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  • Other Sources  (279)
  • Spacecraft Design, Testing and Performance  (198)
  • Life Sciences (General)  (81)
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  • 1
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    In:  CASI
    Publication Date: 2017-07-01
    Description: No abstract available
    Keywords: Spacecraft Design, Testing and Performance
    Type: JSC-CN-37381-3 , 2016 Tri-Lateral Safety and Mission Assurance Conference; 13-15 Sep. 2016; Sagamihara; Japan
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  • 2
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    In:  CASI
    Publication Date: 2017-07-01
    Description: No abstract available
    Keywords: Spacecraft Design, Testing and Performance
    Type: JSC-CN-37381-2 , 2016 Tri-Lateral Safety and Mission Assurance Conference; 13-15 Sep. 2016; Sagamihara; Japan
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  • 3
    Publication Date: 2019-07-26
    Description: Future long duration missions outside the protection of the Earth's magnetosphere, or unshielded exposures to solar particle events, achieves total doses capable of causing cancellous bone loss. Cancellous bone loss caused by ionizing radiation occurs quite rapidly in rodents: Initially, radiation increases the number and activity of bone-resorbing osteoclasts, followed by decrease in bone forming osteoblast cells. Here we report that Dried Plum (DP) diet completely prevented cancellous bone loss caused by ionizing radiation (Figure 1). DP attenuated marrow expression of genes related to bone resorption (Figure 2), and protected the bone marrow-derived pre-osteoblasts ex vivo from total body irradiation (Figure 3). DP is known to inhibit resorption in models of aging and ovariectomy-induced osteopenia; this is the first report that dietary DP is radioprotective.
    Keywords: Life Sciences (General)
    Type: ARC-E-DAA-TN28133 , NASA Human Research Program Investigators’ Workshop (HRP IWS 2016) ; Feb 08, 2016 - Feb 11, 2016; Galveston, TX; United States
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  • 4
    Publication Date: 2019-07-19
    Description: Eight "Expedite the Processing of Experiments to Space Station" (EXPRESS) Rack facilities are located within the International Space Station (ISS) laboratories to provide standard resources and interfaces for the simultaneous and independent operation of multiple experiments within each rack. Each EXPRESS Rack provides eight Middeck Locker Equivalent locations and two drawer locations for powered experiment equipment, also referred to as sub-rack payloads. Payload developers may provide their own structure to occupy the equivalent volume of one, two, or four lockers as a single unit. Resources provided for each location include power (28 Vdc, 0-500 W), command and data handling (Ethernet, RS-422, 5 Vdc discrete, +/- 5 Vdc analog), video (NTSC/RS 170A), and air cooling (0-200 W). Each rack also provides water cooling for two locations (500W ea.), one vacuum exhaust interface, and one gaseous nitrogen interface. Standard interfacing cables and hoses are provided on-orbit. One laptop computer is provided with each rack to control the rack and to accommodate payload application software. Four of the racks are equipped with the Active Rack Isolation System to reduce vibration between the ISS and the rack. EXPRESS Racks are operated by the Payload Operations Integration Center at Marshall Space Flight Center and the sub-rack experiments are operated remotely by the investigating organization. Payload Integration Managers serve as a focal to assist organizations developing payloads for an EXPRESS Rack. NASA provides EXPRESS Rack simulator software for payload developers to checkout payload command and data handling at the development site before integrating the payload with the EXPRESS Functional Checkout Unit for an end-to-end test before flight. EXPRESS Racks began supporting investigations onboard ISS on April 24, 2001 and will continue through the life of the ISS.
    Keywords: Spacecraft Design, Testing and Performance
    Type: M16-5396 , American Society for Gravitational and Space Research (ASGSR); Oct 26, 2016 - Oct 29, 2016; Cleveland, OH; United States
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  • 5
    Publication Date: 2019-07-19
    Description: The NASA Space Launch System (SLS) vehicle is composed of four RS-25 liquid oxygen- hydrogen rocket engines in the core-stage and two 5-segment solid rocket boosters and as a result six hot supersonic plumes interact within the aft section of the vehicle during ight. Due to the complex nature of rocket plume-induced ows within the launch vehicle base during ascent and a new vehicle con guration, sub-scale wind tunnel testing is required to reduce SLS base convective environment uncertainty and design risk levels. This hot- re test program was conducted at the CUBRC Large Energy National Shock (LENS) II short-duration test facility to simulate ight from altitudes of 50 kft to 210 kft. The test program is a challenging and innovative e ort that has not been attempted in 40+ years for a NASA vehicle. This presentation discusses the various trends of base convective heat ux and pressure as a function of altitude at various locations within the core-stage and booster base regions of the two-percent SLS wind tunnel model. In-depth understanding of the base ow physics is presented using the test data, infrared high-speed imaging and theory. The normalized test design environments are compared to various NASA semi- empirical numerical models to determine exceedance and conservatism of the ight scaled test-derived base design environments. Brief discussion of thermal impact to the launch vehicle base components is also presented.
    Keywords: Spacecraft Design, Testing and Performance
    Type: M16-5594 , AIAA Young Professionals Symposium; Oct 20, 2016 - Oct 21, 2016; Huntsville, AL; United States
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  • 6
    Publication Date: 2019-07-19
    Description: Exposure to high doses of ionizing radiation produces both acute and late effects on the collagenized tissues and have profound effects on wound healing. Because of the crucial practical importance for new radioprotective agents, our study has been focused on evaluation of the efficacy of non-toxic naturally occurring compounds to protect tissue integrity against high-dose gamma radiation. Here, we demonstrate that molecular integrity of collagen may serve as a sensitive biological marker for quantitative evaluation of molecular damage to collagenized tissue and efficacy of radioprotective agents. Increasing doses of gamma radiation (0-50kGy) result in progressive destruction of the native collagen fibrils, which provide a structural framework, strength, and proper milieu for the regenerating tissue. The strategy used in this study involved the thermodynamic specification of all structural changes in collagenized matrix of skin, aortic heart valve, and bone tissue induced by different doses and conditions of g-irradiation. This study describes a simple biophysical approach utilizing the Differential Scanning Calorimetry (DSC) to characterize the structural resistance of the aortic valve matrix exposed to different doses of g-irradiation. It allows us to identify the specific response of each constituent as well as to determine the influence of the different treatments on the characteristic parameters of protein structure. We found that pyruvate, a substance that naturally occurs in the body, provide significant protection (up to 80%) from biochemical and biomechanical damage to the collagenized tissue through the effective targeting of reactive oxygen species. The recently discovered role of pyruvate in the cell antioxidant defense to O2 oxidation, and its essential constituency in the daily human diet, indicate that the administration of pyruvate-based radioprotective formulations may provide safe and effective protection from deleterious effects of ionizing radiation.
    Keywords: Life Sciences (General)
    Type: ARC-E-DAA-TN27437 , Biophysical Society Annual Meeting; Feb 27, 2016 - Mar 02, 2016; Los Angeles, CA; United States
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  • 7
    Publication Date: 2019-07-19
    Description: The NASA Engineering and Safety Center (NESC) has sponsored a Pathfinder Study to investigate how Model Based Systems Engineering (MBSE) and Model Based Engineering (MBE) techniques can be applied by NASA spacecraft development projects. The objectives of this Pathfinder Study included analyzing both the products of the modeling activity, as well as the process and tool chain through which the spacecraft design activities are executed. Several aspects of MBSE methodology and process were explored. Adoption and consistent use of the MBSE methodology within an existing development environment can be difficult. The Pathfinder Team evaluated the possibility that an "MBSE Template" could be developed as both a teaching tool as well as a baseline from which future NASA projects could leverage. Elements of this template include spacecraft system component libraries, data dictionaries and ontology specifications, as well as software services that do work on the models themselves. The Pathfinder Study also evaluated the tool chain aspects of development. Two chains were considered: 1. The Development tool chain, through which SysML model development was performed and controlled, and 2. The Analysis tool chain, through which both static and dynamic system analysis is performed. Of particular interest was the ability to exchange data between SysML and other engineering tools such as CAD and Dynamic Simulation tools. For this study, the team selected a Mars Lander vehicle as the element to be designed. The paper will discuss what system models were developed, how data was captured and exchanged, and what analyses were conducted.
    Keywords: Spacecraft Design, Testing and Performance
    Type: JSC-CN-36119 , AIAA Space 2016 Conference; Sep 13, 2016 - Sep 16, 2016; Long Beach, CA; United States
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  • 8
    Publication Date: 2019-07-19
    Description: Orbital debris in the millimeter size range can pose a hazard to current and planned spacecraft due to the high relative impact speeds in Earth orbit. Fortunately, orbital debris has a relatively short life at lower altitudes due to atmospheric effects; however, at higher altitudes orbital debris can survive much longer and has resulted in a band of high flux around 700 to 1,500 km above the surface of the Earth. While large orbital debris objects are tracked via ground based observation, little information can be gathered about small particles except by returned surfaces, which until the Orion Exploration Flight Test number one (EFT-1), has only been possible for lower altitudes (400 to 500 km). The EFT-1 crew module backshell, which used a porous, ceramic tile system with surface coatings, has been inspected post-flight for potential micrometeoroid and orbital debris (MMOD) damage. This paper describes the pre- and post-flight activities of inspection, identification and analysis of six candidate MMOD impact craters from the EFT-1 mission.
    Keywords: Spacecraft Design, Testing and Performance
    Type: JSC-CN-35493 , AIAA Annual Technical Symposium; May 06, 2016; Houston, TX; United States
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  • 9
    Publication Date: 2019-07-19
    Description: This status report corresponds to two studies tied to an animal experiment being executed at the University of California Davis (Charles Fuller's laboratory). The animal protocol uses the well-documented rat hindlimb suspension (HLS) model, to examine the relationship between cephalic fluid shifts and the regulation of intracranial (ICP) and intraocular (IOP) pressures as well as visual system structure and function. Long Evans rats are subjected to HLS durations of 7, 14, 28 and 90 days. Subgroups of the 90-day animals are studied for recovery periods of 7, 14, 28 or 90 days. All HLS subjects have age-matched cage controls. Various animal cohorts are planned for this study: young males, young females and old males. In addition to the live measures (ICP by telemetry, IOP and retinal parameters by optical coherence tomography) which are shared with the Fuller study, the specific outcomes for this study include: -Gene expression analysis of the retina -Histologic analysis - Analysis of the microvasculature of retina flat mounts by NASA's VESsel GENeration Analysis (VESGEN) Software. To date, the young male and female cohorts are being completed. Due to the need to keep technical variation to a minimum, the histologic and genomic analyses have been delayed until all samples from each cohort are available and can be processed in a single batch per cohort. The samples received so far correspond to young males sacrificed at 7,14, 28 and 90 days of HLS and at 90 days of recovery; and from young females sacrificed at 7, 14 and 28 of HLS. A complementary study titled: "A gene expression and histologic approach to the study of cerebrospinal fluid (CSF) production and outflow in hindlimb suspended rats" seeks to study the molecular components of CSF production and outflow modulation as a result of HLS, bringing a molecular and histologic approach to investigate genome wide expression changes in the arachnoid villi and choroid plexus of HLS rats compared to rats in normal posture.
    Keywords: Life Sciences (General)
    Type: JSC-CN-34661 , 2016 NASA Human Research Program Investigators'' Workshop (HRP IWS 2016); Feb 08, 2016 - Feb 11, 2016; Galveston, TX; United States
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  • 10
    Publication Date: 2019-07-19
    Description: The translational Vestibulo-Ocular Reflex (tVOR) is an important otolith-mediated response to stabilize gaze during natural locomotion. One goal of this study was to develop a measure of the tVOR using a simple hand-operated chair that provided passive vertical motion. Binocular eye movements were recorded with a tight-fitting video mask in ten healthy subjects. Vertical motion was provided by a modified spring-powered chair (swopper.com) at approximately 2 Hz (+/- 2 cm displacement) to approximate the head motion during walking. Linear acceleration was measured with wireless inertial sensors (Xsens) mounted on the head and torso. Eye movements were recorded while subjects viewed near (0.5m) and far (approximately 4m) targets, and then imagined these targets in darkness. Subjects also provided perceptual estimates of target distances. Consistent with the kinematic properties shown in previous studies, the tVOR gain was greater with near targets, and greater with vision than in darkness. We conclude that this portable chair system can provide a field measure of otolith-ocular function at frequencies sufficient to elicit a robust tVOR.
    Keywords: Life Sciences (General)
    Type: JSC-CN-34422 , Association for Research in Otolaryngology; Feb 20, 2016 - Feb 24, 2016; San Diego, CA; United States
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  • 11
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    In:  CASI
    Publication Date: 2019-07-19
    Description: How crews get into or out of their ascent vehicle has profound implications for Mars surface architecture. Extravehicular Activity (EVA) hatches and Airlocks have the benefit of relatively low mass and high Technology Readiness Level (TRL), but waste consumables with a volume depressurization for every ingress/egress. Perhaps the biggest drawback to EVA hatches or Airlocks is that they make it difficult to keep Martian dust from being tracked back into the ascent vehicle, in violation of planetary protection protocols. Suit ports offer the promise of dust mitigation by keeping dusty suits outside the cabin, but require significant cabin real estate, are relatively high mass, and current operational concepts still require an EVA hatch to get the suits outside for the first EVA, and back inside after the final EVA. This is primarily because current designs don't provide enough structural support to protect the suits from ascent/descent loads or potential thruster plume impingement. For architectures involving more than one surface element-such as an ascent vehicle and a rover or surface habitat-a retractable tunnel is an attractive option. By pushing spacesuit don/doff and EVA operations to an element that remains on the surface, ascended vehicle mass and dust can be minimized. What's more, retractable tunnels provide operational flexibility by allowing surface assets to be re-configured or built up over time. Retractable tunnel functional requirements and design concepts being developed as part of the National Aeronautics and Space Administration's (NASA) Evolvable Mars Campaign (EMC) work will add a new ingress/egress option to the surface architecture trade space.
    Keywords: Spacecraft Design, Testing and Performance
    Type: JSC-CN-33760 , IEEE Aerospace Conference; Mar 05, 2016 - Mar 12, 2016; Big Sky, MT; United States
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  • 12
    Publication Date: 2019-07-20
    Description: Space debris poses a major risk to spacecraft. In low earth orbit, impact velocities can be 10 - 11 km/s and as high as 15 km/s. For debris shield design, it would be desirable to be able to launch projectiles of known shape and mass to these velocities. The design of the proposed 10 - 11 km/sec gun uses, as a starting point, the Ames 1.28/0.22 two stage gun, which has achieved muzzle velocities of 10 - 11.3 km/sec. That gun is scaled up to a 0.3125 launch tube diameter. The gun is then optimized with respect to maximum pressures by varying the pump tube length to diameter ratio (L/D), the piston mass and the hydrogen pressure. A pump tube L/D of 36.4 is selected giving the best overall performance. Piezometric ratios for the optimized guns are found to be ~2.3, much more favorable than for more traditional two stage light gas guns, which range from 4 to 6. (The piezometric ratio for a gun is defined as the maximum projectile base pressure divided by the constant projectile base pressure which, acting over the entire barrel length, would produce the same muzzle velocity.) The maximum powder chamber pressures are 20 to 30 ksi. To reduce maximum pressures, the desirable range of the included angle of the cone of the high pressure coupling is found to be 7.3 to 14.6 degrees. Lowering the break valve rupture pressure is found to lower the maximum projectile base pressure, but to raise the maximum gun pressure. For the optimized gun with a pump tube L/D of 36.4, increasing the muzzle velocity by decreasing the projectile mass and increasing the powder loads is studied. It appears that saboted spheres could be launched to 10.25 and possibly as high as 10.8 km/sec, and that disc-like plastic models could be launched to 11.05 km/s. The use of a tantalum liner to greatly reduce bore erosion and increase muzzle velocity is discussed. With a tantalum liner, CFD code calculations predict muzzle velocities as high as 12 to 13 km/s.
