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  • Articles  (17,774)
  • Springer  (12,322)
  • American Association for the Advancement of Science  (4,329)
  • American Meteorological Society  (1,123)
  • 1995-1999  (17,774)
  • 1990-1994
  • 1999  (17,774)
  • Medicine  (11,400)
  • Geosciences  (6,409)
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  • Articles  (17,774)
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  • 1995-1999  (17,774)
  • 1990-1994
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  • 1
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    GPS solutions 2 (1999), S. 1-2 
    ISSN: 1521-1886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Architecture, Civil Engineering, Surveying , Geosciences
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  • 2
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    GPS solutions 2 (1999), S. 24-36 
    ISSN: 1521-1886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Architecture, Civil Engineering, Surveying , Geosciences
    Notes: The purpose of this article is to report on an integrated system that uses GPS and other low cost sensors for azimuth and pitch determination. The ability of the integrated system to maintain a solution over periods of induced GPS outage is also demonstrated. © 1999 John Wiley & Sons, Inc.
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  • 3
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    GPS solutions 2 (1999), S. 18-23 
    ISSN: 1521-1886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Architecture, Civil Engineering, Surveying , Geosciences
    Notes: The Global Positioning System (GPS) satellita navigation aiding system, sometimes called NAVSTAR, has become a utility to the military and many civilian areas. GPS, currently consisting of 24 satellites, is used by the military for navigation, precision weapons delivery, and the future digital battlefield. In the civilian sector, GPS is widely used as the primary or secondary aid for land, water, and air navigation; as a surveying aid; as a vehicle location system; and as a precision time standard for cellular and ATM sites. In the aviation community, GPS is becoming an integral part of the WAAS (Wide Area Augmentation System) and the LAAS (Local Area Augmentation System) for en route navigation in North America and Category II and III precision approach, and for surface navigation. The vulnerability of GPS have become the vulnerabilities of WAAS and LAAS, and require consideration of interference mittigation techniques. © 1999 John Wiley & Sons, Inc.
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  • 4
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    GPS solutions 2 (1999), S. 37-40 
    ISSN: 1521-1886
    Source: Springer Online Journal Archives 1860-2000
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  • 5
    ISSN: 1521-1886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Architecture, Civil Engineering, Surveying , Geosciences
    Notes: The growing importance and effectiveness of the Global Positioning System (GPS) in positioning geophysical surveys is now well established. In Ecuador's Amazon basin the use of GPS was the determining factor in the successful completion of a gravity survey carried out in 1994. Over 500 gravity stations, spaced from 1 to 5 km apart and positioned by GPS, were collected in the jungle environment in the country's southeast, where the preexisting data, of variable and unknown quality, were mostly confined to areas along the major rivers. This station densification, which includes the reoccupation of selected points, contributed to increase the gravity coverage; it also allowed us to evaluate and correct 1100 preexisting data points in the area, so that the different surveys can be merged. The composite data set is used for a geologic analysis of the study area, where previously unknown structures are discovered. © 1999 John Wiley & Sons, Inc.
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  • 6
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    GPS solutions 2 (1999), S. 41-49 
    ISSN: 1521-1886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Architecture, Civil Engineering, Surveying , Geosciences
    Notes: The permanent GPS tracking site at Annapolis, MD shows a 7-mm seasonal signal primarily in its horizontal position. It is suggested that thermal expansion of the pier on which the antenna rests is the source of this motion. A simple numerical model of the pier reproduces the observed motion of the GPS antenna, lending credence to this hypothesis. Although adding an additional level of complexity, this motion is predictable and the site retains it s value for high precision monitoring. Although the arrangement of this GPS site it somewhat uncommon, these results emphasize the importance of the underlying antenna monumentation when measuring crustal motions. © 1999 John Wiley & Sons, Inc.
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  • 7
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    GPS solutions 2 (1999), S. 63-69 
    ISSN: 1521-1886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Architecture, Civil Engineering, Surveying , Geosciences
    Notes: GPS ambiguity resolution is the process of resolving the unknown cycle ambiguities of double-difference (DD) carrier-phase data as integers. It is the key to fast and high-precision relative GPS positioning. Critical in the application of ambiguity resolution is its reliability. Unsuccessful ambiguity resolution, when passed unnoticed, will too often lead to unacceptable errors in the positioning results. High success rates are required for ambiguity resolution to be reliable. In this contribution we will introduce and evaluate such diagnostic measures. They complement existing methods of ambiguity resolution and allow the user and/or analyst to infer their reliability. © 1999 John Wiley & Sons, Inc.
