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  • Nature Publishing Company
  • 1985-1989  (409)
  • 1988  (409)
  • 1
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Genetically transformed walnut plants were regenerated from somatic embryos inoculated with a disarmed Agrobacterium tumefaciens strain containing a gene encoding kanamycin resistance. Embryo subclones derived from the inoculated embryos were selected for continued embryo proliferation on ...
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  • 2
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    Nature biotechnology 6 (1988), S. 848-848 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] As with many high-tech industries, a good deal of the field now known as biotechnology got its start in California's academic institutions, nourished by leading programs in bioscience and related fields. Nevertheless, the opportunities that originally attracted biotech companies to California need ...
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  • 3
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    Nature biotechnology 6 (1988), S. 623-623 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Tell us what to do,” asks a friend deeply enmeshed in the animal patent issue on Capitol Hill. “What model should we follow?” Special interest groups with strong support in Congress are clamoring for complete prohibition. Some of these groups oppose animal engineering on basic ...
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  • 4
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    Nature biotechnology 6 (1988), S. 633-633 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The use of microorganisms as an alternative to seeds for the production of fats and oils is becoming increasingly attractive, particularly in countries where conventional starting material is in short supply. As shown in these photographs, researchers under the direction of R. Sankaran at the ...
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  • 5
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    Nature biotechnology 6 (1988), S. 638-638 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] WASHINGTON, D.C.—The U.S Patent and Trademark Office (PTO) says it was was merely going about its business. Activist Jeremy Rifkin calls the move “an arrogant abuse of power.” Researchers and biotech industry representatives applaud the decision. And Congressional response ranges ...
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  • 6
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    Nature biotechnology 6 (1988), S. 640-640 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Some time or other, every commercial enterprise winds up doing things it wants to crow about. This rooster-like impulse generally produces a flurry of press releases that all too often wither under the stony gaze of newspaper and magazine editors. Only a small fraction ever see print. As I. F. ...
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  • 7
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    Nature biotechnology 6 (1988), S. 643-643 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] WASHINGTON, D.C.—A newly formed coalition announced plans in April to “put the scientific community on notice” concerning the human genome project. The group is calling for legislation to establish a permanent bipartisan Congressional Board and an 18-member citizens' advisory ...
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  • 8
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    Nature biotechnology 6 (1988), S. 644-644 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] A novel polypeptide antibiotic that is effective against a wide variety of fungi has been discovered at the Biological Sciences Research Laboratories of Lion Corp. (Tokyo). Lion Corp., a major detergents and toiletries manufacturer, has recently diversified into Pharmaceuticals. Isolated from a ...
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  • 9
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    Nature biotechnology 6 (1988), S. 744-744 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] An emerging goal of international agricultural crop research centers is to integrate biotechnology into established breeding programs—to enhance the efficiency of those programs and to devise new crop improvement strategies as quickly as possible. Breeding programs by their very nature ...
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  • 10
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    Nature biotechnology 6 (1988), S. 455-455 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] There's a lot of confusion; we're not sure exactly what's going on,” says the marketing director for one of the major U.S. suppliers of fetal bovine serum (FBS). Serum brokers—those who collect raw fetal calf blood from agents at slaughterhouses and re-sell it to dealers—are ...
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  • 11
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    Nature biotechnology 6 (1988), S. 473-473 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] SLOUGH, U.K.—“Our main competitor is Merck,” proclaims Louis Nisbet, R&D director of Xenova Ltd., “not Celltech.” For a new biotechnology company with a staff of just 25, this statement seems little short of ludicrous. But as an indication of Xenova's scientific ...
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  • 12
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    Nature biotechnology 6 (1988), S. 474-474 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] LONDON—A survey of manpower, education, and training in U.K. biotechnology companies* has exposed both immediate and long-term concerns about whether the supply of suitable recruits will keep pace with the demand. Already in short supply are protein chemists, immunologists, plant ...
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  • 13
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    Nature biotechnology 6 (1988), S. 479-485 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] In scaling up to produce substantial quantities of a recombinant protein or a monoclonal antibody—sufficient for clinical trials and marketing—how much is enough? And how much pilot-plant or production hardware will be needed to make it? At one time, nobody involved in biotechnology ...