    Keywords: Spacecraft Design, Testing and Performance
    Type: ARC-E-DAA-TN35142 , Aeroballistic Range Association Meeting; Oct 03, 2016 - Oct 06, 2016; Toledo; Spain
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  • 13
    Publication Date: 2019-07-20
    Description: Established research has illustrated that moderate exposure to stress in the womb influences both adult phonotype and genotype for several physiological pathways, especially in males. Proposed explanations include adaptions made by the fetus resulting from a limited supply of nutrients, referred to as the thrifty phenotype. In this study, we examine this fetal programming effect on the appetite control and energy expenditure pathways in prenatally stressed adult male offspring. Subjects were male rats born from time-mated female rats exposed to unpredictable, variable prenatal stress (UVPS) throughout gestation. An analysis of the adult male rat offspring genetic expression of epididymal fat pads and the plasma concentrations of hormones involved in appetite control and energy expenditure pathways showed a significantly diminished expression of leptin and adiponectin compared to unstressed controls. Leptin and adiponectin are both major hormones involved in the appetite control and energy expenditure pathways, with leptin regulating energy balance due to its function as an inhibitor of hunger, and adiponectin modulating glucose levels and fatty acid breakdown. We observed higher leptin concentrations within the prenatally stressed male plasma, and lower expression of leptin (OB) and adiponectin (ADIPOQ) genes from the epididymal fat pads. We suggest that elevated leptin in the plasma elicited a negative feedback effect on OB expression levels, decreasing their quantification compared to control animals. Further analysis will include plasma quantification of insulin and glucose, as well as expression of ghrelin, a peptide which acts on the central nervous system and the bodys perception of hunger.
    Keywords: Life Sciences (General)
    Type: ARC-E-DAA-TN33060 , International Society for Development Psychobiology (ISDP) Annual Meeting; Nov 09, 2016 - Nov 11, 2016; San Diego, CA; United States
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  • 14
    Publication Date: 2019-07-20
    Description: NASA STMD Centennial Challenges Program operates government prize programs for the public benefit. Cube Quest Challenge awards prizes to citizen inventors who advance CubeSat state of the art, enabling affordable NASA science and exploration missions. Cube Quest will take place in lunar orbit or at 4M km. CubeSat developers will make advancements in communications, propulsion and radiation tolerance suitable for future deep space missions. Cube Quest may inspire other ambitious government challenges.
    Keywords: Spacecraft Design, Testing and Performance
    Type: ARC-E-DAA-TN35552 , AIAA Space Forum 2016; Sep 13, 2016 - Sep 16, 2016; Long Beach, CA; United States
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  • 15
    Publication Date: 2019-07-20
    Description: From a micro-biology perspective, directed evolution is a technique that uses controlled environmental pressures to select for a desired phenotype. Directed evolution has the distinct advantage over rational design of not needing extensive knowledge of the genome or pathways associated with a microorganism to induce phenotypes. However, there are currently limitations to the applicability of this technique including being time-consuming, error-prone, and dependent on existing assays that may lack selectivity for the given phenotype. The AADEC (Autonomous Adaptive Directed Evolution Chamber) system is a proof-of-concept instrument to automate and improve the technique such that directed evolution can be used more effectively as a general bioengineering tool. A series of tests using the automated system and comparable by-hand survival assay measurements have been carried out using UV-C radiation and Escherichia coli cultures in order to demonstrate the advantages of the AADEC versus traditional implementations of directed evolution such as random mutagenesis. AADEC uses UV-C exposure as both a source of environmental stress and mutagenesis, so in order to evaluate the UV-C tolerance obtained from the cultures, a manual UV-C exposure survival assay was developed alongside the device to compare the survival fractions at a fixed dosage. This survival assay involves exposing E. coli to UV-C radiation using a custom-designed exposure hood to control the flux and dose. Surviving cells are counted then transferred to the next iteration and so on for several iterations to calculate the survival fractions for each exposure iteration.This survival assay primarily serves as a baseline for the AADEC device, allowing quantification of the differences between the AADEC system over the manual approach. The primary data of comparison is survival fractions; this is obtained by optical density and plate counts in the manual assay and by optical density growth curve fits pre- and post-exposure in the automated case. This data can then be compiled to calculate trends over the iterations to characterize increasing UV-C resistance of the E.coli strains. The observed trends are statistically indistinguishable through several iterations from both sources.
    Keywords: Life Sciences (General)
    Type: ARC-E-DAA-TN37497 , American Geophysical Union Fall Meeting (AGU 2016); Dec 12, 2016 - Dec 16, 2016; San Francisco, CA; United States
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  • 16
    Publication Date: 2019-07-19
    Description: Exposure to stress in the womb shapes neurobiological and physiological outcomes of offspring in later life, including body weight regulation and metabolic profiles. Our previous work utilizing a centrifugation-induced hypergravity demonstrated significantly increased (8-15) body mass in male, but not female, rats exposed throughout gestation to chronic 2-g from conception to birth. We reported the same outcome in adult offspring exposed throughout gestation to Unpredictable Variable Prenatal Stress (UVPS). Here we examine gene expression changes using our UVPS model to identify a potential role for prenatal stress in this hypergravity programming effect. Specifically we focused on appetite control and energy expenditure pathways in prenatally stressed adult (90-day-old) male Sprague-Dawley rats. Time-mated female rats were exposed throughout their 22-day pregnancy to UVPS consisting of white noise, strobe light, and tube restraint individually once per day on an unpredictable schedule for 15, 30 or 60 min. To control for potential changes in postnatal maternal care, newborn pups were fostered to non-manipulated, newly parturient dams. At 90-days of age, we analyzed plasma concentrations of hormones involved in appetite control and energy expenditure (leptin and adiponectin), and quantified expression of key genes in epididymal fat pads harvested from adult male offspring and controls. Leptin regulates energy balance by inhibiting hunger, and adiponectin modulates glucose levels and fatty acid breakdown. Our findings indicate significantly elevated plasma leptin concentrations and reduced expression of epididymal fat leptin (OB) and adiponectin (ADIPOQ) genes compared to controls. Analyses presently underway include quantification of plasma insulin and glucose, and the expression of ghrelin, a peptide that acts on the central nervous system and the body's perception of hunger. Collectively, these findings will further understanding of the consequences of UVPS on body weight regulation and metabolism, and provide further insight into the effect of gravity modulation on mammalian fetal development.
    Keywords: Life Sciences (General)
    Type: ARC-E-DAA-TN33631 , Annual Meeting American Society for Gravitational and Space Research (ASGSR 2016); Oct 26, 2016 - Oct 29, 2016; Cleveland, OH; United States
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  • 17
    Publication Date: 2019-07-13
    Description: In-space assembly (ISA), the ability to build structures in space, has the potential to enable or support a wide range of advanced mission capabilities. Many different individual assembly technologies would be needed in different combinations to serve many mission concepts. The many-to-many relationship between mission needs and technologies makes it difficult to determine exactly which specific technologies should receive priority for development and demonstration. Furthermore, because enabling technologies are still immature, no realistic, near-term design reference mission has been described that would form the basis for flowing down requirements for such development and demonstration. This broad applicability without a single, well-articulated mission makes it difficult to advance the technology all the way to flight readiness. This paper reports on a study that prioritized individual technologies across a broad field of possible missions to determine priority for future technology investment.
    Keywords: Spacecraft Design, Testing and Performance
    Type: NF1676L-24911 , AIAA Space 2016 Conference; Sep 13, 2016 - Sep 16, 2016; Long Beach, CA; United States
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  • 18
    Publication Date: 2019-07-13
    Description: For successful cell research, the growth culture environment must be tightly controlled. Deviance from the optimal conditions will mask the desired variable being analyzed or lead to inconstancies in the results. In standard laboratories, technology and procedures are readily available for the reliable control of variables such as temperature, pH, nutrient loading, and dissolved gases. Due to the nature of spaceflight, and the inherent constraints to engineering designs, these same elements become a challenge to maintain at stable values by both automated and manual approaches. Launch mass, volume, and power usage create significant constraints to cell culture systems; nonetheless, innovative solutions for active environmental controls are available. The acidity of the growth media cannot be measured through standard probes due to the degradation of electrodes and reliance on indicators for chromatography. Alternatively, carbon dioxide sensors are capable of monitoring the pH by leveraging the relationship between the partial pressure of carbon dioxide and carbonic acid in solution across a membrane. In microgravity cell growth systems, the gas delivery system can be used to actively maintain the media at the proper acidity by maintaining a suitable gas mixture around permeable tubing. Through this method, launch mass and volume are significantly reduced through the efficient use of the limited gas supply in orbit.
    Keywords: Life Sciences (General)
    Type: ARC-E-DAA-TN36807 , Annual Meeting of the American Society for Gravitational and Space Research (ASGSR); Oct 26, 2016 - Oct 29, 2016; Cleveland, OH; United States
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  • 19
    Publication Date: 2019-07-13
    Description: Exposure to stress in the womb shapes neurobiological and physiological outcomes of offspring in later life, including body weight regulation and metabolic profiles. Our previous work utilizing a centrifugation-induced hyper-gravity demonstrated significantly increased (8-15%) body mass in male, but not female, rats exposed throughout gestation to chronic 2-g from conception to birth. We reported a similar outcome in adult offspring exposed throughout gestation to Unpredictable Variable Prenatal Stress (UVPS). Here we examine gene expression changes and the plasma of animals treated with our UVPS model to identify a potential role for prenatal stress in this hypergravity programming effect. Specifically we focused on appetite control and energy expenditure pathways in prenatally stressed adult (90-day-old) male Sprague-Dawley rats.
    Keywords: Life Sciences (General)
    Type: ARC-E-DAA-TN36744 , Annual Meeting of the American Society of Gravitational and Space Research (ASGSR) 2016; Oct 26, 2016 - Oct 29, 2016; Cleveland, OH; United States
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  • 20
    Publication Date: 2019-07-13
    Description: Mechanical unloading during spaceflight is known to adversely affect mammalian physiology. Our previous studies using the Animal Enclosure Module on short duration Shuttle missions enabled us to identify a deficit in stem cell based-tissue regeneration as being a significant concern for long-duration spaceflight. Specifically, we found that mechanical unloading in microgravity resulted in inhibition of differentiation of mesenchymal and hematopoietic stem cells in the bone marrow compartment. Also, we observed overexpression of a cell cycle arrest molecule, CDKN1ap21, in osteoprecursor cells on the bone surface, chondroprogenitors in the articular cartilage, and in myofibers attached to bone tissue. Specifically in bone tissue during both short (15-day) and long (30-day) microgravity experiments, we observed significant loss of bone tissue and structure in both the pelvis and the femur. After 15-days of microgravity on STS-131, pelvic ischium displayed a 6.23 decrease in bone fraction (p0.005) and 11.91 decrease in bone thickness (p0.002). Furthermore, during long-duration spaceflight we observed onset of an accelerated aging-like phenotype and osteoarthritic disease state indicating that stem cells within the bone tissue fail to repair and regenerate tissues in a normal manner, leading to drastic tissue alterations in response to microgravity. The Rodent Research Hardware System provides the capability to investigate these effects during long-duration experiments on the International Space Station. During the Rodent Research-1 mission 10 16-week-old female C57Bl6J mice were exposed to 37-days of microgravity. All flight animals were euthanized and frozen on orbit for future dissection. Ground (n10) and vivarium controls (n10) were housed and processed to match the flight animal timeline. During this study we collected pelvis, femur, and tibia from all animal groups to test the hypothesis that stem cell-based tissue regeneration is significantly altered after 37-days of spaceflight. To do this, we will analyze differences in bone morphometric parameters using MicroCT. The pelvis, femur, and tibia are key in supporting and distributing weight under normal conditions. Therefore, we expect to see altered remodeling in flight animals in response to microgravity with respect to ground controls. In combination with histomorphometry, these results will help elucidate the complex mechanisms underlying bone tissue maintenance and stem cell regeneration.
    Keywords: Life Sciences (General)
    Type: ARC-E-DAA-TN36752 , Annual Meeting of the American Society for Gravitational and Space Research (ASGSR); Oct 26, 2016 - Oct 29, 2016; Cleveland, OH; United States
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  • 21
    Publication Date: 2019-07-13
    Description: During adaptation to the microgravity environment, adult mammals experience stress mediated by the Hypothalamic-Pituitary-Adrenal axis. In our previous studies of pregnant rats exposed to 2-g hypergravity via centrifugation, we reported decreased corticosterone and increased body mass and leptin in adult male, but not female, offspring. In this study, we utilized Unpredictable Variable Prenatal Stress to simulate the stressors of spaceflight by exposing dams to different stressors. Stress response modulation occurs via both positive and negative feedback in the hypothalamus, anterior pituitary gland, and adrenal cortex resulting in the differential release of corticosterone (CORT), a murine analog to human cortisol.
    Keywords: Life Sciences (General)
    Type: ARC-E-DAA-TN36746 , Annual Meeting of the American Society for Gravitational and Space Research (ASGSR); Oct 26, 2016 - Oct 29, 2016; Cleveland, OH; United States
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  • 22
    Publication Date: 2019-07-13
    Description: As interest in long duration effects of space habitation increases, understanding the behavior of model organisms living within the habitats engineered to fly them is vital for designing, validating, and interpreting future spaceflight studies. A handful of papers have previously reported behavior of mice and rats in the weightless environment of space. The Rodent Research Hardware and Operations Validation (Rodent Research-1; RR1) utilized the Rodent Habitat (RH) developed at NASA Ames Research Center to fly mice on the ISS (International Space Station). Ten adult (16-week-old) female C57BL/6 mice were launched on September 21st, 2014 in an unmanned Dragon Capsule, and spent 37 days in microgravity. Here we report group behavioral phenotypes of the RR1 Flight (FLT) and environment-matched Ground Control (GC) mice in the Rodent Habitat (RH) during this long-duration flight. Video was recorded for 33 days on the ISS, permitting daily assessments of overall health and well-being of the mice, and providing a valuable repository for detailed behavioral analysis. We previously reported that, as compared to GC mice, RR1 FLT mice exhibited the same range of behaviors, including eating, drinking, exploration, self- and allo-grooming, and social interactions at similar or greater levels of occurrence. Overall activity was greater in FLT as compared to GC mice, with spontaneous ambulatory behavior, including organized 'circling' or 'race-tracking' behavior that emerged within the first few days of flight following a common developmental sequence, and comprised the primary dark cycle activity persisting throughout the remainder of the experiment. Participation by individual mice increased dramatically over the course of the flight. Here we present a detailed analysis of 'race-tracking' behavior in which we quantified: (1) Complete lap rotations by individual mice; (2) Numbers of collisions between circling mice; (3) Lap directionality; and (4) Recruitment of mice into a group phenotype. This analysis contributes to the first NASA long-duration study of rodent behavior, providing evidence for the emergence of a distinctive, organized group behavior unique to the weightless space environment.
    Keywords: Life Sciences (General)
    Type: ARC-E-DAA-TN36632 , Annual Meeting of the American Society for Gravitational and Space Research (ASGSR 2016); Oct 26, 2016 - Oct 29, 2016; Cleveland, OH; United States
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  • 23
    Publication Date: 2019-07-13
    Description: Venation patterning in leaves is a major determinant of photosynthesis efficiency because of its dependency on vascular transport of photo-assimilates, water, and minerals. Arabidopsis thaliana grown in microgravity show delayed growth and leaf maturation. Gene expression data from the roots, hypocotyl, and leaves of A. thaliana grown during spaceflight vs. ground control analyzed by Affymetrix microarray are available through NASA's GeneLab (GLDS-7). We analyzed the data for differential expression of genes in leaves resulting from the effects of spaceflight on vascular patterning. Two genes were found by preliminary analysis to be up-regulated during spaceflight that may be related to vascular formation. The genes are responsible for coding an ARGOS (Auxin-Regulated Gene Involved in Organ Size)-like protein (potentially affecting cell elongation in the leaves), and an F-box/kelch-repeat protein (possibly contributing to protoxylem specification). Further analysis that will focus on raw data quality assessment and a moderated t-test may further confirm up-regulation of the two genes and/or identify other gene candidates. Plants defective in these genes will then be assessed for phenotype by the mapping and quantification of leaf vascular patterning by NASA's VESsel GENeration (VESGEN) software to model specific vascular differences of plants grown in spaceflight.