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  • 8
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    GPS solutions 2 (1999), S. 50-62 
    ISSN: 1521-1886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Architecture, Civil Engineering, Surveying , Geosciences
    Notes: The largest error in currently used GPS orbit models is due to the effect of solar radiation pressure. Over the last few years many improvements were made in modeling the orbits of GPS satellites within the International GPS Service (IGS). Howeer, most improvements were achieved by increasing the number of estimated orbit and/or solar radiation pressure parameters. This increase in the number of estimated satellite parameters weakens the solutions of all estimated parameters (not only orbit parameters). Because of correlations the additional orbit parameters may introduce biases in other estimated quantities, for example the length of day. We present a recently developed solar radiation pressure model for the GPS satellites. This model is based on experiences and results gained at the Center for Orbit Determination in Europe (CODE) in the context of its IGS activities since June 1992. The performance of the new model is almost an order of magnitude better than that of the existing ROCK models. It also allows a reduction of the number of orbit parameters that have to be estimated. © 1999 John Wiley & Sons, Inc.
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  • 9
    ISSN: 1521-1886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Architecture, Civil Engineering, Surveying , Geosciences
    Notes: A solar-powered GPS receiver has been installed near Beaver Lake, Antarctica, to monitor postglacial isostatic rebound that may be occurring as a result of ice thinning near the Lambert Glacier since the last glacial maximum. The equipment is 400 km from the nearest Australian Antarctic base and is completely automated. It is expected that there will be sufficient solar power to operate the equipment from January 1998 to May 1998, but the data will not be recovered until the following summer season. The scatter in height computed from the first 25 days of data is ± 7.5 mm. If such precision is representative of the accuracy of the height estimates, isostatic rebound of 〈 1 mm/yr will be able to be detected after a few years of observations at the site. © 1999 John Wiley & Sons, Inc.
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  • 10
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    GPS solutions 2 (1999), S. 79-80 
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  • 11
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    GPS solutions 2 (1999), S. 81-83 
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  • 12
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    GPS solutions 2 (1999), S. 76-78 
    ISSN: 1521-1886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Architecture, Civil Engineering, Surveying , Geosciences
    Notes: Automatic analysis of geodetic-quality GPS data is available with the use of e-mail and ftp (file transfer program) as an interface to a computer at the Jet Propulsion Laboratory (JPL), where precise transmitter parameters – GPS ephemerides and clock errors – are computed regularly. The interface is such that e-mail from an external user causes the JPL computer to fetch the user's data. The computer than analyzes the data, and places the results in an area accessible to the user. An e-mail to the user gives information on the location of the analysis results, which the user can subsequently fetch. Operations on the JPL computer are entirely automatic, and require essentially no labor. © 1999 John Wiley & Sons, Inc.
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  • 13
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    GPS solutions 2 (1999), S. 1-6 
    ISSN: 1521-1886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Architecture, Civil Engineering, Surveying , Geosciences
    Notes: This article describes the Nationwide Differential Global Positioning System (NDGPS) service being developed in the United States and the enormous benefits to federal agencies, state governments, and the general public. © 1999 John Wiley & Sons, Inc.
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  • 14
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    GPS solutions 2 (1999), S. 35-43 
    ISSN: 1521-1886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Architecture, Civil Engineering, Surveying , Geosciences
    Notes: The noise term of GPS phase data can be calculated from the measured carrier-to-noise power density ratios (C/N0). The C/N0 values are used in the proposed SIGMA-ɛ model to calculate the variance matrix of double-differenced GPS phase data. Examples show the capability of this model to yield higher accuracies for GPS surveys than the use of the standard weighting scheme. Most importantly, the SIGMA-ɛ model allows the use of noisier phase data from very low elevation satellites to overcome poor satellite geometry problems. © 1999 John Wiley & Sons, Inc.
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  • 15
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    GPS solutions 2 (1999), S. 44-51 
    ISSN: 1521-1886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Architecture, Civil Engineering, Surveying , Geosciences
    Notes: Investigations of deformation styles in Asia have already led to new kinematic models that predict the spatial and temporal evolution of deformations in the region. Testing these models is now within realm of current GPS technology. In this study, GPS data during 4 months from six stations in Asia, including a new station from Hong Kong whose data were not in public domain, were analyzed for generating kinematic geophysical constraints for the deformations at the regional scale. Processing of 4 months' continuous GPS data from all stations shows small relative station velocities (Wuhan, Shanghai, Xian, and Hong Kong stations in China), except the Lhasa station, which has a northeasterly velocity of about 3 cm/year with respect to the fixed GPS station operating in Taiwan. © 1999 John Wiley & Sons, Inc.
