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  • Wiley  (243.500)
  • American Association for the Advancement of Science  (79.062)
  • Nature Publishing Group  (78.299)
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  • 1
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    Wiley
    In:  EPIC3The Ocean Floor : Bruce Heezen commemorative volume, (A Wiley-Interscience publication), Chichester, Wiley, pp. 147-163, ISBN: 0-471-10091-9
    Publikationsdatum: 2014-05-12
    Beschreibung: The sedimentation regime off Northwest Africa is shaped by: (1) structur~al factors. which result in generallv low relief on land. shelf widths between 40 and more than 120 km. and av-erage sfope inclinations between 10 30' and 30; (2) land climates. which contral the delivery of terrigenous particles to the margin: (3) water movements including boundary currents and upwelling; and (4) the post- Pleistocene sea level rise. This chapter combines published and new results arising from research into the sedimentation processes off Northwest Africa. and emphasizes particularly the activities of the Kiel marine geological group during the past few years. Reviews of cruise activities and results were given in Closs et al. (1969) (Meteor cruise 8. 1967. off Morocco) . Seibold (1972) (Meteor cmise 25 . 1971. off Sahara to Central Senegal). Seibold and Hinz (1976) (Meteor cmise 39,1975 . and Valdivia cruise 10. 1975, from Morocco to South Senegal), and Waiden et al. (1974) (Meteor cmise 30, 1973, off Sierra Leone). Some of these cmises were used for pre- or post-site surveys for the Deep-Sea Drilling Project, or to add undisturbed Quaternary cores to the Glomar Challenger cores (leg 41, ] 975; Lancelot, et al .• 1978); leg 47 A, Arthur er al .• 1979; Lutze et al., 1979). We have concentrated our geological investigations on a number of standard profiles from the shelf to the upper continental rise as given in Figure 1. The manuscript was finished May 1979.
    Repository-Name: EPIC Alfred Wegener Institut
    Materialart: Inbook , peerRev
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  • 2
    facet.materialart.
    Unbekannt
    Wiley
    In:  EPIC3Geophysical Research Letters, Wiley, 32(L10618), ISSN: 0094-8276
    Publikationsdatum: 2018-12-07
    Repository-Name: EPIC Alfred Wegener Institut
    Materialart: Article , isiRev
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  • 3
    Publikationsdatum: 2016-01-18
    Beschreibung: From a synthesis of recent oceanic observations and paleo-data it is evident that certain species of giant diatoms including Rhizosolenia spp. Thalassiothrix spp. and Ethmodiscus rex may become concentrated at oceanic frontal zones and subsequently form episodes of mass flux to the sediment. Within the nutrient bearing waters advecting towards frontal boundaries, these species are generally not dominant, but they appear selectively segregated at fronts, and thus may dominate the export flux. Ancient Thalassiothrix diatom mat deposits in the eastern equatorial Pacific and beneath the Polar Front in the Southern Ocean record the highest open ocean sedimentation rates ever documented and represent vast sinks of silica and carbon. Several of the species involved are adapted to a stratified water column and may thrive in Deep Chlorophyll Maxima. Thus in oceanic regions and/or at times prone to enhanced surface water stratification (e.g., during meltwater pulses) they provide a mechanism for generating substantial biomass at depth and its subsequent export with concomitant implications for Si export and C drawdown. This ecology has important implications for ocean biogeochemical models suggesting that more than one diatom “functional type” should be used. In spite of the importance of these giant diatoms for biogeochemical cycling, their large size coupled with the constraints of conventional oceanographic survey schemes and techniques means that they are undersampled. An improved insight into these key species will be an important prerequisite for enhancing our understanding of marine biogeochemical cycling and for assessing the impacts of climate change on ocean export production.
    Repository-Name: EPIC Alfred Wegener Institut
    Materialart: Article , peerRev
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  • 4
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    American Association for the Advancement of Science
    Publikationsdatum: 2017-04-04
    Beschreibung: The continuous volcanic and seismic activity at Mount Etna makes this volcano an important laboratory for seismological and geophysical studies. We used repeated three-dimensional tomography to detect variations in elastic parameters during different volcanic cycles, before and during the October 2002–January 2003 flank eruption. Well-defined anomalous low P- to S-wave velocity ratio volumes were revealed. Absent during the pre-eruptive period, the anomalies trace the intrusion of volatile-rich (Q4 weight percent) basaltic magma, most of which rose up only a few months before the onset of eruption. The observed time changes of velocity anomalies suggest that four-dimensional tomography provides a basis for more efficient volcano monitoring and shortand midterm eruption forecasting of explosive activity.
