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  • 1
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    [s.l.] : Nature Publishing Group
    Nature 372 (1994), S. 10-10 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SIR - A recent leading article in Nature (371, 90; 1994) comments on drug testing of athletes. It points out that positive results from tests on well-known athletes are invariably made public, and asks why negative results are not also made public so that the prevalence of drug-taking by athletes ...
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  • 2
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    Nature 372 (1994), S. 13-14 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] IF the following pages are an attempt to describe the present state of science, they may nevertheless define the areas of our present ignorance, much in the way that a mould in a foundry will define the shape of the object to be cast in it - by exclu-sion, as it were. But what follows immedi-ately ...
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  • 3
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    Nature 372 (1994), S. 19-19 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] ARISTOTLE shared with Plato the view that different kinds of matter are composed of earth, air, fire and water in appropriate proportions. Understandably, the ancients concentrated on the qualities of matter. A brief chronology of succeeding events will clarify where we are now. o In the four ...
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  • 4
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    Nature 372 (1994), S. 20-20 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] THE outcome of the formative period of particle physics is familiar. Matter is made of quarks and leptons. Hadrons. Combinations of quarks make hadrons, which are either baryons (which, like electrons, have half-integer spin) or mesons (whose spin is either zero or inte-gral). There are six quarks, ...
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  • 5
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    Nature 372 (1994), S. 20-21 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] THE great neutrino puzzle has dragged on for a quarter of a century, and is not yet in sight of resolution. The presenting symp-tom is the deficit of neutrinos emitted by the Sun, first measured by R. Davies Jr by means of an experiment first planned 30 years ago1 and designed to provide direct ...
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  • 6
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    Nature 372 (1994), S. 23-23 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] THE Higgs boson, not yet discovered, is arguably the most important of all parti-cles in contemporary particle physics. To the extent that it is an indispensable part of the electroweak theory of the electro-magnetic and the weak nuclear forces, the theory will not be properly tested until the ...
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  • 7
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    Nature 372 (1994), S. 25-26 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] IT is puzzling now to be reminded that the Lowell Observatory at Flagstaff in Arizona was founded exactly a century ago because of the enthusiasm of Perc-ival Lowell for the study of Mars and of its presumed inhabitants. But that is simply a measure of the degree to which observation of the Solar ...
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  • 8
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    Nature 372 (1994), S. 704-708 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The structure of ARF1 has been determined to a resolution of 2.0 A by X-ray diffraction using multiple isomorphous replacement (Table 1). The folding motif of ARF 1 is that of an a//3 protein composed of a mixed ft -sheet core surrounded by a-helices (Fig. 1). This core is reminiscent of Ras p21 ...
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  • 9
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    Nature 372 (1994), S. 709-709 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Nature 372, 540-543 (1994). THE numbers on the depth scale in Fig. 3a and b in this Letter were incorrect, making the total width of the aftershock zone look as though it was 25 km, rather than 50 km as correctly reported in the text. The numbers on the j-axis of Fig. 3a should read 555, 575 and ...
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  • 10
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    Nature 372 (1994), S. 709-709 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] Nature 366, 324-327(1993) IN this Letter important references to earlier works were inadvertently left out. De Santis et aL, in the context of a theoretical conformational analysis of linear regular L,D polypeptides, suggested formation of parallel and antiparallel cylindrical structures through ...
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  • 11
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] TABLE 1 Polypeptide chain release activity of purified X. laevis Cll (expressed in E. coll) and human TB3-1 (expressed in yeast) proteins f[35S]Met Tetranucleotide Antibodies released Protein added added (pmol) His-tagged Cll UAAA - 0.38 UGAA - 0.39 UAGA - 0.35 poly (A, G, ...
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  • 12
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    Nature 372 (1994), S. 709-709 
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    Notes: [Auszug] Nature 363, 644-648 (1993) THE following correction concerns only the contribution to this paper of E.M., R.G. and E. Schafer. We purified a protein of MT 60,000 (60K) from oat seedlings that possesses an oligomeric structure of 600K and is partially similar to the cytosolic TCP1 proteins from ...
