 1467-8608
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Philosophy , Economics
    Notes: Brief thumbnail sketches capture group interest and show the relevance of ethical considerations in real life situations. Bill Bain has considerable experience of business and is currently a PhD student at the Management School of London University's Imperial College, 53 Prince's Gate, Exhibition Road, London SW7 2PG.
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  • 6
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    Oxford, UK : Blackwell Publishing Ltd
    Business ethics 3 (1994), S. 0 
    ISSN: 1467-8608
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Philosophy , Economics
    Notes: Games have become a standard tool in management education. The authors have cooperated on developing just such a teaching aid for business people and management students interested in playing the business game ethically. Dr Higginson is Director of The Ridley Hall Foundation, Ridley Hall, Cambridge, CB3 9HG and Geoff Moore is Principal Lecturer at Newcastle Business School, University of Northumbria at Newcastle, Newcastle upon Tyne NE1 8ST.
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  • 7
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    Oxford, UK : Blackwell Publishing Ltd
    Business ethics 3 (1994), S. 0 
    ISSN: 1467-8608
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Philosophy , Economics
    Notes: Despite the social, economic and ethical problems facing government in the Czech Republic, there are positive signs of a growing concern for ethical business, including the development of codes of conduct and a striking example of new corporate social responsibility. Dr Bohatá is a member of the Economics Institute of the Academy of Sciences, Politickych Veznu 7, 111 21 Prague 1, and an Associate Editor of this Review.
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  • 8
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    Oxford, UK : Blackwell Publishing Ltd
    Business ethics 3 (1994), S. 0 
    ISSN: 1467-8608
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Philosophy , Economics
    Notes: The media, advertising and public relations are all regulated in some degree by ethical codes of practice, but do they work and do they help practitioners? The author is Senior Lecturer in public relations and philosophy at Leeds Business School, Leeds Metropolitan University, Leeds LS2 8AF. She is currently preparing material for a new MA in Business Policy and Ethics, to be offered jointly by Leeds Metropolitan University and the University of Leeds.
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  • 9
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    Oxford, UK : Blackwell Publishing Ltd
    Business ethics 3 (1994), S. 0 
    ISSN: 1467-8608
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Philosophy , Economics
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  • 10
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    Oxford, UK : Blackwell Publishing Ltd
    Business ethics 3 (1994), S. 0 
    ISSN: 1467-8608
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Philosophy , Economics
    Notes: Most large frauds develop only gradually and incidentally. When things fall apart it is politic to call it anything but fraud. The author is a member of the Department of Sociology, University of Liverpool, POB 147, Liverpool L69 3BX.
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  • 11
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    Oxford, UK : Blackwell Publishing Ltd
    Business ethics 3 (1994), S. 0 
    ISSN: 1467-8608
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Philosophy , Economics
    Notes: Georges Enderle, Karl Homann, Martin Honecker, Walter Kerber, Horst Steinmann (editors), Lexikon der Wirtschaftsethik. Freiburg im Breisgau, Verlag Herder, 1993. pp. 690, ISBN 3-451-22336-8.
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  • 12
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    Oxford, UK : Blackwell Publishing Ltd
    Business ethics 3 (1994), S. 0 
    ISSN: 1467-8608
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Philosophy , Economics
    Notes: Action needs to be taken on the ethical issues raised by the commercialising of sport if its integrity is to be maintained and its ethical base is not to be eroded further. The author has worked as an independent consultant in the leisure sector for a number of years and has recently joined the Research Unit of Britain's Sports Council. The views expressed by her in this article are not necessarily those held by the Sports Council.
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  • 13
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    Oxford, UK : Blackwell Publishing Ltd
    Business ethics 3 (1994), S. 0 
    ISSN: 1467-8608
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Philosophy , Economics
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  • 14
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    Oxford, UK : Blackwell Publishing Ltd
    Ground water monitoring & remediation 14 (1994), S. 0 
    ISSN: 1745-6592
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Geosciences
    Notes: Hydrogen gas was discovered within the steel casing above standing water in a percussion-drilled borehole on the Hanlord Site in south-central Washington state. In situ measurements of the borehole fluids indicated anoxic, low-Eh (〈-400 mV) conditions. Ground water sampled from adjacent wells in the same formation indicated that the ground water was oxygenated. H2 was generated during percussion drilling, due to the decomposition of borehole waters as a result of aqueous reactions with drilled sediment and steel from the drilling tools or casing. The generation of H2 within percussion-drilled boreholes that extend below the water table may be more common than previously realized. The ambient concentration of H2 produced during drilling was limited by microbial activity within the casing-resident fluids. H2 was generated abiotically in the laboratory, whereby sterilized borehole slurry samples produced 100 times more H2 than unsterilizcd samples. It appears that H2 is metabolized by microorganisms and concentrations might be significantly greater if not for microbial metabolism.
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  • 15
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    Oxford, UK : Blackwell Publishing Ltd
    Ground water monitoring & remediation 14 (1994), S. 0 
    ISSN: 1745-6592
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Geosciences
    Notes: Measurement accuracy was increased by nearly one order of magnitude by outfitting the thermal-pulse flowmeter (TFM) with an inflatable packer. To accurately measure slow water velocities in boreholes greater than 15 cm diameter, it is necessary to divert borehole fluids through the TFM by inflating a packer. During calibration it was noted that the TFM's accuracy decreased as the borehole diameter increased. With Lhe packer inflated the TFM has a useful flow measurement range of 0.08 to 15 L/min (with flow velocities of 0.24 ± 0.012 cm/inin to 45.7 ± 0.61 cm/min, respectively, in 20-cm-diameter pipe), compared to 0.8 to 57 L/min for a packcrless TFM. A computer interlace was added to the TFM to provide a real-time graphical display of the differential voltage output from the TFM, a running mean and standard deviation of the pulse-response time, and a mean flow rate and velocity based on calibration curve fits.