    Beschreibung: Published
    Beschreibung: 821-823
    Beschreibung: reserved
    Schlagwort(e): NONE ; 04. Solid Earth::04.01. Earth Interior::04.01.02. Geological and geophysical evidences of deep processes ; 04. Solid Earth::04.06. Seismology::04.06.07. Tomography and anisotropy ; 04. Solid Earth::04.08. Volcanology::04.08.06. Volcano monitoring
    Repository-Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Materialart: article
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  • 5
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    American Association for the Advancement of Science
    Publikationsdatum: 2017-04-04
    Beschreibung: BREVIA
    Beschreibung: Current emission inventories require an additional "unknown" source to balance the global atmospheric budgets of ethane (C2H6). Here, we provide evidence that a substantial part of the missing source can be attributed to natural gas seepage from petroliferous, geothermal, and volcanic areas. Such geologic sources also inject propane (C3H8) into the atmosphere. The analysis of a large data set of methane (CH4), ethane, and propane concentrations in surface gas emissions of 238 sites from different geographic and geologic areas, coupled with published estimates of geomethane emissions, suggests that Earth's degassing accounts for at least 17% and 10% of total ethane and propane emissions, respectively.
    Beschreibung: Published
    Beschreibung: 478
    Beschreibung: 3.8. Geofisica per l'ambiente
    Beschreibung: JCR Journal
    Beschreibung: reserved
    Schlagwort(e): Ethane ; Propane ; Geologic emissions ; Seepage ; 03. Hydrosphere::03.04. Chemical and biological::03.04.05. Gases
    Repository-Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Materialart: article
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  • 6
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    American Association for the Advancement of Science
    Publikationsdatum: 2017-04-04
    Beschreibung: Episodes of nonvolcanic tremor and accompanying slow slip recently have been observed in the subduction zones of Japan and Cascadia. In Cascadia, such episodes typically last a few weeks, and differ from “normal” earthquakes in their source location and momentduration scaling. The three most recent episodes in the Puget Sound/Southern Vancouver Island portion of the Cascadia subduction zone have been exceptionally well recorded. In each episode, we see clear pulsing of tremor activity with periods of 12.4 and 24-25 hours, the same as the principal lunar and lunisolar tides. This indicates that the small stresses associated with the solid-earth and ocean tides influence the genesis of tremor much more effectively than they do “normal” earthquakes. Because the lithostatic stresses are 105 times larger than those associated with the tides, we argue that tremor occurs on very weak faults.
    Beschreibung: Published
    Beschreibung: 186 -189
    Beschreibung: 3.1. Fisica dei terremoti
    Beschreibung: JCR Journal
    Beschreibung: reserved
    Schlagwort(e): Nonvolcanic ; tremor ; 04. Solid Earth::04.06. Seismology::04.06.01. Earthquake faults: properties and evolution ; 04. Solid Earth::04.06. Seismology::04.06.02. Earthquake interactions and probability ; 04. Solid Earth::04.06. Seismology::04.06.03. Earthquake source and dynamics
    Repository-Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Materialart: article
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  • 7
    Publikationsdatum: 2019-07-17
    Beschreibung: A continuous high-resolution record of digital images has been obtained from the North Greenland Ice Core Project (NorthGRIP) ice core (75.1N, 42.3W) in the depth interval from 1330 m to the bedrock at 3085 m. The ice core stratigraphy is clearly visible throughout the glacial period with the most frequent and brightest visible layers appearing during the coldest events. Down to a depth of 2600 m the horizontal layeringis very regular; below this depth, small irregularities in the layering start to appear, and below 2800 m the visual stratigraphy becomes more uncertain, perhaps because of penetration into climatically warmer ice. Comparison of the visual stratigraphy with high-resolution continuous records of chemical impurities and dust reveals a high degree of correlation, which indicates that the visible layers are caused by these impurities. Anew approach is used to automatically determine annual layer thicknesses from the visual stratigraphy record by carrying out a frequency analysis of the most prominent visible layers in the profile. The result gives strong support for the NorthGRIP timescale model.
    Repository-Name: EPIC Alfred Wegener Institut
    Materialart: Article , isiRev
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  • 8
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    Unbekannt
    Wiley
    In:  EPIC3The Ocean Floor, The Ocean Floor, Wiley, pp. 147-163
    Publikationsdatum: 2016-03-17
    Repository-Name: EPIC Alfred Wegener Institut
    Materialart: Inbook , peerRev
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  • 9
    Publikationsdatum: 2021-05-19
    Beschreibung: 1. Seahorses (Hippocampus spp.), many of which are listed as Vulnerable or Endangered on the IUCN Red List, are traded worldwide as souvenirs, aquarium fish and, primarily, for use in traditional medicines. Given concern over the sustainability of this trade, the genus was added to Appendix II of the Convention on International Trade in Endangered Species of Wild Fauna and Flora (CITES) in May 2004. 2. This paper reports findings of the first ever survey of seahorse trade in Africa, conducted in Kenya and Tanzania in May and June 2000. 3. Seahorse trade in Kenya was found to be negligible, with approximately 10 live seahorses exported as aquarium fish annually. Until 1998, however, Kenya may have imported somewhere from 1 to 2.3 t of dried seahorses annually from Tanzania for re-export to Asian medicine markets. Seahorse trade in Tanzania remained substantial, with at least 630–930 kg of dried seahorse exported directly to Asia each year. 4. Accounts of declines in seahorse availability and seahorse size, although few in number, could be early warning signs that wild populations are suffering, at least locally. Close monitoring of future developments in the trade will be essential to allow for timely conservation action as and when necessary, and would contribute to our understanding of the ecological and economical implications of small-scale, non-food fisheries. Copyright # 2004 John Wiley & Sons, Ltd.
