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  • Mice  (214)
  • Analytical Chemistry and Spectroscopy
  • Cell & Developmental Biology
  • 2010-2014
  • 2000-2004  (214)
  • 1950-1954
  • 1945-1949
  • 1940-1944
  • 2001  (214)
  • 1
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    Neuroscience. An antibiotic to treat Alzheimer's? (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-02-24
    Description: An antibiotic once used to treat traveler's diarrhea might battle Alzheimer's disease as well, researchers announced here last week at the Society for Neuroscience's annual meeting. The drug dissolves Alzheimer's-like plaques in mouse brains, apparently by trapping the copper and zinc that stud these deposits. A clinical trial to test whether the drug helps people with Alzheimer's is already under way.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Helmuth, L -- New York, N.Y. -- Science. 2000 Nov 17;290(5495):1273-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11185394" target="_blank"〉PubMed〈/a〉
    Keywords: Alzheimer Disease/*drug therapy/metabolism/pathology ; Amyloid beta-Peptides/*metabolism ; Animals ; Brain/drug effects/metabolism/pathology ; Clinical Trials, Phase II as Topic ; Clioquinol/metabolism/pharmacology/*therapeutic use ; Copper/metabolism/pharmacology ; Humans ; Mice ; Plaque, Amyloid/*drug effects/metabolism ; Zinc/metabolism/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Genomics and gene therapy. Artificial chromosomes coming to life (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-02-24
    Description: One of the biggest obstacles to gene therapy is the delivery of the therapeutic gene to the target tissue so that it is appropriately expressed. In his Perspective, Willard looks at the potential advantages of using a human artificial chromosome to maintain expression of a therapeutic gene and discusses some of the hurdles yet to be overcome before this gene delivery system can be tried out in the clinic.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Willard, H F -- New York, N.Y. -- Science. 2000 Nov 17;290(5495):1308-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Genetics and Center for Human Genetics at Case Western Reserve University and the Research Institute of Universi Hospitals of Cleveland, Cleveland, OH 44106, USA. hfw@po.CWRU.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11185406" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Centromere/chemistry/genetics/physiology ; *Chromosomes, Artificial, Human/genetics/physiology/ultrastructure ; Chromosomes, Artificial, Mammalian ; DNA, Satellite/genetics ; Gene Expression ; Gene Transfer Techniques ; *Genetic Therapy ; Genetic Vectors ; Humans ; Mice
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Neurobiology. A stargazer foretells the way to the synapse (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-02-24
    Description: How do AMPA receptors that are made in the cytoplasm of excitatory neurons travel to and become localized in the distant postsynaptic membranes of dendrites? Nakagawa and Sheng, in a Perspective, suggest that the answer may lie in the stargazin protein that has now been found to interact with AMPA receptors, guiding them to the postsynaptic membrane.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nakagawa, T -- Sheng, M -- New York, N.Y. -- Science. 2000 Dec 22;290(5500):2270-1.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurobiology, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11188726" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Calcium Channels/chemistry/genetics/*metabolism ; Cell Membrane/metabolism ; Cerebellum/cytology/*metabolism ; Dendrites/metabolism ; Mice ; Mice, Mutant Strains ; Models, Biological ; Nerve Tissue Proteins/metabolism ; Neurons/*metabolism ; Protein Binding ; Protein Transport ; Receptors, AMPA/*metabolism ; Synapses/metabolism ; Synaptic Membranes/*metabolism ; Synaptic Transmission
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Development. Survival is impossible without an editor (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-02-24
    Description: RNA editing is a fascinating phenomenon that is found in both animal and plant cells. By converting an adenosine base to an inosine (which behaves like guanosine) in RNA that has already been transcribed, certain RNA sequences (and hence the amino acids they encode) are altered. In a Perspective, Keegan, Gallo and O'Connell explore new results showing that activity of the editing enzyme ADAR1 is crucial for normal development of red blood cells in mouse embryos.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Keegan, L P -- Gallo, A -- O'Connell, M A -- New York, N.Y. -- Science. 2000 Dec 1;290(5497):1707-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉MRC Human Genetics Unit, Western General Hospital, Edinburgh EH4 2XU, UK. liam.keegan@hgu.mrc.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11186391" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine/metabolism ; Adenosine Deaminase/chemistry/*genetics/*metabolism ; Animals ; Base Pairing ; Central Nervous System/metabolism ; Chimera ; Drosophila/genetics/metabolism ; Embryo, Mammalian/cytology ; Embryo, Nonmammalian ; *Erythropoiesis ; Gene Dosage ; Hematopoietic Stem Cells/cytology/enzymology ; Inosine/metabolism ; Liver/metabolism ; Mice ; Mutation ; Phenotype ; Protein Structure, Tertiary ; *RNA Editing ; RNA Precursors/metabolism ; RNA, Double-Stranded/metabolism ; RNA-Binding Proteins ; Receptors, AMPA/genetics ; Stem Cells/cytology/enzymology ; Teratoma/genetics/pathology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Translational roots for mental retardation? (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-02-24
