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  • thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics  (133)
  • thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology  (101)
  • Chemistry
  • Life and Medical Sciences
  • IntechOpen  (255)
  • 2020-2024  (255)
  • 1950-1954
  • 1945-1949
Collection
Keywords
Publisher
Language
Years
  • 2020-2024  (255)
  • 1950-1954
  • 1945-1949
Year
  • 1
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    Epilepsy During the Lifespan (2024)
    IntechOpen | IntechOpen
    Details
    Publication Date: 2024-04-01
    Description: Epilepsy During the Lifespan - Beyond the Diagnosis and New Perspectives discusses the most widespread neurological pathology in the world. The book presents interesting contributions to controversial topics in epilepsy. It includes nine chapters organized into three sections: “New and Old Perspectives on Epilepsy”, “Epileptic Syndromes” and “Society and Epilepsy”.
    Keywords: thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology
    Language: English
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  • 2
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    Potential Therapeutic Strategies for Muscular Dystrophy (2024)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-01
    Description: The book provides a comprehensive overview of the different forms of muscular dystrophy (MD), including potential therapeutic interventions and the advantages associated with repurposing pharmaceuticals for treating these conditions. In addition, the book examines the effects of physical training on improving symptoms as well as patient quality of life and life span. The target audience of this book comprises students, researchers, and doctors with an interest in the field of muscular dystrophy.
    Keywords: muscle strength ; stem cells ; cell therapy ; physiotherapy ; astrocyte ; cell proliferation ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology
    Language: English
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  • 3
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    Ataxia (2024)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-01
    Description: This book presents a comprehensive overview of ataxia, a common neurological disorder that affects all ages. It can manifest in children when they start to sit and walk and under a specific form of genetic disease and in the elderly through falls that worsen with age. In general, ataxia consists of the involuntary lack of coordination of muscle movements, which mainly presents as abnormalities in gait, changes in speech (e. g., scanning speech), and abnormal eye movements such as nystagmus. It results from dysfunction of the nervous system areas responsible for the coordination of movements and, most commonly, the cerebellum and its connections to the cerebrum and periphery. The book is organized into three sections and six chapters that address such topics as genetic conditions, childhood-onset ataxia, ataxia and multiple sclerosis, therapeutic interventions, and more.
    Keywords: thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology
    Language: English
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  • 4
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    Stroke (2024)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-01
    Description: Adequate stroke care access not only requires the availability of comprehensive healthcare facilities but also needs affordability and knowledge of the availability of these services. Presentations of stroke syndromes depend on their location, size, and underlying comorbidities. These lesions can have clinical features of increased intracranial pressure, focal neurological deficits, or seizures (generalized or partial) with rapid progression. This book presents high-quality research work on recent advances in the management of stroke.
    Keywords: rehabilitation ; eeg ; endothelial dysfunction ; headache ; spasticity ; neurofeedback ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology
    Language: English
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  • 5
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    Epigenetics (2024)
    IntechOpen | IntechOpen
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    Publication Date: 2024-03-31
    Description: Epigenetics plays a crucial role in regulating gene expression, particularly in the field of transcriptomics. Dysfunctions in epigenetics have been identified as key factors in the development of cancer and numerous complex diseases. This book presents the most recent advancements in epigenetics omics technologies and their utilization in understanding the mechanisms of cancer and complex diseases. We hope that this book will serve as an enlightening resource, broadening the horizons of our readers and motivating them to explore the potential of integrating multi-omics data for investigating epigenetic regulations in different biomedical scenarios.
    Keywords: oxidative stress ; dna methylation ; cancer ; biomarkers ; aging ; microrna ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
    Language: English
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  • 6
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    Advances in Genetic Polymorphisms (2024)
    IntechOpen | IntechOpen
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    Publication Date: 2024-03-31
    Description: The field of single nucleotide polymorphisms (SNPs) analysis has undergone impressive advancement, mainly due to the advent of modern high-throughput genotyping technologies and the emergence of innovative algorithms and computational methods, leading to exciting applications in human health. This book presents fundamental and recent aspects of SNP analysis techniques and applications in the new era of precision medicine. It includes six chapters that discuss a panoply of advanced aspects related to the clinical relevance of SNP analysis in diagnostic, prognostic, and predictive values in human health.
    Keywords: SNP ; Mutations ; Genetic Tools ; PCR ; Susceptibility ; Human Diseases ; Prognosis ; Diagnosis ; Association ; Populations ; Precision Medicine ; Pharmacogenomics ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
    Language: English
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  • 7
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    Frontiers in Hydrocephalus (2024)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-01
    Description: This book represents the collective expertise and dedication of numerous scholars and professionals from around the globe who share a keen interest in hydrocephalus. As a specialized text, it delves into the most advanced concepts and technological developments in the diagnosis and treatment of hydrocephalus. This book offers an extensive introduction to the history of hydrocephalus treatment, the current state of therapeutic approaches, diverse treatment methods, common complications associated with hydrocephalus, and the diagnosis and treatment of several rare forms of the condition. While the book consolidates traditional viewpoints, it places even greater emphasis on presenting the most recent diagnostic and treatment concepts in hydrocephalus. The innovative inductive summaries of certain rare or unique types of hydrocephalus are particularly noteworthy. This comprehensive approach allows readers to gain a more profound and well-rounded understanding of the evolution and future trajectory of hydrocephalus. Catering to a diverse audience, this book is not only appropriate for junior neurosurgeons seeking a foundational understanding of hydrocephalus but also serves to satisfy the more in-depth inquiries of experienced senior neurosurgeons exploring the subject matter.
    Keywords: tuberculosis ; biomechanics ; ascites ; meningitis ; intracranial pressure ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology
    Language: English
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  • 8
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    Parkinson’s Disease (2024)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-01
    Description: Despite being described about 200 years ago, the pathophysiology of Parkinson’s disease (PD) is not well understood due to its complex etiology and heterogeneity of symptoms and progression. Animal models provide a great opportunity to follow the progression of neurodegeneration and to screen potent therapeutic molecules, knowledge of which can be critical for different levels of clinical trials. Contemporary health technologies are coming in handy to accelerate the pace of developing novel and refined therapeutic strategies for PD. This book, Parkinson’s Disease - Animal Models, Current Therapies and Clinical Trials, provides a comprehensive overview of PD, presenting information on animal models of PD and contemporary therapeutic strategies, health technologies, clinical trials, and their influence on the quality of life of patients with PD.
    Keywords: thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology
    Language: English
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  • 9
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    Multiple Sclerosis (2024)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-01
    Description: Multiple sclerosis (MS) is a lifelong neurological condition that has no known cure. This book provides an extensive exploration of current and future directions for understanding immunology, neuroscience, and the development of potent treatment modalities. It presents an in-depth analysis and expert commentary on the role of genetics, lifestyle factors, biomarkers, neuroimaging, cognitive domains, artificial intelligence, and innate immunity in MS pathogenesis. We hope that the book is helpful to readers of all spheres of life, including those who want to understand more about MS, those who are keen to improve their understanding of MS disease pathogenesis, those who are enthusiastic to know more about treatment modalities, and those who want to be informed about state-of-the-art clinical developments in MS.
    Keywords: thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology
    Language: English
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  • 10
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    Advances in Cerebral Aneurysm Treatment (2024)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-01
    Description: As diagnostic and functional neuroimaging advances, the choice of the best patient-tailored treatment for cerebral aneurysm becomes far more difficult. New technologies that can help identify the most suitable therapy include machine learning algorithms to process big data, robotic applications for interventional procedures, and dynamic vascular flow models. Different biological and epidemiological parameters have been delineated as prognostic factors that add a fundamental piece of information to the decision of whether to proceed with surgery, endovascular treatment, or a combination of both. With technical improvement and prolonged patient life expectancy, recurrent cerebral aneurysm is becoming more common. To deal with the complex issue of aneurysm re-intervention, a clear definition of the clinical and radiological outcomes is essential. This book provides a comprehensive overview of the currently emerging innovations in the treatment of cerebral aneurysms, from their pre-operative holistic assessment to long-term follow-up, focusing on the opportunities provided by the newest technologies.
    Keywords: machine learning ; artificial intelligence ; neuroinflammation ; neurosurgery ; ischemic stroke ; subarachnoid hemorrhage ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology
    Language: English
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  • 11
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    Cerebral and Cerebellar Cortex (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-01
    Description: Cerebral and Cerebellar Cortex – Interaction and Dynamics in Health and Disease discusses several important issues of cerebro-cerebellar collaboration and interactions. The morphological and functional study of the cerebral and cerebellar cortices and their interaction has considerable value for interpreting the clinical phenomenology of cortical degenerations in the initial stage of the disease. In addition, the analysis of cerebro-cerebellar interactions strongly supports the concept of the close functional unity and harmonization of the brain and the cerebellum, underlining the important role that the cerebellar cortex plays in the performance of higher mental faculties, creativity, emotional processes, and homeostatic equilibrium of the human body.
    Keywords: alzheimer’s disease, mitochondria, stroke, neurodegeneration, neuroplasticity, cerebellum ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology
    Language: English
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  • 12
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    Mineralogy (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-05
    Description: Mineralogy includes thirteen chapters that discuss the methodology of specific mineralogical methods, the composition of minerals from different igneous rocks, and the composition of minerals from different sedimentary rocks.It contains detailed mineralogical studies from Africa, Asia, and Europe. Chapters present different scientific mineralogical methods and detailed descriptions of minerals from different magmatic and sedimentary rocks.
    Keywords: Chemistry ; thema EDItEUR::P Mathematics and Science::PN Chemistry::PNV Chemistry of minerals, crystals and gems
    Language: English
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  • 13
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    Benzimidazole (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-05
    Description: Benzimidazole is a comprehensive survey of the known and new methods of benzimidazole synthesis, the spectral and theoretical aspects of existing benzimidazole derivatives, and the anticancer properties of a new class of benzimidazole derivatives. This book examines aspects and newer mechanisms of benzimidazoles containing heterocyclic moiety. Chapters report on anticancer properties of benzimidazole derivatives, novel methods of synthesis of benzimidazoles, versatile nature of the benzimidazoles, spectral and theoretical studies of benzimidazole derivatives, and medicinal importance and pharmacological aspects of benzimidazole derivatives.
