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  • pharmacokinetics  (182)
  • Atmosphere-ocean system
  • Salinity
  • Springer  (191)
  • American Meteorological Society  (2)
  • Woods Hole Oceanographic Institution  (2)
  • WOCE Hydrographic Programme Offce, Woods Hole Oceanographic Institution  (1)
  • Springer Nature
  • 2005-2009  (5)
  • 1975-1979  (191)
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  • 1
    Publikationsdatum: 2017-04-04
    Beschreibung: In this paper results from the application of an ocean data assimilation (ODA) system, combining a multivariate reduced-order optimal interpolator (OI) scheme with a global ocean general circulation model (OGCM), are described. The present ODA system, designed to assimilate in situ temperature and salinity observations, has been used to produce ocean reanalyses for the 1962–2001 period. The impact of assimilating observed hydrographic data on the ocean mean state and temporal variability is evaluated. A special focus of this work is on the ODA system skill in reproducing a realistic ocean salinity state. Results from a hierarchy of different salinity reanalyses, using varying combinations of assimilated data and background error covariance structures, are described. The impact of the space and time resolution of the background error covariance parameterization on salinity is addressed.
    Beschreibung: This work has been funded by the ENACT Project (Contract EVK2-CT2001-00117) for A. Bellucci and P. Di Pietro, and partially by the ENSEMBLES Project (Contract GOCE-CT-2003-505539) for A. Bellucci.
    Beschreibung: Published
    Beschreibung: 3785-3807
    Beschreibung: 3.7. Dinamica del clima e dell'oceano
    Beschreibung: JCR Journal
    Beschreibung: reserved
    Schlagwort(e): ocean modelling ; data assimilation ; reanalysis ; upper ocean variability ; temperature ; Salinity ; 03. Hydrosphere::03.01. General::03.01.04. Ocean data assimilation and reanalysis
    Repository-Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Materialart: article
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
    facet.materialart.
    Unbekannt
    American Meteorological Society
    Publikationsdatum: 2021-05-19
    Beschreibung: Skill in ensemble-mean dynamical seasonal climate hindcasts with a coupled land-atmosphere model and specified observed sea surface temperature is compared to that for long multi-decade integrations of the same model where the initial conditions are far removed from the seasons of validation. The evaluations are performed for surface temperature and compared among all seasons. Skill is found to be higher in the seasonal simulations than the multi-decadal integrations except during boreal winter. The higher skill is prominent even beyond the first month when the direct influence of the atmospheric initial state elevates model skill. Skill is generally found to be lowest during the winter season for the dynamical seasonal forecasts, equal to that of the long integrations, which show some of the highest skill during winter. The reason for the differences in skill during the non-winter months is attributed to the severe climate drift in the long simulations, manifest through errors in downward fluxes of water and energy over land and evident in soil wetness. The drift presses the land surface to extreme dry or wet states over much of the globe, into a range where there is little sensitivity of evaporation to fluctuations in soil moisture. Thus, the land-atmosphere feedback is suppressed, which appears to lessen the model’s ability to respond correctly over land to remote ocean temperature anomalies.
    Beschreibung: Center for Ocean-Land-Atmosphere Studies
    Beschreibung: Published
    Schlagwort(e): Atmosphere-ocean system
    Repository-Name: AquaDocs
    Materialart: Journal Contribution , Refereed , Article
    Format: 503454 bytes
    Format: application/pdf
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  • 3
    Publikationsdatum: 2022-05-25
    Beschreibung: This report describes calibration techniques developed over the past three years for the WHOI/Brown CTD in the Moored Array Program. Comparison is made with classical methods of hydrography for stations obtained in the MODE-1 density program. Methods for temperature lag correction and conversion of conductivity to salinity are given.
    Beschreibung: Prepared for the Office of Naval Research under Contract N00014-74-C0262; NR 083-004.
    Schlagwort(e): CTD ; Calibration ; Salinity
    Repository-Name: Woods Hole Open Access Server
    Materialart: Technical Report
    Format: 3977131 bytes
    Format: application/pdf
    Standort Signatur Erwartet Verfügbarkeit
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  • 4
    facet.materialart.
    Unbekannt
    Woods Hole Oceanographic Institution
    Publikationsdatum: 2022-05-26
    Beschreibung: Originally issued as Reference No. 59-54
    Beschreibung: In August and September 1958 a number of oceanographic sections were made in the R.R.S. DISCOVERY II, Captain James Gray, under the scientific leadership of H. F. P. Herdman. These sections comprise part of a joint program undertaken by the National Institute of Oceanography and the Woods Hole Oceanographic Institution for the International Geophysical Year.
    Beschreibung: The United States participation in this program was supported by the Office of Naval Research Contract Nonr 2196(00) with the Woods Hole Oceanographic Institution.