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  • 13
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    Nature 372 (1994), S. 710-710 
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    Notes: [Auszug] Nature 372, 467-470 (1994) DURING production a stray line was introduced across panel c of Fig. 4 of this Letter. The figure is reproduced ...
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  • 14
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    Nature 372 (1994), S. 39-40 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] EVER since 1982, when RNA was first found to catalyse the specific cleavage and formation of chemical bonds, we have wanted a detailed picture of such an RNA - a ribozyme. Protein crystallographers have provided numerous examples of en-zyme active sites built from amino acids. But we have had no ...
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  • 15
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    Nature 372 (1994), S. 44-45 
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    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] MOST T lymphocytes are born in the thymus. On page 100 of this issue1 Surh and Sprent show that most new-born T-lineage cells also die there. They there-by settle a long-standing controversy. The young thymus regenerates about one-third of its lymphoid content each day, a rate far in excess of the ...
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  • 16
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    Nature 372 (1994), S. 51-52 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] BETWEEN 1934 and 1961, A. J. Toynbee published a 12-volume review of the rise and fall of civilizations entitled! Study of History. Professor Cohen's lesser, but still massive, book might have been entitled A Study of the History of Science, for it ranges over the rise and fall of the sciences from ...
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  • 17
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    Nature 372 (1994), S. 486-486 
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    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] As motherhood used to be regarded as a universal virtue, so now is the public understanding of science. The research community is one of the principal supporters of the cause, and for good reason. There are two potential benefits to be won: a more sympathetic and general ...
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  • 18
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    Nature 372 (1994), S. 50-50 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] MAEMURA ET AL. REPLY - Hoffman et al. suggest that elevated blood pressure in ET-l+/ heterozygous mice1 may be caused by the impairment of sodium and water handling. To test this hypothesis, we fed 8-12-week-old male heterozygous and wild-type mice with a normal chow con- associated with ...
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  • 19
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    Nature 372 (1994), S. 85-88 
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    Notes: [Auszug] The experiments were carried out (Fig. 1) at the University of Bristol and the California Institute of Technology using shock-tube techniques first proposed in this context by Bennett3 and more recently developed in studies of volcanic jets4, explosive vaporization5 and high-speed dense dusty ...
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  • 20
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    Nature 372 (1994), S. 90-92 
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    Notes: [Auszug] Ten subjects with normal hearing (mean age, 26 years; 5 males) were presented with 1,000-Hz "standard' tones randomly interspersed with 'deviant' tones differing in frequency. Novelty, here defined as the magnitude of frequency deviance (the term traditionally used to refer to the property of a ...
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  • 21
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    Nature 372 (1994), S. 100-103 
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    Notes: [Auszug] FIG. 1 In situ detection of apoptotic cells in cryostat sections of thymus with a modified TUNEL method (x45). a, Top, normal C57BL/6 (B6) lymph nodes: stain-ing is prominent in germinal centres (gc) but is sparce in the paracortex (pc) and the mantle zones surrounding germinal centres. Bottom, B6 ...
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  • 22
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    Notes: [Auszug] Conformationally restricted synthetic retinoids that selectively enhance transcriptional activation by retinoic acid receptor (RAR) subtypes17 l9 or retinoid X receptor (RXR) homodimers20 are assumed to recognize differences in the ligand-binding pockets of these receptors, whereas the flexible ...
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  • 23
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    Nature 371 (1994), S. 725-725 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] LAST week's agreement on nuclear weapons between the United States and North Korea is not the happiest agreement of its kind. The US administration's political opponents are muttering about the deal. The International Atomic Energy Agency (IAEA) in Vienna is uneasy at the prospect of the delay ...
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  • 24
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    Nature 371 (1994), S. 727-727 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] Boston. As November's mid-term elections draw close, the US Congress and its activities have become subject to an unprecedented barrage of public criticism. But the beleagured institution has found itself a friend at Boston University. In choosing sites for major new ...
