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  • Life Sciences (General)  (2,845)
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  • 1
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    NYU Press
    Publication Date: 2024-04-04
    Description: What sorts of cultural criticism are teachers and scholars to produce, and how can that criticism be "employed" in the culture at large? In recent years, debates about the role and direction of English departments have mushroomed into a broader controversy over the public legitimacy of literary criticism. At first glance this might seem odd: few taxpayers and legislators care whether the nation's English professors are doing justice to the project of identifying the beautiful and the sublime. But in the context of the legitimation crisis in American higher education, the image of English departments has in fact played a major role in determining public attitudes toward colleges and college faculty. Similarly, the changing economic conditions of universities have prompted many English professors to rethink their relations to their "clients," asking how literary study can serve the American public. What sorts of cultural criticism are teachers and scholars to produce, and how can that criticism be "employed" in the culture at large? In The Employment of English, Michael Bérubé, one of our most eloquent and gifted critics, examines the cultural legitimacy of literary study. In witty, engaging prose, Bérubé asserts that we must situate these questions in a context in which nearly half of all college professors are part-time labor and in which English departments are torn between their traditional mission of defining movements of literary history and protocols of textual interpretation, and their newer tasks of interrogating wider systems of signification under rubrics like "gender," "hegemony," "rhetoric," "textuality" (including film and video), and "culture." Are these new roles a betrayal of the field's founding principles, in effect a short-sighted sell-out of the discipline? Do they represent little more that an attempt to shore up the status of--and student enrollments in--English? Or are they legitimate objects of literary study, in need of public support? Simultaneously investigating the economic and the intellectual ramifications of current debates, The Employment of English provides the clearest and most condensed account of this controversy to date.
    Keywords: Astronomy ; thema EDItEUR::P Mathematics and Science::PG Astronomy, space and time
    Language: English
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  • 2
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    International Institute of Islamic Thought
    Publication Date: 2024-04-09
    Description: This volume brings together both the elementary scientific facts that any lunar calendar formulation cannot ignore and a summary of the pressing scientific questions of particular interest to the Islamic calendar. Scientific aspects of the problem are thoroughly reviewed without prejudicing the argument in purely Islamic juridical questions and differences. The results are of great significance to both Islamic scholars and the general Muslim public. The papers presented are of a high scientific quality and are followed by a unanimous statement of the professional astronomers on the scientific questions. If these conclusions are followed, the varying sets of conventions used by different Islamic populations can be made selfconsistent and free from scientific errors, even if they still differ from each other. This new edition allows the correction of errors in the first edition, makes the style more uniform among the papers, and improves the articles’ graphs and figures. It aims to serve as an effective tool for addressing the calendrical issues that motivated the conference more than being merely a historical record. A new Afterword summarizes refinements in the scientific issues that have taken place in the ten years since the conference, many of which were prompted by the work presented here.
    Keywords: Religion ; Astronomy ; Education ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs::QRP Islam::QRPF Islam: sacred texts and revered writings::QRPF1 The Koran (Qur’an) ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs::QRP Islam ; thema EDItEUR::P Mathematics and Science::PG Astronomy, space and time ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs::QRA Religion: general::QRAM Religious issues and debates::QRAM3 Religion and science ; thema EDItEUR::J Society and Social Sciences::JN Education
    Language: English
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  • 3
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    Coimbra University Press
    Publication Date: 2022-01-31
    Description: Este escrito pseudoeratosténico que se traduz nesta publicação retrata um grupo de episódios que não se limita a 12 constelações. Tampouco discorre acerca de influências/condicionalismos deterministas sobre eventualidades e comportamentos diários, mensais ou anuais das criaturas terrenas da Época Alexandrinista. Embora não se trate de um tratado astronómico e o estilo prime por um carácter simples e sucinto, muito há para descodificar nos pouco mais de quarenta episódios. De conotações astronómicas, apresenta-se como um exercício de aproximação, ao proporcionar ao recetor explicações de algo visível, mas não atingível - as constelações, através de imagens do saber comum, radicadas em cenas e aspetos mitológicos. Ademais, são vastos os topoi desenvolvidos, como philia, traição, cólera, justiça, crime e castigo, reverência, eponímia, etiologia, metamorfose, mitologia.
    Keywords: Astrology ; Tradition ; Alexandrian Era ; Religion ; Astronomy
    Language: Portuguese
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  • 4
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    De Gruyter
    Publication Date: 2024-03-28
    Description: In his last essay just weeks before his death at the age of 91, David S. Nivison says, "Breaking into a formal system - such as a chronology - must be like breaking into a code. If you are successful, success will show right off." Since the late 1970's Nivison has focused his scholarship on breaking the code of Three Dynasties (Xia, Shang, Zhou) chronology by establishing an innovative methodology based on mourning periods, astronomical phenomenon, and numerical manipulations derived from them. Nivison is most readily known in the field for revising (and then revising again) the date of the Zhou conquest of Shang, and for his theory that Western Zhou kings employed two calendars (His so-called "Two yuan" theory), the second being set in effect upon the death of the new king's predecessor and counted from the completion of post-mourning rites for him (i.e., a "second 'first' year"). Nivison's enabling discovery that the Bamboo Annal (BA) had a historical basis was initially designed to make Wang Guowei's analysis of lunar phase terms (the so-called "Four quarter" theory that separated each month into four quarters) work for Western Zhou bronze inscriptions. In order to do so he had to assume that some inscriptions used a second yuan counted from completion of mourning. The king's death was the most important event late in a reign, so this implied that a king's reign-of-record was normally counted from the second yuan, omitting initial mourning years. It follows that when the unexpressed mourning years are forgotten (or edited out) but the dates of the beginning and end of the dynasty are still known, the remaining reigns-of-record cluster toward the beginning and end, and a reign in the middle is enlarged. Problems, ideas, and solutions like the one described above are found throughout this new collection of important works on chronology, astronomy, and historiography.
    Keywords: China ; Chronology ; Astronomy ; Historiography ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GT Interdisciplinary studies::GTM Regional / International studies ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::N History and Archaeology::NH History::NHM Australasian and Pacific history
    Language: English
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  • 5
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    World Scientific Publishing Co.
    Publication Date: 2022-01-31
    Description: This book summarizes the science to be carried out by the upcoming Cherenkov Telescope Array, a major ground-based gamma-ray observatory that will be constructed over the next six to eight years. The major scientific themes, as well as core program of key science projects, have been developed by the CTA Consortium, a collaboration of scientists from many institutions worldwide. CTA will be the major facility in high-energy and very high-energy photon astronomy over the next decade and beyond. CTA will have capabilities well beyond past and present observatories. Thus, CTA's science program is expected to be rich and broad and will complement other major multiwavelength and multimessenger facilities. This book is intended to be the primary resource for the science case for CTA and it thus will be of great interest to the broader physics and astronomy communities. The electronic version (e-book) is available in open access.
    Keywords: Gamma Rays ; Astrophysics ; Cherenkov Telescope Array (CTA) ; Cherenkov Telescopes ; Astroparticle Physics ; Multiwavelength ; Multimessenger ; Astronomy ; Dark Matter
    Language: English
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  • 6
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    transcript Verlag
    Publication Date: 2024-04-04
    Description: How does open access change science as social practice? By answering that question, this innovative book provides sociology of science with a new subject: information infrastructure research.
    Description: Frei zugängliches digitales Publizieren wird innerhalb der Scientific Community intensiv diskutiert. Dennoch ist nur wenig darüber bekannt, wie sich das wissenschaftliche Kommunikationssystem mit der Nutzung von Open Access verändert. An den Beispielen der Astronomie und Mathematik untersucht Niels Taubert im Ländervergleich Deutschland/Südafrika die Besonderheiten der darauf basierenden Sozialität und erklärt, wie die Organisation der freien Zugänglichkeit von Publikationen die Rollen der Beteiligten formt. Die Studie trägt damit nicht nur zur Etablierung einer wissenschaftssoziologischen Informationsinfrastrukturforschung bei, sondern leistet mit Blick auf die wissenschaftspolitische Debatte auch soziologische Aufklärung.
    Keywords: Open Access ; Sociology of Science ; Sociology of Technology ; Information Infrastructure ; Open Science ; Digitalization ; Digital Media ; Astronomy ; Mathematics ; Science ; Sociology ; Wissenschaftssoziologie ; Techniksoziologie ; Informationsinfrastruktur ; Open Science ; Digitalisierung ; Digitalität ; Astronomie ; Mathematik ; Wissenschaft ; Soziologie ; thema EDItEUR::P Mathematics and Science::PD Science: general issues::PDR Impact of science and technology on society
    Language: German
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  • 7
    Publication Date: 2022-01-31
    Description: By creating this comic, Living Science joins the celebrations of the 100th anniversary of the expeditions to the island of Príncipe in São Tomé e Príncipe, and Sobral, in Brazil, which allowed proof of the theory of General Relativity previously predicted by Albert Einstein. This comic will be disseminated and distributed on a large scale and aims to the presentation of the theory of General Relativity, using language understandable throughout the public. In addition, it is intended that the general public be able to value the expeditions made to Island of Príncipe and Sobral by astronomers portrayed here.
    Keywords: Science communication ; History of science ; Astronomy ; Physics
    Language: Portuguese
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  • 8
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    Schöningh and Fink Social Sciences
    Publication Date: 2024-04-04
    Description: Welche Auswirkungen hat die Ausweitung des Erzählens auf die Galaxis eigentlich für das Erzählen selbst? Und inwiefern zeichnet die galaktische Einbildungskraft nicht nur verantwortlich für Umbrüche auf dem Feld des astronomischen Wissens, sondern auch auf dem Feld der literarischen Ästhetik? Der vorliegende Band nimmt sich dieser Fragen an und lässt dabei die Imagination des Außerirdischen in ihren historischen Verlaufsformen, ihrer epistemologischen Fundierung wie vor allem auch in ihrer poetischen Funktionalität sichtbar werden.
    Keywords: Astronomy ; thema EDItEUR::P Mathematics and Science::PG Astronomy, space and time
    Language: German
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  • 9
    Publication Date: 2009-01-06
    Description: Self-gravity plays a decisive role in the final stages of star formation, where dense cores (size approximately 0.1 parsecs) inside molecular clouds collapse to form star-plus-disk systems. But self-gravity's role at earlier times (and on larger length scales, such as approximately 1 parsec) is unclear; some molecular cloud simulations that do not include self-gravity suggest that 'turbulent fragmentation' alone is sufficient to create a mass distribution of dense cores that resembles, and sets, the stellar initial mass function. Here we report a 'dendrogram' (hierarchical tree-diagram) analysis that reveals that self-gravity plays a significant role over the full range of possible scales traced by (13)CO observations in the L1448 molecular cloud, but not everywhere in the observed region. In particular, more than 90 per cent of the compact 'pre-stellar cores' traced by peaks of dust emission are projected on the sky within one of the dendrogram's self-gravitating 'leaves'. As these peaks mark the locations of already-forming stars, or of those probably about to form, a self-gravitating cocoon seems a critical condition for their existence. Turbulent fragmentation simulations without self-gravity-even of unmagnetized isothermal material-can yield mass and velocity power spectra very similar to what is observed in clouds like L1448. But a dendrogram of such a simulation shows that nearly all the gas in it (much more than in the observations) appears to be self-gravitating. A potentially significant role for gravity in 'non-self-gravitating' simulations suggests inconsistency in simulation assumptions and output, and that it is necessary to include self-gravity in any realistic simulation of the star-formation process on subparsec scales.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817203/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817203/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goodman, Alyssa A -- Rosolowsky, Erik W -- Borkin, Michelle A -- Foster, Jonathan B -- Halle, Michael -- Kauffmann, Jens -- Pineda, Jaime E -- P41 RR013218/RR/NCRR NIH HHS/ -- P41 RR013218-12/RR/NCRR NIH HHS/ -- U54 EB005149/EB/NIBIB NIH HHS/ -- U54 EB005149-05/EB/NIBIB NIH HHS/ -- U54-EB005149/EB/NIBIB NIH HHS/ -- England -- Nature. 2009 Jan 1;457(7225):63-6. doi: 10.1038/nature07609.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Initiative in Innovative Computing at Harvard, Cambridge, Massachusetts 02138, USA. agoodman@cfa.harvard.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19122636" target="_blank"〉PubMed〈/a〉
    Keywords: Algorithms ; Astronomy ; Carbon Monoxide/analysis ; Computer Simulation ; *Gravitation ; Stars, Celestial/*chemistry
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 10
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2009-01-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- New York, N.Y. -- Science. 2009 Jan 2;323(5910):32-5. doi: 10.1126/science.323.5910.32.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19119196" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Antarctic Regions ; Astronomy ; Australia ; *Autopsy ; Cause of Death ; Coroners and Medical Examiners ; Forensic Pathology ; Humans ; Male ; Methanol/*poisoning ; New Zealand ; Poisoning/diagnosis ; United States ; United States Government Agencies
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 11
    Publication Date: 2018-06-06
    Description: We present new models for illuminated accretion disks, their structure and reprocessed emission. We consider the effects of incident X-rays on the surface of an accretion disk by solving simultaneously the equations of radiative transfer, energy balance and ionization equilibrium over a large range of column densities. We assume plane-parallel geometry and azimuthal symmetry, such that each calculation corresponds to a ring at a given distance from the central object. Our models include recent and complete atomic data for K-shell of the iron and oxygen isonuclear sequences. We examine the effect on the spectrum of fluorescent Ka line emission and absorption in the emitted spectrum. We also explore the dependence of the spectrum on the strength of the incident X-rays and other input parameters, and discuss the importance of Comptonization on the emitted spectrum.
    Keywords: Astronomy
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  • 12
    Publication Date: 2018-06-06
    Description: Eta Car, with its historical outbursts, visible ejecta and massive, variable winds, continues to challenge both observers and modelers. In just the past five years over 100 papers have been published on this fascinating object. We now know it to be a massive binary system with a 5.54-year period. In January 2009, Car underwent one of its periodic low-states, associated with periastron passage of the two massive stars. This event was monitored by an intensive multi-wavelength campaign ranging from -rays to radio. A large amount of data was collected to test a number of evolving models including 3-D models of the massive interacting winds. August 2009 was an excellent time for observers and theorists to come together and review the accumulated studies, as have occurred in four meetings since 1998 devoted to Eta Car. Indeed, Car behaved both predictably and unpredictably during this most recent periastron, spurring timely discussions. Coincidently, WR140 also passed through periastron in early 2009. It, too, is a intensively studied massive interacting binary. Comparison of its properties, as well as the properties of other massive stars, with those of Eta Car is very instructive. These well-known examples of evolved massive binary systems provide many clues as to the fate of the most massive stars. What are the effects of the interacting winds, of individual stellar rotation, and of the circumstellar material on what we see as hypernovae/supernovae? We hope to learn. Topics discussed in this 1.5 day Joint Discussion were: Car: the 2009.0 event: Monitoring campaigns in X-rays, optical, radio, interferometry WR140 and HD5980: similarities and differences to Car LBVs and Eta Carinae: What is the relationship? Massive binary systems, wind interactions and 3-D modeling Shapes of the Homunculus & Little Homunculus: what do we learn about mass ejection? Massive stars: the connection to supernovae, hypernovae and gamma ray bursters Where do we go from here? (future directions) The Science Organizing Committee: Co-chairs: Augusto Damineli (Brazil) & Theodore R. Gull (USA). Members: D. John Hillier (USA), Gloria Koenigsberger (Mexico), Georges Meynet (Switzerland), Nidia Morrell (Chile), Atsuo T. Okazaki (Japan), Stanley P. Owocki (USA), Andy M.T. Pol- lock (Spain), Nathan Smith (USA), Christiaan L. Sterken (Belgium), Nicole St Louis (Canada), Karel A. van der Hucht (Netherlands), Roberto Viotti (Italy) and GerdWeigelt (Germany)
    Keywords: Astronomy
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  • 13
    Publication Date: 2018-06-06
    Description: We report the discovery with XMM-Newton of correlated spectral and timing behavior in the ultraluminous X-ray source (ULX) NGC 5408 X-1. An approx. 100 ksec pointing with XMM/Newton obtained in January, 2008 reveals a strong 10 mHz QPO in the 〉 1 keV flux, as well as flat-topped, band limited noise breaking to a power law. The energy spectrum is again dominated by two components, a 0.16 keV thermal disk and a power-law with an index of approx. 2.5. These new measurements, combined with results from our previous January 2006 pointing in which we first detected QPOs, show for the first time in a ULX a pattern of spectral and temporal correlations strongly analogous to that seen in Galactic black hole sources, but at much higher X-ray luminosity and longer characteristic time-scales. We find that the QPO frequency is proportional to the inferred disk flux, while the QPO and broad-band noise amplitude (root mean squared, rms) are inversely proportional to the disk flux. Assuming that QPO frequency scales inversely with black hole mass at a given power-law spectral index we derive mass estimates using the observed QPO frequency - spectral index relations from five stellar-mass black hole systems with dynamical mass constraints. The results from all sources are consistent with a mass range for NGC 5408 X-1 from 1000 - 9000 Stellar mass. We argue that these are conservative limits, and a more likely range is from 2000 - 5000 Stellar mass. Moreover, the recent relation from Gierlinski et al. that relates black hole mass to the strength of variability at high frequencies (above the break in the power spectrum), and the variability plane results of McHardy et al. and Koerding et al., are also suggestive of such a. high mass for NGC 5408 X-1. Importantly, none of the above estimates appears consistent with a black hole mass less than approx. 1000 Stellar mass for NGC 5408 X-1. We argue that these new findings strongly support the conclusion that NGC 5408 X-1 harbors an intermediate mass black hole.
