Publication Date:
2013-12-18
Description:
How biological systems generate reproducible patterns with high precision is a central question in science. The shoot apical meristem (SAM), a specialized tissue producing plant aerial organs, is a developmental system of choice to address this question. Organs are periodically initiated at the SAM at specific spatial positions and this spatiotemporal pattern defines phyllotaxis. Accumulation of the plant hormone auxin triggers organ initiation, whereas auxin depletion around organs generates inhibitory fields that are thought to be sufficient to maintain these patterns and their dynamics. Here we show that another type of hormone-based inhibitory fields, generated directly downstream of auxin by intercellular movement of the cytokinin signalling inhibitor ARABIDOPSIS HISTIDINE PHOSPHOTRANSFER PROTEIN 6 (AHP6), is involved in regulating phyllotactic patterns. We demonstrate that AHP6-based fields establish patterns of cytokinin signalling in the meristem that contribute to the robustness of phyllotaxis by imposing a temporal sequence on organ initiation. Our findings indicate that not one but two distinct hormone-based fields may be required for achieving temporal precision during formation of reiterative structures at the SAM, thus indicating an original mechanism for providing robustness to a dynamic developmental system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Besnard, Fabrice -- Refahi, Yassin -- Morin, Valerie -- Marteaux, Benjamin -- Brunoud, Geraldine -- Chambrier, Pierre -- Rozier, Frederique -- Mirabet, Vincent -- Legrand, Jonathan -- Laine, Stephanie -- Thevenon, Emmanuel -- Farcot, Etienne -- Cellier, Coralie -- Das, Pradeep -- Bishopp, Anthony -- Dumas, Renaud -- Parcy, Francois -- Helariutta, Yka -- Boudaoud, Arezki -- Godin, Christophe -- Traas, Jan -- Guedon, Yann -- Vernoux, Teva -- England -- Nature. 2014 Jan 16;505(7483):417-21. doi: 10.1038/nature12791. Epub 2013 Dec 15.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉1] Laboratoire de Reproduction et Developpement des Plantes, CNRS, INRA, ENS Lyon, UCBL, Universite de Lyon, 69364 Lyon, France [2] IBENS, ENS, 75005 Paris, France (F.B.); UMR CNRS 5534, Universite Claude Bernard Lyon I, Batiment Gregor Mendel, 16 rue Raphael Dubois, 69622 Villeurbanne, France (V.M.); University of Nottingham, University Park, Nottingham NG7 2RD, UK (E.F); University of Nottingham, Sutton Bonington LE12 5RD, UK (A.Bi.). ; Virtual Plants INRIA/CIRAD/INRA Project Team, UMR AGAP, Institut de Biologie Computationelle, 34095 Montpellier, France. ; 1] Laboratoire de Reproduction et Developpement des Plantes, CNRS, INRA, ENS Lyon, UCBL, Universite de Lyon, 69364 Lyon, France [2] IBENS, ENS, 75005 Paris, France (F.B.); UMR CNRS 5534, Universite Claude Bernard Lyon I, Batiment Gregor Mendel, 16 rue Raphael Dubois, 69622 Villeurbanne, France (V.M.); University of Nottingham, University Park, Nottingham NG7 2RD, UK (E.F); University of Nottingham, Sutton Bonington LE12 5RD, UK (A.Bi.). [3]. ; 1] Laboratoire de Reproduction et Developpement des Plantes, CNRS, INRA, ENS Lyon, UCBL, Universite de Lyon, 69364 Lyon, France [2]. ; Laboratoire de Reproduction et Developpement des Plantes, CNRS, INRA, ENS Lyon, UCBL, Universite de Lyon, 69364 Lyon, France. ; 1] Laboratoire de Reproduction et Developpement des Plantes, CNRS, INRA, ENS Lyon, UCBL, Universite de Lyon, 69364 Lyon, France [2] Laboratoire Joliot-Curie, CNRS, ENS Lyon, Universite de Lyon, 69364 Lyon, France. ; 1] Laboratoire de Reproduction et Developpement des Plantes, CNRS, INRA, ENS Lyon, UCBL, Universite de Lyon, 69364 Lyon, France [2] Virtual Plants INRIA/CIRAD/INRA Project Team, UMR AGAP, Institut de Biologie Computationelle, 34095 Montpellier, France [3] Laboratoire Joliot-Curie, CNRS, ENS Lyon, Universite de Lyon, 69364 Lyon, France. ; Laboratoire Physiologie Cellulaire et Vegetale, CEA, CNRS, INRA, UJF, 38041 Grenoble, France. ; 1] Virtual Plants INRIA/CIRAD/INRA Project Team, UMR AGAP, Institut de Biologie Computationelle, 34095 Montpellier, France [2] IBENS, ENS, 75005 Paris, France (F.B.); UMR CNRS 5534, Universite Claude Bernard Lyon I, Batiment Gregor Mendel, 16 rue Raphael Dubois, 69622 Villeurbanne, France (V.M.); University of Nottingham, University Park, Nottingham NG7 2RD, UK (E.F); University of Nottingham, Sutton Bonington LE12 5RD, UK (A.Bi.). ; 1] Institute of Biotechnology/Department of Biosciences, University of Helsinki, FIN-00014, Finland [2] IBENS, ENS, 75005 Paris, France (F.B.); UMR CNRS 5534, Universite Claude Bernard Lyon I, Batiment Gregor Mendel, 16 rue Raphael Dubois, 69622 Villeurbanne, France (V.M.); University of Nottingham, University Park, Nottingham NG7 2RD, UK (E.F); University of Nottingham, Sutton Bonington LE12 5RD, UK (A.Bi.). ; Institute of Biotechnology/Department of Biosciences, University of Helsinki, FIN-00014, Finland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24336201" target="_blank"〉PubMed〈/a〉
Keywords:
Arabidopsis/anatomy & histology/cytology/*growth & development/*metabolism
;
Arabidopsis Proteins/*metabolism
;
*Biological Transport
;
Cytokinins/*antagonists & inhibitors/metabolism
;
Indoleacetic Acids/metabolism
;
Meristem/metabolism
;
Plant Growth Regulators/antagonists & inhibitors/metabolism
;
Plant Shoots/metabolism
;
*Signal Transduction
Print ISSN:
0028-0836
Electronic ISSN:
1476-4687
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
,
Natural Sciences in General
,
Physics
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