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  • Articles  (18,448)
  • Springer  (16,677)
  • Nature Publishing Company  (1,771)
  • National Academy of Sciences
  • 1995-1999  (10,494)
  • 1975-1979  (7,954)
  • Process Engineering, Biotechnology, Nutrition Technology  (18,448)
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  • Articles  (18,448)
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  • 1
    Electronic Resource
    Electronic Resource
    A second Human Genome Project? (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 793-793 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] With only 4% of the Human Genome Project completed, albeit ahead of schedule, one might conclude that the so–called genomics revolution has quite a bit more time on the meter. But there is another aspect of the human genome that we can no longer afford to ignore: The more than three million ...
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    URL: http://dx.doi.org/10.1038/nbt0998-793a
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  • 2
    Electronic Resource
    Electronic Resource
    Latin America: CYTED-BT: An international biotechnology network that works (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 794-794 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Too often, international programs for cooperation in biotechnology, particularly those involving “developing” countries, begin with the best intentions, but over time, sadly, produce very little in the form of tangible accomplishment. Thus, it is both refreshing and encouraging to find ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt0998-794
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  • 3
    Electronic Resource
    Electronic Resource
    No prokaryotic GPI anchoring (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 799-799 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] To the editor: In a recent article1 in Nature Biotechnology, Jung et al. describe the construction of a chimerical protein made of Zymomonas mobilis levansucrase and Pseudomonas syringae ice nucleation protein (Inp). The fusion protein is expressed in Escherichia coli and displays cell surface ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt0998-799a
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  • 4
    Electronic Resource
    Electronic Resource
    No prokaryotic GPI anchoring (reply) (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 799-799 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Jung et al. reply: Kozloff et al. identified phosphatidylinositol, which is a relatively rare component of the prokaryotic cell wall, as a major component of the ice-nucleating site on the outer surface off! syringae1. They also suggested that the Inp is structurally very similar to the GPI anchor ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt0998-799b
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  • 5
    Electronic Resource
    Electronic Resource
    Centaur abandons US for European IPO (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 807-807 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Centaur Pharmaceuticals (Sunnyvale, CA) is the first US biotechnology company to go public abroad; it began listing on the Swiss exchange SWX (Zurich, Switzerland) on August 27, hoping to raise at least CFR80 million ($54 million). The opportunity for biotechnology initial public offerings ...
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    URL: http://dx.doi.org/10.1038/nbt0998-807a
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  • 6
    Electronic Resource
    Electronic Resource
    Mystery plea for review of seed and biotech mergers (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 811-811 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Somebody with deep pockets and a will to remain anonymous appears keen to redirect the course of the US agricultural biotechnology business sector. Arguing that recent and future consolidations could undermine innovation in this sector and eventually weaken US agricultural competitiveness, a ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt0998-811
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  • 7
    Electronic Resource
    Electronic Resource
    A genome-based approach for the identification of essential bacterial genes (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 851-856 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] We have used comparative genomics to identify 26 Escherichia coli open reading frames that are both of unknown function (hypothetical open reading frames or y-genes) and conserved in the compact genome of Mycoplasma genitalium. Not surprisingly, these genes are broadly conserved in the bacterial ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt0998-851
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  • 8
    Electronic Resource
    Electronic Resource
    A rational design strategy for protein hormone superagonists (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 871-875 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] By combining evolutionary considerations, sequence comparisons and homology modeling we have designed recombinant human thyroid-stimulating hormone (hTSH) analogs with increased receptor binding and activity. The introduction of seven basic residues into the peripheral loops of hTSH resulted in up ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt0998-871
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  • 9
    Electronic Resource
    Electronic Resource
    People (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 880-880 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Guilford Pharmaceuticals (Baltimore, MD) has announced the appointment of David H. Bergstrom as vice president, pharmaceutical and chemical development. Dr. Bergstrom joins Guilford from Hoechst Marion Roussel, where for the past two years he was director of pharmaceutical and analytical sciences. ...
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    URL: http://dx.doi.org/10.1038/nbt0998-880
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  • 10
    Electronic Resource
    Electronic Resource
    Jeremy Rifkin is biotechnology's biggest fan (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 695-695 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Extreme fans are fanatics. And if we ventured the opinion that Jeremy Rifkin was fanatical when it came to biotech, few would disagree. But Rifkin's fanaticism is not, at least yet, of the variety that borders on lunacy. Quite the contrary, his deep passion for biotechnology is reflected by ...