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  • 14
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    Nature biotechnology 6 (1988), S. 487-492 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Oceans cover 70 percent of the world's surface. Although the marine environment is vast, it is also harsh and often inaccessible. Man may no longer be a hunter-gather on land, but he certainly remains one at sea. The commercial future of harnessing the ocean's organisms and their unusual ...
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  • 15
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    Nature biotechnology 6 (1988), S. 495-501 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Last October 19, the chaos of the wild West prevailed in the financial markets. In the ensuing shoot-out on Wall Street, biotechnology stocks got caught in a cross fire. Already under-performing the S&P 400 by about 15 percent during the first three quarters of 1987, these issues were gunned ...
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  • 16
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    Nature biotechnology 6 (1988), S. 505-516 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Until recently, bioreactor makers had little reason to commercialize novel designs. Standard stirred tanks and spinner flasks were good enough, even if not the best possible. Fermentation products simply did not command profits hefty enough to justify investing in bioreactor R&D. All this has ...
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  • 17
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    Nature biotechnology 6 (1988), S. 518-523 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The reasons for the current surge of interest in mammalian cell-culture are self-evident: monoclonal antibodies (of murine, human or chimeric types) and such recombinant hormones and enzymes as tissue plasminogen activator (t-PA) and human growth hormone (hGH)1. Concern for the purity, quality, and ...
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  • 18
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    Nature biotechnology 6 (1988), S. 591-591 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Products for Molecular Biology, a new 16-page catalog from Micron Separations (MSI, West-borough, MA), features the company's full range of nylon and cellulosic membranes, including Magnagraph, a biochemically optimized nylon used as a blotting membrane; Magna nylon, a non-modified nylon; and ...
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  • 19
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    Nature biotechnology 6 (1988), S. 592-592 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The March “First Word” calling for an American Society for Biotechnology prompted our biggest reader response ever—all of it favorable. A sampling follows: To the editor: I like the idea of the formation of a new biotechnology society. I am not suggesting that people abandon ...
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  • 20
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    Nature biotechnology 6 (1988), S. 595-595 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] To the editor: Biotechnology has no society of its own. By this I mean that biotech scientists—most of whom have their home in other scientific societies (ASM, ACS, ASBC, etc.)—find that their current societies only partially fulfill their scientific needs because biotechnology is ...
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  • 21
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    Nature biotechnology 6 (1988), S. 597-597 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] To the editor: The ASB is a terrific suggestion. Perhaps the most effective function of the association would be to act as an umbrella society for the various technical societies. This might be a difficult structure to build because of the individual aspirations of each society, but the ASB could ...
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  • 22
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    Nature biotechnology 6 (1988), S. 598-598 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] To the editor: I read with interest the description by Professor Gordon J. Edlin (Bio/ Technology 6: 252, March '88) of research in the U.K. and U.S. on characterization of the X chromosome gene that determines financial genius and success, variously designated £££ or ...
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  • 23
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    Nature biotechnology 6 (1988), S. 359-359 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] OXFORD—For many biotechnologists, the carbohydate portions of glycoproteins are of considerably more nuisance than interest. In particular, they preclude the use of bacterial expression systems for proteins that cannot function properly without glycosylation. But it is the carbohydrates that ...
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  • 24
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    Nature biotechnology 6 (1988), S. 368-368 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] WASHINGTON, D.C.—The U.S. Patent and Trademark Office (PTO) is isolating biotechnology into a single examining group. The dual goals are to reduce the staggering biotech patent backlog and make the most efficient use of PTO's biotechnology expertise. Currently, most biotech-related patents ...
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  • 25
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    Nature biotechnology 6 (1988), S. 773-777 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Vaccination programs have wiped out or controlled some of this planet's most pernicious diseases. Yet despite this success, technical limitations have so far restricted the total number of commercialized human vaccines to about 20. Biotechnology, through its high-tech subunit, anti-idiotype, and ...
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  • 26
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    Nature biotechnology 6 (1988), S. 810-815 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Human leukocyte dialysates contain substances capable of affecting human immune function. A low molecular weight subfraction derived from human leukocyte dialysates, IMREG-1, has been shown to enhance cell mediated immunity, and is under clinical evaluation as an immunosupportive agent in AIDS/ARC ...