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  • 25
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    Notes: [Auszug] The RNA sequence chosen for the structure determination of the hammerhead ribozyme has a GAAA tetraloop connecting the base-paired strands of stem II (see accompanying manuscript6). The crystals in which the structure was solved has three copies of the hammerhead in the crystallographic asym-metric ...
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  • 26
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    Nature 371 (1994), S. 728-728 
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    Notes: [Auszug] London. European countries that restrict the access of researchers from Japan and the United States to nuclear physics facilities built with European funds risk retaliation against their own scientists, according to the report of a group of advisers to the Organization for Economic Cooperation and ...
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  • 27
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    Nature 371 (1994), S. 729-729 
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    Notes: [Auszug] Munich. A scientifically important fossil stolen more than two years ago from the Museum of the Palaeontological Institute in Moscow has been returned, thanks to the efforts of a German museum curator who identified it and fought for its return. But around 50 others are still missing. And, ...
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  • 28
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    Nature 371 (1994), S. 730-730 
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    Notes: [Auszug] Paris. The prospect of an independent European military satellite observation system moved a step nearer last week with reports that Germany is poised to back military space endeavours for the first time with a programme whose cost is estimated at between DM2 billion and ...
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  • 29
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    Nature 371 (1994), S. 731-731 
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    Notes: [Auszug] Washington. Tom Caskey, the geneticist who has played a leading role in recent moves to establish a map of the human genome available for 'unencumbered9 use by researchers in both the private and the public sectors, is to join the US pharmaceutical company Merck as senior vice president for basic ...
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  • 30
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    Nature 371 (1994), S. 734-734 
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    Notes: [Auszug] SIR - The European Science Foundation (ESF), based in Strasbourg, is a nongovernmental collaboration between the major national research funding organiza-tins in Europe. ESF has 55 member organizations from 20 European countries, a staff of 29 and an overall budget for 1994 of ...
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    Nature 371 (1994), S. 734-734 
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    Notes: [Auszug] SIR - The export of British universities to faraway lands is not a new phenomenon- many former British colonies have well-established universities that began as offshoots of British universities. Most have survived and adapted, with a gradual replacement of expatriate staff by well-qualified local ...
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  • 32
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    Nature 371 (1994), S. 735-738 
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    Notes: [Auszug] THE US public, usually indifferent to matters scientific, has suddenly become obsessed with DNA. Nightly newscasts routinely refer to the polymerase chain reaction (PCR) and even the tabloids offer commentary on restriction fragment length polymorphisms (RFLPs). The new-found ...
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  • 33
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    Nature 371 (1994), S. 741-742 
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    Notes: [Auszug] Judge not the play before the play is done. (Francis Quarles) TECHNOLOGY has caught up with Edwin Bubble's question of the 1920s: what are the scale and age of the Universe? Preliminary answers given last month by Pierce et al.1, and strongly backed up on page 757 of this issue by ...
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    Nature 371 (1994), S. 751-751 
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    Notes: [Auszug] ROBERTS REPLIES - Bowen and Sykes state that the pre-Anglian age proposed for the Boxgrove tibia is not underpinned by any geochronological age estimate determined by physical-chemical means. We applied various methods of age estimation to the sediments and the fossils contained therein at ...
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    Nature 371 (1994), S. 755-755 
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    Notes: [Auszug] CONNIE Barlow has followed her successful anthology From Gaia to Selfish Genes with another handsomely designed volume of writings by distinguished evolutionists, ranging from Charles Darwin through Julian Huxley to E. O. Wilson. In this compendium she traces their attempts to ...
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  • 36
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    Notes: [Auszug] The cloning is described of two related human complementary DNAs encoding polypeptides that interact specifically with the translation initiation factor elF-4E, which binds to the messenger RNA 5'-cap structure. Interaction of these proteins with elF-4E inhibits ...
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    Nature 372 (1994), S. 500-501 
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    Notes: [Auszug] OF the many similarities and parallels between vertebrates and Drosophila revealed in recent years, the relationship between T-cell activation and dorso-ventral patterning of the fly embryo must count as one of the more curious examples. Establishment of dorsoventral polarity is a ...
