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  • Articles  (281)
  • United States  (223)
  • Protein Conformation  (58)
  • 2005-2009  (281)
  • 2005  (281)
  • Physics  (281)
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  • Articles  (281)
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  • 2005-2009  (281)
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  • 1
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    NIH training grants. Universities may have to pay more in support of graduate training (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-12-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bhattacharjee, Yudhijit -- New York, N.Y. -- Science. 2005 Dec 9;310(5754):1601.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16339419" target="_blank"〉PubMed〈/a〉
    Keywords: Budgets ; Education, Graduate/*economics ; Financing, Government ; National Institutes of Health (U.S.)/*economics ; *Training Support ; United States ; Universities/*economics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Inferences of competence from faces predict election outcomes (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-06-11
    Description: We show that inferences of competence based solely on facial appearance predicted the outcomes of U.S. congressional elections better than chance (e.g., 68.8% of the Senate races in 2004) and also were linearly related to the margin of victory. These inferences were specific to competence and occurred within a 1-second exposure to the faces of the candidates. The findings suggest that rapid, unreflective trait inferences can contribute to voting choices, which are widely assumed to be based primarily on rational and deliberative considerations.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Todorov, Alexander -- Mandisodza, Anesu N -- Goren, Amir -- Hall, Crystal C -- New York, N.Y. -- Science. 2005 Jun 10;308(5728):1623-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychology, Princeton University, Princeton, NJ 08544, USA. atodorov@princeton.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15947187" target="_blank"〉PubMed〈/a〉
    Keywords: Aging ; Character ; Decision Making ; *Face/anatomy & histology ; Federal Government ; Female ; Forecasting ; Humans ; Intelligence ; Judgment ; Leadership ; Male ; *Mental Competency ; *Politics ; *Social Perception ; Stereotyping ; Trust ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Scientific publication. HHS Asks PNAS to pull bioterrorism paper (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-06-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, Jon -- New York, N.Y. -- Science. 2005 Jun 3;308(5727):1395.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15933172" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Bioterrorism/prevention & control ; Botulinum Toxins ; Food Supply ; Humans ; Milk ; *Periodicals as Topic ; Publishing ; *Retraction of Publication as Topic ; United States ; *United States Dept. of Health and Human Services
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Ecology. Savannah River Lab faces budget ax (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-03-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kintisch, Eli -- New York, N.Y. -- Science. 2005 Mar 25;307(5717):1857.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15790820" target="_blank"〉PubMed〈/a〉
    Keywords: *Budgets ; *Ecology ; Georgia ; *Laboratories ; Radioactive Pollutants ; *Rivers ; United States ; United States Government Agencies ; Universities
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Science and society. Smithsonian gives grudging ok to film backing ID argument (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-06-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bhattacharjee, Yudhijit -- New York, N.Y. -- Science. 2005 Jun 10;308(5728):1526.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15947141" target="_blank"〉PubMed〈/a〉
    Keywords: *Earth (Planet) ; *Evolution, Planetary ; *Motion Pictures as Topic ; *Museums ; Natural History ; Religion and Science ; *Science ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Scientific misconduct. Researcher faces prison for fraud in NIH grant applications and papers (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-03-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kintisch, Eli -- New York, N.Y. -- Science. 2005 Mar 25;307(5717):1851.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15790813" target="_blank"〉PubMed〈/a〉
    Keywords: Aging ; Energy Metabolism ; Female ; Fraud ; History, 20th Century ; History, 21st Century ; Humans ; Menopause ; *National Institutes of Health (U.S.) ; *Publishing ; *Research Support as Topic ; Retraction of Publication as Topic ; *Scientific Misconduct ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-12-17
    Description: Translesion synthesis (TLS) is the major pathway by which mammalian cells replicate across DNA lesions. Upon DNA damage, ubiquitination of proliferating cell nuclear antigen (PCNA) induces bypass of the lesion by directing the replication machinery into the TLS pathway. Yet, how this modification is recognized and interpreted in the cell remains unclear. Here we describe the identification of two ubiquitin (Ub)-binding domains (UBM and UBZ), which are evolutionarily conserved in all Y-family TLS polymerases (pols). These domains are required for binding of poleta and poliota to ubiquitin, their accumulation in replication factories, and their interaction with monoubiquitinated PCNA. Moreover, the UBZ domain of poleta is essential to efficiently restore a normal response to ultraviolet irradiation in xeroderma pigmentosum variant (XP-V) fibroblasts. Our results indicate that Ub-binding domains of Y-family polymerases play crucial regulatory roles in TLS.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bienko, Marzena -- Green, Catherine M -- Crosetto, Nicola -- Rudolf, Fabian -- Zapart, Grzegorz -- Coull, Barry -- Kannouche, Patricia -- Wider, Gerhard -- Peter, Matthias -- Lehmann, Alan R -- Hofmann, Kay -- Dikic, Ivan -- New York, N.Y. -- Science. 2005 Dec 16;310(5755):1821-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Biochemistry II, Goethe University Medical School, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16357261" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Motifs ; Amino Acid Sequence ; Animals ; Cell Line ; Computational Biology ; DNA/*biosynthesis ; *DNA Damage ; DNA Repair ; DNA Replication ; DNA-Directed DNA Polymerase/*chemistry/genetics/*metabolism ; Humans ; Hydrophobic and Hydrophilic Interactions ; Models, Molecular ; Molecular Sequence Data ; Mutation ; Nuclear Magnetic Resonance, Biomolecular ; Point Mutation ; Proliferating Cell Nuclear Antigen/metabolism ; Protein Binding ; Protein Conformation ; Protein Interaction Mapping ; Protein Structure, Tertiary ; Recombinant Fusion Proteins/metabolism ; Transfection ; Ubiquitin/*metabolism ; Xeroderma Pigmentosum/genetics ; Zinc Fingers
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    Veterans affairs. Gene bank proposal draws support--and a competitor (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-07-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin, Jennifer -- New York, N.Y. -- Science. 2005 Jul 29;309(5735):684-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16051760" target="_blank"〉PubMed〈/a〉
    Keywords: *Biological Specimen Banks ; Blood Specimen Collection ; *Dna ; *Databases, Genetic ; Genetic Privacy ; Humans ; *Medical Records Systems, Computerized ; New York ; United States ; *United States Department of Veterans Affairs ; *Universities ; *Veterans
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    Abuse of prisoners at Abu Ghraib (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-03-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kone-Cni, Vladimir J -- New York, N.Y. -- Science. 2005 Mar 25;307(5717):1873-5; author reply 1873-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15793900" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; Iraq ; *Prisoners ; *Psychology, Social ; *Torture ; United States ; Warfare
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    Communication. Social values and the governance of science (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-12-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gaskell, George -- Einsiedel, Edna -- Hallman, William -- Priest, Susanna Hornig -- Jackson, Jonathan -- Olsthoorn, Johannus -- New York, N.Y. -- Science. 2005 Dec 23;310(5756):1908-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Methodology Institute, London School of Economics and Political Science, London WC2A 2AE, UK. g.gaskell@lse.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16373561" target="_blank"〉PubMed〈/a〉
    Keywords: Canada ; Data Collection ; Europe ; Food, Genetically Modified ; Public Opinion ; *Public Policy ; *Science ; *Social Values ; Stem Cells ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 11
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    Drug safety. FDA panel urges caution on many anti-inflammatory drugs (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-02-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin, Jennifer -- New York, N.Y. -- Science. 2005 Feb 25;307(5713):1183-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15731414" target="_blank"〉PubMed〈/a〉
    Keywords: *Advisory Committees ; Anti-Inflammatory Agents, Non-Steroidal/adverse effects/therapeutic use ; Cardiovascular Diseases/chemically induced/epidemiology ; Celecoxib ; Cyclooxygenase Inhibitors/*adverse effects/*therapeutic use ; *Drug Labeling ; Drug and Narcotic Control ; Humans ; Isoxazoles/adverse effects/therapeutic use ; Lactones/adverse effects/therapeutic use ; Pyrazoles/adverse effects/therapeutic use ; Stroke/chemically induced/epidemiology ; Sulfonamides/adverse effects/therapeutic use ; Sulfones/adverse effects/therapeutic use ; United States ; *United States Food and Drug Administration
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 12
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    Asian scientists and the "glass ceiling" (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-12-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jiang, Dianhua -- New York, N.Y. -- Science. 2005 Dec 16;310(5755):1767-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16363028" target="_blank"〉PubMed〈/a〉
    Keywords: Asia/ethnology ; *Asian Americans ; *Career Mobility ; *Foreign Professional Personnel ; Humans ; Science/*manpower ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 13
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    High-risk research. Six women among 13 NIH 'Pioneers' (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-10-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- New York, N.Y. -- Science. 2005 Sep 30;309(5744):2149.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16195437" target="_blank"〉PubMed〈/a〉
    Keywords: *Awards and Prizes ; *Biomedical Research ; Female ; Humans ; Male ; *National Institutes of Health (U.S.) ; *Research Personnel ; United States ; *Women
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 14