    Beschreibung: Published
    Schlagwort(e): Hippocampus spp ; By catch ; Non-food fisheries ; Seahorse trade ; Endangered species ; Aquatic animals
    Repository-Name: AquaDocs
    Materialart: Journal Contribution , Non-Refereed , Article
    Format: 438174 bytes
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  • 10
    Publikationsdatum: 2022-05-26
    Beschreibung: © 2008 Nature Publishing Group. This article is distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike license. The definitive version was published in Nature Biotechnology 26 (2008): 909-915, doi:10.1038/nbt.1482.
    Beschreibung: Plant-parasitic nematodes are major agricultural pests worldwide and novel approaches to control them are sorely needed. We report the draft genome sequence of the root-knot nematode Meloidogyne incognita, a biotrophic parasite of many crops, including tomato, cotton and coffee. Most of the assembled sequence of this asexually reproducing nematode, totaling 86 Mb, exists in pairs of homologous but divergent segments. This suggests that ancient allelic regions in M. incognita are evolving toward effective haploidy, permitting new mechanisms of adaptation. The number and diversity of plant cell wall–degrading enzymes in M. incognita is unprecedented in any animal for which a genome sequence is available, and may derive from multiple horizontal gene transfers from bacterial sources. Our results provide insights into the adaptations required by metazoans to successfully parasitize immunocompetent plants, and open the way for discovering new antiparasitic strategies.
    Beschreibung: SCRI laboratory (V.C.B. and J.T.J.) received funding from the Scottish Government. This work benefited from links funded via COST Action 872. G.V.M. and V.L. are supported by ARC, CNRS, EMBO, MENRT and Region Rhone-Alpes. G.V.M., M.R.-R. and V.L. are also funded by the EU Cascade Network of Excellence and the integrated project Crescendo. M.-C.C. is supported by MENRT.
    Repository-Name: Woods Hole Open Access Server
    Materialart: Article
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  • 11
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 24 (2006), S. 1048-1049 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] 200% ethanol boost from Oz sugar University of Queensland (UQ), Australia, molecular geneticist Robert Birch got more than he bargained for when he introduced a bacterial gene into sugarcane to convert sucrose into its high-value isomer, isomaltulose. In fact, the gene encoding sucrose isomerase, ...
    Materialart: Digitale Medien
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  • 12
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 24 (2006), S. 1484-1485 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Common bacteria, engineered to safely seek out and kill tumors, may well be the next generation of cancer therapeutics. In this issue, Bettegowda et al. report the genome sequence of one such bacterium, Clostridium novyi-NT, which has been engineered to be non-toxic by deleting the major systemic ...
    Materialart: Digitale Medien
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  • 13
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 24 (2006), S. 1491-1493 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] This June, Basel-based Novartis Pharmaceuticals made a first reconnoiter into antimicrobial antibodies in its quest to find new weapons to fight infections. It paid $569 million to acquire NeuTec Pharmaceuticals of Manchester, UK, and its two late-stage products, both antibody fragments ...
    Materialart: Digitale Medien
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  • 14
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 24 (2006), S. 1504-1507 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] The scarcity of disease in wild plants indicates that the success of plant defense mechanisms in combating pathogen infection rivals that of mammalian immune systems. Although there are some interesting parallels between plant and animal defense strategies—for instance, both groups sacrifice ...
    Materialart: Digitale Medien
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  • 15
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 24 (2006), S. 1515-1519 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] The US Food and Drug Administration (FDA) has recently rejected new antibiotics for common infections citing the requirement that the drugs intended to treat non-serious infections prove superior to placebo rather than active controls. With the introduction of more stringent statistical criteria, ...
    Materialart: Digitale Medien
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  • 16
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 24 (2006), S. 1521-1528 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] For developers of antibacterial products, this century began very much on the wrong foot. The number of pharmaceutical companies chasing antibiotics continued to drop, few genuinely new antibiotics reached the clinic and investors remained lukewarm toward startups in this sector. But, despite ...
    Materialart: Digitale Medien
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  • 17
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 24 (2006), S. 1565-1567 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] A support vector machine (SVM) is a computer algorithm that learns by example to assign labels to objects. For instance, an SVM can learn to recognize fraudulent credit card activity by examining hundreds or thousands of fraudulent and nonfraudulent credit card activity reports. Alternatively, an ...