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  • 16
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    Oxford, UK : Blackwell Publishing Ltd
    Ground water monitoring & remediation 14 (1994), S. 0 
    ISSN: 1745-6592
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Geosciences
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  • 17
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    Oxford, UK : Blackwell Publishing Ltd
    Ground water monitoring & remediation 14 (1994), S. 0 
    ISSN: 1745-6592
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Geosciences
    Notes: The Nguyen and Pinder method is one of four techniques commonly used for analysis of response data from slug tests. Limited field research has raised questions about the reliability of the parameter estimates obtained with this method. A theoretical evaluation of this technique reveals that errors were made in the derivation of the analytical solution upon which the technique is based. Simulation and field examples show that the errors result in parameter estimates that can differ from actual values by orders of magnitude. These findings indicate that the Nguyen and Pinder method should no longer be a tool in the repertoire of the field hydrogeologist. If data from a slug test performed in a partially penetrating well in a confined aquifer need to be analyzed, recent work has shown that the Hvorslev method is the best alternative among the commonly used techniques.
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  • 18
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    Oxford, UK : Blackwell Publishing Ltd
    Ground water monitoring & remediation 14 (1994), S. 0 
    ISSN: 1745-6592
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Geosciences
    Notes: Nonparametric prediction limits can be useful statistical tools for ground water monitoring at facilities regulated under RCRA Subtitle C. Subtitle D. and similar regulations. New, exact tables arc presented for both “1 of m” plans (m chances to gel one observation inbounds at each of r monitoring wells to avoid a statistically significant increase) and “California” plans (first or all of the next m-1 observations inbounds at each well). The tables provide per-constituent significance levels (false positive rates) as a function of the background sample size n. m. r, the prediction limit (the largest or the next to largest, background observation), and the confirmatory resampling plan selected.When used in a monitoring program, future observations from several wells are compared with a prediction limit obtained from a common background sample. The table significance levels therefore depend critically on having IID (independent and identically distributed) observations. In particular, the false positive rate computations are not valid, and the procedures should not be used, with constituents whose measurements exhibit inherent spatial or systematic temporal variability.Recent U.S. EPA guidance explicitly encourages controlling facility-wide false positive rates over both constituents and wells. Nonparametric prediction limits, particularly with California resampling plans, will have greater difficulty in meeting the new. lower per-constituent false positive rate goals than previous ones, especially if many constituents are involved. Nonetheless, nonparametric prediction limits remain superior to other commonly used procedures for dealing with data with high proportions of nondctects.
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  • 19
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    Oxford, UK : Blackwell Publishing Ltd
    Ground water monitoring & remediation 14 (1994), S. 0 
    ISSN: 1745-6592
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Geosciences
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  • 20
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    Oxford, UK : Blackwell Publishing Ltd
    Ground water monitoring & remediation 14 (1994), S. 0 
    ISSN: 1745-6592
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Geosciences
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  • 21
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    Oxford, UK : Blackwell Publishing Ltd
    Ground water monitoring & remediation 14 (1994), S. 0 
    ISSN: 1745-6592
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Geosciences
    Notes: On-site analysis of trichloroethylene (TCE) in aqueous samples by head- space sample preparation and gas chromatography (HS/GC) provides for quick and precise concentration estimates. This analytical approach is well suited for the on-site determination of volatile organic compounds (VOCs) in a variety of sample matrices, including ground water and saturated and unsatured soils. For these reasons, HS/GC can be used to establish analyte concentrations on a near real time basis to help select appropriate casing material during monitoring well installation. This application and the collection of multiple well samples during sampling events facilitates the hydrogeological site interpretation and the formulation of remediation strategies.
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  • 22
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    Oxford, UK : Blackwell Publishing Ltd
    Ground water monitoring & remediation 14 (1994), S. 0 
    ISSN: 1745-6592
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Geosciences
    Notes: The vertical distribution and partitioning (between the solid and aqueous phase) of chromium in a glaciofluvial aquifer in northeastern Connecticut were assessed. Most of the chromium (99 percent of its mass) is bound to the soil. Retardation is primarily the result of binding to organic matter and adsorption to iron oxide coatings. However, other attenuation mechanisms also appear to be significant. If the degree of chromium binding observed here is representative of other chromium contaminated sites, pump-and-treat remediation will not remove the vast amount of chromium from the subsurface. However, most of the chromium may be immobile, and removal may not be required following the initial pumping to remove the mobile fraction. Further knowledge of the mechanisms that bind chromium to the soil, their reversibility, and their kinetics is essential to developing effective remediation strategies.
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  • 23
    ISSN: 1745-6592
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Geosciences
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  • 24
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    Oxford, UK : Blackwell Publishing Ltd
    Ground water monitoring & remediation 14 (1994), S. 0 
    ISSN: 1745-6592
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Geosciences
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  • 25
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    Oxford, UK : Blackwell Publishing Ltd
    Ground water monitoring & remediation 14 (1994), S. 0 
    ISSN: 1745-6592
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Geosciences
    Notes: Surfactant solutions are being proposed for in situ flushing of organic contaminants from soils and aquifers. The feasibility of surfactant additives in remediation may depend in large part on how these chemicals affect the hydraulic conductivity of the porous media. While there is evidence in the literature of conductivity loss during surfactant flushing (Miller et al. 1975; Nash et al. 1987), there has been little research on quantifying the process for unconsolidated sediments. Surfactant-affected hydraulic conductivity reductions were measured in two soils (Teller loam and Daugherty sand). Testing was done with eight surfactants at a variety of concentrations (10-5 to 10-l mole/kg), surfactant mixtures, and added solution electrolytes. The Teller was also tested with its organic matter removed. Maximum hydraulic conductivity decreases were 47 percent for the sand and more than two orders of magnitude for the loam. Surfactant concentrations, surfactant mixtures, soil organic content, and added solution electrolytes all affected the degree of conductivity reduction. Results indicate that surfactant-affected hydraulic conductivity losses should be considered prior to in situ remediation and may preclude surfactant use in some fine grain soils.