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  • 27
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Human B-cell stimulatory factor-2 (BSF-2/ IL-6) is an important cytokine regulating the growth and differentiation of cells as diverse as lymphocytes, hepatocytes, and neurons. Recently its aberrant expression has been correlated with several diseases. Starting with a previously isolated cDNA clone ...
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  • 28
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    Nature biotechnology 6 (1988), S. 816-821 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] We have developed an automated DNA sequenator using a real-time fluorescence detection method, and achieved excellent sensitivity and rapid analysis by optimizing operating conditions. The sequenator uses unicolor labeling and four-track electrophoresis. Fluoresceine isothiocyanate(FITC)-labeled ...
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  • 29
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    Nature biotechnology 6 (1988), S. 822-825 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Autoantibodies that react with cellular components occur in high frequency in patients with systemic rheumatic diseases. A novel class of “autoantibodies” that react with cellular components has been identified in normal humans and other species. Unlike the disease-associated ...
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  • 30
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    Nature biotechnology 6 (1988), S. 826-827 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Not long ago it was taken for granted that enzymes were proteins. Recent research, however, has overturned that assumption with the discovery of biocatalytic RNA and antibody molecules. The notion of catalytic RNA was born about six years ago, when Thomas Cech's research group at the University of ...
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  • 31
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    Nature biotechnology 6 (1988), S. 833-838 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Treff (Degersheim, Switzerland) offers a microfuge rack for storing 1.5 ml microfuge tubes. The precision injection-molded racks have a removable cover and hold up to 40 tubes in an upright position. Treff also offers a pipetting system. Write in 602 on Reader Service Card A computer-controlled ...
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  • 32
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    Nature biotechnology 6 (1988), S. 841-841 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] To the editor: We read (Bio/Technology 6:575–577, May '88), “Notes on Culture Media” by Jane Williams, and wish to comment on the remark concerning bovine transferrin costing compared to human transferrin. With the increasing need to eliminate fetal bovine serum in media, ...
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  • 33
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    Nature biotechnology 6 (1988), S. 626-627 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Patents issued. Some biotech patents are important enough to warrant citing simply by the name of their inventors. Such is the case with the Cohen-Boyer patents on basic genetic engineering techniques, for which Stanford University (Palo Alto, CA) received a third key patent at the end of April. ...
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  • 34
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    Nature biotechnology 6 (1988), S. 633-633 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Recombinant vaccines now being evaluated in man follow one of three basic approaches: subunit vaccines, in which a cloned gene is used to produce large amounts of a specific antigen or to predict the amino acid sequence of a synthetic peptide; live, attenuated vaccines, in which recombinant ...
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    Nature biotechnology 6 (1988), S. 634-634 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] LONDON—“Let there be light,” commanded the U.K. Department of Trade and Industry (DTI), and the hordes descended upon the University of Sussex in April to discuss methods of rapid microbiology using ATP (adenosine triphosphate) and luminescence. In the meantime, Amersham ...
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    Nature biotechnology 6 (1988), S. 646-648 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] SOUTH SAN FRANCISCO—Genentech is biotech's trend-setter in R&D, financing, marketing, and just about everything else. But whether it will prove a role model in its pioneering litigation procedures remains open to question. And in the meantime, industry experts can't quite agree on how to ...
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    Nature biotechnology 6 (1988), S. 726-727 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Moving beyond traditional separations of target compounds from their congeners, chromatographic methods are now being used to put finishing touches on recombinant products. These important final steps include removing endotoxins and other immunogenic residues and controlling the attachment of ...
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    Nature biotechnology 6 (1988), S. 728-728 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] Porton Instruments' (Tarzana, CA) on-line HPLC interface connects the company's gas-phase protein sequencer with almost any HPLC system to divert part or all of an amino acid sample to the HPLC. Write in 802 on Reader Service Card Biocompatible HPLC columns made from glass and inert plastics ...
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    Nature biotechnology 6 (1988), S. 729-733 
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    Notes: [Auszug] Applied Biosystems' Analytical Division (Ramsey, NJ) offers a new diode array absorbance detector for HPLC. The BAS 1000S performs spectral scans with a sensitivity of 0.002 AUFS with under 1 percent noise under flow conditions. Scientists can monitor the unit's four independent output channels ...