    Keywords: Astronomy
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  • 14
    Publication Date: 2018-06-06
    Description: The James Webb Space Telescope (JWST) is the infrared successor to the Hubble Space Telescope. It is a cryogenic infrared space observatory with a 25 sq. m aperture (6 m telescope yielding diffraction limited angular resolution at a wavelength of 2 micron. The science instrument payload includes three passively cooled near-infrared instruments providing broad- and narrow-band imagery, coronagraphy, as well as multi object and integral-field spectroscopy over the 0.6 〈 0 〈 5.0 micron spectrum. An actively cooled mid-infrared instrument provides broad-band imagery, coronagraphy, and integral-field spectroscopy over the 5.0 〈 0 〈 29 micron spectrum. The JWST is being developed by NASA, in partnership with the European and Canadian Space Agencies, as a general user facility with science observations to be proposed by the international astronomical community in a manner similar to the Hubble Space Telescope. Technology development and mission design are complete, and construction is underway in all areas of the program. The JWST is on schedule to reach launch readiness during 2014.
    Keywords: Astronomy
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  • 15
    Publication Date: 2018-06-06
    Description: One of the most prominent, yet controversial associations derived from the ensemble of prompt-phase observations of gamma-ray bursts (GRBs) is the apparent correlation in the source frame between the peak energy (E(sub peak)) of the nuF(nu) spectrum and the isotropic radiated energy, E(sub iso). Since most gamma-ray bursts (GRBs) have E(sub peak) above the energy range (15-150 keV) of the Burst Alert Telescope (BAT) on Swift, determining accurate E(sub peak) values for large numbers of Swift bursts has been difficult. However, by combining data from Swift/BAT and the Suzaku Wide-band All-Sky Monitor (WAM), which covers the energy range from 50-5000 keV, for bursts which are simultaneously detected ; one can accurately fit E(sub peak) and E(sub iso) and test the relationship between them for the Swift sample. Between the launch of Suzaku in July 2005 and the end of March 2009, there were 45 gamma-ray bursts (GRBs) which triggered both Swift/BAT and WAM and an additional 47 bursts which triggered Swift and were detected by WAM, but did not trigger. A BAT-WAM team has cross-calibrated the two instruments using GRBs, and we are now able to perform joint fits on these bursts to determine spectral parameters. For those bursts with spectroscopic redshifts.. we can also calculate the isotropic energy. Here we present the results of joint Swift/BAT-Suzaku/WAM spectral fits for 86 of the bursts detected by the two instruments. We show that the distribution of spectral fit parameters is consistent with distributions from earlier missions and confirm that Swift, bursts are consistent with earlier reported relationships between Epeak and isotropic energy. We show through time-resolved spectroscopy that individual burst pulses are also consistent with this relationship.
    Keywords: Astronomy
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  • 16
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    In:  Other Sources
    Publication Date: 2018-06-11
    Description: No abstract available
    Keywords: Astronomy
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  • 17
    Publication Date: 2018-06-06
    Description: The Compact Reconnaissance Imaging Spectrometer for Mars (CRISM) onboard the Mars Reconnaissance Orbiter (MRO) spacecraft began taking observations in September 2006 and has now collected more than a full Martian year of data. Retrievals performed using the near-infrared spectra obtained by CRISM are used to characterize the seasonal and spatial variation of the column abundance of water vapor and the column-averaged mixing ratio of carbon monoxide. CRISM retrievals show nominal behavior in water vapor during northern hemisphere spring and summer with maximum abundance reaching 50 precipitable micrometers. Water vapor abundance during the southern hemisphere spring and summer appears significantly reduced compared to observations by other instruments taken during previous years. The CRISM retrievals show the seasonally and globally averaged carbon monoxide mixing ratio to be 700 ppm, but with strong seasonal variations at high latitudes. The summertime near-polar carbon monoxide mixing ratio falls to 200 ppm in the south and 400 ppm in the north as carbon dioxide sublimates from the seasonal polar ice caps and dilutes noncondensable species including carbon monoxide. At low latitudes, the carbon monoxide mixing ratio varies in response to the mean seasonal cycle of surface pressure.
    Keywords: Astronomy
    Type: Journal of Geophysical Research; Volume 114
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  • 18
    Publication Date: 2018-06-06
    Description: This is the second of two papers examining Spitzer Infrared Spectrograph (IRS) observations of the ultraluminous X-ray source (ULX) in Holmberg II. Here we perform detailed photoionization modeling of the infrared lines. Our analysis suggests that the luminosity and morphology of the [O IV] 25.89 micron emission line is consistent with photoionization by the soft X-ray and far ultraviolet (FUV) radiation from the accretion disk of the binary system and inconsistent with narrow beaming. We show that the emission nebula is matter-bounded both in the line of sight direction and to the east, and probably radiation-bounded to the west. A bolometric luminosity in excess of 10(exp 40) erg/s would be needed to produce the measured [O IV] flux. We use modeling and previously published studies to conclude that shocks likely contribute very little, if at all, to the high-excitation line fluxes observed in the Holmberg II ULX. Additionally, we find that the spectral type of the companion star has a surprisingly strong effect on the predicted strength of the [O IV] emission. This finding could explain the origin of [O IV] in some starburst systems containing black hole binaries.
    Keywords: Astronomy
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  • 19
    Publication Date: 2018-06-06
    Description: A particular periodic orbit in the Earth-Sun circular restricted three body problem is shown to have the characteristics needed for a ballistic lunar capture transfer. An injection from a circular parking orbit into the periodic orbit serves as an initial guess for a targeting algorithm. By targeting appropriate parameters incrementally in increasingly complicated force models and using precise derivatives calculated from the state transition matrix, a reliable algorithm is produced. Ballistic lunar capture trajectories in restricted four body systems are shown to be able to be produced in a systematic way.
    Keywords: Astronomy
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  • 20
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    In:  CASI
    Publication Date: 2018-06-06
    Description: Astronomers study distant galaxies by taking long exposures in deep survey fields. They choose fields that are empty of known sources, so that they are statistically representative of the Universe as a whole. Astronomers can compare the distribution of the detected galaxies in brightness, color, morphology and redshift to theoretical models, in order to puzzle out the processes of galaxy evolution. In 2004, the Hubble Space Telescope was pointed at a small, deep-survey field in the southern constellation Fornax for more than 500 hours of exposure time. The resulting Hubble Ultra-Deep Field could see the faintest and most distant galaxies that the telescope is capable of viewing. These galaxies emitted their light less than 1 billion years after the Big Bang. From the Ultra Deep Field and other galaxy surveys, astronomers have built up a history of star formation in the universe. the peak occurred about7 billion years ago, about half of the age of the current universe, then the number of stars that were forming was about 15 time the rate today. Going backward in time to when the very first starts and galaxies formed, the average star-formation rate should drop to zero. but when looking at the most distant galaxies in the Ultra Deep field, the star formation rate is still higher than it is today. The faintest galaxies seen by Hubble are not the first galaxies that formed in the early universe. To detect these galaxies NASA is planning the James Webb Space Telescope for launch in 2013. Webb will have a 6.5-meter diameter primary mirror, much bigger than Hubble's 2.4-meter primary, and will be optimized for infrared observations to see the highly redshifted galaxies.
    Keywords: Astronomy
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  • 21
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    In:  CASI
    Publication Date: 2018-06-06
    Description: An overview of the Fermi Gamma-ray Space Telescope's first 6 months in operation is provided. The Fermi Gamma-ray Space Telescope, formerly called GLAST, is a mission to measure the cosmic gamma-ray flux in the energy rage 20 MeV to more than 300 GeV, with supporting measurements for gamma-ray bursts from 8 keV to 30 MeV. It contains a Large Area Telescope capable of viewing the entire sky every 3 hours and a Gamma-ray Burst Monitor for viewing the entire unocculted sky. Since its launch on June 11, 2008 Fermi has provided information on pulsars, gamma ray bursts, relativistic jets, the active galactic nucleus, and a globular star cluster. This presentation describes Fermi's development, mission, instruments and recent findings.
    Keywords: Astronomy
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  • 22
    Publication Date: 2018-06-06
    Description: GRB 090417B was an unusually long burst with a T(sub 90) duration of at least 2130 s and a multi-peaked light curve at energies of 15-150 keV. It was optically dark and has been convincingly associated with a bright star-forming galaxy at a redshift of 0.345 that is broadly similar to the Milky Way. This is one of the few cases where a host galaxy has been clearly identified for a dark gamma-ray burst and thus an ideal candidate for studying the origin of dark bursts. We find that the dark nature of GRB 090417B can not be explained by high redshift, incomplete observations, or unusual physics in the production of the afterglow. The Swift/XRT X-ray data are consistent with the afterglow being obscured by a dense, localized sheet of dust approximately 30-80 pc from the burst along the line of sight. Assuming the standard relativistic fireball model for the afterglow we find that the optical flux is at least 2.5 mag fainter than predicted by the X -ray flux. We are able to explain the lack of an optical afterglow, and the evolution of the X -ray spectrum, by assuming that there is a sheet of dust along the line of sight approximately 30-80 pc from the progenitor. Our results suggest that this dust sheet imparts an extinction of A(sub v)〉 or = 12 mag, which is sufficient to explain the missing optical flux. GRB 090417B is an example of a gamma-ray burst that is dark due to the localized dust structure in its host galaxy.
    Keywords: Astronomy
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  • 23
    Publication Date: 2018-06-06
    Description: We presen the first Spitzer Infrared Spectrograph (IRS) observations of the [O IV] 25.89 um emission line detected from the ultraluminous X-ray source (ULX) in Holmberg II. This line is a well established signature of high excitation usually associated with AGN. Its detection suggests that the ULX has a strong impact on the surrounding gas. A Spitzer high resolution spectral map shows that the [O IV] is coincident with the X-ray position of the ULX. The ratios of the [O IV] to lower ionization lines are similar to those observed in AGN, suggesting that a strong UV and X-ray source is responsible for the, photoionization. The best XMM-Newton data is used to model the X-ray band which is then extrapolated into the UV. We perform infrared and ultraviolet photometry, and use its previously published optical and radio data to construct the full SED for the ULX and its companion. The preferred model to describe the SED includes an accretion disk which dominates the soft X-rays but contributes little at UV and optical wavelengths. The optical counterpart is consistent with a B supergiant as previously suggested in other studies. The bolometric luminosity of the ULX suggests the presence of an intermediate-mass black hole with mass 〉85 M for sub-Eddington accretion or, alternatively, a stellar-mass black hole that is accreting at super-Eddington rates. In a follow-up second paper we perform detailed photoionization modeling of the infrared lines in order to constrain the bolometric luminosity of the ULX.
    Keywords: Astronomy
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  • 24
    Publication Date: 2018-06-06
    Description: This is the second of two papers examining Spitzer Infrared Spectrograph (IRS) observations of the ultraluminous X-ray source (ULX) in Holmberg II. Here we perform detailed photoionization modeling of they infrared lines. Our analysis suggests that the luminosity and morphology of the [O IV] 25.89 micron emission line is consistent with photoionization by the soft X-ray and far ultraviolet (FUV) radiation from the accretion disk of the binary system and inconsistent with narrow beaming. We show that the emission nebula is matter-bounded both in the line of sight direction and to the east, and probably radiation-bounded to the west. A bolometric luminosity in excess of 1040 erg per second would be needed to produce the measured [O IV] flux. We use modeling and previously published studies to conclude that shacks likely contribute very little, if at all, to the high excitation line fluxes observed in the Holmberg II ULX. Additionally, we find that the spectral type of the companion star has a surprisingly strong effect on they predicted strength of the [O IV] emission. This finding could explain the origin of [O IV] hi some starburst systems containing black hole binaries.
    Keywords: Astronomy
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  • 25
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    Publication Date: 2019-07-19
    Description: Kepler is a Discovery-class mission designed to determine the frequency of Earth-size planets in and near the habitable zone of solar-like stars. The instrument consists of a 0.95 m aperture photometer designed to obtain high precision photometric measurement of 〉 100,000 stars to search for patterns of transits. The focal plane of the Schmidt-telescope contains 42 CCDs with at total of 95 mega pixels that cover 116 square degrees of sky. The photometer was launched into an Earth-trailing heliocentric orbit on March 6, 2009, finished its commissioning on May 12, and is now in the science operations mode. During the commissioning of the Kepler photometer, data were obtained at a 30 minute cadence for 53,000 stars for 9.7 days. Although the data have not yet been corrected for the presence of systematic errors and artifacts, the data show the presence of hundreds of eclipsing binary stars and variable stars of amazing variety. To provide some estimate of the capability of the photometer, a quick analysis of the photometric precision was made. Analysis of the commissioning data also show transits, occultations and light emitted from the known exoplanet HAT-P7b. The data show a smooth rise and fall of light: from the planet as it orbits its star, punctuated by a drop of 130 +/- 11 ppm in flux when the planet passes behind its star. We interpret this as the phase variation of the dayside thermal emission plus reflected light from the planet as it orbits its star and is occulted. The depth of the occultation is similar in amplitude to that expected from a transiting Earth-size planet and demonstrates that the Mission has the precision necessary to detect such planets.
    Keywords: Astronomy
    Type: ARC-E-DAA-TN937
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  • 26
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    Publication Date: 2019-07-19
    Description: We review our Suzaku observations of Broad-Line Radio Galaxies (BLRGs). The continuum above 2 approx.keV in BLRGs is dominated by emission from an accretion flow, with little or no trace of a jet, which is instead expected to emerge at GeV energies and be detected by Fermi. Concerning the physical conditions of the accretion disk, BLRGs are a mixed bag. In some sources the data suggest relatively high disk ionization, in others obscuration of the innermost regions, perhaps by the jet base. While at hard X-rays the distinction between BLRGs and Seyferts appears blurry, one of the cleanest observational differences between the two classes is at soft X-rays, where Seyferts exhibit warm absorbers related to disk winds while BLRGs do not. We discuss the possibility that jet formation inhibits disk winds, and thus is related to the remarkable dearth of absorption features at soft X-rays in BLRGs and other radio-loud AGN.