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  • 18
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Bacteriolytic anti-cancer therapies employ attenuated bacterial strains that selectively proliferate within tumors. Clostridium novyi-NT spores represent one of the most promising of these agents, as they generate potent anti-tumor effects in experimental animals. We have determined the 2.55-Mb ...
    Materialart: Digitale Medien
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  • 19
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 24 (2006), S. 1569-1571 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] The utility of blue fluorescent protein (BFP) has been limited by its low quantum yield and rapid photobleaching. A library targeting residues neighboring the chromophore yielded a variant with enhanced quantum yield (0.55 versus 0.34), reduced pH sensitivity and a 40-fold increase in ...
    Materialart: Digitale Medien
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  • 20
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 24 (2006), S. 1551-1557 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Short cationic amphiphilic peptides with antimicrobial and/or immunomodulatory activities are present in virtually every life form, as an important component of (innate) immune defenses. These host-defense peptides provide a template for two separate classes of antimicrobial drugs. Direct-acting ...
    Materialart: Digitale Medien
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  • 21
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 24 (2006), S. 1300-1300 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Is it possible that ImClone didn't do its homework on Erbitux's ...
    Materialart: Digitale Medien
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  • 22
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 24 (2006), S. 1303-1303 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] On the average report card a test score of three out of five would usually draw the comment 'could do better'. The admonishment to try harder was also given by some observers to Darmstadt-based Merck KGaA's surprise €10.6- ($13.2)-billion acquisition of Serono on September 21. Although ...
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  • 23
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 24 (2006), S. 1081-1081 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Biotech stocks can be white-knuckle volatile, but there is a way you can profit from, or insure against, such rapid and dramatic price changes. Through put and call options, you may not only make more profits, but also buy and sell 'protection' for your investments (with no need for 'knuckle' ...
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  • 24
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 24 (2006), S. 1095-1095 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Recent patent applications in tissue engineering ...
    Materialart: Digitale Medien
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  • 25
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 24 (2006), S. 1091-1094 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Gene patenting has attracted intense scrutiny for decades, raising a host of ethical, legal and economic concerns. Much of the policy debate has focused on seemingly quantifiable and practical concerns about the effect of patents on access to useful technologies in the contexts of both research and ...
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  • 26
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 24 (2006), S. 1322-1323 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] To the editor: One of the challenges for the future is how to integrate all the DNA microarray data that have been generated and deposited in public databases. We have studied data from two data repositories and identified that only 38% meet necessary quality and data format standards. Our results ...
    Materialart: Digitale Medien
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  • 27
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 24 (2006), S. 1097-1098 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Of the many differentiated cell types that have been derived in vitro from mouse embryonic stem (ES) cells, among the most intriguing are cells resembling male and female gametes. Such ES cell–derived germ cells have been shown to undergo meiosis to form haploid gametes that can support early ...
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  • 28
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 24 (2006), S. 1352-1354 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] The increasingly commercial nature of biomedical research is, rightly or not, a reality of the contemporary research environment. The percentage of biomedical research supported by industry continues to grow, and many public funding agencies now encourage industry partnerships. Although links with ...
    Materialart: Digitale Medien
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  • 29
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 24 (2006), S. 1359-1361 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Plant-derived 'essential oils' such as terpenoids are widely used in the fragrance and flavor industries. In this issue, Chappell and colleagues describe an approach for engineering plants that produce elevated levels of commercially relevant terpenoids. They co-express both an enzyme that supplies ...
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  • 30
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 24 (2006), S. 1365-1366 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] The rallying cry of early 21st century biomedical science is that new combinations of genomic, proteomic and bioinformatic research will provide deeper insights into disease mechanisms, novel markers for diagnostics and new molecular targets for therapeutic intervention. DNA and protein microarrays ...
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  • 31
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 24 (2006), S. 1374-1376 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Trying to make some sense of it all, But I can see that it makes no sense at all, Is it cool to go to sleep on the floor, 'Cause I don't think that I can take anymore Clowns to the left of me, jokers to the right, Here I am, stuck in the middle with you. Joe Egan and Gerry Rafferty There are ...
    Materialart: Digitale Medien
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  • 32
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 24 (2006), S. 1448-1448 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Nat. Biotechnol. 24, 397–400 (2006); published online 29 March 2006; corrected after print 8 November 2006. In the version of this article initially published, on page 399, column 2, paragraph 4, the authors wrongly credited the idea for using cells from nonviable human embryos as an ...
    Materialart: Digitale Medien
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  • 33
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Transcription factors (TFs) interact with specific DNA regulatory sequences to control gene expression throughout myriad cellular processes. However, the DNA binding specificities of only a small fraction of TFs are sufficiently characterized to predict the sequences that they can and cannot bind. ...
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 34
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Severe acute liver failure, even when transient, must be treated by transplantation and lifelong immune suppression. Treatment could be improved by bioartificial liver (BAL) support, but this approach is hindered by a shortage of human hepatocytes. To generate an alternative source of cells for BAL ...
