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  • pharmacokinetics  (623)
  • Coleoptera  (148)
  • Angiosperms
  • CR: 5.17
  • Drosophila melanogaster
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  • 1
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    Dosage Forms (2023)
    IntechOpen | IntechOpen
    Details
    Publication Date: 2024-04-01
    Description: Dosage forms are pharmaceutical formulation products in the form in which they are presented in the market. They are a crucial component of contemporary pharmaceutical research. The field of dosage forms is large and diverse and includes everything from conventional solid and liquid dosage forms to more recent innovations like nanoparticles and gene therapy. This book provides a comprehensive overview of dosage forms, including their formulation and development. Chapters address such topics as novel dosage forms in ophthalmic applications, orally disintegrating tablets, layered tablets, pharmacokinetics and pharmacogenomics, and much more.
    Keywords: pharmacokinetics ; metabolism ; liposomes ; pharmacology ; biomaterial ; tuberculosis ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Language: English
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    E-BOOK
  • 2
    Electronic Resource
    Electronic Resource
    Enzymatic and pharmacokinetic studies on the metabolism of branched chain α-keto acids in the rat (1983)
    Springer
    European journal of nutrition 22 (1983), S. 14-26 
    Details
    ISSN: 1436-6215
    Keywords: branched chain α-keto acids ; 4-methyl-2-oxopentanoate, 3-methyl-2-oxopentanoate ; 3-methyl-2-oxobutyrate ; dehydrogenation ; transamination ; pharmacokinetics ; absorption
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Medicine
    Description / Table of Contents: Zusammenfassung Michaelis-Konstanten und Aktivitäten von Dehydrogenasen und Transaminasen der drei verzweigten α-Ketosäuren Keto-Valin, Keto-Leucin und Keto-Isoleucin in Leber, Niere, Skeletmuskel und Gehirn von Ratten werden mitgeteilt. Nach oraler Zufuhr passieren nur 11–22% der Ketosäuren unverändert die Leber. Aus pharmakokinetischen und Resorptions-Untersuchungen erhaltene Blutspiegel an Ketosäuren werden zu den Michaelis-Konstanten in Beziehung gesetzt. Bei den geringen Konzentrationen an Ketosäuren nach oraler Zufuhr kann angenommen werden, daß die oxidativen Prozesse in den nichthepatischen Geweben über die Transaminierung überwiegen. Daten über die Wachstumseffizienz von verzweigtkettigen α-Ketosäuren im Vergleich zu den entsprechenden Aminosäuren stimmen mit dieser Vorstellung überein. Bei intravenöser Verabreichung müßten die Voraussetzungen für Transaminierung besser sein als nach oraler Zufuhr. Auf der Basis von Daten aus der Literatur werden die Übertragbarkeit unserer Befunde auf den Menschen und die verschiedenen Faktoren, welche die Effizienz der verzweigten α-Ketosäuren durch Einwirkung auf ihren Stoffwechsel beeinflussen können, diskutiert.
    Notes: Summary Miehaelis-constants and enzyme activities for dehydrogenation and transamination of the three branched chainα-keto acids in liver, kidney, skeletal muscle, and brain of rats are reported. After oral load only 11–22 % of the keto acids pass the liver unchanged. Blood levels in pharmacokinetic and absorption studies are related to the Michaelis-constants. At the low keto-acid concentrations after oral application, dehydrogenation in the non-hepatic tissues is supposed to prevail over transamination. Data on feed efficiency of branched chain α-keto acids reported in the literature support this view. The chance for transamination is better after intravenous administration. The transferability of our data to humans, and various factors influencing the efficiency of branched chain α-keto acids are discussed in connection with data reported in the literature.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02020781
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  • 3
    Electronic Resource
    Electronic Resource
    Numerische Lösung gewöhnlicher Differentialgleichungen mit Splinefunktionen (1980)
    Springer
    Computing 25 (1980), S. 317-335 
    Details
    ISSN: 1436-5057
    Keywords: AMS (MOS): 65L65 ; CR: 5.17 ; AMS (MOS): 65L65 ; CR: 5.17
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Description / Table of Contents: Abstract In this paper a general procedure to obtain spline approximations for the solutions of initial value problems for ordinary differential equations is presented. Several well-known spline approximation methods are included as special cases. It is common practice to partition the interval for which the initial value problem is defined into equidistant subintervals and to construct successively the spline approximation; thereby the spline function has to satisfy certain conditions at the knots. In the general procedure presented here additional knots are admitted in every subinterval. At these points which need not be equally spaced the spline approximation has to fulfill analogous conditions as at the original knots. Convergence and divergence theorems are proved; especially the influence of the additional knots on convergence and divergence of the method is investigated.
