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  • Chemistry  (113,923)
  • Wiley-Blackwell  (113,911)
  • Springer  (11)
  • The MIT Press  (1)
  • American Association for the Advancement of Science
  • American Chemical Society (ACS)
  • American Institute of Physics
  • 2020-2024  (1)
  • 1990-1994  (50,829)
  • 1980-1984  (33,681)
  • 1975-1979  (29,412)
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  • 1
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    Frankenstein (2022)
    The MIT Press | The MIT Press
    Details
    Publication Date: 2024-03-27
    Description: The original 1818 text of Mary Shelley's classic novel, with annotations and essays highlighting its scientific, ethical, and cautionary aspects. Mary Shelley's Frankenstein has endured in the popular imagination for two hundred years. Begun as a ghost story by an intellectually and socially precocious eighteen-year-old author during a cold and rainy summer on the shores of Lake Geneva, the dramatic tale of Victor Frankenstein and his stitched-together creature can be read as the ultimate parable of scientific hubris. Victor, “the modern Prometheus,” tried to do what he perhaps should have left to Nature: create life. Although the novel is most often discussed in literary-historical terms—as a seminal example of romanticism or as a groundbreaking early work of science fiction—Mary Shelley was keenly aware of contemporary scientific developments and incorporated them into her story. In our era of synthetic biology, artificial intelligence, robotics, and climate engineering, this edition of Frankenstein will resonate forcefully for readers with a background or interest in science and engineering, and anyone intrigued by the fundamental questions of creativity and responsibility. This edition of Frankenstein pairs the original 1818 version of the manuscript—meticulously line-edited and amended by Charles E. Robinson, one of the world's preeminent authorities on the text—with annotations and essays by leading scholars exploring the social and ethical aspects of scientific creativity raised by this remarkable story. The result is a unique and accessible edition of one of the most thought-provoking and influential novels ever written. Essays by Elizabeth Bear, Cory Doctorow, Heather E. Douglas, Josephine Johnston, Kate MacCord, Jane Maienschein, Anne K. Mellor, Alfred Nordmann
    Keywords: science fiction ; gothic ; horror ; European ; British ; literature ; fiction ; cautionary tale ; STEM ; science ; bioethics ; classic ; bicentennial ; Josephine Johnston ; Cory Doctorow ; Jane Maienschein ; Kate MacCord ; Alfred Nordmann ; Elizabeth Bear ; Anne K. Mellor ; Heather E. Douglas ; Frankenstein ; Creature ; Monster ; Mary Shelley ; Makers ; women in science ; science and anti-science ; values in science ; responsible innovation ; Industrial Revolution ; Mary Wollstonecraft ; William Godwin ; Percy Bysshe Shelley ; Galvanism ; Mount Tambora ; Myths ; Two Cultures ; epistolary novel ; Victor Frankenstein ; Geneva ; Prometheus ; Arctic ; Lord Byron ; John Polidori ; ghost stories ; Revisions ; Electricity ; Lightning ; Vitalism ; Chemistry ; Extinction ; Magnetism ; Moral responsibility ; Legal responsibility ; Social responsibility ; Consequences ; Obligations ; Ethics ; Maker Culture ; DIY ; Technology Adjacent Possible ; Facebook ; Surveillance ; Aristotle ; Fetal development ; Epigenesis ; Embryo ; Person ; Technoscience ; Alchemy ; uncanny valley ; animation ; complexity ; Morality ; Monstrosity ; Christianity ; Otherness ; Gender ; Nature ; Domestic Affections ; Women ; Sexuality ; Technical Sweetness ; Los Alamos ; Trinity Test ; Scientific Responsibility ; Nuclear Weapons ; adjacent possible ; synthetic biology ; robotics ; thema EDItEUR::F Fiction and Related items::FB Fiction: general and literary::FBC Classic fiction: general and literary ; thema EDItEUR::F Fiction and Related items::FL Science fiction::FLC Classic science fiction
    Language: English
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    E-BOOK
  • 2
    Electronic Resource
    Electronic Resource
    A sulphated glycopeptide in human supragingival calculus extracts (1977)
    Springer
    Calcified tissue international 23 (1977), S. 13-17 
    Details
    ISSN: 1432-0827
    Keywords: Dental calculus ; Glycopeptide ; Chemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary A method is described for the isolation and purification of a sulphated glycopeptide from human supragingival calculus. The compound was isolated after using EDTA treatment, 2 M CaCl2 extraction, proteolytic digestion, ethanol precipitation, and finally purified by DEAE cellulose chromatography. It migrated as a single component on cellulose acetate electrophoresis, and chemical and infrared spectral analysis showed the presence of covalently attached sulphate groups. The sulphated glycopeptide was distinguished from being a sulphated glycosaminoglycan.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02012761
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  • 3
    Electronic Resource
    Electronic Resource
    Interstellar molecules (1980)
    Springer
    Journal of molecular evolution 15 (1980), S. 79-101 
    Details
    ISSN: 1432-1432
    Keywords: Molecules ; Interstellar ; Chemistry ; Isotopes ; Solar system