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    Nature 372 (1994), S. 499-500 
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    Notes: [Auszug] IT is always entertaining when a new insight turns our notions of good news and bad news on their head. Such is the case with Jeffrey S. Kargel's analysis, in the Journal of Geophysical Research1, of the economic potential of asteroids in Earth-crossing orbits. With the exception of ...
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    Nature 371 (1994), S. 756-756 
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    Notes: [Auszug] BETWEEN the orbits of Mars and Jupiter lie uncountable numbers of minor planets, or asteroids - to give them their more prosaic modern title. Asteroid number one, Ceres, was discovered on New Year's Day 1801. A thousand asteroids were known by 1921 and the number reached 2,000 by ...
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    Nature 372 (1994), S. 503-504 
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    Notes: [Auszug] INFANTICIDE has probably been practised by many different cultures throughout human history1. Where it has occurred, it is likely to have been biased against females. In recent years, sex preselection, prenatal sex determination and sex-selective abortion have facilitated the process ...
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    Nature 372 (1994), S. 506-506 
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    Notes: [Auszug] MEDICAL science is constantly announcing new perils in modern life, and new ways of dodging them. The result is an epidemic of little popular remedies: trace elements, vitamins, plant extracts and so on, all offering salvation from some dire medical fate. In a brilliant marketing ploy, Daedalus ...
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  • 42
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    Notes: [Auszug] In late embryos, the Krox-20/lacZ chimaeric gene is expressed in a complex pattern revealing a number of potential sites of Krox-20 expression (P.T. et al., manuscript in preparation), including part of the peripheral nervous system (PNS). Between 10 and 15 days after birth, ...
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    Nature 371 (1994), S. 812-812 
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    Notes: [Auszug] Nature 371, 151-154 (1994) EDITING of the opening sentence of the first paragraph of this Letter introduced a misleading error: the internal subdivisions given in parentheses should correctly read: "('b\obs\ 'interblobs' and layer 4B in VI; 'thin', 'thick' and 'interstripes' in ...
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    Nature 371 (1994), S. 637-638 
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    Notes: [Auszug] THE outcome of last Sunday's referendum in Finland on membership of the European Union (EU) will improve the chances that there will be 16 members next year. The vote (which has to be confirmed by a two-thirds majority of the Helsinki parliament) follows a similar result in Austria last June, but ...
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    Nature 371 (1994), S. 637-637 
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    Notes: [Auszug] THE old chestnut of the social connotations of the hereditary components of intelligence (as measured by Intelligence Quotient, or IQ), has resurfaced again in the United States. The occasion is the impending publication of a book, The Bell Curve: Intelligence and Class Structure in ...
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    Nature 372 (1994), S. 508-509 
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    Notes: [Auszug] SCHLESINGER AND RAMANKUTTY REPLY - We have used our physical climate/ocean model and four statistical autoregressive models to simulate the response of the climate system to white-noise forcing, for both the globe and the North Atlantic6. Each of the five models is run 1,000 times ...
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    Nature 371 (1994), S. 641-641 
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    Notes: [Auszug] Boston. High-temperature superconduc-tors move closer to real-world applica-tion to power transmission this week with the launch of a $6-miIlion project to build a prototype underground power line. The project is being mounted jointly by the Electric Power Research Institute (EPRI) - a power ...
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    Nature 372 (1994), S. 510-510 
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    Notes: [Auszug] SIR - Field experiments of hoarding birds of the genus Parus (titmice and chickadees) suggest that stored food is retrieved within a few days after storing1"3. The reason that stored food is retrieved shortly after storing could be to withdraw a temporary food surplus from ...
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    Nature 371 (1994), S. 644-644 
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    Notes: [Auszug] Seoul. South Korea's new Pohang Univer-sity of Science and Technology (POSTECH) has come top in the country's first attempt to rank its universities. POSTECH is supported by one of the world's most profitable steel companies, Pohang Iron and Steel Com-pany (POSCO). The ranking was ...