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    URL: http://dx.doi.org/10.1038/nbt0898-695b
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  • 11
    Electronic Resource
    Electronic Resource
    Cell penetrating PNA constructs regulate galanin receptor levels and modify pain transmission in vivo (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 857-861 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Peptide nucleic acids (PNAs) form stable and tight complexes with complementary DNA and/or RNA and would be promising antisense reagents if their cellular delivery could be improved. We show that a 21-mer PNA, complementary to the human galanin receptor type 1 mRNA, coupled to the cellular ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt0998-857
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  • 12
    Electronic Resource
    Electronic Resource
    Science-free GM food tests advance (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 712-713 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] A European Council regulation stipulating that any food product made from some maize and soya varieties containing “foreign” DNA or proteins must be labeled accordingly (Nature Biotechnology 16:605, 1998) comes into force in September. In effect, the regulation means that all soya and ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt0898-712b
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  • 13
    Electronic Resource
    Electronic Resource
    Patenting DNA sequences (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 877-877 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] It is essential that all patentable subject matter be recited in the claims of a patent in order to have the most advantageous marketing position since in many startup biotechnology ventures, the patent portfolio is one of the largest and sometimes only asset. The claims located at the end of every ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt0998-877
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  • 14
    Electronic Resource
    Electronic Resource
    FISH goes with the flow (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 723-724 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The integrity of chromosome structure is essential for the maintenance of life. In particular, telomeres—stretches of repetitive DNA at the end of each of the chromosome arms—have been implicated in processes such as cell aging and transformation. The lack of a routine method for ...
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    URL: http://dx.doi.org/10.1038/nbt0898-723
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  • 15
    Electronic Resource
    Electronic Resource
    The problem with thalidomide's new incarnation (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 695-695 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The US Food and Drug Administration's (FDA) approval of thalidomide for the treatment of Hansen's disease—once called leprosy— shows just how government and industry can work together to bring back to market a drug that, while infamous for the terrible birth defects it produced when ...
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    URL: http://dx.doi.org/10.1038/nbt0898-695a
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  • 16
    Electronic Resource
    Electronic Resource
    Errata (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 702-702 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] In “Viral sequences enable efficient and tis-sue-specific expression of transgenes in Xenopus” (Nature Biotechnology 16:253–257, March 1998), the plasmid p2L contains one ITR from the left end, and one ITR from the right end of wild-type AAV, rather than two copies of the right ...
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    URL: http://dx.doi.org/10.1038/nbt0898-702c
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  • 17
    Electronic Resource
    Electronic Resource
    Patent office resurrects EST debate (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 711-711 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The debate in the US over whether broad patent claims to expressed sequence tags (ESTs)—randomly isolated fragments of DNA used mainly as probes to isolate functional genes—are patentable lives on, despite a court ruling last September that could have laid the issue to rest. The concern ...
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    URL: http://dx.doi.org/10.1038/nbt0898-711
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  • 18
    Electronic Resource
    Electronic Resource
    Caveat browser warning on Internet IPOs (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 716-716 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Internet initial public offerings (IPOs) are the latest way for early-stage companies to raise capital without losing chunks of the company to venture capitalists or having to pay large underwriting fees associated with administering a traditional IPO. The first biotechnology company to have ...
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    URL: http://dx.doi.org/10.1038/nbt0898-716a
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  • 19
    Electronic Resource
    Electronic Resource
    Skipping a step with neural nets (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 722-723 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Theoretical studies of receptor–ligand interactions using the tihree-dimensional structure of the receptor (and possibly the ligand), and statistical mechanics or molecular dynamics methods to analyze them, suffer from two drawbacks. First, details of how macromolecules interact with each ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt0898-722
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  • 20
    Electronic Resource
    Electronic Resource
    Computer-assisted rational design of immunosuppressive compounds (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 748-752 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] We describe the rational design of immunosuppressive peptides without relying on information regarding their receptors or mechanisms of action. The design strategy uses a variety of topological and shape descriptors in combination with an analysis of molecular dynamics trajectories for the ...
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    URL: http://dx.doi.org/10.1038/nbt0898-748
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  • 21
    Electronic Resource
    Electronic Resource
    Cloning: Big business is high on the Honolulu method (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 797-797 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] When the news broke in late July that Ryuzo Yanagimachi and Teruhiko Wakayama at the University of Hawaii (Honolulu) had successfully cloned 50 mice from adult cells, it was evident to many that cloning is here to stay. Coming only 17 months after the historic cloning of Dolly the lamb in Scotland, ...
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    URL: http://dx.doi.org/10.1038/nbt0998-797
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  • 22
    Electronic Resource
    Electronic Resource
    Latin America: ONSA, the São Paulo Virtual Genomics Institute (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 795-796 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The state of São Paulo, in Southeastern Brazil, contains approximately one-tenth of the population of Latin America and historically has been a driving force for economic development in the region. The state agency responsible for funding scientific research, known as Fundação ...