    Keywords: Life Sciences (General)
    Type: ARC-E-DAA-TN36715 , Annual Meeting of the American Society for Gravitational and Space Research (ASGSR 2016); Oct 26, 2016 - Oct 29, 2016; Cleveland, OH; United States
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  • 24
    Publication Date: 2019-07-13
    Description: No abstract available
    Keywords: Spacecraft Design, Testing and Performance
    Type: JSC-CN-37509 , Annual Association of Space Explorers Congress; Oct 03, 2016 - Oct 07, 2016; Vienna; Austria
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  • 25
    Publication Date: 2019-07-13
    Description: The goal of interface management is to identify, define, control, and verify interfaces; ensure compatibility; provide an efficient system development; be on time and within budget; while meeting stakeholder requirements. This paper will present a successful seven-step approach to interface management used in several NASA flight projects. The seven-step approach using Model Based Systems Engineering will be illustrated by interface examples from the Materials International Space Station Experiment-X (MISSE-X) project. The MISSE-X was being developed as an International Space Station (ISS) external platform for space environmental studies, designed to advance the technology readiness of materials and devices critical for future space exploration. Emphasis will be given to best practices covering key areas such as interface definition, writing good interface requirements, utilizing interface working groups, developing and controlling interface documents, handling interface agreements, the use of shadow documents, the importance of interface requirement ownership, interface verification, and product transition.
    Keywords: Spacecraft Design, Testing and Performance
    Type: NF1676L-22935 , Annual INCOSE International Symposium (IS 2016); Jul 18, 2016 - Jul 21, 2016; Edinburgh; United Kingdom
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  • 26
    Publication Date: 2019-07-13
    Description: No abstract available
    Keywords: Life Sciences (General)
    Type: JSC-CN-37455 , International Astronautical Congress (IAC); Sep 26, 2016 - Sep 30, 2016; Guadalajara; Mexico
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  • 27
    Publication Date: 2019-07-13
    Description: This work describes the direct simulation Monte Carlo (DSMC) investigation of Saturn entry probe scenarios and the influence of non-equilibrium phenomena on Saturn entry conditions. The DSMC simulations coincide with rarefied hypersonic shock tube experiments of a hydrogen-helium mixture performed in the Electric Arc Shock Tube (EAST) at the NASA Ames Research Center. The DSMC simulations are post-processed through the NEQAIR line-by-line radiation code to compare directly to the experimental results. Improved collision cross-sections, inelastic collision parameters, and reaction rates are determined for a high temperature DSMC simulation of a 7-species H2-He mixture and an electronic excitation model is implemented in the DSMC code. Simulation results for 27.8 and 27.4 km/s shock waves are obtained at 0.2 and 0.1 Torr, respectively, and compared to measured spectra in the VUV, UV, visible, and IR ranges. These results confirm the persistence of non-equilibrium for several centimeters behind the shock and the diffusion of atomic hydrogen upstream of the shock wave. Although the magnitude of the radiance did not match experiments and an ionization inductance period was not observed in the simulations, the discrepancies indicated where improvements are needed in the DSMC and NEQAIR models.
    Keywords: Spacecraft Design, Testing and Performance
    Type: NF1676L-23810 , AIAA Aviation 2016; Jun 13, 2016 - Jun 17, 2016; Washington, DC; United States
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  • 28
    Publication Date: 2019-07-13
    Description: At the end of James Webb Space Telescope (JWST) OTIS (Optical Telescope Element-OTE-Integrated Science Instrument Module-ISIM) cryogenic vacuum testing in NASA Johnson Space Centers (JSCs) thermal vacuum (TV) Chamber A, contamination control (CC) engineers are mooting the idea that chamber particulate material stirred up by the repressurization process may be kept from falling into the ISIM interior to some degree by activating instrument purge flows over some initial period before opening the chamber valves. This memo describes development of a series of models designed to describe this process. These are strung together in tandem to estimate overpressure evolution from which net outflow velocity behavior may be obtained. Creeping flow assumptions are then used to determine the maximum particle size that may be kept suspended above the ISIM aperture, keeping smaller particles from settling within the instrument module.
    Keywords: Spacecraft Design, Testing and Performance
    Type: GSFC-E-DAA-TN34704 , Systems Contamination: Prediction, Control, and Performance 2016; Aug 28, 2016 - Sep 01, 2016; San Diego, CA; United States
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  • 29
    Publication Date: 2019-07-13
    Description: Program to Optimize Simulated Trajectories II (POST2) was utilized to develop trajectory simulations characterizing all flight phases from drop to splashdown for the Low-Density Supersonic Decelerator (LDSD) project's first and second Supersonic Flight Dynamics Tests (SFDT-1 and SFDT-2) which took place June 28, 2014 and June 8, 2015, respectively. This paper describes the modeling improvements incorporated into the LDSD POST2 simulations since SFDT-1 and presents how these modeling updates affected the predicted SFDT-2 performance and sensitivity to the mission design. The POST2 simulation flight dynamics support during the SFDT-2 launch, operations, and recovery is also provided.
    Keywords: Spacecraft Design, Testing and Performance
    Type: AAS Paper 16-221 , NF1676L-22644 , AAS/AIAA Space Flight Mechanics Meeting; Feb 14, 2016 - Feb 18, 2016; Napa, CA; United States
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  • 30
    Publication Date: 2019-07-13
    Description: The Tethered Satellite System (TSS) Space Shuttle missions, TSS-1 in 1993 and TSS-1R in 1996, were the height of space tether technology development in the U.S. Altogether, the investment made by NASA and the Italian Space Agency (ASI) over the thirteen-year period of the TSS Program totaled approximately $400M-exclusive of the two Space Shuttle flights provided by NASA. Since those two pioneering missions, there have been several smaller tether flight experiments, but interest in this promising technology has waned within NASA as well as the DOD agencies. This is curious in view of the unique capabilities of space tether systems and the fact that they have been flight validated in earth orbit and shown to perform better than the preflight dynamic or electrodynamic theoretical predictions. While it is true that the TSS-1 and TSS-1R missions experienced technical difficulties, the causes of these early developmental problems are now known to have been engineering design flaws, material selection, and procedural issues that (1) are unrelated to the basic viability of space tether technology, and (2) can be readily corrected. The purpose of this paper is to review the dynamic and electrodynamic fundamentals of space tethers and the unique capabilities they afford (that are enabling to certain types of space missions); to elucidate the nature, cause, and solution of the early developmental problems; and to provide an update on progress made in development of the technology.
    Keywords: Spacecraft Design, Testing and Performance
    Type: M16-5298 , International Conference on Tethers in Space; May 24, 2016 - May 26, 2016; Ann Arbor, MI; United States
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  • 31
    Publication Date: 2019-07-13
    Description: No abstract available
    Keywords: Spacecraft Design, Testing and Performance
    Type: AIAA SciTech Conference; Jan 04, 2016 - Jan 08, 2016; San Diego, CA; United States
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  • 32
    Publication Date: 2019-07-13
    Description: Human-scale landers require the delivery of much heavier payloads to the surface of Mars than is possible with entry, descent, and landing (EDL) approaches used to date. A conceptual design was developed for a 10 m diameter crewed Mars lander with an entry mass of approx.75 t that could deliver approx.28 t of useful landed mass (ULM) to a zero Mars areoid, or lower, elevation. The EDL design centers upon use of a high ballistic coefficient blunt-body entry vehicle and throttled supersonic retro-propulsion (SRP). The design concept includes a 26 t Mars Ascent Vehicle (MAV) that could support a crew of 2 for approx.24 days, a crew of 3 for approx.16 days, or a crew of 4 for approx.12 days. The MAV concept is for a fully-fueled single-stage vehicle that utilizes a single pump-fed 250 kN engine using Mono-Methyl Hydrazine (MMH) and Mixed Oxides of Nitrogen (MON-25) propellants that would deliver the crew to a low Mars orbit (LMO) at the end of the surface mission. The MAV concept could potentially provide abort-to-orbit capability during much of the EDL profile in response to fault conditions and could accommodate return to orbit for cases where the MAV had no access to other Mars surface infrastructure. The design concept for the descent stage utilizes six 250 kN MMH/MON-25 engines that would have very high commonality with the MAV engine. Analysis indicates that the MAV would require approx.20 t of propellant (including residuals) and the descent stage would require approx.21 t of propellant. The addition of a 12 m diameter supersonic inflatable aerodynamic decelerator (SIAD), based on a proven flight design, was studied as an optional method to improve the ULM fraction, reducing the required descent propellant by approx.4 t.
    Keywords: Spacecraft Design, Testing and Performance
    Type: AIAA SciTech Conference; Jan 04, 2016 - Jan 08, 2016; San Diego, CA; United States
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  • 33
    Publication Date: 2019-07-13
    Description: Information on nest temperatures of the American Alligator (Alligator mississippiensis) constructed in the wild is limited. Nesting temperatures during a critical thermal sensitive period determine the sex of alligators and are therefore critical in establishing the sex biases in recruitment efforts of alligators within a given community. Nest components, varying environmental conditions, and global warming could have a significant impact on nest temperatures, thus affecting future generations of a given population. One hundred and seventy four programmable thermistors were inserted into fifty eight nests from 2010 through 2015 nesting cycles. Three thermistors were placed inside each nest cavity (one on top of the eggs, one in the middle of the eggs, and one at the bottom of the clutch of the eggs) to collect temperature profiles in the incubation chamber and throughout the entire incubation period. One thermistor was also placed near or above these nests to obtain an ambient air temperature profile. Once retrieved, data from these thermistors were downloaded to examine temperature profiles throughout the incubation period as well as during the period of sexual determination. These data would help establish survival rates related to nest temperature and predict sex ratio of recruited neonates at the Kennedy Space Center. Over three million temperatures have been recorded since 2010 for the alligator thermistor study giving us insight to the recruitment efforts found here. Precipitation was the largest influence on nesting temperatures outside of daily photoperiod, with immediate changes of up to eight degrees Celsius.
    Keywords: Life Sciences (General)
    Type: KSC-E-DAA-TN31423 , Working Meeting of the Crocodile Specialist Group; May 23, 2016 - May 27, 2016; Sakuza; South Africa
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  • 34
    Publication Date: 2019-07-13
    Description: Growing vegetable crops in space will be an essential part of sustaining astronauts during long-range missions. To drive photosynthesis, red and blue light-emitting diodes (LEDs) have attracted attention because of their efficiency, longevity, small size, and safety. In efforts to optimize crop yield, there is also recent interest in analyzing the subtle effects of additional wavelengths on plant growth. For instance, since plants often look purplish gray under red and blue LEDs, the addition of green light allows easy recognition of disease and the assessment of plant health status. However, it is important to know if wavelengths outside the traditional red and blue wavebands have a direct effect on enhancing or hindering the mechanisms involved in plant growth. In this experiment, a comparative study was performed on two short cycle crops of red romaine lettuce (Lactuca sativa cv. "Outredgeous") and radish (Raphanus sativa cv. 'Cherry Bomb'), which were grown under two light treatments. The first treatment being red (630 nm) and blue (450 nm) LEDs alone, while the second treatment consisted of daylight tri-phosphor fluorescent lamps (CCT approximately 5000 K) at equal photosynthetic photon flux (PPF). The treatment effects were evaluated by measuring the fresh biomass produced, plant morphology and leaf dimensions, leaf chlorophyll content, and adenosine triphosphate (ATP) within plant leaf/storage root tissues.
    Keywords: Life Sciences (General)
    Type: KSC-E-DAA-TN30693 , International Symposium on Light in Horticulture; May 22, 2016 - May 26, 2016; East Lansing, MI; United States
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  • 35
    Publication Date: 2019-07-13
    Description: The heritage thermal model for the full STO-2 (Stratospheric Terahertz Observatory II), vehicle has been updated to model the CSBF (Columbia Scientific Balloon Facility) SIP-14 (Scientific Instrument Package) in detail. Analysis of this model has been performed for the Antarctica FY2017 launch season. Model temperature predictions are compared to previous results from STO-2 review documents.
    Keywords: Spacecraft Design, Testing and Performance
    Type: GSFC-E-DAA-TN32099 , The Scientific Ballooning Technologies Workshop; May 09, 2016 - May 11, 2016; Minneapolis, MN; United States
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  • 36
    Publication Date: 2019-07-13
    Description: The Columbia Scientific Balloon Facility is responsible for ensuring that science payloads meet the appropriate design requirements. The ultimate goal is to ensure that payloads stay within the allowable launch limits as well as survive the termination event. The purpose of this presentation is to provide some general guidelines for Gondola Design. These include rules and reasons on why CSBF has a certain preference and location for certain components within the gondola as well as other suggestions. Additionally, some recommendations are given on how to avoid common pitfalls.
    Keywords: Spacecraft Design, Testing and Performance
    Type: GSFC-E-DAA-TN32080 , The Scientific Ballooning Technologies Workshop; May 09, 2016 - May 11, 2016; Minneapolis, MN; United States
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  • 37
    Publication Date: 2019-07-13
    Description: The In-Space Manufacturing (ISM) project at NASA Marshall Space Flight Center currently operates a 3D FDM (fused deposition modeling) printer onboard the International Space Station. In order to enable utilization of this capability by designer, the project needs to establish characteristic material properties for materials produced using the process. This is difficult for additive manufacturing since standards and specifications do not yet exist for these technologies. Due to availability of crew time, there are limitations to the sample size which in turn limits the application of the traditional design allowables approaches to develop a materials property database for designers. In this study, various approaches to development of material databases were evaluated for use by designers of space systems who wish to leverage in-space manufacturing capabilities. This study focuses on alternative statistical techniques for baseline property development to support in-space manufacturing.
    Keywords: Spacecraft Design, Testing and Performance
    Type: M16-4922 , The Minerals, Metals and Materials Society (TMS) 2016 Annual Meeting and Exhibition; Feb 14, 2016 - Feb 18, 2016; Nashville, TN; United States
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  • 38
    Publication Date: 2019-07-13
    Description: Although spacecraft developers have been moving towards standardized product lines as the aerospace industry has matured, NASA's continual need to push the cutting edge of science to accomplish unique, challenging missions can still lead to spacecraft resource growth over time. This paper assesses historical mass, power, cost, and schedule growth for multiple NASA spacecraft from the last twenty years and compares to industry reserve guidelines to understand where the guidelines may fall short. Growth is assessed from project start to launch, from the time of the preliminary design review (PDR) to launch and from the time of the critical design review (CDR) to launch. Data is also assessed not just at the spacecraft bus level, but also at the subsystem level wherever possible, to help obtain further insight into possible drivers of growth. Potential recommendations to minimize spacecraft mass, power, cost, and schedule growth for future missions are also discussed.
    Keywords: Spacecraft Design, Testing and Performance
    Type: GSFC-E-DAA-TN28907 , 2016 IEEE Aerospace Conference; Mar 05, 2016 - Mar 12, 2016; Big Sky, MT; United States
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  • 39
    Publication Date: 2019-07-13
    Description: Over a decade of work has been conducted in the development of NASA's Hypersonic Inflatable Aerodynamic Decelerator (HIAD) deployable aeroshell technology. This effort has included multiple ground test campaigns and flight tests culminating in the HIAD project's second generation (Gen-2) aeroshell system. The HIAD project team has developed, fabricated, and tested stacked-torus inflatable structures (IS) with flexible thermal protection systems (F-TPS) ranging in diameters from 3-6m, with cone angles of 60 and 70 deg. To meet NASA and commercial near term objectives, the HIAD team must scale the current technology up to 12-15m in diameter. The HIAD project's experience in scaling the technology has reached a critical juncture. Growing from a 6m to a 15m class system will introduce many new structural and logistical challenges to an already complicated manufacturing process. Although the general architecture and key aspects of the HIAD design scale well to larger vehicles, details of the technology will need to be reevaluated and possibly redesigned for use in a 15m-class HIAD system. These include: layout and size of the structural webbing that transfers load throughout the IS, inflatable gas barrier design, torus diameter and braid construction, internal pressure and inflation line routing, adhesives used for coating and bonding, and F-TPS gore design and seam fabrication. The logistics of fabricating and testing the IS and the F-TPS also become more challenging with increased scale. Compared to the 6m aeroshell (the largest HIAD built to date), a 12m aeroshell has four times the cross-sectional area, and a 15m one has over six times the area. This means that fabrication and test procedures will need to be reexamined to account for the sheer size and weight of the aeroshell components. This will affect a variety of steps in the manufacturing process, such as: stacking the tori during assembly, stitching the structural webbing, initial inflation of tori, and stitching of F-TPS gores. Additionally, new approaches and hardware will be required for handling and ground testing of both individual tori and the fully assembled HIADs. There are also noteworthy benefits of scaling up the HIAD aeroshell to 15m-class system. Two complications in working with handmade textiles structures are the non-linearity of the materials and the role of human accuracy during fabrication. Larger, more capable, HIAD structures should see much larger operational loads, potentially bringing the structural response of the materials out of the non-linear regime and into the preferred linear response range. Also, making the reasonable assumption that the magnitude of fabrication accuracy remains constant as the structures grow, the relative effect of fabrication errors should decrease as a percentage of the textile component size. Combined, these two effects improve the predictive capability and the uniformity of the structural response for a 12-15m class HIAD. In this paper, the challenges and associated mitigation plans related to scaling up the HIAD stacked-torus aeroshell to a 15m class system will be discussed. In addition, the benefits of enlarging the structure will be further explored.