    Keywords: Astronomy
    Type: Accretion and Ejection in AGN: A Global View; Jun 22, 2009 - Jun 26, 2009; Como; Italy|The Energetic Cosmos: from Suzaku to Astro-H; Jun 29, 2009 - Jul 02, 2009; Otaru; Japan
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  • 27
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    Publication Date: 2019-07-19
    Description: At redshifts, z〉l, the rest-frame mid-UV is brought into view of large, ground-based telescopes. Here, we report on a study of the potential of the rest-frame UV spectrum for deriving the age since the last major episode of star formation in a galaxy. We base this investigation on wide-band (0.2-1.0 microns), low-resolution (R-1000) spectra of single stars in Hubble's Next Generation Spectral Library (NGSL). We find that a combination of mid-UV spectral indices and colors can indeed yield the age of a stellar population, but only if light from the stellar population is unreddened.
    Keywords: Astronomy
    Type: International Astronomical Union (IAU) XXVII; Aug 03, 2009 - Aug 14, 2009; Rio de Janeiro; Brazil|VIIth Marseille International Cosmology Conference. Harvesting the Desrt: The Universe betrween Redshifts 1 and 3; Jun 29, 2009 - Jul 03, 2009; Marseille; France
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  • 28
    Publication Date: 2019-07-19
    Description: Objectives. To provide an overview of four environmental public health surveillance projects developed by CDC and its partners for the Health and Environment Linked for Information Exchange, Atlanta (HELIX-Atlanta) and to illustrate common issues and challenges encountered in developing an environmental public health tracking system. Methods. HELIX-Atlanta, initiated in October 2003 to develop data linkage and analysis methods that can be used by the National Environmental Public Health Tracking Network (Tracking Network), conducted four projects. We highlight the projects' work, assess attainment of the HELIX-Atlanta goals and discuss three surveillance attributes. Results. Among the major challenges was the complexity of analytic issues which required multidiscipline teams with technical expertise. This expertise and the data resided across multiple organizations. Conclusions:Establishing formal procedures for sharing data, defining data analysis standards and automating analyses, and committing staff with appropriate expertise is needed to support wide implementation of environmental public health tracking.
    Keywords: Life Sciences (General)
    Type: MSFC-2199
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  • 29
    Publication Date: 2019-07-19
    Description: This 20 minute talk will review studies in the peer-reviewed literature related to the effectiveness of blood flow restricted exercise as an exercise training program. There is controversy regarding the talk with cover the effectiveness of various exercise protocols and these differences will be compared and contrasted. Unpublished data from my laboratory at Syracuse University will be presented (see other abstract), as well as some unpublished work from the labs of Manini, Clark and Rasmussen (none are NASA funded).
    Keywords: Life Sciences (General)
    Type: JSC-18254 , American College of Sports Medicine (ACSM) Symposium; May 27, 2009 - May 30, 2009; Washington; United States
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  • 30
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    Publication Date: 2019-07-19
    Description: The International X-Ray Observatory, a joint NASA-ESA-JAXA effort, is a next generation X-ray telescope that will answer many fundamental questions in contemporary astrophysics such as how do supermassive black holes influence galaxy evolution and how do galaxy clusters evolve (and how does this constrain dark energy and dark matter)? As a powerful astronomical observatory, IXO will also address questions ranging from the neutron star equation of state to the distribution and dynamical state of intergalactic material. X-ray spectroscopy, polarimetry, and timing studies provided by IXO's instruments will give detailed measures of abundances, temperatures, densities, magnetic fields and gravitational potentials. These measurements will be complementary to the next generation of observatories such as ALMA, JWST, and future ground-based optical-NIR telescopes. This mission will be ready for launch in the 2020-2021 timeframe and will launch on an Atlas V or Ariane V launch vehicle to L2. It employs a deployable optical bench to achieve the 20 meter focal length and a suite of five instruments. This talk will describe the motivating science for this mission as well as the spacecraft, instruments and optics
    Keywords: Astronomy
    Type: Steward Colloquium; Apr 15, 2009 - Apr 17, 2009; Arizona; United States
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  • 31
    Publication Date: 2019-07-19
    Description: High charge (Z) and energy (E) (HZE) nuclei comprised in the galactic cosmic rays are main contributors to space radiation risk. They induce many lesions in living matter such as non-specific oxidative damage and the double-strand breaks (DSBs), which are considered key precursors of early and late effects of radiation. There is increasing evidence that cells respond collectively rather than individually to radiation, suggesting the importance of cell signaling1. The transforming growth factor (TGF ) is a signaling peptide that is expressed in nearly all cell type and regulates a large array of cellular processes2. TGF have been shown to mediate cellular response to DNA damage3 and to induce apoptosis in non-irradiated cells cocultured with irradiated cells4. TFG molecules are secreted by cells in an inactive complex known as the latency-associated peptide (LAP). TGF is released from the LAP by a conformational change triggered by proteases, thrombospondin-1, integrins, acidic conditions and .OH radical5. TGF then binds to cells receptors and activates a cascade of events mediated by Smad proteins6, which might interfere with the repair of DNA. Meanwhile, increasingly sophisticated Brownian Dynamics (BD) algorithms have appeared recently in the literature7 and can be applied to study the interaction of molecules with receptors. These BD computer models have contributed to the elucidation of signal transduction, ligand accumulation and autocrine loops in the epidermal growth factor (EGF) and its receptor (EFGR) system8. To investigate the possible roles of TGF in an irradiated cell culture, our Monte-Carlo simulation codes of the radiation track structure9 will be used to calculate the activation of TFG triggered by .OH produced by low doses of HZE ions. The TGF molecules will then be followed by a BD algorithm in a medium representative of a cell culture to estimate the number of activated receptors.
    Keywords: Life Sciences (General)
    Type: 09-SIT-180-RRS , JSC-18147 , 55th Annual Meeting of the Radiation Research; Oct 03, 2009 - Oct 07, 2009; Savannah, GA; United States
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  • 32
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    Publication Date: 2019-07-19
    Description: This talk will focus on simulations of binary black hole mergers and the gravitational wave signals they produce. Applications to gravitational wave detection with LISA, and electro~nagnetic counterparts, will be highlighted.
    Keywords: Astronomy
    Type: Observational Signatures of Black Hole Mergers Meeting; Mar 30, 2009 - Apr 01, 2009; Maryland; United States
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  • 33
    Publication Date: 2019-07-19
    Description: The Laser Interferometer Space Antenna (LISA) is expected to detect gravitational radiation from the inspiral and merger of massive black hole binaries at high redshifts with large signal-to-noise ratios (SNRs). These high-SNR observations will make it possible to extract physical parameters such as hole masses and spins, luminosity distance, and sky position from the observed waveforms. LISA'S effectiveness as a tool for astrophysics will be influenced by the precision with which these parameters can be measured. In addition, the practicality of coordinated observations with other instruments will be affected by the temporal evolution of parameter errors such as sky position. We present estimates of parameter errors for the special case of non-spinning black holes. Our focus is on the contribution of the late inspiral and merger portions of the waveform, a regime which typically dominates the SNR but has not been extensively studied due to the historic lack of a precise description of the waveform. Advances in numerical relativity have recently made such studies possible. Initial results suggest that the portion of the waveform beyond the Schwarzchild inner-most stable circular orbit can reduce parameter uncertainties by up to a factor of two.
    Keywords: Astronomy
    Type: 2009 Meeting of the American Physical Society; May 02, 2009 - May 05, 2009; Colorado; United States
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  • 34
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    Publication Date: 2019-07-19
    Description: The author presents the current status of the RXTE/PCA Calibration, with emphasis on recent updates to the energy scale and the background subtraction. A new treatment of the Xenon K-escape line removes the largest remaining residual in the previously distributed matrices. Observations of Sco X-1 made simultaneously with Swift XRT, expressly for the purpose of cross calibrating the response to bright sources, are presented.
    Keywords: Astronomy
    Type: 4th International Astronomical Consortium for High Energy Calibration; Apr 25, 2009 - Apr 30, 2009; Tokyo; Japan
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  • 35
    Publication Date: 2019-07-19
    Description: The spacesuit water membrane evaporator (SWME) is being developed to perform the thermal control function for advanced spacesuits to take advantage of recent advances in micropore membrane technology in providing a robust heat-rejection device that is potentially less sensitive to contamination than is the sublimator. Principles of a sheet membrane SWME design were demonstrated using a prototypic test article that was tested in a vacuum chamber at JSC in July 1999. The Membrana Celgard X50-215 microporous hollow fiber (HoFi) membrane was selected after recent contamination tests as the superior candidate among commercial alternatives for HoFi SWME prototype development. Although a number of design variants were considered, one that grouped the fiber layers into stacks, which were separated by small spaces and packaged into a cylindrical shape, was deemed best for further development. An analysis of test data showed that eight layer stacks of the HoFi sheets that had good exposure on each side of the stack would evaporate water with high efficiency. A design that has 15,000 tubes, with 18 cm of exposed tubes between headers has been built and tested that meets the size, weight, and performance requirements of the SWME. This full-scale prototype consists of 30 stacks, each of which are formed into a chevron shape and separated by spacers and organized into three sectors of ten nested stacks. Testing has been performed to show contamination resistance to the constituents expected to be found in potable water produced by the distillation processes. Other tests showed the sensitivity to surfactants.
    Keywords: Life Sciences (General)
    Type: JSC-CN-19218 , 40th International Conference on Environmental Systems; Jul 11, 2010 - Jul 15, 2010; Barcelona; Spain
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  • 36
    Publication Date: 2019-07-19
    Description: The advantage of the multicolor banding in situ hybridization (mBAND) technique is its ability to identify both inter- (translocation to unpainted chromosomes) and intra- (inversions and deletions within a single painted chromosome) chromosome aberrations simultaneously. To study the detailed rearrangement of low- and high-LET radiation induced chromosome aberrations in human epithelial cells (CH184B5F5/M10) in vitro, we performed a series of experiments with Cs-137 gamma rays of both low and high dose rates, neutrons of low dose rate and 600 MeV/u Fe ions of high dose rate, with chromosome 3 painted with multi-binding colors. We also compared the chromosome aberrations in both 2- and 3-dimensional cell cultures. Results of these experiments revealed the highest chromosome aberration frequencies after low dose rate neutron exposures. However, detailed analysis of the radiation induced inversions revealed that all three radiation types induced a low incidence of simple inversions. Most of the inversions in gamma-ray irradiated samples were accompanied by other types of intra-chromosomal aberrations but few inversions were accompanied by inter-chromosomal aberrations. In contrast, neutrons and Fe ions induced a significant fraction of inversions that involved complex rearrangements of both inter- and intrachromosomal exchanges. The location of the breaks involved in chromosome exchanges was analyzed along the painted chromosome. The breakpoint distribution was found to be randomly localized on chromosome 3 after neutron or Fe ion exposure, whereas non-random distribution with clustering breakpoints was observed after -ray exposure. Our comparison of chromosome aberration yields between 2- and 3-dimensional cell cultures indicated a significant difference for gamma exposures, but not for Fe ion exposures. These experimental results indicated that the track structure of the radiation and the cellular/chromosome structure can both affect radiation-induced chromosome aberrations.
    Keywords: Life Sciences (General)
    Type: JSC-18120 , 9th International Symposium on Chromosomal Abberations; Jul 11, 2009 - Jul 12, 2009; Saint Goar; Germany
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  • 37
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    Publication Date: 2019-07-19
    Description: The James Webb Space Telescope is the successor to Hubble and will be launched into space in 2013. It is not only bigger than Hubble, but is cooled to 225 degrees below zero Centigrade in order to detect the infrared light, or heat radiation, from distant stars and galaxies. I will discuss how Webb's scientific discoveries will take us beyond Hubble, and describe some of the recent progress we have made in its construction.
    Keywords: Astronomy
    Type: Museum of Natural History: Exhibit; Jan 30, 2009 - Jan 31, 2009; Michigan; United States
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  • 38
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    Publication Date: 2019-07-19
    Description: The Fermi Gamma-ray Space Telescope, formerly called GLAST, is a mission to measure the cosmic gamma-ray flux in the energy range 20 MeV to 〉300 GeV, with supporting measurements for gamma-ray bursts from 8 keV to 30 MeV. In addition to breakthrough capabilities in energy coverage and localization, the very large field of view enables observations of 20% of the sky at any instant, and the entire sky on a timescale of a few hours. With its recent launch on 11 June 2008, Fermi now opens a new and important window on a wide variety of phenomena, including pulsars, black holes and active galactic nuclei, gamma-ray bursts, the origin of cosmic rays and supernova remnants, and searches for hypothetical new phenomena such as supersymmetric dark matter annihilations. In addition to early results and the science opportunities, this talk includes a description of the instruments and the mission status and plans.
    Keywords: Astronomy
    Type: Optical Fabrication and Testing; Jan 14, 2009; Pennsylvania; United States
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  • 39
    Publication Date: 2019-07-19
    Description: Thermal radiation from the surface of Titan reaches space through a spectral window of low opacity at 19-microns wavelength. This radiance gives a measure of the brightness temperature of the surface. Composite Infrared Spectrometer' (CIRS) observations from Cassini during its first four years at Saturn have permitted latitude mapping of zonally averaged surface temperatures. The measurements are corrected for atmospheric opacity using the dependence of radiance on emission angle. With the more complete latitude coverage and much larger dataset of CIRS we have improved upon the original results from Voyager IRIS. CIRS measures the equatorial surface brightness temperature to be 93.7+/-0.6 K, the same as the temperature measured at the Huygens landing site. The surface brightness temperature decreases by 2 K toward the south pole and by 3 K toward the north pole. The drop in surface temperature between equator and north pole implies a 50% decrease in methane saturation vapor pressure and relative humidity; this may help explain the large northern lakes. The H2 mole fraction is derived as a by-product of our analysis and agrees with previous results. Evidence of seasonal variation in surface and atmospheric temperatures is emerging from CIRS measurements over the Cassini mission.
    Keywords: Astronomy
    Type: Third Workshop on Titan Chemistry - Observations, Experiments, Computations, and Modeling; Feb 26, 2009 - Feb 28, 2009; San Juan; Puerto Rico
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  • 40
    Publication Date: 2019-07-19
    Description: Spitzer has been used to monitor the mid-IR evolution of SN 1987A over a 5 year period as it develops into a supernova remnant through interaction with its surrounding environment. This interaction is dominated by the collision of the ejecta with the pre-existing equatorial ring. The mid-IR continuum indicates an increasing mass of shock-heated silicate dust, but without any significant change in temperature of the dust grains. Comparison of the IR and X-ray evolution of the remnant can be used to infer plasma conditions and the processing of the dust in the shock-heated X-ray emitting gas.
    Keywords: Astronomy
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  • 41
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    Publication Date: 2019-07-19
    Description: An extrasolar planet sculpts the famous debris dish around Fomalhaut; probably ma ny other debris disks contain planets that we could locate if only we could better recognize their signatures in the dust that surrounds them. But the interaction between planets and debris disks involves both orbital resonances and collisions among grains and rocks in the disks --- difficult processes to model simultanemus]y. I will describe new 3-D models of debris disk dynamics that incorporate both collisions and resonant trapping of dust for the first time, allowing us to decode debris disk images and read the signatures of the planets they contain.
    Keywords: Astronomy
    Type: Satellite Workshop: Dynamics of Outer Planetary Systems; Nov 09, 2009 - Nov 11, 2009; Edinburgh, Scotland; United Kingdom
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  • 42
    Publication Date: 2019-07-19
    Description: Inspired by a recent paper (Kirsch et al. 2005) on possible use of the Crab Nebula as a standard candle for calibrating X-ray response func tions, we examine possible consequences of intrinsic departures from a single (absorbed) power law upon such calibrations. We limited our analyses to three more modern X-ray instruments -- the ROSAT/PSPC, th e RXTE/PCA, and the XMM-Newton/EPIC-pn. The results are unexpected an d indicate a need to refine two of the three response functions studi ed. The implications for Chandra will be discussed.
