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  • 05. General::05.09. Miscellaneous::05.09.99. General or miscellaneous  (3)
  • Xenopus laevis  (3)
  • Elsevier  (6)
  • Public Library of Science (PLoS)
  • 2015-2019  (6)
  • 1
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    Geosciences and the stewardship of our planet (2015)
    Elsevier
    Details
    Publication Date: 2020-02-24
    Description: The time for a first book on Geoethics has come. The faster, greedier pace of society and globalization demands it. The comfortable life of scholars in the ivory tower is coming to a rude awakening. People demand understandable information on geohazards, judges condemn scientist and engineers for lack of communication, indigenous people rise in anger accusing experts of misleading them, attempts to avoid transparency in developments still exist, the helplessness of technology to deal with nuclear waste becomes more evident everyday and nature exposes shortcuts in constructing critical facilities with her own awesome force.....
    Description: Published
    Description: XXI-XXII
    Description: 3T. Pericolosità sismica e contributo alla definizione del rischio
    Description: 4V. Vulcani e ambiente
    Description: 4A. Clima e Oceani
    Description: 5A. Energia e georisorse
    Description: 6A. Monitoraggio ambientale, sicurezza e territorio
    Description: reserved
    Keywords: Geoethics ; Philosophy ; Geosciences ; Geoscientists ; Ethics ; Earth Sciences ; Sustainability ; Research Integrity ; Professional Ethics ; Geoscience communication ; Responsibility ; Stewardship ; Planet ; Earth ; 05. General::05.03. Educational, History of Science, Public Issues::05.03.99. General or miscellaneous ; 05. General::05.08. Risk::05.08.99. General or miscellaneous ; 05. General::05.09. Miscellaneous::05.09.99. General or miscellaneous
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: book chapter
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  • 2
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    Geoethics: ethical challenges and case studies in Earth Science (2015)
    Elsevier
    Details
    Publication Date: 2017-04-04
    Description: Key Features. Written by a global group of contributors with backgrounds ranging from philosopher to geo-practitioner, providing a balance of voices. Includes case studies, showing where experts have gone wrong and where key organizations have ignored facts, wanting assessments favorable to their agendas. Provides a much needed basis for discussion to guide scientists to consider their responsibilities and to improve communication with the public. Description. Edited by two experts in the area, Geoethics: Ethical Challenges and Case Studies in Earth Sciences addresses a range of topics surrounding the concept of ethics in geoscience, making it an important reference for any Earth scientist with a growing concern for sustainable development and social responsibility. This book will provide the reader with some obvious and some hidden information you need for understanding where experts have not served the public, what more could have been done to reach and serve the public and the ethical issues surrounding the Earth Sciences, from a global perspective. Table of contents. Section 1: Introduction Section 2: Philosophical reflections Section 3: The ethics of practice Section 4: Man made hazards Section 5: Natural hazards Section 6: Exploitation of resources Section 7: Low income and indigenous communities Section 8: Geoscience community
    Description: Published
    Description: 3T. Pericolosità sismica e contributo alla definizione del rischio
    Description: 5T. Sorveglianza sismica e operatività post-terremoto
    Description: 4V. Vulcani e ambiente
    Description: 5V. Sorveglianza vulcanica ed emergenze
    Description: 4A. Clima e Oceani
    Description: 6A. Monitoraggio ambientale, sicurezza e territorio
    Description: open
    Keywords: Geoethics ; Philosophy ; Natural hazards ; Man made hazards ; Georesources ; Low income countries ; Geoscience community ; Communication ; Geoeducation ; Natural risks ; 04. Solid Earth::04.06. Seismology::04.06.11. Seismic risk ; 04. Solid Earth::04.08. Volcanology::04.08.08. Volcanic risk ; 05. General::05.03. Educational, History of Science, Public Issues::05.03.99. General or miscellaneous ; 05. General::05.08. Risk::05.08.99. General or miscellaneous ; 05. General::05.09. Miscellaneous::05.09.99. General or miscellaneous
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: book
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  • 3
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    The Meaning of Geoethics (2015)
    Elsevier
    Details
    Publication Date: 2017-04-04
    Description: This chapter outlines a framework of the issues addressed by geoethics. Starting from an etymological analysis of the word “geoethics,” we identify the cultural basis on which to expand the debate on geoethics, while also proposing for consideration by the scientific community some questions that may guide the development of future research and practice in geosciences. We attempt to define some fundamental points that, in our opinion, will strengthen geoethics and help its development. The goal of geoethics is to suggest practical solutions and provide useful techniques, and also to promote cultural renewal in how humans perceive and relate to the planet, through greater attention to the protection of life and the richness of the Earth, in all its forms. As each science does, geoethics should also be able to present an image of the world, pointing out the manner in which it can be understood, investigated, designed, and experienced.