    Keywords: Spacecraft Design, Testing and Performance
    Type: ARC-E-DAA-TN29077 , IEEE Aerospace Conference; Mar 05, 2016 - Mar 12, 2016; Big Sky, MT; United States
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  • 40
    Publication Date: 2019-07-13
    Description: The Deep Space Climate Observatory (DSCOVR), formerly known as Triana, successfully launched on February 11th, 2015. To date, each of the five space-craft attitude control system (ACS) modes have been operating as expected and meeting all guidance, navigation, and control (GN&C) requirements, although since launch, several anomalies were encountered. While unplanned, these anomalies have proven to be invaluable in developing a deeper understanding of the ACS, and drove the design of three alterations to the ACS task of the flight software (FSW). An overview of the GN&C subsystem hardware, including re-furbishment, and ACS architecture are introduced, followed by a chronological discussion of key events, flight performance, as well as anomalies encountered by the GN&C team.
    Keywords: Spacecraft Design, Testing and Performance
    Type: GSFC-E-DAA-TN29027 , AAS Guidance, Navigation and Control Conference; Feb 05, 2016 - Feb 10, 2016; Breckenridge, CO; United States
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  • 41
    Publication Date: 2019-07-13
    Description: The Space Power Facility at NASA's Plum Brook Station houses the world's largest and most powerful space environment simulation facilities, including the Mechanical Vibration Facility (MVF), which offers the world's highest-capacity multi-axis spacecraft shaker system. The MVF was designed to perform sine vibration testing of a Crew Exploration Vehicle (CEV)-class spacecraft with a total mass of 75,000 pounds, center of gravity (cg) height above the table of 284 inches, diameter of 18 feet, and capability of 1.25 gravity units peak acceleration in the vertical and 1.0 gravity units peak acceleration in the lateral directions. The MVF is a six-degree-of-freedom, servo-hydraulic, sinusoidal base-shake vibration system that has the advantage of being able to perform single-axis sine vibration testing of large structures in the vertical and two lateral axes without the need to reconfigure the test article for each axis. This paper discusses efforts to extend the MVF's capabilities so that it can also be used to determine fixed base modes of its test article without the need for an expensive test-correlated facility simulation.
    Keywords: Spacecraft Design, Testing and Performance
    Type: GRC-E-DAA-TN27472 , International Modal Analysis Conference; Jan 25, 2016 - Jan 28, 2016; Orlando, FL; United States
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  • 42
    Publication Date: 2019-07-13
    Description: NASA possesses a large quantity of flammability data performed in ISS airlock (30% Oxygen 526mmHg) and ISS cabin (24.1% Oxygen 760 mmHg) conditions. As new programs develop, other oxygen and pressure conditions emerge. In an effort to apply existing data, the question arises: Do equivalent oxygen partial pressures perform similarly with respect to flammability? This paper evaluates how material flammability performance is impacted from both the Maximum Oxygen Concentration (MOC) and Maximum Total Pressures (MTP) perspectives. From these studies, oxygen partial pressures can be compared for both the MOC and MTP methods to determine the role of partial pressure in material flammability. This evaluation also assesses the influence of other variables on flammability performance. The findings presented in this paper suggest flammability is more dependent on oxygen concentration than equivalent partial pressure.
    Keywords: Spacecraft Design, Testing and Performance
    Type: JSC-CN-34845 , International Symposium on Flammability and Sensitivity of Materials in Oxygen-Enriched Atmospheres; Apr 13, 2016 - Apr 15, 2016; San Antonio, TX; United States
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  • 43
    Publication Date: 2019-07-13
    Description: A two-phase brushless DC motor (BDCM) with pulse-width modulated (PWM) voltage drive is simulated to control the flywheel speed of a control moment gyroscope (CMG). An overview of a double-gimballed control moment gyroscope (DGCMG) assembly is presented along with the CMG torque effects on the spacecraft. The operating principles of a two-phase brushless DC motor are presented and the system's electro-mechanical equations of motion are developed for the root-mean-square (RMS) currents and wheel speed. It is shown that the system is an extremely "stiff" set of first-order equations for which an implicit Euler integrator is required for a stable solution. An adaptive proportional voltage controller is presented which adjusts the PWM voltages depending on several control modes for speed, current, and torque. The simulation results illustrate the interaction between the electrical system and the load dynamics and how these influence the overall performance of the system. As will be shown, the CMG spin motor model can directly provide electrical power use and thermal power output to spacecraft subsystems for effective (average) calculations of CMG power consumption.
    Keywords: Spacecraft Design, Testing and Performance
    Type: JSC-CN-34792 , AIAA SciTech 2016; Jan 04, 2016 - Jan 08, 2016; San Diego, CA; United States
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  • 44
    Publication Date: 2019-07-12
    Description: Second-throat diffusers serve to isolate rocket engines from the effects of ambient back pressure. As one of the nation's largest rocket testing facilities, the performance and design limitations of diffusers are of great interest to NASA's Stennis Space Center. This paper describes a series of tests conducted on four diffuser configurations to better understand the effects of inlet geometry and throat area on starting behavior and boundary layer separation. The diffusers were tested for a duration of five seconds with a 1455-pound thrust, LO2/GH2 thruster to ensure they each reached aerodynamic steady state. The effects of a water spray ring at the diffuser exits and a water-cooled deflector plate were also evaluated. Static pressure and temperature measurements were taken at multiple axial locations along the diffusers, and Computational Fluid Dynamics (CFD) simulations were used as a tool to aid in the interpretation of data. The hot combustion products were confirmed to enable the diffuser start condition with tighter second throats than predicted by historical cold-flow data or the theoretical normal shock method. Both aerodynamic performance and heat transfer were found to increase with smaller diffuser throats. Spray ring and deflector cooling water had negligible impacts on diffuser boundary layer separation. CFD was found to accurately capture diffuser shock structures and full-flowing diffuser wall pressures, and the qualitative behavior of heat transfer. However, the ability to predict boundary layer separated flows was not consistent.
    Keywords: Spacecraft Design, Testing and Performance
    Type: NASA/TM-2016-219221
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  • 45
    Publication Date: 2019-07-12
    Description: The Project Management and Engineering Branch (SF4) supports the Human Health and Performance Directorate (HH&P) and is responsible for developing and supporting human systems hardware for the International Space Station (ISS). When a principal investigator's (PI) medical research project on the ISS is accepted, SF4 develops the necessary hardware and software to transport to the ISS. The two projects I primarily worked on were the centrifuge and ultrasound projects. Centrifuge: One concern with spacecraft such as the ISS is electromagnetic interference (EMI) from onboard equipment, typically from radio waves (frequencies of ~3 kHz to ~300 GHz), which can negatively affect nearby circuitry. Standard commercial centrifuges produce EMI above safety limits, so my task was to help reduce EMI production from this equipment. Two centrifuges were tested: one unmodified as a control and one modified. To reduce EMI below safety limits, one centrifuge was modified to become a Faraday shield, in which significant electrical contact was made between all regions of the centrifuge housing. This included removing non-conductive paint, applying conductive fabric to the lid and foam sealer, adding a 10,000 F decoupling capacitor across the power supply, and adding copper adhesive-mount gaskets to the housing interior. EMI testing of both centrifuges was performed in the EMI/EMC Control Test and Measurement Facility. EMI for both centrifuges was below safety limits for frequencies between 10 MHz and 15 GHz (pass); however, between 14 kHz and 10 MHz, EMI for the unmodified centrifuge exceeded safety limits (fail) as expected. Alternatively, for the modified centrifuge with the Faraday shield, EMI was below the safely limit of 55 dBV/m for electromagnetic frequencies between 14 kHz and 10 MHz. This result indicates our modifications were successful. The successful EMI test allowed us to communicate with the vendor what modifications they needed to make to their commercial unit to meet our specifications and to understand what needs to be done in lab to the new centrifuge. Our modifications will provide a standard for readying centrifuges for future missions. Once the new modified centrifuge arrives by the vendor, it will need to undergo EMI testing again for validation. The centrifuge is also in the process of compatibility testing with a custom stowage drawer, which is an ongoing project in SF4. Both of these items will be payloads on future missions to the ISS for various research purposes. Ultrasound: ISS currently has an onboard ultrasound (Ultrasound 2 system) for research and medical purposes. Every piece of medical flight hardware has an equivalent ground-unit so instrumentation can be routinely evaluated and transported to the ISS if necessary. The ground-unit ultrasound equipment must be evaluated every six months using a task performance sheet (TPS). A TPS is a document, written by the appropriate scientists and engineers, which describes how to run equipment and is written in such a way that astronauts with unspecialized training can follow the tasks. I was responsible for performing six TPSs on a combination of three ultrasounds and two video power converters (VPCs). Performing a TPS involves checking out and computationally documenting each piece of equipment removed from storage locations, setting up hardware and software, performing tasks to verify functionality, returning equipment, and logging items back into the computerized system. My work revealed all ground-unit ultrasounds were functioning properly. Because of proper function, a discrepancy report (DR) did not have to be opened. The TPS was then passed along to the Quality Engineering (QE) for review and ultimately given to Quality Assurance (QA). Other projects: In addition to my main projects, I participated in other tasks including troubleshooting an EEG headband, volunteering for an ultrasound training research study, and conformal coating printed circuit boards. My internship at SF4 has helped me understand how space systems hardware development for the ISS fits into NASA's mission and vision.
    Keywords: Spacecraft Design, Testing and Performance
    Type: JSC-CN-36906
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  • 46
    Publication Date: 2019-07-12
    Description: Human space exploration to date has been confined to low-Earth orbit and the Moon. The International Space Station (ISS) provides a unique opportunity for researchers to prove out the technologies that will enable humans to safely live and work in space for longer periods of time and venture beyond the Earth/Moon system. The ability to manufacture parts in-space rather than launch them from Earth represents a fundamental shift in the current risk and logistics paradigm for human spaceflight. In September 2014, NASA, in partnership with Made In Space, Inc., launched the 3D Printing in Zero-G technology demonstration mission to explore the potential of additive manufacturing for in-space applications and demonstrate the capability to manufacture parts and tools on orbit using fused deposition modeling. This Technical Publication summarizes the results of testing to date of the ground control and flight prints from the first phase of this ISS payload.
    Keywords: Spacecraft Design, Testing and Performance
    Type: NASA/TP-2016-219101 , M-1415 , MSFC-E-DAA-TN31491
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  • 47
    Publication Date: 2019-07-12
    Description: A method and apparatus for docking a spacecraft. The apparatus comprises elongate members, movement systems, and force management systems. The elongate members are associated with a docking structure for a spacecraft. The movement systems are configured to move the elongate members axially such that the docking structure for the spacecraft moves. Each of the elongate members is configured to move independently. The force management systems connect the movement systems to the elongate members and are configured to limit a force applied by the each of the elongate members to a desired threshold during movement of the elongate members.
    Keywords: Spacecraft Design, Testing and Performance
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  • 48
    Publication Date: 2019-07-12
    Description: The present invention is directed to methods of manufacturing bioactive gels from ECM material, i.e., gels which retain bioactivity, and can serve as scaffolds for preclinical and clinical tissue engineering and regenerative medicine approaches to tissue reconstruction. The manufacturing methods take advantage of a new recognition that bioactive gels from ECM material can be created by digesting particularized ECM material in an alkaline environment and neutralizing to provide bioactive gels.
    Keywords: Life Sciences (General)
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  • 49
    Publication Date: 2019-07-12
    Description: A method and an apparatus for detecting and quantifying bacterial spores on a surface. In accordance with the method: bacterial spores are transferred from a place of origin to a test surface, the test surface comprises lanthanide ions. Aromatic molecules are released from the bacterial spores; a complex of the lanthanide ions and aromatic molecules is formed on the test surface, the complex is excited to generate a characteristic luminescence on the test surface; the luminescence on the test surface is detected and quantified.
    Keywords: Life Sciences (General)
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  • 50
    facet.materialart.
    Unknown
    In:  CASI
    Publication Date: 2019-07-12
    Description: Long duration space exploration will require the capability for crews to grow their own food. Growing food is desirable from a mass-efficiency standpoint, as it is currently not feasible to carry enough prepackaged food on spacecraft to sustain crews for long duration missions. Nutritionally, fresh produce provides key nutrients that are not preserved well in pre-packaged meals (e.g. vitamins C and K) and those that are able to counteract detrimental effects of space flight, such as antioxidants to combat radiation exposure and lutein for decreasing macular degeneration. Additionally, there are significant psychological benefits of maintaining gardens, one being an indicator for the passage of time.
    Keywords: Life Sciences (General)
    Type: KSC-E-DAA-TN33920
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  • 51
    facet.materialart.
    Unknown
    In:  CASI
    Publication Date: 2019-07-12
    Description: No abstract available
    Keywords: Spacecraft Design, Testing and Performance
    Type: JSC-CN-37462
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  • 52
    Publication Date: 2019-07-12
    Description: A sealing construct for a space environment includes a seal-bearing object, a seal on the seal-bearing object, and a seal-engaging object. The seal includes a seal body having a sealing surface, and a textured pattern at the sealing surface, the textured pattern defining at least one shaded channel surface. The seal-engaging object is selectively engaged with the seal-bearing object through the seal. The seal-engaging object has a sealing surface, wherein, when the seal-engaging object is selectively engaged with the seal-bearing object, the sealing surface of the seal-engaging object engages the sealing surface of the seal, and the seal is compressed between the seal-bearing object and the seal-engaging object such that at least one shaded channel surface engages the sealing surface of the seal-engaging object.
    Keywords: Spacecraft Design, Testing and Performance
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  • 53
    Publication Date: 2019-07-12
    Description: NASA Marshall Space Flight Center (MSFC) and the Agency as a whole are currently engaged in a number of in-space manufacturing (ISM) activities that have the potential to reduce launch costs, enhance crew safety, and provide the capabilities needed to undertake long-duration spaceflight. The recent 3D Printing in Zero-G experiment conducted on board the International Space Station (ISS) demonstrated that parts of acrylonitrile butadiene styrene (ABS) plastic can be manufactured in microgravity using fused deposition modeling (FDM). This project represents the beginning of the development of a capability that is critical to future NASA missions. Current and future ISM activities will require the development of baseline material properties to facilitate design, analysis, and certification of materials manufactured using in-space techniques. The purpose of this technical interchange meeting (TIM) was to bring together MSFC practitioners and experts in materials characterization and development of baseline material properties for emerging technologies to advise the ISM team as we progress toward the development of material design values, standards, and acceptance criteria for materials manufactured in space. The overall objective of the TIM was to leverage MSFC's shared experiences and collective knowledge in advanced manufacturing and materials development to construct a path forward for the establishment of baseline material properties, standards development, and certification activities related to ISM. Participants were asked to help identify research and development activities that will (1) accelerate acceptance and adoption of ISM techniques among the aerospace design community; (2) benefit future NASA programs, commercial technology developments, and national needs; and (3) provide opportunities and avenues for further collaboration.