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    Nature biotechnology 6 (1988), S. 734-734 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] To the editor: I would like to update information that appears in the article on “Chromatography and Affinity Separations” (Bio/Technology 6:158–165, Feb. '88). The table on page 165 refers to hydromethylmethacrylate (HEMA) being available from various companies, but it neglects ...
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    Nature biotechnology 6 (1988), S. 472-472 
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    Notes: [Auszug] SOUTH SAN FRANCISCO—Biotech's premier R&D company is also its premier litigator. But Genentech has yet to repeat its scientific success in the courtroom: The firm has lost initial decisions in both a U.S. suit over factor VIII and a U.K. suit over tissue plasminogen activator (t-PA). And ...
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    Nature biotechnology 6 (1988), S. 524-526 
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    Notes: [Auszug] The past 20 years have seen significant improvements in mammalian-cell bioreactors for producing bio-pharmaceuticals. The main problem is that animal cells in culture generally produce small amounts of complex proteins so that large numbers of cells are needed to produce meaningful quantities. ...
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    Nature biotechnology 6 (1988), S. 529-546 
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    Notes: [Auszug] Atrial natriuretic peptide (ANP) stimulates vasodilation, fluid egress, increased glomerular filtration and salt and water excretion, and blocks the release and/or actions of several hormones, including angiotensin II, aldosterone and vasopressin. ANP levels are commonly elevated in situations of ...
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    Nature biotechnology 6 (1988), S. 559-563 
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    Notes: [Auszug] Factors influencing the efficiency of DNA delivery into suspension culture cells of Zea mays by the particle bombardment process were studied using a chimeric gene coding for the production of β–glucuronidase. Two days following bombardment with plasmid–coated microprojectiles, ...
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    Nature biotechnology 6 (1988), S. 565-570 
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    Notes: [Auszug] The 5′ signal sequence and B chain coding region were excised from preproricin cDNA and fused in frame to generate prericin B chain cDNA. Transcripts were synthesized from the pre B chain cDNA in an in vitro system driven by T7 RNA polymerase. Pre B chain mRNA microinjected into Xenopus ...
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    Notes: [Auszug] The major lignin peroxidase from carbon limited cultures of the white–rot fungus Phanerochaete chrysosporium was purified by isoelectric focusing and crystallized by the hanging drop method. The nature of the crystalline material as lignin peroxidase was established by solid–state ...
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    Nature biotechnology 6 (1988), S. 575-581 
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    Notes: [Auszug] If mammalian cells are to survive, divide, and grow outside the body, their environment must at least mimic their natural physiological surroundings. Cell culture media are responsible for carrying out most of that deception. Basal media supplemented with serum (usually fetal calf, newborn calf, ...
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    Nature biotechnology 6 (1988), S. 581-581 
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    Notes: [Auszug] Clonetics Corp.'s (San Diego, CA) serum-free keratinocyte growth medium (KGM™) is included in the company's EpiPack® kit for culturing normal human epidermal keratinocytes. KGM promotes the growth of a variety of other epithelial cell types, as well, and eliminates the cytotoxicity and ...
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    Nature biotechnology 6 (1988), S. 583-589 
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    Notes: [Auszug] TosoHaas (Philadelphia, PA) now offers QAE Toyopearl® 550C and SP Toyopearl 550C ion-exchange resins for preparative protein chromatography. The new resins have double the protein capacity—in both batch and frontal-loading operations—of the company's Toyopearl 650 resins. Rigid and ...
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    Nature biotechnology 6 (1988), S. 592-592 
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    Notes: [Auszug] To the editor: I not only approve of the suggestion to create an American Society for Biotechnology, I am very optimistic about the outcome. There are, of course, other scientific societies with biotechnology divisions. Although these serve a purpose in bringing together those researchers ...
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    Nature biotechnology 6 (1988), S. 595-595 
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    Notes: [Auszug] To the editor: I feel strongly that the membership and modus operandi of an American Society for Biotechnology should be sufficiently generic so as to encompass individuals and aspects of biotechnology from concept to commercialization. Thus, rather than model this new society on a basic science ...