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  • 16
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    GPS solutions 2 (1999), S. 7-21 
    ISSN: 1521-1886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Architecture, Civil Engineering, Surveying , Geosciences
    Notes: Accurate estimates of the velocity and acceleration of a platform are often needed in high dynamic positioning, airborne gravimetry, and geophysics. In turn, differentiation of GPS signals is a crucial process for obtaining these estimates. It is important in the measurement domain where, for example, the phase measurements are used along with their instantaneous derivative (Doppler) to estimate position and velocity. It is also important in postprocessing, where acceleration is usually estimated by differentiating estimates of position and velocity. Various methods of differentiating a signal can have very different effects on the resulting derivative, and their suitability varies from situation to situation. These comments set the stage for the investigations in this article. The objective is twofold: (1) to carry out a comprehensive study of possible differentiation methods, characterizing each in the frequency domain; and (2) to use real data to demonstrate each of these methods in both of the measurement and position domains, in conditions of variable, high, or unknown dynamics. Examples are given using real GPS data in both the measurement domain and in the position and velocity domain. The appropriate differentiator is used in several cases of varying dynamics to derive a Doppler signal from carrier phase measurements (rather than using the raw Doppler generated by the receiver). In the statistic case, it is seen that the accuracy of velocity estimates can be improved from 4.0 mm/s to 0.7 mm/s by using the correct filter. In conditions of medium dynamics experienced in an airborne gravity survey, it is demonstrated that accelerations as the 2–4 mGal level (1 mGal = 0.00001 m/s2) can be obtained at the required filtering periods. Finally, a precision motion table is used to show that when using the correct filter, velocity estimates under high dynamics can be improved by an order of magnitude to 27.0 mm/s. © 1999 John Wiley & Sons, Inc.
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  • 17
    ISSN: 1521-1886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Architecture, Civil Engineering, Surveying , Geosciences
    Notes: LandStar is a differential global positioning service (DGPS) that provides 24-h real-time positioning for various applications on land, water, and air in North America, Australia, New Zealand, Europe, and Africa. Its focus is on real-time applications requiring a submeter positioning capability such as agriculture, forestry, Geospatial Information Systems (GIS), survey/mapping, and land/vehicular navigation. LandStar uses a Wide Area Network of reference stations to derive DGPS corrections to model the variation of GPS error sources over a large area. These model parameters are used by the Virtual Reference Station processors to calculate standard corrections that are available for all predefined locations in the network. The corrections are transmitted to the user by L-band satellite communication in the standard RTCM SC104 DGPS correction format. This article investigates the performance of the LandStar Mk III system under various operational conditions and assesses its performance in both static and kinematic modes. Four field tests were conducted during 12 months that tested the sysem in clear static and kinematic conditions as well as suboptimal environments associated with low and heavy foliage conditions. Both the accuracy and availability of the system under these conditions is investigated, with an emphasis on whether the above variables are caused by the LandStar system differential corrections, the GPS measurements, or a combination of both. © 1999 John Wiley & Sons, Inc.
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  • 18
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    GPS solutions 2 (1999), S. 57-59 
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  • 19
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    GPS solutions 2 (1999), S. 64-66 
    ISSN: 1521-1886
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    GPS solutions 2 (1999), S. 60-63 
    ISSN: 1521-1886
    Source: Springer Online Journal Archives 1860-2000
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    Notes: From time to time, this column will include short contributions from invited guest contributors on specialized subjects pertaining to inonospheric effects on GPS signals. In this issue, Dr. A. J. Van Dierendonck discusses the required specifications of a civilian GPS receiver specially designed to make quantitative measurements of both ionospheric amplitude and carrier phase scintillation effects from GPS signals. © 1999 John Wiley & Sons, Inc.
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    GPS solutions 2 (1999), S. 52-56 
    ISSN: 1521-1886
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    Notes: A modular approach consisting of three steps is presented for precise positioning with GPS: integrity, monitoring (data validation), ambiguity resolution, and positioning. Results of one step are used as input for the next. After a brief description of reliability and testing and techniques for GPS ambiguity resolution, the observation equations for the geometry-free GPS model are given, used for integrity monitoring, followed by those for single-difference relative positioning with the double-difference ambiguities removed. © 1999 John Wiley & Sons, Inc.
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  • 22
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    GPS solutions 3 (1999), S. 1-1 
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    GPS solutions 3 (1999), S. 2-4 
    ISSN: 1521-1886
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    Notes: GPS technology will face not one but two critical rollover dates over the next eight months. One is the millennium (Y2K) rollover. The other is the GPS week 1024 rollover also known as the GPS End of the Week (EOW). Each rollover dat has the potential to cause severe problems in GPS receivers and related software. This article expolres the reasons why these dates are a problem and describes choices that must be made as to their solution. The paper also describes some verification methods that may be used to test GPS receivers and software. © 1999 John Wiley & Sons, Inc.