    Keywords: Spacecraft Design, Testing and Performance
    Type: NASA/TM-2016-218219 , M16-4913
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  • 54
    Publication Date: 2019-07-19
    Description: Human space exploration to date has been limited to low Earth orbit and the moon. The International Space Station (ISS), an orbiting laboratory 200 miles above the earth, provides a unique and incredible opportunity for researchers to prove out the technologies that will enable humans to safely live and work in space for longer periods of time and venture farther into the solar system. The ability to manufacture parts in-space rather than launch them from earth represents a fundamental shift in the current risk and logistics paradigm for human spaceflight. In particularly, additive manufacturing (or 3D printing) techniques can potentially be deployed in the space environment to enhance crew safety (by providing an on-demand part replacement capability) and decrease launch mass by reducing the number of spare components that must be launched for missions where cargo resupply is not a near-term option. In September 2014, NASA launched the 3D Printing in Zero G technology demonstration mission to the ISS to explore the potential of additive manufacturing for in-space applications and demonstrate the capability to manufacture parts and tools on-orbit. The printer for this mission was designed and operated by the company Made In Space under a NASA SBIR (Small Business Innovation Research) phase III contract. The overarching objectives of the 3D print mission were to use ISS as a testbed to further maturation of enhancing technologies needed for long duration human exploration missions, introduce new materials and methods to fabricate structure in space, enable cost-effective manufacturing for structures and mechanisms made in low-unit production, and enable physical components to be manufactured in space on long duration missions if necessary. The 3D print unit for fused deposition modeling (FDM) of acrylonitrile butadiene styrene (ABS) was integrated into the ISS Microgravity Science Glovebox (MSG) in November 2014 and phase I printing operations took place from November through December of that year. Phase I flight operations yielded 14 unique parts (21 total specimens) that could be directly compared against ground-based prints of identical geometry manufactured using the printer prior to its launch to ISS. The 3DP unit functioned safely and produced specimens necessary to advance the understanding of the critical design and operational parameters for the FDM process as affected by the microgravity environment. From the standpoint of operations, 3DP demonstrated the ability to remove parts from the build-tray on-orbit, teleoperate the printer from the ground, perform critical maintenance functions within defined human factors limits, produce a functional tool that could be evaluated for form/fit/function, and uplink a new part file from the ground and produce it on the printer. The flight parts arrived at NASA Marshall Space Flight Center in Huntsville, Alabama in April 2015, where they underwent months of testing in the materials and processes laboratory. Ground and flight prints completed the following phases of testing: photographic/visual inspection, mass and density evaluation, structured light scanning, XRay and CT, mechanical testing, optical microscopy, scanning electron microscopy, and chemical analysis. This presentation will discuss the results of this testing as well as phase II operations for the printer, which took place in June and July of 2016. Lessons learned from the tech demo and their impacts on the design and development of the second generation 3D printer for ISS, the Additive Manufacturing Facility (AMF) by Made In Space will also be presented. In addition, progress in other elements of NASA's In Space Manufacturing (ISM) initiative such as the on-demand ISM utilization catalog, in-space Recycler ISS Technology Demonstration development, launch packaging recycling, in-space printable electronics, development of higher strength polymeric materials for 3D printing and Additive Construction by Mobile Emplacement (ACME) will also be addressed.
    Keywords: Spacecraft Design, Testing and Performance
    Type: M16-5487 , AIAA Young Professionals Symposium; Oct 20, 2016 - Oct 21, 2016; Huntsville, AL; United States
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  • 55
    Publication Date: 2019-07-19
    Description: International Space Station (ISS) assembly complete ushered a new era focused on utilization of this state-of-the-art orbiting laboratory to advance science and technology research in a wide array of disciplines, with benefits to Earth and space exploration. ISS enabling capability for research in cellular and molecular biology includes equipment for in situ, on-orbit analysis of biomolecules. Applications of this growing capability range from biomedicine and biotechnology to the emerging field of Omics. For example, Biomolecule Sequencer is a space-based miniature DNA sequencer that provides nucleotide sequence data for entire samples, which may be used for purposes such as microorganism identification and astrobiology. It complements the use of WetLab-2 SmartCycler"TradeMark", which extracts RNA and provides real-time quantitative gene expression data analysis from biospecimens sampled or cultured onboard the ISS, for downlink to ground investigators, with applications ranging from clinical tissue evaluation to multigenerational assessment of organismal alterations. And the Genes in Space-1 investigation, aimed at examining epigenetic changes, employs polymerase chain reaction to detect immune system alterations. In addition, an increasing assortment of tools to visualize the subcellular distribution of tagged macromolecules is becoming available onboard the ISS. For instance, the NASA LMM (Light Microscopy Module) is a flexible light microscopy imaging facility that enables imaging of physical and biological microscopic phenomena in microgravity. Another light microscopy system modified for use in space to image life sciences payloads is initially used by the Heart Cells investigation ("Effects of Microgravity on Stem Cell-Derived Cardiomyocytes for Human Cardiovascular Disease Modeling and Drug Discovery"). Also, the JAXA Microscope system can perform remotely controllable light, phase-contrast, and fluorescent observations. And upcoming confocal microscopy capability will allow for optical sectioning of biological tissues to determine microanatomical localization of biomarkers. Furthermore, NASA's geneLAB effort addresses integration of genomic, epigenomic, transcriptomic, proteomic and metabolomic datasets, by applying an innovative open source science platform for multi-investigator high throughput utilization of the ISS. In sum, the expanding ISS capability for analysis of biomolecules is enabling innovative research in a broad spectrum of areas such as cellular and molecular biology, biotechnology, tissue engineering, biomedicine, and Omics, providing manifold benefits for humanity.
    Keywords: Life Sciences (General)
    Type: JSC-CN-36567 , Annual Meeting of the American Society for Gravitational and Space Research; Oct 26, 2016 - Oct 29, 2016; Cleveland, OH; United States
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  • 56
    Publication Date: 2019-07-19
    Description: The NASA Decadal Survey (2011) emphasized the importance of long duration rodent experiments on the International Space Station (ISS). To accomplish this objective, flight hardware and science capabilities supporting mouse studies in space were developed at Ames Research Center. Here we present a video-based behavioral analysis of ten C57BL6 female adult mice exposed to a total of 37 days in space compared with identically housed Ground Controls. Flight and Control mice exhibited the same range of behaviors, including feeding, drinking, exploratory behavior, grooming, and social interactions. Mice propelled themselves freely and actively throughout the Habitat using their forelimbs to push off or by floating from one cage area to another. Overall activity was greater in Flt as compared to GC mice. Spontaneous, organized circling or race-tracking behavior emerged within the first few days of flight and encompassed the primary dark cycle activity for the remainder of the experiment. I will summarize qualitative observations and quantitative comparisons of mice in microgravity and 1g conditions. Behavioral phenotyping revealed important insights into the overall health and adaptation of mice to the space environment, and identified unique behaviors that can guide future habitat development and research on rodents in space.
    Keywords: Life Sciences (General)
    Type: ARC-E-DAA-TN32780 , Life in Space for Life on Earth 2016; Jun 05, 2016 - Jun 10, 2016; Toulouse; France
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  • 57
    Publication Date: 2019-07-19
    Description: After spaceflight, the number of immune cells is reduced in humans. In other research models, including Drosophila, not only is there a reduction in the number of plasmatocytes, but expression of immune-related genes is also changed after spaceflight. These observations suggest that the immune system is compromised after exposure to microgravity. It has also been reported that there is a change in virulence of some bacterial pathogens after spaceflight. We recently observed that samples of gram-negative S. marcescens retrieved from spaceflight is more virulent than ground controls, as determined by reduced survival and increased bacterial growth in the host. We were able to repeat this finding of increased virulence after exposure to simulated microgravity using the rotating wall vessel, a ground based analog to microgravity. With the ground and spaceflight samples, we looked at involvement of the Toll and Imd pathways in the Drosophila host in fighting infection by ground and spaceflight samples. We observed that Imd-pathway mutants were more susceptible to infection by the ground bacterial samples, which aligns with the known role of this pathway in fighting infections by gram-negative bacteria. When the Imd-pathway mutants were infected with the spaceflight sample, however, they exhibited the same susceptibility as seen with the ground control bacteria. Interestingly, all mutant flies show the same susceptibility to the spaceflight bacterial sample as do wild type flies. This suggests that neither humoral immunity pathway is effectively able to counter the increased pathogenicity of the space-flown S. marcescens bacteria.
    Keywords: Life Sciences (General)
    Type: ARC-E-DAA-TN36470 , Annual Meeting of the American Society for Gravitational and Space Research (ASGSR) 2016; Oct 26, 2016 - Oct 29, 2016; Cleveland, OH; United States
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  • 58
    Publication Date: 2019-07-19
    Description: Ionizing radiation-induced bone loss appears to be a two-stage process: first an early increase in pro-resorption cytokines and increased bone resorption by osteoclasts, followed by a decrease in bone formation by osteoblasts. This results in a net loss of mass in mineralized bone tissue. The molecular mechanisms underlying the imbalance in bone remodeling caused by exposure to radiation are not fully understood. We hypothesized that the radiation-induced rise in reactive oxygen species (ROS) damages osteoblast progenitors, leading to a decrease in number and activity of differentiated progeny. We have shown that a diet high in antioxidant capacity prevents radiation-induced bone loss in adult mice (Schreurs et al. 2016) by reducing the early increase in pro-resotption cytokines. Here, we investigated the damaging effects of radiation exposure on cells in the osteoblast lineage, testing if addition of the exogenous antioxidant enzyme, superoxide dismutase (SOD) can mitigate radiation damage. Osteoprogenitors were grown in vitro from the marrow of 16wk old, male C57Bl/6 mice. Cells were irradiated 3 days after plating (day 0) with either gamma (Cs-137, 0.1-5Gy) or iron (Fe-56, 600 MeV/n, 0.5-2Gy), and then grown until day 10. SOD or vehicle was added 2 hours before irradiation (SOD at 200U/ml), twice a day and up to day 5, for a total of 2 days treatment. Cell behavior was assessed by: (a) colony number (counted on day 7), (b) DNA content (surrogate for cell number) to assess cell growth (percent change between day 3 and day 10) and (c) alkaline phosphatase activity (osteoblast differentiation marker). Results show that SOD protected cells from the adverse effects of low-LET ionizing radiation, but not high-LET radiation. These novel results provide an interesting platform to explore further diverse effects and damages caused by low-LET and high-LET, pointing toward different mechanisms and possible intervention strategies for radiation-induced bone loss.
    Keywords: Life Sciences (General)
    Type: ARC-E-DAA-TN36265 , American Society for Cell Biology (ASCB) Meeting 2016; Dec 03, 2016 - Dec 07, 2016; San Francisco, CA; United States
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  • 59
    Publication Date: 2019-07-19
    Description: The NASA Decadal Survey (2011), Recapturing a Future for Space Exploration: Life and Physical Sciences Research for a New Era, emphasized the importance of expanding NASA life sciences research to long duration, rodent experiments on the International Space Station (ISS). To accomplish this objective, flight hardware, operations, and science capabilities supporting mouse studies in space were developed at NASA Ames Research Center. The first flight experiment carrying mice, Rodent Research Hardware and Operations Validation (Rodent Research-1), was launched on Sept 21, 2014 in an unmanned Dragon Capsule, SpaceX4, exposing the mice to a total of 37 days in space. Ground control groups were maintained in environmental chambers at Kennedy Space Center. Mouse health and behavior were monitored for the duration of the experiment via video streaming. Here we present behavioral analysis of two groups of five C57BL/6 female adult mice viewed via fixed camera views compared with identically housed Ground Controls. Flight (Flt) and Ground Control (GC) mice exhibited the same range of behaviors, including eating, drinking, exploratory behavior, self- and allo-grooming, and social interactions at similar or greater levels of occurrence. Mice propelled themselves freely and actively throughout the Habitat using their forelimbs to push off or by floating from one cage area to another, and they quickly learned to anchor themselves using tails and/or paws. Overall activity was greater in Flt as compared to GC mice, with spontaneous ambulatory behavior including the development of organized circling or race-tracking behavior that emerged within the first few days of flight and encompassed the primary dark cycle activity for the remainder of the experiment. We quantified the bout frequency, duration and rate of circling with respect to characteristic behaviors observed in the varying stages of the progressive development of circling: flipping utilizing two sides of the habitat, circling, multi-lap circling and group-circling. Once begun, mice did not regress to flipping behavior or other previous behavioral milestones for the remainder of flight. An overall upward trend in circling frequency, rate, duration, participation, and organization was observed over the course of the 37-day spaceflight experiment. In this presentation, we will summarize qualitative observations and quantitative comparisons of mice in microgravity and 1g conditions. Behavioral analyses provide important insights into the overall health and adaptation of mice to the space environment, and identify unique behaviors and social interactions to guide future habitat development and research on rodents in space.
    Keywords: Life Sciences (General)
    Type: ARC-E-DAA-TN28255 , 2016 Human Research Program Investigators Workshop; Feb 08, 2016 - Feb 11, 2016; Galveston, TX; United States
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  • 60
    Publication Date: 2019-07-19
    Description: Living organisms control their cellular biological clocks to maintain functional oscillation of the redox cycle, also called the "metabolic cycle" or "respiratory cycle". Organization of cellular processes requires parallel processing on a synchronized time-base. These clocks coordinate the timing of all biochemical processes in the cell, including energy production, DNA replication, and RNA transcription. When this universal time keeping function is perturbed by exogenous induction of reactive oxygen species (ROS), the rate of metabolism changes. This causes oxidative stress, aging and mutations. Therefore, good temporal coordination of the redox cycle not only actively prevents chemical conflict between the reductive and oxidative partial reactions; it also maintains genome integrity and lifespan. Moreover, this universal biochemical rhythm can be disrupted by ROS induction in vivo. This in turn can be achieved by blocking the electron transport chain either endogenously or exogenously by various metabolites, e.g. hydrogen sulfide (H2S), highly diffusible drugs, and carbon monoxide (CO). Alternatively, the electron transport in vivo can be attenuated via a coherent or interfering transfer of energy from exogenous ultralow frequency (ULF) and extremely low frequency (ELF) electromagnetic (EM) fields, suggesting that-on Earth-such ambient fields are an omnipresent (and probably crucially important) factor for the time-setting basis of universal biochemical reactions in living cells. Our work demonstrated previously un-described evidence for quantum effects in biology by electromagnetic coupling below thermal noise at the universal electron transport chain (ETC) in vivo.
    Keywords: Life Sciences (General)
    Type: ARC-E-DAA-TN28270 , 2016 Human Research Program Investigators'' Workshop (HRP IWS 2016); Feb 08, 2016 - Feb 11, 2016; Galveston, TX; United States
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  • 61
    Publication Date: 2019-07-19
    Description: Spacecraft charging induced by high voltage solar arrays can result in power losses and degradation of spacecraft surfaces. In some cases, it can even present safety issues for astronauts performing extravehicular activities. An understanding of the dominant processes contributing to spacecraft charging induced by solar arrays is important to current space missions, such as the International Space Station, and to any future space missions that may employ high voltage solar arrays. A common method of analyzing the factors contributing to spacecraft charging is the current balance model. Current balance models are based on the simple idea that the spacecraft will float to a potential such that the current collecting to the surfaces equals the current lost from the surfaces. However, when solar arrays are involved, these currents are dependent on so many factors that the equation becomes quite complicated. In order for a current balance model to be applied to solar array operations, it must incorporate the time dependent nature of the charging of dielectric surfaces in the vicinity of conductors1-3. This poster will present the factors which must be considered when developing a current balance model for high voltage solar array operations and will compare results of a current balance model with data from the Floating Potential Measurement Unit4 on board the International Space Station.
    Keywords: Spacecraft Design, Testing and Performance
    Type: M16-5557 , Annual Wernher von Braun Memorial Symposium; Oct 25, 2016 - Oct 27, 2016; Huntsville, AL; United States
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  • 62
    Publication Date: 2019-07-19
    Description: On December 5, 2014 NASA conducted the first flight test of its next generation human-class Orion spacecraft. The flight was called the Exploration Flight Test -1 (EFT-1) which lasted for 4 hours and culminated into a re-entry trajectory at 9 km/s. This flight test of the 5-meter Orion Crew Module demonstrated various sub-systems including the Avcoat ablative thermal protection system (TPS) on the heat shield. The Avcoat TPS had been developed from the Apollo-era recipe with a few key modifications. The engineering for thermal sizing was supported by modeling, analysis, and ground tests in arc jet facilities. This paper will describe a postlfight analysis plan and present results from post-recovery inspections, data analysis from embedded sensors, TPS sample extraction and characterization in the laboratory. After the recovery of the vehicle, a full photographic survey and surface scans of the TPS were performed. The recovered vehicle showed physical evidence of flow disturbances, varying degrees of surface roughness, and excessive recession downstream of compression pads. The TPS recession was measured at more than 200 locations of interest on the Avcoat surface. The heat shield was then processed for sample extraction prior to TPS removal using the 7-Axis Milling machine at Marshall Space Flight Center. Around 182 rectangular TPS samples were extracted for subsequent analysis and investigation. The final paper will also present results of sample analysis. The planned investigation includes sidewall imaging, followed by image analysis to characterize TPS response by quantifying different layers in the char and pyrolysis zones. A full postmortem of the instrumentation and sensor ports will also be performed to confirm no adverse effects due to the sensors themselves. A subset of the samples will undergo structural testing and perform detailed characterization of any cracks and integrity of gore seams. Finally, the material will be characterized with layer-by-layer density measurements and SEM investigations to evaluate material morphology at microstructural level including identification of elements and compounds.