    Keywords: Chemistry ; thema EDItEUR::P Mathematics and Science::PN Chemistry::PNN Organic chemistry
    Language: English
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  • 14
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    Genetic Polymorphisms (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-03-31
    Description: The objective of this Genetic Polymorphisms book is to rehighlight and provide few updates on the role of genetic polymorphisms in medicine and agriculture, which void emerging opinion on "full death" of genetic polymorphisms as useful genetic markers. Chapters presented here demonstrate the future benefit of SNPs in many genetic studies as well as prognosis disease and diagnosis.
    Keywords: atherosclerosis, cancer, hepatocellular carcinoma, colorectal cancer, multiple sclerosis, microrna ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
    Language: English
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  • 15
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    Green Chemistry (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-05
    Description: Green Chemistry - New Perspectives is at the frontiers of this continuously evolving interdisciplinary science, and publishes research that attempts to reduce the environmental impact of the chemical enterprise by developing a technology base that is inherently non-toxic to living things and the environment. The book covers all aspects of green chemistry, including chemical synthesis, nano synthesis, eco-friendly processes, biomass, extraction techniques, environmental remediation, and energy, making it a unique reference resource. This will continue to encourage scientists around the world to develop novel synthetic methods or improve the existing ones to circumvent some of the problems and favours all aspects of green chemistry. This book is intended for academia, professionals, scientists, as well as graduate and undergraduate students without any geographical limitations.
    Keywords: Chemistry ; thema EDItEUR::P Mathematics and Science::PN Chemistry::PNN Organic chemistry
    Language: English
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  • 16
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    Paraplegia (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-01
    Description: In the last decade, diverse research areas have developed novel approaches to overcome dysfunctions after a spinal cord injury (SCI). Even though motor restoration attracts the most clinical attention, sensory, autonomic, and mental health are also aspects fundamental to improving the quality of life of SCI patients. Over four sections of therapeutic, rehabilitation, and technological approaches, this book examines preclinical and clinical studies using mesenchymal stem cells and pharmacological or electrical stimulation strategies. Chapters also address the impact of paraplegia and associated loss of autonomic functions, including bowel and sexual dysfunction, as well as the convergence of new technologies aimed at providing postural support and enhancing mobility.
    Keywords: rehabilitation, stem cell therapy, spinal cord injury, exoskeleton, biomaterials, gut microbiota ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology
    Language: English
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  • 17
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    Update on Amyotrophic Lateral Sclerosis (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-01
    Description: This book contains selected peer-reviewed chapters which cover updated information on ALS written by international researchers. Update on Amyotrophic Lateral Sclerosis is comprised of 13 chapters from some of the world's top central nervous system researchers and neurologists to provide a timely review of the most recent developments in ALS, covering historic aspects, experimental animal models, genetics, pathogenesis, clinical aspects and imagenology among others. Contributors from Belgium, France, Japan, India, Italy, Mexico, Russia, South Africa, and Switzerland have collaborated enthusiastically and efficiently, dedicating their time to create this reader-friendly yet comprehensive work which includes many explanatory figures, tables and photos to enhance legibility and make the book clinically useful. We are looking forward with confidence and pride in the remarkable role that this book will play for a new vision and mission.
    Keywords: als, amyotrophic lateral sclerosis (als), oxidative stress, biomarkers, alzheimer’s disease, neurodegeneration ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology
    Language: English
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  • 18
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    Frontiers In Traumatic Brain Injury (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-01
    Description: Traumatic brain injury (TBI) has the highest incidence of all common neurological dysfunctions and is a risk factor for a variety of neurological diseases. TBI is a major public health burden and the care of TBI patients is difficult. This book provides a comprehensive overview of TBI, addressing progress and needs in research as well as challenges in treatment. Chapters address such topics as emergency room airway management in TBI, craniocerebral injury in pediatric patients, traumatic optic neuropathy, and more.
    Keywords: Clinical & internal medicine ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology
    Language: English
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  • 19
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    Epileptology (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-01
    Description: Epilepsy seems to represent one of the most frequent neurological diseases and occurs in about 1% of the general population. Although epilepsy is known since antiquity, the precise data on its pathogenesis and effective treatment are still collected and nowadays represents an interest for neurologists and psychiatrists. Being a neurological disease, epilepsy is characterized by a broad palette of comorbid psychiatric disorders (affective and anxiety disorders, psychoses) that reduce the quality of life. Moreover, the risk of suicidal attempts in persons with epilepsy is much higher than in general population that once again increases the actuality of epilepsy research in many aspects. The book contains 13 chapters written by different authors from all over the world on different topics, including phenomenology, pathogenesis, and treatment in epilepsy. The modern data on these topics may be helpful for many specialists in the domain of epileptology.
    Keywords: epilepsy, antiepileptic drugs, clinical manifestations, epidemiology, toxicity, genetics ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology
    Language: English
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  • 20
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    Alzheimer's Disease (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-01
    Description: This Edited Volume Alzheimer’s Disease is a collection of reviewed and relevant research chapters, offering a comprehensive overview of recent developments in the field. The book comprises single chapters authored by various researchers and edited by an expert in the field, working on Alzheimer’s disease and dementia with cutting-edge technology. All chapters are complete in themselves but united under a common research study topic. This publication aims at providing a thorough overview of the latest research efforts by international authors in this research area, and opening new possible research paths for further novel developments.
    Keywords: Clinical & internal medicine ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology
    Language: English
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  • 21
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    Gene Expression and Regulation in Mammalian Cells (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-03-31
    Description: Sixty years after the "central dogma," great achievements have been developed in molecular biology. We have also learned the important functions of noncoding RNAs and epigenetic regulations. More importantly, whole genome sequencing and transcriptome analyses enabled us to diagnose specific diseases. This book is not only intended for students and researchers working in laboratory but also physicians and pharmacists. This volume consists of 14 chapters, divided into 4 parts. Each chapter is written by experts investigating biological stresses, epigenetic regulation, and functions of transcription factors in human diseases. All articles presented in this volume by excellent investigators provide new insights into the studies in transcriptional control in mammalian cells and will inspire us to develop or establish novel therapeutics against human diseases.
    Keywords: cancer, dna methylation, inflammation, breast cancer, apoptosis, aging ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
    Language: English
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  • 22
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    Analytical Liquid Chromatography (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-05
    Description: This book consists of several selected chapters on important subjects in modern high-performance liquid chromatography (HPLC) and ultra-performance liquid chromatography (UPLC). The content addresses aspects related to both improvements in the mainstream HPLC/UPLC technology and utilization, as well as developments of exploratory new materials and equipment. The book presents useful details about the presented subjects as well as describes new applications and/or relevant case studies for each subject. It is addressed to a large audience of analytical chemists involved in separation science. Each chapter is authored by scientists with considerable field and academic experience.
    Keywords: Chemistry ; thema EDItEUR::P Mathematics and Science::PN Chemistry::PNF Analytical chemistry
    Language: English
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  • 23
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    Progress in Understanding Cystic Fibrosis (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-03-31
    Description: Congenital defects in humans are of greater concern, and in that line, cystic fibrosis (CF) has been one of the most complex diseases posing treatment challenge till date. Though it is a chronic condition, CF is closely associated with dysfunction of various organ systems of the human body, which in turn results in secondary infections by microbes. Decades of research by scientists worldwide has narrowed down the cause of CF to a single target gene. But the complexity of the disease is the prime impediment to finding a single-shot cure. Fortunately, the multidisciplinary approach toward understanding and management of the CF condition has certainly increased the level of life expectancy among CF patients. In particular, the "omics" and the "systems biology" approach have greatly widened the focal area for better understanding of the disease. This book includes a collection of interesting chapters contributed by eminent scientists around the world who have been striving to improve the life of those affected by CF.
    Keywords: biofilm, pseudomonas aeruginosa, inflammation, wound healing, microbiome, insulin ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
    Language: English
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    Gene Expression (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-03-31
    Description: Gene expression is dependent on multiple steps, including transcription, RNA processing, and translation. Importantly, recent studies revealed that gene expression is regulated by chromatin structures and non-coding RNA profiles. Elucidating the molecular mechanisms may contribute to the development of novel therapeutics for aging-related diseases, including cancer and neurodegenerative diseases. This book provides a comprehensive overview of gene expression and its role in human disease. It consists of nine chapters organized into two sections on molecular mechanisms in controlling gene expression and the relationships between transcriptional control and human disease.
    Keywords: Pre-clinical medicine: basic sciences ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
    Language: English
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    Telomere (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-03-31
    Description: This book, Telomere - A Complex End of a Chromosome, is organized into nine chapters containing the latest aspects of the current knowledge about the structure of telomeres and the crucial role that telomerase plays not only in maintaining chromosomal stability but also in relation to cell immortality, cell instability, and cancer biology. We now appreciate that these unusual complexes of DNA and proteins we all know as "telomeres" are dynamic and key structures that depend on telomerase and other cellular factors for continuance. Regulation of telomere activity is a dynamic area of current research, and new insights into telomeres and their role in aging and cancer, among other biological functions and pathologies, appear regularly in the scientific world. However, one fact is more than understandable in this difficult biological conundrum: the end of the telomere story is far from being totally unraveled.
    Keywords: cancer, oxidative stress, biomarkers, chemotherapy, human health, transplantation ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
    Language: English
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    Epigenetics to Optogenetics (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-03-31
    Description: Epigenetics, which deals with the study of heritable gene expression that takes place independent of changes in DNA sequence, and optogenetics, which deals with the study of genes expressed under the influence of light, are two emerging areas of study and research that have contributed immensely to our current knowledge of mechanisms and disease processes in humans. These disciplines are interrelated in the broader picture of biology and one can be used to change or modify the other. The complexity of the techniques involved in these disciplines often leads to a lack of proper understanding by researchers from other disciplines and the scientific community at large. As such, this book provides simple and easy-to-follow explanations of some of the most exciting areas of research in these disciplines.