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    URL: http://dx.doi.org/10.1038/nbt0998-795
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  • 23
    Electronic Resource
    Electronic Resource
    Cloning: On human cloning (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 798-798 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Since cloning is a human idea, and the only people (as far as is known) who are doing cloning are human people, it is interesting to me to speculate on the mind sets from which we might turn out to be working. I recall reading in a newspaper recently, among endless titillating speculations about ...
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    URL: http://dx.doi.org/10.1038/nbt0998-798
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  • 24
    Electronic Resource
    Electronic Resource
    This Month in Nature Biotechnology (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 806-806 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The fructan beet Although identical in appearance to its non-transformed counter-part, the addition of a gene encoding 1-sucrose:sucrose fructosyl transferase has effectively created a fructan beet whose primary carbohydrates are low molecular weight fructans as opposed to sucrose (see pp. 822 and ...
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    URL: http://dx.doi.org/10.1038/nbt0998-806
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  • 25
    Electronic Resource
    Electronic Resource
    Cloning improvements suggested (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 809-809 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The recent birth of three generations of cloned mice from an adult somatic cell by scientists at the University of Hawaii (Honolulu) suggests that cloning, or nuclear transfer and reprogramming of mammalian cells, is both possible and reproducible in species other than the sheep. Although the ...
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    URL: http://dx.doi.org/10.1038/nbt0998-809
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  • 26
    Electronic Resource
    Electronic Resource
    Xenophobia quelled in the UK (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 816-816 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The UK Department of Health (London) has begun to fill a long-standing regulatory gap by announcing measures that will permit the consideration of xenotransplant clinical protocols. A public consultation on preliminary guidelines established that ‘xenotransplant regulation should have ...
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    URL: http://dx.doi.org/10.1038/nbt0998-816a
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  • 27
    Electronic Resource
    Electronic Resource
    Peptide nucleic acid smugglers (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 819-820 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Sneaking an oligonucleotide across the cell membrane is no easy task. Indeed, peptide nucleic acids (PNAs)—oligonucleotides in which the sugar-phosphate backbone has been replaced with a neutral peptide backbone—are particularly difficult to smuggle into cells, a factor that has limited ...
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    URL: http://dx.doi.org/10.1038/nbt0998-819
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  • 28
    Electronic Resource
    Electronic Resource
    Laboratory firepower for infectious disease research (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 825-829 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Batch science machines could one day perform the work of hundreds of humans, enhancing public health surveillance, increasing experimental reproducibility, and liberating researchers from the bench so that they can focus on “big” conceptual problems. Infectious diseases pose ...
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    URL: http://dx.doi.org/10.1038/nbt0998-825
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  • 29
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    Electronic Resource
    From bits to bases: Computing with DNA (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 830-832 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Biocomputers could one day rival the efficiency of silicon computers for solving complex mathematical problems. The time is 2010. A busy executive at a shipping company must quickly calculate the optimum delivery routes and schedules for all his vehicles. He flicks a switch on a machine at his ...
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  • 30
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    Large-scale production of UDP-galactose and globotriose by coupling metabolically engineered bacteria (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 847-850 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] A large-scale production system of uridine 5′-diphospho-galactose (UDP-Gal) has been established by the combination of recombinant Escherichia coli and Corynebacterium ammoniagenes. Recombinant E. coli that overexpress the UDP-Gal biosynthetic genes galT, galK, and galU were generated. C. ...
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    URL: http://dx.doi.org/10.1038/nbt0998-847
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  • 31
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    New Products (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 881-881 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Liquid handling Pipette controller Rainin's (Emeryville, CA) GlassMaster pipette controller is lightweight and easy to use with all pipettes from 1 to 100 ml; its unique mode selection switch allows the user to select between three aspirate and dispense speeds: low, full, and gravity. GlassMaster ...
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  • 32
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    Protein Folding: An unacknowledged problem for structural genomics? (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 696-696 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] It took more than 50 years, but it happened. Molecular biologists—perhaps not so quick after all—finally realized what J.D. Bernal knew all along: that protein structure was the key to biology, and the advent of structural genomics must be celebrated as the real beginning of making ...
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  • 33
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    Telomerase and cellular lifespan: Ending the debate? (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 701-702 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] A recent commentary by Harry Rubin1 examined the role of telomere loss in cell aging and critically analyzed the demonstration that forced expression of telomerase can extend cell lifespan in vitro2. This was discussed with reference to human aging and cell senescence. We believe his conclusions ...
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    URL: http://dx.doi.org/10.1038/nbt0898-701
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  • 34
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    Business and Regulatory News (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 703-705 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Clones from adult cow Researchers from Kinki University (Osaka, Japan) andIshikawa Prefectural Livestock Research Centre (Ishikawa Prefecture, Japan) last month announced the birth of twin calves cloned from somatic cells taken from an adult cow. According to scientists from the two research ...
