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Catalytic process technology (2005)

Washington, DC : National Academy of Sciences

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ISBN: 0-309-57629-6

URL: http://www.netLibrary.com/Details.aspx?ProductId=123544

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2

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News In Brief (2006)

[s.l.] : Nature Publishing Group

Nature biotechnology 24 (2006), S. 1048-1049

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] 200% ethanol boost from Oz sugar University of Queensland (UQ), Australia, molecular geneticist Robert Birch got more than he bargained for when he introduced a bacterial gene into sugarcane to convert sucrose into its high-value isomer, isomaltulose. In fact, the gene encoding sucrose isomerase, ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0706-1048

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3

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Profile of a bacterial tumor killer (2006)

Forbes, Neil S

[s.l.] : Nature Publishing Group

Nature biotechnology 24 (2006), S. 1484-1485

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Common bacteria, engineered to safely seek out and kill tumors, may well be the next generation of cancer therapeutics. In this issue, Bettegowda et al. report the genome sequence of one such bacterium, Clostridium novyi-NT, which has been engineered to be non-toxic by deleting the major systemic ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1206-1484

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4

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Anti-infective antibodies: finding the path forward (2006)

Baker, Monya

[s.l.] : Nature Publishing Group

Nature biotechnology 24 (2006), S. 1491-1493

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] This June, Basel-based Novartis Pharmaceuticals made a first reconnoiter into antimicrobial antibodies in its quest to find new weapons to fight infections. It paid $569 million to acquire NeuTec Pharmaceuticals of Manchester, UK, and its two late-stage products, both antibody fragments ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1206-1491

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5

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Prospects for plant-derived antibacterials (2006)

Lewis, Kim ; Ausubel, Frederick M

[s.l.] : Nature Publishing Group

Nature biotechnology 24 (2006), S. 1504-1507

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] The scarcity of disease in wild plants indicates that the success of plant defense mechanisms in combating pathogen infection rivals that of mammalian immune systems. Although there are some interesting parallels between plant and animal defense strategies—for instance, both groups sacrifice ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1206-1504

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6

Digitale Medien

Moving goalposts—regulatory oversight of antibacterial drugs (2006)

Brenner, Randall ; Ellis-Grosse, Evelyn J ; Echols, Roger

[s.l.] : Nature Publishing Group

Nature biotechnology 24 (2006), S. 1515-1519

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] The US Food and Drug Administration (FDA) has recently rejected new antibiotics for common infections citing the requirement that the drugs intended to treat non-serious infections prove superior to placebo rather than active controls. With the introduction of more stringent statistical criteria, ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1206-1515

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The business of developing antibacterials (2006)

Fox, Jeffrey L

[s.l.] : Nature Publishing Group

Nature biotechnology 24 (2006), S. 1521-1528

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] For developers of antibacterial products, this century began very much on the wrong foot. The number of pharmaceutical companies chasing antibiotics continued to drop, few genuinely new antibiotics reached the clinic and investors remained lukewarm toward startups in this sector. But, despite ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1206-1521

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8

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What is a support vector machine? (2006)

Noble, William S

[s.l.] : Nature Publishing Group

Nature biotechnology 24 (2006), S. 1565-1567

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] A support vector machine (SVM) is a computer algorithm that learns by example to assign labels to objects. For instance, an SVM can learn to recognize fraudulent credit card activity by examining hundreds or thousands of fraudulent and nonfraudulent credit card activity reports. Alternatively, an ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1206-1565

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9

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The genome and transcriptomes of the anti-tumor agent Clostridium novyi-NT (2006)

Bettegowda, Chetan ; Huang, Xin ; Lin, Jimmy ; [weitere]

[s.l.] : Nature Publishing Group

Nature biotechnology 24 (2006), S. 1573-1580

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Bacteriolytic anti-cancer therapies employ attenuated bacterial strains that selectively proliferate within tumors. Clostridium novyi-NT spores represent one of the most promising of these agents, as they generate potent anti-tumor effects in experimental animals. We have determined the 2.55-Mb ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1256

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10

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Blue fluorescent proteins with enhanced brightness and photostability from a structurally targeted library (2006)

Mena, Marco A ; Treynor, Thomas P ; Mayo, Stephen L ; [weitere]

[s.l.] : Nature Publishing Group

Nature biotechnology 24 (2006), S. 1569-1571

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] The utility of blue fluorescent protein (BFP) has been limited by its low quantum yield and rapid photobleaching. A library targeting residues neighboring the chromophore yielded a variant with enhanced quantum yield (0.55 versus 0.34), reduced pH sensitivity and a 40-fold increase in ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1264

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11

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Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies (2006)

Sahl, Hans-Georg ; Hancock, Robert E W

[s.l.] : Nature Publishing Group

Nature biotechnology 24 (2006), S. 1551-1557

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Short cationic amphiphilic peptides with antimicrobial and/or immunomodulatory activities are present in virtually every life form, as an important component of (innate) immune defenses. These host-defense peptides provide a template for two separate classes of antimicrobial drugs. Direct-acting ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1267

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12

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The art of mismanagement (2006)

[s.l.] : Nature Publishing Group

Nature biotechnology 24 (2006), S. 1300-1300

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Is it possible that ImClone didn't do its homework on Erbitux's ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1106-1300a

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13

Digitale Medien

Merck wipes Serono off Swiss biotech map (2006)

Urquhart, Lisa

[s.l.] : Nature Publishing Group

Nature biotechnology 24 (2006), S. 1303-1303

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] On the average report card a test score of three out of five would usually draw the comment 'could do better'. The admonishment to try harder was also given by some observers to Darmstadt-based Merck KGaA's surprise €10.6- ($13.2)-billion acquisition of Serono on September 21. Although ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1106-1303