    Keywords: Pre-clinical medicine: basic sciences ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
    Language: English
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    In Vivo and Ex Vivo Gene Therapy for Inherited and Non-Inherited Disorders (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-03-31
    Description: Ongoing advances in pharmaceutical biotechnology have paved the way to ground-breaking new biological therapeutic modalities, offering the possibility of a durable curative approach for a number of life-threatening diseases, for which the medical need is as yet unmet. Over the past decades, gene therapy has seen a massive transformation from a proof-of-concept approach to a clinical reality culminating in the regulatory approval of state-of-the-art products in the European Union and in the United States. This book captures some of the scientific progresses notably in gene transfer technologies and translational development of in vivo and ex vivo gene therapy interventions in the treatment of a broad range of complex and debilitating non-inherited and inherited disorders such as: human immunodeficiency virus 1 (HIV-1) infection, cancer, cystic fibrosis, hereditary retinopathies, haemophilia B, cardiac diseases, and chronic liver fibrosis.
    Keywords: nanoparticles, heart failure, drug delivery, vaccine, hiv, cardiomyopathy ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
    Language: English
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    Recent Advances in Chemical Kinetics (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-05
    Description: Recent Advances in Chemical Kinetics provides a comprehensive overview of several types of chemical reactions. It includes six chapters that discuss solvent catalysis, customized flow reactors, p-conjugation in kinetics, kinetics of autoxidation, molecular chameleon for cations and anions, and internal clocks of atoms.
    Keywords: Chemistry ; thema EDItEUR::P Mathematics and Science::PN Chemistry::PNR Physical chemistry
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    Genetic Diversity (2023)
    IntechOpen | IntechOpen
    Details
    Publication Date: 2024-03-31
    Description: Genetic diversity is the entire amount of genes and genotypes in a group of organisms and is of vital importance for their adaptation to different living conditions. If, for example, all humans were identical, the extinction of the entire kind could happen very fast. Let us care and nourish differences! The goal of this book is to present some of the contemporary thoughts on understandings of the genetic diversity patterns and their altering in a changing world. The book is aimed to the ones inspired to study and contemplate genetic diversity and to the audience beyond any frames.
    Keywords: environment, biodiversity, mutation, polymorphism, hiv-1, legislation ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
    Language: English
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    Plasmid (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-03-31
    Description: This book captures in a single volume the wealth of information on the plasmid structure, function, and biology of all organisms that have been examined to date. Plasmids exhibit wide variations in size, modes of replication and transmission, host ranges, and the genes they carry and have provided us with a great understanding of basic life principles at the molecular level. Written by experts in the field, this book is a valuable source of up-to-date information, delivering the latest impacts on studies in the areas of plasmid types, genomes, purification analysis, and expression of recombinant proteins in bacteria. Plasmid utilization in the synthesis of plasmid-based vaccines, plasmids as genetic tools, and their applications in ecology and the evolutionary process are also covered. This book is a single source of valuable information for instructors and students in advanced undergraduate and graduate courses on plasmids. It will also appeal to researchers seeking to find new relationships between biological processes that are linked by plasmids to the environment.
    Keywords: immunotherapy, calcium, infectious diseases, vaccines, antigen, rna ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
    Language: English
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    Astrocyte (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-01
    Description: A team of authors from prestigious academic schools contributed to draw up a project that would give a detailed account of astrocyte's morphology and physiology, examining thoroughly all the astrocyte's types; giving an accurate description of their morphology, location, function in the brain; and illustrating their physiology and pathology in terms of dealing with neurons through "gliotransmitters," ionic channels, and membrane receptors expression. This book gives an overview of the crucial role of astrocytes in the physiology of the CNS and in the pathogenesis of several CNS disorders suggesting that the shift from a neurocentric view to one that incorporates astrocytes in disease models for drug discovery is a critical step in renewing drug development strategies to treat neurodegenerative diseases.
    Keywords: neurodegeneration, astrocytes, signal transduction, astrogliosis, cancer, alzheimer’s disease ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology
    Language: English
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    Cytogenetics (2023)
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    Publication Date: 2024-03-31
    Description: This edited book, Cytogenetics - Classical and Molecular Strategies for Analysing Heredity Material, presents recent advances in the field of cytogenetics, paying special attention to methodological achievements developed worldwide that have driven the field forward. The contributors clearly discuss several concepts and approaches useful for understanding chromosomal structure and function at its various levels, highlighting chromosomes as visible carriers of heredity material.
    Keywords: chromatin, aneuploidy, chromosomes, next-generation sequencing, in vitro fertilization, acute lymphoblastic leukemia ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
    Language: English
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    Genetic Diversity in Microorganisms (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-03-31
    Description: Genetic Diversity in Microorganisms presents chapters revealing the magnitude of genetic diversity of microorganisms living in different environmental conditions. The complexity and diversity of microbial populations is by far the highest among all living organisms. The diversity of microbial communities and their ecologic roles are being explored in soil, water, on plants and in animals, and in extreme environments such as the arctic deep-sea vents or high saline lakes. The increasing availability of PCR-based molecular markers allows the detailed analyses and evaluation of genetic diversity in microorganisms. The purpose of the book is to provide a glimpse into the dynamic process of genetic diversity of microorganisms by presenting the thoughts of scientists who are engaged in the generation of new ideas and techniques employed for the assessment of genetic diversity, often from very different perspectives. The book should prove useful to students, researchers, and experts in the area of microbial phylogeny, genetic diversity, and molecular biology.
    Keywords: Medical genetics ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
    Language: English
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    Seizures (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-01
    Description: This book contains selected peer-reviewed articles that cover novel information on epileptic seizure and psychogenic non-epileptic seizures written by international researchers. In this book, we discuss self-reporting technologies for supporting epilepsy treatment. We also discuss about the diagnostic testing in epilepsy genetic clinical practice. Clinical aspects related to diagnosis in patients presenting psychogenic non-epileptic seizures vs. epileptic seizures and neurocysticercosis are discussed as well. We delivered novel aspects about the treatment for pseudoseizures. In another chapter, the authors estimated the prevalence of ischemic stroke in epileptic patients presenting subarachnoid neurocysticercosis and ischemic stroke frequency among HIV-positive patients, and finally other authors discuss autoimmune epilepsy, its new development, and its future directions. We are looking forward with confidence and pride to the remarkable role that this book will play for a new vision and mission.
    Keywords: epilepsy, epidemiology, immunotherapy, stroke, hiv, algorithm ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology
    Language: English
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    Phylogenetics (2023)
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    Publication Date: 2024-03-31
    Description: Phylogenetics aims to study the evolutionary relatedness of living organisms in our planet. Its application is extended to the key areas such as evolution, classification and taxonomy of living organisms; ecology, diversity, and conservation biology of agrobiocenosis; monitoring of pathogen spread, outbreaks and source of transmissions, forensic analyses, etc. Historically, phylogenetics studies were prevalently based on morphological features of species that helped to classify the 'Tree of Life' on Earth. Modern phylogenetics studies, however, rely more heavily on DNA sequences. In this Phylogenetics book, we aimed to present readers the latest developments in phylogenetics studies that highlight multi-kingdom systems, reticulated evolution and conservation biology of living organisms as well as 'omics'-based phylogenetics advances.
    Keywords: bacteria, convergence, species diversity, cytogenetics, archaea ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
    Language: English
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    Current Perspectives on Less-known Aspects of Headache (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-01
    Description: Headache, as a main neurological problem in everyday life, still takes place as a contributor on top of the list of many partially solved neurological conditions. Not only primary headaches but secondary headaches are still clinical concerns of diagnosis, differential diagnosis, and therapy. This book is quite different from classical headache books. First of all, it does not contain the classical schema of a classical headache textbook. Most of the chapters composing this book contain many answers for many unanswered questions about headache in general, for example, "Is headache a genetic condition?", "What do smartphones do to our brains? Do they cause headaches?", and "Does botulinum toxin really improve chronic migraine?". We hope this book will be an interesting read and perhaps a guide in some new aspects of headache and help understand "some interesting headache issues" while stressing some of the less known mentioned above.
    Keywords: migraine, epigenetic, minimally invasive surgery, acupuncture, heart rate variability, smartphone ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology
    Language: English
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    Redox Chemistry (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-05
    Description: Redox reactions are involved in biochemistry, energy, corrosion, and much more. In both biology and electrochemistry, the redox reaction is complex and varied. For example, redox shuttles in supercapacitors show aspects of molecular electrochemistry applied to electrode porosity. In pseudocapacitors, the formalism associated with their electrochemical response requires investigation and formalism. Similarly, the simple definition of redox potential opens fundamental questions about its measurement in solutions without supporting salts. This book illustrates the variety of redox reactions in its examination of the importance of redox molecules in the development of new electrical energy storage devices.
    Keywords: Chemistry ; thema EDItEUR::P Mathematics and Science::PN Chemistry::PNR Physical chemistry::PNRH Electrochemistry and magnetochemistry
    Language: English
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    Spinal Cord Injury (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-01
    Description: Spinal cord injury is a severe scenario that may be caused by traumatic and non-traumatic vertebral or neurological disorders. Neurological impairment, chronic pain, and reduced quality of life may affect patients suffering from spinal cord injury, the onset of which may arise in an acute or chronic manner. Spinal surgeons, anesthetists, neuro-intensivists, neurologists, physiotherapists, rehabilitation medicine doctors, radiologists, neurophysiologists, and carers are all involved in the management of these patients. The chapters in this book combine a useful summary of this topic for non-expert readers with an in-depth study of medical and non-medical experts in the field.