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    GPS solutions 3 (1999), S. 17-25 
    ISSN: 1521-1886
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    Notes: The Global Positioning System (GPS), in addition to providing precise navigation and positioning information, produces precise time and frequency measurements. These measurements result from the atomic clocks in the GPS satellites, which are closely coupled to Universal Coordinated Time as maintained by the U. S. Naval Observatory [UTC(USNO)]. The application of these measurements to timekeeping and other systems requiring precise time and frequency is distinct from the navigation/positioning mission. This article will describe the differences in application of GPS to time and frequency uses. These uses will be described in the major areas of timekeeping; stationary uses, such as communications networking; and mobile use for aircraft and shipboard applications. The major considerations in application and operation with precise and less-capable oscilators will be described. Examples and data will be presented to illustrate the applications. © 1999 John Wiley & Sons, Inc.
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  • 25
    ISSN: 1521-1886
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    Notes: High-accuracy real-time GPS-based attitude determination requires that integer ambiguities be resolved very quickly so that the attitude angles can be output with minimum delay. This article describes an attitude determination algorithm that can resolve integer ambiguities instantaneously, relative to one antenna of a multi-antenna array configuration. The carrier phase and pseudorange observations are used with fixed baseline length constraints and fiberoptic gyro data. Real-time stochastic model improvement using empirical elevation-dependent standard deviation function and an estimated scale factor are a feature of this algorithm. Integer ambiguity search using the LAMBDA method, sophisticated validation criteria, and an adaptive procedure has also been implemented within the software. An experiment was carried out using four Leica dual-frequency GPS receivers (but only the L1 carrier phase and pseudorange data were used) and a low-cost fiberoptic on a car. The results indicate that integer ambiguities can be resolved on a single-epoch basis with a 98.9% success rate. © 1999 John Wiley & Sons, Inc.
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  • 26
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    Notes: The 29th Research Institute recently published its latest transformation parameters for WGS and PZ 90. Because these tranformation parameter estimates were derived from stations located within Russia, variance-covariance propagation was carried out to study the benefits of a better global distribution of stations. An example that includes two stations in North America is presented. The transformation improves significantly. © 1999 John Wiley & Sons, Inc.
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    GPS solutions 3 (1999), S. 26-31 
    ISSN: 1521-1886
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    Notes: Considering GLONASS as one of the pillars of the international Global Navigation Satellite System (GNSS), the Russian Federation works toward the integration of GLONASS with other navigation systems, cooperates with the internal user community, and contributes to the development and coordination of standards concerning GLONASS and the combined use of GLONASS and the global positioning system (GPS). This work is pursued in conformity with recommendations of respective international organizations. Most users recognize that the GLONASS/GPS combination has better characteristics in terms of availability, accuracy, integrity, and so on. However, the combined use of these satellite systems raises problems that must be addressed. This article reviews problems encountered when using two different navigation systems. Solutions developed thus far are outlined. The potential of GLONASS and approaches for high accuracy UTC time transfer are discussed. The transformation between the WGS 84 and PZ 90 reference frames and their conformity with the international terrestrial reference frame (ITRF) is considered. Various solutions are viewed in connections with recommendations made by the International Civil Aviation Organization (ICAO), the Global Navigation Satellite System Panel (GNSP), and the Consultative Committee for Definition of the Second (CCDS) concerning the desirability of using either or both systems interchangeably. © 1999 John Wiley & Sons, Inc.
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    GPS solutions 3 (1999), S. 32-41 
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    Notes: The hybridization of GPS with GLONASS has formed a first stage in GNSS development. We examine the performance of the hybrid system in the position domain for both code and carrier phase cases. Several major differences exist between GPS and GLONASS; most significant is GLONASS's signal frequency diversity, which can lead to measurement bias, particularly so when a pair of receivers are operating at different temperatures. Unless signal frequency diversity is addressed either on-receiver or at the data processing stage, positioning errors can occur at the centimeter level. We outline the difficulties of combining observations from the two systems and discuss how these may be overcome. © 1999 John Wiley & Sons, Inc.
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    GPS solutions 3 (1999), S. 42-49 
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    Notes: For many common GPS/GLONASS native receiver formats, a single freeware program called TEQC now allows the user to translate from the binary receiver format to the standard Receiver Independent Exchange (RINEX) format, to edit existing RINEX files, and to quality-check the data before postprocessing. TEQC is 100% noninteractive and has a command line interface modeled after common UNIX commands. This combined with TEQC's extensive documentation makes it simple to use for new and experienced users and in automated processing scripts. © 1999 John Wiley & Sons, Inc.
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    GPS solutions 3 (1999), S. 50-58 
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    Notes: The precise point whose position is being measured when a GPS baseline is determined is generally assumed to be the phase center of the GPS antenna. However, the phase center of a GPS antenna is neither a physical point nor a stable point. For any given GPS antenna, the phase center will change with the changing direction of the signal from a satellite. Ideally, most of this phase center variation depends on satellite elevation. Azimuthal effects are only introduced by the local environment around each individual antenna site. These phase center variations affect the antenna offsets that are needed to connect GPS measurements to physical monuments. Ignoring these phase center variations can lead to serious (up to 10 cm) vertical errors. This article will describe the procedure by which the National Geodetic Survey is calibrating GPS antennas and how this information may be obtained and used to avoid problems from these antenna variations. © 1999 John Wiley & Sons, Inc.