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    Nature biotechnology 6 (1988), S. 351-353 
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    Notes: [Auszug] MIAMI—A more precise understanding of how genes turn on and off is essential to refining the increasingly sophisticated heterologous genetic constructions used in biotechnology, and to answering fundamental questions of multicellular differentiation. In his Feodor Lynan lecture at this year's ...
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    Nature biotechnology 6 (1988), S. 353-353 
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    Notes: [Auszug] MIAMI—Does technology drive science or vice-versa? Whichever, it is perfectly clear that without the micro-chemical instrumentation now available—protein and DNA sequencers and synthesizers—scientists would not be embarking on their most enormous journey yet—sequencing the ...
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    Nature biotechnology 6 (1988), S. 367-367 
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    Notes: [Auszug] NEW ORLEANS, La.—It never seems possible that it can get any larger, but this year's Pittsburgh Conference and Exhibition grew again, with about 800 exhibitors in 2,300 booths showing off an impressive array of high-tech gear. For those who could tear themselves away from the trade-show ...
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    Nature biotechnology 6 (1988), S. 367-367 
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    Notes: [Auszug] Left: When Advanced Genetic Sciences (Oakland, CA) first field-tested its recombinant non-ice nucleating bacterium called “Frostban” last April in Brentwood, CA, the U.S. Environmental Protection Agency (EPA) mandated the use of a “moonsuit” and a respirator. Right For die ...
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    Nature biotechnology 6 (1988), S. 368-368 
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    Notes: [Auszug] ASHRAT, Israel— Developers of an automated plant micropropagation system claim hundred-fold increases in plant tissue culture productivity. Concomitant price reductions could expand commercial micropropagation beyond low-volume, high-value ornamentals into such bread-and-butter crops as ...
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    Nature biotechnology 6 (1988), S. 369-369 
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    Notes: [Auszug] LONDON—Lipases, the somewhat unglamorous fat-degrading enzymes, have turned into potential products for both Celltech (Slough, UK) and Novo Industri A/S (Bagsvaerd, Denmark). Each company is producing a lipase by recombinant DNA technology but for very different purposes. Celltech's human ...
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    Nature biotechnology 6 (1988), S. 370-370 
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    Notes: [Auszug] WASHINGTON, D.C.—A National Academy of Sciences (NAS) panel is recommending that the federal government devote $200 million per year in new funds toward a large-scale effort to map and eventually sequence the 3 billion nucleotides within the human genome. Although the committee says ...
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    Nature biotechnology 6 (1988), S. 435-438 
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    Notes: [Auszug] Monoclonal antibody purifier. Mab-Lab is Oros Systems' (Cambridge, MA) high-speed automated system for purifying monoclonal antibodies. Using developments in artificial intelligence, chemical engineering, and biochemistry, the system can work out how best to purify a totally uncharacterized ...
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    Nature biotechnology 6 (1988), S. 440-440 
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    Notes: [Auszug] To the editor: I find myself in general agreement with the thoughtful “Last Word” editorial by Rebecca Goldburg of the Environmental Defense Fund (Bio/Technology 6:336, March '88). In response to her comments about atrazine, however, I'd like to take this opportunity to review some ...
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    Nature biotechnology 6 (1988), S. 440-440 
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    Notes: [Auszug] Figure 2 in the research paper “Gene Transfer into Sheep”(J. P. Simons et al., Bio/Technology 6:179–183, Feb. '88) was reproduced inaccurately. The correctly shaded figure, and its legend, are reproduced below. FIGURE 2 Restriction maps of microinjected constructs. A. Plasmid ...
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    Nature biotechnology 6 (1988), S. 439-439 
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    Notes: [Auszug] Microscale glassware. The Kontes (Vineland, NJ) line of microscale glassware is illustrated in a new 48-page catalog. Included are specially designed kits featuring Microflex® threaded connections and Santoprene® economy connections. Also listed are products and accessories including ...
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    Nature biotechnology 6 (1988), S. 441-441 
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    Notes: [Auszug] MAY MEETINGS May 1–6. Federation of American Societies for Experimental Biology Annual Meeting. Las Vegas, NV. Info: Gar Kaganowich, Director, Office of Public Affairs, FASEB, 9650 Rockville Pike, Bethesda, MD 20814 May 8–13. American Society for Microbiology 88th Annual Meeting. ...