    Notes: Zusammenfassung In dieser Arbeit wird ein allgemeines Verfahren zur Erzeugung von Splineapproximationen für die Lösungen von Anfangswertproblemen bei gewöhnlichen Differentialgleichungen vorgestellt. Einige der bekannten Spline-approximationsmethoden sind als Spezialfälle enthalten. Eine gängige Vorgehensweise besteht darin, das Intervall, über dem das Anfangswertproblem gegeben ist, in äquidistante Teilintervalle zu zerlegen und dann sukzessive die Splineapproximation zu definieren. Hierbei wird gefordert, daß die Spline-approximation in den Knoten gewisse Bedingungen erfüllt. Bei dem hier betrachteten allgemeinen Verfahren werden in den einzelnen Teilintervallen noch zusätzliche Zwischenknoten eingeführt. In diesen Punkten, die nicht äquidistant sein müssen, werden für die Splineapproximation analoge Bedingungen wie in den Hauptknoten vorgeschrieben. Konvergenz- und Divergenzsätze werden bewiesen, insbesondere wird der Einfluß der Zwischenknoten auf Konvergenz und Divergenz des Verfahrens untersucht.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02285227
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  • 4
    Electronic Resource
    Electronic Resource
    Behandlung steifer Anfangswertprobleme gewöhnlicher Differentialgleichungen mit adaptiven Runge-Kutta-Methoden (1982)
    Springer
    Computing 29 (1982), S. 153-165 
    Details
    ISSN: 1436-5057
    Keywords: 65L05 ; CR: 5.17 ; Numer. Analysis ; verallgemeinerte Runge-Kutta-Methoden ; steife Probleme
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Description / Table of Contents: Abstract Adaptive Runge-Kutta-methods are considered. Investigations of stability for these linear implicit methods are studied. For the application a LS-stable method of order four with an adaptive stepsize control is proposed. Test results for 25 stiff initial value problems for different tolerances are discussed.
    Notes: Zusammenfassung Es werden adaptive Runge-Kutta-Verfahren betrachtet und Stabilitätsuntersuchungen für diese linear impliziten Methoden durchgeführt. Für die Anwendung wird ein LS-stabiles Verfahren vierter Ordnung mit einer angepaßten Schrittweitenkontrolle vorgeschlagen. Testergebnisse von 25 stiff Anfangswertproblemen für verschiedenen Toleranzen werden diskutiert.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02249938
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  • 5
    Electronic Resource
    Electronic Resource
    Effect of the ecdysone agonists, methoxyfenozide and tebufenozide, on the lady beetle, Coleomegilla maculata (2000)
    Springer
    Entomologia experimentalis et applicata 94 (2000), S. 103-105 
    Details
    ISSN: 1570-7458
    Keywords: ecdysone agonists ; methoxyfenozide ; tebufenozide ; Ostrinia nubilalis ; Coleomegilla maculata ; Coleoptera ; Coccinellidae
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1003926704520
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  • 6
    Electronic Resource
    Electronic Resource
    Increasing the effectiveness of spring trap crops for Leptinotarsa decemlineata (2000)
    Springer
    Entomologia experimentalis et applicata 96 (2000), S. 193-204 
    Details
    ISSN: 1570-7458
    Keywords: cultural controls ; dispersal ; Colorado potato beetle ; Coleoptera ; Chrysomelidae
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Insecticide resistance problems have increased interest in trap crops as a cultural control strategy for overwintered Colorado potato beetle adults, Leptinotarsa decemlineata Say (Coleoptera: Chrysomelidae). Growers in the north central United States have noticed and treated concentrations of adults at the edge of some of their potato fields each spring. Based on sampling in commercial potato fields over a 2-year period, early planted fields that are adjacent to the previous year's potato crop are most likely to have concentrations of adults at the field edge. Frequency of fields with significantly more adults at the edges than in the center sections as well as adult population density in the center sections of fields declined with both distance from the previous potato field and later planting date. The effects of both physical and chemical barriers to movement into potato fields from the field edges were studied in small plot trials and at the edges of commercial potato fields. In small plot trials, physical barriers had a greater impact than chemical barriers on adult beetle movement from a potato trap crop to the protected potatoes beyond the barrier. Barrier treatments reduced beetle numbers in and just beyond the barrier in commercial fields, but the effects were localized and no significant reduction of beetles was observed further into the field. Beetle flight was hypothesized to be responsible for the localized effects of barrier treatments and the lack of edge concentrations in later planted and more distantly rotated fields. In field studies, larger potato plants attracted more colonizing potato beetles than smaller plants. Attracting Colorado potato beetles to trap crops containing potato plants that were larger than those in the remainder of the field, however, provided no significant reduction of beetles in the remainder of the field. We found little opportunity to reduce beetle populations with trap crops at the edges of potato fields without controlling the adults in the trap crop itself. Growers can exploit naturally occurring concentrations of adults at the edges of early and adjacent potato plantings if they are prepared to monitor and regularly treat the field edges.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1004009901244