    Description: A flurry of findings points to protein translation in the dendrites of neurons as a key feature leading to the changes at synapses that are vital to learning (see main text). And one recent discovery suggests that when this translation goes awry, it can lead to mental retardation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Barinaga, M -- New York, N.Y. -- Science. 2000 Oct 27;290(5492):737.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11184206" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Dendrites/*metabolism ; Fragile X Mental Retardation Protein ; Fragile X Syndrome/etiology/genetics/metabolism ; Humans ; Intellectual Disability/*etiology/genetics/metabolism ; Mice ; Mutation ; Nerve Tissue Proteins/*genetics/metabolism ; *Protein Biosynthesis ; *RNA-Binding Proteins ; Synapses/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    Research misconduct. Texas scientist admits falsifying results (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-02-24
    Description: A University of Texas (UT) immunologist has admitted to federal officials that he falsified research results over at least a 5-year period, leaving a trail of retracted papers and disgruntled collaborators. The scientist, who resigned and has been barred from receiving federal research grants, was found to have repeatedly duped colleagues by spiking test tubes with doses of a radioactive marker that produced positive results, according to detailed reports by UT and federal investigators.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Malakoff, D -- New York, N.Y. -- Science. 2000 Oct 13;290(5490):245-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11183367" target="_blank"〉PubMed〈/a〉
    Keywords: *Allergy and Immunology ; Animals ; HLA-B27 Antigen/genetics ; Mice ; Research/*standards ; *Scientific Misconduct ; Texas ; United States ; United States Office of Research Integrity ; Universities
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    Laboratory animals. Researchers fight plan to regulate mice, birds (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-02-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Malakoff, D -- New York, N.Y. -- Science. 2000 Oct 6;290(5489):23.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11183138" target="_blank"〉PubMed〈/a〉
    Keywords: Animal Testing Alternatives/*legislation & jurisprudence ; Animal Welfare/*legislation & jurisprudence ; Animals ; *Animals, Laboratory ; Birds ; Mice ; Rats ; United States ; United States Department of Agriculture/*legislation & jurisprudence
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    Circadian rhythms. A time to rest: clock signal identified (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-12-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Barinaga, M -- New York, N.Y. -- Science. 2001 Dec 21;294(5551):2453.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11752547" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Clocks/physiology ; Circadian Rhythm/drug effects/*physiology ; Cricetinae ; Darkness ; Hypothalamus/*metabolism ; Light ; Mice ; *Motor Activity/drug effects ; Mutation ; Neurons/*metabolism ; Receptor, Epidermal Growth Factor/genetics/*metabolism ; Retinal Ganglion Cells/metabolism ; Signal Transduction ; Suprachiasmatic Nucleus/*metabolism ; Transforming Growth Factor alpha/*metabolism/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    Olfaction. Smell's course is predetermined (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-11-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Barinaga, M -- New York, N.Y. -- Science. 2001 Nov 9;294(5545):1269-71.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11701909" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain Mapping ; Drosophila ; Mice ; Neurons/*physiology ; Odors ; Olfactory Bulb/metabolism ; Olfactory Pathways/cytology/*physiology ; Olfactory Receptor Neurons/metabolism/*physiology ; Receptors, Odorant/genetics/metabolism ; Smell/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    Publication rights for sequence data producers (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-02-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bell, E -- New York, N.Y. -- Science. 2000 Dec 1;290(5497):1696-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11186390" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Base Sequence ; Databases, Factual ; *Genome ; Guidelines as Topic ; Humans ; Major Histocompatibility Complex/*genetics ; Mice ; Peer Review, Research ; *Publishing
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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