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    AIDS research. IOM panel clears HIV prevention study (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-04-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin, Jennifer -- New York, N.Y. -- Science. 2005 Apr 15;308(5720):334.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15831722" target="_blank"〉PubMed〈/a〉
    Keywords: Anti-HIV Agents/administration & dosage/adverse effects/*therapeutic use ; *Clinical Trials as Topic/standards ; Female ; HIV Infections/drug therapy/*prevention & control/*transmission ; Humans ; Infant, Newborn ; Infectious Disease Transmission, Vertical/*prevention & control ; Institute of Medicine (U.S.) ; National Institutes of Health (U.S.) ; Nevirapine/administration & dosage/adverse effects/*therapeutic use ; Pilot Projects ; Pregnancy ; Pregnancy Complications, Infectious/drug therapy ; Uganda ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 15
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    Nanotechnology. Calls rise for more research on toxicology of nanomaterials (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-12-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Service, Robert F -- New York, N.Y. -- Science. 2005 Dec 9;310(5754):1609.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16339426" target="_blank"〉PubMed〈/a〉
    Keywords: Budgets ; *Environment ; Financing, Government ; Great Britain ; Humans ; International Cooperation ; Nanostructures/*toxicity ; *Nanotechnology ; Occupational Exposure ; *Research ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 16
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    Structural biology. Structural genomics, round 2 (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-03-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Service, Robert -- New York, N.Y. -- Science. 2005 Mar 11;307(5715):1554-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15761136" target="_blank"〉PubMed〈/a〉
    Keywords: Automation ; Biomedical Technology ; Budgets ; Computer Simulation ; Costs and Cost Analysis ; Crystallization ; Crystallography, X-Ray ; *Genomics/economics/instrumentation/methods ; Models, Molecular ; National Institutes of Health (U.S.)/economics ; *Protein Conformation ; Proteins/*chemistry/genetics/isolation & purification ; *Proteomics/economics/instrumentation/methods ; Robotics ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 17
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    Research funding. Centers of attention: NSF takes fresh look at their proliferation (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-05-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- New York, N.Y. -- Science. 2005 May 13;308(5724):943-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15890857" target="_blank"〉PubMed〈/a〉
    Keywords: Budgets ; Financing, Government ; *Research Support as Topic ; Science/education ; United States ; *United States Government Agencies
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 18
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    Stem cells. Deriving 'controversy-free' ES cells is controversial (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-10-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vogel, Gretchen -- New York, N.Y. -- Science. 2005 Oct 21;310(5747):416-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16239442" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blastocyst/cytology ; *Cell Line ; Embryo Implantation ; Embryo Research/economics/*ethics ; Embryo, Mammalian/*cytology ; Female ; Financing, Government ; Humans ; Mice ; Nuclear Transfer Techniques ; *Pluripotent Stem Cells ; Research Support as Topic ; *Stem Cells ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 19
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    Pediatric medicine. Europe follows U.S. in testing drugs for children (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-09-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bosch, Xavier -- New York, N.Y. -- Science. 2005 Sep 16;309(5742):1799.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16166486" target="_blank"〉PubMed〈/a〉
    Keywords: Advisory Committees ; Child ; *Clinical Trials as Topic ; *Drug Approval ; *European Union ; Humans ; *Legislation, Drug ; *Pediatrics ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 20
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    National Institutes of Health. NIH aims to create 'homes' for clinical science (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-10-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2005 Oct 21;310(5747):422-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16239450" target="_blank"〉PubMed〈/a〉
    Keywords: Biomedical Research/education/*organization & administration ; Financing, Government ; National Institutes of Health (U.S.)/*organization & administration ; *Research Support as Topic ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 21
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    Arguing about the use of stem cells (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-07-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bradford, Barry -- New York, N.Y. -- Science. 2005 Jul 1;309(5731):51.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15994508" target="_blank"〉PubMed〈/a〉
    Keywords: Beginning of Human Life ; Christianity ; Embryo Research/*ethics ; Humans ; *Stem Cells ; United States
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    Biodefense. Critics question proposed countermeasures agency (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-11-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2005 Nov 4;310(5749):755.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16272086" target="_blank"〉PubMed〈/a〉
    Keywords: Access to Information ; *Anti-Infective Agents ; *Bioterrorism ; Communicable Diseases/drug therapy ; Financing, Government ; Humans ; National Institutes of Health (U.S.) ; Research Support as Topic ; United States ; United States Dept. of Health and Human Services/*legislation & ; jurisprudence/*organization & administration ; *Vaccines
    Print ISSN: 0036-8075
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    Epidemiology. Regulations spark technology competition (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-03-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Granmar, Marie -- New York, N.Y. -- Science. 2005 Mar 25;307(5717):1860.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15790824" target="_blank"〉PubMed〈/a〉
    Keywords: Air Pollution/*prevention & control ; Filtration/instrumentation ; *Gasoline ; Government Regulation ; *Industry ; Particle Size ; United States ; United States Environmental Protection Agency ; Vehicle Emissions/*prevention & control/toxicity
    Print ISSN: 0036-8075
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    U.S. budget. NIH set for tiny spending hike in 2006 (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-11-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2005 Nov 25;310(5752):1256.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16311303" target="_blank"〉PubMed〈/a〉
    Keywords: Advisory Committees ; *Budgets/legislation & jurisprudence ; Financing, Government ; National Institutes of Health (U.S.)/*economics ; Research Support as Topic ; United States
    Print ISSN: 0036-8075
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    Public health. Pandemic or not, experts welcome Bush flu plan (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-11-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2005 Nov 11;310(5750):952-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16284148" target="_blank"〉PubMed〈/a〉
    Keywords: Antiviral Agents/*supply & distribution ; Cell Line ; *Disease Outbreaks/prevention & control ; Financing, Government ; Humans ; Influenza A Virus, H5N1 Subtype/growth & development/immunology/pathogenicity ; Influenza A virus/growth & development/immunology ; Influenza Vaccines/*economics ; Influenza, Human/drug therapy/*epidemiology/prevention & control/*virology ; United States ; Virus Cultivation
    Print ISSN: 0036-8075
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    Virology. Resurrected influenza virus yields secrets of deadly 1918 pandemic (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-10-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2005 Oct 7;310(5745):28-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16210501" target="_blank"〉PubMed〈/a〉
    Keywords: Advisory Committees ; Animals ; Bioterrorism ; Chick Embryo/virology ; Containment of Biohazards ; Disease Outbreaks/history ; Editorial Policies ; *Genes, Viral ; Genome, Viral ; Hemagglutinin Glycoproteins, Influenza Virus/chemistry/*metabolism ; History, 20th Century ; Humans ; Influenza A virus/*genetics/*pathogenicity/physiology ; Influenza, Human/epidemiology/history/*virology ; Mice ; Neuraminidase/genetics/metabolism ; Publishing ; RNA Replicase/genetics/metabolism ; United States ; Virulence ; Virus Replication
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Bioinformatics. With a stumble, Microsoft launches European research project (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-02-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vogel, Gretchen -- New York, N.Y. -- Science. 2005 Feb 11;307(5711):828.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15705815" target="_blank"〉PubMed〈/a〉
    Keywords: *Academies and Institutes/economics ; *Computational Biology ; *Computers ; Europe ; *Research Support as Topic ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Conflict of interest. Forty-four researchers broke NIH consulting rules (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-07-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2005 Jul 22;309(5734):546.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16040681" target="_blank"〉PubMed〈/a〉
    Keywords: *Conflict of Interest ; *Consultants ; *Ethics, Professional ; *National Institutes of Health (U.S.) ; Research Personnel/*ethics ; United States
    Print ISSN: 0036-8075
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    Space science. NASA starts squeezing to fit missions into tight budget (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-12-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lawler, Andrew -- New York, N.Y. -- Science. 2005 Dec 9;310(5754):1594-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16339413" target="_blank"〉PubMed〈/a〉
    Keywords: Biological Science Disciplines ; *Budgets ; Financing, Government ; Natural Science Disciplines ; *Research/economics ; *Space Flight/economics ; Spacecraft ; United States ; United States National Aeronautics and Space ; Administration/*economics/organization & administration
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Microbiology. Translocation of anthrax toxin: lord of the rings (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-07-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉von Heijne, Gunnar -- New York, N.Y. -- Science. 2005 Jul 29;309(5735):709-10.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry and Biophysics, Stockholm University, SE-10691 Stockholm, Sweden. gunnar@dbb.su.se〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16051774" target="_blank"〉PubMed〈/a〉