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  • 26
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    Ground water monitoring & remediation 14 (1994), S. 0 
    ISSN: 1745-6592
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Geosciences
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  • 27
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    Oxford, UK : Blackwell Publishing Ltd
    Ground water monitoring & remediation 14 (1994), S. 0 
    ISSN: 1745-6592
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Geosciences
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  • 28
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    Oxford, UK : Blackwell Publishing Ltd
    Ground water monitoring & remediation 14 (1994), S. 0 
    ISSN: 1745-6592
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Geosciences
    Notes: Soil gas samples from intact soil cores were collected on adsorbents at a field site, then thermally desorbed and analyzed by laboratory gas chromatography (GC). Vertical concentration profiles of predominant vapor phase petroleum hydrocarbons under ambient conditions were obtained for the zone directly above the capillary fringe. Water and residual phase weathered aviation gasoline were present in this region of the profile.The sampling, trapping, and GC methodology was effective in most respects. Reproducibility, trapping, and desorption efficiency were generally satisfactory, and different sorbent tubes gave similar results. A minor shortcoming of the method occurred with the most volatile compound, 2,3-dimcthylbutane, which was poorly retained during several weeks of storage lime and was also poorly desorbed.Vapor phase concentrations of predominant hydrocarbon compounds all increased with depth at one sampling location. At a more highly contaminated location, concentrations of highly volatile compounds increased with depth while concentrations of less volatile compounds remained constant or decreased, possibly indicating distillation effects. Scatier in the data was attributed to heterogeneities in water and residual phase distribution.
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  • 29
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    International journal of immunogenetics 21 (1994), S. 0 
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Many new Major Histocompatibility Complex (MHC) genes have been discovered in the last 5 years. Defining the polymorphism of these new genes may elucidate their function and their relevance to diseases with MHC associations. Polymerase chain reaction and single stranded conformation polymorphism (PCR SSCP) analyses were used to detect sequence polymorphisms of PERB1 demonstrated by comparing the available genomic sequence of four haplotypes. This study showed that PCR SSCP of PERB 1 is reproducible. In addition, PERB1 alleles segregate within families together with MHC haplotypes. Typing results from the Forth Asia and Oceania Histocompatibility Workshop (4AOHW) cell panel indicate that the identified polymorphisms of PERB 1 are ‘haplotypic’, i.e., unrelated individuals carrying the same MHC ancestral haplotypes carry the same PERB1 SSCP pattern. Interestingly, PERB1 SSCP patterns allow the distinction of ancestral haplotypes which share HLA-B serological specificities, such as HLA-B44 and therefore this analysis can be used to further define MHC haplotypes and thus to improve our understanding of the evolution of this complex.
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  • 30
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Twenty-eight cases of coeliac disease (CD) and seven of dermatitis herpetiformis (DH) have been verified in Iceland. Standard serological techniques were used for HLA typing. Twenty-five individuals with CD were typed, 21 (84%) of whom carried DR3, DQ2. Twelve of these 25 (48%) had DR3, DR7, DQ2, which makes them possibly homozygous for DQ2, and suggests that homozygosity of DQ2 increases the risk for CD. The four DH patients that were typed all had HLA-B8, DR3, DQ2. It is concluded that CD and DH are associated with DR3, DQZ in Icelanders.
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  • 31
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    International journal of immunogenetics 21 (1994), S. 0 
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: In order to identify new susceptibility markers for Rheumatoid Arthritis (RA), we analysed the dinucleotide repeat polymorphism at the T cell receptor delta locus (TCRD) in 65 RA patients and 99 healthy Belgian controls. A significant under-representation of the A4-A5 TCRD genotype was observed in the RA population.
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  • 32
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    International journal of immunogenetics 21 (1994), S. 0 
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
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  • 33
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    International journal of immunogenetics 21 (1994), S. 0 
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: HLA antigens of the Kuwaiti population are not as well characterized as those of other international ethnic groups. We present results for HLA typing of Kuwaiti individuals using commercial Biotest sera. Six hundred and seventy one Kuwaiti were typed for HLA-A, -B, -C antigens and 399 were typed for HLA-DR, -DQ antigens. Antigen frequency and gene frequency were computed for each phenotype observed. The antigens with the highest frequencies were HLA-A2, A1 and A3; B5, B12 and B7; Cw″4 and Cw-l; DR52, DR5, DR3 and DR7; DQ1 and DQ2. HLA haplotypes with strong linkage disequilibrium and characteristic of Kuwaiti population are A2-B5, A1-B8, B7-DR7 and B8-DR3. A comparison study with other populations is presented.
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  • 34
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    International journal of immunogenetics 21 (1994), S. 0 
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: HLA-B14 positive haplotypes have increased frequencies in a group of patients with puberty disorders, IgA deficiency and cancer of the ovary. Clinical investigations demonstrated that all these patients have high values of 170H progesteron after the ACTH test which suggests an alterated function of 21 hydroxylase enzyme. In order to investigate whether these B14 positive haplotypes carry the same CYP21 mutation in the various diseases and controls, we have amplified by polymerase chain reaction (PCR) the sections of CYP21B gene which include amino acid positions 172 and 281 where typical mutations are known to occur in 21 hydroxylase deficiency. The presence or absence of the defined mutations was tested by oligonucleotide hybridization using oligonucleotides, labelled with DIG-ddUTP, designed to hybridize with the mutated or with the normal sequence. It was found that regardless of whether the subject tested was a patient or a healthy control the mutation at position 281 was found in all cases carrying HLA-B14, DR1 haplotype. Interestingly, this mutation does not seem to be in association with HLA-B14, DR7 haplotype.These findings suggest that CYP21 gene plays a role in all these differing diseases although it must be stressed that there may be alternative explanations for the observed data.