    Keywords: apoptosis ; chronic pain ; mediterranean diet ; neuropathic pain ; neuroregeneration ; omega-3 fatty acids ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology
    Language: English
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    Mitochondrial Diseases (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-03-31
    Description: Mitochondria are crucial organelles for any cell type. Mitochondria take responsibility for not only energy production but also regulation of cell death, also called apoptosis; calcium storage; and heat production. Therefore, mitochondrial disease is implicated in the mode of action of many harmful factors for cells such as drugs and environmental contaminants, dysfunction of the oxygen transport system, malnutrition, intense exercise, and genetic variations. This book presents up-to-date knowledge about mitochondrial disease and its complex relation to some diseases such as cardiac failure, cancer, and Alzheimer's and Parkinson's diseases. This book will, therefore, be essential for readers who are interested in life sciences, especially in medicine.
    Keywords: heart failure, aging, metabolism, calcium, heart, cancer ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
    Language: English
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    Muscular Dystrophies (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-03-31
    Description: Skeletal muscle is a highly plastic organ that is modulated by various pathways controlling protein turnover. Muscle loss is common in muscular dystrophy, in which marked loss of various proteins such as the dystrophin-glycoprotein complex occurs around muscle fibers. This book provides a comprehensive overview of the various muscular dystrophies, including characteristics, diagnosis, and classification. General treatment of drugs (e.g. corticosteroids) and physical therapy for muscular dystrophies are discussed. In addition, current applications for cell and tissue engineering using muscle stem cells or gene therapy are introduced. This book also deals with the recent advances in appropriate models of drug screening using cell cultures or mammalian organs in vitro in this field.
    Keywords: muscular dystrophy, duchenne muscular dystrophy, quality of life, pathology, physical activity, adipogenesis ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
    Language: English
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    Senescence (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-03-31
    Description: In the second half of the twentieth century, life expectancy was prolonged, and the number of elderly people increased. The effect of population aging increases in the frequency of neurodegenerative diseases such as Alzheimer's and Parkinson's diseases, epilepsy, and stroke. Also, a higher incidence of infections, autoimmune diseases, and malignant cancers is observed in elderly people. The aging process is difficult to define. Are physiological changes in elderly people controlled by specific genes? Is aging process a pathophysiology affecting different organs with different severity? Finding answers to these questions may help prevent age-related diseases and improve the quality of life of old people. This book was made as a compendium on contemporary challenges in senescence.
    Keywords: aging, inflammation, oxidative stress, alzheimer’s disease, apoptosis, epigenetics ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
    Language: English
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    Phase Equilibria With Supercritical Carbon Dioxide (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-05
    Description: We are living in a critical time, both for humanity and the planet, which has led us to look for more sustainable formulas to interact with the environment. One of the important changes in the design and operation of chemical processes is the search for environmentally friendly technologies. Supercritical carbon dioxide has been revealed as a promising environmentally friendly solvent that is energy efficient, selective and capable of reducing waste, making it a promising alternative to conventional organic solvents. However, reliable and versatile mathematical models of phase equilibrium thermodynamics are needed for the use of supercritical carbon dioxide in process design and viability studies. This book reviews experimental procedures for obtaining high-pressure phase equilibria data and describes the phase diagrams of binary mixtures and some thermodynamic models capable of determining the conditions of phase equilibria at high pressures. These concepts are applied to the components of the transesterification reaction of rac-2-pentanol with a vinyl ester, which is important in the pharmaceutical industry because (S)-2-pentanol can be obtained as a reaction product. This product is a key intermediate in the synthesis of drugs against Alzheimer’s disease.
    Keywords: Chemistry ; thema EDItEUR::P Mathematics and Science::PN Chemistry::PNR Physical chemistry
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    Neurophysiology (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-01
    Description: This book discusses timely topics in the field of neurophysiology ranging from descriptions of nerve cells and glial cells to neural networks, sensory processing, neuroplasticity, neuropathophysiology, and human behavior. As such, all organizational levels of the nervous system are considered in one or more of the book’s twelve chapters. The chapters review or present novel findings and provide the reader with an overview of the current state of the art of neurophysiology research. They discuss research advances in different brain regions and experimental models. In addition, the book contributes to the training of current and future neuroscientists and, hopefully, will lead us on the path to curing some of the biggest challenges in human health.
    Keywords: Clinical & internal medicine ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology
    Language: English
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    DNA Replication (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-03-31
    Description: The study of DNA advanced human knowledge in a way comparable to the major theories in physics, surpassed only by discoveries such as fire or the number zero. However, it also created conceptual shortcuts, beliefs and misunderstandings that obscure the natural phenomena, hindering its better understanding. The deep conviction that no human knowledge is perfect, but only perfectible, should function as a fair safeguard against scientific dogmatism and enable open discussion. With this aim, this book will offer to its readers 30 chapters on current trends in the field of DNA replication. As several contributions in this book show, the study of DNA will continue for a while to be a leading front of scientific activities.
    Keywords: Medical genetics ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
    Language: English
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    Genetic Diversity and Disease Susceptibility (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-03-31
    Description: Polymorphism or variation in DNA sequence can affect individual phenotypes such as color of skin or eyes, susceptibility to diseases, and response to drugs, vaccines, chemicals, and pathogens. Especially, the interfaces between genetics, disease susceptibility, and pharmacogenomics have recently been the subject of intense research activity. This book is a self-contained collection of valuable scholarly papers related to genetic diversity and disease susceptibility, pharmacogenomics, ongoing advances in technology, and analytic methods in this field. The book contains nine chapters that cover the three main topics of genetic polymorphism, genetic diversity, and disease susceptibility and pharmacogenomics. Hence, this book is particularly useful to academics, scientists, physicians, pharmacists, practicing researchers, and postgraduate students whose work relates to genetic polymorphisms.
    Keywords: cancer, pharmacogenetics, polymorphisms, molecular markers, drug development, pharmacokinetics ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
    Language: English
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    Covalent Organic Frameworks (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-05
    Description: In recent decades, artificial porous structures have attracted increasing enthusiasm from researchers inspired by the fascinating molecular pores in nature and their unique biological functions. Although substantial achievements in porous materials have been realized, the construction of topologically designed pores is still challenging. Recently, the emergence of covalent organic frameworks (COFs), which are constructed based on organic and polymer chemistry, has made it possible to design artificial pores with controlled pore size, topology and interface properties. COFs are crystalline porous materials constructed by the precise reticulation of organic building blocks via dynamic covalent bonds. Distinct from non-covalent interactions which tend to produce isostructures, covalent bonds enable accurate pore design owing to their predetermined reaction pathways. In addition, the appropriate polycondensation of organic building units enables the formation of extended two-dimensional (2D) and three-dimensional (3D) polymer architectures with periodically ordered skeletons and well-defined pores. With their large surface area, tailorable structures, and tunable chemistry, COFs are regarded as potentially superior candidates for various applications including catalysis, energy storage and conversion, mass transport and biotechnology. This book examines the historic achievement of COFs, providing clear and comprehensive guidance for researchers on their structural design, synthetic protocols and functional exploration.
    Keywords: Chemistry ; thema EDItEUR::P Mathematics and Science::PN Chemistry::PNN Organic chemistry
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    Advancement and New Understanding in Brain Injury (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-01
    Description: This book covers the latest developments in the understanding and treatment of traumatic brain injury. Various world experts authored the chapters that comprise a wealth of updated information on intracranial pressure; monitoring and diagnostic methods; neuroinflammatory responses in traumatic brain injury; cerebral palsy and Covid-19–related brain disorder; pathogenesis and prevention of fetal, neonatal, infant, and child brain injury; hyperbaric oxygenation treatment; the engineering and modeling of head injury; systematic review on early-tracheostomy; intracranial aneurysm in tuberous sclerosis complex; and the neurobehavioral and cognitive aspects of brain injury. With these complex topics, every clinician, scientist, and researcher will find this book invaluable in understanding the latest improvements and advances in the diagnosis and treatment of traumatic brain injury.
    Keywords: inflammation, traumatic brain injury, cytokines, hypoxia, ultrasound, cerebral palsy ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology
    Language: English
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    Fluoride (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-05
    Description: Fluoride covers a continuum of topics that are frequently studied in the broad area of fluoride (F) research. It provides an overview of the primary sources of environmental fluoride in typical high-fluoride environments and demonstrates the transitions and transformations that emerge and culminate in hydro-geochemical interactions that result in fluoride-fouling of large portions of the world’s water and agricultural resources. This way, the book pinpoints the connection between F enrichment of water sources and the prevalence of endemic fluorosis in certain areas of the world. In order to contribute to a better understanding of the global fluoride problem, new fluoride detection and quantification technologies are proposed with an in-depth analysis of emerging trends in the use of portable user-friendly devices in point-of-use measurements of water fluoride. This has been presented against the backdrop of a robust overview of traditional fluoride quantification methodologies that are still in wide application among the scientific communities. In addressing fluoride toxicities, which are not limited to dental and skeletal dilapidations, the authors have explored the role of natural antioxidants in ameliorating physiological fluoride-induced noxious effects in mammalian systems. Nonetheless, since community dependence on high-fluoride water due to a lack of alternative clean water sources remains to be the principal pathway of human fluoride over-exposure, a review chapter on F mitigation techniques applied all over the world is incorporated aiming at providing a succinct overview of water defluoridation techniques and strategies being used to combat the impacts of human F overexposure around the globe. Since every cloud has a silvery lining, the possibility of using ammonium fluorides as a novel reagent in mineral processing has been considered convenient industrial fluorinating agents, which present the possibility of complete regeneration that is not afforded by the reagents presently used in decomposing silicon component of the ores.
    Keywords: Chemistry ; thema EDItEUR::P Mathematics and Science::PN Chemistry::PNK Inorganic chemistry
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    The Role of Matrix Metalloproteinase in Human Body Pathologies (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-03-31
    Description: Matrix metalloproteinases (MMPs) are a family of proteolytic zinc-containing enzymes involved in physiological as well as in pathological processes in the human organism. MMPs play a key role in the remodeling of the extracellular matrix. Such a process may occur because of tissue homeostasis, morphogenesis, and tissue repair. However, remodeling could also be a part of many pathological states such as arthritis, cardiovascular diseases, neurodegenerative diseases, or impaired development in congenital anomalies. This book overviews the role of MMPs in different pathologies affecting the human body.