    Keywords: Astronomy
    Type: M09-0752 , Chandra Calibration Workshop; Sep 21, 2009; Boston, MA; United States
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  • 43
    Publication Date: 2019-07-13
    Description: In modern organisms proteins perform a majority of cellular functions, such as chemical catalysis, energy transduction and transport of material across cell walls. Although great strides have been made towards understanding protein evolution, a meaningful extrapolation from contemporary proteins to their earliest ancestors is virtually impossible. In an alternative approach, the origin of water-soluble proteins was probed through the synthesis of very large libraries of random amino acid sequences and subsequently subjecting them to in vitro evolution. In combination with computer modeling and simulations, these experiments allow us to address a number of fundamental questions about the origins of proteins. Can functionality emerge from random sequences of proteins? How did the initial repertoire of functional proteins diversify to facilitate new functions? Did this diversification proceed primarily through drawing novel functionalities from random sequences or through evolution of already existing proto-enzymes? Did protein evolution start from a pool of proteins defined by a frozen accident and other collections of proteins could start a different evolutionary pathway? Although we do not have definitive answers to these questions, important clues have been uncovered. Considerable progress has been also achieved in understanding the origins of membrane proteins. We will address this issue in the example of ion channels - proteins that mediate transport of ions across cell walls. Remarkably, despite overall complexity of these proteins in contemporary cells, their structural motifs are quite simple, with -helices being most common. By combining results of experimental and computer simulation studies on synthetic models and simple, natural channels, I will show that, even though architectures of membrane proteins are not nearly as diverse as those of water-soluble proteins, they are sufficiently flexible to adapt readily to the functional demands arising during evolution.
    Keywords: Life Sciences (General)
    Type: ARC-E-DAA-TN634 , Emergence in Chemical Systems; Jun 22, 2009 - Jun 26, 2009; Anchorage, AK; United States
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  • 44
    Publication Date: 2019-07-13
    Description: We report the detection of several molecular gas-phase and ice absorption features in three photometrically-selected young stellar object (YSO) candidates in the central 280 pc of the Milky Way. Our spectra, obtained with the Infrared Spectrograph (IRS) onboard the Spitzer Space Telescope, reveal gas-phase absorption from CO2 (15.0 microns), C2H2 (13.7 microns) and HCN (14.0 microns). We attribute this absorption to warm, dense gas in massive YSOs. We also detect strong and broad 15 microns CO2 ice absorption features, with a remarkable double-peaked structure. The prominent long-wavelength peak is due to CH3OH-rich ice grains, and is similar to those found in other known massive YSOs. Our IRS observa.tions demonstra.te the youth of these objects, and provide the first spectroscopic identification of massive YSOs in the Galactic Center.
    Keywords: Astronomy
    Type: GSFC.CP.4828.2011 , The Galactic Center: A Window to the Nuclear Environment of Disk Galaxies; Oct 19, 2009 - Oct 23, 2009; Shanghai; China|ASP Conference Series; 439; 115-118
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  • 45
    Publication Date: 2019-07-13
    Description: A normal outburst of the Be/X-ray binary system A0535+26 has taken place in August 2009. It is the fourth in a series of normal outbursts that have occurred around the periastron passage of the source. but is unusual by starting at an earlier orbital phase and by presenting a peculiar double-peaked light curve. A first "flare" (lasting about 9 days from M.ID 55043 on) reached a flux of 440 mCrab. The flux then decreased to less than 220 mCrab. and increased again reaching 440 mCrab around the periastron at MJD 55057. Target of Opportunity observations have been performed with INTEGRAL. RXTE and Suzaku. First results of these observations are presented. with special emphasis on the cyclotron lines present in the X-ray spectrum of the source. as well as in the pulse period and energy dependent pulse profiles of the source
    Keywords: Astronomy
    Type: The Extreme Sky: Sampling the Universe above 10 keV; Oct 13, 2009 - Oct 17, 2009; Otranto; Italy
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  • 46
    Publication Date: 2019-07-13
    Description: We present new results of Cassini s T9 flyby with complementary observations from T18. Based on Cassini plasma spectrometer (CAPS) and Cassini magnetometer (MAG), compositional evidence shows the upstream flow for both T9 and T18 appears composed of light ions (H+ and H2+), with external pressures approx.30 times lower than that for the earlier TA flyby where heavy ions dominated the magnetospheric plasma. When describing the plasma heating and sputtering of Titan s atmosphere, T9 and T18 can be considered interactions of low magnetospheric energy input. On the other hand, T5, when heavy ion fluxes are observed to be higher than typical (i.e., TA), represents the limiting case of high magnetospheric energy input to Titan s upper atmosphere. Beyond this distance the corona forms a neutral torus that surrounds Saturn. The T9 flyby unexpectedly resulted in observation of two wake crossings referred to as Events 1 and 2. Event 2 was evidently caused by draped magnetosphere field lines, which are scavenging pickup ions from Titan s induced magnetopause boundary with outward flux approx.2 x 10(exp 6) ions/sq cm/s. The composition of this out flow is dominated by H2+ and H+ ions. Ionospheric flow away from Titan with ion flux approx7 x 10(exp 6) ion/sq cm/s is observed for Event 1. In between Events 1 and 2 are high energy field aligned flows of magnetosphere protons that may have been accelerated by the convective electric field across Titan s topside ionosphere. T18 observations are much closer to Titan than T9, allowing one to probe this type of interaction down to altitudes approx.950 km. Comparisons with previously reported hybrid simulations are made.
    Keywords: Astronomy
    Type: Planetary and Space Science; 58; 3; 327-350
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  • 47
    Publication Date: 2019-07-12
    Description: We present new HST far-UV spectroscopy of two dozen hot evolved stars in NGC 2808, a massive globular cluster with a large population of "blue-hook" stars. The blue-hook stars are found in ultraviolet color-magnitude diagrams of the most massive globular clusters, where they fall at luminosities immediately below the hot end of the horizontal branch (HB), in a region of the HR diagram unexplained by canonical stellar evolution theory. Using new theoretical evolutionary and atmospheric models, we have shown that these subluminous HB stars are very likely the progeny of stars that undergo extensive internal mixing during a late He-core flash on the white dwarf cooling curve. This flash mixing leads to hotter temperatures and an enormous enhancement of the surface He and C abundances; the hotter temperatures and associated decrease in the hydrogen opacity shortward of the Lyman limit makes the stars brighter in the extreme UV but appear sub luminous in the UV and optical. Our far-UV spectroscopy demonstrates that, relative to normal HB stars at the same color, the blue-hook stars of NGC 2808 are hotter and greatly enhanced in He and C, thus providing unambiguous evidence of flash mixing in the subluminous population. Although the C abundance in the blue-hook stars is orders of magnitude larger than that in the normal HB stars, the atmospheric C abundance in both the blue-hook and normal HB stars appears to be affected by gravitational settling. The abundance variations seen in C, Si, and the Fe-peak elements indicate that atmospheric diffusion is at play in our sample, with all of our hot subdwarfs at 25,000 K to 50,000 K exhibiting large enhancements of the iron-peak elements. The hottest subdwarfs in our blue-hook sample may be pulsators, given that they fall in the temperature range of newly-discovered pulsating subdwarfs in omega Cen.
    Keywords: Astronomy
    Type: GSFC.JA.5514.2011
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  • 48
    Publication Date: 2019-07-19
    Description: The Moderate Resolution Imaging Spectroradiometer (MODIS) is a key instrument for NASA's EOS missions. Two nearly identical copies have flown on the Terra and Aqua spacecraft for more than 9 years and 6 years since their launch in December 1999 and May 2002, respectively. MODIS observations and associated data products have been widely used by the science community and users worldwide for studies of Earth's system of land, oceans, and atmosphere. MODIS was developed based on the desire of the science community to extend and enhance heritage sensors' data records. It was designed with enhancements made over its heritage sensors in terms of its spectral, spatial, and radiometric characteristics. It is a cross-track scanning radiometer, that uses a two-sided scan mirror, collecting data in 36 spectral bands covering spectral regions of visible (VIS), near-infrared (NIR), short-wave infrared (SWIR), mid-wave infrared (MWIR), and long-wave infrared (LWIR). The VIS, NIR, and SWIR bands (bands 1-19 and 26), which make measurements of daytime surface reflected radiances, are referred to as the reflective solar bands (RSB). The MWIR and LWIR bands (20-25 and 27-36), which measure both the daytime and nighttime scene emissive radiances, are thus referred to as the thermal emissive bands (TEB). In this paper, we provide an overview of MODIS instrument calibration and characterization methodologies, activities, and results from pre-launch to post launch, with emphasis on the lessons learned from its design to on-orbit operation. Currently, both instruments are operated normally and all the on-orbit calibration activities are performed on a regular basis with some at slightly reduced frequencies. The TEB responses have been extremely stable with less than 0.3% change per year. For the RSB, the changes are wavelength and scan angle dependent with the largest changes in the VIS spectral bands. As both Terra and Aqua MODIS continue to operate beyond their prime missions, constant effort is still needed to maintain instrument and calibration and data product quality. This paper shows that the lessons from Terra MODIS design, test, and operation, have greatly benefitted Aqua MODIS. Because of this, Aqua MODIS overall performance is better than Terra MODIS. It is not surprising that lessons from MODIS calibration and characterization, from methodologies to on-orbit implementation, have also provided valuable information for the design and development of future earth observing missions/sensors, such as VHRS on the NPP and NPOESS, ABI on GOES-R, OLI on LDCM, and the reflective solar sensor on CLARREO.
    Keywords: Astronomy
    Type: 2009 IEEE International Geoscience and Remote Sensing Symposium (IGARSS); Jul 12, 2009 - Jul 17, 2009; Cape Town; South Africa
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  • 49
    Publication Date: 2019-07-19
    Description: We present deep GALEX ultraviolet (135 - 280 nm) images of the Northern Middle Lobe (NML) of the nearby radio galaxy Centaurus A. We find that the ultraviolet emission appears to have a complex interaction with soft X-ray, H-alpha emission, and radio emission, which should help constrain various models of energy transport in the NML. We also present new 90cm VLA images of the NML. The radio morphology at this wavelength is indicative of a more complex system than either a straightforward flaring jet (Morganti et al. 1999) or a bubble with trailing stem (Saxton et al. 2001). New limits are placed on the lack of radio emission from any corresponding southern counterpart to the NML.
    Keywords: Astronomy
    Type: GALEX Helpdesk and GI Program - Inquiries 24/7 Worldwide Conference; Jun 22, 2009 - Jul 06, 2009; Sydney; Australia
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  • 50
    facet.materialart.
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    Publication Date: 2019-07-19
    Description: Band-limited masks have become the baseline design for what is now called "classical TPF" and also the N|RCamcomnagraphonJW8 .This technology remains one of the most promising paths for direct detection ofmxop|anedm and disks. I'll describe some of the latest progress in the implementation of this technique and what we have learned about where it can and can not be effectively applied.
    Keywords: Astronomy
    Type: New Technologies of Probing the Diversity of Brown Dwarfs and Exoplanets; Jul 19, 2009 - Jul 24, 2009; Shanghai; China
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  • 51
    Publication Date: 2019-07-19
    Description: Although it has now been over 50 years since mankind first ventured into space, the long-term health impacts of human space flight remain largely unknown. Identifying factors that affect survival and prognosis among those who participate in space flight is vitally important, as the era of commercial space flight approaches and NASA prepares for missions to Mars. The Longitudinal Study of Astronaut Health is a prospective study designed to examine trends in astronaut morbidity and mortality. The purpose of this analysis was to describe and explore predictors of overall and cause-specific mortality among individuals selected for the U.S. astronaut corps. All U.S. astronauts (n=321), regardless of flight status, were included in this analysis. Death certificate searches were conducted to ascertain vital status and cause of death through April 2009. Data were collected from medical records and lifestyle questionnaires. Multivariable Cox regression modeling was used to calculate the mortality hazard associated with embarking on space flight, adjusted for sex, race, and age at selection. Between 1959 and 2009, there were 39 (12.1%) deaths. Of these deaths, 18 (42.2%) were due to occupational accidents; 7 (17.9%) were due to other accidents; 6 (15.4%) were attributable to cancer; 6 (15.4%) resulted from cardiovascular/circulatory diseases; and 2 (5.1%) were from other causes. Participation in space flight did not significantly increase mortality hazard over time (adjusted hazard ratio=0.57; 95% confidence interval=0.26-1.26. Because our results are based on a small sample size, future research that includes payload specialists, other space flight participants, and international crew members is warranted to maximize statistical power.
    Keywords: Life Sciences (General)
    Type: JSC-CN-18593 , American Public Health Association Conference; Nov 07, 2009; Philadelphia, PA; United States
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  • 52
    Publication Date: 2019-07-19
    Description: The advantage of the multicolor banding in situ hybridization (mBAND) technique is not only its ability to identify simultaneously both inter- and intrachromosome exchanges, but also the ability to measure the breakpoint location along the length of the chromosome in a precision that is unmatched with other traditional banding techniques. Breakpoints on specific regions of a chromosome have been known to associate with specific cancers. The breakpoint distribution in cells after low- and high-LET radiation exposures will also provide the data for biophysical modeling of the chromatin structure, as well as the data for the modeling the formation of radiation-induced chromosome aberrations. In a series of experiments, we studied low- and high-LET radiation-induced chromosome aberrations using the mBAND technique with chromosome 3 painted in 23 different colored bands. Human epithelial cells (CH1 84B5F5/M10) were exposed in vitro to Cs- 137 rays at both low and high dose rates, secondary neutrons with a broad energy spectrum at a low dose rate and 600 MeV/u Fe ions at a high dose rate. The data of both inter- and intrachromosome aberrations involving the painted chromosome have been reported previously. Here we present data of the location of the chromosome breaks along the length of chromosome 3 in the cells after exposures to each of the four radiation scenarios. In comparison to the expected breakpoint distribution based on the length of the bands, the observed distribution appeared to be non-random for both the low- and high-LET radiations. In particular, hot spots towards both ends of the chromosome were found after low-LET irradiations of either low or high dose rates. For both high-LET radiation types (Fe ions and neutrons), the breakpoint distributions were similar, and were much smoother than that for low-LET radiation. The dependence of the breakpoint distribution on the radiation quality requires further investigations.
    Keywords: Life Sciences (General)
    Type: JSC-CN-19438 , NASA Human Research Program Investigators'' Workshop; Feb 03, 2010 - Feb 05, 2010; Houston, TX; United States
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  • 53
    Publication Date: 2019-07-19
    Description: The photometric signature of a debris object can be useful in determining what the physical characteristics of a piece of debris are. We report on optical observations in multiple filters of debris at geosynchronous Earth orbit (GEO). Our sample is taken from GEO objects discovered in a survey with the University of Michigan's 0.6-m aperture Schmidt telescope MODEST (for Michigan Orbital DEbris Survey Telescope), and then followed up in real-time with the Cerro Tololo Inter- American Observatory (CTIO) 0.9-m for orbits and photometry. Our goal is to determine 6 parameter orbits and measure colors for all objects fainter than R=15th magnitude that are discovered in the MODEST survey. At this magnitude the distribution of observed angular rates changes significantly from that of brighter objects. There are two objectives: 1. Estimate the orbital distribution of objects selected on the basis of two observational criteria: brightness (magnitude) and angular rates. 2. Obtain magnitudes and colors in standard astronomical filters (BVRI) for comparison with reflectance spectra of likely spacecraft materials. What is the faint debris likely to be? More than 90 calibrated sequences of R-B-V-I-R magnitudes for a sample of 50 objects have been obtained with the CTIO 0.9-m. For objects that do not show large brightness variations, the colors are largely redder than solar in both B-R and R-I. The width of the color distribution may be intrinsic to the nature of the surfaces, but also could be that we are seeing irregularly shaped objects and measuring the colors at different times with just one telescope. For a smaller sample of objects we have observed with synchronized CCD cameras on the two telescopes. The CTIO 0.9-m observes in B, and MODEST in R. The CCD cameras are electronically linked together so that the start time and duration of observations are the same to better than 50 milliseconds. Thus the B-R color is a true measure of the surface of the debris piece facing the telescopes for that observation. Any change in color reflects a real change in the debris surface. We will compare our observations with models and laboratory measurements of selected surfaces.