    Schlagwort(e): Discovery II (Ship) International Geophysical Year Cruise 3 ; Ocean temperature ; Echo sounding ; Chemical oceanography ; Salinity
    Repository-Name: Woods Hole Open Access Server
    Materialart: Technical Report
    Format: application/pdf
    Standort Signatur Erwartet Verfügbarkeit
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  • 5
    Publikationsdatum: 2022-05-26
    Beschreibung: This report summarizes the work, under the auspices of the WOCE Hydrographic Programme (WHP), which took place on the R/V Akademik Vernadsky in June-July 1991. The goal of the exercise was an international comparison/training cruise to obtain comparisons of water sampling methods and analytical techniques employed by several groups for the oceanographic measurement of salinity and oxygen in seawater. The training aspect was formalized in a pre-cruise practicum held on board the vessel by Dr. Fred Culkin and Mr. Paul Ridout of Ocean Scientific International, the manufacturer of IAPSO Standard Seawater, At-sea comparisons of Russian Reference Water, manufactured in Moscow, were made with IAPSO water. Further work involved comparisons of a Guildline and a pair of SOKOL salinometers using reference water and natural seawater collected on the cruise. While the agreement among the salnometers was quite good and at the level of acceptability for the WHP, it was discovered that lack of thermal equilbration of the salinity samples run on the SOKOLs led to substantial "errors" at large depths (or for cold water samples). This could not have been anticipated before the cruise and would have been missed in a shore-based or laboratory exercise. All five groups making oxygen comparisons benefitted from the technical exchange afforded by the cruise and, as a result of reconciling inter-group differences, have identified procedural changes they wil make in the future in order to achieve the high standards required by the WHP, The technical interaction, which amounted to "training" for all groups, was greatly facilitated by the cooperation of Captain Malnovsky, Chief Scientist Panteleyev, the scientists from MHI, Sevastopol, and the crew of the Vernadsky. On the Vernadsky comparison cruise, a shore-based practicum was held prior to sailing in order to review the theory and measurement of salinity. The cruise itself, which took place between 27 June and 8 July 1991, was in the NE Atlantic to the west of Madeira. An international group of experts in salnity and oxygen measurements was drawn from the United Kingdom (UK), Spain, Russia, Ukraine, and the United States (US). Except for one of the five groups, measured oxygen values in the range of 3-5 mIll (concentration units are used throughout) agreed with one another within :11%, which exceeds the WOCE requirements by a factor of 2. Subsequent analyses of the differences by all five groups could account for much of the observed inter-group variations, Intra-group precision was generally in the range of 0,1-0.4%, As a result, of a low oxygen sparging experiment in which sample oxygens 0: 1.2 mIll were generated, substantial inter-group differences of :1.08 mIll were found indicating that oxygen specifications for WOCE need to be expressed as both a percent "error" and a low oxygen bias. The salinity comparison component of the cruise enabled comparison of various batches of Russian Reference Water (RRW) of various salnities (10, 20, 30, 35 and 40) against IAPSO Standard Seawater (SSW) of various salinities (10, 30, 35 and 38); inferences could then also be drawn on the relative performance of the two types of salinometer (Guildline Autosal 8400 and SOKOL 4602) used during the experiment. Under quasilaboratory conditions, the machines produced mean results different by no more than 0.001 in salinity for salinity 35 RRW, standardizing against salinity 35 SSW. The other salnities produced less conclusive results, but the three salinometers deviated by no more than 0.003 from the expected value over a wide range of salinities. Under operational conditions (analysis of duplicate samples collected from CTD casts) a mean bias emerged between machines of approximately 0.005 in salinity (SOKOL fresher than Guildline), Subsequent investigations tentatively ascribed this bias to non-equilbration of deep (cold) samples in the Russian system.
    Beschreibung: Prepared for the National Science Foundation under Grants OCE89-07815, and OCE92-06184, T. Joyce, Principal Investigator; Vetlesen Funds, Woods Hole Oceanographic Institution; and with support from the Intergovernmental Oceanographic Commission.
    Schlagwort(e): Vernadsky (Ship) ; World Ocean Circulation Experiment ; Oxygen ; Salinity ; Oceanography ; Measurement
    Repository-Name: Woods Hole Open Access Server
    Materialart: Working Paper
    Format: 3230770 bytes
    Format: application/pdf
    Standort Signatur Erwartet Verfügbarkeit
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  • 6
    Digitale Medien
    Digitale Medien
    Springer
    European journal of clinical pharmacology 8 (1975), S. 97-105 
    ISSN: 1432-1041
    Schlagwort(e): Di-n-propylacetate ; 2-propyl-valeric acid sodium salt ; pharmacokinetics ; anti-epileptic ; drug monitoring ; man
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary The pharmacokinetics of the anti-epileptic drug di-n-propylacetate (DepakineR) have been studied in 7 patients, in whom plasma concentrations were determined during and following subchronic treatment. Elimination of the drug appeared to follow a monophasic exponential course; biological half lives were 8 to 15 hours. The data supported the assumption that an open one-compartment model can be used to describe the kinetics of dipropylacetate in man. The drug appeared to have a relatively restricted distribution: calculated relative distribution volumes ranged from 0.15 to 0.40 1/kg. There were large interindividual differences in clearance rate. The therapeutic range was considered to be between 50 and 100 mg/1 plasma. Plasma levels of phenobarbital were markedly raised during treatment with dipropylacetate for an unknown reason. Determination of the plasma concentrations of drugs at accurately fixed times appears to be a reliable method for pharmacotherapeutic monitoring of epileptic patients.