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The study of interstellar molecules broadly includes two areas of interest. One area uses the unique ability of molecules to act as probes of the physical conditions in the cold, dense, visually opaque component of the interstellar medium. The physical properties of this and other components of the interstellar medium are summarized. The other area deals with the chemistry of interstellar molecules, recent aspects of which are emphasized in this review. Gas-phase chemistry, shock chemistry, and grain surface chemistry are discussed in the context of recent observations. No present observations suggest that surface reactions are relevant, but neither can they be ruled out. Ion-molecule reactions are clearly operative, at least for the simpler species. Chemical isotope fractionation is reviewed, andd it is concluded that the complexities of the chemistry allow no cosmological conclusions to be drawn from observations of deuterium in interstellar molecules, while the presence of13C in interstellar molecules permits an estimate of the12C/13C ratio which is consistent with the current concepts of the nucleosynthesis history of the Galaxy. Possible connections between interstellar molecules and the early molecular history of the solar system are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01732663
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  • 4
    Electronic Resource
    Electronic Resource
    The importance of energetic particle precipitation on the chemical composition of the middle atmosphere (1980)
    Springer
    Pure and applied geophysics 118 (1980), S. 128-151 
    Details
    ISSN: 1420-9136
    Keywords: Galactic cosmic rays ; Solar proton events ; Particle precipitation ; Chemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract An assessment is made of the relative contribution of certain classes of energetic particle precipitation to the chemical composition of the middle atmosphere with emphasis placed on the production of odd nitrogen and odd hydrogen species and their subsequent role in the catalytic removal of ozone. Galactic cosmic radiation is an important source of odd nitrogen in the lower stratosphere but since the peak energy deposition occurs below the region where catalytic removal of O3 is most effective, it is questionable whether this mechanism is important in the overall terrestrial ozone budget. The precipitation of energetic solar protons can periodically produce dramatic enhancement in upper stratospheric NO. The long residence time of NO in this region of the atmosphere, where catalytic interaction with O3 is also most effective, mandates that this mechanism be included in future modelling of the global distribution of O3. Throughout the mesosphere the precipitation of energetic electrons from the outer radiation belt (60°≲Λ≲70°) can sporadically act as a major local source of odd hydrogen and odd nitrogen leading to observable O3 depletion. Future satellite studies should be directed at simultaneously measuring the precipitation flux and the concomitant atmosphere modification, and these results should be employed to develop more sophisticated models of this important coupling.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01586448
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  • 5
    Electronic Resource
    Electronic Resource
    Proteins of the periodontium (1977)
    Springer
    Calcified tissue international 23 (1977), S. 39-44 
    Details
    ISSN: 1432-0827
    Keywords: Dental cementum ; Collagen ; Protein ; Chemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary Cyanogen bromide (CNBr) peptides were prepared of the insoluble collagen of bovine dental cementum. Following chromatographic separation, the peptides were identified by their amino-acid composition. Type I collagen ([α1(I)]2α2) accounted for more than 90% of the organic matrix, while Type III collagen ([α1(III)]3) was present at a level of approximately 5%. Amino-acid analyses revealed that the CNBr peptides from α1(I) and α2 chains of cementum closely resembled the corresponding peptides from calf skin. The only systematic difference was a higher level of hydroxylation of prolyl and lysyl residues of the cementum peptides.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02012764
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  • 6
    Electronic Resource
    Electronic Resource
    Calcium deficiency, pregnancy, and lactation in rats (1977)
    Springer
    Calcified tissue international 23 (1977), S. 87-94 
    Details
    ISSN: 1432-0827
    Keywords: Calcium ; Osteoporosis ; Lactation ; Chemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary The calcium homeostatic mechanism was challenged in adult female rats by feeding them a calcium-deficient diet containing oxalate, and by subjecting them to pregnancy and lactation. The regimen caused a substantial weight loss, especially in those animals which reared their young well. Severe hypocalcaemia was observed in the lactating rats. Serum-P was slightly elevated. The content of hydroxyproline in serum was considerably elevated, reflecting the degree of calcium deprivation. Serum proteins were least influenced. The calcium depriving regimen reduced the growth of long bones, but did not stop it. The ash content of the bones was considerably reduced, the degree of reduction depended on the degree of calcium deprivation. Ash as percentage of total bone organ was reduced, but not to the same extent as total ash. Analyses of different parts of femur showed that the proximal and distal parts had lost more bone mineral than the diaphyseal shaft. The ash content of cortical bone tissue from the femur was estimated by a volumetric method. No differences were observed between test groups and controls, indicating that no measurable amounts of bone mineral had been removed from the walls of the vascular canals or by osteocytic osteolysis. Planimetric determinations on cross sections from femora disclosed that a great amount of bone had been removed from the endosteal surface of the diaphysis, while the periosteal surface demonstrated reduced bone apposition.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02012771