    Keywords: matrix metalloproteinases, mmps, biomarkers, heart failure, risk factors, atherosclerosis ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
    Language: English
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    Exploring Chemistry with Pyridine Derivatives (2023)
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    Publication Date: 2024-04-05
    Description: This book discusses the chemistry and applications of pyridine derivatives. The library of pyridine derivatives is growing steadily with numerous synthetic analogues already described and the identification of new, naturally occurring pyridine-based compounds. The book includes ten chapters organized into two parts. The first part focuses on the numerous types of reactions that arise from pyridine derivatives. The second part examines the pharmaceutical applications of pyridine derivatives as well as their usefulness as sensors for metal cations and extracting agents for platinum group metals.
    Keywords: Chemistry ; thema EDItEUR::P Mathematics and Science::PN Chemistry::PNN Organic chemistry
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    Dosimetry (2023)
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    Publication Date: 2024-04-05
    Description: The book discusses multiple issues associated with modern dosimetry in physics and treatment planning and how investigators from diverse world centers and institutions approach problem-solving in these important areas. It examines topics including pretreatment validation and factors affecting reference dosimetry. It also addresses unique issues affecting pediatric populations as well as the modern role of thermoluminescence validation. Several chapters discuss intensity modulation, including defining modern problems associated with both treatment planning and the definition of tumor and normal tissue contours. Furthermore, the book examines the role of imaging as both a vehicle to define tumor targets and normal tissue as well as a tool for dose validation.
    Keywords: Chemistry ; thema EDItEUR::P Mathematics and Science::PN Chemistry::PNR Physical chemistry::PNRL Nuclear chemistry, photochemistry and radiation
    Language: English
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    Gene Duplication (2023)
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    Publication Date: 2024-03-31
    Description: The book Gene Duplication consists of 21 chapters divided in 3 parts: General Aspects, A Look at Some Gene Families and Examining Bundles of Genes. The importance of the study of Gene Duplication stems from the realization that the dynamic process of duplication is the “sine qua non” underlying the evolution of all living matter. Genes may be altered before or after the duplication process thereby undergoing neofunctionalization, thus creating in time new organisms which populate the Earth.
    Keywords: Medical genetics ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
    Language: English
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    Caregiving and Home Care (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-01
    Description: The management of chronic diseases is one of the tasks of all members of the health team, and different models need to be applied in the practice of chronic care management. One of these models is home care services. There are two main sections in this book. In the first part of the section, the concept of caregiving and care at home is explained. In the second part, the responsibilities of caregivers at home and the responsibilities of caregivers of people who have health problems that occur during different periods of life are discussed. In the second section, the problems of caregivers are also included. I would like to think that what is quoted in this book, which contains examples from different cultures of the world for home care approaches, will contribute to the development of home care services. This book is presented to all health professionals working in the field of health services as well as health politics professionals and students trained in these areas.
    Keywords: poverty, caregivers, breast cancer, quality of life, dementia, hiv ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology
    Language: English
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    Epilepsy (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-01
    Description: According to the World Health Organization, nearly 80% of people with epilepsy live in low- and middle-income countries and could live seizure-free if properly diagnosed and treated. Among the structural and genetic triggers that may lead to epilepsy are head trauma, abnormal synaptic connectivity, receptor subunits anomalies, and atypical ionic channel function. Developing brains are specifically susceptible to seizures for many reasons, for example, the presence of enhanced excitation due to the early production of excitatory neurotransmitters, and the fact that the inhibitory neurotransmitter GABA causes excitation early in life. These studies help to clarify why the very young brain is exceptionally prone to seizures. The chapters presented in this book describe how structural, genetic, infectious, and metabolic abnormalities can lead to epileptogenesis. Nevertheless, many underlying disease mechanisms that can lead to epilepsy remain unknown.
    Keywords: neuroinflammation ; apoptosis ; parasites ; microglia ; meg ; leukoencephalopathy ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology
    Language: English
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    Desalination (2023)
    IntechOpen | IntechOpen
    Details
    Publication Date: 2024-04-05
    Description: The book comprises 14 chapters covering all the issues related to water desalination. These chapters emphasize the relationship between problems encountered with the use of feed water, the processes developed to address them, the operation of the required plants and solutions actually implemented. This compendium will assist designers, engineers and investigators to select the process and plant configuration that are most appropriate for the particular feed water to be used, for the geographic region considered, as well as for the characteristics required of the treated water produced. This survey offers a comprehensive, hierarchical and logical assessment of the entire desalination industry. It starts with the worldwide scarcity of water and energy, continues with the thermal - and membrane-based processes and, finally, presents the design and operation of large and small desalination plants. As such, it covers all the scientific, technological and economical aspects of this critical industry, not disregarding its environmental and social points of view. One of InTech's books has received widespread praise across a number of key publications. Desalination, Trends and Technologies (Ed. Schorr, M. 2011) has been reviewed in Corrosion Engineering, Science & Technology – the official magazine for the Institute of Materials, Minerals & Mining, and Taylor & Francis's Desalination Publications. Praised for its “multi-faceted content [which] contributes to enrich it,” and described as “an essential companion...[that] enables the reader to gain a deeper understanding of the desalination industry,” this book is testament to the quality improvements we have been striving towards over the last twelve months.
    Keywords: Chemistry ; thema EDItEUR::P Mathematics and Science::PN Chemistry::PNF Analytical chemistry
    Language: English
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    DNA Repair (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-03-31
    Description: This book offers a collection of chapters addressing different studies on DNA repair from a cellular and molecular point of view. The various contributions highlight the vastness of DNA repair process and the need for a deeper understanding. To this end, the recent considerations here presented can be a cue for scientists and students working on, or interested in, the subject of DNA repair in human cells. This book may suggest to readers new avenues of interplay between different kinds of DNA damage and cellular response for maintaining nuclear and mitochondrial genomic stability.
    Keywords: dna damage, mmr, oxidative stress, mitochondria, epigenetics, angiogenesis ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
    Language: English
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    Genetic Diversity (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-03-31
    Description: This book covers the dynamic process of genetic diversity in living organisms. It comprises eight chapters that address various topics, including genetic diversity in crop production, the relationship between viruses and their hosts, patterns of genetic variability in silver carp populations in Pakistan, molecular markers used for wildlife conservation, and more.
    Keywords: mitochondria ; evolution ; molecular markers ; quorum sensing ; microorganism ; bacteriophages ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
    Language: English
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    Genetic Transformation (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-03-31
    Description: Genetic transformation of plants has revolutionized both basic and applied plant research. Plant molecular biology and physiology benefit from this power fool, as well as biotechnology. This book is a review of some of the most significant achievements that plant transformation has brought to the fields of Agrobacterium biology, crop improvement and, flower, fruit and tree amelioration. Also, it examines their impact on molecular farming, phytoremediation and RNAi tools.
    Keywords: Medical genetics ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
    Language: English
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    Gene Expression and Regulation in Mammalian Cells (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-03-31
    Description: "Central dogma" was presented by Dr. Francis Crick 60 years ago. The information of nucleotide sequences on DNAs is transcribed into RNAs by RNA polymerases. We learned the mechanisms of how transcription determines function of proteins and behaviour of cells and even how it brings appearances of organisms. This book is intended for scientists and medical researchers especially who are interested in the relationships between transcription and human diseases. This volume consists of an introductory chapter and 14 chapters, divided into 4 parts. Each chapter is written by experts in the basic scientific field. A collection of articles presented by active and laboratory-based investigators provides recent advances and progresses in the field of transcriptional regulation in mammalian cells.
    Keywords: cancer, inflammation, breast cancer, melanoma, immunity, micrornas ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
    Language: English
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    Immunogenetics (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-03-31
    Description: Because genetic factors can impact immune responses, and immunogenetic associations serve as a predictor of disease development and as a biological indicator of disease progression, the study of immunogenetics is important to basic genetics and immunology, as well as to translational and individualized medicine.This book addresses a few but important issues on the subject of immunogenetics. First, it will review the role that human leukocyte antigen molecules play in the immune system and then take into consideration the effectiveness of Western blotting for the detection of immunologic proteins. The book will discuss studies on the immunogenetics of cancer and tuberculosis followed by implications for immunotherapy. Working separately, the book will also provide evidence that the application of immunogenetics has improved our understanding of brain and behavior disorders.
    Keywords: autoimmune diseases, elisa, immune modulation, immunoassay, adjuvants ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
    Language: English
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    Alzheimer's Disease Pathogenesis (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-01
    Description: Alzheimer's Disease Pathogenesis: Core Concepts, Shifting Paradigms, and Therapeutic Targets, delivers the concepts embodied within its title. This exciting book presents the full array of theories about the causes of Alzheimer's, including fresh concepts that have gained ground among both professionals and the lay public. Acknowledged experts provide highly informative yet critical reviews of the factors that most likely contribute to Alzheimer's, including genetics, metabolic deficiencies, oxidative stress, and possibly environmental exposures. Evidence that Alzheimer's resembles a brain form of diabetes is discussed from different perspectives, ranging from disease mechanisms to therapeutics. This book is further energized by discussions of how neurotransmitter deficits, neuro-inflammation, and oxidative stress impair neuronal plasticity and contribute to Alzheimer's neurodegeneration. The diversity of topics presented in just the right depth will interest clinicians and researchers alike. This book inspires confidence that effective treatments could be developed based upon the expanding list of potential therapeutic targets.
    Keywords: Neurology & clinical neurophysiology ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology
    Language: English
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    Cerebrovascular Diseases (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-01
    Description: This book elucidates the key principles of cerebrovascular diseases (CVDs) in three sections. The first section addresses relevant pathophysiological aspects, diagnosis, treatment, and complications of CVDs, the second section examines CVDs in resource-poor settings and the geriatric population, and the final section discusses atrial fibrillation and cryptogenic stroke.