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14

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The protection racket (2006)

Jacobs, Tom

[s.l.] : Nature Publishing Group

Nature biotechnology 24 (2006), S. 1081-1081

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Biotech stocks can be white-knuckle volatile, but there is a way you can profit from, or insure against, such rapid and dramatic price changes. Through put and call options, you may not only make more profits, but also buy and sell 'protection' for your investments (with no need for 'knuckle' ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0906-1081

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15

Digitale Medien

Recent patent applications in tissue engineering (2006)

[s.l.] : Nature Publishing Group

Nature biotechnology 24 (2006), S. 1095-1095

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Recent patent applications in tissue engineering ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0906-1095

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16

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Evidence and anecdotes: an analysis of human gene patenting controversies (2006)

Caulfield, Timothy ; Cook-Deegan, Robert M ; Kieff, F Scott ; [weitere]

[s.l.] : Nature Publishing Group

Nature biotechnology 24 (2006), S. 1091-1094

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Gene patenting has attracted intense scrutiny for decades, raising a host of ethical, legal and economic concerns. Much of the policy debate has focused on seemingly quantifiable and practical concerns about the effect of patents on access to useful technologies in the contexts of both research and ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0906-1091

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17

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Lack of correct data format and comparability limits future integrative microarray research (2006)

Larsson, Ola ; Sandberg, Rickard

[s.l.] : Nature Publishing Group

Nature biotechnology 24 (2006), S. 1322-1323

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] To the editor: One of the challenges for the future is how to integrate all the DNA microarray data that have been generated and deposited in public databases. We have studied data from two data repositories and identified that only 38% meet necessary quality and data format standards. Our results ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1106-1322

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18

Digitale Medien

Artificial sperm and epigenetic reprogramming (2006)

Lucifero, Diana ; Reik, Wolf

[s.l.] : Nature Publishing Group

Nature biotechnology 24 (2006), S. 1097-1098

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Of the many differentiated cell types that have been derived in vitro from mouse embryonic stem (ES) cells, among the most intriguing are cells resembling male and female gametes. Such ES cell–derived germ cells have been shown to undergo meiosis to form haploid gametes that can support early ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0906-1097

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19

Digitale Medien

Trust, patents and public perceptions: the governance of controversial biotechnology research (2006)

Caulfield, Timothy ; Einsiedel, Edna ; Merz, Jon F ; [weitere]

[s.l.] : Nature Publishing Group

Nature biotechnology 24 (2006), S. 1352-1354

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] The increasingly commercial nature of biomedical research is, rightly or not, a reality of the contemporary research environment. The percentage of biomedical research supported by industry continues to grow, and many public funding agencies now encourage industry partnerships. Although links with ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1106-1352

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20

Digitale Medien

Engineering the essence of plants (2006)

Bouwmeester, Harro J

[s.l.] : Nature Publishing Group

Nature biotechnology 24 (2006), S. 1359-1361

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Plant-derived 'essential oils' such as terpenoids are widely used in the fragrance and flavor industries. In this issue, Chappell and colleagues describe an approach for engineering plants that produce elevated levels of commercially relevant terpenoids. They co-express both an enzyme that supplies ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1106-1359

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21

Digitale Medien

Connecting genes, drugs and diseases (2006)

Weinstein, John N ; Pommier, Yves

[s.l.] : Nature Publishing Group

Nature biotechnology 24 (2006), S. 1365-1366

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] The rallying cry of early 21st century biomedical science is that new combinations of genomic, proteomic and bioinformatic research will provide deeper insights into disease mechanisms, novel markers for diagnostics and new molecular targets for therapeutic intervention. DNA and protein microarrays ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1106-1365

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22

Digitale Medien

Are we stuck in the standards? (2006)

Ball, Catherine A

[s.l.] : Nature Publishing Group

Nature biotechnology 24 (2006), S. 1374-1376

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Trying to make some sense of it all, But I can see that it makes no sense at all, Is it cool to go to sleep on the floor, 'Cause I don't think that I can take anymore Clowns to the left of me, jokers to the right, Here I am, stuck in the middle with you. Joe Egan and Gerry Rafferty There are ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1106-1374

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23

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Corrigendum: Can science resolve the ethical impasse in stem cell research? (2006)

[s.l.] : Nature Publishing Group

Nature biotechnology 24 (2006), S. 1448-1448

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Nat. Biotechnol. 24, 397–400 (2006); published online 29 March 2006; corrected after print 8 November 2006. In the version of this article initially published, on page 399, column 2, paragraph 4, the authors wrongly credited the idea for using cells from nonviable human embryos as an ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1106-1448c

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24

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Compact, universal DNA microarrays to comprehensively determine transcription-factor binding site specificities (2006)

Berger, Michael F ; Philippakis, Anthony A ; Qureshi, Aaron M ; [weitere]

[s.l.] : Nature Publishing Group

Nature biotechnology 24 (2006), S. 1429-1435

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Transcription factors (TFs) interact with specific DNA regulatory sequences to control gene expression throughout myriad cellular processes. However, the DNA binding specificities of only a small fraction of TFs are sufficiently characterized to predict the sequences that they can and cannot bind. ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1246

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25

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Reversal of mouse hepatic failure using an implanted liver-assist device containing ES cell–derived hepatocytes (2006)

Soto-Gutiérrez, Alejandro ; Rivas-Carrillo, Jorge David ; Navarro-Álvarez, Nalu ; [weitere]