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    NIH panel urges technology transfer reforms (1998)
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    Nature biotechnology 16 (1998), S. 710-710 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] Current negotiations over intellectual property rights are “burdensome,” and “current trends pose a serious threat” to biomedical research and development, says a Working Group on Research Tools. The panel of seven outside experts was appointed by the NIH (Bethesda, MD) to ...
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    Biotech and pharma face more costly clinical trials (1998)
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    Nature biotechnology 16 (1998), S. 714-714 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Biotechnology and pharmaceutical companies could face longer and more costly clinical trials should recommendations in a new report issued in June by the US Department of Health and Human Services (HHS; Washington, DC) Office of the Inspector General be implemented. The report, “A Time for ...
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    Europeans hothouse genomics (1998)
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    Nature biotechnology 16 (1998), S. 716-717 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The research ministries of both Germany and France are attempting to stimulate plant genomics in their respective countries by establishing networks of related projects involving academic and industrial researchers on the one hand, and model and crop plants on the other. In the near future, the two ...
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    Shrinking DNA diagnostics to fill the markets of the future (1998)
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    Nature biotechnology 16 (1998), S. 725-727 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] At the beginning of August, the German/US gene chip company Sequenom (Hamburg, Germany, and San Diego, CA) will unveil what it believes to be the world's first fully integrated DNA-chip–based diagnostic system. It will not be a small device. It would not sit comfortably alongside the ...
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    Telomere length dynamics in human lymphocyte subpopulations measured by flow cytometry (1998)
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    Nature biotechnology 16 (1998), S. 743-747 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] To measure the average length of telomere repeats at chromosome ends in individual cells we developed a flow cytometry method using fluorescence in situ hybridization (flow FISH) with labeled peptide nucleic acid (PNA) probes. Results of flow FISH measurements correlated with results of ...
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    Epstein-Barr–based episomal chromosomes shuttle 100 kb of self-replicating circular human DNA in mouse cells (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 762-768 
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    Notes: [Auszug] We describe the microcell fusion transfer of 100–200 kb self-replicating circular human minichromosomes from human into mouse cells. This experimental approach is illustrated through the shuttling of the latent 170 kb double-stranded DNA genome from the human herpesvirus, Epstein-Barr virus, ...
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    The reimportation loophole (1998)
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    Nature biotechnology 16 (1998), S. 783-783 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] How would you react if one of your company's products was exported at a sharp discount to a foreign sales distributor and then began reappearing in your domestic market—at cut-rate prices? For biotechnology companies, this kind of nightmare may become a reality because of a recent US Supreme ...
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    Buying antibodies on the Internet (1998)
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    Nature biotechnology 16 (1998), S. 788-788 
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    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Just how widespread antibodies are on the Internet can be seen from a simple search: A visit to the Alta Vista search engine recently turned up nearly 150,000 documents—everything from researchers' home and laboratory pages to hundreds of manufacturers, suppliers, and distributors of ...
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    Pharmacogenomics and diagnostics (1998)
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    Nature biotechnology 16 (1998), S. 791-792 
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    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The field of pharmacogenomics addresses the issues of gene sequence variation and its effects on drug-response variability as a platform for the discovery of novel, highly effective therapies1. The enticing value for both drug developers and consumers is that this will help reduce the cost of drug ...
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    People (1998)
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    Nature biotechnology 16 (1998), S. 789-789 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] Richard T. Daly has been named to the board of directors of Visible Genetics (Toronto, Ontario, Canada). He is founder, chairman, and CEO of Clinical Partners, Inc., which provides therapy-specific management of HIV and AIDS patients for employers and managed healthcare organizations in California ...
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    New Products (1998)
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    Nature biotechnology 16 (1998), S. 790-790 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Peptides & enzymes Pig preservative Pentapharm (Basel, Switzerland) has developed an alternative to serum albumin for the stabilization of proteins. Prionex, a polypep-tide fraction of porcine dermal collagen, maintains the biological activity of purified proteins during handling and ...
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    Structural genomics: Simply the next new thing— or is this it? (1998)
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    Nature biotechnology 16 (1998), S. 595-595 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] From its heady beginnings almost 20 years ago until now, biotechnology, like other marriages of science, technology and commerce, has thrived on the idea of the “next new thing.” But unlike analogous combinations—the desktop computer industry, for example—the biotechnologies ...
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    Think royalties, not caps (1998)
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    Nature biotechnology 16 (1998), S. 595-595 
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    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Earlier this year, US Representative Bernard Sanders of Vermont introduced the Health Care Research and Development and Taxpayer Act, which resurrected and expanded the notion of putting price caps on drugs resulting from research initiated by federally funded institutions and universities. The ...