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    GPS solutions 3 (1999), S. 77-78 
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    GPS solutions 3 (1999), S. 59-72 
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    Notes: Since its official start in January 1994, the International GPS Service (IGS) has been distributing, as part of its product combination, two distinct Earth rotation parameter (ERP) series: the IGS Rapid series and the IGS Final series. Initially, the IGS Rapid ERP values were interpolations of the International Earth Rotation Service (IERS) Bulletin A, whereas the IGS Final ERP series was based on the IERS Bulletin B. Since June 1996, the IGS has been generating its own Final ERP series consistent with the IGS combined orbit products and based on weighted means of individual IGS analysis center (AC) solutions. At first, only the polar motion (PM) coordinates and their rates were combined. Length of Day (LOD) and Universal Time (UT) solutions, also based on separate weighted mean combinations, followed in March 1997. Currently, the IGS Rapid and Final combinations are produced and made available within 17 hours and 11 days, respectively, after the last observation. Both IGS and the best AC series are consistent and precise at the 0.1-milliarcsecond (mas) level for PM and at about 30 μs for LOD. Biases in some AC solutions may exceed these consistency levels. Comparisons of both IGS ERP series with external standards, such as the IERS multitechnique Bulletins and atmospheric angular momentum series, confirm the estimated precisions. © 1999 John Wiley & Sons, Inc.
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    GPS solutions 3 (1999), S. 79-81 
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    GPS solutions 3 (1999), S. 73-76 
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    Notes: The Jet Propulsion Laboratory's (JPL's) automated GPS data analysis service, which is available via the Internet, has been tested. This service is attractive not only because data submission and retrieval are entirely automated on the Internet, but also because it makes centimeter positioning possible for individual dual-frequency receivers. To learn more about this service, the repeatability of position solutions were investigated by means of two simple experiments. The positions of a continuously operating reference station have been computed repeatedly for observation times ranging from 1 hour to 24 hours. In addition, short baseline repeatability and accuracy were tested. Centimeter-level results were obtained. The difference in the vertical definition of the electronic center for antennas of different types could readily be identified. The JPL service is easy to use, even in its present form (which one might label version 1.0). © 1999 John Wiley & Sons, Inc.
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    GPS solutions 3 (1999), S. 82-84 
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    GPS solutions 3 (1999), S. 11-18 
    ISSN: 1521-1886
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    Topics: Architecture, Civil Engineering, Surveying , Geosciences
    Notes: In this article, the influence of biases in GPS code observations on the estimated parameters of the geometry-free model is investigated. This is done for undifferenced as well as double-differenced data from short baselines, that is, baselines for which ionospheric effects may be assumed absent. It is shown how introducing a linear model for code multipath affects the original model parameters. The performance of the original and extended model is illustrated by analyzing data from a single receiver and a short baseline. © 1999 John Wiley & Sons, Inc.
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    GPS solutions 3 (1999), S. 19-27 
    ISSN: 1521-1886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Architecture, Civil Engineering, Surveying , Geosciences
    Notes: The Global Positioning System (GPS) and Wide Area Augmentation System (WAAS) provide lower power signals that are susceptible to interference. The potential exists for a person or organization to jam GPS or WAAS signals, causing a loss of service over a large area. Accidental interence by extraneous radio transmissions on the GPS frequency also can cause loss of service. Jamming has become a serious issue for GPS, and the U. S. military is making a significant effort to mitigate jamming effects. While jamming is a major concern of the military, interference is of a no lesser concern to the civilian sector. In fact, with varying emphasis both jamming and interference are concerns of the entire GPS user community. This article explores jamming and interference threats to the GPS. We provide a general overview of the GPS signal structure, discuss jamming effects on the GPS, and consider mitigating options. © 1999 John Wiley & Sons, Inc.
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    GPS solutions 3 (1999), S. 28-39 
    ISSN: 1521-1886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Architecture, Civil Engineering, Surveying , Geosciences
    Notes: The management of the Global Positioning System (GPS) by the U. S. Department of Defense (DoD) has been the subject of persistent criticism by the global community of users in general and particularly in Europe. The European Union (EU) is considering various global navigation satellite systems (GNSS) that would provide it with varying degrees of control, autonomy, and specificity of use. The gamut of options includes various augmentations of GPS, a combination of GLONASS and GPS, and its own GNSS, dubbed Galileo. We discuss the concerns of the global community with respect to GPS and the motives that drive the GPS globalization debate. We also describe the various European GNSS concepts and initiatives, and the likelihood for their realization as substitutes to the GPS. © 1999 John Wiley & Sons, Inc.