    Materialart: Digitale Medien
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  • 7
    Digitale Medien
    Digitale Medien
    Springer
    European journal of clinical pharmacology 8 (1975), S. 157-160 
    ISSN: 1432-1041
    Schlagwort(e): Isosorbide dinitrate ; pharmacokinetics ; metabolism ; pharmacological action ; nitrates
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary An oral dose of 5 mg of14C-isosorbide dinitrate was rapidly absorbed, biotransformed and excreted by human subjects. Peak whole blood concentrations of radioactivity were reached after 1.5 to 2 hours and declined relatively slowly. The radioactivity in whole blood mainly represented metabolites, isosorbide mononitrates. The peak concentrations found were 4.5, 11.7 and 34.3 ng/ml of isosorbide dinitrate, isosorbide 2-mononitrate and isosorbide 5-mononitrate, respectively, in the blood of one subject and 5.9, 15 and 61.3 ng/ml, respectively, in the blood of another subject. However, concentrations of the metabolites declined relatively slowly during 6 h after the oral dose. Up to 99% of an oral dose of isosorbide dinitrate was excreted during 5 days, mainly in the urine of the first day (ca. 78%). The results showed that isosorbide mononitrates were available to contribute to the pharmacological action.
    Materialart: Digitale Medien
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  • 8
    Digitale Medien
    Digitale Medien
    Springer
    European journal of clinical pharmacology 8 (1975), S. 241-248 
    ISSN: 1432-1041
    Schlagwort(e): pharmacokinetics ; experimental design
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary It is apparent from studying recent articles on pharmacokinetics that a number of misunder-standings exist, both about the design of experiments and the analysis of results. The purpose of this paper is to outline many of the common pitfalls associated with the design of experiments and also the limitations upon the analysis of results. The paper describes mathematical, laboratory and clinical aspects which must be examined in designing a protocol for pharmacokinetic experiments. Simulated data is presented to demonstrate the dangers of using standard computer programs for parameter estimation. Even when convergence is obtained the answers may be dependent on the method employed. A mathematical model is of little use unless a reasonable amount of good, accurate data is obtained.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 9
    Digitale Medien
    Digitale Medien
    Springer
    European journal of clinical pharmacology 8 (1975), S. 249-254 
    ISSN: 1432-1041
    Schlagwort(e): Clonazepam ; 7-amino-clonazepam ; pharmacokinetics ; side-effects ; man
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary Clonazepam (CNP) and its principal metabolite in plasma, 7-amino-CNP (ACNP), have been investigated in a prospective study of 27 newly diagnosed epileptics and correlated with specified side-effects. At a daily dose of 6 mg, the average plasma levels of both substances were about 50ng/ml, and individual values ranged from 30 to about 80ng/ml. There was a linear correlation between changes in dose and the resulting plasma levels, which indicates first order elimination kinetics. Side-effects were frequent, but neither their severity nor their occurrence could be related to plasma levels or to the rate of increase in plasma concentration of the drug. Three out of five patients who developed serious dysphoria had significantly high CNP levels. The concentration of ACNP was considerably increased in four patients who subsequently suffered from withdrawal symptoms. Drug interaction with diphenylhydantoin, i.e. decreased CNP level, was observed in all five patients who received both compounds. In general it is not yet possible to define an upper limit for the plasma levels of CNP and ACNP at which toxicity occurs. In patients treated with conventional doses of CNP, measurement of plasma concentration is not required, except in special circumstances, because of the lack of correlation between plasma level and side-effects.
    Materialart: Digitale Medien
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  • 10
    Digitale Medien
    Digitale Medien
    Springer
    European journal of clinical pharmacology 8 (1975), S. 271-275 
    ISSN: 1432-1041
    Schlagwort(e): Fluorophenindione ; vitamin K antagonist ; pharmacokinetics ; loading dose ; anticoagulant
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary After administration of a single loading dose (80 mg p.o.) of fluorophenindione, the prothrombin level decreased to 37 % in 24 h, and the effect lasted for 48 h. Accordingly, fluorophenindione can be classified as an anticoagulant with an “intermediate” effect. Its elimination half-life was 31 h, which is longer than that of phenindione, because of the greater stability of the fluorinated derivate.
    Materialart: Digitale Medien
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