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    Nature biotechnology 6 (1988), S. 237-237 
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    Notes: [Auszug] …the immortal spirit grows Like harmony in music; there is a dark Inscrutable workmanship that reconciles Discordant elements, makes them cling together In one society William Wordsworth, The Prelude Is it finally time for an American Society for Biotechnology? We think so, though the ...
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    Nature biotechnology 6 (1988), S. 239-241 
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    Notes: [Auszug] Chiron suspends EGF trials. Chiron Corp.(Emeryville, CA) has temporarily stopped its double-blind clinical trials of recombinant epidermal growth factor (EGF) against non-healing corneal defects. The company has been developing this application through its wholly owned Chiron Ophthalmics (Irvine, ...
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    Nature biotechnology 6 (1988), S. 243-244 
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    Notes: [Auszug] WASHINGTON, D.C.—Close to 400 people involved in the commercialization of agricultural biotechnology gathered here at the end of January for the first annual “AgBiotech” conference and exposition. Ann Bublitz, manager of new technology at CibaGeigy Corp. (Greensboro, NC), ...
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    Nature biotechnology 6 (1988), S. 246-247 
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    Notes: [Auszug] PHILADELPHIA—A group of young children gather around a huge model of DNA's double helix, the size of a respectable spiral staircase. Hushed, they stand in awe of Nature's majesty, and in so doing they gain a greater understanding of and affinity for biotechnology… * * * ...
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    Nature biotechnology 6 (1988), S. 249-249 
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    Notes: [Auszug] LONDON—About 70 percent of U.K. biotech R&D personnel, production specialists, and operations staff have annual salaries below £15,000. And only in marketing and sales do more than 15 percent of the employees earn above £25,000 a year. At the low end of remuneration, ...
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    Nature biotechnology 6 (1988), S. 249-250 
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    Notes: [Auszug] SAN FRANCISCO—Three somewhat tarnished biotech companies used this past January's Hambrecht and Quist Healthcare Conference as a forum to describe shiny new business strategies. In fact, the plans being adopted by California Biotechnology, Bio-Response, and Ribi ImmunoChem Research bear some ...
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    Nature biotechnology 6 (1988), S. 250-250 
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    Notes: [Auszug] Scientists at the Biological Engineering Laboratory of Teijin Ltd. (Osaka) have mass-produced chimeric antibodies that contain murine light- and heavy-chain antigen binding domains linked to human light- and heavy-chain constant regions. Since these chimerics consist largely of human sequences, ...
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    Nature biotechnology 6 (1988), S. 252-252 
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    Notes: [Auszug] NEW YORK, April 1, 2001—News leaked today from the human genome mapping project is rocking the financial district from Wall Street to Skid Row. The facts are vague, but no one close to the story seems to question the underlying truth…or its implications. As pieced together by biotech ...
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    Nature biotechnology 6 (1988), S. 255-255 
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    Notes: [Auszug] GENEVA—One of the most frequently cited expectations for biotechnology is that its enormous potential will be used to alleviate the suffering in developing countries caused by a variety of infectious diseases. Often joined to this is the promise of effecting a real transfer of the relevant ...
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    Nature biotechnology 6 (1988), S. 256-256 
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    Notes: [Auszug] WASHINGTON, D.C.—In planning for the anticipated enlarged volume of proposals to deliberately release genetically engineered organisms into the environment, officials at the Environmental Protection Agency (EPA) recently suggested decentralizing the process (see Bio/Technology ...
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    Nature biotechnology 6 (1988), S. 256-256 
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    Notes: [Auszug] WASHINGTON, D.C.—In mid-January, the U.S. General Accounting Office (GAO) quietly released Biotechnology: Role of Institutional Biosafety Committees (IBCs). Although the GAO report* is compact and its conclusions bland, it represents the most extensive survey to date of IBCs, the ...
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    Nature biotechnology 6 (1988), S. 259-264 
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    Notes: [Auszug] One rapid, easy-to-use confirmatory test for HIV antibody-positive samples employs an indirect immunofluorescence reaction, directly on a microscope slide. Right; Reaction of HIV-antibody negative specimens on HTLV-IIIb infected H-9 cells. Left: Reaction of high liters of HIV specimens on HTLV-IIIb ...