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  • 39
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    Notes: Recent studies have shown the capabilities of Global Positioning System (GPS) carrier phases for frequency transfer based on the observations from geodetic GPS receivers driven by stable atomic clocks. This kind of receiver configuration is the kind primarily used within the framework of the International GPS Service (IGS). The International GPS Service/Bureau International des Poids et Mesures (IGS/BIPM) pilot project aims at taking advantage of these GPS receivers to enlarge the network of Time Laboratories contributing to the realization of the International Atomic Time (TAI). In this article, we outline the theory necessary to describe the abilities and limitations of time and frequency transfer using the GPS code and carrier phase observations. We report on several onsite tests and evaluate the present setup of our 12-channel IGS receiver (BRUS), which uses a hydrogen maser as an external frequency reference, to contribute to the IGS/BIPM pilot project. In the initial experimental setup, the receivers had a common external frequency reference; in the second setup, separate external frequency references were used. Independent external clock monitoring provided the necessary information to validate the results. Using two receivers with a common frequency reference and connected to the same antenna, a zero baseline, we were able to use the carrier phase data to derive a frequency stability of 6 × 10−16 for averaging times of one day. The main limitation in the technique originates from small ambient temperature variations of a few degrees Celsius. While these temperature variations have no effect on the functioning of the GPS receiver within the IGS network, they reduce the capacities of the frequency transfer results based on the carrier phase data. We demonstrate that the synchronization offset at the initial measurement epoch can be estimated from a combined use of the code and carrier phase observations. In our test, the discontinuity between two consecutive days was about 140 ps. © 1999 John Wiley & Sons, Inc.
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    GPS solutions 3 (1999), S. 66-68 
    ISSN: 1521-1886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Architecture, Civil Engineering, Surveying , Geosciences
    Notes: GLONASS is a Russian military navigation satellite system. Even if the constellation is far from being operational, a large community is potentially interested in using its signal in combination with GPS to improve availability, integrity, or precision. The goal of this article is to present the international GLONASS campaign, named IGEX-98, which is really the first attempt to obtain precise GLONASS orbits for geodetic applications. A world-wide network of GLONASS receivers has been deployed and is still operational. Several analysis centers process the GLONASS data on a regular basis in the same way it is done for GPS within the International GPS Service. © 1999 John Wiley & Sons, Inc.
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    GPS solutions 3 (1999), S. 48-52 
    ISSN: 1521-1886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Architecture, Civil Engineering, Surveying , Geosciences
    Notes: The use of the Global Positioning System (GPS) for position and attitude determination has been exploited for many years. In these systems, it was required that multiple antennas maintained phase lock to common view satellites for long periods of time in order to determine integer ambiguities. The challenge to overcome with the ballistic space probe is the high rotational spin of this particular rocket. The antennas, mounted on the outside skin of the rocket, are in full view of each satellite only for a fraction of a second before the rocket core eclipses them as it rotates. The antennas rarely see common satellites. This article describes as system that overcomes these obstacles and provides position, acceleration, attitude, and rotation rate. The approach uses a two-antenna system. One antenna is mounted either side of the rocket facing out. A hybrid tracking channel combines signals from both antennas to overcome the signal blockage due to the rocket core as well as to defeat the effect on the tracking channel due to the spin. The amplitude and phase of the spin rotation signature from each satellite is extracted from the dual antenna data and used to compute the attitude and spin rate of the vehicle. © 1999 John Wiley & Sons, Inc.
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  • 42
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    GPS solutions 3 (1999), S. 40-47 
    ISSN: 1521-1886
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    Topics: Architecture, Civil Engineering, Surveying , Geosciences
    Notes: A significant impediment to real-time centimeter survey and vehicle guidance in difficult reception environments is the underlying signal tracking performance of the receiver. A number of researchers have investigated receiver signal tracking enhancements that take advantage of intersatellite path correlations, of particular benefit in environments with multiple satellite attenuations and blockages. This article surveys work in the area, with a focus upon an optimal estimation scheme known as integrated demodulation/navigation (IDN). By contrast with other techniques, IDN employs a high update rate extended Kalman filter to combine and process raw correlator data across satellites. Nonlinear loop simulations of real time kinematic (RTK) tracking during high-g aircraft maneuvers with vehicle-induced blockages are used to illustrate the filtering method and it s robustness. © 1999 John Wiley & Sons, Inc.