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    Biopharmaceutical Research: Integrating information technology and drug discovery processes (1998)
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    Nature biotechnology 16 (1998), S. 597-598 
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    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Not long ago, a society that relied on computer technology and centered on lightening-fast information retrieval and exchange seemed a remote prospect. The cryptic language and cumbersome interface of computers made them largely unfathomable to all but a few select specialists. It took the ...
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    Regional Development: Finding the substance behind the smoke: Who is using biotechnology? (1998)
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    Nature biotechnology 16 (1998), S. 596-597 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Biotechnology is widely seen as a pervasive new suite of technologies with current or potential applications in a large number of industries, including pharmaceuticals, chemicals, mining, forestry, fisheries, agriculture, and food processing. There is, however, a lack of information on the actual ...
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    Technology Transfer: Changing university roles in the century of biotechnology (1998)
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    Nature biotechnology 16 (1998), S. 598-599 
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    Notes: [Auszug] Biotechnology has thrown a powerful spotlight on the complex and changing nature of society's expectations for universities. On the one hand, society wants universities to serve as the repository of knowledge, pass along knowledge to students, and promote discovery that extends the frontiers of ...
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    Editorial clarification (1998)
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    Nature biotechnology 16 (1998), S. 601-601 
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    Notes: [Auszug] In an editorial in the June issue of Nature Biotechnology (16:491) “Keeping the story straight,” sponsorship of a bill allowing for the development of an integrated database for gene discovery research on the Icelandic population (“bill on medical databases”) was attributed ...
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    IGF in the clinic (1998)
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    Nature biotechnology 16 (1998), S. 601-602 
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    Notes: [Auszug] To the editor: In response to John Fowlkes' letter concerning my “one-sided analysis” of IGF-1 in the March issue, I would propose that in fact it is his analysis which is biased in favor of the drug. In my article, I presented the research of numerous scientists who had used IGF-1 in ...
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    The hydropathic binary code: A tool in genomic research? (1998)
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    Nature biotechnology 16 (1998), S. 601-601 
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    Notes: [Auszug] To the editor: An editorial in the June issue addressed the implications of the new genomic company planned by Perkins-Elmer and Craig Venter which will complete sequencing of the human genome within three years. This acceleration of the sequencing job will increase the pressure for academic and ...
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    Chloroplast-transgenic plants: Panacea-No! Gene Containment-Yes! (1998)
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    Nature biotechnology 16 (1998), S. 602-602 
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    Notes: [Auszug] To the editor: It is unfortunate that Stewart and Prakash have missed the point of maternal inheritance of foreign genes in MOST crops, when .they are engineered via the chloroplast genome. Such false and irresponsible statements, solely based on speculation and cursory knowledge or understanding ...
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    Business and Regulatory News (1998)
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    Nature biotechnology 16 (1998), S. 603-605 
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    Notes: [Auszug] Swiss reject gene ban On June 7, Swiss voters overwhwlmingly rejected a proposal for a moratorium on the cultivation of genetically modified crops and bans on research on transgenic animals and the patenting of genetically modified organisms. Althrough the turnout was low (∼40%), almost ...
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    Research News (1998)
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    Nature biotechnology 16 (1998), S. 606-606 
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    Notes: [Auszug] Rolling circles stay put With the help of a novel enzyme and a clever DNA. microarray-based assay, researchers at Yale University School of Medicine (New Haven, CT) and Oncor (Gaithersburg, MD) have developed a system that can detect rare single base changes in a large pool of DNA. The approa uses ...
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    This Month in Nature Biotechnology (1998)
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    Nature biotechnology 16 (1998), S. 607-607 
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    Notes: [Auszug] Designer blood Engineered hemoglobin—artificial blood—is currently in the clinic, but hurdles remain to its wide application. One problem is'ironically due to its extreme purity. In ischemia, caused by the lack of oxygen, hypoxanthine and xanthine oxidase are produced. When the ...
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    PE/TIGR provokes genome sequencing skeptics (1998)
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    Nature biotechnology 16 (1998), S. 610-611 
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    Notes: [Auszug] The announcement in May by Perkin-Elmer (PE, Norwalk, CT) and The Institute for Genomic Research (TIGR, Rockville, MD) of the formation of a new commercial venture to “substantially” sequence the human genome in three years (Nature Biotechnology 16:491,1998) has been met with some ...
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    Activities Challenge FDA food policy (1998)
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    Nature biotechnology 16 (1998), S. 611-612 
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    Notes: [Auszug] Late this spring a coalition that included anti-biotechnology activists, religious leaders, consumer groups, scientists, and several noted chefs filed a detailed lawsuit at the US Federal District Court in Washington, DC, against the US Food and Drug Administration (FDA; Rockville, MD), claiming ...