    Keywords: Spacecraft Design, Testing and Performance
    Type: ARC-E-DAA-TN28016 , AIAA Thermophysics Conference; Jun 13, 2016 - Jun 17, 2016; Washington, DC; United States
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  • 63
    Publication Date: 2019-07-19
    Description: Over a decade of work has been conducted in the development of NASA's Hypersonic Inflatable Aerodynamic Decelerator (HIAD) deployable aeroshell technology. This effort has included multiple ground test campaigns and flight tests culminating in the HIAD project's second generation (Gen-2) aeroshell system. The HIAD project team has developed, fabricated, and tested stacked-torus inflatable structures (IS) with flexible thermal protection systems (F-TPS) ranging in diameters from 3-6 meters, with cone angles of 60 and 70 degrees. To meet NASA and commercial near-term objectives, the HIAD team must scale the current technology up to 12-15 meters in diameter. Therefore, the HIAD project's experience in scaling the technology has reached a critical juncture. Growing from a 6-meter to a 15-meter class system will introduce many new structural and logistical challenges to an already complicated manufacturing process. Although the general architecture and key aspects of the HIAD design scale well to larger vehicles, details of the technology will need to be reevaluated and possibly redesigned for use in a 15-meter-class HIAD system. These include: layout and size of the structural webbing that transfers load throughout the IS, inflatable gas barrier design, torus diameter and braid construction, internal pressure and inflation line routing, adhesives used for coating and bonding, and F-TPS gore design and seam fabrication. The logistics of fabricating and testing the IS and the F-TPS also become more challenging with increased scale. Compared to the 6-meter aeroshell (the largest HIAD built to date), a 12-meter aeroshell has four times the cross-sectional area, and a 15-meter one has over six times the area. This means that fabrication and test procedures will need to be reexamined to account for the sheer size and weight of the aeroshell components. This will affect a variety of steps in the manufacturing process, such as: stacking the tori during assembly, stitching the structural webbing, initial inflation of tori, and stitching of F-TPS gores. Additionally, new approaches and hardware will be required for handling and ground testing of both individual tori and the fully assembled HIADs. There are also noteworthy benefits of scaling up the HIAD aeroshell to a 15m-class system. Two complications in working with handmade textile structures are the non-linearity of the material components and the role of human accuracy during fabrication. Larger, more capable, HIAD structures should see much larger operational loads, potentially bringing the structural response of the material components out of the non-linear regime and into the preferred linear response range. Also, making the reasonable assumption that the magnitude of fabrication accuracy remains constant as the structures grow, the relative effect of fabrication errors should decrease as a percentage of the textile component size. Combined, these two effects improve the predictive capability and the uniformity of the structural response for a 12-15-meter HIAD. In this presentation, a handful of the challenges and associated mitigation plans will be discussed, as well as an update on current manufacturing and testing that addressing these challenges.
    Keywords: Spacecraft Design, Testing and Performance
    Type: ARC-E-DAA-TN30768 , International Planetary Probe Workshop (IPPW 2016); Jun 13, 2016 - Jun 17, 2016; Laurel, MD; United States
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  • 64
    Publication Date: 2019-07-19
    Description: Our overarching goal is to discover how the structure of the genotypic space of RNA polymers affects their ability to evolve. Specifically, we will address several fundamental questions that, so far, have remained largely unanswered. Was the genotypic space explored globally or only locally? Was the outcome of early evolution predictable or was it, instead, govern by chance? What was the role of neutral mutations in the evolution of increasing complex systems? As the first step, we study the problem in the example of RNA ligases. We obtain the complete, empirical fitness landscapes for short ligases and examine possible evolutionary paths for RNA molecules that are sufficiently long to preclude exhaustive search of the genotypic space.
    Keywords: Life Sciences (General)
    Type: ARC-E-DAA-TN36547 , NoR HGT & LUCA Conference; Nov 03, 2016 - Nov 04, 2016; Milton, Keynes; United Kingdom
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  • 65
    Publication Date: 2019-07-19
    Description: This presentation summarizes the Marshall Space Flight Center Natural Environments Terrestrial and Planetary Environments (TPE) Team support to the NASA Orion space vehicle. The TPE utilizes meteorological data to assess the sensitivities of the vehicle due to the terrestrial environment. The Orion vehicle, part of the Multi-Purpose Crew Vehicle Program, is designed to carry astronauts beyond low-earth orbit and is currently undergoing a series of tests including Exploration Test Flight (EFT) - 1. The presentation describes examples of TPE support for vehicle design and several tests, as well as support for EFT-1 and planning for upcoming Exploration Missions while emphasizing the importance of accounting for the natural environment's impact to the vehicle early in the vehicle's program.
    Keywords: Spacecraft Design, Testing and Performance
    Type: MI6-5054 , MY15-4385 , UAH''s Atmospheric Science Dept. Brown Bag Seminar; Feb 18, 2015; Huntsville, AL; United States
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  • 66
    Publication Date: 2019-07-20
    Description: The conditions encountered during spaceflight place unique stresses on physiological processes that oftentimes lead to deleterious effects. Identifying these effects and better understanding their molecular mechanisms will be essential in enabling long-duration space travel by humans. Studies in Saccharomyces cerevisiae suggest an aging model that involves the accumulation of toxic components, such as excess extrachromosomal rDNA and damaged mitochondria. This build-up then limits the replicative lifespan (the number of times a mother cell can form a new daughter cell). Remarkably, each new daughter cell emerges completely renewed from the senescing mother cell through an asymmetric distribution of aging determinants via mechanisms that are intricately linked to the budding process. When exposed to simulated microgravity, S. cerevisiae undergoes an altered budding process characterized by a breakdown in bud scar polarity. Because the budding process is critical to replicative aging, we hypothesize that the replicative lifespan may be affected by microgravity as well. To measure relative replicative aging rates, we will construct a strain of yeast in which daughter cells are inviable. In this strain, the Cre recombinase will be expressed under the control of the daughter cell specific promoter, pSCW11, and LoxP sites will be inserted at both flanks of two essential genes involved in the cell cycle, UBC9 and CDC20, using a CRISPRCas9 system. Thus, UBC9 and CDC20 will be excised from daughter cells, leading to cell-cycle arrest and eventual death. To mimic the low shear conditions encountered in microgravity, this strain will be grown in rotating wall vessels. The number of viable mother cells will be monitored over time, and this rate will be compared to cells growing in standard conditions. Because asymmetric division also occurs in mammalian cells (e.g. in neural stem cells), this study will provide insight into how cellular aging rates may change in mammals and will help empower humans to thrive in space for extended and even indefinite periods of time.
    Keywords: Life Sciences (General)
    Type: ARC-E-DAA-TN34927 , Yale UnderGrad Research Showcase; 9 Sept. 2016; New Haven, CT; United States
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  • 67
    Publication Date: 2019-07-20
    Description: No abstract available
    Keywords: Spacecraft Design, Testing and Performance
    Type: ARC-E-DAA-TN34580 , Annual AIAA/USU Conference on Small Satellites; Logan, UT; United States
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  • 68
    Publication Date: 2019-07-20
    Description: Cell and animal studies conducted onboard the International Space Station and formerly on Shuttle flights have provided groundbreaking data illuminating the deleterious biological response of bone to mechanical unloading. However the intercellular communicative mechanisms associated with the regulation of bone synthesis and bone resorption cells are still largely unknown. Connexin-43 (CX43), a gap junction protein, is hypothesized to play a significant role in osteoblast and osteocyte signaling. The purpose of this investigation was to evaluate within a novel three-dimensional microenvironment how the osteocyte-osteoblast gap-junction expression changes when cultures are exposed to exaggerated mechanical load. MLO-Y4 osteocyte-like cells were cultured on a 3D-Biotek polystyrene insert and placed in direct contact with an MC3T3-E1 pre-osteoblast co-cultured monolayer and exposed to 48 h of mechanical stimulation (pulsatile fluid flow (PFF) or monolayer cyclic stretch (MCS)) then evaluated for viability, proliferation, metabolism, and CX43 expression. Mono-cultured MLO-Y4 and MC3T3-E1 control experiments were conducted under PFF and MCS stimulation to observe how strain application stimuli (PFF cell membrane shear or MCS cell focal adhesionattachment loading) initiates different signaling pathways or downstream regulatory controls. TotalLive cell count, viability and metabolic reduction (Trypan Blue, LIVEDead and Alamar Blue analysis respectively) indicate that mechanical activation of MC3T3-E1 cells inhibits proliferation while maintaining an average 1.04E4 reductioncell metabolic rate, *p0.05 n4. MLO-Y4s in monolayer culture increase in number when exposed to MCS loading but the percent of live cells within the population is low (46.3 total count, *p0.05 n4), these results may indicate an apoptotic signaling cascade. PFF stimulation of the three-dimensional co-cultures elicits a universal increase in CX43 in MLO-Y4 and MC3T3-E1 cells, illustrated by immunohistological observation. Increased CX43 expression is also observed with the three-dimensional co-cultures with MC3T3-E1 MCS stimulation but the increased gap-junction protein presence was limited to the osteoblast-osteocyte interface region. Previously reported PCR evaluation of osteogenic markers further corroborate that the co-cultured populations communicative networks play a role in translating mechanical signals to molecular messaging. These findings suggests an osteocyte-osteoblast gap-junction signaling feedback mechanism may regulate mechanotransduction of apoptosis initiation and transcription of cytokine signaling proteins responsible for stem cell niche recruitment much more directly than previously believed.
    Keywords: Life Sciences (General)
    Type: ARC-E-DAA-TN36753 , Annual Meeting of the American Society for Gravitational and Space Research (ASGSR); Oct 26, 2016 - Oct 29, 2016; Cleveland, OH; United States
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  • 69
    Publication Date: 2019-07-20
    Description: Spaceflight has deleterious effects on skeletal structure and function, specifically causingprofound loss in bone mass, density, and strength, as well as changes in expression levels of genes related to oxidative stress [Hyeon et al., Smith et al.]. It is known that bone resorption remains elevated after spaceflight and that bone density and strength fail to recover completely even years following spaceflight [Smith et al., Carpenter et al.]. However, our current understanding of the signaling pathways and molecular mechanisms that control bone loss and that link oxidative stress, bone resorption, and mechanical unloading of skeletal tissue is incomplete. Here, we aim to examine skeletal responses to simulated long-duration spaceflight on bone loss using the ground-based hindlimb unloading (HU) model in adult (9 months old) male rats. We hypothesized that simulated microgravity leads to the temporal regulation of oxidative-defense genes and pro-osteoclastogenic factors, showing progression and eventual plateau during long-term unloading, and that transient changes at early timepoints in these pathways precede skeletal adaptations to long-duration unloading. We will identify oxidativestress and bone resorption-related changes using global gene expression analysis (Affymetrix arrays) for both acute (within 14 days) and long-term timepoints (90 days). We will also use quantitative PCR to examine changes in expression of genes related to oxidative metabolism (e.g. Nrf2, SOD-1), bone turnover (resorption and formation markers, e.g. TRAP, osteocalcin respectively, SOST), and osteoclastogenesis (e.g. RANKL, OPG) at both early and late timepoints. We will then use detailed microarchitectural and structural analysis through microcomputed tomography to relate gene expression changes with structural changes in bone, expecting that plateaus in gene expression correlate with long-term changes in bone microarchitecture.
    Keywords: Life Sciences (General)
    Type: ARC-E-DAA-TN33598 , Annual Meeting of the American Society for Gravitational and Space Research (ASGSR); Oct 26, 2016 - Oct 29, 2016; Cleveland, OH; United States
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  • 70
    Publication Date: 2019-07-20
    Description: Space radiation and micro-gravity are the two major obstacles impeding human exploration of Mars and beyond. Long-duration space flights expose astronauts to high doses of high linear energy transfer (LET) radiation as well as prolonged periods of skeletal disuse due to weightlessness. One important consequence of both radiation exposure and micro-gravity is acute bone loss. However, biological responses to different radiation types and combined radiation and micro-gravity environments remain unknown. Thus, the purpose of this study is to compare the acute effects of different radiation species and simulated weightlessness on bone degeneration for the purpose of developing accurate risk assessments of prolonged space flight. Mouse models were used to simulate space flight-relevant doses of different radiation types as well as weightlessness via hind-limb unloading. Three groups of mice (n 9) were irradiated with 1 Gy (Gray) H+, 1 Gy 56Fe, and 1 Gy combined H+ and 56Fe (dual ion) respectively and compared to sham irradiated (n 9) and 2 Gy 56Fe irradiated positive controls (n 6). Two groups of mice (n 9) were hind-limb unloaded for three days and then either sham irradiated or dual ion irradiated respectively, followed by subsequent hind-limb unloading for 11 days. Cancellous tissue from tibiae metaphyses were harvested 11 days post-irradiation for ex vivo micro-computed tomography analysis. Microarchitecture parameters including bone volume to total volume ratio (BVTV), trabecular thickness (Tb.Th), trabecular number (Tb.N), trabecular spacing (Tb.S), and connectivity density (Conn.D) will be quantified using a novel automated segmentation procedure developed in our lab. The anticipated results will be instrumental in developing counter-measures against micro-gravity and radiation-induced bone loss. Moreover, possible synergistic effects may provide insight into underlying mechanisms mediating biological response.
    Keywords: Life Sciences (General)
    Type: ARC-E-DAA-TN34526 , Annual Meeting of the American Society for Gravitational and Space Research (ASGSR 2016); Oct 26, 2016 - Oct 29, 2016; Cleveland, OH; United States
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  • 71
    Publication Date: 2019-07-23
    Description: In order to perform long term missions with multiple objectives using a single space vehicle, there is a need to develop a highly efficient propulsion-navigation system that enables multi-mission capabilities, point-to-point operation and an extended operational lifetime. The majority of space propulsion systems are fuel-based and require the vehicle to carry and consume fuel as part of the mission. Once the fuel is consumed, the mission is terminated. Alternatively, a method that derives its acceleration, velocity and direction from solar photon pressure using a solar sail to capture photon momentum would eliminate the requirement of fuel and all the fuel-based propulsion components. The most important factors that govern the solar sail spacecrafts characteristic acceleration are the sail loading (how much total mass the solar sail has to carry) and the exposed sail area. This paper introduces several potential mission concepts that can be achieved using heliogyro-configured solar sail spacecraft. It then presents 30 potential configurations of heliogyro small spacecraft solar sail and design concepts, based on CubeSat-scale units from 6U to 48U (1U = a cube 10 cm on each side). The area of the sail and total CubeSat masses are used to calculate their characteristic accelerations, and these accelerations are equated to those of previous spacecraft using solar sail technologies; IKAROS, NanoSail-D and LightSail. The analyses in this paper predict that out of these 30 configurations, the 12U-4B(a) configuration has the maximum and the 45U-6B(a) configuration has the minimum characteristic accelerations of 190 and 70 times higher than the IKAROS, 49 and 18 times higher than the NanoSail-D, and 16 and 6 times higher than LightSail, respectively. Several blade deployment configurations, the jelly roll, and a hybrid heliogyro-jelly roll are introduced and compared to the standard reel configuration. The hybrid configurations are predicted to produce higher characteristic accelerations than the jelly roll configurations. The analyses of heliogyro configurations suggest that the amount of payload units (non-sail) when compared to the whole spacecraft allowable units should be less than 40% and the optimized amount, i.e. no empty payload units, is approximately 33% to produce characteristic accelerations 〉 0.7 mm/sq s. For the hybrid configuration, the results suggests that the number of payload units should be between 30 40% of the total units to produce a characteristic acceleration 〉 0.8 mm/sq s.