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    International journal of immunogenetics 21 (1994), S. 0 
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Patients with CAH, extrahepatic HBV manifestation and healthy children were studied for presence of Gm 1,2,3,10,21 factors and Km 1 factor. Significantly higher frequency of Gm (1, 2, 3, 10, 21) phenotype was shown in CAH group as compared with the other two groups. Relationship between Km factors and examined groups was not found.
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  • 36
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    International journal of immunogenetics 21 (1994), S. 0 
    ISSN: 1744-313X
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    Topics: Biology , Medicine
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  • 37
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    International journal of immunogenetics 21 (1994), S. 0 
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: HLA-DRB1, DQA1 and DQB1 alleles have been determined in 42 families with one IDDM proband and 64 healthy controls, by oligotyping (PCR-SSO) using primers and probes from the XI International Histocompatibility Workshop. A positive DRB1 *03 and DRB1 *04 association with the disease was observed, whereas DRB 1*11 and DRB 1 *07 showed negative association but 19% of patients carried DRB1 alleles different to DRB 1 *03 or *04. When single alleles were considered, DQA1 *03 showed the strongest association with susceptibility to the disease (RR = 8.2, Pc = 0.00001) but this association was outgrown by 2 and 3 allele combinations, with genotype DRB 1 *04-DQA 1 *03-DQB1*0302/DRB1*03- DQA 1*0501- DQB 1*0201 showing the strongest association (RR = 28, Pc = 0.002). Application of the relative predispositional effect (RPE) method to our data, revealed a further susceptibility risk provided by the DRB1*13-DQA1*0102-DQB 1*0604 haplotype once DR3 and DR4 haplotypes were removed. When DQA1-DQB1 genotypes were analysed for presence of Arg 52 (DQ α) and absence of Asp 57 (DQ β), genotypes SS/SS were found significantly increased in diabetics. Interestingly, one of the strongest associations with the disease was observed with the DQA 1*03-DQB 1*0201 combination encoded mainly by genes in trans (RR = 11.7 Pc = 0.00004). These observations and their comparison with DR-DQ haplotypes in more homogeneous ethnic groups support the stronger influence of the DQ molecule rather than the individual DR or DQ alleles in the susceptibility to IDDM. They also emphasize the need for detailed HLA haplotype studies in non-Caucasian and ethnically mixed populations to gain further insight into the nature of genetic and environmental factors contribution to autoimmunity.
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  • 38
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    International journal of immunogenetics 21 (1994), S. 0 
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: The human TNF genes are located within the MHC class-III region on chromosome 6. The presence or absence of an Nco-I restriction site in the 5’ non-coding sequence of the TNFβ gene defines two alleles (TNFB*1 and TNFB*2). The segregation of these alleles has been associated with levels of TNFα or TNFβ production in systemic lupus erythematosis (SLE), insulin-dependent diabetes mellitus (IDDM) and in healthy control individuals.Rheumatoid arthritis (RA) is characterized by high levels of TNFα within the synovial fluid and to address the question of whether this could be brought about by a genetic predisposition to high TNF production by RA individuals, we examined the distribution of this Nco-I polymorphism in 98 healthy volunteers and 123 patients with active rheumatoid arthritis. No difference was observed between the normal and RA groups with respect to haplotype segregation or allelic frequency. Furthermore, no difference was observed between DR4+ or DR4- individuals in the control or RA groups.These data demonstrate that the high level of TNFα seen in the joints of RA patients is unlikely to be due to a genetic predisposition of these patients to high TNFα production, as defined by the TNF Nco-I restriction fragment length polymorphism (RFLP).
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    International journal of immunogenetics 21 (1994), S. 0 
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    Topics: Biology , Medicine
    Notes: The exceptionally strong independent association found between Lp(a) lipoprotein [Lp(a)] levels and atherosclerotic disorders indicate that Lp(a) is a factor of considerable importance in the pathogenesis of atherosclerosis. The association between Lp(a) and diabetes, rheumatoid arthritis and renal diseases suggest that Lp(a) may be involved in immunological mechanisms.Lp(a) has a great tendency to aggregate and bind to glucosaminoglycans, fibrin and fibronectin and is preferentially retained in the extracellular matrix during development of atherosclerosis and is in vitro phagocytosed by macrophages, probably as small aggregates. It was previously found that the Lp(a) level is significantly related to the HLA class II genotype in male patients with early coronary artery disease. In this paper additional results of interleukin determinations in relation to HLA type and Lp(a) levels are presented and discussed. It is suggested that an autoimmune process, perhaps triggered by a concomitant intracellular infection may occur, especially in patients with inherited high Lp(a) levels in combination with certain inherited HLA class II genotypes.
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    International journal of immunogenetics 21 (1994), S. 0 
    ISSN: 1744-313X
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    Topics: Biology , Medicine
    Notes: DPB1 locus typing of the 155 cell 4AOHW panel was performed using a PCR-RFLP method. Ambiguity of allele assignment was resolved by amplification using sequence-specific primers. Of the 150 cells for which typings were achieved, three exhibited unusual restriction enzyme fragment patterns, suggesting the possibility of novel DPB1 alleles. Sequence analysis revealed one allele present in the currently reported 46, one novel allele (4AOHW/107) not present among the 46, and one from a non-human primate which is being investigated. Twenty-six (26) of the 34 10IHW cells have been studied previously by cDNA RFLP, and strong haplotypic associations have been demonstrated between DPA1 and DPB1 locus alleles. It is proposed that exploitation of intron polymorphisms marking haplotypes will be an integral part of future DPB 1 typing as a ‘first-pass’ stratification process to minimize the requirement for sequence-based methods to definitively assign DPB 1 alleles.