    Keywords: Alanine/chemistry ; Amino Acid Substitution ; Antigens, Bacterial/*chemistry/genetics/*metabolism ; Bacillus anthracis/*chemistry/metabolism ; Bacterial Toxins/*chemistry/genetics/*metabolism ; Cell Membrane/*metabolism ; Cytosol/metabolism ; Hydrogen-Ion Concentration ; Hydrophobic and Hydrophilic Interactions ; Mutation ; Onium Compounds/metabolism ; Organophosphorus Compounds/metabolism ; Phenylalanine/*chemistry ; Protein Conformation ; Protein Folding ; Quaternary Ammonium Compounds/metabolism
    Print ISSN: 0036-8075
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    Space and earth sciences. Budget woes greet NASA science chief (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-08-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lawler, Andrew -- New York, N.Y. -- Science. 2005 Aug 19;309(5738):1165.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16109854" target="_blank"〉PubMed〈/a〉
    Keywords: Astronomy ; Biological Science Disciplines ; *Budgets ; History, 20th Century ; History, 21st Century ; Research ; United States ; United States National Aeronautics and Space ; Administration/economics/history/*organization & administration
    Print ISSN: 0036-8075
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    Taxonomy. Taxonomy's elusive grail (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-02-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Miller, Greg -- New York, N.Y. -- Science. 2005 Feb 18;307(5712):1038.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15718448" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biodiversity ; *Classification ; Costa Rica ; Financial Support ; *Phylogeny ; Sweden ; United States
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    Abuse of prisoners at Abu Ghraib (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-03-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Persaud, Raj -- New York, N.Y. -- Science. 2005 Mar 25;307(5717):1873-5; author reply 1873-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15793899" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; Iraq ; Military Personnel/*psychology ; Politics ; *Prisoners ; *Psychology, Social ; Torture/*psychology ; United States
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  • 34
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    Self-propagating, molecular-level polymorphism in Alzheimer's beta-amyloid fibrils (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-01-18
    Description: Amyloid fibrils commonly exhibit multiple distinct morphologies in electron microscope and atomic force microscope images, often within a single image field. By using electron microscopy and solid-state nuclear magnetic resonance measurements on fibrils formed by the 40-residue beta-amyloid peptide of Alzheimer's disease (Abeta(1-40)), we show that different fibril morphologies have different underlying molecular structures, that the predominant structure can be controlled by subtle variations in fibril growth conditions, and that both morphology and molecular structure are self-propagating when fibrils grow from preformed seeds. Different Abeta(1-40) fibril morphologies also have significantly different toxicities in neuronal cell cultures. These results have implications for the mechanism of amyloid formation, the phenomenon of strains in prion diseases, the role of amyloid fibrils in amyloid diseases, and the development of amyloid-based nano-materials.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Petkova, Aneta T -- Leapman, Richard D -- Guo, Zhihong -- Yau, Wai-Ming -- Mattson, Mark P -- Tycko, Robert -- New York, N.Y. -- Science. 2005 Jan 14;307(5707):262-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health (NIH), Bethesda, MD 20892-0520, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15653506" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Motifs ; Amyloid beta-Peptides/*chemistry/toxicity/*ultrastructure ; Animals ; Cells, Cultured ; Chemistry, Physical ; Hippocampus/cytology ; Humans ; Hydrogen Bonding ; Microscopy, Atomic Force ; Microscopy, Electron, Transmission ; Molecular Structure ; Neurons/cytology/drug effects ; Nuclear Magnetic Resonance, Biomolecular ; Peptide Fragments/*chemistry/toxicity/*ultrastructure ; Physicochemical Phenomena ; Protein Conformation ; Protein Structure, Secondary ; Rats
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    Revisiting the taxonomic impediment (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-01-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉de Carvalho, Marcelo R -- Bockmann, Flavio A -- Amorim, Dalton S -- de Vivo, Mario -- de Toledo-Piza, Monica -- Menezes, Naercio A -- de Figueiredo, Jose L -- Castro, Ricardo M C -- Gill, Anthony C -- McEachran, John D -- Compagno, Leonard J V -- Schelly, Robert C -- Britz, Ralf -- Lundberg, John G -- Vari, Richard P -- Nelson, Gareth -- New York, N.Y. -- Science. 2005 Jan 21;307(5708):353.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15661993" target="_blank"〉PubMed〈/a〉
    Keywords: *Biodiversity ; Biology/education/manpower ; *Classification ; Conservation of Natural Resources ; Developing Countries ; Latin America ; United States
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    U.S. military facilities. Pathology institute hit in base-closing plan (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-05-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2005 May 20;308(5725):1101.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15905373" target="_blank"〉PubMed〈/a〉
    Keywords: Biological Specimen Banks ; *Military Medicine ; Museums ; *Pathology ; United States
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    Multiple transatlantic introductions of the western corn rootworm (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-11-15
    Description: The invasion of Europe by the western corn rootworm, North America's most destructive corn pest, is ongoing and represents a serious threat to European agriculture. Because this pest was initially introduced in Central Europe, it was believed that subsequent outbreaks in Western Europe originated from this area. Using model-based Bayesian analyses of the genetic variability of the western corn rootworm, we demonstrate that this belief is false: There have been at least three independent introductions from North America during the past two decades. This result raises questions about changing circumstances that have enabled a sudden burst of transatlantic introductions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Miller, Nicholas -- Estoup, Arnaud -- Toepfer, Stefan -- Bourguet, Denis -- Lapchin, Laurent -- Derridj, Sylvie -- Kim, Kyung Seok -- Reynaud, Philippe -- Furlan, Lorenzo -- Guillemaud, Thomas -- New York, N.Y. -- Science. 2005 Nov 11;310(5750):992.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Biologie des Populations en Interaction, Unite Mixte de Recherche (UMR) 1112 Institute National de la Recherche Agronomique (INRA)-Universite de Nice-Sophia Antipolis, 400 Route des Chappes, 06903 Sophia Antipolis Cedex, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16284172" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bayes Theorem ; *Beetles/genetics ; Computer Simulation ; Europe ; Genetic Variation ; Insect Control ; Microsatellite Repeats ; North America ; Population Dynamics ; United States ; *Zea mays
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    Structural biology. Flipping lipids: is the third time the charm? (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-05-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Davidson, Amy L -- Chen, Jue -- New York, N.Y. -- Science. 2005 May 13;308(5724):963-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA. davidson@bcm.tmc.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15890866" target="_blank"〉PubMed〈/a〉
    Keywords: ATP-Binding Cassette Transporters/*chemistry/*metabolism ; Adenosine Diphosphate/metabolism ; Adenosine Triphosphate/metabolism ; Amino Acid Motifs ; Bacterial Proteins/*chemistry/*metabolism ; Cell Membrane/*chemistry ; Crystallography, X-Ray ; Dimerization ; Electron Spin Resonance Spectroscopy ; Escherichia coli/chemistry ; Escherichia coli Proteins/chemistry/metabolism ; Hydrolysis ; Lipid A/metabolism ; Lipid Bilayers ; Models, Molecular ; Protein Conformation ; Protein Folding ; Protein Structure, Tertiary ; Salmonella typhimurium/*chemistry ; Spin Labels ; Vanadates/metabolism
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    NASA. Life science research on space station is headed for big cuts (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-04-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lawler, Andrew -- New York, N.Y. -- Science. 2005 Apr 29;308(5722):610-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15860595" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Astronauts ; *Biological Science Disciplines ; Humans ; *Research/economics ; Research Support as Topic ; *Space Flight ; *Spacecraft ; United States ; *United States National Aeronautics and Space ; Administration/economics/organization & administration
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Asian scientists and the "glass ceiling" (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-12-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pike, Linda J -- New York, N.Y. -- Science. 2005 Dec 16;310(5755):1767-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16363030" target="_blank"〉PubMed〈/a〉
    Keywords: Asia/ethnology ; *Asian Americans ; *Career Mobility ; *Foreign Professional Personnel ; Humans ; Science/*manpower ; *Societies, Scientific/organization & administration ; United States
    Print ISSN: 0036-8075
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  • 41
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    Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-11-19
    Description: Interleukin-2 (IL-2) is an immunoregulatory cytokine that acts through a quaternary receptor signaling complex containing alpha (IL-2Ralpha), beta (IL-2Rbeta), and common gamma chain (gc) receptors. In the structure of the quaternary ectodomain complex as visualized at a resolution of 2.3 angstroms, the binding of IL-2Ralpha to IL-2 stabilizes a secondary binding site for presentation to IL-2Rbeta. gammac is then recruited to the composite surface formed by the IL-2/IL-2Rbeta complex. Consistent with its role as a shared receptor for IL-4, IL-7, IL-9, IL-15, and IL-21, gammac forms degenerate contacts with IL-2. The structure of gammac provides a rationale for loss-of-function mutations found in patients with X-linked severe combined immunodeficiency diseases (X-SCID). This complex structure provides a framework for other gammac-dependent cytokine-receptor interactions and for the engineering of improved IL-2 therapeutics.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wang, Xinquan -- Rickert, Mathias -- Garcia, K Christopher -- AI51321/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2005 Nov 18;310(5751):1159-63.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Department of Microbiology and Immunology, Stanford University School of Medicine, 299 Campus Drive, Fairchild D319, Stanford, CA 94305, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16293754" target="_blank"〉PubMed〈/a〉