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    Genomica set to score twice (1998)
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    Nature biotechnology 16 (1998), S. 610-610 
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    Notes: [Auszug] Beneath the headline genome sequencing squabbles, a number of companies are finding a niche developing software to mine the copious data produced by the gene sequencing and functional genomics enterprise. In the past year or so, companies such as NetGenics (Cleveland, OH), Molecular Informatics ...
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    Despite size difference, Monsanto, AHP to merge (1998)
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    Nature biotechnology 16 (1998), S. 612-613 
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    Notes: [Auszug] Early in June, American Home Products (AHP, Madison, NJ) and Monsanto (St. Louis, MO) announced they were combining forces. This has been variously presented as an acquisition of Monsanto by AHP, a “merger of equals,” or even a reverse takeover of AHP by Monsanto. John Stafford of AHP ...
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    Concern mounts over Munich's BioRegio money (1998)
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    Nature biotechnology 16 (1998), S. 614-615 
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    Notes: [Auszug] There are huge and worrying differences in the ways the three “winning” regions in Germany's BioRegio competition are allocating funding to stimulate biotechnology initiatives. The focus of most concern is Bavaria, the region around Munich that is widely regarded as Germany's most ...
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    Genentech's anticancer Mab expected by November (1998)
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    Nature biotechnology 16 (1998), S. 615-615 
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    Notes: [Auszug] Herceptin, Genentech's (S. San Francisco, CA) humanized monoclonal antibody that targets the HER2/neu receptor, and a HER2 diagnostic kit could both be marketed for breast cancer in the United States by November. Results from two phase III trials of Herceptin for the treatment of aggressive ...
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    Biotech–biotech company mergers puzzle investors (1998)
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    Nature biotechnology 16 (1998), S. 616-616 
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    Notes: [Auszug] Later this month, genomics specialist Incyte Pharmaceuticals (Palo Alto, CA) is expected to release the first product directly resulting from the company's December 1997 acquisition of Synteni (Fremont, CA). RatGEM is the first of nine chips based on Synteni's microarray technology that are due for ...
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    When blind is better: Protein design by evolution (1998)
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    Nature biotechnology 16 (1998), S. 617-618 
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    Notes: [Auszug] The road to wisdom? Well, it's plain and simple to express: Err and err and err again but less and less and less. PietHem, quoted in Darwin's dangerous idea: Evolution and the meanings of life Simon 6- Schuster, New York, p. 200. According to Darwin's staunchest supporters, all ...
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    From cows stem therapies? (1998)
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    Nature biotechnology 16 (1998), S. 620-621 
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    Notes: [Auszug] The embryonic stem (ES) cell has been a remarkably successful tool for creating transgenic and knockout animals. Indeed, genetic manipulation of ES cells remains the only routine method of carrying out specific genetic targeting (homologous recombination) at precise chromosomal locations in mice. ...
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    A freeze-dryer and a fertile imagination (1998)
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    Nature biotechnology 16 (1998), S. 618-619 
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    Notes: [Auszug] Only the most robust sperm can complete the long and arduous journey to the egg. Just how tough these little packages of DNA are has now become apparent in experiments reported in this issue by Wakayama and Yanagimuchi1. These authors were able to freeze-dry mouse sperm, keep them at room ...
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    Swell plant parasite plays host to chemical reactions (1998)
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    Nature biotechnology 16 (1998), S. 623-623 
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    Notes: [Auszug] A recent paper in Nature1 demonstrates that a plant virus capsid can serve as a host for both molecular containment and industrially relevant chemical reactions. By controlling the size of pores in a viral coat using pH-dependent gating, researchers have succeeded in mineralizing two ...
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    Artificial blood: Ancient dream, modern enigma (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 621-622 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] “… one must accept the results of experiments as they come, with all their unexpectedness and irregularity.” Claude Bernard, 18591 The relationship of blood to health has an almost mystical quality, deeply rooted in the history of medicine. As theories about blood function ...
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    Structural genomics: Bioinformatics in the driver's seat (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 625-627 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] “Structural genomics” is not simply the latest piece of investor jargon. It describes the high-throughput generation of new protein structures and their analysis in the context of emerging genome sequence data. The term was first used in the context of solving structures across whole ...
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    Developmental biology's impact on drug development (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 628-631 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Editor's Note: Nature Biotechnology's conference, "PharmacoGenesis: Postgenomic Drug Discovery Through Developmental Biology," included a roundtable discussion on building the infrastructure for developmental biology applications for the pharmaceutical industry. The following ...
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    In a fly's eye (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 630-630 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] How can the development of the compound eye in flies be related to the genesis of tumors in humans? ”Many of the components of the core biological processes of developmental and physiological functions are well conserved between invertebrates and humans“ explains Gerald Rubin, Howard ...