    Keywords: Astronomy
    Type: JSC-CN-18152 , AMOS Technical Conference; Sep 01, 2009 - Sep 04, 2009; Maui, HI; United States
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  • 54
    Publication Date: 2019-07-19
    Description: Purpose: To simulate radiation-induced chromosome aberrations in mammalian cells (e.g., rings, translocations, and dicentrics) and to calculate their frequency distributions following exposure to DNA double strand breaks (DSBs) produced by high-LET ions. Methods: The interphase genome was assumed to be comprised of a collection of 2 kbp rigid-block monomers following the random-walk geometry. Additional details for the modeling of chromosomal structure, such as chromosomal domains and chromosomal loops, were included. A radial energy profile for heavy ion tracks was used to simulate the high-LET pattern of induced DSBs. The induced DSB pattern depended on the ion charge and kinetic energy, but always corresponded to the DSB yield of 25 DSBs/cell/Gy. The sum of all energy contributions from Poisson-distributed particle tracks was taken to account for all possible one-track and multi-track effects. The relevant output of the model was DNA fragments produced by DSBs. The DSBs, or breakpoints, were defined by (x, y, z, l) positions, where x, y, z were the Euclidian coordinates of a DSB, and where l was the relative position along the genome. Results: The code was used to carry out Monte Carlo simulations for DSB rejoinings at low doses. The resulting fragments were analyzed to estimate the frequencies of specific types of chromosomal aberrations. Histograms for relative frequencies of chromosomal aberrations and P.D.F.s (probability density functions) of a given aberration type were produced. The relative frequency of dicentrics to rings was compared to empirical data to calibrate rejoining probabilities. Of particular interest was the predicted distribution of ring sizes, irrespective of their frequencies relative to other aberrations. Simulated ring sizes were . 4 kbp, which are far too small to be observed experimentally (i.e., by microscopy) but which, nevertheless, are conjectured to exist. Other aberrations, for example, inversions, translocations, as well as multi-centrics were also recorded. Conclusion: High-LET DNA damage affects the frequencies of chromosomal aberrations. The ratio of rings to dicentrics is correct for the genomic size cut-offs corresponding to available experimental data. The present work predicts a relative abundance of small rings following irradiation by heavy ions.
    Keywords: Life Sciences (General)
    Type: JSC-18143 , Radiation Research Society 55th Annual Meeting; Oct 04, 2009 - Oct 07, 2009; Georgia; United States
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  • 55
    Publication Date: 2019-07-19
    Description: Radio-resistant or recurrent prostate cancer represents a serious health risk for approximately 20%-30% of patients treated with primary radiation therapy for clinically localized prostate cancer. In our current studies, we investigated the expressions of apoptosis related gene expression profile (84 genes) in two distinct prostate cell lines Lncap (P53+ and AR+) and PC3 (P53- and AR-) before and after exposure to X-rays or protons, using cDNA PCR arrays. In Lncap cells, 10Gy X-ray radiation significantly induced the expression of 19 out of 84 genes at 4h after irradiation. The changed genes were mostly in death and death receptor domain families, TNF ligand and receptor families, and apoptotic group of the BCL2 family, especially in P53 related genes, such as FAS, BAX, BAK1 and GADD45A. In PC3, X-rays only induced the expression of 3 genes, including an increased expression of BIRC3. There was no difference of the X-ray mediated cell killing in both cell lines using the cell cycle analysis. However, these X-ray-induced gene expression differences between PC3 and Lncap may explain the phenotype of PC3 cells that shows more tolerant not only to radiation, but also to other apoptosis inducing and sensitizing reagents. To compare the effectiveness of cell killing with X-rays, we also exposed PC3 cells to 10Gy protons at the Bragg peak region. Protons did not induce more apoptosis than X-rays for the same dose. In comparison to X-rays, protons significantly altered expressions of 13 genes in PC3, which included decreased expressions of anti-apoptosis genes (BCL2 and BCL2L2), and increased expressions of death and death receptor domain family genes, TNF ligand and receptor family and several kinases (FAS, DAPK1 and RIPK2). These data suggest that proton treatment is more effective in influencing the apoptosis pathways in PC3 cells than X-rays, thus protons may be more effective in the treatment of specific prostate tumor.
    Keywords: Life Sciences (General)
    Type: JSC-CN-18118 , JSC-18095 , 55th Annual Meeting of the Radiation Research society; Oct 04, 2009 - Oct 07, 2009; Savannah, GA; United States|Heavy Ions in Therapy and Space Symposium 2009; Jul 06, 2009 - Jul 10, 2009; Cologne; Germany
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  • 56
    facet.materialart.
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    Publication Date: 2019-07-19
    Description: 400 years ago, Galileo first turned a telescope to the sky, and to honor that historic moment, 2009 has been designated the International Year of Astronomy (IYA2009). This session will feature two scientists who have used the telescope to understand our solar system and well beyond to yield fantastic new discoveries. Jennifer Wiseman will share the work she does with NASA, presenting beautiful and tantalizing images from the Hubble Space Telescope and discussing how space astronomy can inspire all ages.
    Keywords: Astronomy
    Type: The Evolution of Dust in the Local and Early Universe; Mar 06, 2009 - Mar 08, 2009; New York City, NY; United States
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  • 57
    Publication Date: 2019-07-19
    Description: A main contributor of fractures in older adults is from a lateral fall. The decline in sensory systems results in difficulty maintaining balance stability. Head stabilization contributes to postural control by serving as a stable platform for the sensory systems. The purpose of this study was to characterize the head stabilization response to a lateral perturbation while walking. A total of 16 healthy older adults, aged 66-81 years, walked across a foam pathway 6 times. One piece of the foam pathway covered a movable platform that translated to the left when the subject stepped on the foam. Three trials were randomized in which the platform shifted. Angular rate sensors placed on the center of mass of the head and trunk collected head and trunk movement in all three planes of motion. The roll plane was analyzed to examine motion in the plane of the perturbation. Subjects stepped onto the platform with the right foot. Recovery step time and distance were recorded. The first trial was analyzed to capture the novelty of the perturbation. Results indicate a significant difference in footfall distance t=0.004, p〈0.05, as well as the speed of foot recovery t=0.001, p〈0.05, between natural and perturbed walking. Results indicate that the head t=0.005, p〈0.05, and trunk t=0.0001, p〈0.05, velocities increase during perturbed compared to natural walking. Older adults place their recovery foot down faster when perturbed to re-establish their base of support. Head and trunk segments are less stable and move with greater velocities to reestablish stability when perturbed.
    Keywords: Life Sciences (General)
    Type: JSC-CN-18151 , JSC-CN-19226 , 62nd Annual Scientific Meeting of the Gerontological Society of America; 18-122 Nov. 2009; Atlanta, GA; United States
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  • 58
    Publication Date: 2019-07-19
    Description: During future lunar missions, exposure to solar particle events (SPEs) is a major safety concern for crew members during extra-vehicular activities (EVAs) on the lunar surface or Earth-to-moon transit. NASA s new lunar program anticipates that up to 15% of crew time may be on EVA, with minimal radiation shielding. For the operational challenge to respond to events of unknown size and duration, a probabilistic risk assessment approach is essential for mission planning and design. Using the historical database of proton measurements during the past 5 solar cycles, a typical hazard function for SPE occurrence was defined using a non-homogeneous Poisson model as a function of time within a non-specific future solar cycle of 4000 days duration. Distributions ranging from the 5th to 95th percentile of particle fluences for a specified mission period were simulated. Organ doses corresponding to particle fluences at the median and at the 95th percentile for a specified mission period were assessed using NASA s baryon transport model, BRYNTRN. The cancer fatality risk for astronauts as functions of age, gender, and solar cycle activity were then analyzed. The probability of exceeding the NASA 30- day limit of blood forming organ (BFO) dose inside a typical spacecraft was calculated. Future work will involve using this probabilistic risk assessment approach to SPE forecasting, combined with a probabilistic approach to the radiobiological factors that contribute to the uncertainties in projecting cancer risks.
    Keywords: Life Sciences (General)
    Type: JSC-18116 , 5th International Workshop on Space Radiation Research; Jul 06, 2009 - Jul 10, 2009; Cologne; Germany
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  • 59
    Publication Date: 2019-07-19
    Description: Changes of gene expression profile are one of the most important biological responses in living cells after ionizing radiation (IR) exposure. Although some studies have shown that genes up-regulated by IR may play important roles in DNA damage repair, the relationship between the regulation of gene expression by IR, particularly genes not known for their roles in double-strand break (DSB) repair, and its impact on cytogenetic responses has not been well studied. The purpose of this study is to identify new roles of IR inducible genes in radiation-induced chromosome aberrations and micronuclei formation. In the study, the expression of 25 genes selected on the basis of their transcriptional changes in response to IR was individually knocked down by small interfering RNA in human fibroblast cells. Frequencies of micronuclei (MN) formation and chromosome aberrations were measured to determine the efficiency of cytogenetic repair, and the fraction of bi-nucleated cells in the MN analysis was used as a marker for cell cycle progression. In response to gamma radiation, the formation of MN was significantly increased by suppressed expression of five genes: Ku70 (DSB repair pathway), XPA (nucleotide excision repair pathway), RPA1 (mismatch repair pathway), RAD17 and RBBP8 (cell cycle control). Knocked-down expression of four genes (MRE11A, RAD51 in the DSB pathway, SESN1, and SUMO1) significantly inhibited cell cycle progression, possibly because of severe impairment of DNA damage repair. Moreover, decreased XPA, p21, or MLH1 expression resulted in both significantly enhanced cell cycle progression and increased yields of chromosome aberrations, indicating that these gene products modulate both cell cycle control and DNA damage repair. Nine of these eleven genes, whose knock-down expression affected cytogenetic repair, were up-regulated in cells exposed to gamma radiation, suggesting that genes transcriptionally modulated by IR were critical to regulate IR-induced biological consequences. Furthermore, eight non-DBS repair genes showed involvement in regulating DSB repair, indicating that successful DSB repair requires both DSB repair mechanisms and non-DSB repair systems.
    Keywords: Life Sciences (General)
    Type: JSC-18121 , 9th International Symposium on Chromosomal; Jul 11, 2009 - Jul 12, 2009; Saint Goar; Germany
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  • 60
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    Publication Date: 2019-07-19
    Description: An extrasolar planet sculpts the famous debris disk around Fomalhaut; probably many other debris disks contain planets that we could locate if only we could better recognize their signatures in the dust that surrounds them. But the interaction between planets and debris disks involves both orbital resonances and collisions among grains and rocks in the disks---difficult processes to model simultaneously. The author describes new 3-D models of debris disk dynamics, Drag-o-llision models, that incorporate both collisions and resonant trapping of dust for the first time. The author also discusses the implications of these models for coronagraphic imaging with Gemini and other telescopes.
    Keywords: Astronomy
    Type: 2nd Subaru International Conference - Exoplanets and Disks: Their Formation and Diversity; Mar 04, 2009 - Mar 12, 2009; Hawaii; United States
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  • 61
    Publication Date: 2019-07-19
    Description: An understanding of the various sources of non-methane volatile organic compounds (NMVOCs) is one facet to ensuring the habitability of crewed spacecraft. Even though the International Space Station (ISS) atmosphere is relatively well characterized in terms of what is in the atmosphere and approximately how much, linking the majority of these trace contaminants detected to their source is virtually impossible. Albeit a few of can be associated to a single source, the majority of these trace contaminants have their origins from multiple sources. On crewed spacecraft such as ISS, trace contaminants are broadly categorized as either coming from equipment, which includes systems and payloads, or from the metabolic processes of the crew members. Such widely encompassing categories clearly illustrate the difficulty in linking air contaminants to their source(s). It is well known that microbial growth in ISS can flourish if left unchecked. Although processes are in place to limit microbial growth, in reality, microbial growth has pervaded the habitable environment of ISS. This is simply a consequence of having crewed spacecraft, as humans are the largest contributor to the bioload. As with crew members, microbes also have metabolic processes which, in many ways, are comparable to human metabolism. As such, it can be expected that microbial growth can lead to the release of volatile organic compounds into the ISS atmosphere. Given a large enough microbial population, the impact to the air quality of ISS can be potentially large. A survey of the microbiology found in ISS will be presented as well as the possible types of volatile organic compounds that can result from such organisms. This will be correlated to the observations provided by ground-based analysis of ISS atmosphere samples.
    Keywords: Life Sciences (General)
    Type: JSC-CN-19161 , International Conference on Environmental Systems; Jul 11, 2010 - Jul 15, 2010; Barcelona; Spain
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  • 62
    Publication Date: 2019-07-19
    Description: The history of the universe in a nutshell, from the Big Bang to now, and on to the future - John Mather will tell the story of how we got here, how the Universe began with a Big Bang, how it could have produced an Earth where sentient beings can live, and how those beings are discovering their history. Mather was Project Scientist for NASA s Cosmic Background Explorer (COBE) satellite, which measured the spectrum (the color) of the heat radiation from the Big Bang, discovered hot and cold spots in that radiation, and hunted for the first objects that formed after the great explosion. He will explain Einstein s biggest mistake, show how Edwin Hubble discovered the expansion of the universe, how the COBE mission was built, and how the COBE data support the Big Bang theory. He will also show NASA s plans for the next great telescope in space, the James Webb Space Telescope. It will look even farther back in time than the Hubble Space Telescope, and will look inside the dusty cocoons where stars and planets are being born today. Planned for launch in 2013, it may lead to another Nobel Prize for some lucky observer.
    Keywords: Astronomy
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  • 63
    Publication Date: 2019-07-19
    Description: After one year of survey observations and more than 70 billion triggers, Fermi is revealing an unprecedented view of the high energy gamma-ray sky. The observatory carries two instruments, the Gamma-ray Burst Monitor (GBM, 8 keV - 40 MeV) and the Large Area Telescope (LAT, 20 MeV - X300 GeV), which in combination cover over 7 orders of magnitude in energy. The LAT provides substantially more sensitivity than previous instruments in this waveband and has opened up the energy window from 10-100 GeV. This is particularly relevant for the study of gamma-ray sources in the Galaxy. The first year data have revealed new classes of Galactic emitters as well as providing spectacular detail on some old friends. I'll review the fascinating range of Galactic emission now seen - from pulsars their nebulae to X-ray binaries and supernova remnants - with particular emphasis on the impact of the Fermi pulsars.
    Keywords: Astronomy
    Type: A First Year View of the Galaxy with the Fermi Gamma-ray Space Telescope; Sep 28, 2009 - Sep 30, 2009; Montreal; Canada
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  • 64
    Publication Date: 2019-07-19
    Description: Enceladus has taken its place as one of the most remarkable moons in the solar system. When Voyager encountered Enceladus it was noted that its surface showed signs of recent activity with the observations of a large province, which was characterized by smooth sparsely cratered terrain. Even the heavily cratered areas of Enceladus showed a lower crater density than other Saturnian satellites. Moreover, its extraordinarily high albedo hinted at past cryovolcanic resurfacing events. Ground-based observations further demonstrated that Saturn's diffuse E-ring is concentrated at the orbit of EnceladLis, making the moon, the likely source of E-ring particles. However the short estimated lifetime of E-ring particles requires that new particles must constantly be fed to the Ering, implying more recent activity on Enceladus. Recently, in 2005 the Cassini spacecraft provided definitive proof that Enceladus is currently geologically active when multiple Cassini instruments detected plumes of gas and ice particles emanating from a series of warm fractures centered on the south pole, dubbed the "tiger stripes." Enceladus is the second cryovolcanically active icy satellite that has been identified (Triton is the only other known active icy satellite) and can be used to study active processes that are thought to have once played a role in shaping the surfaces of other icy satellites. These processes include tidal heating, cryovolcanism, and ice tectonism, which all can be studied as they currently happen on Enceladus, Moreover, the plume source region on Enceladus samples a warm, chemically rich, environment that may facilitate complex organic chemistry and biological processes. For these reasons, Enceladus science is highly relevant to NASA's goals.