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  • 7
    Electronic Resource
    Electronic Resource
    The role of chemical cues in host finding and acceptance by Callosobruchus chinensis (2000)
    Springer
    Entomologia experimentalis et applicata 96 (2000), S. 213-219 
    Details
    ISSN: 1570-7458
    Keywords: herbivore ; host finding ; olfactometer ; volatiles ; oviposition ; discrimination ; Coleoptera ; Bruchidae ; pest control
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract We studied the response of female Callosobruchus chinensis to chemical cues emitted by cowpea seeds at different stages of bruchid infestation (uninfested, egg carrying, L1-, and L4-infested). Olfactory attractiveness was determined in Y-tube olfactometer assays by testing individual seed categories against either clean air or uninfested seeds. Oviposition preferences between uninfested and infested seeds were determined in petri-dish choice-experiments. The olfactometer assays revealed that weevils discriminate between seeds containing different stages of developing bruchids on the basis of olfactory cues. While odors from uninfested and egg-carrying seeds acted as attractants, odors from L1- and L4-infested seeds failed to induce a positive response by the bruchids. When given a choice between uninfested and infested seeds in the olfactometer, weevils preferred uninfested seeds over L1- and L4-infested seeds, but failed to distinguish between uninfested and egg-carrying seeds. In the oviposition experiment as well, bruchids showed a distinct preference for uninfested seeds when offered in combination with L1- and L4-infested seeds. This experiment further showed a reduced acceptance of egg carrying seeds. Our results indicate that C. chinensis females use chemical information during both host searching and host acceptance. Volatiles from uninfested or egg carrying seeds act as attractants, while deterrence increases as development of bruchid immature stages progresses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1004016127866
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  • 8
    Electronic Resource
    Electronic Resource
    Selection of hibernation sites by Anthonomus pomorum: preferences and ecological consequences (2000)
    Springer
    Entomologia experimentalis et applicata 95 (2000), S. 241-249 
    Details
    ISSN: 1570-7458
    Keywords: Anthonomus pomorum ; apple blossom weevil ; Coleoptera ; Curculionidae ; hibernation ; mortality ; dispersal ; mark-release-recapture ; apple orchard
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The apple blossom weevil, Anthonomus pomorum (L.) (Coleoptera: Curculionidae), has a long period of aestivo-hibernation in the adult stage lasting from summer to early spring of the following year. Potential hibernation sites within an apple orchard consist of high-stem rough-bark trees or dwarf smooth-bark trees. Field release-recapture experiments in 2 consecutive years showed that 64 and 47% of the weevils remained in the vicinity of the release sites in an area of high-stem trees and dwarf trees, respectively. The dispersing weevils moved over an average distance of 5.5 m in the dwarf tree area, as compared to 3.8 m in the high-stem tree area. The prevalent direction of dispersal was along tree rows in both areas. Some weevils displayed, after release in mid-July, a directional dispersal to the adjacent forests. Others, released in the dwarf tree area, dispersed towards the area of high-stem rough-bark apple trees. Experiments simulating various hibernation sites demonstrated that the litter of dry leaves was the most preferred overwintering shelter, yielding a relatively high survival rate. Branches with rough bark ranked second, while branches with smooth bark, grass and pure soil were not favourable for overwintering. Flight tendency in newly emerged weevils of summer generation was significantly higher in June/July than in August/September. This corresponds to the dispersal behaviour in the field. The timing of spring colonisation of apple trees was similar for weevils overwintering within the orchard and for those from outside. These results suggest that modern, dwarf apple orchards offer unfavourable conditions for overwintering, but that the relatively small proportion of weevils which manage to reach the adjacent forests find optimal hibernation sites there.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1004046801897
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  • 9
    Electronic Resource
    Electronic Resource