[s.l.] : Nature Publishing Group

Nature biotechnology 24 (2006), S. 1412-1419

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Severe acute liver failure, even when transient, must be treated by transplantation and lifelong immune suppression. Treatment could be improved by bioartificial liver (BAL) support, but this approach is hindered by a shortage of human hepatocytes. To generate an alternative source of cells for BAL ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1257

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26

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Vaccine manufacturing: challenges and solutions (2006)

Valley, Ulrich ; Rappuoli, Rino ; Ulmer, Jeffrey B

[s.l.] : Nature Publishing Group

Nature biotechnology 24 (2006), S. 1377-1383

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] The recent influenza vaccine shortages have provided a timely reminder of the tenuous nature of the world's vaccine supply and the potential for manufacturing issues to severely disrupt vital access to important vaccines. The application of new technologies to the discovery, assessment, development ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1261

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27

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Making the most of microarrays (2006)

[s.l.] : Nature Publishing Group

Nature biotechnology 24 (2006), S. 1039-1039

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] No technology embodies the rise of 'omic' science more than the DNA microarray. First reduced to practice in the early 1990s, it has since undergone numerous iterations, adaptations and refinements to achieve its present status as the platform of choice for massively parallel gene expression ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1006-S1

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28

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Brazil next biotech trailblazer in Latin America? (2006)

Bonalume, Ricardo

[s.l.] : Nature Publishing Group

Nature biotechnology 24 (2006), S. 1184-1184

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] One year on from the enforcement of Brazil's innovation law, the first national innovation law in Latin America, it has already earned praise from the country's scientific community, especially from that part dealing with applied research in industry and agriculture, with an emphasis on biotech. ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1006-1184

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29

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Profile: Michael Fernandez (2006)

Powell, Kendall

[s.l.] : Nature Publishing Group

Nature biotechnology 24 (2006), S. 1188-1188

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] When Michael Fernandez took over as director of the Pew Initiative on Food and Biotechnology (PIFB) in September 2005, his former boss bequeathed to him a lava lamp for his desk. Oddly enough, the lamp had been the prize for a Halloween costume that parodied Fernandez' image as a dapper science ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1006-1188

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Reactions to Eprex's adverse reactions (2006)

Sharma, Basant ; Ryan, Mary H. ; Boven, Katia

[s.l.] : Nature Publishing Group

Nature biotechnology 24 (2006), S. 1199-1200

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] To the editor: In their letter of correspondence “Eprex-associated pure red cell aplasia and leachates” in the June issue (Nat. Biotechnol. 24, 613–614, 2006), Schellekens & Jiskoot discuss what they consider to be flaws in Johnson & Johnson's (J&J; New Brunswick, NJ, ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1006-1199

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Digitale Medien

Biotech buybacks—good or bad? (2006)

Jacobs, Tom

[s.l.] : Nature Publishing Group

Nature biotechnology 24 (2006), S. 1207-1207

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Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] When a biotech company succeeds, it can find more cash in the bank than needed for research and development. It may decide to buy back, or repurchase, its own shares. A buyback is neither good nor bad by definition, but may be smart, dumb or bordering on fraudulent. To make you a savvier, more ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1006-1207

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Digitale Medien

The art of gene function prediction (2006)

Murali, T M ; Wu, Chang-Jiun ; Kasif, Simon

[s.l.] : Nature Publishing Group

Nature biotechnology 24 (2006), S. 1474-1475

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Notizen: [Auszug] To the editor: Determining the functions of genes and proteins is a central problem in biology, fundamental to understanding the molecular and biochemical processes that sustain health or cause disease, to identifying and validating new drug targets and to developing reliable diagnostics. Recent ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1206-1474

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Digitale Medien

Putting proteins on the map (2006)

Murphy, Robert F

[s.l.] : Nature Publishing Group

Nature biotechnology 24 (2006), S. 1223-1224

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Notizen: [Auszug] The emergence of systems biology has led to a demand for quantitative, comprehensive data on all aspects of biological phenomena. Some aspects, such as RNA expression and protein structure, have received much attention, while others, such as protein location, have lagged behind. In this issue, ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1006-1223

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Digitale Medien

Deciphering bioplastic production (2006)

Lee, Sang Yup

[s.l.] : Nature Publishing Group

Nature biotechnology 24 (2006), S. 1227-1229

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Notizen: [Auszug] The shift toward sustainable production systems has focused attention on bioplastics, which can be produced by many microorganisms from renewable raw materials. Polyhydroxyalkanoates (PHAs) are natural polyesters synthesized in the form of discrete intracellular granules in abundances that can ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1006-1227

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Digitale Medien

Wastewater genomics (2006)

Mino, Takashi ; Satoh, Hiroyasu

[s.l.] : Nature Publishing Group

Nature biotechnology 24 (2006), S. 1229-1230

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Notizen: [Auszug] Wastewater treatment around the world relies largely on microbial ecosystems, yet little is known about the organisms involved. This 'black box' system mediates aerobic and anaerobic processes that diminish high phosphate loads in wastewaters, a process known as enhanced biological phosphate ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1006-1229

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Digitale Medien

Biosynthetic labeling of RNA with uracil phosphoribosyltransferase allows cell-specific microarray analysis of mRNA synthesis and decay (2005)

Cleary, Michael D ; Meiering, Christopher D ; Jan, Eric ; [weitere]

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 232-237

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Notizen: [Auszug] Standard microarrays measure mRNA abundance, not mRNA synthesis, and therefore cannot identify the mechanisms that regulate gene expression. We have developed a method to overcome this limitation by using the salvage enzyme uracil phosphoribosyltransferase (UPRT) from the protozoan Toxoplasma ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1061