    Keywords: Crystallography, X-Ray ; Humans ; Interleukin Receptor Common gamma Subunit ; Interleukin-2/*chemistry/metabolism/therapeutic use ; Interleukin-2 Receptor alpha Subunit ; Interleukin-2 Receptor beta Subunit ; Models, Molecular ; Mutation ; Protein Binding ; Protein Conformation ; Receptors, Interleukin/*chemistry/metabolism ; Receptors, Interleukin-2/*chemistry/genetics/metabolism ; Recombinant Proteins/therapeutic use ; Severe Combined Immunodeficiency/genetics
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    Nurturing the next Einsteins (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-02-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Alexander, Lamar -- New York, N.Y. -- Science. 2005 Feb 18;307(5712):1013.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15718431" target="_blank"〉PubMed〈/a〉
    Keywords: Biological Science Disciplines ; Education, Graduate ; Engineering/*education ; Natural Science Disciplines/*education ; *Research ; *Research Support as Topic ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Gene therapy. Panel urges limits on X-SCID trials (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-03-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2005 Mar 11;307(5715):1544-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15761128" target="_blank"〉PubMed〈/a〉
    Keywords: Advisory Committees ; Animals ; *Clinical Trials as Topic ; Genetic Diseases, X-Linked/*therapy ; *Genetic Therapy/adverse effects ; Genetic Vectors ; Haplorhini ; Humans ; Infant ; Leukemia, T-Cell/etiology ; Mice ; Oncogenes ; Retroviridae/genetics ; Severe Combined Immunodeficiency/*therapy ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Conflicts of interest. NIH scientists raise fuss about scope of new rules (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-03-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2005 Mar 4;307(5714):1390.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15746396" target="_blank"〉PubMed〈/a〉
    Keywords: *Conflict of Interest ; Consultants ; Drug Industry ; Investments ; National Institutes of Health (U.S.)/*ethics ; Research Personnel/*ethics ; United States
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    Global voices of science. Teaching evolution in Mexico: preaching to the choir (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-11-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lazcano, Antonio -- New York, N.Y. -- Science. 2005 Nov 4;310(5749):787-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Facultad de Ciencias, UNAM, Apdo. Postal 70-407, Cd. Universitaria, Mexico D.F., 04510 Mexico. alar@correo.unam.mx〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16272103" target="_blank"〉PubMed〈/a〉
    Keywords: *Biological Evolution ; Biology/*education ; *Catholicism ; Christianity ; International Cooperation ; Mexico ; Origin of Life ; *Religion and Science ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Crystal structure of the malaria vaccine candidate apical membrane antigen 1 (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-02-26
    Description: Apical membrane antigen 1 from Plasmodium is a leading malaria vaccine candidate. The protein is essential for host-cell invasion, but its molecular function is unknown. The crystal structure of the three domains comprising the ectoplasmic region of the antigen from P. vivax, solved at 1.8 angstrom resolution, shows that domains I and II belong to the PAN motif, which defines a superfamily of protein folds implicated in receptor binding. We also mapped the epitope of an invasion-inhibitory monoclonal antibody specific for the P. falciparum ortholog and modeled this to the structure. The location of the epitope and current knowledge on structure-function correlations for PAN domains together suggest a receptor-binding role during invasion in which domain II plays a critical part. These results are likely to aid vaccine and drug design.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pizarro, Juan Carlos -- Vulliez-Le Normand, Brigitte -- Chesne-Seck, Marie-Laure -- Collins, Christine R -- Withers-Martinez, Chrislaine -- Hackett, Fiona -- Blackman, Michael J -- Faber, Bart W -- Remarque, Edmond J -- Kocken, Clemens H M -- Thomas, Alan W -- Bentley, Graham A -- MC_U117532063/Medical Research Council/United Kingdom -- New York, N.Y. -- Science. 2005 Apr 15;308(5720):408-11. Epub 2005 Feb 24.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Unite d'Immunologie Structurale, Centre National de la Recherche Scientifique, URA 2185, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15731407" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Motifs ; Amino Acid Sequence ; Animals ; Antibodies, Monoclonal/immunology ; Antigens, Protozoan/*chemistry/immunology ; Binding Sites ; Crystallization ; Crystallography, X-Ray ; Epitope Mapping ; Epitopes ; Heparin/metabolism ; Malaria Vaccines ; Membrane Proteins/*chemistry/immunology ; Models, Molecular ; Molecular Sequence Data ; Plasmodium falciparum/chemistry/immunology ; Plasmodium vivax/chemistry/*immunology ; Protein Conformation ; Protein Folding ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Protozoan Proteins/*chemistry/immunology ; Recombinant Proteins/chemistry ; Sequence Alignment
    Print ISSN: 0036-8075
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    An open letter to Elias Zerhouni (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-03-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Altman, Sidney -- Bassler, Bonnie L -- Beckwith, Jon -- Belfort, Marlene -- Berg, Howard C -- Bloom, Barry -- Brenchley, Jean E -- Campbell, Allan -- Collier, R John -- Connell, Nancy -- Cozzarelli, Nicholas R -- Craig, Nancy L -- Darst, Seth -- Ebright, Richard H -- Elledge, Stephen J -- Falkow, Stanley -- Galan, Jorge E -- Gottesman, Max -- Gourse, Richard -- Grindley, Nigel D F -- Gross, Carol A -- Grossman, Alan -- Hochschild, Ann -- Howe, Martha -- Hurwitz, Jerard -- Isberg, Ralph R -- Kaplan, Samuel -- Kornberg, Arthur -- Kustu, Sydney G -- Landick, Robert C -- Landy, Arthur -- Levy, Stuart B -- Losick, Richard -- Long, Sharon R -- Maloy, Stanley R -- Mekalanos, John J -- Neidhardt, Frederick C -- Pace, Norman R -- Ptashne, Mark -- Roberts, Jeffrey W -- Roth, John R -- Rothman-Denes, Lucia B -- Salyers, Abigail -- Schaechter, Moselio -- Shapiro, Lucy -- Silhavy, Thomas J -- Simon, Melvin I -- Walker, Graham -- Yanofsky, Charles -- Zinder, Norton -- New York, N.Y. -- Science. 2005 Mar 4;307(5714):1409-10.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15746409" target="_blank"〉PubMed〈/a〉
    Keywords: Biological Warfare ; *Biomedical Research/economics ; *Bioterrorism ; Financing, Government ; *Microbiology ; *National Institutes of Health (U.S.) ; Peer Review, Research ; Public Health ; *Research Support as Topic ; United States
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    U.S. military installations. Base commission alters Pentagon's wishes on labs (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-09-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- Kintisch, Eli -- New York, N.Y. -- Science. 2005 Sep 2;309(5740):1472.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16141037" target="_blank"〉PubMed〈/a〉
    Keywords: *Academies and Institutes ; *Advisory Committees ; *Military Medicine ; *Pathology ; United States ; *United States Government Agencies
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    Wanted: women in clinical trials (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-06-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Simon, Viviana -- New York, N.Y. -- Science. 2005 Jun 10;308(5728):1517.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15947140" target="_blank"〉PubMed〈/a〉
    Keywords: *Clinical Trials as Topic ; Female ; Humans ; Male ; Research Design ; Research Support as Topic ; *Sex Characteristics ; United States ; *Women ; Women's Health
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    What can be done to stop the decline? (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-07-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lederman, Leon M -- New York, N.Y. -- Science. 2005 Jul 1;309(5731):51.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15994507" target="_blank"〉PubMed〈/a〉
    Keywords: Administrative Personnel ; *Education ; Science ; Technology ; United States
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    Tryptophan 7-halogenase (PrnA) structure suggests a mechanism for regioselective chlorination (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-10-01
    Description: Chlorinated natural products include vancomycin and cryptophycin A. Their biosynthesis involves regioselective chlorination by flavin-dependent halogenases. We report the structural characterization of tryptophan 7-halogenase (PrnA), which regioselectively chlorinates tryptophan. Tryptophan and flavin adenine dinucleotide (FAD) are separated by a 10 angstrom-long tunnel and bound by distinct enzyme modules. The FAD module is conserved in halogenases and is related to flavin-dependent monooxygenases. On the basis of biochemical studies, crystal structures, and by analogy with monooxygenases, we predict that FADH2 reacts with O2 to make peroxyflavin, which is decomposed by Cl-. The resulting HOCl is guided through the tunnel to tryptophan, where it is activated to participate in electrophilic aromatic substitution.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315827/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315827/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dong, Changjiang -- Flecks, Silvana -- Unversucht, Susanne -- Haupt, Caroline -- van Pee, Karl-Heinz -- Naismith, James H -- BB/C000080/1/Biotechnology and Biological Sciences Research Council/United Kingdom -- BBS/B/14426/Biotechnology and Biological Sciences Research Council/United Kingdom -- New York, N.Y. -- Science. 2005 Sep 30;309(5744):2216-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Centre for Biomolecular Sciences, EaStchem, University of St. Andrews, St. Andrews KY16 9ST, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16195462" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Binding Sites ; Chlorides/*metabolism ; Crystallography, X-Ray ; Dimerization ; Flavin-Adenine Dinucleotide/analogs & derivatives/metabolism ; Hydrogen Bonding ; Hypochlorous Acid/metabolism ; Indoles/metabolism ; Models, Molecular ; Molecular Sequence Data ; Oxidation-Reduction ; Oxidoreductases/*chemistry/isolation & purification/metabolism ; Oxygen/metabolism ; Protein Conformation ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Pseudomonas fluorescens/*enzymology ; Tryptophan/analogs & derivatives/metabolism
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    Structural roles for human translation factor eIF3 in initiation of protein synthesis (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-12-03