    Keywords: Clinical & internal medicine ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology
    Language: English
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    Connectivity and Functional Specialization in the Brain (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-01
    Description: ‘Connectivity and Functional Specialization in the Brain’ is a topic that describes nerve cells in terms of their anatomical and functional connections. The term connectome refers to a comprehensive map of neural connections, like a wiring diagram of an organism’s nervous system. Connectomics, the study of connectomes, can be applied to individual neurons and their synaptic connections, as well as to connections between neuronal populations or to functional and structural connectivity of different brain regions. This book addresses neural connectivity at these various scales in health and disease. The chapters review novel findings related to neuroanatomy and cell biology, neurophysiology, neural plasticity, changes of connectivity in neurological disorders, and sensory system connectivity. The book provides the reader with an overview of the current state-of-the-art of research of neural connectivity and focuses on the most important evidence-based developments in this area. Individual chapters focus on recent advances in specific areas of neural connectivity and in different brain regions. All chapters represent recent contributions to the rapidly developing field of neural connectivity.
    Keywords: consciousness, cytokines, spinal cord injury, intensive care unit, brainstem, default mode network ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology
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    Advanced Gas Chromatography (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-05
    Description: Progress in agricultural, biomedical and industrial applications' is a compilation of recent advances and developments in gas chromatography and its applications. The chapters cover various aspects of applications ranging from basic biological, biomedical applications to industrial applications. Book chapters analyze new developments in chromatographic columns, microextraction techniques, derivatisation techniques and pyrolysis techniques. The book also includes several aspects of basic chromatography techniques and is suitable for both young and advanced chromatographers. It includes some new developments in chromatography such as multidimensional chromatography, inverse chromatography and some discussions on two-dimensional chromatography. The topics covered include analysis of volatiles, toxicants, indoor air, petroleum hydrocarbons, organometallic compounds and natural products. The chapters were written by experts from various fields and clearly assisted by simple diagrams and tables. This book is highly recommended for chemists as well as non-chemists working in gas chromatography.
    Keywords: Chemistry ; thema EDItEUR::P Mathematics and Science::PN Chemistry::PNF Analytical chemistry
    Language: English
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    Electrocatalysis and Electrocatalysts for a Cleaner Environment (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-05
    Description: This book discusses electrocatalysis and electrocatalysts for energy, water electrolysis, water treatment, CO2 conversion, and green chemistry. It reviews various electrocatalysts and their properties and electrochemical performances. The first section of the book covers topics in direct alcohol fuel cells including Pt-based electrocatalysts as non-carbon electrode support materials and the development of electrocatalysts for direct methanol fuel cells. The second section of the book covers various topics in electrocatalysis and electrocatalysts for a cleaner environment, including electrocatalysts for the conversion of CO2 to valuable products and SYNGAS, electrocatalysts for water electrolysis, and much more.
    Keywords: Chemistry ; thema EDItEUR::P Mathematics and Science::PN Chemistry::PNR Physical chemistry::PNRH Electrochemistry and magnetochemistry
    Language: English
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    Transcriptional and Post-transcriptional Regulation (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-03-31
    Description: This book focuses on the transcriptional and post-transcriptional gene regulations and presents a detailed portrait of many novel aspects related to highlighting the importance of key TFs in some vital biological processes, the role of certain TFs to control some infectious diseases, the role of non-coding RNAs in controlling mRNA expression, the involvement of these non-coding RNAs in diseases, and the interplay between TFs and microRNAs as key players for gene expression regulation giving a complete picture of how genes are regulated at the cellular level. The editor embarked upon this writing project entitled "Transcriptional and Post-transcriptional Regulation" to make pertinent contributions accessible to the scientific community. Hopefully, a large audience will enjoy reading and benefit from the chapters of this book.
    Keywords: dna methylation, cancer, gene expression, micrornas, epigenetic, mirnas ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
    Language: English
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    Cytogenetics (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-03-31
    Description: Cytogenetics - Past, Present, and Further Perspectives discusses events that influenced the development of cytogenetics as a specialty within biology, with special attention paid to methodological achievements developed worldwide that have driven the field forward. Improvements to the resolution of chromosome analysis followed closely the introduction of innovative analytical technologies. In that sense, this book reviews and provides a brief account of the structure of chromosomes and stresses the high structural conservation in different species with an emphasis on aspects that require further research. However, it should be kept in mind that the future of cytogenetics will likely depend on improved knowledge of chromosome structure and function.
    Keywords: chromosome, evolution, wheat, hybridization, mammals, karyotype ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
    Language: English
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    BRCA1 and BRCA2 Mutations (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-03-31
    Description: Mutations in the BRCA1/2 genes are the most common cause of hereditary breast and ovarian cancer (HBOC), and HBOC is an autosomal dominant cancer predisposition syndrome. Individuals with HBOC have a high risk for breast and ovarian cancers and a moderate risk for other cancers, such as prostate, pancreatic, melanoma, and fallopian tube cancers. The goal of screening individuals at high risk of familial cancer is either prevention (such as a change in lifestyle or diet) or early detection of cancer. The identification of BRCA mutation carriers is important, since increased surveillance, drug therapy, and prophylactic surgery can reduce cancer-related morbidity and mortality. In recent years, there has been substantial development in BRCA-associated hereditary breast and/or breast-ovarian cancer research and its clinical applications. In this context, this book consolidates the recent advances in BRCA-related cancer biology and therapeutics, covering a wide spectrum of interrelated topics. Chapters cover a wide range of topics, such as BRCA discovery, BRCA structure and function, BRCA-associated cancers, BRCA genetic testing and counselling, and more. This book is a valuable resource not only for medical and allied health students but also for researchers, clinical and nurse geneticists, genetic counselors, and physician assistants.
    Keywords: Pre-clinical medicine: basic sciences ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
    Language: English
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    COVID-19, Neuroimmunology and Neural Function (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-01
    Description: The recent and ongoing COVID-19 pandemic has changed societies and research around the world. As such, this new book examines the latest developments in the field of neuroscience related to these changes. It includes six chapters in two sections: “COVID-19 Effects: Neurology, Neuroimmunology, Neurogenesis” and “Molecular and Cellular Neurochemistry.” The first section includes chapters that address such topics as COVID’s effect on adult neurogenesis, neurological manifestations of COVID-19, and COVID-19 and seizures. Chapters in the second section discuss peripheral biomarkers in multiple sclerosis, amino acids as neurotransmitters, advancements in RNA sequencing technologies, and more.
    Keywords: Clinical & internal medicine ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology
    Language: English
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    Hypothalamus in Health and Diseases (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-01
    Description: The human hypothalamus, a small structure at the base of the brain, has strategic importance for the harmonic function of the human body. It controls the autonomic nervous system, neuroendocrine function, circadian and circannual rhythms, somatic activities, and behavior, and is situated at the borders between the brain and the body and the brain and the soul, meeting points for mind and body. The hypothalamus is involved in a wide range of higher mental functions, including attention, learning and reinforcement of mnemonic processes, emotional control, mood stability, and cognitive-emotional interactions. It also has a role to play in behavioral disorders, panic reactions, cluster headache, gelastic epilepsy, mental deficiency, periodic disorders, depression, autism, and schizophrenia, and in a substantial number of neurodegenerative diseases. It enlarges greatly the dimensions of the hypothalamic contribution in controlling psychosomatic equilibrium and retaining internal unity of the human existence.
    Keywords: alzheimer’s disease, apoptosis, aging, anatomy, circadian rhythm, electron microscopy ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology
    Language: English
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    Parkinson's Disease (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-01
    Description: Parkinson's disease (PD) is the second most common neurodegenerative disorder results due to loss of dopamine producing brain cells. Knowledge relating to PD condition has been known since 5000BC, however no effective therapeutic strategies are available till today. Therefore it is important for neurobiologists to work further by taking advantage of modern scientific methods and develop appropriate therapeutic strategies. Efforts in this direction are worthy as they will reduce the burden of PD among elderly, who are already burdened with age related systemic degenerative processes. This book is a humble effort in that progressive direction. It has chapters covering multiple aspects relating to etiology, pathophysiology of PD, available and futuristic therapeutics strategies. Therefore it will be of interest to common man, biomedical researchers and clinicians. This is one small step in a direction "to reduce the burden of neurological disease."
    Keywords: parkinson’s disease, tissue engineering, regenerative medicine, personalized medicine, phenotype, pharmacogenetics ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology
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    Surfactants and Detergents (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-05
    Description: Surfactants are ubiquitous and have applications in diverse areas, including food, cosmetics, detergents, lubricants, enhanced oil recovery (EOR), and targeted drug delivery systems. Their wide diversity of applications owes to their unique structure, namely, a hydrophilic and a hydrophobic group present in the same molecule. Although most surfactants used industrially are synthetic, there is a growing need for natural surfactants, as the latter is obtainable from renewable sources and are less toxic and highly biodegradable in contrast to their synthetic counterparts. This book is a compilation of interesting articles by various experts that cover various applications of both synthetic and natural surfactants.
    Keywords: Chemistry ; thema EDItEUR::P Mathematics and Science::PN Chemistry::PNR Physical chemistry::PNRC Colloid chemistry
    Language: English
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    Modulating Gene Expression (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-03-31
    Description: RNA interference (RNAi) is a widely used technology for gene silencing and has become a key tool in a myriad of research and lead discoveries. In recent years, the mechanism of RNAi agents has been well investigated, and the technique has been optimized for better effectiveness and safety. On the other hand, the clustered regularly interspaced short palindromic repeats (CRISPR)-associated Cas9/gRNA system is a recent, novel, targeted genome-editing technique derived from the bacterial immune system. Recent advances in gene-editing research and technologies have enabled the CRISPR Cas9 system to become a popular tool for sequence-specific gene editing to correct and modify eukaryotic systems. In this book, we will focus on the mechanisms, applications, regulations (their pros and cons), and various ways in which RNAi-based methods and CRIPSR-Cas9 technology have stimulated the modulation of gene expression, thereby making them a promising therapeutic tool to treat and prevent complex diseases and disorders.