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Digitale Medien

Complete genome sequence of the acetic acid bacterium Gluconobacter oxydans (2005)

Prust, Christina ; Hoffmeister, Marc ; Liesegang, Heiko ; [weitere]

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 195-200

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Notizen: [Auszug] Gluconobacter oxydans is unsurpassed by other organisms in its ability to incompletely oxidize a great variety of carbohydrates, alcohols and related compounds. Furthermore, the organism is used for several biotechnological processes, such as vitamin C production. To further our understanding of ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1062

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Digitale Medien

Detection of parallel functional modules by comparative analysis of genome sequences (2005)

Li, Huiying ; Pellegrini, Matteo ; Eisenberg, David

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 253-260

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Notizen: [Auszug] Parallel functional modules are separate sets of proteins in an organism that catalyze the same or similar biochemical reactions but act on different substrates or use different cofactors. They originate by gene duplication during evolution. Parallel functional modules provide versatility and ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1065

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Digitale Medien

Corrigendum: ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe (2006)

[s.l.] : Nature Publishing Group

Nature biotechnology 24 (2006), S. 1033-1033

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Notizen: [Auszug] Nat. Biotechnol. 24, 841–847 (2006); published online 25 June 2006; corrected after print 25 July 2006 In the print version of this article and the version initially published online, the last sentence of the URLs section in Methods, p.846, reads, “Sequence information regarding the ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0806-1033a

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Digitale Medien

Minimum information requested in the annotation of biochemical models (MIRIAM) (2005)

Finney, Andrew ; Hucka, Michael ; Bhalla, Upinder S ; [weitere]

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1509-1515

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Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Most of the published quantitative models in biology are lost for the community because they are either not made available or they are insufficiently characterized to allow them to be reused. The lack of a standard description format, lack of stringent reviewing and authors' carelessness are the ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1156

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Digitale Medien

The complete genome sequence of the meat-borne lactic acid bacterium Lactobacillus sakei 23K (2005)

Chaillou, Stéphane ; Champomier-Vergès, Marie-Christine ; Cornet, Monique ; [weitere]

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1527-1533

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Notizen: [Auszug] Lactobacillus sakei is a psychrotrophic lactic acid bacterium found naturally on fresh meat and fish. This microorganism is widely used in the manufacture of fermented meats and has biotechnological potential in biopreservation and food safety. We have explored the 1,884,661-base-pair (bp) circular ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1160

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Digitale Medien

Efficient differentiation of human embryonic stem cells to definitive endoderm (2005)

D'Amour, Kevin A ; Agulnick, Alan D ; Eliazer, Susan ; [weitere]

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1534-1541

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Notizen: [Auszug] The potential of human embryonic stem (hES) cells to differentiate into cell types of a variety of organs has generated much excitement over the possible use of hES cells in therapeutic applications. Of great interest are organs derived from definitive endoderm, such as the pancreas. We have ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1163

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Digitale Medien

Combined static and dynamic analysis for determining the quality of time-series expression profiles (2005)

Simon, Itamar ; Siegfried, Zahava ; Ernst, Jason ; [weitere]

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1503-1508

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Notizen: [Auszug] Expression profiling of time-series experiments is widely used to study biological systems. However, determining the quality of the resulting profiles remains a fundamental problem. Because of inadequate sampling rates, the effect of arrest-and-release methods and loss of synchronization, the ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1164

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Digitale Medien

Corrigendum: Design of a genome-wide siRNA library using an artificial neural network (2006)

[s.l.] : Nature Publishing Group

Nature biotechnology 24 (2006), S. 1033-1033

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Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Nat. Biotechnol. 23, 995–1001 (2005), published online 17 July 2005; corrected after print 25 July 2006 In the Methods section, p. 1,000, col. 2, paragraph 2, the text beginning: “The whole plate was discarded if for any time point...” and ending, “The final data set ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0806-1033e

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Digitale Medien

Corrigendum: Dual selection enhances the signaling specificity of a variant of the quorum-sensing transcriptional activator LuxR (2006)

[s.l.] : Nature Publishing Group

Nature biotechnology 24 (2006), S. 1033-1033

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Notizen: [Auszug] Nat. Biotechnol. 24, 708–712 (2006); published online 21 May 2006; corrected after print 25 July 2006 In the Methods section, p.711, “Library construction and selection,” line 11 of the print version of this article and the version initially published online, the plates used for ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0806-1033c

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Digitale Medien

Inference in Bayesian networks (2006)

Needham, Chris J ; Bradford, James R ; Bulpitt, Andrew J ; [weitere]

[s.l.] : Nature Publishing Group

Nature biotechnology 24 (2006), S. 51-53

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Notizen: [Auszug] How does one model a simple cell-signaling pathway? Consider a simple example consisting of a stimulant, an extracellular signal, an inhibitor of the signal, a G protein–coupled receptor, a G protein and the cellular response. The stimulant induces production of the extracellular signal in ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0106-51

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Digitale Medien

Engineering and characterization of a superfolder green fluorescent protein (2006)

Pédelacq, Jean-Denis ; Cabantous, Stéphanie ; Tran, Timothy ; [weitere]

[s.l.] : Nature Publishing Group

Nature biotechnology 24 (2006), S. 79-88

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Notizen: [Auszug] Existing variants of green fluorescent protein (GFP) often misfold when expressed as fusions with other proteins. We have generated a robustly folded version of GFP, called 'superfolder' GFP, that folds well even when fused to poorly folded polypeptides. Compared to 'folding reporter' GFP, a ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1172