    Keywords: Astronomy
    Type: 41st annual meeting of the Division of Planetary Sciences of the American Astronomical Society; Oct 04, 2009 - Oct 10, 2009; Fajardo; Puerto Rico
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  • 65
    Publication Date: 2019-07-19
    Description: Given the non-spherical shape of Enceladus, the satellite may experience gravitational torques that will cause it to physically librate as it orbits Saturn. Physical Libration would produce a diurnal oscillation in the longitude of Enceladus' tidal bulge, which could have a profound effect on the diurnal stresses experienced by the surface of the satellite. Although Cassini ISS has placed an observational upper limit on Enceladus' libration amplitude, small amplitude librations may have geologically significant consequences. For example, a physical libration will affect heat production. along the tiger stripes as produced by tidal shear heating. We have modeled the expected power en-litted along the tiger stripes for various types of physical libration and have quantified which types of physical libration best reproduce the observed power flux as detailed in Cassini CIRS data. We find that including a physical libration does allow better fits to the observations and we have identified regions of the libration phase space that where these fits are optimized. A physical libration has important implications for tidal dissipation within Enceladus and if identified may provide an additional constraint on its interior mass distribution.
    Keywords: Astronomy
    Type: 41st annual meeting of the Division for Planetary Sciences of the American Astronomical Society; Oct 04, 2009 - Oct 10, 2009; Fajardo; Puerto Rico
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  • 66
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    Publication Date: 2019-07-19
    Description: A brief historical introduction to the development of observational astronomy will be presented. The close historical relationship between the successful application of mathematical concepts and advances in astronomy will be presented. A variety of simple physical demonstrations, hands-on group activities, and puzzles will be used to understand how the properties of light can be used to understand the contents of our universe.
    Keywords: Astronomy
    Type: National Radio Astronomy Observatory Conference; Jan 30, 2009 - Jan 31, 2009; Martinsville, WV; United States
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  • 67
    Publication Date: 2019-07-19
    Description: An interesting new high-energy pulsar sub-population is emerging following early discoveries of gamma-ray millisecond pulsars (MSPs) by the Fermi Large Area Telescope (LAT). We present results from 3D emission modeling, including the Special Relativistic effects of aberration and time-of-flight delays and also rotational sweepback of 13-field lines, in the geometric context of polar cap (PC), slot gap (SG), outer gap (OG), and two-pole caustic (TPC) pulsar models. In contrast to the general belief that these very old, rapidly-rotating neutron stars (NSs) should have largely pair-starved magnetospheres due to the absence of significant pair production, we find that most of the light curves are best fit by SG and OG models, which indicates the presence of narrow accelerating gaps limited by robust pair production -- even in these pulsars with very low spin-down luminosities. The gamma-ray pulse shapes and relative phase lags with respect to the radio pulses point to high-altitude emission being dominant for all geometries. We also find exclusive differentiation of the current gamma-ray MSP population into two MSP sub-classes: light curve shapes and lags across wavebands impose either pair-starved PC (PSPC) or SG / OG-type geometries. In the first case, the radio pulse has a small lag with respect to the single gamma-ray pulse, while the (first) gamma-ray peak usually trails the radio by a large phase offset in the latter case. Finally, we find that the flux correction factor as a function of magnetic inclination and observer angles is typically of order unity for all models. Our calculation of light curves and flux correction factor f(_, _, P) for the case of MSPs is therefore complementary to the "ATLAS paper" of Watters et al. for younger pulsars.
    Keywords: Astronomy
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  • 68
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    In:  Other Sources
    Publication Date: 2019-07-19
    Description: Prior to the launch of Fermi, only weak gamma-ray pulsations from a single millisecond pulsar, PSR J0218+4232, had been reported. A firm detection of gamma rays from a member of this class of pulsar having periods near neutron star break-up and magnetic dipole moments well below those of normal pulsars would provide new insights into pulsar acceleration and emission. Using accurate ephemerides obtained from several radio telescopes as well as the unprecedented accuracy of the GPS-derived clocks used by Fermi and the LAT, we have searched for gamma-ray pulsations from known pulsars over a broad range of timing parameters. We will present some results from our search for pulsed gamma rays from millisecond pulsars.
    Keywords: Astronomy
    Type: 213th American Astronomical Society Meeting; Jan 04, 2009 - Jan 08, 2009; California; United States
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  • 69
    Publication Date: 2019-07-19
    Description: Although elder self-neglect is the most common form of elder mistreatment, its pathophysiology is not well understood. Alpha-tocopherol is a lipid soluble antioxidant required for the preservation of cell membranes. Since the association between tocopherol and cognitive impairment in older adults has been described, we explored the possibility of its role in elder self-neglect. OBJECTIVE: (1) To determine whether serum tocopherol levels are associated with elder self-neglect, and (2) to assess the association of serum tocopherol levels and cognitive function in elder self-neglect. METHODS: Serum tocopherol levels were measured in a cohort of 67 self-neglecting elders and 67 matched controls, recruited for the Consortium for Research in Elder Self-neglect of Texas. Pearson s correlation tests were performed to assess bivariate associations between serum tocopherol levels and cognitive function. RESULTS: Mean serum alpha-tocopherol levels were 10.8 +/- 4.7 ug/mL in self-neglect group and 13.0 +/- 4.9 ug/mL in control group (p = 0.006, unpaired student s t-test). None of the participants from either group had alpha-tocopherol level lower than the reference range. Mean serum gamma-tocopherol levels were 2.0 +/- 1.0 ug/mL in self-neglect group and 2.0 +/- 1.1 in control group (p=0.83). Proportion of the elders with gamma-tocopherol level lower than the reference range were 4.5% (3/66) in self-neglect group and 10.4% (7/67) in control group (p=0.32, Fisher s Exact Test). Among the self-neglecting elders, no association was found between serum alpha-tocopherol levels and the Mini-Mental State Examination (MMSE) or the Wolf-Klein Clock Drawing Test (CDT) scores (r =-0.42, p=0.75 for MMSE; r=0.08, p=0.54 for CDT). No association was found between serum gamma-tocopherol levels and the MMSE or the CDT (r=-0.12, p=0.35 for MMSE; r=0.05, p=0.68 for CDT). CONCLUSION: In our sample, neither alpha-tocopherol nor gamma-tocopherol appears to have a role in pathophysiology of elder self-neglect. Nevertheless, significantly lower serum alpha-tocopherol levels in the self neglect group merits further research.
    Keywords: Life Sciences (General)
    Type: American Geriatrics Society Annual Meeting; Apr 29, 2009 - May 03, 2009; Chicago, IL; United States
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  • 70
    Publication Date: 2019-07-19
    Description: The delivery of amino acids to the early Earth by comets and their fragments could have been a significant source of the early Earth's prebiotic organic inventory that led to the emergence of life (Chyba and Sagan, 1992). Over 20 organic molecules including methane, ethane, ammonia, cyanic acid, formaldehyde, formamide, acetaldehyde, acetonitrile, and methanol have been identified by radio spectroscopic observations of the comae of comets Hale-Bopp and Hyakutake (Crovisier et al. 2004). These simple molecules could have provided the organic reservoir to allow the formation of more complex prebiotic organic compounds such as amino acids. After a 7-year mission, the Stardust spacecraft returned to Earth samples from comet Wild 2 on January 15, 2006 providing the opportunity to analyze the organic composition and isotopic distribution of cometary material with state-of-the-art laboratory instrumentation. The Preliminary Examination Team analyses of organics in samples returned by Stardust were largely focused on particles that impacted the collector aerogel and aluminum foil (Sandford et al. 2006). However, it is also possible that Stardust returned a "diffuse" sample of gas-phase organic molecules that struck the aerogel directly or diffused away from the grains after impact. To test this possibility, samples of Stardust flight aerogel and foil were carried through a hot water extraction and acid hydrolysis procedure to see if primary amine compounds were present in excess of those seen in controls. Here we report highly sensitive liquid chromatography time-of-flight mass spectrometry measurements of amino acids and amines in samples returned from a comet (Glavin et al. 2008). A suite of amino acids and amines including glycine, L-alanine, methylamine (MA), and ethylamine (EA) were identified in the Stardust bulk aerogel. With the exception of MA and EA, all other primary amines detected in comet-exposed aerogels were also present in the aerogel witness tile that was not exposed to Wild 2, suggesting that most amines are terrestrial in origin. However, the enhanced abundances of MA, EA, and possibly glycine in comet-exposed aerogel compared to controls, coupled with MA to EA ratios (1 to 2) that are distinct from preflight aerogels (7 to 10), suggest that these amines were captured from Wild 2. It is possible that MA and EA were formed on energetically processed icy grains containing methane, ethane, and ammonia. The presence of cometary amines in Stardust material supports the hypothesis that comets were an important source of prebiotic organics on the early Earth. To better understand their origin, a systematic compound specific carbon isotopic analysis (C-CSIA) via gas chromatography quadrupole mass spectrometry in with parallel with combustion isotope ratio mass spectrometry (GCQMS/ IRMS) is being conducted. We will discuss our latest C-CSIA measurements and what they indicate about the origin of amino acids extracted from Stardust samples.
    Keywords: Astronomy
    Type: Origins of Life and Evolution of the Biosphere; 39; 179-392
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  • 71
    Publication Date: 2019-07-19
    Description: Astronomical studies at infrared wavelengths have dramatically improved our understanding of the universe, and observations with Spitzer, the upcoming Herschel mission, and SOFIA will continue to provide exciting new discoveries. The relatively low angular resolution of these missions, however, is insufficient to resolve the physical scale on which mid-to far-infrared emission arises, resulting in source and structure ambiguities that limit our ability to answer key science questions. Interferometry enables high angular resolution at these wavelengths - a powerful tool for scientific discovery. We will build the Balloon Experimental Twin Telescope for Infrared Interferometry (BETTII), an eight-meter baseline Michelson stellar interferometer to fly on a high-altitude balloon. BETTII's spectral-spatial capability, provided by an instrument using double-Fourier techniques, will address key questions about the nature of disks in young star clusters and active galactic nuclei and the envelopes of evolved stars. BETTII will also lay the technological groundwork for future space interferometers and for suborbital programs optimized for studying extrasolar planets.
    Keywords: Astronomy
    Type: Pathways Towards Habitable Planets; Aug 14, 2009 - Aug 18, 2009; Barcelona; Spain
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  • 72
    Publication Date: 2019-07-19
    Description: The radioadaptive response is a phenomenon where exposure to a prior low dose of radiation reduces the level of damage induced by a subsequent high radiation dose. The molecular mechanism behind this is still not well understood. Learning more about the radioadaptive response is critical for long duration spaceflight since astronauts are exposed to low levels of cosmic radiation. The micronucleus assay was used to measure the level of damage caused by radiation. Although cells which were not washed with phosphate buffered saline (PBS) after a low priming dose of 5cGy did not show adaptation to the challenge dose, washing the cells with PBS and giving the cells fresh media after the low dose did allow radioadaptation to occur. This is consistent with the results of a previous publication by another research group. In the present study, genes involved in DNA damage signaling and the oxidative stress response were studied using RT PCR techniques in order to look at changes in expression level after the low dose with or without washing. Our preliminary results indicate that upregulation of oxidative stress response genes ANGPTL7, NCF2, TTN, and SRXN1 may be involved in the radioadaptive response. The low dose of radiation alone was found to activate the oxidative stress response genes GPR156 and MTL5, whereas, washing the cells alone caused relatively robust upregulation of the oxidative stress response genes DUSP1 and PTGS2. Washing after the priming dose showed some changes in the expression level of several DNA damage signaling genes. In addition, we studied whether washing the cells after the priming dose has an effect on the level of nitric oxide in both the media and cells, since nitric oxide levels are known to increase in the media of the cells after a high dose of radiation only if the cells were already exposed to a low priming dose. Based on this preliminary study, we propose that washing the cells after priming exposure actually eliminates some factor secreted by the cells that inhibits radioadaptation leading to the upregulation of some genes which initiates the response.
    Keywords: Life Sciences (General)
    Type: JSC-CN-18807 , SK Student Presentations; Aug 28, 2009; Houston, TX; United States
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  • 73
    Publication Date: 2019-07-19
    Description: Deterministic pathway models that describe the biochemical interactions of a group of related proteins, their complexes, activation through kinase, etc. are often the basis for many systems biology models. Low dose radiation effects present a unique set of challenges to these models including the importance of stochastic effects due to the nature of radiation tracks and small number of molecules activated, and the search for infrequent events that contribute to cancer risks. We have been studying models of the ATM, TGF -Smad and WNT signaling pathways with the goal of applying pathway models to the investigation of low dose radiation cancer risks. Modeling challenges include introduction of stochastic models of radiation tracks, their relationships to more than one substrate species that perturb pathways, and the identification of a representative set of enzymes that act on the dominant substrates. Because several pathways are activated concurrently by radiation the development of modular pathway approach is of interest.
    Keywords: Life Sciences (General)
    Type: JSC-18076 , Low Dose Workshop; Apr 06, 2009; Bethesda, MD; United States
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  • 74
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    In:  Other Sources
    Publication Date: 2019-07-19
    Description: The Primordial Inflation Polarization Explorer is a balloon-borne instrument to measure the polarization of the cosmic microwave background in order to detect the characteristic signature of gravity waves created during an inflationary epoch in the early universe. PIPER combines cold /I.G K\ optics, 5120 bolometric detectors, and rapid polarization modulation using VPM grids to achieve both high sensitivity and excellent control of systematic errors. I will discuss the current status and plans for the PIPER instrument.
    Keywords: Astronomy
    Type: The Path to CMBPol: Upcoming Measurements of CMB Polarization; Jul 01, 2009 - Jul 03, 2009; Chicago, IL; United States
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  • 75
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    Publication Date: 2019-07-19
    Description: In addition to probing inflationary cosmology, PIPER will measure the polarized dust emission from the Galaxy. PIPER will be capable of full (I,0,U,V) measurement over four frequency bands ' These measurements will provide insight into the physics of dust grains and a probe of the Galactic magnetic field on large and intermediate scales.
    Keywords: Astronomy
    Type: The Path to CMBP0l: Upcoming Measurements of DMB Polarizaiton; Jul 01, 2009 - Jul 03, 2009; Chicago, IL; United States
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  • 76
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    Publication Date: 2019-07-19
    Description: We report on a study of approx.20,000 luminous red galaxies (LRG's) at z=0.4-0.5 observed by the Sloan Digital Sky Survey. In order to differentiate among them, we measured restframe magnitudes, u (3000-3500 A), b (4200-4800 A), and y (5700-6300 A) from the spectra themselves. The galaxies show a significant range in restframe colors and absolute magnitudes. We binned the spectra according to the restframe u-b color and y-band absolute magnitude in order to increase the S/N. We used 3 approaches to estimate the ages and metal content of these binned spectra: via their spectral energy distributions, from spectral-line indices, and by full spectral fitting. The three methods usually produce discordant results
    Keywords: Astronomy
    Type: VIIth Marseille International Cosmology Conference. Harvesting the Desert: The Universe between Redshift 1 and 3; Jun 29, 2009 - Jul 03, 2009; Marseille; France|International Astronomical Union (IAU) XXVII; Aug 03, 2009 - Aug 14, 2009; Rio de Janeiro; Brazil|Bridging Laboratory and Astrophysics: From the Infrared to the Submm; Jun 08, 2009 - Jun 10, 2009; Pasadena, CA; United States
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  • 77
    Publication Date: 2019-07-19
    Description: Recently the Advanced Thin Ionization Calorimeter (ATIC) balloon experiment reported observations of high energy cosmic ray electrons over the energy range 300 to 800 GeV, indicating a feature or "bump" in the otherwise smoothly decreasing energy spectrum. The severe energy losses that occur as these high energy particles traverse the galaxy render the cosmic ray electron spectrum sensitive to local (a few kiloparsecs) sources and hence very interesting. The ATIC results are the first time that such a cosmic ray spectrum anomaly has been observed at high energy. Potential sources of this electron excess include pulsars, microquasars, supernovae remnants as well as the annihilation of exotic dark matter candidate particles. ATIC has had three successful high altitude flights over the continent of Antarctica 2000-2001, 2002-2003 and 2007-2008. Only results from the first two flights have been reported so far. During this talk we will discuss the ATIC experiment, the electron observations (including preliminary results from the most recent ATIC flight), examine the merits of the various source models and compare the ATIC observations with other recent measurements.