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    International journal of immunogenetics 21 (1994), S. 0 
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    Topics: Biology , Medicine
    Notes: DNA oligotyping was used to determine HLA-A28 subtypes in 25 unrelated Caucasian individuals living in or around Seville, Spain. Results showed that HLA-A*6802 was the most frequent allele, found in 14 individuals (53.8%), followed by HLA-68.3, which was present in eight subjects (30.8%), and both combined represented 84.6% of A28+ individuals in the area. The HLA-A*6801 allele was found in three individuals (11.5%), whereas HLA-A*6901 was present in one subject only (3.8%). Results indicate that the distribution of HLA-A28 alleles can vary among different Caucasoid populations. In this way, the high frequency obtained for A*6802 supports previous studies suggesting that the HLA-A*6802 allele was prevalent in people of the Mediterranean basin, in contrast to A*6801, prevalent in northern European populations.
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    International journal of immunogenetics 21 (1994), S. 0 
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    International journal of immunogenetics 21 (1994), S. 0 
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    Topics: Biology , Medicine
    Notes: HLA alleles were studied in Kuwaiti patients with Systemic lupus erythematosus (SLE). Although significant association of B5, B8, and DR3 has been reported in the literature, the most common phenotype for our patients is A3, DR2 as susceptible alleles and DQ1 as a protective gene.
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    International journal of immunogenetics 21 (1994), S. 0 
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    Topics: Biology , Medicine
    Notes: A new HLA-B antigen, HLA-B7Qui that appears to be a variant of HLA-B7 has been identified. This antigen, which is HLA-Bw6 associated, reacts with approximately two-thirds of cytotoxic antisera stimulated by HLA-B7 or B27 that lack a B27 or B7 component, respectively. All anti-B7+27 antisera (stimulated by either B7 or B27) react with B7Qui as do most B22-stimulated sera possessing a B7 component. However, sera stimulated by B60, with or without a B7 component, fail to react with B7Qui.Family studies show the B7Qui allele to be unique to the haplotype –HLA-A32 CW6 B7Qui Bf*S C4A*6 C4B*1 DR11 DQ7 (GL02). Six Caucasoid subjects on the panel of 6861 HLA-typed potential bone marrow donors have this antigen (phenotype frequency, 0.08745%; gene frequency, 0.04473%). Work undertaken during the 11th International Histocompatibility Workshop (Reekers et al., 1992) showed that B7Qui has the same isoelectric point as HLA-B702 and HLA-B703 (Bpot) and that B7Qui is distinct from the HLA-B7 variants B703, B7SL, BDT, B7x40, BRI, and B41v.
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  • 46
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    International journal of immunogenetics 21 (1994), S. 0 
    ISSN: 1744-313X
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    Topics: Biology , Medicine
    Notes: HLA-DRB1*04 allele frequencies have been determined in 184 HLA-DR4-positive unrelated blood donors from the South Wales area, using group-specific polymerase chain reaction (PCR) amplification and hybridization with sequence-specific oligonucleotide probes, PCR amplification with sequence-specific primers, and PCR single-strand conformation polymorphism analysis.Eight of the fifteen known HLA-DR4 sequences were detected in this study. Linkage disequilibrium analysis of HLA-DRB1 *04 and HLA-B, -DR and -DQ alleles revealed distinct haplotypic associations for all the major alleles detected in this population, including the novel linkage of HLA-B55 with DRB1*0407.These results are relevant to the role of HLA-DRB 1*04 haplotypes in determining allogeneic histocompatibility and disease susceptibility.
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    International journal of immunogenetics 21 (1994), S. 0 
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    Topics: Biology , Medicine
    Notes: A chicken MHC class I (B-F) cDNA from SPAFAS line 11 embryonic liver tissue was isolated and characterized by nucleotide sequencing. Comparing this sequence with previously described B-FcDNAs highlights clustered nucleotide substitutions in exon 3, encoding amino acids located on the a-helical region of the α2 domain.
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    Water and environment journal 8 (1994), S. 0 
    ISSN: 1747-6593
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    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: The Sankey Brook catchment lies in the heart of the Mersey basin. As part of a major study into development issues in the Sankey Brook catchment, a hydraulic model was constructed and successfully used to simulate the river system and to assist in the derivation of discharge control policies.The background to the study and the subsequent hydrological and hydraulic modelling are described, particularly in relation to the more complex systems in the lower reaches of Sankey Brook.
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    Water and environment journal 8 (1994), S. 0 
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    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Osaka has nearly completed its sewerage system, and twelve sewage-treatment works are now in operation. Tsumori and Ebie works, the two oldest, were commissioned in 1940. For these works, full-scale reconstruction has just commenced.This paper reports on the reconstruction of the Tsumori works, and outlines the plan for future reconstruction of the city's sewage-treatment works.
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    Water and environment journal 8 (1994), S. 0 
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    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: The paper outlines how consent standards are normally calculated in Scotland for both river systems and tidal waters. A background is given to the reason why a more statistical approach has been adopted in England and Wales where the use of combining distribution methods is more widespread. Comparison of the two approaches is made, particularly with regard to their potential impact on resources required for treatment plants, and also the problems of taking enforcement action. The setting of standards under the EC urban waste water treatment Directive is considered where, in addition to the implications of primary, secondary and more stringent treatment, consideration is given to storm-sewage overflows and industrial discharges.
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    Water and environment journal 8 (1994), S. 0 
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    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: The introduction of ultraviolet disinfection in Jersey has achieved significant improvements in water quality. However, bathing waters in St Aubin's Bay and shellfish flesh have failed to comply with microbial standards. Streams and seepages from coastal structures were investigated as potential indicator organism sources (total and faecal coliforms, faecal streptococci). Seepages were an unimportant bacterial source as concentrations were low. Geometric mean concentrations in streams were up to four orders of magnitude higher than in final sewage-treatment works effluent, and concentrations increased significantly at high stream discharge. Rainfall-induced pulses of poor water quality occurred two to three times per week during the 1993 summer season. Natural discharges from island catchments thus contribute significantly to the bacterial load received at the coast, especially during high flow events. These observations have implications for other UK and European schemes using tertiary disinfection technology to attain water quality targets in coastal waters.