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  • 43
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    Notes: With the availability of high-accuracy, differential global positioning system (GPS) results in real-time, there is a new opportunity to use GPS to accurately measure a marine vessel's dynamic draft (settlement and squat) and 3D attitude (roll, pitch, and heading). The National Geodetic Survey (NGS) and the Coast Survey (CS), offices of the National Ocean Service (NOS), National Oceanic and Atmospheric Administration (NOAA), propose to transfer this technology to the shipping industry. The overall goal of this project is to provide the position of a vessel's keel in real time to within 10 cm (about 4 inches) relative to the bottom of the shipping channel. In support of this phase of the project, there were three meetings hosted by the Port of Oakland, California and NOS to discuss the real-time positioning of vessels project. On December 3 and 4, 1996, CS, NGS, Trimble Navigation Ltd., and the U. S. Coast Guard (USCG) performed GPS tests on a USCG buoy-tender ship. GPS data were used to compute the vessel's dynamic draft and 3D attitude. During the test, five receivers continually collected data; one receiver was located at a base station on the USCG pier on Yerba Buena Island, and four were on the ship: two on the stern and two on the bow. CS installed a TSS-335B vertical reference unit (to measure heave, pitch, and roll) in the engine room of the ship. NOS processed the GPS data and computed the vessel's dynamic draft and 3D attitude. The results indicate that the linear equivalent to the vessel's dynamic draft and 3D attitude were accurate to the 10-cm level using GPS. It was also demonstrated how a ship can be used to measure local water-level changes and actual water-level values everywhere it travels. © 1999 John Wiley & Sons, Inc.
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    GPS solutions 3 (1999), S. 72-74 
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  • 45
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    Notes: A. J. VanDierendonck joins the regular contributors to this column to discuss potential solar radio burst effects on GPS. While this topic does not spedivically involve ionospheric effects on GPS, it falls under the general area of environmental concerns that are of importance to the GPS community. © 1999 John Wiley & Sons, Inc.
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  • 46
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    GPS solutions 3 (1999), S. 75-77 
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  • 47
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    European journal of nutrition 38 (1999), S. 133-142 
    ISSN: 1436-6215
    Keywords: Key words Flavonoids – cancer-cell lines – proliferation –, cytotoxicity – apoptosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Medicine
    Notes: Summary Flavonoids are polyphenolic compounds that occur ubiquitously in foods of plant origin. Their proposed protective role in tumor development may prevail especially in the intestinal tract due to direct exposure of intestinal epithelia to these dietary ingredients. We have screened more than 30 flavonoids for their effects on cell proliferation and potential cytotoxicity in the human colon cancer cell lines Caco-2, displaying features of small intestinal epithelial cells, and HT-29, resembling colonic crypt cells. In addition, for selected compounds we assessed whether they induce apoptosis by determining caspase-3 activation. Studies on the dose dependent effects of the flavonoids showed antiproliferative activity of all compounds with EC50 values ranging between 39.7 ± 2.3 μM (baicalein) and 203.6 ± 15.5 μM (diosmin). In almost all cases, growth inhibition by the flavonoids occured in the absence of cytotoxicity. There was no obvious structure-activity relationship in the antiproliferative effects either on basis of the subclasses (i.e., isoflavones, flavones, flavonols, flavanones) or with respect to kind or position of substituents within a class. In a subset of experiments we examined the antiproliferative activities of the most potent compound of each flavonoid subgroup in addition in LLC-PK1, a renal tubular cell line, and the human breast cancer cell line MCF-7. Out of four flavonols tested, three displayed almost equal antiproliferative activities in all cell lines but fisetin was less potent in MCF-7 cells. The flavanones bavachinin and flavanone inhibited growth of Caco-2 and HT-29 cells with lower EC50 values than that obtained in LLC-PK1 and MCF-7 cells. The lower susceptibility of LLC-PK1 and MCF-7 cells towards growth arrest was even more pronounced in the case of the flavone baicalein. Half maximal growth-inhibition in LLC-PK1 and MCF-7 required 2.5 and 6.6 fold higher concentrations than that needed in the intestinal cell lines. The flavonoids failed to affect apoptosis in LLC-PK1 and MCF-7, whereas baicalein and myricetin were able to induce apoptosis in HT-29 and Caco-2 cells. In conclusion, flavonoids of the flavone, flavonol, flavanone, and isoflavone classes possess antiproliferative effects in different cancer cell lines. The capability of flavonoids for growth inhibition and induction of apoptosis can not be predicted on the basis of their chemical composition and structure.
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  • 48
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    Keywords: Key words Dietary fat – adipose tissue – lipolysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Medicine
    Notes: Abstract Variations in total energy intake and composition of daily food play an important role in the regulation of metabolic processes and so, in the control of body weight. This study was designed in order to investigate the effect of a high-fat diet on lipolysis in isolated adipocytes. For this purpose, fourteen Wistar rats were divided into two groups and fed either a standard-fat diet or a high-fat diet ad libitum for 7 weeks. Adipocytes were prepared from fat pads by collagenase digestion and incubated in vitro in the absence or presence of various lipolytic agents. Lipolysis was measured by the release of glycerol into the medium during 90 min of incubation. We observed that a high amount of fat in the diet induced an enlargement of adipose tissue, which was accompanied by a reduction of β-adrenergic agonist-induced lipolysis, that could be due to a loss of β1 and β3-adrenoceptor number or to alterations of their coupling to adenylate-cyclase through the guanine nucleotide regulatory protein. New data about regional differences were provided by comparing two adipose locations (subcutaneous and visceral).