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    The emergence of flow cytometry for sensitive, real-time measurements of molecular interactions (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 633-638 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The analysis of macromolecular interactions is an essential element of biomedical research. Flow cytometry is uniquely capable of making sensitive and quantitative measurements of molecular interactions. These measurements can be made in real time with subsecond kinetic resolution using purified ...
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    Development of normal mice from oocytes injected with freeze-dried spermatozoa (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 639-641 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Freeze-dried mouse spermatozoa are all motionless and dead in the conventional sense. When injected into oocytes, however, their nuclei can support normal embryonic development even after three month preservation in a dried state. Although the freeze-drying protocol reported here will need further ...
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    Trasgenic bovine chimeric offspring produced from somatic cell-derived stem-like cells (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 642-646 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] We have developed a method, using nuclear transplantation, to produce transgenic embryonic stem (ES)-like cells from fetal bovine fibroblasts. These cells, when reintroduced into preimplantation embryos, differentiated into derivatives from the three embryonic germ layers, ectoderm, mesoderm, and ...
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    Production of biologically active salmon calcitonin in the milk of transgenic rabbits (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 647-651 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Salmon calcitonin (sCT) is an example of one of the many bioactive peptides that require amidation of the carboxy terminus for full potency. We describe a method for the production of amidated sCT in the mammary gland of transgenic rabbits. Expression of a fusion protein comprising human alpha ...
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    Man-made cell-like compartments for molecular evolution (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 652-656 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] Cellular compartmentalization is vital for the evolution of all living organisms. Cells keep together the genes, the RNAs and proteins that they encode, and the products of their activities, thus linking genotype to phenotype. We have reproduced this linkage in the test tube by transcribing and ...
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    Improved properties of FLP recombinase evolved by cycling mutagenesis (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 657-662 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The site-specific recombinases FLP and Cre are useful for genomic engineering in many living systems. Manipulation of their enzymatic properties offers a means to improve their applicability in different host organisms. We chose to manipulate the thermolabilty of FLP recombinase. A lacZ-based ...
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    Enhanced degradation of polychlorinated biphenyls by directed evolution of biphenyl dioxygenase (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 663-666 
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    Notes: [Auszug] Biphenyl dioxygenases (BP Dox) from different organisms, which are involved in the initial oxygenation and subsequent degradation of polychlorinated biphenyls (PCB), are similar in structure but have different functions. The large subunit of BP Dox, encoded by the bphA1 gene, is crucial for ...
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    Polyhemoglobin-superoxide dismutase-catalase as a blood substitute with antioxidant properties (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 667-671 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] Polyhemoglobin-superoxide dismutase-catalase is designed to function as an oxygen carrier with antioxidant properties. This is based on cross-linking hemoglobin with superoxide dismutase and cata-lase (PolyHb-SOD-CAT). This study describes the structural and antioxidant properties of this solution. ...
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    Rate of reaction with nitric oxide determines the hypertensive effect of cell-free hemoglobin (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 672-676 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Administration of extracellular hemoglobin-based oxygen carriers often induces mild increases in blood pressure. In order to test whether nitric oxide (NO) scavenging is responsible for the hypertensive effect, we constructed and tested a set of recombinant hemoglobins that vary in rates of ...
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    Building the proper foundation for genomics-based patents (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 683-684 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] With most of the world's drug development companies gearing up for genomics-based drug discovery, it is important to step back and gauge the type of intellectual property (IP) protection that will be available for these pioneering discoveries. At present, the legal system is moving in a direction ...
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    Recent patent applications in combinatorial chemistry (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 685-685 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] Patent # Subject Assignee Author Date Subject GB 2317175 Deuterated protecting groups for amino acids; used in combinatorial chemistry for monitoring solid-phase chemical reactions and for monitoring yields of reactions involving solid-phase bound reagents. Zeneca (Devon, UK) Pivonka DE, Russell ...
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    An efficient route to human bispecific IgG (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 677-681 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] Production of bispecific IgG (BsIgG) by coexpressing two different antibodies is inefficient due to unwanted pairings of the component heavy and light chains. To overcome this problem, heavy chains were remodeled for heterodimerization using engineered disulfide bonds in combination with previously ...
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    Next-generation web sites for research and investing (1998)
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    Nature biotechnology 16 (1998), S. 686-687 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Biotechnology companies and investors are rethinking the way the web can help manage their businesses.We all know that the web is changing the way we do business. TV commercials tell us so, after all. But how, exactly? All sorts of industries are taking advantage of the technology. Amazon.com, for ...