    Keywords: machine learning, breast cancer, gene therapy, clinical trials, nanoparticle, crispr/cas9 ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
    Language: English
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    Advances in Chemical Sensors (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-05
    Description: The chemical sensor plays an essential role in the fields of environmental conservation and monitoring, disaster and disease prevention, and industrial analysis. A typical chemical sensor is a device that transforms chemical information in a selective and reversible way, ranging from the concentration of a specific sample component to total composition analysis, into an analytically useful signal. Much research work has been performed to achieve a chemical sensor with such excellent qualities as quick response, low cost, small size, superior sensitivity, good reversibility and selectivity, and excellent detection limit. This book introduces the latest advances on chemical sensors. It consists of 15 chapters composed by the researchers active in the field of chemical sensors, and is divided into 5 sections according to the classification following the principles of signal transducer. This collection of up-to-date information and the latest research progress on chemical sensor will provide valuable references and learning materials for all those working in the field of chemical sensors.
    Keywords: Chemistry ; thema EDItEUR::P Mathematics and Science::PN Chemistry::PNF Analytical chemistry
    Language: English
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    Autism (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-01
    Description: This book opens with a discussion of neurodiversity and an elaboration of the diagnosis of autism. It then examines factors correlating with autism, including sex bias, month of birth, migration and impact of infant feeding. The next section is on the impact of autism. The neurobiology and genetic section deals with epigenetics and intracellular pathways associated with etiology. The development and behaviour section deals with proprioceptive profiles and joint attention in autism. The final section focuses on interventions including mindfulness, animal assisted activity, social/cultural perspective on autism intervention and physical activity. The book is relevant to all professionals and researchers working with persons with autism, including psychiatrists/psychologists, speech and language therapists, occupational therapists, teachers, nurses and care workers.
    Keywords: epigenetics, oxidative stress, risk factors, genetics, stress, migration ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology
    Language: English
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    Distillation Processes (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-05
    Description: Distillation is an important separation technique that has been used for many centuries to exploit the volatility differences between components in a mixture. The distillation process has many variations and applications. This book includes two sections on desalination and reactive distillation. It discusses desalination in the processes of solar and membrane distillation, with a focus on the reduction of energy costs to obtain potable water. It also discusses reactive distillation, which can be used in some cases to reduce the power duty in the separation process by using the reaction heat directly in the separation. The book includes cases of mathematical modeling, simulation, and optimization of the distillation process.
    Keywords: Chemistry ; thema EDItEUR::P Mathematics and Science::PN Chemistry::PNF Analytical chemistry
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    Non-Viral Gene Therapy (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-03-31
    Description: This book focuses on recent advancement of gene delivery systems research. With the multidisciplinary contribution in gene delivery, the book covers several aspects in the gene therapy development: various gene delivery systems, methods to enhance delivery, materials with modification and multifunction for the tumor or tissue targeting. This book will help molecular biologists gain a basic knowledge of gene delivery vehicles, while drug delivery scientist will better understand DNA, molecular biology, and DNA manipulation.
    Keywords: Medical genetics ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
    Language: English
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    Recent Research on Balance Disorders (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-01
    Description: This book provides a comprehensive overview of balance disorders. It discusses the initial approach to patients with balance disorders and presents important studies in the field. It is designed for general practitioners and specialist physicians.
    Keywords: vertigo ; pain ; hearing loss ; older adults ; meniere’s disease ; head injury ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology
    Language: English
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    Chromosomal Abnormalities (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-03-31
    Description: This edited book, Chromosomal Abnormalities - A Hallmark Manifestation of Genomic Instability, contains a series of chapters highlighting several aspects related to the generation of chromosomal abnormalities in genetic material. We are extremely grateful to the authors who had contributed with valuable information about the role of genomic instability in pathological disorders as well as in the evolution process.
    Keywords: cancer, alzheimer’s disease, neurodegeneration, pathology, hybridization, drosophila ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
    Language: English
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    Botulinum Toxin Therapy Manual for Dystonia and Spasticity (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-01
    Description: Taking exception from previous publications and reviews, this handbook boldly knits botulinum toxin therapy indications in both dystonia and spasticity. Botulinum toxin therapy has indeed withstood the test of time in terms of its efficacy and safety, as applied in hyperfunctional states of the muscle and exocrine glands. Topics were chosen spanning from the basic science to the clinical applications and to instrument-guidance injections. The format was envisioned to be timely as one (either a novice or an experienced clinician) applies practical approaches with botulinum toxin therapy ranging from straightforward to challenging clinical scenarios. As well, clinicians and students alike will find the book useful in content and relevance to contemporary times. Please read with no fear and don't doubt because indeed you eventually become the winner as you finish the book.
    Keywords: Neurology & clinical neurophysiology ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology
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    Microsatellite Markers (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-03-31
    Description: Microsatellite or so-called simple sequence repeat (SSR) markers have been one of the most reliable molecular markers derived from the DNA molecule, which were widely and successfully used for more than 25 years in the genetic studies of environmental, agricultural, and biomedical sciences. The objective of this Microsatellite Markers book is to rehighlight and provide some updates on previous and recent utilization of microsatellite markers for various applications in agriculture and medicine, which void emerging opinion on "full death" of microsatellites as useful genetic markers. Chapters presented here demonstrate the future benefit of SSRs in many genetic studies as well as disease diagnosis and prognosis.
    Keywords: microsatellites, cancer, colorectal cancer, maize, livestock, genetic diversity ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
    Language: English
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    Moyamoya Disease (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-01
    Description: Moyamoya disease is a rare cerebrovascular disease most prevalent in East Asian countries. Thanks to new diagnostic capabilities, the number of cases discovered, including asymptomatic patients, has been increasing steadily. However, asymptomatic from the clinical point of view does not necessarily mean that there are no subjacent problems. Indeed, many patients harbour cognitive decline long before they exhibit clinical or radiological manifestations. The only effective treatment is surgical revascularization, either direct, indirect, or combined. Many posit that preventive surgical treatment should be considered even in asymptomatic moyamoya patients, particularly in the paediatric age group. This book expands on these ideas and examines the various aspects of this dreadful disease.
    Keywords: stroke, neuropsychology, cerebral angiography, clinical features, revascularization ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology
    Language: English
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    Restricted Growth (2023)
    IntechOpen | IntechOpen
    Details
    Publication Date: 2024-03-31
    Description: Restricted growth conditions are a group of genetic disorders with primary effect on growth (short stature); it is very heterogeneous and comprises two important categories: skeletal dysplasia and different genetic syndromes with primary effect on growth. It could also be caused by a medical condition. The book contains chapters regarding different aspects of the study of restricted growth that are divided into three broad sections. Section I: Defining Restricted Growth, Section II: Genetics and Diagnosis of Restricted Growth, and Section III: Signaling Pathways and Molecular Mechanisms of Restricted Growth. The book presents comprehensive reviews of each topic written by experts in the field. It will be the most valuable tool for physicians and life science researchers and students. We hope that the book will motivate discussion and research in this important health problem, setting the path for better therapeutic approaches.
    Keywords: growth hormone, metabolism, cartilage, tumor suppressor, genetic testing, chondrocyte ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
    Language: English
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    Huntington's Disease (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-01
    Description: Huntington's disease is a progressive neurodegenerative disorder of the brain. It is one of the quite devastating and currently incurable human conditions. Degeneration of specific types of neurons in the brain results in a triad of clinical features: serious behavioral disturbances, uncontrolled movements of body parts, and deterioration of intellectual capabilities. The underlying complex mechanisms and molecular players of the cellular cascades still need to be deciphered in detail despite considerable advances. Once solved, the related molecular mechanisms will not only enlighten the HD story but will also shed light on other polyglutamine diseases and similar brain disorders. This book, Huntington's Disease-Molecular Pathogenesis and Current Models, is planned to cover recent scientific achievements in understanding the cellular mechanisms of HD. The chapters provide comprehensive description of the key issues in HD research. In this regard, this book will serve as a source for clinicians and researchers in the field and also for life science readers in increasing their understanding and awareness of the clinical correlates, genetic aspects, neuropathological findings, and potential therapeutic interventions related to HD.
    Keywords: huntington’s disease, pluripotent stem cells, glutamate, creb, mouse models, mmr ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology
    Language: English
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    Population Genetics (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-03-31
    Description: Population genetics is a theoretical field of biology that studies allelic and genetic frequencies in living organisms, thus allowing us to infer what evolutionary processes are acting on individuals over generations and predict the adaptive consequences of these changes in the gene pool. Knowing the structure and genetic diversity of populations is essential for a proper understanding of the evolution, speciation processes, and dynamics of living beings. This knowledge is extremely useful for some practical applications, such as species management and conservation strategies, vector and pathogen monitoring and control, plant and animal breeding, and genetic improvement. This book includes carefully selected works in population genetics reviewed by geneticists.
    Keywords: Pre-clinical medicine: basic sciences ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
    Language: English
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    Paraplegia (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-01
    Description: Paraplegia - New Insights reviews different and complementary aspects of one of the most common and catastrophic conditions. The book, edited and organized into five chapters, covers the most interesting and frequently encountered scientific material on spinal cord injury and paraplegia. It is hoped that readers will not only find answers to some of their questions but also gain a detailed understanding of paraplegia and holistic approaches to its treatment.
    Keywords: spinal cord injury ; surgery ; risk factors ; rehabilitation ; quality of life ; disability ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology
    Language: English
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    Neurodegenerative Diseases (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-01
    Description: Neurodegenerative Diseases - Processes, Prevention, Protection and Monitoring focuses on biological mechanisms, prevention, neuroprotection and even monitoring of disease progression. This book emphasizes the general biological processes of neurodegeneration in different neurodegenerative diseases. Although the primary etiology for different neurodegenerative diseases is different, there is a high level of similarity in the disease processes. The first three sections introduce how toxic proteins, intracellular calcium and oxidative stress affect different biological signaling pathways or molecular machineries to inform neurons to undergo degeneration. A section discusses how neighboring glial cells modulate or promote neurodegeneration. In the next section an evaluation is given of how hormonal and metabolic control modulate disease progression, which is followed by a section exploring some preventive methods using natural products and new pharmacological targets. We also explore how medical devices facilitate patient monitoring. This book is suitable for different readers: college students can use it as a textbook; researchers in academic institutions and pharmaceutical companies can take it as updated research information; health care professionals can take it as a reference book, even patients' families, relatives and friends can take it as a good basis to understand neurodegenerative diseases.