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    Water and environment journal 8 (1994), S. 0 
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    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: British Gas owns over 900 sites within the UK with a total land area in excess of 5500 ha. Many of the sites are former gasworks, chemical works or associated holder stations.Although serious attempts were made to remove contamination during the last three decades, the operating and demolition standards previously considered to be adequate may no longer be acceptable and may have given rise to sites with the potential to contaminate adjacent land, surface waters and ground-water. As a result, further actions may now be required on these sites to reach new environmental standards, thereby reducing any chance there may be of legal liability on the Company.This paper describes the advantages and disadvantages of several qualitative and quantitative risk-assessment methods which can be used to prioritize potentially contaminated sites for further investigation. The use of site investigation data to accurately target risk reduction in site remediation proposals is also discussed.
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    Water and environment journal 8 (1994), S. 0 
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    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Using regional statistics of daily rainfall, a simple water-balance model was employed to generate runoff sequences with which to simulate the yield/storage behaviour of reservoirs in south-east England, in north-west England, and North Wales. Similarly sequences of recharge to an unconfined aquifer in eastern England were the basis of deriving its yield/storage behaviour. Then, taking scenarios of the year 2030 rainfall and evaporation, provided by the University of East Anglia's Climatic Research Unit, reductions in yield were calculated to be 5–15% below present-day values. For direct supply reservoirs, greater percentage reductions in yield were found to apply to the south-east region, as compared to the north-west. The results from the aquifer example are interpreted on a novel basis which allows an immediate comparison with the surface reservoir examples.Coastal sea-water intrusion was modelled for three common geological conditions (i) the Grimsby Chalk (confined), (ii) the Brighton Chalk (unconfined), and (hi) the Otter Valley Sandstone (unconfined). In all three cases the effect of a possible 0.6 m rise in mean sea level was shown to have only a marginal effect on sustainable yields, which reduced by about 1.5%.Estuarine fresh-salt water interfaces are important to the abstraction regime of freshwater intakes in the lower reaches of rivers. The effect of a 0.6-m sea-level rise on the saline interface location at high tide was evaluated by hydrodynamic computational models. Only a minor inland shin of the interface was found, less man 800 m in the Thames tideway and less than 500 m in the Lune estuary. The Severn estuary is exceptional in having its saline interface move 3.5 km landwards for the same 0.6-m rise in mean sea level.
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    Water and environment journal 8 (1994), S. 0 
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    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: During the long-distance pressure transportation of sewage, the interior of a rising main tends to become anaerobic, thereby producing a large amount of hydrogen sulphide at manholes and terminals. High concentrations of hydrogen sulphide have become a serious environmental and maintenance problem.In order to prevent the production of hydrogen sulphide in rising mains, the City of Kobe (in Japan) introduced a system to inject air directly into the main.This paper describes the results of studies on the effect of air injection on hydrogen sulphide inhibition and the relationship between water quality and the amount of air injected.
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    Water and environment journal 8 (1994), S. 0 
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    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: This paper describes the experience gained by Yorkshire Water in the construction and operation of a wastewater treatment plant to deal with the effluent from Europe's largest canning and bottling factory (at Wakefield, West Yorkshire). The process which was chosen was the ‘Biothane’ upward-flow anaerobic sludge blanket system. Commissioning of the plant was fraught with difficulties due to the erratic organic load being discharged from the factory, along with larger than anticipated volumes of caustic solution.
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    Water and environment journal 8 (1994), S. 0 
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    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: The problems of water-colour management in peatland catchments are discussed. Colour may be managed in three areas of the reservoir catchment system: on the catchment itself, in the channel/conduit system and within the reservoir. Whilst a number of workers have considered the management of catchment areas and some have evolved tributary turnout strategies, no previous research has considered the role of the reservoir in the amelioration or enhancement of water colour. The management of water colour at Thornton Moor catchment (near Bradford) is described. In this catchment a staged approach has been adopted, with colour being managed in an integrated manner at three stages along the catchment/conduit/reservoir system.
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    Water and environment journal 8 (1994), S. 0 
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    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Books reviewed in this article: Water Wisdom, by Colin Allsebrook. Regional Ground-Water Quality. Edited by W. M. Alley. Respirometry of Activated Sludge, by Milenko Ros. Strategy for the Sustainable Use of England's Estuaries, by English Nature. European Environmental Law Casebook, by L. Krämer.
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    Water and environment journal 8 (1994), S. 0 
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    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Stream gauging data play a vital role in the planning of flood mitigation strategies. A study of the value of stream flow data for the design of levee systems shows that the availability of a reasonable sample of pertinent data can be worth many times the cost of collecting that data.
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    Water and environment journal 8 (1994), S. 0 
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    Water and environment journal 8 (1994), S. 0 
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    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: In 1985 the House of Commons Environment Committee expressed reservations over some of the waste-management procedures followed by British Nuclear Fuels Ltd at their Drigg low-level radioactive waste disposal facility near Sellafield in Cumbria. These reservations prompted the company to implement a £20 million programme of improvements aimed at maximizing site usage, reducing trench leachate arisings and redirecting to the Irish Sea.This paper provides information and test results associated with design considerations and initial dilution testing, respectively, of a computercontrolled long sea outfall system designed to discharge leachate to the Irish Sea. Information is also provided on difficulties experienced during construction of the outfall.