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  • 7
    Electronic Resource
    Electronic Resource
    Partial purification and characterization of the bone resorption factor fromActinomyces viscosus (1982)
    Springer
    Calcified tissue international 34 (1982), S. 49-53 
    Details
    ISSN: 1432-0827
    Keywords: Bacterial amphophile ; Purification ; Chemistry ; Resorption ; Ca influx ; Cyclic AMP
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary The bone resorptive factor and amphipathic antigen (AcA) previously identified by us in preparations fromActinomyces viscosus have been partially purified, characterized chemically, and compared. They elute at the same location on chromatography with Ac 22. The fatty acid composition of AcA and the bone resorptive factor is the same. Some differences in carbohydrate composition are observed. TheActinomyces factor does not affect calcium influx or cyclic AMP in isolated bone cells. Therefore it is concluded that AcA stimulates resorption either by gaining entrance into bone cells or by way of a yet undetermined second messenger.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02411208
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  • 8
    Electronic Resource
    Electronic Resource
    Modelling the constancy of X (1994)
    Springer
    Astrophysics and space science 216 (1994), S. 153-154 
    Details
    ISSN: 1572-946X
    Keywords: Chemistry ; Molecular Hydrogen ; Cloud Models
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Observations of the CO J=1-0 line are commonly used as a tracer for molecular material in clouds. The ratio of the H2 column density to the integrated intensity of this line,X, is often taken to be constant, despite theoretical and observational uncertainty. We have tried to identify how this ratio depends on cloud parameters, testing a simple theoretical argument suggesting its invariance with respect to density. The apparent constancy can be understood if clouds are clumpy on scales of Av ≈ 1-2 mag.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00982486
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  • 9
    Electronic Resource
    Electronic Resource
    Ultrastructural characterization by ruthenium red of the surface of the fat globule membrane of human and rat milk with data on carbohydrates of fractions of rat milk (1975)
    Springer
    Cell & tissue research 157 (1975), S. 17-24 
    Details
    ISSN: 1432-0878
    Keywords: Milk ; Fat globule membrane ; Carbohydrates ; Chemistry ; Ruthenium red ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The fat globules of the cream fractions of human and rat milk were stained with ruthenium red. Under the electron microscope, discrete granules and an amorphous coat of lesser density are seen at the surface of the milk fat globules. Since ruthenium red binds anionic groups selectively, it is probable that the granules containe the greatest concentration of these groups. The cream fraction of rat milk contains hexoses, hexosamines, methylpentoses and sialic acid. Methylpentoses and hexosamines are significantly enriched in the cream fraction. It is concluded that the finding of a surface coat in milk fat globules is in keeping with the Bargmann-Knoop model and suggests a distinct mechanism for carrying certain complex carbohydrates in milk. The role of the negative charges at the outer surface of the membrane coat in maintaining fat globules in suspension and in binding certain cations such as calcium is suggested.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00223228
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  • 10
    Electronic Resource
    Electronic Resource
    Progress in the research of artemisinin-related antimalarials: An update (1994)
    Springer
    Pharmacy world & science 16 (1994), S. 169-180 
    Details
    ISSN: 1573-739X
    Keywords: Antimalarials ; Artemisia annua L ; Artemisinin ; Biosynthesis ; Chemistry ; Clinical trials ; Pharmacology ; Phytochemistry ; Sesquiterpenes ; Toxicology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Artemisinin, a sesquiterpene lactone endoperoxide isolated fromArtemisia annua L., and a number of its semisynthetic derivatives have shown to possess antimalarial properties. They are all eflective againstPlasmodium parasites that are resistant to the newest and commonly used antimalarial drugs. This article gives a survey of the literature dealing with artemisinin-relaled antimalarial issues that have appeared from the end of 1989 up to the beginning of 1994. A broad range of medical and pharmaceutical disciplines is covered, including phytochemical aspects like the selection of high-producing plants, analytical procedures, and plant biotechnology. Furthermore, the organic synthesis of artemisinin derivatives is discussed, as well as their mechanism of action and antimalarial activity, metabolism and pharmacokinetics, clinical studies, sideeffects and toxicology, and biological activities other than antimalarial activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01872865
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