    Behavioural responses of Oryzaephilus surinamensis, Tribolium castaneum and Tribolium confusum to naturally and artificially damaged durum wheat kernels (2000)
    Springer
    Entomologia experimentalis et applicata 94 (2000), S. 195-200 
    Details
    ISSN: 1570-7458
    Keywords: stored-products ; Coleoptera ; primary pests ; secondary pests ; behaviour ; host selection ; wheat kernel volatiles ; damaged kernels
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Observations on behavioural activity involved in the host selection by secondary pests of stored grains, Oryzaephilus surinamensis (Linnaeus), Tribolium castaneum (Herbst) and Tribolium confusum J. du Val, with respect to intact and mechanically or naturally damaged kernels are reported. Our results indicate that the attraction of secondary pests is facilitated by broken grain kernels, which resulted from either mechanical damage during harvesting and/or binning procedures, or the feeding activity of primary insect pests. Insect damaged kernels were more attractive to O. surinamensis, T. castaneum and T. confusum than whole kernels; in addition insect damaged kernels elicit more attractiveness than mechanically split kernels. The damage caused by primary pests, such as Rhyzopertha dominica (Fabricius) and Sitophilus oryzae (Linnaeus), on whole kernels may facilitate colonization by secondary pests, which continue damaging the cereals. O. surinamensis, T. castaneum and T. confusum utilize the grain volatile odours to distinguish whether the grain kernels of the stored cereals are damaged mechanically or by insects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1003929810978
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  • 10
    Electronic Resource
    Electronic Resource
    Pitfall-trap catches of the carabid beetle Pterostichus melanarius, in relation to gut contents and prey densities, in insecticide treated and untreated spring barley (1984)
    Springer
    Entomologia experimentalis et applicata 36 (1984), S. 23-30 
    Details
    ISSN: 1570-7458
    Keywords: Pterostichus melanarius ; Coleoptera ; Carabidae ; pitfall traps ; insecticides ; prey ; hunger ; activity ; Rhopalosiphum padi ; Fenitrothion ; Sumicidin (Fenvalerate) ; spring barley
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Description / Table of Contents: Résumé Au cours d'essais à grande échelle, effectués en 1981 et 1982, sur orge de printemps, pour évaleur l'effet des insecticides Fenitrothion et Sumicidine (fenvalerate) sur les arthropodes utiles, un accroissement significatif des captures, dans des trappes pièges de Barber, de Pterostichus melanarius (Illiger) a été observé plusierus semaines après le traitement dans les lots traités par rapport aux lots témoins. Significativement plus de femelles de P. melanarius ont été capturées dans les parcelles traitées pendant cette période d'accroissement après traitement. Une diminution correspondante dans les populations de proies a été observée à la suite des traitements. Chaque femelle de P. melanarius des parcelles traitées avait une fraction significativement moins importance de son intestin remplie d'aliments solides (arthropodes) que celles des parcelles non traitées. Des auteurs précédents avaient observé des taux de capture plus rapides dans les trappes et ne plus grande mobilité des carabes affamés. La réduction des populations proies par l'application d'insecticides affamerait les carabes dont l'activité serait par suite plus élevée. Comme le taux de captures dans les trappes est dû à la fois à la taille de la population et à son activité, on en déduit que la capture par trappes seule ne peut donner une image exacte de l'effet des insecticides sur les populations de carabes dans les champs.
    Notes: Abstract During large-scale field experiments in 1981 and 1982, designed to assess the effects of the insecticides Fenitrothion and Sumicidin (Fenvalerate) on beneficial arthropods in spring barley, significant increases in pitfall-trap catches of Pterostichus melanarius (Illiger) were observed in treated plots compared to untreated controls, several weeks after treatment. Significantly more female P. melanarius were caught in treated plots during these post-treatment increases. Corresponding decreases were observed in prey populations following treatments. Individual female P. melanarius from treated plots had significantly fewer of their gut areas full of solid (arthropod) food when compared to those from untreated control plots. Earlier workers observed both faster recapture rates in pitfalls and higher mobility in hungry carabid beetles. The following hypothesis is suggested: reducing prey populations by the application of insecticides results in hungrier carabid beetles with consequently higher activity. Since pitfall-trap catch is determined not only by population size but also activity, it is argued that pitfall-trap catches alone cannot give a true measure of the effects of insecticides on carabid populations in the field.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00345200
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