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Digitale Medien

Extracellular accumulation of recombinant proteins fused to the carrier protein YebF in Escherichia coli (2006)

Zhang, Guijin ; Brokx, Stephen ; Weiner, Joel H

[s.l.] : Nature Publishing Group

Nature biotechnology 24 (2006), S. 100-104

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Notizen: [Auszug] Bacterial protein secretion is important in the life cycles of most bacteria, in which it contributes to the formation of pili and flagella and makes available extracellular enzymes to digest polymers for nutritional purposes and toxins to kill host cells in infections of humans, animals and ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1174

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Digitale Medien

Transgenic crops expressing Bacillus thuringiensis toxins and biological control (2006)

Meissle, Michael ; Bigler, Franz ; Romeis, Jörg

[s.l.] : Nature Publishing Group

Nature biotechnology 24 (2006), S. 63-71

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Notizen: [Auszug] The area devoted to growing transgenic plants expressing insecticidal Cry proteins derived from Bacillus thuringiensis (Bt) is increasing worldwide. A major concern with the adoption of Bt crops is their potential impact on nontarget organisms including biological control organisms. Regulatory ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1180

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Digitale Medien

Tysabri back on market (2006)

Sheridan, Cormac

[s.l.] : Nature Publishing Group

Nature biotechnology 24 (2006), S. 874-874

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Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] The return of the multiple sclerosis (MS) drug Tysabri (natalizumab) to the US market, sanctioned by the US Food and Drug Administration (FDA) on June 5, and its first-time approval in the EU, announced on June 29, was welcomed by investors. The move should also eventually lead to a clearer ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0806-874

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Alfimeprase to succeed Genentech's alteplase? (2006)

Vastag, Brian

[s.l.] : Nature Publishing Group

Nature biotechnology 24 (2006), S. 875-876

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Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Nuvelo is forging ahead with phase 3 trials on its blood-clot buster enzyme alfimeprase, with results expected early next year. The recombinant enzyme attracted the attention of Bayer Healthcare, which earlier this year signed a $385-million deal for alfimeprase's non-US rights—an ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0806-875

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Digitale Medien

The problem with potency (2005)

Scott, Christopher Thomas

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1037-1039

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Notizen: [Auszug] As the $30 billion monoclonal antibody (mAb) market moves from murine-based to chimeric and fully human products, it grows at a compounded clip of nearly 20% per year (see ). This spectacular growth—Synagis (pavilivizumb; MedImmune, Gaithersburg, Maryland), Herceptin (trastuzumab; ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0905-1037

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Problems with metagenomic screening (2005)

de Lorenzo, Victor

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1045-1045

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Notizen: [Auszug] To the editor: The paper by Kazuya Watanabe and colleagues published in the January issue (Nat. Biotechnol. 23, 88–93, 2005) is framed both in the paper itself and in the accompanying News & Views by Jo Handelsman (Nat. Biotechnol. 23, 38–39, 2005) as an astute, general genetic ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0905-1045a

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Reply to "Problems with metagenomic screening" (2005)

Watanabe, Kazuya ; Uchiyama, Taku

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1045-1046

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Notizen: [Auszug] Watanabe and colleagues respond: de Lorenzo outlines some possible limitations of the substrate-induced gene expression screening (SIGEX) method. Although we discussed many of the points in his letter in our paper, it is worth reiterating them to emphasize the challenges faced in designing a ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0905-1045b

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Digitale Medien

Open source and biotech (2005)

Bains, William

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1046-1046

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Notizen: [Auszug] To the editor: Your editorial in the June issue (Nat. Biotechnol. 23, 633, 2005) on the biotech open source movement skirted round one critical difference between biotech and the software industry whose 'open source' movement Richard Jefferson seeks to emulate. Writing software is cheap and can be ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0905-1046

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Diagnostics investors think positive (2006)

[s.l.] : Nature Publishing Group

Nature biotechnology 24 (2006), S. 884-884

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Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Diagnostics companies have had record fundraising on the public markets over the past few years. Venture capital also expanded last year, raising more than double than in previous years, with $113 million the average quarterly amount raised over the past year compared with only $47 ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0806-884

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Looking for solid ground along the Critical Path (2006)

Ratner, Mark

[s.l.] : Nature Publishing Group

Nature biotechnology 24 (2006), S. 885-887

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Even as the science supporting innovation in drug and device development moves forward, the US agency charged with evaluating the products of that science remains embroiled in battles over resources and even its proper mandate. Indeed, the Food and Drug Administration (FDA, Rockville, MD, USA), ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0806-885

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Genetic profiteering (2006)

De Francesco, Laura

[s.l.] : Nature Publishing Group

Nature biotechnology 24 (2006), S. 888-890

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Once the province of clinical genetics units in hospitals and clinics, genetic tests have become a commodity. With the click of a mouse, you can order up tests to find out whether you are a carrier of the cystic fibrosis (CF) gene, prone to cardiovascular disease or a member of an ancient tribe. ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0806-888

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Automated phosphorylation site mapping (2006)

Jensen, Ole N

[s.l.] : Nature Publishing Group

Nature biotechnology 24 (2006), S. 1226-1227

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Mass spectrometry (MS) allows the localization of phosphorylated amino acid residues in proteins. Precise annotation of phosphorylation sites is not trivial, however, because of the inherent complexity of most phosphopeptide mass spectra. In this issue, Beausoleil et al. report computational ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1006-1226

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Should we make a fuss? (2006)

Witkowski, Jan A.

