ISSN:
1573-4919
Keywords:
interferon
;
oligoadenylate synthetase
;
phenylhydrazine-induced anemia
;
reticulocyte maturation
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
Notes:
Summary The (2′–5′) oligoadenylate synthetase normally found in interferon-treated cells has also been detected in considerable amounts in normal rabbit reticulocytes not exposed to interferon. The activity of this enzyme has been followed during the development of the reticulocytes to erythrocytes. A high level was found just after the formation of reticulocytes and this activity decayed with a half-life of about 3 days. In lymphocytes the (2′–5′) oligoadenylate synthetase was found to stay at a constant level, which indicates the absence of interferon in the plasma.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00230077
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