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    Nature biotechnology 6 (1988), S. 271-275 
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    Notes: [Auszug] According to a Nineteenth Century poem by John Godfrey Saxe, “It was six men of Indostan, to learning much inclined, who went to see the Elephant (though all of them were blind).” Each man judged the great beast by the part he touched first—tail, leg, trunk, ear—and each ...
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    Nature biotechnology 6 (1988), S. 266-269 
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    Notes: [Auszug] Immunoglobulins owe their rising popularity as analytical reagents to well-known characteristics: high specificity, high affinity, variety (one can produce antibodies against virtually any molecule), and stability. One can, for example, prepare antibodies that distinguish between optical or ...
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    Nature biotechnology 6 (1988), S. 276-279 
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    Notes: [Auszug] Biotech firms have been undergoing stunning growth. In personnel alone, the average company has more than doubled every year. But as firms increase in size and begin to realize profits through product sales, their initial focus on research and development must broaden to include downstream ...
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    Nature biotechnology 6 (1988), S. 280-281 
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    Notes: [Auszug] Worldwide, more than 480 companies and 125 other research organizations are actively pursuing, through biological means, improvements in seeds, plant diagnostic tests, and plants used to feed people and animals. Though more than half of these research groups are in the United States, competition ...
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    Nature biotechnology 6 (1988), S. 282-286 
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    Notes: [Auszug] Bacteria associated with the plant rhizosphere may have beneficial effects on plant growth by providing nutrients and growth factors, or by producing antibiotics and siderophores, which antagonize phytopathogenic fungi and bacteria. There is considerable experimental support for the idea that plant ...
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    Nature biotechnology 6 (1988), S. 287-290 
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    Notes: [Auszug] We describe the production of human colony stimulating factor–1 (CSF–1) in an inducible mammalian expression system that is capable of producing milligram quantities of recombinant protein. The system involves CV–1 derived cell lines that contain integrated copies of an ...
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    Nature biotechnology 6 (1988), S. 291-294 
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    Notes: [Auszug] Human interferon–α2 (IFN–α2), an 18 kD, acidic protein, human interferon–γ (IFN–γ), a 17 kD, basic protein, and the interferon–induced murine protein Mx (72 kD) were all found in aggregates when produced in genetically engineered strains of E. ...
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    Notes: [Auszug] Plasmid vectors were constructed that expressed an antigenic determinant of the glycoprotein gene of infectious hematopoietic necrosis virus (IHNV) as a fusion protein with the trpE protein of Escherichia coli. Insertion of Sau3AI fragments from the IHNV glycoprotein gene into trpE expression ...
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    Nature biotechnology 6 (1988), S. 301-304 
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    Notes: [Auszug] The adsorption of purified cellobiohydrolases (CBH I and II) and endoglucanases (EG I and II) from Trichoderma reesei strain L27 to microcrystalline cellulose (Avicel) has been studied. Scatchard analysis of the adsorption data indicated that Avicel possessed high– and low–affinity ...
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    Nature biotechnology 6 (1988), S. 307-310 
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    Notes: [Auszug] Until recently, only a few large companies enjoyed the benefits of the expensive hardware and custom-tailored programs needed for computerized analysis of biological data. Now virtually any laboratory can utilize the computer's speed and power, thanks to inexpensive personal computers (PCs) and ...
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    Nature biotechnology 6 (1988), S. 310-310 
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    Notes: [Auszug] High-level graphics software. Dynamic Object-Rendering Environment (DORÉ) software from Ardent Computer Corp. (Sunnyvale, CA) allows interactive visualization of complex data generated by supercomputer-class applications. It is the first package to integrate the computation and analysis of ...
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    Nature biotechnology 6 (1988), S. 314-321 
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    Notes: [Auszug] The Bioscreen-C microbiological analyzer from Labsystems Ltd. (Ux-bridge, U.K.) has been modified to include an incubator that is continuously adjustable from 15–55°C. Available with software programs for research on anti-microbial compounds, bioassays, and toxicity testing, Bio-screen ...