[s.l.] : Nature Publishing Group

Nature biotechnology 24 (2006), S. 899-899

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] To the editor: In their commentary in the December issue (Nat. Biotechnol. 23, 1479–1480, 2005) Jon Beckwith and Franklin Huang chastise T. H. Morgan for his failure to make a fuss about eugenics in 1915. That year, he gave the Vanuxem Lectures at Princeton University, which were published ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0806-899a

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Should we make a fuss? (2006)

Miller, Henry I. ; Conko, Gregory

[s.l.] : Nature Publishing Group

Nature biotechnology 24 (2006), S. 899-900

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] To the editor: An endorsement of ethical responsibility in science is difficult to oppose. The challenge, however, often is to ascertain what constitutes an ethical or wise course of action. In their commentary, Beckwith and Huang allude specifically to a “stirring of the scientific ...

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URL: http://dx.doi.org/10.1038/nbt0806-899b

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Export signals (2006)

Gál, Péter ; Végh, Barbara ; Závodszky, Péter ; [weitere]

[s.l.] : Nature Publishing Group

Nature biotechnology 24 (2006), S. 900-901

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] To the editor: The letter by Katariina Majander et al. in last year's April issue (Nat. Biotechnol. 23, 475–481, 2005) described the use of a modified flagellar type III secretion system (TTSS) to secrete heterologous polypeptides into the growth medium of Escherichia coli. N-terminal ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0806-900

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Reply to Export signals (2006)

[s.l.] : Nature Publishing Group

Nature biotechnology 24 (2006), S. 901-902

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Katariina Majander et al. respond In contrast to the comments of Gál et al., the aim of our paper was not to address the nature of the secretion signal motif per se but to evaluate the biotechnological potential of the secretion system. We did, however, briefly discuss the three proposed ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0806-901

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What brown cannot do for you (2006)

Rimm, David L

[s.l.] : Nature Publishing Group

Nature biotechnology 24 (2006), S. 914-916

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Chromogenic stains have been a mainstay as readouts for immunodiagnostics. 'Brown' staining—also known as diaminobenzidine (DAB) chromogenic staining or immunoperoxidase staining—was adopted very early in anatomic pathology and rapidly became the standard for immunohistochemistry in ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0806-914

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Protein annotation by EBIMed (2006)

Rebholz-Schuhmann, Dietrich ; Kirsch, Harald ; Arregui, Miguel ; [weitere]

[s.l.] : Nature Publishing Group

Nature biotechnology 24 (2006), S. 902-903

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] To the editor: PubMed is the key retrieval engine for Medline abstracts, and its host, the US National Library of Medicine (NLM; Bethesda, Maryland), provides efficient query interfaces. The result of queries is a list of abstracts, in which the most recent documents appear at the top. If the list ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0806-902

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Cancer biomarkers: a systems approach (2006)

Hartwell, Lee ; Mankoff, David ; Paulovich, Amanda ; [weitere]

[s.l.] : Nature Publishing Group

Nature biotechnology 24 (2006), S. 905-908

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Biomarkers measured in a variety of patient samples, including blood, tissue, urine and cerebrospinal fluid, are used in a diverse array of clinical settings. Although many successful biomarkers have been developed to date, advances in genetics and proteomics promise to usher in a new era of ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0806-905

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Synthesis & sequencing (2005)

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1019-1019

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Nanotech-based sequencing Roche and 454 Life Sciences, a subsidiary of CuraGen, offer a nanotechnology-based genome sequencing system that allows a single instrument to produce over 20 million nucleotide bases per 4-hour run, totaling more than 100 times the capacity of instruments using current ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0805-1019a

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Illuminating BiDil (2005)

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 903-903

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] BiDil is a recently approved therapy indicated for congestive heart failure patients already taking standard treatments. It is not a new drug. It is a combination of two existing drugs—isosorbide dinitrate and hydralazine—already marketed seperately as generics. What is new about BiDil ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0805-903

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Japan-China merger puts growth in East Asia first (2005)

Sipp, Doug

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 907-907

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] The Tokyo-based pharmaceutical development firm GNI announced its merger with Shanghai Genomics on June 20, marking the first such partnership between a Japanese and a Chinese biotech in over a decade. The newly formed venture has a research staff of more than 80 in Japan, China and England, and a ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0805-907

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Profile: William Haseltine (2005)

Herrera, Stephan

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 913-913

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] During the 13 years that he was CEO of Human Genome Sciences (HGS), William Haseltine rarely traveled for pleasure. He was even less mobile before his tenure at the Rockville, Maryland–based genomics firm that he founded in 1992; as a cancer and AIDS researcher at the Dana Farber Cancer ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0805-913

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Enthusiasm cools in Q2 (2005)

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 914-914

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Although private financing and overall funding remain relatively stable, investor interest in biotech is a shadow of a year ago, when the initial public offering (IPO) market had just come off the best two quarters of this window. The BioCentury 100 Index has fallen by a little more than 10%, and ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0805-914

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A regulatory perspective on in vitro diagnostics (2006)

Gottlieb, Scott ; Woodcock, Janet

[s.l.] : Nature Publishing Group

Nature biotechnology 24 (2006), S. 927-929

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] In vitro diagnostics (IVDs) has been an area of considerable innovation over the past decade, transforming the practice of medicine in the process. In the area of cardiovascular care alone, new markers for early cardiac injury and for heart failure have fundamentally changed the way doctors manage ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0806-927

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Any diamonds in the diagnostic coal? (2006)