    Keywords: Astronomy
    Type: M09-0288 , April meeting of the APS; May 02, 2009 - May 05, 2009; Denver, CO; United States
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  • 78
    Publication Date: 2019-07-19
    Description: The Ku70/80 heterodimer is the first repair protein in the initial binding of double-strand break (DSB) ends following DNA damage, and is a component of nonhomologous end joining repair, the primary pathway for DSB repair in mammalian cells. In this study we constructed a full-length human Ku70 structure based on its crystal structure, and performed 20 ns conventional molecular dynamic (CMD) simulations on this protein and several other complexes with short DNA duplexes of different sequences. The trajectories of these simulations indicated that, without the topological support of Ku80, the residues in the bridge and C-terminal arm of Ku70 are more flexible than other experimentally identified domains. We studied the two missing loops in the crystal structure and predicted that they are also very flexible. Simulations revealed that they make an important contribution to the Ku70 interaction with DNA. Dislocation of the previously studied SAP domain was observed in several systems, implying its role in DNA binding. Targeted molecular dynamic (TMD) simulation was also performed for one system with a far-away 14bp DNA duplex. The TMD trajectory and energetic analysis disclosed detailed interactions of the DNA-binding residues during the DNA dislocation, and revealed a possible conformational transition for a DSB end when encountering Ku70 in solution. Compared to experimentally based analysis, this study identified more detailed interactions between DNA and Ku70. Free energy analysis indicated Ku70 alone is able to bind DNA with relatively high affinity, with consistent contributions from various domains of Ku70 in different systems. The functional implications of these domains in the processes of Ku heterodimerization and DNA damage recognition and repair can be characterized in detail based upon this analysis.
    Keywords: Life Sciences (General)
    Type: JSC-CN-19108 , 15th International Symposium on Microdosimetry; Oct 25, 2009 - Oct 30, 2009; Verona; Italy
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  • 79
    Publication Date: 2019-07-19
    Description: Chromosome aberration yields were assessed in DNA double-strand break repair (DSB) deficient cells after acute doses of gamma-rays or high-LET iron nuclei, or low dose-rate (0.018 Gy/hr) gamma-rays. We studied several cell lines including fibroblasts deficient in ATM (product of the gene that is mutated in ataxia telangiectasia patients) or NBS (product of the gene mutated in the Nijmegen breakage syndrome), and gliomablastoma cells that are proficient or lacking in DNA-dependent protein kinase, DNA-PK activity. Chromosomes were analyzed using the fluorescence in-situ hybridization (FISH) chromosome painting method in cells at the first division post-irradiation and chromosome aberrations were identified as either simple exchanges (translocations and dicentrics) or complex exchanges (involving 〉2 breaks in 2 or more chromosomes). Gamma radiation induced higher yields of both simple and complex exchanges in the DSB repair defective cells than in the normal cells. The quadratic dose-response terms for both chromosome exchange types were significantly higher for the ATM and NBS defective lines than for normal fibroblasts. However, the linear dose-response term was significantly higher only for simple exchanges in the NBS cells. Large increases in the quadratic dose response terms indicate the important roles of ATM and NBS in chromatin modifications that facilitate correct DSB repair and minimize aberration formation. Differences in the response of AT and NBS deficient cells at lower doses suggests important questions about the applicability of observations of radiation sensitivity at high dose to low dose exposures. For all iron nuclei irradiated cells, regression models preferred purely linear and quadratic dose responses for simple and complex exchanges, respectively. All the DNA repair defective cell lines had lower Relative biological effectiveness (RBE) values than normal cells, the lowest being for the DNA-PK-deficient cells, which was near unity. To further investigate the sensitivity differences for low and low high doses, we performed chronic low dose-rate irradiation, and have begun studies with ATM and Nibrin inhibitors and siRNA knockout of these proteins. Results support the conclusion that for the endpoint of simple chromosomal aberrations (translocation or dicentrics), the increased radiation sensitivity of AT cells found at high doses (〉1 Gy) does not carry over to low doses or doserates, while NBS cells show increased sensitivity for both high and low dose exposures.
    Keywords: Life Sciences (General)
    Type: JSC-18081 , Radiation Research Society 55th Annual Meeting; Oct 04, 2009 - Oct 07, 2009; Savannah, GA; United States
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  • 80
    Publication Date: 2019-07-19
    Description: Physical effort, compensation, and controllability in a spacesuit can be affected by suit mass and gravity level. Because of limitations in certain reduced-gravity simulators and the finite selection of lunar prototype suits, it is difficult to ascertain how a change in suit mass affects suited human performance. One method of simulating a change in mass is to vary the total gravity-adjusted weight (TGAW), which is defined as the sum of the suit mass and subject mass, multiplied by the gravity level. PURPOSE: To determine if two methods of changing TGAW during parabolic flight - changing suit mass or gravity level - affect subjective ratings of suited human performance equally. METHODS: A custom weight support structure was connected to a lunar prototype spacesuit, allowing the addition of mass to the suit while maintaining a near-constant center of mass. In the varied-weight (VW) series, suit mass (120 kg) was constant at 0.1 G, 0.17 G, and 0.3 G, yielding TGAWs of 196, 333, and 588 N, assuming an 80-kg subject. In the varied-mass (VM) series, gravity level was constant at 0.17 G and suit mass was 89, 120, and 181 kg, yielding TGAWs of 282, 333, and 435 N. The 333 N condition was common to both series. Direct comparison was not possible due to limited adjustability of suit mass and limited options for parabolic profiles. Five astronaut subjects (80.3 11.8 kg) completed 4 different tasks (walk, bag pickup, lunge, and shoveling) in all conditions and provided ratings of perceived exertion (RPE) and the gravity compensation and performance scale (GCPS) upon completion of each task. RESULTS: Where VM and VW series overlapped, RPE and GCPS trendlines were similar. Mean RPE and GCPS at 333 N was 8.4 and 3.7. Mean RPE and GCPS for VM was 7.8 and 3.8 for 282 N and 9.8 and 4.1 for 435 N. Extrapolation of the VM trend to match VW TGAWs 196 and 588 N predicts an RPE of 6.5 and 12.3 and GCPS of 4.4 and 5.9, whereas the measured VW values for RPE were 8.1 and 9.8 and GCPS were 4.4 and 3.7. CONCLUSION: Modeling a change in suit mass by altering weight alone may be an adequate simulation through a limited range when looking at gross metrics of subjective suited human performance. Whether altering weight alone will be sufficient for more precise metrics of human performance, and across a wider range of activities, still needs further study.
    Keywords: Life Sciences (General)
    Type: JSC-CN-19240 , American College of Sports Medicine (ACSM); Jun 02, 2010 - Jun 05, 2010; Baltimore, MD; United States
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  • 81
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    Publication Date: 2019-07-19
    Description: The risk of infectious disease to select individuals has historically been difficult to predict in either spaceflight or on Earth with health care efforts relying on broad-based prevention and post-infection treatment. Over the past 10 years, quantitative microbial risk assessment evaluations have evolved to formalize the assessment process and quantify the risk. This process of hazard identification, exposure assessment, dose-response assessment, and risk characterization has been applied by the water and food safety industries to address the public health impacts associated with the occurrence of and human exposure to pathogens in water and food for the development of preventive strategies for microbial disease. NASA is currently investigating the feasibility of using these techniques to better understand the risks to astronauts and refine their microbiological requirements. To assess these techniques, NASA began an evaluation of the potable water system on the International Space Station to determine how the microbial risk from water consumption during flight differed from terrestrial sources, such as municipal water systems. The ultimate goal of this work is to optimize microbial requirements which would minimize unnecessary cargo and use of crew time, while still protecting the health of the crew. Successful demonstration of this risk assessment framework with the water system holds the potential to maximize the use of available resources during spaceflight missions and facilitate investigations into the evaluation of other routes of infection, such as through the spaceflight foods system.
    Keywords: Life Sciences (General)
    Type: JSC-CN-19085 , Aerospace Medicine Association Meeting; May 09, 2010 - May 13, 2010; Phoenix, AZ; United States
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  • 82
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    Publication Date: 2019-07-19
    Description: The Fermi Gamma-ray Space Telescope, formerly called GLAST, is a mission to measure the cosmic gamma-ray flux in the energy range 20 MeV to more than 300 GeV, with supporting measurements for gamma-ray bursts from 8 keV to 30 MeV. In addition to breakthrough capabilities in energy coverage and localization, the very large field of view enables observations of 20% of the sky at any instant, and the entire sky on a timescale of a few hours. With its recent launch on 11 June 2008, Fermi now opens a new and important window on a wide variety of phenomena, including pulsars, black holes and active galactic nuclei, gamma-ray bursts, the origin of cosmic rays and supernova remnants, and searches for hypothetical new phenomena such as supersymmetric dark matter annihilations. In addition to early results and the science opportunities, this talk includes a description of the instruments and the mission status and plans.
    Keywords: Astronomy
    Type: 213th Meeting of the American Astronomical Society with HAD and HEAD; Jan 04, 2009 - Jan 08, 2009; California; United States
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  • 83
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    Publication Date: 2019-07-19
    Description: Astronomical studies at infrared wavelengths have dramatically improved our understanding of the universe, and observations with Spitzer, Herschel, and SOFIA will continue to provide exciting new discoveries. The relatively low angular resolution of these missions, however, is insufficient to resolve the physical scale on which mid-to far-infrared emission arises, resulting in source and structure ambiguities that limit our ability to answer key science questions. Interferometry enables high angular resolution at these wavelengths - a powerful tool for scientific discovery. We will build the Balloon Experimental Twin Telescope for Infrared Interferometry (BETTII), an eight-meter baseline Michelson stellar interferometer to fly on a high-altitude balloon. BETTII's spectral-spatial capability, provided by an instrument using double-Fourier techniques, will address key questions about the nature of disks in young star clusters and active galactic nuclei and the envelopes of evolved stars. BETTII will also lay the technological groundwork for future balloon programs, paving the way for interferometric observations of exoplanets.
    Keywords: Astronomy
    Type: Low Cost Access to Near Space 2009; Oct 25, 2009 - Oct 28, 2009; Boulder, CO; United States
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  • 84
    Publication Date: 2019-07-19
    Description: Direct infrared imaging and spectroscopy of exoplanets will allow for detailed characterization of the atmospheric constituents of more than 200 nearby Earth-like planets, more than is possible with any other method under consideration. A flagship mission based on larger passively cooled infrared telescopes and formation flying technologies would have the highest angular resolution of any concept under consideration. The 2008 Exoplanet Forum committee on Direct Infrared Imaging of Exoplanets recommends: (1) a vigorous technology program including component development, integrated testbeds, and end-to-end modeling in the areas of formation flying and mid-infrared nulling; (2) a probe-scale mission based on a passively cooled structurally connected interferometer to be started within the next two to five years, for exoplanetary system characterization that is not accessible from the ground, and which would provide transformative science and lay the engineering groundwork for the flagship mission with formation flying elements. Such a mission would enable a complete exozodiacal dust survey (〈1 solar system zodi) in the habitable zone of all nearby stars. This information will allow for a more efficient strategy of spectral characterization of Earth-sized planets for the flagship missions, and also will allow for optimization of the search strategy of an astrometric mission if such a mission were delayed due to cost or technology reasons. (3) Both the flagship and probe missions should be pursued with international partners if possible. Fruitful collaboration with international partners on mission concepts and relevant technology should be continued. (4) Research and Analysis (R&A) should be supported for the development of preliminary science and mission designs. Ongoing efforts to characterize the the typical level of exozodiacal light around Sun-like stars with ground-based nulling technology should be continued.
    Keywords: Astronomy
    Type: Missions for Exoplanets 2010-2020; Apr 20, 2009 - Apr 24, 2009; Pasadena, CA; United States
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  • 85
    Publication Date: 2019-07-19
    Description: Dust coming from asteroids and comets will strongly affect direct imaging and characterization of terrestrial planets in the Habitable Zones of nearby stars. Such dust in the Solar System is called the zodiacal dust (or 'zodi' for short). Higher levels of similar dust are seen around many nearby stars, confined in disks called debris disks. Future high-contrast images of an Earth-like exoplanet will very likely be background-limited by light scattered of both the local Solar System zodi and the circumstellar dust in the extrasolar system (the exozodiacal dust). Clumps in the exozodiacal dust, which are expected in planet-hosting systems, may also be a source of confusion. Here we discuss the problems associated with imaging an Earth-like planet in the presence of unknown levels of exozodiacal dust. Basic formulae for the exoplanet imaging exposure time as function of star, exoplanet, zodi, exozodi, and telescope parameters will be presented. To examine the behavior of these formulae, we apply them to the New Worlds Observer (NWO) mission. NWO is a proposed 4-meter UV/optical/near-IR telescope, with a free flying starshade to suppress the light from a nearby star and achieve the high contrast needed for detection and characterization of a terrestrial planet in the star's Habitable Zone. We find that NWO can accomplish its science goals even if exozodiacal dust levels are typically much higher than the Solar System zodi level. Finally, we highlight a few additional problems relating to exozodiacal dust that have yet to be solved.
    Keywords: Astronomy
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  • 86
    Publication Date: 2019-07-19
    Description: The International X-ray Observatory requires mirror assemblies with unprecedented characteristics that cannot be provided by existing optical technologies. In the past several years, the project has supported a vigorous mirror technology development program. This program includes the fabrication of lightweight mirror segments by slumping commercially available thin glass sheets, the support and mounting of these thin mirror segments for accurate metrology, the mounting and attachment of these mirror segments for the purpose of X-ray tests, and development of methods for aligning and integrating these mirror segments into mirror assemblies. This paper describes our efforts and developments in these areas.
    Keywords: Astronomy
    Type: 213th Meeting of the American Astronomical Society; Jan 04, 2009 - Jan 09, 2009; Long Beach, CA; United States
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  • 87
    Publication Date: 2019-07-19
    Description: The one repetition maximum (1RM) is a criterion measure of muscle strength. However, the reliability of 1RM testing in novice subjects has received little attention. Understanding this information is crucial to accurately interpret changes in muscle strength. To evaluate the test-retest reliability of a squat (SQ), heel raise (HR), and deadlift (DL) 1RM in novice subjects. Twenty healthy males (31 plus or minus 5 y, 179.1 plus or minus 6.1 cm, 81.4 plus or minus 10.6 kg) with no weight training experience in the previous six months participated in four 1RM testing sessions, with each session separated by 5-7 days. SQ and HR 1RM were conducted using a smith machine; DL 1RM was assessed using free weights. Session 1 was considered a familiarization and was not included in the statistical analyses. Repeated measures analysis of variance with Tukey fs post-hoc tests were used to detect between-session differences in 1RM (p.0.05). Test-retest reliability was evaluated by intraclass correlation coefficients (ICC). During Session 2, the SQ and DL 1RM (SQ: 90.2 }4.3, DL: 75.9 }3.3 kg) were less than Session 3 (SQ: 95.3 }4.1, DL: 81.5 plus or minus 3.5 kg) and Session 4 (SQ: 96.6 }4.0, DL: 82.4 }3.9 kg), but there were no differences between Session 3 and Session 4. HR 1RM measured during Session 2 (150.1 }3.7 kg) and Session 3 (152.5 }3.9 kg) were not different from one another, but both were less than Session 4 (157.5 }3.8 kg). The reliability (ICC) of 1RM measures for Sessions 2-4 were 0.88, 0.83, and 0.87, for SQ, HR, and DL, respectively. When considering only Sessions 3 and 4, the reliability was 0.93, 0.91, and 0.86 for SQ, HR, and DL, respectively. One familiarization session and 2 test sessions (for SQ and DL) were required to obtain excellent reliability (ICC greater than or equal to 0.90) in 1RM values with novice subjects. We were unable to attain this level of reliability following 3 HR testing sessions therefore additional sessions may be required to obtain an ICC of greater than or equal to 0.90. Future resistive exercise studies should consider the reliability of specific measures to ensure that changes in strength with training are attributable to training and not learning effects associated with 1RM testing.