    Keywords: Spacecraft Design, Testing and Performance
    Type: NF1676L-23565 , Acta Astronautica|International Astronautical Congress (IAC); Oct 12, 2015 - Oct 16, 2015; Jerusalem; Israel
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  • 72
    Publication Date: 2019-07-20
    Description: NASAs PowerCell payload on the DLR (Deutsches Zentrum fur Luft- und Raumfahrt, i.e. German Aerospace Center) Eu:CROPIS satellite will compare the effect of multiple simulated gravity regimes on basic processes required for synthetic biology in space including growth, protein production, and genetic transformation of the bacterium Bacillus subtilis. In addition, it will pioneer the use of a cyanobacterially-produced feedstock for microbial growth in space, a concept we call PowerCell. The PowerCell experiment system will be integrated using the Spaceflight Secondary Payload System with the German Space Agency's (DLR's) Euglena and Combined Regenerative Organic-food Production In Space (Eu:CROPIS) satellite, to be launched during the summer of 2017. In order to simulate the gravitational gradient of different celestial bodies, the Eu:CROPIS satellite will establish artificial microgravity, lunar, and Martian gravity levels prior to conducting each set of biological experiments, with experimental results compared to ground controls. Experiments will be carried out in microfluidics cards with experimental progress measured through absorbance as detected by the LED-based optical system. Here we describe the ground studies that led to these experiments, along with a description of the flight hardware and its performance. The results of this mission will provide foundational data for the use and production of genetically engineered organisms for extraterrestrial missions.
    Keywords: Life Sciences (General)
    Type: SSC-16-XI-04 , ARC-E-DAA-TN32950 , AIAA/USU Conference on Small Satellites; Aug 08, 2016 - Aug 13, 2016; Logan, UT; United States
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  • 73
    Publication Date: 2019-07-20
    Description: The Ames Life Science Data Archive (ALSDA) at NASA Ames Research Center is managed by the Space Biosciences Division and has been operational since 1993. The ALSDA is responsible for archiving information and biospecimens collected from life science spaceflight experiments and matching ground control experiments. They are stored in the Ames biobank, which is located in the Biospecimen Storage Facility (BSF). The ALSDA also manages a Biospecimen Sharing Program, performs curation and long-term storage operations, and makes biospecimens available to the scientific community for research purposes via the Life Science Data Archive public website (https:lsda.jsc.nasa.gov). The BSF maintains both fixed and frozen spaceflight and ground tissues, collected from recent and past spaceflight missions. Due to the ever increasing demand for space to preserve current and future flight biospecimens, the ALSDA has initiated the development of a culling plan for biospecimens currently stored in the BSF. Culling enables the ALSDA to assess the quality of archived samples, and supports the development of standardized culling procedures that improve the operational efficiency of the BSF. The culling plan focuses on generating disposition recommendations for samples in the BSF, and currently is based on measuring ribonucleic acid (RNA) integrity number (RIN). The culling process includes (1) sorting and identification of candidate samples for RIN analysis, (2) completion of RIN analysis on select samples, and (3) development of disposition recommendations for specimens based on the RIN values. Furthermore, our approach allows for unique scientific opportunities, including development of a RIN-based methodology for culling, and temporal assessment of the quality of the tissues that have been stored in BSF since the 1980s. Results of this work will also support NASA open science initiatives.
    Keywords: Life Sciences (General)
    Type: ARC-E-DAA-TN37076 , International Society for Biological and Environmental Repositories (ISBER) Regional Meeting; Nov 07, 2016 - Nov 08, 2016; Bethesda, MD; United States
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  • 74
    Publication Date: 2019-07-19
    Description: Altered gravity conditions, such as experienced by organisms during spaceflight, is known to cause transcriptomic and proteomic changes. We describe the proteomic changes in the whole body of adult Drosophila melanogaster (fruit fly), but focus specifically on the localized changes in the adult head in response to chronic hypergravity (3G) treatment. Canton S adult female flies (2-3 days old) were exposed to chronic hypergravity for 9 days and compared with parallel 1G controls. After hypergravity treatment, whole flies and fly heads were separated, and evaluated for quantitative comparison of the two gravity conditions using an isobaric tagging liquid chromatography-tandem mass spectrometry approach. Data revealed a total of 1948 (whole flies) and 1480 (head) proteins to be differentially present in hypergravity-treated flies. Gene Ontology analysis of head specific proteomics revealed host immune response and humoral stress proteins were significantly upregulated. Proteins related to calcium signaling, ion transport and ATPase were decreased. Enhanced expression of cuticular proteins may suggest an alteration in chitin metabolism and in chitin-based cuticle development. We therefore present a comprehensive quantitative survey of proteomic changes in response to chronic hypergravity in Drosophila, which will help elucidate the underlying molecular mechanisms associated with altered gravity environments.
    Keywords: Life Sciences (General)
    Type: ARC-E-DAA-TN31697
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  • 75
    Publication Date: 2019-07-26
    Description: This work describes the direct simulation Monte Carlo (DSMC) investigation of Saturn entry probe scenarios and the influence of non-equilibrium phenomena on Saturn entry conditions. The DSMC simulations coincide with rarefied hypersonic shock tube experiments of a hydrogen-helium mixture performed in the Electric Arc Shock Tube (EAST) at NASA Ames Research Center. To directly compare to the experimental results, the DSMC simulations are post-processed through the NEQAIR line-by-line radiation code. Improved collision cross-sections, inelastic collision parameters, and reaction rates are determined for a high temperature DSMC simulation of a 7-species H2-He mixture and an electronic excitation model is implemented in the DSMC code. Simulation results for 27.8 and 27.4 kms shock waves are obtained at 0.2 and 0.1 Torr respectively and compared to measured spectra in the VUV, UV, visible, and IR ranges. These results confirm the persistence of non-equilibrium for several centimeters behind the shock and the diffusion of atomic hydrogen upstream of the shock wave. Although the magnitude of the radiance did not match experiments and an ionization inductance period was not observed in the simulations, the discrepancies indicated where improvements are needed in the DSMC and NEQAIR models.
    Keywords: Spacecraft Design, Testing and Performance
    Type: ARC-E-DAA-TN32122 , AIAA Aviation Forum; Jun 13, 2016 - Jun 17, 2016; Washington, DC; United States
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  • 76
    Publication Date: 2019-07-20
    Description: Evidence from spaceflight and ground-based missions demonstrate that sleep loss and circadian desynchronization occur among astronauts, leading to reduced performance and, increased risk of injuries and accidents. We conducted a comprehensive literature review to determine the optimal sleep environment for lighting, temperature, airflow, humidity, comfort, intermittent and erratic sounds, privacy and security in the sleep environment. We reviewed the design and use of sleep environments in a wide range of cohorts including among aquanauts, expeditioners, pilots, military personnel, and ship operators. We also reviewed the specifications and sleep quality data arising from every NASA spaceflight mission, beginning with Gemini. We found that the optimal sleep environment is cool, dark, quiet, and is perceived as safe and private. There are wide individual differences in the preferred sleep environment; therefore modifiable sleeping compartments are necessary to ensure all crewmembers are able to select personalized configurations for optimal sleep.
    Keywords: Life Sciences (General)
    Type: ARC-E-DAA-TN56624 , International Conference on Applied Human Factors; Jul 27, 2016 - Jul 31, 2016; Orlando, FL; United States
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  • 77
    Publication Date: 2019-07-20
    Description: Human immune response is compromised and bacteria can become more antibiotic resistant in space microgravity (MG). We report that under low-shear modeled microgravity (LSMMG) stationary-phase uropathogenic Escherichia coli (UPEC) become more resistant to gentamicin (Gm). UPEC causes urinary tract infections (UTIs), reported to afflict astronauts; Gm is a standard treatment, so these findings could impact astronaut health. Because LSMMG has been shown to differ from MG, we report here preparations to examine UPEC's Gm sensitivity during spaceflight using the E. coli Anti-Microbial Satellite (EcAMSat) on a free flying nanosatellite in low Earth orbit. Within EcAMSats payload, a 48-microwell fluidic card contains and supports study of bacterial cultures at constant temperature; optical absorbance changes in cell suspensions are made at three wavelengths for each microwell and a fluid-delivery system provides growth medium and predefined Gm concentrations. Performance characterization is reported for spaceflight prototypes of this payload system. Using conventional microtiter plates, we show that Alamar Blue (AB) absorbance changes due to cellular metabolism accurately reflect E. coli viability changes: measuring AB absorbance onboard EcAMSat will enable telemetry of spaceflight data to Earth. Laboratory results using payload prototypes are consistent with wellplate and flask findings of differential sensitivity of UPEC and its delta rpoS strain to Gm. Space MG studies using EcAMSat should clarify inconsistencies from previous space experiments on bacterial antibiotic sensitivity. Further, if sigma (sup s) plays the same role in space MG as in LSMMG and Earth gravity, EcAMSat results would facilitate utilizing our previously developed terrestrial UTI countermeasures in astronauts.
    Keywords: Life Sciences (General)
    Type: ARC-E-DAA-TN35487
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  • 78
    Publication Date: 2019-07-13
    Description: In its twelfth year touring Saturn, the Cassini spacecraft continues to gather valuable scientific data about the planet and its moons. Cassini has executed a total of 331 propulsive maneuvers through January 23, 2016. With more than 30 maneuvers planned through July 2017 before the mission ends in September 2017, a dwindling propellant supply has become a chief concern. This manuscript will report on the analysis of Cassini maneuvers performed through December 30, 2015 and recommend execution-error models for the remainder of the mission. Maneuver performance assessment techniques and execution-error model development methods will also be outlined.
    Keywords: Spacecraft Design, Testing and Performance
    Type: AAS 16-305 , JPL-CL-16-0539 , AAS/AIAA Space Flight Mechanics Meeting; Feb 14, 2016 - Feb 18, 2016; Napa, CA; United States
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  • 79
    Publication Date: 2019-07-13
    Description: JPL has traditionally performed system level vibration testing of flight spacecraft. The benefits and potential issues of fully assembled flight spacecraft vibration testing are discussed herein. The following specific topics, which may be complementary to the special session on Virtual Vibration Testing, are discussed: spacecraft workmanship, functional and structural integrity testing to uncover workmanship problems, force- and moment-limited vibration testing, potential issues with structural frequency identification using base shake test data, and several failures related to vibration shaker testing. The information provided in this paper is complementary to the special session on Virtual Shaker Testing, and attention is given to issues that virtual shaker testing may face.
    Keywords: Spacecraft Design, Testing and Performance
    Type: JPL-CL-16-4234 , European Conference on Spacecraft Structures, Materials and Environmental Testing; Sep 27, 2016 - Sep 30, 2016; Toulouse; France
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  • 80
    Publication Date: 2019-07-13
    Description: Proposed is a scalable, six-degree-of-freedom, pressurized docking adapter that can connect multiple volumes while resolving all forces within itself. In a large space outpost pass-through connection is needed between multiple volumes to maintain a continuous pressurized cabin for crew access, translation, and egress. Zero-g docking and berthing of elements can be done using robotic arms, thrusters, and simple docking interface hardware because orthogonal mating is only governed by position, orientation, and momentum, but soft capture / hard docking techniques would not work in a gravity environment because modules cannot be brought in square with each other. Gravity docking is problematic in that any two elements have a gravity vector and it is not practical to provide a perfectly flat surface for them to rest on. Any stretch of natural or graded terrain still has surface fluctuations - maneuvering one element in respect to another would constantly be working against a gravity vector, where uneven surfaces would cause modules to come to rest in odd configurations in respect to each other. Manipulation of heavy elements, such as habitats will be difficult to do with precision -- elements may be placed as close as the mobility system can handle but would still leave the elements not in square with each other. The proposed Pressurized Adapter for "Shirt-Sleeve" Transfer and Universal Base Expansion (PASSTUBE) element will connect non-square and skewed elements while resolving all forces internal to itself.
    Keywords: Spacecraft Design, Testing and Performance
    Type: JPL-CL-16-3666 , AIAA/AAS Astrodynamics Specialist Conference; Sep 12, 2016 - Sep 15, 2016; Long Beach, CA; United States
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  • 81
    Publication Date: 2019-07-13
    Description: This paper describes the electromagnetic compatibility (EMC) requirements on the NASA SMAP mission, the implementation of EMC best practices at various levels of development in subsystems packaging and system level cabling harnesses, and the testing and result s of flight hardware at the sub system and spacecraft system levels.
    Keywords: Spacecraft Design, Testing and Performance
    Type: JPL-CL-16-1226 , 2016 IEEE International Symposium on Electromagnetic Compatibility; Jul 25, 2016 - Jul 29, 2016; Ottawa; Canada
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  • 82
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    Publication Date: 2019-07-13
    Description: In order to maximize the amount of omics data returned from space flight experiments, the GeneLab project can collaborate with Space Biology funded PIs. Here, we outline the process by which these collaborations take place.
    Keywords: Life Sciences (General)
    Type: ARC-E-DAA-TN36421 , Annual American Society for Gravitational and Space Research (ASGSR); Oct 25, 2016 - Oct 28, 2016; Cleveland, OH; United States
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  • 83
    Publication Date: 2019-07-13
    Description: APEX is Advanced Plant Experiments on Orbit which is a series of investigations which focus on fundamental plant biology.
    Keywords: Life Sciences (General)
    Type: KSC-E-DAA-TN33927 , MSFC Payload Operations Integration Working Group (POIWG) Meeting; Jan 26, 2016 - Jan 28, 2016; Huntsville, AL; United States
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  • 84
    Publication Date: 2019-07-13
    Description: No abstract available
    Keywords: Spacecraft Design, Testing and Performance
    Type: JSC-CN-35651-1 , Meeting of the Inter-Agency Debris Coordination Committee; Mar 29, 2016 - Apr 01, 2016; Didcot; United Kingdom
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  • 85
    Publication Date: 2019-07-13
    Description: Numerous mission support hardware systems and their spares are maintained outside of the habitable volume of the International Space Station (ISS), and are arranged covered by a multi-layer insulation (MLI) thermal blanket which provides both thermal control and a measure of protection from micrometeoroids and orbital debris (MMOD). The NASA Hypervelocity Impact Technology (HVIT) group at the Johnson Space Center in Houston Texas has assessed the protection provided by MLI in a series of hypervelocity impact tests using a 1 mm thick aluminum 6061-T6 rear wall to simulate the actual hardware behind the MLI. HVIT has also evaluated methods to enhance the protection provided by MLI thermal blankets. The impact study used both aluminum and steel spherical projectiles accelerated to speeds of 7 km/s using a 4.3 mm, two-stage, light-gas gun at the NASA White Sands Test Facility (WSTF).
    Keywords: Spacecraft Design, Testing and Performance
    Type: JSC-CN-35651-3 , Meeting of the Inter-Agency Debris Coordination Committee; Mar 29, 2016 - Apr 01, 2016; Didcot; United Kingdom
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  • 86
    Publication Date: 2019-07-13
    Description: No abstract available
    Keywords: Spacecraft Design, Testing and Performance
    Type: AIAA SciTech Conference; Jan 04, 2016 - Jan 08, 2016; San Diego, CA; United States
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  • 87
    Publication Date: 2019-07-13
    Description: Human-scale landers require the delivery of much heavier payloads to the surface of Mars than is possible with entry, descent, and landing (EDL) approaches used to date. A conceptual design was developed for a 10 m diameter crewed Mars lander with an entry mass of approx. 75 t that could deliver approx. 28 t of useful landed mass (ULM) to a zero Mars areoid, or lower, elevation. The EDL design centers upon use of a high ballistic coefficient blunt-body entry vehicle and throttled supersonic retro-propulsion (SRP). The design concept includes a 26 t Mars Ascent Vehicle (MAV) that could support a crew of 2 for approx. 24 days, a crew of 3 for approx.16 days, or a crew of 4 for approx.12 days. The MAV concept is for a fully-fueled single-stage vehicle that utilizes a single pump-fed 250 kN engine using Mono-Methyl Hydrazine (MMH) and Mixed Oxides of Nitrogen (MON-25) propellants that would deliver the crew to a low Mars orbit (LMO) at the end of the surface mission. The MAV concept could potentially provide abort-to-orbit capability during much of the EDL profile in response to fault conditions and could accommodate return to orbit for cases where the MAV had no access to other Mars surface infrastructure. The design concept for the descent stage utilizes six 250 kN MMH/MON-25 engines that would have very high commonality with the MAV engine. Analysis indicates that the MAV would require approx. 20 t of propellant (including residuals) and the descent stage would require approx. 21 t of propellant. The addition of a 12 m diameter supersonic inflatable aerodynamic decelerator (SIAD), based on a proven flight design, was studied as an optional method to improve the ULM fraction, reducing the required descent propellant by approx.4 t.