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 35
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 24 (2006), S. 1377-1383 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] The recent influenza vaccine shortages have provided a timely reminder of the tenuous nature of the world's vaccine supply and the potential for manufacturing issues to severely disrupt vital access to important vaccines. The application of new technologies to the discovery, assessment, development ...
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 36
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 24 (2006), S. 1039-1039 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] No technology embodies the rise of 'omic' science more than the DNA microarray. First reduced to practice in the early 1990s, it has since undergone numerous iterations, adaptations and refinements to achieve its present status as the platform of choice for massively parallel gene expression ...
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 37
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 24 (2006), S. 1184-1184 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] One year on from the enforcement of Brazil's innovation law, the first national innovation law in Latin America, it has already earned praise from the country's scientific community, especially from that part dealing with applied research in industry and agriculture, with an emphasis on biotech. ...
    Materialart: Digitale Medien
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  • 38
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 24 (2006), S. 1188-1188 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] When Michael Fernandez took over as director of the Pew Initiative on Food and Biotechnology (PIFB) in September 2005, his former boss bequeathed to him a lava lamp for his desk. Oddly enough, the lamp had been the prize for a Halloween costume that parodied Fernandez' image as a dapper science ...
    Materialart: Digitale Medien
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  • 39
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 24 (2006), S. 1199-1200 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] To the editor: In their letter of correspondence “Eprex-associated pure red cell aplasia and leachates” in the June issue (Nat. Biotechnol. 24, 613–614, 2006), Schellekens & Jiskoot discuss what they consider to be flaws in Johnson & Johnson's (J&J; New Brunswick, NJ, ...
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 40
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 24 (2006), S. 1207-1207 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] When a biotech company succeeds, it can find more cash in the bank than needed for research and development. It may decide to buy back, or repurchase, its own shares. A buyback is neither good nor bad by definition, but may be smart, dumb or bordering on fraudulent. To make you a savvier, more ...
    Materialart: Digitale Medien
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  • 41
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 24 (2006), S. 1474-1475 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] To the editor: Determining the functions of genes and proteins is a central problem in biology, fundamental to understanding the molecular and biochemical processes that sustain health or cause disease, to identifying and validating new drug targets and to developing reliable diagnostics. Recent ...
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 42
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 24 (2006), S. 1223-1224 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] The emergence of systems biology has led to a demand for quantitative, comprehensive data on all aspects of biological phenomena. Some aspects, such as RNA expression and protein structure, have received much attention, while others, such as protein location, have lagged behind. In this issue, ...
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 43
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 24 (2006), S. 1227-1229 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] The shift toward sustainable production systems has focused attention on bioplastics, which can be produced by many microorganisms from renewable raw materials. Polyhydroxyalkanoates (PHAs) are natural polyesters synthesized in the form of discrete intracellular granules in abundances that can ...
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 44
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 24 (2006), S. 1229-1230 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Wastewater treatment around the world relies largely on microbial ecosystems, yet little is known about the organisms involved. This 'black box' system mediates aerobic and anaerobic processes that diminish high phosphate loads in wastewaters, a process known as enhanced biological phosphate ...
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 45
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Standard microarrays measure mRNA abundance, not mRNA synthesis, and therefore cannot identify the mechanisms that regulate gene expression. We have developed a method to overcome this limitation by using the salvage enzyme uracil phosphoribosyltransferase (UPRT) from the protozoan Toxoplasma ...
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 46
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Gluconobacter oxydans is unsurpassed by other organisms in its ability to incompletely oxidize a great variety of carbohydrates, alcohols and related compounds. Furthermore, the organism is used for several biotechnological processes, such as vitamin C production. To further our understanding of ...
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 47
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 253-260 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Parallel functional modules are separate sets of proteins in an organism that catalyze the same or similar biochemical reactions but act on different substrates or use different cofactors. They originate by gene duplication during evolution. Parallel functional modules provide versatility and ...
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 48
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 24 (2006), S. 1033-1033 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Nat. Biotechnol. 24, 841–847 (2006); published online 25 June 2006; corrected after print 25 July 2006 In the print version of this article and the version initially published online, the last sentence of the URLs section in Methods, p.846, reads, “Sequence information regarding the ...
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 49
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Most of the published quantitative models in biology are lost for the community because they are either not made available or they are insufficiently characterized to allow them to be reused. The lack of a standard description format, lack of stringent reviewing and authors' carelessness are the ...
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 50
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Lactobacillus sakei is a psychrotrophic lactic acid bacterium found naturally on fresh meat and fish. This microorganism is widely used in the manufacture of fermented meats and has biotechnological potential in biopreservation and food safety. We have explored the 1,884,661-base-pair (bp) circular ...
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 51
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 1534-1541 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] The potential of human embryonic stem (hES) cells to differentiate into cell types of a variety of organs has generated much excitement over the possible use of hES cells in therapeutic applications. Of great interest are organs derived from definitive endoderm, such as the pancreas. We have ...