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    Nature biotechnology 6 (1988), S. 322-322 
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    Notes: [Auszug] Biochemicals produced by Incell Corp. (Milwaukee, WI) are cataloged in its 1988 product guide. Presented is a novel line of peptides including atrial natriuretic peptides, insulin-like growth factor I, somatostatin, penicillin precursors, laminin, and cyclosporins. Protected-methylated amino acids ...
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    Nature biotechnology 6 (1988), S. 323-323 
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    Notes: [Auszug] To the editor: The article on “Mammalian Cell Culture: Worldwide Activities and Markets,” (July '87) contains a factual error (in Table 1) that could negatively impact both our company image and our genetically engineered hepatitis B vaccine, “Engerix-B.” This product is ...
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    Nature biotechnology 6 (1988), S. 323-323 
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    Notes: [Auszug] The title of the table in question is “Expected Dates of Product Introduction for Selected Products that can be made by Mammalian Cell Culture.” I apologize if this may have given the impression that SmithKline's product is actually made by cell ...
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    Nature biotechnology 6 (1988), S. 323-323 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] To the editor: The article by Arthur Klausner on the DuPont automated DNA sequencer (Bio/Technology 5:1111, Nov. '87) gives an accurate description of fluorescent sequenators. We disagree, however, with the closing statement that users will have to choose between DuPont and Applied Biosys-tems for ...
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    Nature biotechnology 6 (1988), S. 323-323 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] To the editor: We were surprised that our company (formerly called Inotech Diagnostik AG) was not mentioned in the article “Immunoassays flourish in new markets” (Bio/Technology 3:551–556, June '87). By 1980, we were already marketing ELISA reagents for the detection of viruses ...
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  • 93
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    Nature biotechnology 6 (1988), S. 323-323 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] To the editor: Your articles on doing business in Japan (October '87) were particularly interesting, but I was dismayed to find no mention of the link between Carbohydrates International (CHI) and the Marubeni Corp. And this despite the fact that the arrangement of our close competitor Biocarb ...
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  • 94
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    Nature biotechnology 6 (1988), S. 324-324 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] To the editor: Your “First Word” editorial on the pathogenesis of AIDS (Dec. '87, p. 1249) is timely. It is perhaps overdue to reexamine the whole issue with more scientific scrutiny. It may appear that human immunodeficiency virus (HIV) research holds the answer to the problem of ...
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  • 95
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    Nature biotechnology 6 (1988), S. 324-324 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] To the editor: Peter Duesberg's “Challenge to the AIDS Establishment” (Bio/Technology 5:1244, Nov. '87) contains, in my opinion, several dangerous simplifications and deceptive arguments. First, Duesberg seems to find a contradiction between the fact that someone can test positive for ...
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  • 96
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    Nature biotechnology 6 (1988), S. 325-325 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] What we have here is a conflict of convention rather than an outright error. When we have consensus, we'll follow it. Readers? ...
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    Nature biotechnology 6 (1988), S. 325-325 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] To the editor: We have been concerned for some time about the developing tendency to misuse the abbreviation “rDNA” for recombinant DNA, rather than ribosomal DNA. Thus we were dismayed to see this error appear prominently in an article by S. Molin, et al. (Bio/Technology ...
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    Nature biotechnology 6 (1988), S. 325-325 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] To the editor: While I agree that trade secret protection is a viable concept in biotechnology law, I believe it is vitally important to clarify several misconceptions about patent protection that were perpetuated in “The emergence of trade secret protection in biotechnology” ...
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    Nature biotechnology 6 (1988), S. 326-326 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] APRIL MEETINGS April 4–10. UCLA Symposium on Molecular Biology of RNA. Keystone, CO. Info: UCLA Symposia, 103 Molecular Biology Institute, University of California, Los Angeles, CA 90024-1378 April 4–10. UCLA Symposium on DNA-Protein Interactions in Transcription. Keystone, CO. Info: ...
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    Nature biotechnology 6 (1988), S. 101-101 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] So fair and foul a month we have not seen. Ever since scholars of venery first presented techniques for optimizing intake of animal protein and fats in the seminar caves at Lascaux, the meeting has been the essential form of scientific communication. Organizing a good meeting remains deeply ...
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