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    Nature 371 (1994), S. 808-812 
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    Notes: [Auszug] Rebinding of photodissociated CO to myoglobin proceeds by two distinct processes: the CO can either rebind from within an internal cavity called the distal haem pocket, or it can escape and rebind from the solvent. Lowering the temperature slows and separates the processes, until ...
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    Nature 371 (1994), S. 646-646 
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    Notes: [Auszug] SIR-In his recent article1 on the origin of the cell membrane, John Maddox focuses on the model of Ourisson and Nakatani. The features of this model have striking similarities to another theory, not mentioned by Maddox, namely that of Gunter Wachtershauser2. This latter theory ...
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    Notes: [Auszug] SIR - As a postscript to the silly season, and while jt is still in the news (Nature 370, 323; 1994), your readers may appreciate a mnemonic for 30 digits of ji. The number of letters in each word represents the value of the digit:- Que j'aime a faire apprendre un nombre util aux ...
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    Nature 371 (1994), S. 650-651 
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    Notes: [Auszug] WITH an average elevation of 5 kilometres and a surface area of over 5 million square kilometres, the Tibetan plateau is the largest topographic upland on Earth. Its association with the actively rising Himalayan mountains dramatically illustrates the forces associated with the ...
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    Nature 371 (1994), S. 653-653 
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    Notes: [Auszug] ANDRE Lwoff, who died on 30 September, was one of the fathers of molecular biology. He began his scientific life at the age of 19, and during the course of his career made a major contribution to the transformation of biology from a collec-tion of dispersed disciplines into a single, ...
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    Notes: [Auszug] Induction of testis development in mammals requires the presence of the Y-chromosome gene SPY. This gene must exert its effect by interacting with other genes in the sex-determination pathway. Cloning of a translocation chromosome breakpoint from a sex-reversed patient ...
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    Nature 372 (1994), S. 530-532 
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    Notes: [Auszug] With the Very Large Array (VLA) in the most compact D configuration, four fields centred around M82 were observed (3 h per field) on 24 and 25 January 1990, and eight additional fields including M81 and NGC3077 were observed (2 h per field) on 29 April and 1 May 1991, using all 27 ...
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    Nature 371 (1994), S. 661-661 
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    Notes: [Auszug] SIR - Solid-state high-pressure techniques are very useful for synthesizing polycrystalline copper oxide superconduc-tors, including the recently discovered HgBa2Can_1CuM02rt+2+s (Hg-12(n -1)«) and the infinite-layer compound Ca\-xAxCuO2 (where A is an alkaline earth ...
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    Nature 371 (1994), S. 664-664 
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    Notes: [Auszug] SIR - Guilderson et at.1 provided geo-chemical evidence that tropical sea sur-face temperatures (SSTs) in the western Atlantic may have been 5 ° C colder dur-ing the last ice age. This conclusion appears to reconcile a discrepancy be-tween tropical upland changes of 5-6 ...
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    Nature 371 (1994), S. 665-665 
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    Notes: [Auszug] IT cannot be in dispute that the transition from an illiterate to a literate culture entails a vast range of consequences over and above the ability to read this week's Nature. David Olson's fascinating (and infuriating) book advances a thesis that goes well beyond the (important) ...
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    Nature 371 (1994), S. 667-668 
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    Notes: [Auszug] A GEOPHYSICIST studies Earth's subsur-face by measuring bulk properties such as seismic velocity, electrical conductivity, thermal conductivity or magnetization from the surface or in a borehole. Then, using the tools of rock physics, he or she extracts from these measurements ...
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    Nature 371 (1994), S. 693-695 
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    Notes: [Auszug] FIG. 1 Main figure, composition profile produced by Ni-Mg diffusion, as determined by electron microprobe analysis, for a sample annealed at 1,200 °C and 13.7 GPa for 7.2 x io4 s. In all our experiments on spinel, the samples were compressed at room temperature to 5.0 GPa (above ...
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    Nature 371 (1994), S. 700-702 
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    Notes: [Auszug] When a driver fixates a mountain ridge in the distance, his direction of gaze is practically stationary, and the retina receives a motion pattern that radiates outward from his direction of heading. In contrast, when rotating his eye and his head so as to fixate a road sign, he will ...