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 52
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 1503-1508 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Expression profiling of time-series experiments is widely used to study biological systems. However, determining the quality of the resulting profiles remains a fundamental problem. Because of inadequate sampling rates, the effect of arrest-and-release methods and loss of synchronization, the ...
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 53
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 24 (2006), S. 1033-1033 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Nat. Biotechnol. 23, 995–1001 (2005), published online 17 July 2005; corrected after print 25 July 2006 In the Methods section, p. 1,000, col. 2, paragraph 2, the text beginning: “The whole plate was discarded if for any time point...” and ending, “The final data set ...
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 54
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 24 (2006), S. 1033-1033 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Nat. Biotechnol. 24, 708–712 (2006); published online 21 May 2006; corrected after print 25 July 2006 In the Methods section, p.711, “Library construction and selection,” line 11 of the print version of this article and the version initially published online, the plates used for ...
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 55
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 24 (2006), S. 51-53 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] How does one model a simple cell-signaling pathway? Consider a simple example consisting of a stimulant, an extracellular signal, an inhibitor of the signal, a G protein–coupled receptor, a G protein and the cellular response. The stimulant induces production of the extracellular signal in ...
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 56
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 24 (2006), S. 79-88 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Existing variants of green fluorescent protein (GFP) often misfold when expressed as fusions with other proteins. We have generated a robustly folded version of GFP, called 'superfolder' GFP, that folds well even when fused to poorly folded polypeptides. Compared to 'folding reporter' GFP, a ...
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 57
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 24 (2006), S. 100-104 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Bacterial protein secretion is important in the life cycles of most bacteria, in which it contributes to the formation of pili and flagella and makes available extracellular enzymes to digest polymers for nutritional purposes and toxins to kill host cells in infections of humans, animals and ...
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 58
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 24 (2006), S. 63-71 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] The area devoted to growing transgenic plants expressing insecticidal Cry proteins derived from Bacillus thuringiensis (Bt) is increasing worldwide. A major concern with the adoption of Bt crops is their potential impact on nontarget organisms including biological control organisms. Regulatory ...
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 59
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 24 (2006), S. 874-874 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] The return of the multiple sclerosis (MS) drug Tysabri (natalizumab) to the US market, sanctioned by the US Food and Drug Administration (FDA) on June 5, and its first-time approval in the EU, announced on June 29, was welcomed by investors. The move should also eventually lead to a clearer ...
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 60
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 24 (2006), S. 875-876 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Nuvelo is forging ahead with phase 3 trials on its blood-clot buster enzyme alfimeprase, with results expected early next year. The recombinant enzyme attracted the attention of Bayer Healthcare, which earlier this year signed a $385-million deal for alfimeprase's non-US rights—an ...
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 61
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 1037-1039 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] As the $30 billion monoclonal antibody (mAb) market moves from murine-based to chimeric and fully human products, it grows at a compounded clip of nearly 20% per year (see ). This spectacular growth—Synagis (pavilivizumb; MedImmune, Gaithersburg, Maryland), Herceptin (trastuzumab; ...
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 62
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 1045-1045 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] To the editor: The paper by Kazuya Watanabe and colleagues published in the January issue (Nat. Biotechnol. 23, 88–93, 2005) is framed both in the paper itself and in the accompanying News & Views by Jo Handelsman (Nat. Biotechnol. 23, 38–39, 2005) as an astute, general genetic ...
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 63
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 1045-1046 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Watanabe and colleagues respond: de Lorenzo outlines some possible limitations of the substrate-induced gene expression screening (SIGEX) method. Although we discussed many of the points in his letter in our paper, it is worth reiterating them to emphasize the challenges faced in designing a ...
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 64
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 1046-1046 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] To the editor: Your editorial in the June issue (Nat. Biotechnol. 23, 633, 2005) on the biotech open source movement skirted round one critical difference between biotech and the software industry whose 'open source' movement Richard Jefferson seeks to emulate. Writing software is cheap and can be ...
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 65
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 24 (2006), S. 884-884 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Diagnostics companies have had record fundraising on the public markets over the past few years. Venture capital also expanded last year, raising more than double than in previous years, with $113 million the average quarterly amount raised over the past year compared with only $47 ...
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 66
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 24 (2006), S. 885-887 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Even as the science supporting innovation in drug and device development moves forward, the US agency charged with evaluating the products of that science remains embroiled in battles over resources and even its proper mandate. Indeed, the Food and Drug Administration (FDA, Rockville, MD, USA), ...
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 67
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 24 (2006), S. 888-890 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Once the province of clinical genetics units in hospitals and clinics, genetic tests have become a commodity. With the click of a mouse, you can order up tests to find out whether you are a carrier of the cystic fibrosis (CF) gene, prone to cardiovascular disease or a member of an ancient tribe. ...