Jacobs, Tom

[s.l.] : Nature Publishing Group

Nature biotechnology 24 (2006), S. 930-930

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Although you might have been led to believe there is a 'clear vision' for the molecular diagnostics revolution, in reality the investing picture is much murkier. Revenues haven't produced much profit or free cash flow (and are unlikely to do so anytime soon). And rather than stand-alone diagnostics ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0806-930

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Fishing for cancer models (2006)

Grabher, Clemens ; Look, A Thomas

[s.l.] : Nature Publishing Group

Nature biotechnology 24 (2006), S. 45-46

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Fish have been used as models in cancer research for almost a century because of the strikingly similar histopathological features of fish and human tumors. Despite this agreement, however, very little is known about the correspondence of the molecular mechanisms that drive tumorigenesis in these ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0106-45

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si RNA becomes smart and intelligent (2005)

Miyagishi, Makoto ; Taira, Kazunari

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 946-947

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] In just a few years, small interfering RNA (siRNA) has emerged as a powerful technology to specifically knockdown genes in mammalian cells both for functional analysis and for therapeutic purposes. The success of this approach, also called RNA interference (RNAi), hinges on the affinity of an siRNA ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0805-946

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Probabilistic model of the human protein-protein interaction network (2005)

Rhodes, Daniel R ; Tomlins, Scott A ; Varambally, Sooryanarayana ; [weitere]

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 951-959

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] A catalog of all human protein-protein interactions would provide scientists with a framework to study protein deregulation in complex diseases such as cancer. Here we demonstrate that a probabilistic analysis integrating model organism interactome data, protein domain data, genome-wide gene ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1103

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Pessimistic response to FDA leadership change (2005)

Kling, Jim

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1325-1325

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] In September, Lester Crawford resigned as commissioner of the US Food and Drug Administration (FDA), leaving a leadership vacuum that was quickly filled by President Bush's appointment of Andrew von Eschenbach, formerly the director of the National Cancer Institute (NCI), as acting commissioner. ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1105-1325

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Sandoz sues FDA over delay in first biogeneric approval (2005)

Fox, Jeffrey L.

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1327-1328

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Officials at Sandoz, the generic branch of Novartis of Basel, filed a rare type of lawsuit with the US District Court on September 13. The company wants the court to force the US Food and Drug Administration (FDA) to rule on—preferably, approve—Omnitrope, its follow-on version of ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1105-1327

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News In Brief (2005)

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1329-1330

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Cabilly patent invalidated Genentech's stronghold on monoclonal antibody production techniques may slip if a recent US Patent and Trademark Office's (USPTO) initial ruling is upheld. In late September, the USPTO rejected the company's ubiquitous Cabilly 2 patent on the grounds that it extends the ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1105-1329

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Biotech marks time in Q3 (2005)

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1332-1332

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Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] In a risk-averse market, biotech stock market indices showed sluggish growth, being outperformed by broader market indicators. Venture capital funding remained relatively stable but public biotechs were able to take advantage of debt, private investment in public equitities (PIPEs) and follow-on ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1105-1332

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Profile: Eduardo Kac (2005)

Herrera, Stephan

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1331-1331

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Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Is Chicago artist-writer-philosopher Eduardo Kac ahead of his time or just nuts? In the foreword of his new book, Art Institute of Chicago art historian James Elkins makes the case for the former. Elkins acknowledges, however, that not everybody agrees on this point and cites the negative critiques ...

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URL: http://dx.doi.org/10.1038/nbt1105-1331

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The search for a sequencing thoroughbred (2005)

Kling, Jim

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1333-1335

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Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] The Human Genome Project cost nearly $3 billion, and no one would quibble with the price tag. The scientific benefit is incalculable. But translating the potential of genomics into tangible benefits for basic and biomedical research, not to mention personalized medicine, will require vast ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1105-1333

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BiDil's impact (2005)

Puckrein, Gary ; Yancy, Clyde W.

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1343-1343

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] To the editor: We were greatly disturbed to read your editorial in the August issue (Nat. Biotechnol. 23, 903, 2005) which made disparaging comments about BiDil, a new heart failure medication for blacks that has been shown clearly to be safe and effective. Despite misleading claims in your ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1105-1343a

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Response to BiDil's impact (2005)

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1343-1344

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Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Nature Biotechnology responds to BiDil's impact: In citing their three 'crucial' facts, Puckrein and Yang sidestep the main point of our editorial: BiDil is a poor example of targeted medicine. As far as we know, skin pigmentation has not yet been genetically linked to (less still shown to be an ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1105-1343b

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Bringing safe and effective cell therapies to the bedside (2005)

Preti, Robert A

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 801-804

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] With relatively little fanfare, the current Good Tissue Practices (cGTP) Final Rule finally came into force in the United States in May. Under its legal authority, the US Food and Drug Administration (FDA) now inspects entities involved in the manufacture of human cells, tissues, and cellular and ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0705-801

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86

Digitale Medien

Response to 'On-the-fly' or 'generate-first' modeling? (2005)

Lok, Larry ; Brent, Roger

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1345-1345

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Lok and Brent respond: Our simulation program, Moleculizer, calculates cellular reaction networks by allowing protein complexes to form in silico. From the correspondence of Hlavacek and colleagues, we take two main points. They argue that there are advantages to generating reaction networks ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1105-1345

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87

Digitale Medien

A farewell to bacterial ARMs? (2005)

Rea, Philip A

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1085-1087

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] In a stroke of serendipity, researchers investigating plant responses to the explosive TNT have stumbled upon a transporter gene that may obviate the need for bacterial selectable markers in the generation of transgenic plants. As described in this issue, Mentewab and Stewart were studying the ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0905-1085