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    Nature 371 (1994), S. 681-683 
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    Notes: [Auszug] In this study the starting material was synthesized using oxides previously prepared by direct oxidation of Y, Ba and Cu metals. Sinterings at 945 °C (15h) were repeated several times with intermediate grindings in a glove-box. Small amounts (〈2 wt%) of BaCuO2 + s as a second ...
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    Notes: [Auszug] In the human colonic epithelial cell line T84 (ref. 6), carbachol initally stimulates a transient elevation of [Ca2+]i and rise in Cl secretion which return to near-control levels within 10 min7'8. However, prolonged pretreatment with carbachol blocks subse-quent ...
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    Nature 371 (1994), S. 720-720 
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    Notes: [Auszug] Nature 370, 662-666 (1994) THE last line of the Acknowledgements section was omitted from this Letter. This read: "C. W. G. Boys was supported by the Wellcome ...
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    Notes: [Auszug] PLEASE follow these guidelines so that your manuscript may be handled expeditiously. Nature is an international journal covering all the sciences. Contributors should therefore bear in mind those readers who work in other fields and those for whom English is a second language, and write clearly ...
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    Nature 371 (1994), S. 543-543 
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    Notes: [Auszug] THE search for criminals to be held responsible for the French contaminated-blood scandal continues (seepage 548). Among those now arraigned are M. Laurent Fabius, once President Frangois Mitterrand's prime minister, and M. Frangois Gros, the distinguished cell biologist and ...
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    Nature 371 (1994), S. 544-544 
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    Notes: [Auszug] EVERYBODY knows that nature is red in tooth and claw, but it can go too far. There will be consternation among readers of the London Times at the report (10 October) of recent happenings on the He Aux Aigrettes, off Mauritius. The island is one of the centres at which the Jersey Wildlife ...
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    Notes: [Auszug] To investigate the functions of TNF, we generated mice that do not express TNF-R2. A targeting vector containing a neo-mycin-resistance (neor) cassette inserted into the second exon of a 9-kilobase (kb) TNF-R2 genomic clone (Fig. la) was electro-porated into embryonic stem (ES) ...
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    Nature 372 (1994), S. 574-574 
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    Notes: [Auszug] Two months ago, on 7 October, a beautiful article by Mark Skolnick and 44 colleagues describing the long awaited discovery of the gene for hereditary breast and ovarian cancer, BRCA1, was published in Science1. That same day the complete nucleotide sequence of BRCA1 was unveiled in ...
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    Nature 371 (1994), S. 552-552 
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    Notes: [Auszug] SIR - In her diatribe against the role of primary care in Clinton's plans for health-care reform, Culliton demonstrates that C. Everett Koop does not have a monopo-ly on patent and dangerous nonsense. She misses the main point about general prac-tice: namely that well-trained ...
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    Nature 371 (1994), S. 550-550 
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    Notes: [Auszug] Paris. France is considering taking steps to simplify the regulatory procedures for gene therapy and to encourage the wider use of the technique in its public hospitals, according to Philippe Douste-Blazy, the country's junior health minister. Gene-therapy trials were first ap-proved ...
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    Notes: [Auszug] SIR - In an article "Primary care is not the answer" (Nature 370, 501; 1994), Barbara J. Culliton draws attention to some "less visible provisions" in President Bill Clinton's health-care plan, such as forcing 50 per cent of physicians into general practice. She believes that this ...
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    Nature 371 (1994), S. 553-554 
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    Notes: [Auszug] THE practice of screening tropical natural products for novel pharmaceuticals has been much in the news lately. With the adoption worldwide of the UN Conven-tion on Biological Diversity, the interests of the pharmaceutical and biotechnology industries seem to have been pitted against those of ...
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    Notes: [Auszug] Rapamycin prevents the activation of the late-Gl cyclin E/ Cdk2 kinase in the T-cell clones D10.G4.1 (Fig. 10) and CTLL-2 (ref. 8) and primary T lymphocytes (data not shown). The inactivity of cyclin E/Cdk2 in rapamycin-treated cells is not due to an inhibition of the expression of ...