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    Water and environment journal 8 (1994), S. 0 
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    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Since 1987 British Gas plc has undertaken an extensive programme of medium pressure (up to 2 bar) cast-iron mains replacement in urban locations, using a variety of rehabilitation techniques.This paper describes the experience of North Thames Region of British Gas plc, over the period 1987–1991, when the rehabilitation of over 230 km of mains was undertaken in the size range 300–460 mm.The techniques which were used favoured medium density polyethylene pipe wherever possible. However, about 100 km of rehabilitation was undertaken using hoselining, usually where mains were larger than 460 mm dia., or where aboveground access was restricted, or if the mains configuration included many changes of direction.This paper deals with (a) various aspects of operating rehabilitation contracts from a public utilities viewpoint, (b) the special factors relating to the inspection and testing of hoselined mains including factors found to contribute to failure, and (c) some of the controls that have been introduced to improve reliability of rehabilitation systems.
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    Water and environment journal 8 (1994), S. 0 
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    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: The use of cement kilns for managing solid and hazardous wastes is facilitated by the high temperature, long gas retention periods, natural alkaline environment, minimum amount of waste produced and high thermal capacity. The main benefits include energy recovery, conservation of fossil fuels, reduction in cement production costs and the use of already existing facilities.The test burns conducted in cement kilns worldwide have demonstrated very high destruction efficiencies for most stable organic compounds, with toxic contaminants barely above the background levels.There are several cement plants in the US and Europe presently using solid and hazardous wastes as supplementary fuel. The application of this technology in Australia has been ignored in the past. An international conference (Kilnburn‘92) on the role of cement kilns in waste management was held recently in Australia and has enhanced the implementation of this technology in Australia.
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    Water and environment journal 8 (1994), S. 0 
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    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: The capacity of the sewage-treatment works at Silchester in Hampshire has been enhanced and the effluent quality improved to a high standard by the installation of a new submerged biological aerated filter plant. Ten prefabricated steel submerged aerated filters reduce BOD and fully nitrify settled domestic sewage from a population equivalent of 20 000.Comprehensive operating data are presented to demonstrate the ability of single-stage submerged downflow aerated biological filters to produce a nitrified effluent. The final effluent quality remains consistently within consent limits at 4.8 mg/l BOD, 7.0 mg/l SS and 0.5 mg/l NH3-N, all 95 percentiles. (Consent 7 mg/l BOD, 25 mg/l SS, and 5 mg/l NH3-N, 95 percentiles.)Data are presented on total coliform and E. Coli concentrations through the filter plant, showing better than 3 log reductions in the effluent.
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    Water and environment journal 8 (1994), S. 0 
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    Notes: In recent years an increase in the eutrophication of reservoirs has added to the problems of lowland surface-water treatment. A pilot plant was installed to test the effectiveness of various treatment regimes for a river source which was subject to occasional algal blooms, and a eutrophic reservoir source which was heavily contaminated with cyanobacteria (Oscillatoria sp.). The treatment processes adopted were dissolved-air flotation for chemical coagulation, sand and anthracite filtration, comparative disinfection stages using ozone and chlorine followed by granular activated carbon filtration.The dissolved-air flotation plant was not particularly effective for the removal of algae, but the sand/anthracite filtration process was capable of removing 50% of the algae. The ozone disinfection stage was adequate for disinfection and also reduced algal numbers. Overall the chlorine/granular activated carbon method did not perform as effectively as the ozone/granular activated carbon process; the iatter process was +99% effective for algai control, with river and reservoir sources.
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    Water and environment journal 8 (1994), S. 0 
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    Notes: An intermittent strong vegetable/cabbage odour was noted on raw water abstracted from the River Dee (NW England). The source of the odour was traced to an industrial discharge from an animal feed manufacturer to a tributary of the River Dee. Analysis of water samples by CLSA GC-MS revealed the likely causes of the odour to be dimethyl disulphide and dimethyl trisulphide. 2-hydroxy-4-(methylthio)butanoic acid (HMB), a hydroxy methionine analogue growth supplement used by the feed manufacturer was a likely precursor to the odour problem. Studies conducted on the behaviour of HMB in untreated water showed it to be rapidly degraded. Degradation products included dimethyl disulphide, dimethyl trisulphide and methyl(methylthio)methyl disulphide. The odour of water samples incubated with HMB changed from that of potato to cabbage/sprout, indicating that breakdown of this compound was responsible for the vegetable odour on untreated river water.
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    Business ethics 3 (1994), S. 0 
    ISSN: 1467-8608
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Philosophy , Economics
    Notes: “There are strong temptations for those at the top of an organisational hierarchy to appropriate to themselves a disproportionate share of the resources of the organisation and to exercise too much power over the activities of other organisational members.” Hence the case for taking a cool look at executive remuneration and other possible breaches of applying the classical virtue of temperance to corporate behaviour. The author is Principal Lecturer in the Business Studies Department, Manchester Metropolitan University, Aytoun Building, Aytoun Street, Manchester M1 3GH.
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    Notes: “Discrimination on the grounds of disability is seldom malicious, but stems more from a lack of understanding.” A disabled businessman explores the need for businesses to cultivate and implement greater disability awareness. After graduating in engineering, he gained his MBA from London Business School in 1992. He now works as a consultant, capitalising on his background in business management and his personal experience of disability to assist clients in developing anti-discriminatory policies and practice.
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    Notes: Once a company has identified its core values role play can help its leaders explore their meaning in practice. The author is now working as a freelance adviser on organisation development having worked in this area in a large engineering company. He has a general interest in the industry/church interface.
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    Notes: Case studies invite students to share in an ethical dilemma and challenge them about their values. Dr Sheldrake is Reader in Modern History at London Guildhall University, Old Castle St., London E1 7NT. A version of his case study appeared in Sarah Vickerstaff (Ed.), 1992, Human Resource Management in Europe: Text and Cases, London: Chapman & Hall.