    Keywords: Life Sciences (General)
    Type: 56th Annual Meeting of the American College of Sports Medicine; May 27, 2009 - May 30, 2009; Seattle, WA; United States
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  • 88
    facet.materialart.
    Unknown
    In:  Other Sources
    Publication Date: 2019-07-19
    Description: Space Life Sciences Directorate (SLSD) specializes in transitioning technology and knowledge to medical operations. This activity encompasses funding a spectrum of research and technology efforts, such as understanding fundamental biological mechanisms altered by microgravity and executing technology watches for state of the art diagnostic imaging equipment. This broad spectrum approach to fulfilling the need to protect crewmember health and performance during long and short duration missions to the International Space Station, moon and Mars is made possible by having a line of site between research and operations. Currently, SLSD's line of site is articulated in a transition to medical practice (TMP) process. This process is designed to shepherd information and knowledge gained through fundamental and mechanistic research toward the development of an operational solution such as a pre-flight selection criteria; an in-flight countermeasure, monitoring capability or treatment; or a post-flight reconditioning program. The TMP process is also designed to assist with the customization of mature hardware or technology for NASA specific use. The benefits of this process are that the concept of operational usability is interjected early in the research, design, or acquisition phase, and stakeholders are involved early to identify requirements and also periodically asked to assess requirements compliance of research or technology development project. Currently a device known as the actiwatch is being assessed for the final transition to operational use. Specific examples of research to operations transition success help to illustrate the process and bolster communication between the research and medical operations communities.
    Keywords: Life Sciences (General)
    Type: Annual Meeting of the Aerospace Medical Society; May 03, 2009 - May 07, 2009; Los Angeles, CA; United States
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  • 89
    Publication Date: 2019-07-19
    Description: We have resolved the outer structures of the massive binary interacting wind of Eta Carinae using the HST/STIS. They extend as much as 0.7' (1600AU) and are highly distorted due to the very elliptical orbit of the binary system. Observations conducted from 1998.0 to 2004.3 show spatial and temporal variations consistent with a massive, low excitation wind, seen by spatially resolved, velocity-broadened [Fe II], and a high excitation extended wind interaction region, seen by[Fe III], in the shape of a distorted paraboloid. The highly excited [Fe III] structure is visible for 90% of the 5.5-year period, but disappears as periastron occurs along with the drop of X-Rays as seen by RXTE. Some components appear in [Fe II] emission across the months long minimum. We will discuss the apparent differences between the bowshock orientation derived from the RXTE light curve and these structures seen by HST/STIS. Monitoring the temporal variations with phase using high spatial resolution with appropriate spectral dispersions proves to be a valuable tool for understanding massive wind interactions.
    Keywords: Astronomy
    Type: 213th Meeting of the American Astronomical Society with HAD and HEAD: 2009 International Year of Astronomy; Jan 04, 2009 - Jan 08, 2009; Long Beach, CA; United States
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  • 90
    Publication Date: 2019-07-19
    Description: Space-based astronomy is going through a renaissance, with three Great Observatories currently flying: Hubble in the visible and ultraviolet, Spitzer in the infrared and Chandra in X-rays. The future looks equally bright. The final servicing mission to Hubble will take place in February 2009 and promises to make the observatory more capable than ever with two new cameras, and refurbishment that will allow it to last at least five years. The upcoming launch of the Herschel Space Telescope will open the far-infrared to explore the cool and dusty Universe. Finally, we look forward to the launch of the James Webb Space Telescope in 2013, which wil provide a successor to both Hubble and Spitzer. In this talk, the author discusses some of the highlights of scientific discovery in the last 10 years and reveals the promise to the next 10 years.
    Keywords: Astronomy
    Type: Opening Ceremonies of the 2009 International Year of Astronomy; Jan 13, 2009 - Jan 17, 2009; Paris; France
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  • 91
    Publication Date: 2019-07-19
    Description: The scientific capabilities of the James Webb Space Telescope fall into four themes. The End of the Dark Ages: First Light and Reionization theme seeks to identify the first luminous sources to form and to determine the ionization history of the universe. The Assembly of Galaxies theme seeks to determine how galaxies and dark matter, gas, stars, metals morphological structures, and active nuclei within them evolved from the epoch of reionization to the present. The Birth of Stars and Protoplanetary Systems and the Origins of Life theme seeks to determine the physical and chemical properties of planetary systems around nearby stars and of our own, and investigate the potential for life in those systems. A comprehensive, top-level review of JWST sciences was published in the journal Space Science Reviews (Gardner et al. 2006, SSR, 123, 485). That paper gives details of the 4 JWST science themes, and describes the design of the observatory and ground system. Since that paper was published, the JWST Science Working Group, working with members of the astronomical community, has continued to develop the science case for JWST, giving more details in a series of white papers. In this poster, the main science themes and white papers are reviewed.
    Keywords: Astronomy
    Type: 213th Meetin gof the American Astronomical Society with HAD and HEAD; Jan 04, 2008 - Jan 08, 2008; Long Beach, CA; United States
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  • 92
    facet.materialart.
    Unknown
    In:  Other Sources
    Publication Date: 2019-07-19
    Description: The James Webb Space Telescope (JWST) is a large aperture (6.5 meter), cryogenic space telescope with a suite of near and mid-infrared instruments covering the wavelength range of 0.6 pm to 28 pm. JWST's primary science goal is to detect and characterize the first galaxies. It will also study the assembly of galaxies, star formation, and the formation of evolution of planetary systems. We will present an overview of the Observatory's current design following the Mission Preliminary Design Review, (PDR). Recent progress in hardware development for the observatory will be presented, including a discussion of the status of JWST's optical system and Beryllium mirror fabrication, progress with sunshield prototypes, and recent changes in the integration and test configuration. We also review the expected scientific performance of the observatory based on the mission PDR design.
    Keywords: Astronomy
    Type: 2008 International Year Astronomy - AAS; Jan 04, 2009 - Jan 08, 2009; Long Beach, CA; United States
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  • 93
    Publication Date: 2019-08-26
    Description: The present invention involves methods and devices which enable discrete objects having a conducting inner core, surrounded by a dielectric membrane to be selectively inactivated by electric fields via irreversible breakdown of their dielectric membrane. One important application of the invention is in the selection, purification, and/or purging of desired or undesired biological cells from cell suspensions. According to the invention, electric fields can be utilized to selectively inactivate and render non-viable particular subpopulations of cells in a suspension, while not adversely affecting other desired subpopulations. According to the inventive methods, the cells can be selected on the basis of intrinsic or induced differences in a characteristic electroporation threshold, which can depend, for example, on a difference in cell size and/or critical dielectric membrane breakdown voltage. The invention enables effective cell separation without the need to employ undesirable exogenous agents, such as toxins or antibodies. The inventive method also enables relatively rapid cell separation involving a relatively low degree of trauma or modification to the selected, desired cells. The inventive method has a variety of potential applications in clinical medicine, research, etc., with two of the more important foreseeable applications being stem cell enrichment/isolation, and cancer cell purging.
    Keywords: Life Sciences (General)
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  • 94
    facet.materialart.
    Unknown
    In:  CASI
    Publication Date: 2019-08-24
    Description: Method and system for monitoring present location and/or present status of a target inventory item, where the inventory items are located on one or more inventory shelves or other inventory receptacles that communicate with an inventory base station through use of responders such as RFIDs. A user operates a hand held interrogation and display (IAD) module that communicates with, or is part of, the base station, to provide an initial inquiry. Information on location(s) of the target inventory item is also indicated visibly and/or audibly on the receptacle(s) for the user. Status information includes an assessment of operation readiness and a time, if known, that the specified inventory item or class was last removed or examined or modified. Presentation of a user access level may be required for access to the target inventory item. Another embodiment provides inventory information for a stack as a sight-impaired or hearing-impaired person passes adjacent to that stack.
    Keywords: Life Sciences (General)
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  • 95
    Publication Date: 2019-07-12
    Description: We present deep Chandra observations and Spitzer Space Telescope infrared (IR) spectroscopy of the shell in the composite supernova remnant (SNR) Kes 75 (G29.7-0.3). The remnant is composed of a central pulsar wind nebula and a bright partial shell in the south that is visible at radio, IR, and X-ray wavelengths. The X-ray emission can be modeled by either a single thermal component with a temperature of ~ 1.5 keV, or with two thermal components with temperatures of 1.5 and 0.2 keV. Previous studies suggest that the hot component may originate from reverse-shocked SN ejecta. However, our new analysis shows no definitive evidence for enhanced abundances of Si, S, Ar, Mg, and Fe, as expected from supernova (SN) ejecta, or for the IR spectral signatures characteristic of confirmed SN condensed dust, thus favoring a circumstellar or interstellar origin for the X-ray and IR emission. The X-ray and ill emission in the shell are spatially correlated, suggesting that the dust particles are collisionally heated by the X-ray emitting gas. The IR spectrum of the shell is dominated by continuum emission from dust with little, or no line emission. Modeling the IR spectrum shows that the dust is heated to a temperature of ~ 140 K by a relatively dense, hot plasma, that also gives rise to the hot X-ray emission component. The density inferred from the IR emission is significantly higher than the density inferred from the X-ray models, suggesting a low filling factor for this X-ray emitting gas. The total mass of the warm dust component is at least 1.3 x 10(exp -2) solar mass, assuming no significant dust destruction has occurred in the shell. The IR data also reveal the presence of an additional plasma component with a cooler temperature, consistent with the 0.2 keV gas component. Our IR analysis therefore provides an independent verification of the cooler component of the X-ray emission. The complementary analyses of the X-ray and IR emission provide quantitative estimates of density and filling factors of the clumpy medium swept up by the SNR.
    Keywords: Astronomy
    Type: GSFC.JA.6941.2012
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  • 96
    Publication Date: 2019-07-12
    Description: The Extravehicular Activity (EVA) Risk Standing Review Panel (SRP) was favorably impressed by the operational risk management approach taken by the Human Research Program (HRP) Integrated Research Plan (IRP) to address the stated life sciences issues. The life sciences community at the Johnson Space Center (JSC) seems to be focused on operational risk management. This approach is more likely to provide risk managers with the information they need at the time they need it. Concerning the information provided to the SRP by the EVA Physiology, Systems, and Performance Project (EPSP), it is obvious that a great deal of productive activity is under way. Evaluation of this information was hampered by the fact that it often was not organized in a fashion that reflects the "Gaps and Tasks" approach of the overall Human Health Countermeasures (HHC) effort, and that a substantial proportion of the briefing concerned subjects that, while interesting, are not part of the HHC Element (e.g., the pressurized rover presentation). Additionally, no information was provided on several of the tasks or how they related to work underway or already accomplished. This situation left the SRP having to guess at the efforts and relationship to other elements, and made it hard to easily map the EVA Project efforts currently underway, and the data collected thus far, to the gaps and tasks in the IRP. It seems that integration of the EPSP project into the HHC Element could be improved. Along these lines, we were concerned that our SRP was split off from the other participating SRPs at an early stage in the overall agenda for the meeting. In reality, the concerns of EPSP and other projects share much common ground. For example, the commonality of the concerns of the EVA and exercise physiology groups is obvious, both in terms of what reduced exercise capacity can do to EVA capability, and how the exercise performed during an EVA could contribute to an overall exercise countermeasure prescription.
    Keywords: Life Sciences (General)
    Type: JSC-CN-19453
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  • 97
    Publication Date: 2019-07-12
    Description: We searched for X-ray shadowing toward two infrared dark clouds (IRDCs) using the MOS detectors on XMM-Newton to learn about the Galactic distribution of X-ray emitting plasma. IRDCs make ideal X-ray shadowing targets of 3/4 keY photons due to their high column densities, relatively large angular sizes, and known kinematic distances. Here we focus on two clouds near 30 deg Galactic longitude at distances of 2 and 5 kpc from the Sun. We derive the foreground and background column densities of molecular and atomic gas in the direction of the clouds. We find that the 3/4 ke V emission must be distributed throughout the Galactic disk. It is therefore linked to the structure of the cooler material of the ISM, and to the birth of stars.
    Keywords: Astronomy
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  • 98
    Publication Date: 2019-07-12
    Description: We report on the first Suzaku observation of IGR J16318-4848, the most extreme example of a new group of highly absorbed X-ray binaries that have recently been discovered by the International Gamma-Ray Astrophysics Laboratory (INTEGRAL). The Suzaku observation was carried out between 2006 August 14 and 17, with a net exposure time of 97 ks. The average X-ray spectrum of the source can be well described (chi-square (sub red)= 0.99) with a continuum model typical for neutron stars i.e., a strongly absorbed power law continuum with a photon index of 0.676(42) and an exponential cutoff at 20.5(6) keY. The absorbing column is N(sub H) = 1.95(3) X 10(exp 24)/square cm. Consistent with earlier work, strong fluorescent emission lines of Fe K-alpha, Fe K-beta, and Ni K-alpha are observed. Despite the large N(sub H), no Compton shoulder is seen in the lines, arguing for a non-spherical and inhomogeneous absorber. Seen at an average 5-60 keV absorbed flux of 3.4 x 10(exp -10) erg/square cm/second, the source exhibits significant variability on timescales of hours.
    Keywords: Astronomy
    Type: Astronomy and Astrophysics
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  • 99
    Publication Date: 2019-07-12
    Description: Because MIOl is nearly face-on, it provides an excellent laboratory in which to study the distribution of X-ray emitting gas in a typical late-type spiral galaxy. We obtained a Chandra observation with a cumulative exposure of roughly 1 Ms to study the diffuse X-ray emission in MlOl. The bulk of the X-ray emission is correlated with the star formation traced by the FUV emission. The global FUV/Xray correlation is non-linear (the X-ray surface brightness is roughly proportional to the square root of the FUV surface brightness) and the small-scale correlation is poor, probably due to the delay between the FUV emission and the X-ray production ill star-forming regions. The X-ray emission contains only minor contributions from unresolved stars (approximates less than 3%), unresolved X-ray point sources (approximates less than 4%), and individual supernova remnants (approximates 3%). The global spectrum of the diffuse emission can be reasonably well fitted with a three component thermal model, but the fitted temperatures are not unique; many distributions of emission measure can produce the same temperatures when observed with the current CCD energy resolution. The spectrum of the diffuse emission depends on the environment; regions with higher X-ray surface brightnesses have relatively stronger hard components, but there is no significant evidence that the temperatures of the emitting components increase with surface brightness.
    Keywords: Astronomy
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  • 100
    Publication Date: 2019-07-12
    Description: We present results from two observations of the wind-accreting X-ray pulsar 4U 1907+09 using the Suzaku observatory, The broadband time-averaged spectrum allows us to examine the continuum emission of the source and the cyclotron resonance scattering feature at approx. 19 keV. Additionally, using the narrow CCD response of Suzaku near 6 ke V allows us to study in detail the Fe K bandpass and to quantify the Fe Kp line for this source for the first time. The source is absorbed by fully-covering material along the line of sight with a column density of N(sub H) approx. 2 x 10(exp 22)/sq cm, consistent with a wind accreting geometry, and a high Fe abundance (approx. 3 - 4 x solar). Time and phase-resolved analyses allow us to study variations in the source spectrum. In particular, dips found in the 2006 observation which are consistent with earlier observations occur in the hard X-ray bandpass, implying a variation of the whole continuum rather than occultation by intervening material, while a dip near the end of the 2007 observation occurs mainly in the lower energies implying an increase in NH along the line of sight, perhaps indicating clumpiness in the stellar wind
    Keywords: Astronomy
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