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    Nature 372 (1994), S. 575-578 
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    Notes: [Auszug] PIERCE's mouse and human IsoCell CDS isolation kits are affinity chromatography tools for CDS cell enrichment (Reader Service No. 100). The company says that virtually all B lymphocytes and CD4 cells are removed using a negative selection process on affinity columns. And, a large ...
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    Nature 372 (1994), S. 389-390 
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    Notes: [Auszug] THE European Commission, the executive arm of the Euro-pean Union (EU), used to be a mere bit player in research. When its direct spending amounted to less than 2 per cent of spending in its member states, the frequent waywardness of its decisions on research could be overlooked. But ...
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    Notes: [Auszug] THE British evidently have some way to go before they become sensitized to the improper use of the scientific literature. So much is clear from the circumstances surround-ing the publication last August of a paper in the British Journal of Obstetrics and Gynaecology (101, 716-717; 1994) by J. M. ...
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    Nature 372 (1994), S. 391-391 
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    Notes: [Auszug] Washington. A long-awaited report released in Washington this week finds Theresa Imanishi-Kari, co-author with the Nobel laureate David Baltimore of an controver-sial immunology paper, to be guilty of 19 charges of scientific misconduct. It recom-mends that she be barred from receiving federal ...
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    Nature 371 (1994), S. 567-568 
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    Notes: [Auszug] CONTROVERSY has long surrounded the use by the United States of fission atomic bombs against Japan and the subsequent US development of the much more potent fusion weapon, the hydrogen bomb. As these epochal events recede into the past, revisionist historians who were not there at ...
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    Nature 372 (1994), S. 392-392 
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    Notes: [Auszug] San Francisco. Researchers at California's two largest government-funded research laboratories fear that they may face major budget cuts - or possibly even elimination - under the Republican-dominated Con-gress elected last month. A major part of the platform on which the Republicans won ...
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    Notes: [Auszug] Since its launch aboard the Russian GRANAT spacecraft on 1 December 1989, the French telescope Sigma7 has observed twice per year the Galactic Centre region in the 35-1,300 keV band. The Sigma imaging performances are obtained by the combination of a position-sensitive /-ray camera, ...
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    Notes: [Auszug] Cerebral activation was monitored in normal humans (six right-handed male subjects, 22-41 years old) using a positron emission tomograph. The subjects had given their informed con-sent. Changes in regional cerebral blood flow (rCBF) were measured using the intravenous radioactively ...
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    Nature 371 (1994), S. 606-609 
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    Notes: [Auszug] FIG. 1 Targeted disruption of the Ipfl gene, a, Schematic representation of targeting construct, genomic DNA and the expected product of homologous recombination. The two exons of Ipfl are indicated by cylinders and the bac-terial neomycin gene, under control of the herpes simplex ...
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    Nature 372 (1994), S. 394-394 
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    Notes: [Auszug] Tokyo. Hiroyuki Yoshikawa, the president of Tokyo University, has won the approval of the university's senate to set up a special 'presidential fund' based on a one percent levy on donations that faculty members receive each year from private industry. The fund will amount to only ¥60 ...
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    Notes: [Auszug] Strasbourg. The European Science Founda-tion (ESF), Europe's 'bottom-up' research organization whose members are national research funding agencies, is still seeking a new role, although its annual assembly in Strasbourg last week failed, despite its ef-forts, to achieve significant ...
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    Notes: [Auszug] Strasbourg. Antonio Ruberti, the European Union's research commissioner who will return to Italy as a professor of systems analysis at the Uni-versity of La Verna at the end of the year, is doing every-thing he can to leave a clear desk for Mme Edith Cresson, the former French prime ...
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    Notes: [Auszug] Paris. A local court in northern Germany last week blocked the transport of the first consignment of nuclear waste to the contro-versial interim storage repository at Gorleben from the Phillipsburg power station in Baden-Wurttemberg. The decision buys time for Germany's anti-nuclear movement, which ...