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88

Digitale Medien

Response to Molecule–kinase interaction map (2005)

Fabian, Miles A. ; Biggs, William H. ; Treiber, Daniel K. ; [weitere]

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1346-1348

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Fabian et al. respond: Buolamwini and Kamath suggest that the data presented in our manuscript lack statistical validation and are not sufficiently quantitative to justify some of our conclusions. In particular, they state that the validation of our technology, which included a detailed comparison ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1105-1346b

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89

Digitale Medien

Plant transgenic science knowledge (2005)

Vain, Philippe

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1348-1349

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] To the editor: Monitoring the evolution of plant transgenic science is hampered by the difficulty of obtaining accurate bibliometric information compared with equivalent animal and microbial research. This is mostly due to the imprecision of the term 'transformation,' which is generally used to ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1105-1348

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90

Digitale Medien

Why tissue engineering needs process engineering (2005)

Archer, Richard ; Williams, David J

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1353-1355

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Tissue engineering is having difficulty transitioning from a development-stage industry to one with a successful product portfolio. Currently, many of the key international tissue-engineering centers focus almost exclusively on the biology of tissue culture to the detriment of manufacturing and ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1105-1353

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91

Digitale Medien

Bright new world (2005)

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1357-1357

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] In Liberation Biology, Ronald Bailey grapples with many of the key ethical issues raised by our advances in biotech. He seeks to counterbalance the bleak vision of the future, akin to Huxley's Brave New World, predicted by Leon Kass, Francis Fukuyama and other 'bioconservatives.' Bailey's own ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1105-1357

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92

Digitale Medien

The number on biotech indexes (2005)

Jacobs, Tom

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1356-1356

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Those of us who invest in stocks can repeat the major indexes of market performance in our sleep because they are ubiquitous in the financial media. The S&P, FTSE, CAC, DAX and Nikkei are acronyms known worldwide for their alleged measure of the US, UK, French, German and Japanese stock ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1105-1356

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93

Digitale Medien

The business of making vaccines (2005)

Sheridan, Cormac

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1359-1366

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] The landscape in vaccine manufacturing has changed radically over the past 30 years. In 1967, over a dozen licensed vaccine manufacturers operated in the United States alone. This number has since collapsed through mergers and exits to barely a handful. Low profit margins, the introduction in 1980 ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1105-1359

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94

Digitale Medien

Protein biomarker discovery and validation: the long and uncertain path to clinical utility (2006)

Rifai, Nader ; Gillette, Michael A ; Carr, Steven A

[s.l.] : Nature Publishing Group

Nature biotechnology 24 (2006), S. 971-983

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Better biomarkers are urgently needed to improve diagnosis, guide molecularly targeted therapy and monitor activity and therapeutic response across a wide spectrum of disease. Proteomics methods based on mass spectrometry hold special promise for the discovery of novel biomarkers that might form ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1235

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95

Digitale Medien

Bioethanol needs biotech now (2006)

[s.l.] : Nature Publishing Group

Nature biotechnology 24 (2006), S. 725-725

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] The last time biofuels figured prominently on the editorial pages of this journal was July 1996. Back then, we were struck by how many biofuel projects appeared to be “solutions in search of a problem.” Ten years later, a problem has been found. Biofuels, in particular ethanol, are ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0706-725

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96

Digitale Medien

Interest heats up in gastrointestinal space (2006)

Sheridan, Cormac

[s.l.] : Nature Publishing Group

Nature biotechnology 24 (2006), S. 727-728

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] A flurry of investment activity during the first months of 2006 is evidence that some investors are waking up to the untapped market potential of a range of widely occurring gastrointestinal (GI) conditions that are as yet not well served. Companies, however, face difficult challenges because of ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0706-727

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97

Digitale Medien

Irrational exuberance? (2006)

[s.l.] : Nature Publishing Group

Nature biotechnology 24 (2006), S. 726-726

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] While biotech researchers are stepping up to increase the efficiency and reduce the environmental impact of ethanol production, investors are also doing their bit to get biofuel off the launch pad. No less than Bill Gates, entrepreneur Richard Branson, venture capital guru Vinod Khosla and ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0706-726

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98

Digitale Medien

Pipeline cherrypicking deal yields lucrative return (2006)

Ransom, John

[s.l.] : Nature Publishing Group

Nature biotechnology 24 (2006), S. 729-729

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Exelixis just presented phase 1 clinical trial data for three new kinase inhibitors at the 2006 American Society of Clinical Oncology annual meeting held in Atlanta, Georgia June 2–3. The compounds are included in a licensing and development deal with GlaxoSmithKline (GSK) that gives the ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0706-729

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99

Digitale Medien

Merck moves into biotech (2006)

Kling, Jim

[s.l.] : Nature Publishing Group

Nature biotechnology 24 (2006), S. 730-730

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] In May, Merck, one of the oldest and stodgiest pharmaceutical companies, entered the biotech arena by announcing its plans to purchase two protein manufacturing firms: GlycoFi for $400 million and Abmaxis for $80 million. Now that even the most traditional pharmaceutical companies are ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0706-730

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100

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Profile: Elliot Entis (2006)

Powell, Kendal

[s.l.] : Nature Publishing Group

Nature biotechnology 24 (2006), S. 735-735

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Anyone who has spent time with Elliot Entis, CEO and cofounder of Aqua Bounty Technologies (ABT), has heard him say that he subscribes to the “pinball theory of life.” That is, when the right people and the right ideas are bouncing around together, the combination eventually results in ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0706-735

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