    Description: Protein synthesis in mammalian cells requires initiation factor eIF3, a approximately 750-kilodalton complex that controls assembly of 40S ribosomal subunits on messenger RNAs (mRNAs) bearing either a 5'-cap or an internal ribosome entry site (IRES). Cryo-electron microscopy reconstructions show that eIF3, a five-lobed particle, interacts with the hepatitis C virus (HCV) IRES RNA and the 5'-cap binding complex eIF4F via the same domain. Detailed modeling of eIF3 and eIF4F onto the 40S ribosomal subunit reveals that eIF3 uses eIF4F or the HCV IRES in structurally similar ways to position the mRNA strand near the exit site of 40S, promoting initiation complex assembly.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Siridechadilok, Bunpote -- Fraser, Christopher S -- Hall, Richard J -- Doudna, Jennifer A -- Nogales, Eva -- New York, N.Y. -- Science. 2005 Dec 2;310(5753):1513-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16322461" target="_blank"〉PubMed〈/a〉
    Keywords: Binding Sites ; Eukaryotic Initiation Factor-3/chemistry/*physiology/ultrastructure ; Eukaryotic Initiation Factor-4F/metabolism ; HeLa Cells ; Hepacivirus/genetics ; Humans ; Models, Molecular ; Protein Binding ; Protein Biosynthesis/*physiology ; Protein Conformation ; RNA, Messenger/metabolism ; RNA, Viral/metabolism ; Ribosomes/metabolism ; Structure-Activity Relationship
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    Problems in patenting human genes (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-06-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Murashige, Kate H -- New York, N.Y. -- Science. 2005 Jun 24;308(5730):1868-70; author reply 1868-70.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15976288" target="_blank"〉PubMed〈/a〉
    Keywords: *Genes ; Humans ; *Patents as Topic/legislation & jurisprudence ; Public Policy ; United States
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    Global impact of recreational fisheries (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-03-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Arlinghaus, Robert -- Cooke, Steven J -- New York, N.Y. -- Science. 2005 Mar 11;307(5715):1561-3; author reply 1561-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15765561" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Conservation of Natural Resources ; Ecosystem ; *Fisheries ; *Fishes ; Fresh Water ; Internationality ; Population Dynamics ; *Recreation ; Seawater ; United States
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    NASA: back to eating seed corn (2005)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 2005-11-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kennedy, Donald -- New York, N.Y. -- Science. 2005 Nov 25;310(5752):1245.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16311301" target="_blank"〉PubMed〈/a〉
    Keywords: *Biological Science Disciplines ; Mars ; Moon ; *Research ; *Space Flight ; United States ; *United States National Aeronautics and Space ; Administration/economics/organization & administration
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    Abuse of prisoners at Abu Ghraib (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-03-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Musch, David C -- New York, N.Y. -- Science. 2005 Mar 25;307(5717):1873-5; author reply 1873-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15793901" target="_blank"〉PubMed〈/a〉
    Keywords: *Dissent and Disputes ; Humans ; Iraq ; Peer Group ; *Prisoners ; *Social Conformity ; *Torture ; United States ; Warfare
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    Structure of SARS coronavirus spike receptor-binding domain complexed with receptor (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-09-17
    Description: The spike protein (S) of SARS coronavirus (SARS-CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction. The crystal structure at 2.9 angstrom resolution of the RBD bound with the peptidase domain of human ACE2 shows that the RBD presents a gently concave surface, which cradles the N-terminal lobe of the peptidase. The atomic details at the interface between the two proteins clarify the importance of residue changes that facilitate efficient cross-species infection and human-to-human transmission. The structure of the RBD suggests ways to make truncated disulfide-stabilized RBD variants for use in the design of coronavirus vaccines.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Li, Fang -- Li, Wenhui -- Farzan, Michael -- Harrison, Stephen C -- AI061601/AI/NIAID NIH HHS/ -- CA13202/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2005 Sep 16;309(5742):1864-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School and Laboratory of Molecular Medicine, 320 Longwood Avenue, Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16166518" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Amino Acid Substitution ; Animals ; Antibodies, Viral/immunology ; Binding Sites ; Carboxypeptidases/*chemistry/metabolism ; Cell Line ; Crystallography, X-Ray ; Disease Outbreaks ; Epitopes ; Glycosylation ; Humans ; Hydrophobic and Hydrophilic Interactions ; Membrane Glycoproteins/*chemistry/genetics/immunology/*metabolism ; Models, Molecular ; Molecular Sequence Data ; Mutation ; Peptidyl-Dipeptidase A ; Protein Conformation ; Protein Structure, Tertiary ; Receptors, Virus/*chemistry/metabolism ; SARS Virus/*chemistry/genetics/physiology ; Severe Acute Respiratory Syndrome/transmission/*virology ; Species Specificity ; Spike Glycoprotein, Coronavirus ; Viral Envelope Proteins/*chemistry/genetics/immunology/*metabolism ; Viral Vaccines ; Viverridae/virology
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    A European CDC? (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-03-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wigzell, Hans -- New York, N.Y. -- Science. 2005 Mar 18;307(5716):1691.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15774726" target="_blank"〉PubMed〈/a〉
    Keywords: Budgets ; Centers for Disease Control and Prevention (U.S.) ; Communicable Disease Control/economics/*organization & administration ; European Union/economics/*organization & administration ; Humans ; Population Surveillance ; *Public Health ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Twilight for the Enlightenment? (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-04-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kennedy, Donald -- New York, N.Y. -- Science. 2005 Apr 8;308(5719):165.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15821047" target="_blank"〉PubMed〈/a〉
    Keywords: Biological Evolution ; Biomedical Research/*trends ; Christianity ; Education/*trends ; Europe ; Politics ; Public Policy ; *Religion and Science ; Teaching ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Social Security meets race (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-09-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Liebman, Jeffrey -- New York, N.Y. -- Science. 2005 Sep 23;309(5743):1965.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16179435" target="_blank"〉PubMed〈/a〉
    Keywords: *African Americans ; *Health ; Humans ; Income ; *Life Expectancy ; *Privatization/economics ; Social Security/*economics ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Conservation policy. House revises Endangered Species Act (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-10-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stokstad, Eric -- New York, N.Y. -- Science. 2005 Oct 7;310(5745):32.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16210505" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Conservation of Natural Resources/*legislation & jurisprudence ; *Ecosystem ; Environment ; Public Policy ; United States ; United States Government Agencies
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    A fluoroquinolone resistance protein from Mycobacterium tuberculosis that mimics DNA (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-06-04
    Description: Fluoroquinolones are gaining increasing importance in the treatment of tuberculosis. The expression of MfpA, a member of the pentapeptide repeat family of proteins from Mycobacterium tuberculosis, causes resistance to ciprofloxacin and sparfloxacin. This protein binds to DNA gyrase and inhibits its activity. Its three-dimensional structure reveals a fold, which we have named the right-handed quadrilateral beta helix, that exhibits size, shape, and electrostatic similarity to B-form DNA. This represents a form of DNA mimicry and explains both its inhibitory effect on DNA gyrase and fluoroquinolone resistance resulting from the protein's expression in vivo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hegde, Subray S -- Vetting, Matthew W -- Roderick, Steven L -- Mitchenall, Lesley A -- Maxwell, Anthony -- Takiff, Howard E -- Blanchard, John S -- AI33696/AI/NIAID NIH HHS/ -- AI60899/AI/NIAID NIH HHS/ -- T32 AI007501/AI/NIAID NIH HHS/ -- T32 AI07501/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2005 Jun 3;308(5727):1480-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15933203" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Antitubercular Agents/chemistry/*pharmacology ; Bacterial Proteins/chemistry/*physiology ; Ciprofloxacin/pharmacology ; Crystallography, X-Ray ; DNA Gyrase/metabolism ; DNA, Bacterial/*chemistry ; DNA, Superhelical/chemistry ; *Drug Resistance, Bacterial ; Drug Resistance, Microbial/*physiology ; Enzyme Inhibitors/chemistry ; Escherichia coli/enzymology ; Fluoroquinolones/antagonists & inhibitors/chemistry/*pharmacology ; Models, Molecular ; *Molecular Mimicry ; Molecular Sequence Data ; Monomeric GTP-Binding Proteins ; Mycobacterium tuberculosis/drug effects/*physiology ; Protein Conformation ; Protein Folding ; Structure-Activity Relationship ; Topoisomerase II Inhibitors
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Disulfide isomerization after membrane release of its SAR domain activates P1 lysozyme (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-01-08
    Description: The P1 lysozyme Lyz is secreted to the periplasm of Escherichia coli and accumulates in an inactive membrane-tethered form. Genetic and biochemical experiments show that, when released from the bilayer, Lyz is activated by an intramolecular thiol-disulfide isomerization, which requires a cysteine in its N-terminal SAR (signal-arrest-release) domain. Crystal structures confirm the alternative disulfide linkages in the two forms of Lyz and reveal dramatic conformational differences in the catalytic domain. Thus, the exported P1 endolysin is kept inactive by three levels of control-topological, conformational, and covalent-until its release from the membrane is triggered by the P1 holin.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Xu, Min -- Arulandu, Arockiasamy -- Struck, Douglas K -- Swanson, Stephanie -- Sacchettini, James C -- Young, Ry -- GM27099/GM/NIGMS NIH HHS/ -- GM62410/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2005 Jan 7;307(5706):113-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843-2128, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15637279" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Bacteriophage P1/*enzymology ; Binding Sites ; Catalytic Domain ; Cell Membrane/enzymology ; Chemistry, Physical ; Crystallography, X-Ray ; Cysteine/chemistry ; Enzyme Activation ; Escherichia coli/enzymology/virology ; Isomerism ; Lipid Bilayers ; Models, Molecular ; Molecular Sequence Data ; Muramidase/*chemistry/genetics/*metabolism ; Mutation ; Physicochemical Phenomena ; Protein Conformation ; Protein Sorting Signals ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Recombinant Fusion Proteins/chemistry/metabolism