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 68
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 24 (2006), S. 1226-1227 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Mass spectrometry (MS) allows the localization of phosphorylated amino acid residues in proteins. Precise annotation of phosphorylation sites is not trivial, however, because of the inherent complexity of most phosphopeptide mass spectra. In this issue, Beausoleil et al. report computational ...
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 69
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 24 (2006), S. 899-899 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] To the editor: In their commentary in the December issue (Nat. Biotechnol. 23, 1479–1480, 2005) Jon Beckwith and Franklin Huang chastise T. H. Morgan for his failure to make a fuss about eugenics in 1915. That year, he gave the Vanuxem Lectures at Princeton University, which were published ...
    Materialart: Digitale Medien
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  • 70
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 24 (2006), S. 899-900 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] To the editor: An endorsement of ethical responsibility in science is difficult to oppose. The challenge, however, often is to ascertain what constitutes an ethical or wise course of action. In their commentary, Beckwith and Huang allude specifically to a “stirring of the scientific ...
    Materialart: Digitale Medien
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  • 71
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 24 (2006), S. 900-901 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] To the editor: The letter by Katariina Majander et al. in last year's April issue (Nat. Biotechnol. 23, 475–481, 2005) described the use of a modified flagellar type III secretion system (TTSS) to secrete heterologous polypeptides into the growth medium of Escherichia coli. N-terminal ...
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 72
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 24 (2006), S. 901-902 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Katariina Majander et al. respond In contrast to the comments of Gál et al., the aim of our paper was not to address the nature of the secretion signal motif per se but to evaluate the biotechnological potential of the secretion system. We did, however, briefly discuss the three proposed ...
    Materialart: Digitale Medien
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  • 73
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 24 (2006), S. 914-916 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Chromogenic stains have been a mainstay as readouts for immunodiagnostics. 'Brown' staining—also known as diaminobenzidine (DAB) chromogenic staining or immunoperoxidase staining—was adopted very early in anatomic pathology and rapidly became the standard for immunohistochemistry in ...
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 74
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 24 (2006), S. 902-903 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] To the editor: PubMed is the key retrieval engine for Medline abstracts, and its host, the US National Library of Medicine (NLM; Bethesda, Maryland), provides efficient query interfaces. The result of queries is a list of abstracts, in which the most recent documents appear at the top. If the list ...
    Materialart: Digitale Medien
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  • 75
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 24 (2006), S. 905-908 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Biomarkers measured in a variety of patient samples, including blood, tissue, urine and cerebrospinal fluid, are used in a diverse array of clinical settings. Although many successful biomarkers have been developed to date, advances in genetics and proteomics promise to usher in a new era of ...
    Materialart: Digitale Medien
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  • 76
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 1019-1019 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Nanotech-based sequencing Roche and 454 Life Sciences, a subsidiary of CuraGen, offer a nanotechnology-based genome sequencing system that allows a single instrument to produce over 20 million nucleotide bases per 4-hour run, totaling more than 100 times the capacity of instruments using current ...
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 77
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 903-903 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] BiDil is a recently approved therapy indicated for congestive heart failure patients already taking standard treatments. It is not a new drug. It is a combination of two existing drugs—isosorbide dinitrate and hydralazine—already marketed seperately as generics. What is new about BiDil ...
    Materialart: Digitale Medien
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  • 78
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 907-907 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] The Tokyo-based pharmaceutical development firm GNI announced its merger with Shanghai Genomics on June 20, marking the first such partnership between a Japanese and a Chinese biotech in over a decade. The newly formed venture has a research staff of more than 80 in Japan, China and England, and a ...
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 79
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 913-913 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] During the 13 years that he was CEO of Human Genome Sciences (HGS), William Haseltine rarely traveled for pleasure. He was even less mobile before his tenure at the Rockville, Maryland–based genomics firm that he founded in 1992; as a cancer and AIDS researcher at the Dana Farber Cancer ...
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 80
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 914-914 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Although private financing and overall funding remain relatively stable, investor interest in biotech is a shadow of a year ago, when the initial public offering (IPO) market had just come off the best two quarters of this window. The BioCentury 100 Index has fallen by a little more than 10%, and ...
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 81
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 24 (2006), S. 927-929 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] In vitro diagnostics (IVDs) has been an area of considerable innovation over the past decade, transforming the practice of medicine in the process. In the area of cardiovascular care alone, new markers for early cardiac injury and for heart failure have fundamentally changed the way doctors manage ...
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 82
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 24 (2006), S. 930-930 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Although you might have been led to believe there is a 'clear vision' for the molecular diagnostics revolution, in reality the investing picture is much murkier. Revenues haven't produced much profit or free cash flow (and are unlikely to do so anytime soon). And rather than stand-alone diagnostics ...
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 83
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 24 (2006), S. 45-46 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Fish have been used as models in cancer research for almost a century because of the strikingly similar histopathological features of fish and human tumors. Despite this agreement, however, very little is known about the correspondence of the molecular mechanisms that drive tumorigenesis in these ...