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    Notes: ’Those who understand the underlying technology on which the modern business depends have a professional, social and moral obligation to look to the needs of their neighbours who lack that understanding’. Professor Ennals is a member of the Business Information Technology Research Unit of Kingston Business School, Kingston University, Kingston-on-Thames KT2 7LB, England, where he has shared in developing the new Business Information Technology degree.
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    Notes: Last October the Director-General of the Confederation of British Industry delivered the annual Gresham Special Lecture in Gresham College in the City of London, in which he considered ways of developing a closer and potentially more fruitful relationship between the City and the UK manufacturing industry. The lecture is here reproduced with permission.
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    Notes: European direct investment in the USA raises many local concerns. Are these concerns justified, or alleviated, by the way in which different European companies exercise corporate citizenship in the host country? The author is Assistant Professor of Strategic Management at the College of Business Administration, University of Oklahoma, 307 West Brooks, Norman, Oklahoma 73019-0450, USA.
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    Notes: An initial review of the Draft Guidance produced in response to the Cadbury Report by the Institute of Chartered Accountants in England and Wales. The author is Principal Consultant, Corporate Social Responsibility Consultants, 86 Iffley Road, London W6 OPF.
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    Notes: How common are corporate codes of ethics in the UK and especially among Britain's most admired companies? The author is Wicklander Professor of Professional Ethics at DePaul University, Chicago, and current President of the American Society for Business Ethics.
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    Notes: Dramatic economic developments have served to highlight ethical questions and responses within business life in Finland, particularly regarding the crisis of the Finnish banking system. Other issues which have aroused public discussion are maintaining the natural biodiversity in the Northern hemisphere forests, and Finland's trade with Russia. The authors, listed alphabetically, are all research fellows at the School of Business Administration in the University of Tampere, PO Box 607, 33101 Tampere,Finland.
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    Notes: “The potential dangers of ignoring ethical issues exist for all business computer professionals”. Drs Langford and Wusteman, of the Computing Laboratory, The University, Canterbury, Kent CT2 7NF, reflect on their experience of teaching ethics to computer scientists and on the problems to be encountered in this new field of applied ethics.
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    Notes: Book reviewed in this articleDavid BarkerJames O'Toole, The Executive's Compass: Business & The Good Society.
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    Notes: Interesting contrasts and parallels on ethical issues emerge from a recent series of in-depth interviews given by managers in nine companies operating in Europe. The author is Professor of Marketing at the University of Notre Dame, Indiana 46556, USA, on leave during 1993-94 as Visiting Professor in the Department of Management and Marketing, University College Cork, Ireland. He wishes to acknowledge the financial assistance of the College of Business Administration at the University of Notre Dame in supporting this research.
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    Notes: A philosopher looks at the scepticism of some of her colleagues about just what the study of ethics can contribute to ethical business, and argues that its main purpose is to help business people to engage in constructive ethical dialogue in society as well as in their corporation. The author is a regular contributor to this Review, and Director of the Centre for Business and Professional Ethics, University of Leeds, Leeds LS2 9JT.
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    Notes: Teaching business ethics to undergraduates has disclosed difficulties for both students and teacher which raise deeper issues about what is the purpose of teaching ethics and of engaging in business. The author is Lecturer in Business Ethics in the Faculty of Business and Social Studies, Cheltenham & Gloucester College of Higher Education, Swindon Road, Cheltenham, Glos GL50 4AZ, UK.
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    Notes: The Ecole Supérieure de Commerce de Rennes has recently introduced a final year group-taught compulsory course in Business Ethics. Its organisers here describe and discuss their aims, methods and results. Michael Brent is Head of the Human Resources Department at Groupe ESC Rennes, 2 rue Robert-d’Arbrissel, 35065 Rennes, and has an MA in Philosophy and diplomas in business and marketing, as well as several years European consultancy experience. Susan Grinsted teaches production management and related subjects at Rennes, with a first degree in Metallurgy and a PhD in Engineering as well as several years UK industrial experience and a previous appointment at Warwick University, England.
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    Notes: Australia too is witnessing a growing interest in business ethics. Dr Longstaff, Executive Director of the St James Ethics Centre in Sydney, explores how directors should play an active part in developing ethical business.
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    Notes: Mike Savage & Anne Witz, eds., Gender and Bureaucracy, Blackwells, Oxford, 1992, pp. 282, pb, £13.99, ISBN: 0631-85283.
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    Notes: Adrian Furnham, The Protestant Work Ethic. The Psychology of Work-related Beliefs and Behaviour, Routledge, Chapman & Hall, London and New York, 1990, pp. xv + 305, pb, £13.99, ISBN 0-425-01705-X.Carl-Henric Grenholm, Protestant Work Ethics: A Study of Work Ethical Theories in Contemporary Protestant Theology, Uppsala Studies in Social Ethics 15, Uppsala, 1993, pp. 350, np.
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    Risk analysis 14 (1994), S. 0 
    ISSN: 1539-6924
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: The paper by Metz challenges the view that stigma associated with a nuclear waste repository might lead to significant economic losses to the host region. We have been invited to comment on the general issues raised by this paper. We find that much of the evidence presented in the paper consists of factual and conceptual errors and misrepresentations of the research literature. Based on our review of evidence documenting the social and economic impacts of perceived risk, we conclude that stigma is an important phenomenon that is symptomatic of fundamental problems with the way in which nuclear waste facilities are sited.
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    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Many risk communications are intended to help the lay public make complex decisions about risk. To guide risk communicators with this objective, a mental models approach to the design and characterization of risk communications is proposed. Building on text comprehension and mental models research, this approach offers an integrated set of methods to help the risk communication designer choose and analyze risk communication content, structure, and organization. An applied example shows that two radon brochures designed with this approach present roughly the same expert facts as a radon brochure widely distributed by the U.S. EPA but meet higher standards on other content, structure, and organization criteria.
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