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    Environmental health. Debate continues over safety of water spiked with rocket fuel (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-02-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stokstad, Erik -- New York, N.Y. -- Science. 2005 Jan 28;307(5709):507.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15681361" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/drug effects/embryology ; Female ; Humans ; Maximum Allowable Concentration ; National Academy of Sciences (U.S.) ; Perchlorates/administration & dosage/*toxicity ; Pregnancy ; Rats ; Risk Assessment ; Thyroid Gland/drug effects ; Thyroid Hormones/metabolism ; Toxicity Tests ; United States ; United States Environmental Protection Agency ; Water Pollutants, Chemical/administration & dosage/*toxicity ; *Water Supply
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    The structure of interleukin-2 complexed with its alpha receptor (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-06-04
    Description: Interleukin-2 (IL-2) is an immunoregulatory cytokine that binds sequentially to the alpha (IL-2Ralpha), beta (IL-2Rbeta), and common gamma chain (gammac) receptor subunits. Here we present the 2.8 angstrom crystal structure of a complex between human IL-2 and IL-2Ralpha, which interact in a docking mode distinct from that of other cytokine receptor complexes. IL-2Ralpha is composed of strand-swapped "sushi-like" domains, unlike the classical cytokine receptor fold. As a result of this domain swap, IL-2Ralpha uses a composite surface to dock into a groove on IL-2 that also serves as a binding site for antagonist drugs. With this complex, we now have representative structures for each class of hematopoietic cytokine receptor-docking modules.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rickert, Mathias -- Wang, Xinquan -- Boulanger, Martin J -- Goriatcheva, Natalia -- Garcia, K Christopher -- AI51321/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2005 Jun 3;308(5727):1477-80.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Departments of Microbiology and Immunology, and Structural Biology, Stanford University School of Medicine, 299 Campus Drive, Fairchild D319, Stanford, CA 94305-5124, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15933202" target="_blank"〉PubMed〈/a〉
    Keywords: Crystallography, X-Ray ; Humans ; Interleukin-2/*chemistry/metabolism ; Interleukin-2 Receptor alpha Subunit ; Models, Molecular ; Protein Binding ; Protein Conformation ; Receptors, Interleukin/*chemistry/metabolism
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    Let's talk about sex--and drugs (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-06-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Enserink, Martin -- New York, N.Y. -- Science. 2005 Jun 10;308(5728):1578.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15947172" target="_blank"〉PubMed〈/a〉
    Keywords: Clinical Trials as Topic ; Drug Approval ; Female ; Humans ; Placebo Effect ; Sexual Dysfunctions, Psychological/*drug therapy ; Testosterone/administration & dosage/adverse effects/*therapeutic use ; United States ; United States Food and Drug Administration
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    Embryonic stem cells. Moderate Republican led the winning coalition (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-06-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, Constance -- New York, N.Y. -- Science. 2005 Jun 3;308(5727):1389.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15933165" target="_blank"〉PubMed〈/a〉
    Keywords: Biomedical Research/*legislation & jurisprudence ; Embryo, Mammalian/cytology ; Federal Government ; Humans ; Politics ; *Stem Cells ; United States
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    Protecting privacy of human subjects (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-02-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Roche, Patricia A -- New York, N.Y. -- Science. 2005 Feb 25;307(5713):1200-1; author reply 1200-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15731425" target="_blank"〉PubMed〈/a〉
    Keywords: Biomedical Research/*legislation & jurisprudence ; *Genetic Privacy ; Genetic Research/*legislation & jurisprudence ; *Health Insurance Portability and Accountability Act ; Humans ; *Privacy ; United States
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    Crystal structure of human toll-like receptor 3 (TLR3) ectodomain (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-06-18
    Description: Toll-like receptors (TLRs) play key roles in activating immune responses during infection. The human TLR3 ectodomain structure at 2.1 angstroms reveals a large horseshoe-shaped solenoid assembled from 23 leucine-rich repeats (LRRs). Asparagines conserved in the 24-residue LRR motif contribute extensive hydrogen-bonding networks for solenoid stabilization. TLR3 is largely masked by carbohydrate, but one face is glycosylation-free, which suggests its potential role in ligand binding and oligomerization. Highly conserved surface residues and a TLR3-specific LRR insertion form a homodimer interface in the crystal, whereas two patches of positively charged residues and a second insertion would provide an appropriate binding site for double-stranded RNA.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Choe, Jungwoo -- Kelker, Matthew S -- Wilson, Ian A -- AI-42266/AI/NIAID NIH HHS/ -- CA-58896/CA/NCI NIH HHS/ -- T32 AI077606/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2005 Jul 22;309(5734):581-5. Epub 2005 Jun 16.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Biology and Skaggs Institute for Chemical Biology, Scripps Research Institute (TSRI), 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15961631" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Motifs ; Amino Acid Sequence ; Binding Sites ; Crystallography, X-Ray ; Dimerization ; Glycosylation ; Humans ; Hydrogen Bonding ; Leucine/chemistry ; Ligands ; Membrane Glycoproteins/*chemistry/metabolism ; Models, Molecular ; Molecular Sequence Data ; Protein Conformation ; Protein Structure, Tertiary ; RNA, Double-Stranded/metabolism ; Receptors, Cell Surface/*chemistry/metabolism ; Repetitive Sequences, Amino Acid ; Signal Transduction ; Static Electricity ; Surface Properties ; Toll-Like Receptor 3 ; Toll-Like Receptors
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    The perils of increased aquaculture (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-09-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mann, David A -- New York, N.Y. -- Science. 2005 Sep 2;309(5740):1489.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16141045" target="_blank"〉PubMed〈/a〉
    Keywords: Advisory Committees ; *Aquaculture ; Oceans and Seas ; *Public Policy ; *Seafood ; United States ; United States Government Agencies
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    Marburger makes his position clear (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-02-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marburger, John H 3rd -- New York, N.Y. -- Science. 2005 Jan 28;307(5709):515.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15681366" target="_blank"〉PubMed〈/a〉
    Keywords: *Politics ; *Research Personnel ; *Science ; United States
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    Protecting the privacy of human subjects (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-03-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Huberman, Bernardo A -- Hogg, Tad -- New York, N.Y. -- Science. 2005 Feb 25;307(5713):1200-1; author reply 1200-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15736302" target="_blank"〉PubMed〈/a〉
    Keywords: *Disclosure ; *Genetic Privacy ; *Genetic Research ; Humans ; Public Policy ; United States
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    The importance of land-cover change in simulating future climates (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-12-13
    Description: Adding the effects of changes in land cover to the A2 and B1 transient climate simulations described in the Special Report on Emissions Scenarios (SRES) by the Intergovernmental Panel on Climate Change leads to significantly different regional climates in 2100 as compared with climates resulting from atmospheric SRES forcings alone. Agricultural expansion in the A2 scenario results in significant additional warming over the Amazon and cooling of the upper air column and nearby oceans. These and other influences on the Hadley and monsoon circulations affect extratropical climates. Agricultural expansion in the mid-latitudes produces cooling and decreases in the mean daily temperature range over many areas. The A2 scenario results in more significant change, often of opposite sign, than does the B1 scenario.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Feddema, Johannes J -- Oleson, Keith W -- Bonan, Gordon B -- Mearns, Linda O -- Buja, Lawrence E -- Meehl, Gerald A -- Washington, Warren M -- New York, N.Y. -- Science. 2005 Dec 9;310(5754):1674-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Geography, University of Kansas, Lawrence, KS 66045, USA. feddema@ku.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16339443" target="_blank"〉PubMed〈/a〉
    Keywords: Africa ; *Agriculture ; Asia ; *Atmosphere ; Australia ; *Climate ; Computer Simulation ; Forecasting ; Humans ; Oceans and Seas ; South America ; Temperature ; Trees ; Tropical Climate ; United States ; Weather
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    Responsibility beyond 60 years (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-09-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bennett, Burton G -- New York, N.Y. -- Science. 2005 Sep 9;309(5741):1649.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16150979" target="_blank"〉PubMed〈/a〉
    Keywords: Aging ; Cohort Studies ; Female ; Humans ; International Cooperation ; Japan/epidemiology ; Male ; Neoplasms, Radiation-Induced/epidemiology/mortality ; *Nuclear Warfare ; Radiation Dosage ; *Radiation Effects ; Radiation Injuries/*epidemiology/mortality ; Radiation Protection ; United States ; World War II
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    Clinical trials: keeping score on the sexes (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-06-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, Eliot -- New York, N.Y. -- Science. 2005 Jun 10;308(5728):1571.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15947168" target="_blank"〉PubMed〈/a〉
    Keywords: *Clinical Trials as Topic ; Female ; Humans ; Male ; National Institutes of Health (U.S.) ; Patient Selection ; Research Design ; *Sex Characteristics ; United States ; *Women ; Women's Health