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 84
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 946-947 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] In just a few years, small interfering RNA (siRNA) has emerged as a powerful technology to specifically knockdown genes in mammalian cells both for functional analysis and for therapeutic purposes. The success of this approach, also called RNA interference (RNAi), hinges on the affinity of an siRNA ...
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 85
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] A catalog of all human protein-protein interactions would provide scientists with a framework to study protein deregulation in complex diseases such as cancer. Here we demonstrate that a probabilistic analysis integrating model organism interactome data, protein domain data, genome-wide gene ...
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 86
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 1325-1325 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] In September, Lester Crawford resigned as commissioner of the US Food and Drug Administration (FDA), leaving a leadership vacuum that was quickly filled by President Bush's appointment of Andrew von Eschenbach, formerly the director of the National Cancer Institute (NCI), as acting commissioner. ...
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 87
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 1327-1328 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Officials at Sandoz, the generic branch of Novartis of Basel, filed a rare type of lawsuit with the US District Court on September 13. The company wants the court to force the US Food and Drug Administration (FDA) to rule on—preferably, approve—Omnitrope, its follow-on version of ...
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 88
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 1329-1330 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Cabilly patent invalidated Genentech's stronghold on monoclonal antibody production techniques may slip if a recent US Patent and Trademark Office's (USPTO) initial ruling is upheld. In late September, the USPTO rejected the company's ubiquitous Cabilly 2 patent on the grounds that it extends the ...
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 89
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 1332-1332 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] In a risk-averse market, biotech stock market indices showed sluggish growth, being outperformed by broader market indicators. Venture capital funding remained relatively stable but public biotechs were able to take advantage of debt, private investment in public equitities (PIPEs) and follow-on ...
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 90
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 1331-1331 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Is Chicago artist-writer-philosopher Eduardo Kac ahead of his time or just nuts? In the foreword of his new book, Art Institute of Chicago art historian James Elkins makes the case for the former. Elkins acknowledges, however, that not everybody agrees on this point and cites the negative critiques ...
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 91
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 1333-1335 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] The Human Genome Project cost nearly $3 billion, and no one would quibble with the price tag. The scientific benefit is incalculable. But translating the potential of genomics into tangible benefits for basic and biomedical research, not to mention personalized medicine, will require vast ...
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 92
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 1343-1343 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] To the editor: We were greatly disturbed to read your editorial in the August issue (Nat. Biotechnol. 23, 903, 2005) which made disparaging comments about BiDil, a new heart failure medication for blacks that has been shown clearly to be safe and effective. Despite misleading claims in your ...
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 93
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 1343-1344 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Nature Biotechnology responds to BiDil's impact: In citing their three 'crucial' facts, Puckrein and Yang sidestep the main point of our editorial: BiDil is a poor example of targeted medicine. As far as we know, skin pigmentation has not yet been genetically linked to (less still shown to be an ...
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 94
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 801-804 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] With relatively little fanfare, the current Good Tissue Practices (cGTP) Final Rule finally came into force in the United States in May. Under its legal authority, the US Food and Drug Administration (FDA) now inspects entities involved in the manufacture of human cells, tissues, and cellular and ...
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 95
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 1345-1345 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Lok and Brent respond: Our simulation program, Moleculizer, calculates cellular reaction networks by allowing protein complexes to form in silico. From the correspondence of Hlavacek and colleagues, we take two main points. They argue that there are advantages to generating reaction networks ...
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 96
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 1085-1087 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] In a stroke of serendipity, researchers investigating plant responses to the explosive TNT have stumbled upon a transporter gene that may obviate the need for bacterial selectable markers in the generation of transgenic plants. As described in this issue, Mentewab and Stewart were studying the ...
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 97
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 1346-1348 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Fabian et al. respond: Buolamwini and Kamath suggest that the data presented in our manuscript lack statistical validation and are not sufficiently quantitative to justify some of our conclusions. In particular, they state that the validation of our technology, which included a detailed comparison ...
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 98
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 1348-1349 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] To the editor: Monitoring the evolution of plant transgenic science is hampered by the difficulty of obtaining accurate bibliometric information compared with equivalent animal and microbial research. This is mostly due to the imprecision of the term 'transformation,' which is generally used to ...
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 99
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 1353-1355 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Tissue engineering is having difficulty transitioning from a development-stage industry to one with a successful product portfolio. Currently, many of the key international tissue-engineering centers focus almost exclusively on the biology of tissue culture to the detriment of manufacturing and ...
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 100
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 1357-1357 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] In Liberation Biology, Ronald Bailey grapples with many of the key ethical issues raised by our advances in biotech. He seeks to counterbalance the bleak vision of the future, akin to Huxley's Brave New World, predicted by Leon Kass, Francis Fukuyama and other 'bioconservatives.' Bailey's own ...
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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