    Keywords: Spacecraft Design, Testing and Performance
    Type: AIAA SciTech 2016; Jan 04, 2016 - Jan 06, 2016; San Diego, CA; United States
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  • 88
    Publication Date: 2019-07-13
    Description: NASA's Cassini Spacecraft, launched on October 15th, 1997 which arrived at Saturn on June 30th, 2004, is the largest and most ambitious interplanetary spacecraft in history. As the first spacecraft to achieve orbit at Saturn, Cassini has collected science data throughout its four-year prime mission (200408), and has since been approved for a first and second extended mission through 2017. As part of the final extended missions, Cassini will begin an aggressive and exciting campaign of high inclination, low altitude flybys within the inner most rings of Saturn, skimming Saturns outer atmosphere, until the spacecraft is finally disposed of via planned impact with the planet. This final campaign, known as the proximal orbits, requires a strategy for managing the Sun Sensor Assembly (SSA) health, the details of which are presented in this paper.
    Keywords: Spacecraft Design, Testing and Performance
    Type: AIAA SciTech 2016; Jan 04, 2016 - Jan 06, 2016; San Diego, CA; United States
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  • 89
    Publication Date: 2019-07-13
    Description: Model-Based Systems Engineering (MBSE) can augment existing Systems Engineering (SE) processes to more efficiently deliver enhanced products over the project life cycle. Using a multi-user accessible System Model, MBSE has been successfully deployed for the conceptual and preliminary design development of the Asteroid Redirect Robotic Mission (ARRM). The paper provides an overview and examples of the targeted MBSE deployment for development of the mission operational concept, system description, and functional requirements. The paper also includes description of the challenges and lessons learned.
    Keywords: Spacecraft Design, Testing and Performance
    Type: JPL-CL-16-3986 , AIAA/AAS Astrodynamics Specialist Conference; Sep 12, 2016 - Sep 15, 2016; Long Beach, CA; United States
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  • 90
    Publication Date: 2019-07-13
    Description: The paper will describe the key technical drivers on the Sylph mission concept to explore a plume at Europa as a secondary free-flyer as a part of the planned Europa Mission. Sylph is a radiation-hardened smallsat concept that would utilize terrain relative navigation to fly at low altitudes through a plume, if found, and relay the mass spectra data back through the flyby spacecraft during its 24-hour mission. The second topic to be discussed will be the mission design constraints of the Near Earth Asterioid (NEA) Scout concept. NEAScout is a 6U cubesat that would utilize an 86 sq. m solar sail as propulsion to execute a flyby with a near-Earth asteroid and help retire Strategic Knowledge Gaps for future human exploration. NEAScout would cruise for 24 months to reach and characterize one Near-Earth asteroid that is representative of Human Exploration targets and telemeter that data directly back to Earth at the end of its roughly 2.5 year mission.
    Keywords: Spacecraft Design, Testing and Performance
    Type: JPL-CL-16-3936 , 67th International Astronautical Congress (IAC); Sep 26, 2016 - Sep 30, 2016; Guadalajara; Mexico
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  • 91
    Publication Date: 2019-07-13
    Description: Are NASAs space flight instruments becoming cheaper or more expensive as time marches forward? After analyzing the costs of hundreds of instruments launched over the last 30 years, the short answer to this question is no and yes. This paper gives a visual analysis of the cost time trends for various NASA space flight instrument types, such as optical, particles detectors, fields detectors and microwave instruments. In addition to the statistical approaches utilized, such as significance tests, cluster analysis and principle components analysis (PCA), we will also discuss the intangibles which are likely at play, including technological progress, NASA policy and the luck of the draw associated with mission manifests. This analysis was performed as the main driver for the NASA Instrument Cost Model (NICM) recent cost estimating model redesign. Started in 2004, the first version of NICM was based off of instruments launched from 1985-2005, or 20 years worth of data. As NICM hit its 10-year anniversary, we wanted to know: should NICM continue to only use the most recent 20 years worth of data (1995-2015)? Are instruments becoming cheaper or more expensive as time marches forward? There is evidence in favor of a drop in the median dollar-per-kg value across some instrument types, but little in others. Whereas further research is needed to substantiate, Particles and Optical-Planetary instrument types show moderate to strong evidence of a downward trend in dollar-per-kg. Further research is required to study the nature of this trend (shift, taper, cyclic, etc.). Little evidence for a similar downward trend was detected for Fields or Microwave instruments, or Optical instruments on Earth Orbiting spacecraft. We presented evidence in favor of a drop in the median dollar-per-kg value for Particles and Optical-Planetary instrument types. While similar evidence was weak at best for Fields and Microwave instruments. We can speculate as to the causes for this effect, but we are also equipped to begin to rule out, or at least prioritize, some of the suspected drivers. We observed, for Particles and Optical-Planetary instruments, that perhaps a launch manifest effect was playing part of the role in the observed decrease in dollar-per-kg over the years, noting that the more flagship class missions, which have more money to spend on their instruments, were seen in the earlier years in our data, versus the later years which were dominated by less expensive class missions. However, if this were a dominating driver, would we not have seen the downward trend in the Fields and Microwave instruments as well, which were drawn from that same launch manifest? The fact that we did not observe this helps us rule out the launch manifest effect, and other drivers, such as advances in technology, that seem to be more likely suspects. In that case, however, why would technology advances be helping the Particles and Optical-Planetary instruments only? Why would it not be impacting Optical-Earth Orbiting instruments? Further suspects were looked at as well and ruled out, such as the Faster, Better, Cheaperera of NASA development which did not seem to actually impact trends by instrument type on a dollar-perkg scale. VI. Future Work A. Time Series Detailed Statistical Assessment The analysis discussed above sets the foundation for a more rigorous time series analysis of the data. Time series analysis will further explore evidence to-date of time trends for the instrument types which showed the strongest indicators for a decrease in dollar-per-kg: Optical (Planetary) and Particles instruments. More than providing evidence and top-level significance tests, time series analysis would help elucidate what kind of trend that exists in the data, their significance and allow statistically based forecasting (see Figure 10)
    Keywords: Spacecraft Design, Testing and Performance
    Type: JPL-CL-16-3895 , AIAA/AAS Astrodynamics Specialist Conference; Sep 12, 2016 - Sep 15, 2016; Long Beach, CA; United States
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  • 92
    Publication Date: 2019-07-13
    Description: The Dawn mission, part of NASAs Discovery Program, has as its goal the scientific exploration of the two most massive main-belt objects, Vesta and Ceres. The Dawn spacecraft was launched from the Cape Canaveral Air Force Station on September 27, 2007 on a Delta-II 7925H- 9.5 (Delta-II Heavy) rocket that placed the 1218-kg spacecraft onto an Earth-escape trajectory. On-board the spacecraft is an ion propulsion system (IPS) developed at the Jet Propulsion Laboratory for the heliocentric transfer to Vesta, orbit capture at Vesta, transfer between Vesta science orbits, departure and escape from Vesta, heliocentric transfer to Ceres, orbit capture at Ceres, transfer between Ceres science orbits, and orbit maintenance maneuvers. Full-power thrusting from December 2007 through October 2008 was used to successfully target a Mars gravity assist flyby in February 2009 that provided an additional V of 2.6 km/s. Deterministic thrusting for the heliocentric transfer to Vesta resumed in June 2009 and concluded with orbit capture at Vesta on July 16, 2011. From July 2011 through September 2012 the IPS was used to transfer to all the different science orbits at Vesta and to escape from Vesta orbit. Cruise for a rendezvous with Ceres began in August 2012 and completed in late December 2014. From December 2014 through June 2016 the IPS was used for transiting the spacecraft to the Approach phase, survey orbit, the high altitude mapping orbit (HAMO), and the low altitude mapping orbit )LAMO) with arrival to LAMO on December 13, 2015, almost eight years after the start of deterministic thrusting to Vesta. The LAMO orbit, at a mean altitude above Ceres of approximately 385 km, is the spacecrafts final destination and there are no plans to move the spacecraft from LAMO once science operations there are completed. Since arrival at LAMO Dawns IPS has been used for occasional orbit maintenance maneuvers while the spacecraft performs scientific investigations. Dawn has successfully completed its science goals and Dawns primary mission is scheduled to end in the summer of 2016. To date the IPS has been operated for over 48,454 hours, consumed approximately 401 kg of xenon, and provided a delta-V of over 11.0 km/s, a record for an on-board propulsion system. The IPS performance characteristics are close to the expected performance based on analysis and testing performed pre-launch. Dawns IPS continues to be fully operational as of June 2016. This paper provides an overview of Dawns mission objectives and the results of Dawn IPS mission operations from Survey orbit through June 2016.
    Keywords: Spacecraft Design, Testing and Performance
    Type: JPL-CL-16-2620 , AIAA/SAE/ASEE Joint Propulsion Conference; Jul 25, 2016 - Jul 27, 2016; Salt Lake City, UT; United States
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  • 93
    Publication Date: 2019-07-13
    Description: NASAs Mars Science Laboratory (MSL) spacecraft successfully performed its Entry, Descent & Landing (EDL) phase on August 6, 2012. This paper presents the thermal response of the MSL spacecraft from EDL Initialization (5 days prior to Entry) to Rover touchdown on the surface of Mars. Temperature telemetry recorded during EDL is used to reconstruct the thermal response of the spacecraft to each EDL event. Temperature profiles for the Descent Stage and Rover hardware are presented and explained in the context of the changing EDL environments (aerothermal heating and convective cooling) and power states.
    Keywords: Spacecraft Design, Testing and Performance
    Type: JPL-CL-16-1805 , International Conference on Environmental Systems; Jul 10, 2016 - Jul 14, 2016; Vienna; Austria
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  • 94
    Publication Date: 2019-07-13
    Description: Although NASA has no official plans at this time for a mission to return samples from Mars, the Program Formulation Office of the Mars Exploration Program sponsors ongoing mission concept studies, systems analyses, and technology investments which explore different strategies for the potential return of samples from Mars, consistent with the charter of the program and stated priorities of the science community. Maintaining the thermal integrity of collected samples would be very important. In general, samples would be collected, sealed inside tubes, and left on the surface for later retrieval. They would then be inserted into an OS (Orbiting Sample), and carried to a Mars or Solar orbit via a MAV (Mars Ascent Vehicle). Subsequently, an Earth return vehicle would rendezvous with the OS and bring it back to Earth. During ascent from Mars, the OS could serve as the nose cone of the MAV and would be subjected to significant aerodynamic heating from the Martian atmosphere. Once the OS is released from the MAV, its external surface would be exposed to potentially several years of sunlight, eclipse, planetary IR, albedo, and space. The challenge is to ensure that these samples are kept at thermally moderate conditions to preserve their integrity in these widely different environments. Various thermal techniques have been investigated to achieve sample thermal control: use of thermal protection shields and surfaces (ablative and non-ablative) to protect them from adverse exposure to ascent heating, as well combinations of thermo-optical coatings during the orbital phase. The work described herein is part of this ongoing effort & will describe the key challenges related to the thermal control of the potential Mars samples during these phases and the corresponding schemes to overcome them.
    Keywords: Spacecraft Design, Testing and Performance
    Type: JPL-CL-16-1754 , International Conference on Environmental Systems; Jul 10, 2016 - Jul 14, 2016; Vienna; Austria
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  • 95
    Publication Date: 2019-07-13
    Description: In spacecraft that have propulsion lines that are located externally with open bus architecture, the lines are typically insulated by Multi Layer Insulation (MLI) blankets to protect them thermally from the cold space environment. In addition to heat loss through the insulation, mechanical supports used to attach the lines to the spacecraft structure also create heat leaks from the lines. These lines typically have very low thermal conduction in the axial direction, so the heat balance in the lines tends to be very local without much heat spreading. The typical allowable temperature range for hydrazine-based lines is +15/+50C. This tight temperature range has to be maintained for every location on these lines. For typical spacecraft, these lines can be several meters long. Temperature control is typically achieved by closed loop monitoring of temperatures along the lines and the corresponding powering of the heaters in a bang-bang approach to maintain the temperatures within the dead band of the control loop. The temperatures of propulsion lines are a function of several parameters with heat loss characteristics of the MLI being the key one. Unfortunately, this same key characteristic (MLI effective emittance) has a large variation along its length due to its dependence on workmanship, which in turn leads to large uncertainties in the propulsion lines local temperatures. Because of the poor conduction along the axial direction, heat balance along the length varies dramatically from one location to the next, even few inches apart, depending on the combination of the controlling parameters. This paper describes various robust design and implementation approaches that have been investigated to greatly reduce the randomness associated with predicting the temperature of these propulsion lines.
    Keywords: Spacecraft Design, Testing and Performance
    Type: JPL-CL-16-1741 , International Conference on Environmental Systems; Jul 10, 2016 - Jul 14, 2016; Vienna; Austria
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  • 96
    Publication Date: 2019-07-13
    Description: In its twelfth year touring Saturn, the Cassini spacecraft continues to gather valuable scientific data about the planet and its moons. Cassini has executed a total of 331 propulsive maneuvers through January 23, 2016. With more than 30 maneuvers planned through July 2017 before the mission ends in September 2017, a dwindling propellant supply has become a chief concern. This manuscript will report on the analysis of Cassini maneuvers performed through December 30, 2015 and recommend execution-error models for the remainder of the mission. Maneuver performance assessment techniques and execution-error model development methods will also be outlined.
    Keywords: Spacecraft Design, Testing and Performance
    Type: AAS 16-305 , JPL-CL-16-0424 , AAS/AIAA Space Flight Mechanics Meeting; Feb 14, 2016 - Feb 18, 2016; Napa, CA; United States
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  • 97
    Publication Date: 2019-07-13
    Description: NASAs Low-Density Supersonic Decelerator Project is developing and testing the next generation of supersonic aerodynamic decelerators for planetary entry. A key element of that development is the testing of full-scale articles in conditions relevant to their intended use, primarily in the tenuous Mars atmosphere. To achieve this testing, the LDSD project developed a new test architecture for the qualification of their supersonic parachute. A large, helium filled scientific balloon is used to hoist a 4.7 m blunt body test vehicle to an altitude of approximately 32 kilometers. The test vehicle is released from the balloon, spun up for gyroscopic stability, and accelerated to over four times the speed of sound and an altitude of 50 kilometers using a large solid rocket motor. Once at those conditions, the vehicle is despun and the test period begins.
    Keywords: Spacecraft Design, Testing and Performance
    Type: JPL-CL-16-0098 , IEEE Aerospace Conference; Mar 05, 2016 - Mar 12, 2016; Big Sky, MT; United States
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  • 98
    Publication Date: 2019-07-13
    Description: Bacterial growth at low pressure is a new research area with implications for predicting microbial activity in clouds, the bulk atmosphere on Earth, and for modeling the forward contamination of planetary surfaces like Mars. Here we describe experiments on the recovery and identification of 23 species of bacterial hypobarophiles (def., growth under hypobaric conditions of approximately 1-2 kPa) in 11 genera capable of growth at 0.7 kPa. Hypobarophilic bacteria, but not archaea or fungi, were recovered from soil and non-soil ecosystems. The highest numbers of hypobarophiles were recovered from Arctic soil, Siberian permafrost, and human saliva. Isolates were identified through 16S rRNA sequencing to belong to the genera Carnobacterium, Exiguobacterium, Leuconostoc, Paenibacillus, and Trichococcus. The highest population of culturable hypobarophilic bacteria (5.1 x 104 cfu/g) was recovered from Colour Lake soils from Axel Heiberg Island in the Canadian arctic. In addition, we extend the number of hypobarophilic species in the genus Serratia to 6 type-strains that include S. ficaria, S. fonticola, S. grimesii, S. liquefaciens, S. plymuthica, and S. quinivorans. Microbial growth at 0.7 kPa suggests that pressure alone will not be growth-limiting on the martian surface, or in Earth's atmosphere up to an altitude of 34 km.
    Keywords: Life Sciences (General)
    Type: ARC-E-DAA-TN28724 , Astrobiology (ISSN 1531-1074) (e-ISSN 1557-8070); 16; 5; 335-347
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  • 99
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    In:  Other Sources
    Publication Date: 2019-08-05
    Description: No abstract available
    Keywords: Spacecraft Design, Testing and Performance
    Type: JPL-CL-16-0925 , IEEE Aerospace Conference; Mar 05, 2016 - Mar 12, 2016; Big Sky, MT; United States
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  • 100
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    Unknown
    In:  Other Sources
    Publication Date: 2019-08-05
    Description: No abstract available
    Keywords: Spacecraft Design, Testing and Performance
    Type: JPL-CL-16-0860 , IEEE Aerospace Conference; Mar 05, 2016 - Mar 12, 2016; Big Sky, MT; United States
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