    Keywords: Neurology & clinical neurophysiology ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology
    Language: English
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    Traumatic Brain Injury (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-01
    Description: Traumatic brain injury (TBI) syndrome has emerged as a serious health concern worldwide due to the severity of outcomes and growing socioeconomic impacts of the diseases, e.g., high cost of long-term medical care and loss of quality of life. This book focuses on the TBI pathobiology as well as on the recent developments in advanced diagnostics and acute management. The presented topics encompass personal experience and visions of the chapter contributors as well as an extensive analysis of the TBI literature. The book is addressed to a broad audience of readers from students to practicing clinicians.
    Keywords: concussion, neurodegeneration, neuroinflammation, acupuncture, herbal medicine, biomechanics ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology
    Language: English
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    DNA (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-03-31
    Description: DNA is the most important biomolecule ever discovered. Indeed, this molecule bears genetic information from one generation to another. In this regard, DNA bases have a key role in transferring genetic information and data safely. However, there are cellular, genetic, and environmental factors that may damage the different parts of DNA molecules. These damages may result in mutations and cell death. As such, several DNA repair mechanisms have evolved. Over three sections, this book examines many of these mechanisms.
    Keywords: cancer, dna repair, dna damage, genome instability, drug resistance, neurodegenerative diseases ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
    Language: English
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    Recent Advances in Noncoding RNAs (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-03-31
    Description: The discovery of noncoding RNAs (ncRNAs) is changed our understanding of genome, transcriptome, and interactions with proteome in a cell. Since the discovery of the first microRNA (miRNA) called lin-4 on Caenorhabditis elegans in 1993, our understanding of gene expression has deepened. Further miRNA discoveries have led to the investigation of new ncRNA families and their function, biogenesis, and interactions with other types of molecules. Recent developments in bioinformatics, public databases, sequencing technologies, and biochemical techniques have increased our understanding of the biogenesis, function, and interactions of ncRNAs. This book provides an overview of current ncRNA research dealing with human diseases and cancer and plant miRNAs.
    Keywords: Pre-clinical medicine: basic sciences ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
    Language: English
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    Cyclodextrins (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-05
    Description: Cyclodextrins (CDs) have attracted great interest from the research community as well as industries in an array of sectors because of their unique structural features. This book provides a comprehensive overview of CDs, beginning with their historical background. Chapters address such topics as the structure and physiochemical properties of CDs, advancements in the field, and potential applications of these materials in fields such as drug delivery and sensing. This book reveals new frontiers in the CD world and is a useful resource for organic, analytical, and supramolecular chemists as well as scientists engaged in biological and material sciences.
    Keywords: Chemistry ; thema EDItEUR::P Mathematics and Science::PN Chemistry::PNN Organic chemistry::PNNP Polymer chemistry
    Language: English
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    Sorption (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-05
    Description: The book presents a comprehensive overview of sorption, which is a multi-parametric separation process. It is extensively used in the removal of various pollutants from the tertiary stage of wastewater treatment, from leachates, etc. It discusses fundamental points of the technique as well as kinetic theories and isotherms. It also examines the synthesis and characterizations of all studied adsorbent materials to find their paths of sorption. Finally, it highlights the importance of having a cost-estimation plan for the synthesis of sorbent materials as well as predictions for their reusability.
    Keywords: Chemistry ; thema EDItEUR::P Mathematics and Science::PN Chemistry::PNR Physical chemistry::PNRX Surface chemistry and adsorption
    Language: English
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    Genetic Variation (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-03-31
    Description: Genetic diversity is one of the measures of biodiversity and has consequences in biological variation. It is crucial to understand the evolutionary and adaptative processes in all living species. This book is an interdisciplinary and integrated work that will contribute to the knowledge of academics from different areas of biological sciences. This collection of scientific papers was chosen and analyzed to offer readers a broad and integrated view of the importance of genetic diversity in the evolution and adaptation of living beings, as well as practical applications of the information needed to analyze this diversity in different organisms. This book was edited by geneticist researchers and provides academics with up-to-date and quality information on the subject.
    Keywords: molecular markers, covid-19, genetics, food security, sars-cov-2, malaria ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
    Language: English
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    Mitochondrial DNA (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-03-31
    Description: The very short genomes of mitochondria summarize the complexity of molecular biology and its interactions with cellular and whole organism biology. Studies of mitogenomes contribute to the understanding of molecular biology and evolution, and to health management. Despite or even due to their small sizes, mitogenomes continue to surprise us. Studies of mitogenomes reveal the details of molecular organization and its evolution under constraints for miniaturization.
    Keywords: oxidative stress, cancer, aging, cancer therapy, nervous system, hydrogen bond ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
    Language: English
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    Advances in DNA Repair (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-03-31
    Description: This book edition is intended to provide a concise summary for select topics in DNA repair, a field that is ever-expanding in complexity and biologic significance. The topics reviewed ranged from fundamental mechanisms of DNA repair to the interface between DNA repair and a spectrum on cellular process to the clinical relevance of DNA repair in oncologic paradigms. The information in this text should provide a foundation from which one can explore the various topics in depth. The book serve as a supplementary text in seminar courses with focus on DNA repair as well as a general reference for scholars with an interest in DNA repair.
    Keywords: Medical genetics ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
    Language: English
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    From Pathophysiology to Treatment of Huntington's Disease (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-01
    Description: Huntington’s Disease (HD) is a progressive neurodegenerative disease leading to a variety of neurological and psychiatric symptoms such as chorea, parkinsonism, oculomotor symptoms, cognitive decline, depression, suicidal ideation, and psychosis. Currently, only symptomatic treatment is available. In recent years, there has been a growing number of publications regarding pathophysiology, disease biomarkers, and possible avenues for causal therapy of HD. This book presents an overview of the most important research updates in the pathophysiology and treatment of HD, with particular reference to advances in HD neuropathology, neuroimaging, and biomarkers of HD. We also summarize possible new therapeutic targets, including cannabis-based medicine, cellular, and cell-free therapeutics. Importantly, researchers from different regions of the world have contributed to this volume as we wanted to create a balanced, inclusive, and interdisciplinary review of the topics. We hope that with this book readers will be offered a compact summary of up-to-date trends in HD research which, ultimately, will enable better diagnosis and treatment for HD patients.
    Keywords: Clinical & internal medicine ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology
    Language: English
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    Ischemic Stroke of Brain (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-01
    Description: The stroke is the third leading cause of death and disability across the globe. We have evolved from a sense of frustration and helplessness to proactive and effective management in the hyperacute and acute phase of a stroke. The aim is to salvage the ischemic brain and turn it again into a viable and functional one. Advances in imaging and newer therapeutic strategies of this devastating illness have changed our outlook. The modern management of an ischemic stroke involves intravenous thrombolysis within a window period of four and half hours. Endovascular management with newer stent retrievers has a higher rate of recanalization with an extended therapeutic window. A new era has emerged in the management of ischemic stroke treatment. This book, written by experts, aims to improve the understanding of stroke medicine for postgraduate medical students in medicine and neurology who have an interest in stroke care.
    Keywords: risk factors, cardiovascular diseases, acupuncture, herbal medicine, migraine, traditional chinese medicine ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology
    Language: English
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    Advances in Research on Down Syndrome (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-03-31
    Description: This book provides a concise yet comprehensive source of current information on Down syndrome. It focuses on exciting areas of research on chromosome editing, neurogenomics and diseases associated with Down syndrome. Research workers, scientists, medical graduates and physicians will find this book as an excellent source for consultation and references. Key features of this book are chromosome engineering in Down syndrome, mental retardation and cognitive disability, prenatal diagnosis and diseases associated with Down syndrome. Although aimed primarily for research workers on Down syndrome, we hope that the appeal of this book will extend beyond the narrow confines of academic interest and be exciting to wider audience, especially parents, relatives and health care providers who work with infants and children with Down syndrome.
    Keywords: data mining, ultrasound, mental health, screening, crispr/cas9, congenital heart disease ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
    Language: English
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    Applications of RNA-Seq and Omics Strategies (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-03-31
    Description: The large potential of RNA sequencing and other "omics" techniques has contributed to the production of a huge amount of data pursuing to answer many different questions that surround the science's great unknowns. This book presents an overview about powerful and cost-efficient methods for a comprehensive analysis of RNA-Seq data, introducing and revising advanced concepts in data analysis using the most current algorithms. A holistic view about the entire context where transcriptome is inserted is also discussed here encompassing biological areas with remarkable technological advances in the study of systems biology, from microorganisms to precision medicine.
    Keywords: gene expression, transcriptome, epigenetics, genomics, proteomics, microrna ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
    Language: English
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    Selected Topics in Myasthenia Gravis (2023)
    IntechOpen | IntechOpen
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    Publication Date: 2024-04-01
    Description: Myasthenia gravis is a rare potentially fatal chronic autoimmune disorder. Circulating autoantibodies directed against components of the neuromuscular junction of skeletal muscles, most commonly nicotinic acetylcholine receptor and associated protein in the postsynaptic membrane, block neuromuscular transmission resulting in muscle weakness. This muscle weakness typically worsens with continued activity, improves on rest, and is of variable severity ranging from mild ocular muscle weakness to severe generalized muscle weakness, involving the respiratory muscle with impending respiratory failure. The worldwide prevalence of myasthenia gravis is 100-200 per million population, affecting more than 700,000 people all over the world. The prevalence rate has increased since the 1950s due to improved diagnostic precision and decreased mortality rate.
    Keywords: pregnancy, autoimmunity, autoantibodies, crystal structure, drug therapy, neonates ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology
    Language: English
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