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    The problem of child sexual abuse (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-08-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fink, Paul -- New York, N.Y. -- Science. 2005 Aug 19;309(5738):1182-5; author reply 1182-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16109864" target="_blank"〉PubMed〈/a〉
    Keywords: Child ; *Child Abuse, Sexual/economics/prevention & control/statistics & numerical data ; *Child Welfare ; Female ; Humans ; Male ; Mental Disorders/etiology ; Risk Factors ; United States
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    Intellectual property. U.S. patent reform begins long journey through Congress (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-06-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kintisch, Eli -- New York, N.Y. -- Science. 2005 Jun 17;308(5729):1725-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15961638" target="_blank"〉PubMed〈/a〉
    Keywords: Biotechnology ; Drug Industry ; Intellectual Property ; Patents as Topic/*legislation & jurisprudence ; Software ; Technology ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Bioethics. Anticloning forces launch second-term offensive (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-03-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kintisch, Eli -- New York, N.Y. -- Science. 2005 Mar 18;307(5716):1702-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15774727" target="_blank"〉PubMed〈/a〉
    Keywords: Cloning, Organism/ethics/*legislation & jurisprudence ; Humans ; Politics ; Research Embryo Creation/ethics/*legislation & jurisprudence ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    AIDS clinical trials. More woes for novel HIV prevention approach (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-03-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, Jon -- New York, N.Y. -- Science. 2005 Mar 18;307(5716):1708.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15774734" target="_blank"〉PubMed〈/a〉
    Keywords: Adenine/*analogs & derivatives/*therapeutic use ; Anti-HIV Agents/*therapeutic use ; Centers for Disease Control and Prevention (U.S.) ; *Clinical Trials as Topic/ethics/standards ; HIV Infections/*prevention & control ; Humans ; Nigeria ; Organophosphonates/*therapeutic use ; Patient Selection ; Prostitution ; Substance Abuse, Intravenous ; Tenofovir ; Thailand ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 80
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    Scientific publishing. Society bars papers from Iranian authors (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-06-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bhattacharjee, Yudhijit -- New York, N.Y. -- Science. 2005 Jun 17;308(5729):1722-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15961635" target="_blank"〉PubMed〈/a〉
    Keywords: Authorship ; *Aviation ; Commerce ; *Editorial Policies ; Engineering ; International Cooperation ; Iran ; Publishing ; Security Measures ; *Societies, Scientific ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 81
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    Career transitions. Panel throws lifeline to bio postdocs (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-03-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bhattacharjee, Yudhijit -- New York, N.Y. -- Science. 2005 Mar 25;307(5717):1849.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15790812" target="_blank"〉PubMed〈/a〉
    Keywords: *Biomedical Research/economics ; *Career Mobility ; *Education, Graduate ; Financing, Government ; Foreign Professional Personnel ; National Institutes of Health (U.S.)/*economics ; *Research Personnel/economics ; *Research Support as Topic ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    U.S. immigration policy. New rules ease scientific exchanges (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-02-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bhattacharjee, Yudhijit -- New York, N.Y. -- Science. 2005 Feb 18;307(5712):1023.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15718434" target="_blank"〉PubMed〈/a〉
    Keywords: *Emigration and Immigration ; *Foreign Professional Personnel ; Security Measures ; *Students ; *Travel ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 83
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    Psychology. The science of child sexual abuse (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-04-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Freyd, Jennifer J -- Putnam, Frank W -- Lyon, Thomas D -- Becker-Blease, Kathryn A -- Cheit, Ross E -- Siegel, Nancy B -- Pezdek, Kathy -- R01 HD047290/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 2005 Apr 22;308(5721):501.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychology, University of Oregon, Eugene, OR, 97403-1227, USA. jjf@dynamic. uoregon.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15845837" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Child ; *Child Abuse, Sexual/economics/prevention & control/psychology/statistics & ; numerical data ; Cost-Benefit Analysis ; Education ; Education, Medical ; Education, Professional ; Humans ; Interdisciplinary Communication ; Memory ; Mental Health Services ; Public Policy ; *Research ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Ecology. Are U.S. coral reefs on the slippery slope to slime? (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-03-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pandolfi, J M -- Jackson, J B C -- Baron, N -- Bradbury, R H -- Guzman, H M -- Hughes, T P -- Kappel, C V -- Micheli, F -- Ogden, J C -- Possingham, H P -- Sala, E -- New York, N.Y. -- Science. 2005 Mar 18;307(5716):1725-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Centre for Marine Studies and Department of Earth Sciences, University of Queensland, St. Lucia, QLD 4072, Australia. j.pandolfi@uq.edu.au〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15774744" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Anthozoa ; Biodiversity ; Biomass ; Conservation of Natural Resources ; *Ecosystem ; Eutrophication ; Fishes ; Food Chain ; Greenhouse Effect ; International Cooperation ; Public Policy ; United States ; Water Pollution
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Drug regulation. Plan B: A collision of science and politics (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-10-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin, Jennifer -- New York, N.Y. -- Science. 2005 Oct 7;310(5745):38-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16210512" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Advisory Committees ; *Contraceptives, Postcoital/adverse effects ; *Drug Approval ; Female ; Humans ; *Levonorgestrel/adverse effects ; *Nonprescription Drugs/adverse effects ; Politics ; Sexual Behavior ; United States ; *United States Food and Drug Administration
    Print ISSN: 0036-8075
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    Epidemiology. DNA identifications after the 9/11 World Trade Center attack (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-11-19
    Description: The attack on the World Trade Center on 9/11/2001 challenged current approaches to forensic DNA typing methods. The large number of victims and the extreme thermal and physical conditions of the site necessitated special approaches to the DNA-based identification. Because of these and many additional challenges, new procedures were created or modified from routine forensic protocols. This effort facilitated the identification of 1594 of the 2749 victims. In this Policy Forum, the authors, who were were members of the World Trade Center Kinship and Data Analysis Panel, review the lessons of the attack response from the perspective of DNA forensic identification and suggest policies and procedures for future mass disasters or large-scale terrorist attacks.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Biesecker, Leslie G -- Bailey-Wilson, Joan E -- Ballantyne, Jack -- Baum, Howard -- Bieber, Frederick R -- Brenner, Charles -- Budowle, Bruce -- Butler, John M -- Carmody, George -- Conneally, P Michael -- Duceman, Barry -- Eisenberg, Arthur -- Forman, Lisa -- Kidd, Kenneth K -- Leclair, Benoit -- Niezgoda, Steven -- Parsons, Thomas J -- Pugh, Elizabeth -- Shaler, Robert -- Sherry, Stephen T -- Sozer, Amanda -- Walsh, Anne -- New York, N.Y. -- Science. 2005 Nov 18;310(5751):1122-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16293742" target="_blank"〉PubMed〈/a〉
    Keywords: Dna ; *DNA Fingerprinting/methods ; DNA, Mitochondrial ; Disaster Planning ; Family ; Female ; Forecasting ; Genetic Markers ; Humans ; Male ; *September 11 Terrorist Attacks ; Specimen Handling ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Plant sciences. Recognition at a distance (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-04-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schulze-Lefert, Paul -- Bieri, Stephane -- New York, N.Y. -- Science. 2005 Apr 22;308(5721):506-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Plant Microbe Interactions, Max-Planck-Institut fur Zuchtungsforschung, D-50829 Koln, Germany. schlef@mpiz-koeln.mpg.de〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15845841" target="_blank"〉PubMed〈/a〉
    Keywords: Arabidopsis/*immunology/metabolism/microbiology ; Arabidopsis Proteins/metabolism ; Bacterial Proteins/chemistry/genetics/*metabolism ; Carrier Proteins/metabolism ; Cladosporium/immunology/metabolism ; Cyclophilins/metabolism ; Fungal Proteins/*metabolism ; Leucine ; Lycopersicon esculentum/*immunology/metabolism/microbiology ; Models, Immunological ; Mutation ; Peptide Hydrolases/genetics/metabolism ; Plant Diseases ; Plant Proteins/chemistry/genetics/*metabolism ; Protein Conformation ; Pseudomonas syringae/immunology/metabolism ; Recombinant Proteins/metabolism ; Repetitive Sequences, Amino Acid
    Print ISSN: 0036-8075
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    Foundations. Joining forces for brain tumor research (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-07-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin, Jennifer -- New York, N.Y. -- Science. 2005 Jul 1;309(5731):32.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15994495" target="_blank"〉PubMed〈/a〉
    Keywords: *Biomedical Research ; *Brain Neoplasms ; Canada ; *Foundations ; Humans ; *Research Support as Topic ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 89
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    Structures of the bacterial ribosome at 3.5 A resolution (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-11-08
    Description: We describe two structures of the intact bacterial ribosome from Escherichia coli determined to a resolution of 3.5 angstroms by x-ray crystallography. These structures provide a detailed view of the interface between the small and large ribosomal subunits and the conformation of the peptidyl transferase center in the context of the intact ribosome. Differences between the two ribosomes reveal a high degree of flexibility between the head and the rest of the small subunit. Swiveling of the head of the small subunit observed in the present structures, coupled to the ratchet-like motion of the two subunits observed previously, suggests a mechanism for the final movements of messenger RNA (mRNA) and transfer RNAs (tRNAs) during translocation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schuwirth, Barbara S -- Borovinskaya, Maria A -- Hau, Cathy W -- Zhang, Wen -- Vila-Sanjurjo, Anton -- Holton, James M -- Cate, Jamie H Doudna -- CA92584/CA/NCI NIH HHS/ -- GM65050/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2005 Nov 4;310(5749):827-34.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry, University of California, Berkeley, CA 94720, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16272117" target="_blank"〉PubMed〈/a〉