    Description: Published
    Description: 3-14
    Description: 3T. Pericolosità sismica e contributo alla definizione del rischio
    Description: 4V. Vulcani e ambiente
    Description: 4A. Clima e Oceani
    Description: 5A. Energia e georisorse
    Description: 6A. Monitoraggio ambientale, sicurezza e territorio
    Description: reserved
    Keywords: Etymological analysis ; Geoethics ; Geoscientists oath ; Responsibility ; Society ; 05. General::05.03. Educational, History of Science, Public Issues::05.03.99. General or miscellaneous ; 05. General::05.09. Miscellaneous::05.09.99. General or miscellaneous
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: book chapter
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  • 4
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    Generation of a Xenopus laevis F1 albino J strain by genome editing and oocyte host-transfer (2017)
    Elsevier
    Details
    Publication Date: 2022-05-25
    Description: © The Author(s), 2016. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Developmental Biology 426 (2017): 188–193, doi:10.1016/j.ydbio.2016.03.006.
    Description: Completion of the Xenopus laevis genome sequence from inbred J strain animals has facilitated the generation of germline mutant X. laevis using targeted genome editing. In the last few years, numerous reports have demonstrated that TALENs are able to induce mutations in F0 Xenopus embryos, but none has demonstrated germline transmission of such mutations in X. laevis. In this report we used the oocyte host-transfer method to generate mutations in both tyrosinase homeologs and found highly-penetrant germline mutations; in contrast, embryonic injections yielded few germline mutations. We also compared the distribution of mutations in several F0 somatic tissues and germ cells and found that the majority of mutations in each tissue were different. These results establish that X. laevis J strain animals are very useful for generating germline mutations and that the oocyte host-transfer method is an efficient technique for generating mutations in both homeologs.
    Description: This work was supported by grants from the NIH (OD010997 and HD084409).
    Keywords: Xenopus laevis ; TALENs ; J strain ; Tyrosinase ; Oocyte host-transfer ; Genome editing
    Repository Name: Woods Hole Open Access Server
    Type: Article
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  • 5
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    Luteinizing Hormone is an effective replacement for hCG to induce ovulation in Xenopus (2017)
    Elsevier
    Details
    Publication Date: 2022-05-25
    Description: © The Author(s), 2016. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Developmental Biology 426 (2017): 442–448, doi:10.1016/j.ydbio.2016.05.028.
    Description: Injection of human Chorionic Gonadotropin (hCG) directly into the dorsal lymph sac of Xenopus is a commonly used protocol for induction of ovulation, but recent shortages in the stocks of commercially available hCG as well as lack of a well tested alternative have resulted in frustrating experimental delays in laboratories that predominantly use Xenopus in their research. Mammalian Luteinizing Hormones (LH) share structural similarity, functional equivalency, and bind the same receptor as hCG; this suggests that LH may serve as a good alternative to hCG for promoting ovulation in Xenopus. LH has been found to induce maturation of Xenopus oocytes in vitro, but whether it can be used to induce ovulation in vivo has not been examined. Here we compared the ability of four mammalian LH proteins, bovine (bLH), human (hLH), ovine (oLH), porcine (pLH), to induce ovulation in Xenopus when injected into the dorsal lymph sac of sexually mature females. We find that both ovine and human LH, but not bovine or porcine, are good substitutes for hCG for induction of ovulation in WT and J strain Xenopus laevis and Xenopus tropicalis.
    Description: This work was supported by a grant from the NIHP40OD010997.
    Keywords: Xenopus laevis ; J strain ; Luteinizing Hormone ; Ovulation ; Chorionic gonadotropin
    Repository Name: Woods Hole Open Access Server
    Type: Article
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  • 6
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    Expanding the genetic toolkit in Xenopus : approaches and opportunities for human disease modeling (2017)
    Elsevier
    Details
    Publication Date: 2022-05-25
    Description: © The Author(s), 2016. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Developmental Biology 426 (2017): 325-335, doi:10.1016/j.ydbio.2016.04.009.
    Description: The amphibian model Xenopus, has been used extensively over the past century to study multiple aspects of cell and developmental biology. Xenopus offers advantages of a non-mammalian system, including high fecundity, external development, and simple housing requirements, with additional advantages of large embryos, highly conserved developmental processes, and close evolutionary relationship to higher vertebrates. There are two main species of Xenopus used in biomedical research, Xenopus laevis and Xenopus tropicalis; the common perception is that both species are excellent models for embryological and cell biological studies, but only Xenopus tropicalis is useful as a genetic model. The recent completion of the Xenopus laevis genome sequence combined with implementation of genome editing tools, such as TALENs (transcription activator-like effector nucleases) and CRISPR-Cas (clustered regularly interspaced short palindromic repeats-CRISPR associated nucleases), greatly facilitates the use of both Xenopus laevis and Xenopus tropicalis for understanding gene function in development and disease. In this paper, we review recent advances made in Xenopus laevis and Xenopus tropicalis with TALENs and CRISPR-Cas and discuss the various approaches that have been used to generate knockout and knock-in animals in both species. These advances show that both Xenopus species are useful for genetic approaches and in particular counters the notion that Xenopus laevis is not amenable to genetic manipulations.
    Description: This work was supported by the National Institutes of Health (P40 OD010997 to M.E.H., R01 HD084409 to M.E.H., R01 HL112618 to P.T. and F.C., and R01 HL127640 to P.T. and F.C.; and the U.S. Environmental Protection Agency (G11E10367 to D.F.).
    Keywords: CRISPR-Cas ; TALENs ; J strain ; Xenopus laevis ; Xenopus tropicalis ; Knock-in ; Human disease model
    Repository Name: Woods Hole Open Access Server
    Type: Article
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