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    Nature 372 (1994), S. 396-396 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Montreal. Quebec's Superior Court has been asked to suspend an inquiry ordered by McGill University into the death of the neuropsychologist Justine Sergent, who committed suicide last April (see Nature 369, 176; 1993). It has also been asked to remove the lawyer that the university ap-pointed to ...
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    [s.l.] : Nature Publishing Group
    Nature 371 (1994), S. 470-470 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SIR - Is it really true, as you say, that "the message about the dangers of AIDS is not getting through"1? Numerous studies, even among disadvantaged groups2'3, show that knowledge about transmission routes is very high, but there is a hard core of people familiar to clinicians (perhaps 35 per cent ...
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    [s.l.] : Nature Publishing Group
    Nature 371 (1994), S. 482-482 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SIR - Falk et al.1 in their interesting Scientific Correspondence demonstrated the high risk of death due to burial by avalanches, and the importance of avoiding them. I cannot fully agree, however, with their conclusion that the depth of burial has no direct influence on survival chances. I ...
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    [s.l.] : Nature Publishing Group
    Nature 372 (1994), S. 397-397 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Paris. France's ministries of health and of research have announced their intention to coordinate their support for genome research and its clinical applications under the um-brella of a single so-called ' Genome-Sante' programme. The initial goals of the joint programme, which will ...
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    [s.l.] : Nature Publishing Group
    Nature 371 (1994), S. 481-482 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SIR - Hocking1 has not compared like with like, as far as I can see. He compared the costs of production of reusable and disposable cups, but although he then added to the reusables the cost of reuse, he did not add to the disposables the cost of disposal. If without disposal costs a ceramic ...
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    [s.l.] : Nature Publishing Group
    Nature 371 (1994), S. 485-486 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] THE first quarter of the twentieth century saw a comprehensive transformation of physical ideas. The elaborate structure built on Newton's dynamics and Maxwell's electromagnetism had already begun to show flaws when, within a few years, the discovery of X-rays, the electron and the quantum ...
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    [s.l.] : Nature Publishing Group
    Nature 372 (1994), S. 398-399 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SIR - It is welcome news that the FBI, in an astonishing 180° change of direction, has agreed to adopt the interim ceiling principle recommended by the National Research Council (NRC)1. The reversal of policy is long overdue in view of the acceptance of the approach by many other ...
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    [s.l.] : Nature Publishing Group
    Nature 372 (1994), S. 399-399 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SIR - Colin Macilwain1 recorded the following memorable remark of a US politician: "we pay agencies to fight fires, not light them". In Western Australia, forest managers2 have for three decades been using prescribed fires to minimize the possibility of destructive forest fires ...
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    [s.l.] : Nature Publishing Group
    Nature 372 (1994), S. 399-399 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SIR - I wish to clarify your report (Nature 370, 85; 1994) about the open letter by ten Russian scientists, of whom I was one. Your report says that those responsible for building the atomic bomb in the Soviet Union were motivated by the fear that, if they failed, they would be dismissed as ...
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    [s.l.] : Nature Publishing Group
    Nature 372 (1994), S. 399-399 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SIR - Your leading article "How to deal with dreadfulness" (Nature 370, 313-314; 1994) suggests that what concerns you is what appears "dreadful" to those who follow the news media, rather than the experience of those of us who live every day with the events that interest the reporters. You ...
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    [s.l.] : Nature Publishing Group
    Nature 371 (1994), S. 534-537 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] To compare the effect of p21 on DNA repair and replication, whole-cell extracts were prepared from RKO cells, a human colorectal carcinoma cell line containing wild-type p53 (ref. 10). Following published procedures9, we showed that the RKO cell extract preferentially repaired ultraviolet-damaged ...
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    [s.l.] : Nature Publishing Group
    Nature 371 (1994), S. 539-542 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SIEVERS Instruments has developed a system to determine nitrate and nitrite concentration in biological fluids such as serum, cell cultures and tissue perfusate using the Model 270B nitric oxide analyser (Reader Service No. 100). Based on reduction with vanadium chloride in hydrochloric acid, the ...
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