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    New Products (1998)
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    Nature biotechnology 16 (1998), S. 688-688 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Centrifuges Swinging rotor A new centrifuge from Heraeus (Hanau, Germany) has a swing-out rotor but remains low cost. The Labofuge 300 is especially useful for the centrifugation of blood collection tubes with a gel barrier, often used for the testing of viral particles in the sample. The ...
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    People (1998)
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    Nature biotechnology 16 (1998), S. 689-689 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Genome Pharmaceuticals (Munich, Germany) has announced the appointment of Metin Colpan to its supervisory board. Dr. Colpan is cofounder, CEO, and president of Qiagen NV. He will take the board seat vacated by Hans Lehrach, one of Genome Pharmaceuticals' scientific founders. Leonard R. Borrmann ...
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    Combinatorial chemistry (1998)
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    Nature biotechnology 16 (1998), S. 691-693 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] A little over a year ago, Nature Biotechnology published the first-ever map of the combinatorial chemistry universe based on data gathered by the author of this column1. Since that time, both the biotechnology and pharmaceutical industries have continued to recognize combinatorial chemistry as a ...
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    Gene knockouts galore (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 519-520 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The human genome effort has several goals. One of them is the generation of the complete nucleotide sequence, which is slated for completion at the end of 2005. In the meantime, efforts are under way to construct cDNA libraries, sequence portions of them, and deposit the 3′- or 5′-end ...
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    Postgenomic protein analysis: The next bend in the river (1998)
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    Nature biotechnology 16 (1998), S. 520-521 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] It seems that every few months brings another postgenomic conference, and with it a view of the next beftd in the river rushing toward the future of genomics research. A recent meeting in San Francisco* may have given us a glimpse of one such bend. If that view holds true, the next few years ...
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    Valuing biotechnology assets (1998)
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    Nature biotechnology 16 (1998), S. 525-529 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] This article, the first in a two-article series, reviews some reliable ways for sophisticated companies to identify investment opportunities. The object of any capital budgeting decision is to maximize the value of the firm through the identification of strategic investment projects that create ...
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    Questions from a scientific audience: How do I get started? (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 522-524 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Starting a biotechnology company appears to be diametrcially opposed to running a lab on all counts but one: Surrounding yourself with the best people you can find. Editor's Note: A recent Nature Biotechnology conference, PharmacoGenesis: Postgenomic Drug Discovery Through Developmental ...
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    The insects are coming (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 530-533 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] For the first time, foreign genes have been inserted into insect species other than the fruit fly, setting the stage for applications outside of the laboratory.An impressive list of animals is now amenable to foreign gene transfer, including worms, frogs, fish, chickens, mice, rabbits, goats, ...
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    Human antibodies by design (1998)
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    Nature biotechnology 16 (1998), S. 535-539 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Monoclonal antibodies (Mabs) have long been considered a good class of natural drugs, both because they mimic their natural role in the body and because they have no inherent toxicity. Although rodent Mabs are readily generated, their widespread use as therapeutic agents has been hampered because ...
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    NIH peer review: Time for some changes (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 395-395 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] US universities guarantee academic freedom to scholars who have demonstrated their professional excellence by means of a tenure system that protects them from reigning intellectual and political pressures. But in the biomedical sciences, tenure has lost much of its meaning since the cost of ...
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    Taking stock of scientific fraud (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 395-395 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The potential for conflict of interest by academic researchers now extends into a realm of outright fraud that is very much the biotechnology industry's business—and should make biotechnology executives and industry officials active partners in setting standards to help curb such behavior. ...
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    Telomerase and cellular lifespan: Ending the debate? (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 396-397 
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    Notes: [Auszug] Gerontology received a strong stimulus in the early 1960s when it was established that mass cultures of fetal human fibroblasts would undergo no more than about 50 population doublings in cell culture1,2. Studies of three clones indicated to the author that this was characteristic of all the ...
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    Letter 2: Chloroplast-transgenic plants are not a gene flow panacea (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 401-401 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] There is chloroplast gene flow through pollen in higher plants. Two articles in Nature Biotechnology1-2 make the blanket claim that there is a lack of gene flow through pollen. The original research was done with tobacco in which there is clear evidence of gene flow through tobacco pollen under ...
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    Letter 1: Chloroplast-transgenic plants are not a gene flow panacea (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 401-401 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The assertion has been made recently by Daniell et al.' that chloroplast (cp) transformation will be a practical solution to the problem of crop transgenes flowing to related weeds. This is an overstatement. They argued that transformed cp DNA, which they apparently assumed to be exclusively ...
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    Agriculture: Biotechnology and food security for the 21st century: A real-world perspective (1998)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 399-400 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Despite long-standing concerns about balancing population and food supplies, and many population control measures, world population continues to grow at about 1.5% a year, and is projected to reach 8 billion by 2020, and 11 billion by 2050. Almost all of this growth will occur in the already ...
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