    Keywords: Binding Sites ; Crystallization ; Crystallography, X-Ray ; Escherichia coli/*chemistry/*ultrastructure ; Escherichia coli Proteins/biosynthesis/chemistry ; Hydrogen Bonding ; Magnesium/metabolism ; Models, Molecular ; Nucleic Acid Conformation ; Peptidyl Transferases/chemistry ; Protein Biosynthesis ; Protein Conformation ; RNA, Bacterial/chemistry/metabolism ; RNA, Messenger/chemistry/metabolism ; RNA, Ribosomal/*chemistry ; RNA, Transfer/chemistry/metabolism ; Ribosomal Proteins/*chemistry ; Ribosomes/*chemistry/*ultrastructure
    Print ISSN: 0036-8075
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    PLOS position on NIH public access policy (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-04-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gass, Andy -- Doyle, Helen -- New York, N.Y. -- Science. 2005 Apr 15;308(5720):356.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15831740" target="_blank"〉PubMed〈/a〉
    Keywords: Access to Information ; *Biomedical Research ; *Information Dissemination ; Information Storage and Retrieval ; Internet ; *National Institutes of Health (U.S.) ; National Library of Medicine (U.S.) ; Periodicals as Topic ; *Publishing ; Research Support as Topic ; United States
    Print ISSN: 0036-8075
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    Drug development. Lupus drug company asks FDA for second chance (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-02-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin, Jennifer -- New York, N.Y. -- Science. 2005 Feb 11;307(5711):835.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15705822" target="_blank"〉PubMed〈/a〉
    Keywords: Antibodies, Antinuclear/analysis/blood/immunology ; Antibody Affinity ; Clinical Trials, Phase III as Topic ; Clinical Trials, Phase IV as Topic ; *Drug Approval ; Drug Industry ; Humans ; Lupus Erythematosus, Systemic/*drug therapy ; Lupus Nephritis/*drug therapy ; Oligonucleotides/adverse effects/*therapeutic use ; United States ; *United States Food and Drug Administration
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    U.S. science budget. VA asked to bolster mental health research (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-06-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin, Jennifer -- New York, N.Y. -- Science. 2005 Jun 10;308(5728):1526-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15947142" target="_blank"〉PubMed〈/a〉
    Keywords: *Biomedical Research/economics ; Budgets ; Humans ; *Mental Health ; *Research Support as Topic ; United States ; United States Department of Veterans Affairs/*economics ; *Veterans
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    Presidential address. The nexus: where science meets society (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-12-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jackson, Shirley Ann -- New York, N.Y. -- Science. 2005 Dec 9;310(5754):1634-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Rensselaer Polytechnic Institute, Troy, NY, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16353298" target="_blank"〉PubMed〈/a〉
    Keywords: Communications Media ; Culture ; Engineering/education/manpower/trends ; Government ; Humans ; Internationality ; *Public Policy ; *Research/manpower/trends ; *Science/education/ethics/manpower/trends ; Security Measures ; Social Values ; *Sociology ; United States
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    Computational thermostabilization of an enzyme (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-05-10
    Description: Thermostabilizing an enzyme while maintaining its activity for industrial or biomedical applications can be difficult with traditional selection methods. We describe a rapid computational approach that identified three mutations within a model enzyme that produced a 10 degrees C increase in apparent melting temperature T(m) and a 30-fold increase in half-life at 50 degrees C, with no reduction in catalytic efficiency. The effects of the mutations were synergistic, giving an increase in excess of the sum of their individual effects. The redesigned enzyme induced an increased, temperature-dependent bacterial growth rate under conditions that required its activity, thereby coupling molecular and metabolic engineering.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3412875/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3412875/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Korkegian, Aaron -- Black, Margaret E -- Baker, David -- Stoddard, Barry L -- CA85939/CA/NCI NIH HHS/ -- CA97328/CA/NCI NIH HHS/ -- GM49857/GM/NIGMS NIH HHS/ -- GM59224/GM/NIGMS NIH HHS/ -- R01 CA097328/CA/NCI NIH HHS/ -- R01 GM049857/GM/NIGMS NIH HHS/ -- T32-GM08268/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2005 May 6;308(5723):857-60.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Basic Sciences, Fred Hutchinson Cancer Research Center (FHCRC), 1100 Fairview Avenue North, Seattle, WA 98109, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15879217" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Binding Sites ; Catalysis ; Circular Dichroism ; *Computer Simulation ; Crystallography, X-Ray ; Cytosine Deaminase/*chemistry/*metabolism ; Enzyme Stability ; Escherichia coli/genetics/metabolism ; Kinetics ; Models, Molecular ; Molecular Sequence Data ; Monte Carlo Method ; Mutagenesis, Site-Directed ; Point Mutation ; Protein Conformation ; Protein Denaturation ; *Protein Engineering ; Protein Folding ; Protein Structure, Secondary ; Software ; Temperature ; Thermodynamics ; Transformation, Genetic ; Yeasts/enzymology
    Print ISSN: 0036-8075
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    U.S. workforce. A glass ceiling for Asian scientists? (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-10-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- New York, N.Y. -- Science. 2005 Oct 28;310(5748):606-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16254160" target="_blank"〉PubMed〈/a〉
    Keywords: *Asian Americans ; *Career Mobility ; Humans ; *National Institutes of Health (U.S.)/organization & administration/statistics & ; numerical data ; Science/*manpower ; United States
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    U.S. public sector. Agency kills new performance rules (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-04-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- New York, N.Y. -- Science. 2005 Apr 29;308(5722):617.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15860601" target="_blank"〉PubMed〈/a〉
    Keywords: *Ecosystem ; Employee Performance Appraisal/*economics ; *Environment ; United States ; *United States Government Agencies
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 97
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    Gene therapy. As Gelsinger case ends, gene therapy suffers another blow (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-02-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin, Jennifer -- Kaiser, Jocelyn -- New York, N.Y. -- Science. 2005 Feb 18;307(5712):1028.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15718439" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Advisory Committees ; *Clinical Trials as Topic ; France ; Genetic Diseases, X-Linked/*therapy ; Genetic Therapy/*adverse effects/*legislation & jurisprudence ; Humans ; Infant ; Jurisprudence ; Leukemia/etiology ; Male ; National Institutes of Health (U.S.) ; Severe Combined Immunodeficiency/*therapy ; United States ; United States Food and Drug Administration
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 98
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    Structural observation of the primary isomerization in vision with femtosecond-stimulated Raman (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-11-15
    Description: The primary event that initiates vision is the light-induced 11-cis to all-trans isomerization of retinal in the visual pigment rhodopsin. Despite decades of study with the traditional tools of chemical reaction dynamics, both the timing and nature of the atomic motions that lead to photoproduct production remain unknown. We used femtosecond-stimulated Raman spectroscopy to obtain time-resolved vibrational spectra of the molecular structures formed along the reaction coordinate. The spectral evolution of the vibrational features from 200 femtoseconds to 1 picosecond after photon absorption reveals the temporal sequencing of the geometric changes in the retinal backbone that activate this receptor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kukura, Philipp -- McCamant, David W -- Yoon, Sangwoon -- Wandschneider, Daniel B -- Mathies, Richard A -- EY-02051/EY/NEI NIH HHS/ -- New York, N.Y. -- Science. 2005 Nov 11;310(5750):1006-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry, University of California, Berkeley, CA 94720, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16284176" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cattle ; Chemistry, Physical ; Energy Transfer ; Hydrogen/chemistry ; Isomerism ; *Light ; Models, Chemical ; Models, Molecular ; Photochemistry ; Photons ; Physicochemical Phenomena ; Protein Conformation ; Retinaldehyde/*chemistry ; Rhodopsin/*chemistry ; Spectrum Analysis, Raman ; Time Factors ; *Vision, Ocular
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 99
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    Scientific publishing. NIEHS journal is on the block (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-12-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2005 Dec 2;310(5753):1407.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16322429" target="_blank"〉PubMed〈/a〉
    Keywords: Commerce ; Contract Services ; *Environmental Health ; *National Institutes of Health (U.S.)/economics/organization & administration ; *Periodicals as Topic ; *Publishing ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 100
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    Genomic medicine. Gene sequence study takes a stab at personalized medicine (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-05-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pennisi, Elizabeth -- New York, N.Y. -- Science. 2005 May 20;308(5725):1102.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15905375" target="_blank"〉PubMed〈/a〉
    Keywords: Genetic Counseling ; *Genetic Predisposition to Disease ; Genetic Testing ; *Genetics, Medical ; *Genome, Human ; Human Genome Project ; Humans ; National Institutes of Health (U.S.) ; Pilot Projects ; Risk Factors ; *Sequence Analysis, DNA ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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