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  • 49
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    Keywords: Key words Wine polyphenols – 8-hydroxy-2'-deoxyguanosine – oxidative damage – 2-nitropropane – 1,2-dimethylhydrazine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Medicine
    Notes: Summary Background: Flavonoids are polyphenolic antioxidants occuring in vegetables and fruits as well as beverages such as tea and wine which have been thought to influence oxidative damage. Aim of the study: We wanted to verify whether a complex mixture of wine tannins (wine complex polyphenols and tannins, WCPT) prevent chemically-induced oxidative DNA damage in vivo. Methods: Oxidative DNA damage was evaluated by measuring the ratio of 8-hydroxy-2'-deoxyguanosine (80HdG)/ 2-deoxyguanosine (2dG) × 10−6 in hydrolyzed DNA using HPLC coupled with electrochemical and UV detectors. Results: We treated rats with WCPT (57 mg/kg p.o.) for 14 d, a dose 10-fold higher than what a moderate wine drinker would be exposed to. WCPT administration significantly reduced the ratio of 80HdG/2dG × 10−6 in liver DNA obtained from rats treated with 2-nitropropane (2NP) relative to controls administered 2NP only (33.3 ± 2.5 vs. 44.9 ± 3.2 × 10−6 2dG; μ± SE; p〈0.05). On the contrary, pretreatment with WCPT for 10 d did not protect the colon mucosa from oxidative DNA damage induced by 1,2-dimethylhydrazine (DMH). 2NP and DMH are hepatic and colon carcinogens, respectively, capable of inducing oxidative DNA damage. Conclusions: WCPT have protective action against some types of chemically-induced oxidative DNA damage in vivo.
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  • 50
    ISSN: 1436-6215
    Keywords: Key words Anthocyanidins – anthocyanins – comet assay – antioxidative potential – oxidized DNA-bases
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Medicine
    Notes: Summary Anthocyanins are common colored plant flavonoids, occurring as glycosides of the respective anthocyanidin-chromophores. Like other flavonoids, anthocyanidins are also expected to have antioxidative and antimutagenic properties in vivo, although only few data are available. To gain more knowledge on possible protective mechanisms in mammalian cells, we have compared their extracellular and intracellular antioxidative potential in vitro and in human colon tumor cells. We used Aronia melanocarpa Elliot anthocyanin (AA) concentrates, fractions thereof, concentrates from Elderberry, Macqui, and Tintorera fruits, as well as pure compounds. In vitro, antioxidative properties of the samples were studied with the ferric reducing ability assay (FRA assay). As a measure of intracellular oxidative/antioxidative effects, H2O2-induced strand breaks as well as oxidized DNA bases were determined in human tumor HT29 clone 19A cells using a microgelelectrophoresis assay (comet test). Major results were that isolated compounds (aglycons and glycosides) and complex plant samples are powerful antioxidants in vitro. In fact their activities by far exceeded those of Trolox and vitamin C in the FRA assay. Also H2O2-induced DNA strand breaks were reduced in cells treated with the complex plant extracts. In contrast, endogenous generation of oxidized DNA bases was not prevented. In summary, the intracellular steady state of oxidized DNA bases is not altered by anthocyanins or anthocyanidins. This findings raises questions with respect to the cancer preventive potential of anthocyanidins within specific tissues, such as the colon. Extracellularly, however, the compounds are potent antioxidants. This points to their potential for providing systemic protection in vivo, e.g., by scavenging oxidants in the blood stream and in the colon. Notably, both aglycons and glycosides have equally strong antioxidant activity.
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  • 51
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    Keywords: Key words Estrone – estrogen – obesity – dietary estrogen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Medicine
    Notes: Summary Background Estrone is a relatively abundant hormone widely distributed in tissues of animal and plant origin. It is a mild estrogen that induces increases in body weigt in experimental animals. The relative abundance of estrone esters in animal tissues suggests that it may also be found in foods, from which it may alter the mechanisms of body weight control. Aim of the study To measure the total estrone content in food and to determine whether this may affect body weight. Methods In the first part of the study, a method was devised for the measurement of total estrone content in food. This was applied to the analysis of estrone content in a variety of food. Finally, hyperlipidic diets (18.6 MJ/kg) with a total estrone content 0.89 ± 0.21 μmol/kg (control group) and 1.37 ± 0.13 μmol/kg (laced with estrone fatty esters) were given to rats during 15 days, in order to determine the influence of dietary estrone on the body mass. Zucker lean (Fa/?) rats weighting initially 200–215 g were used. The total estrone (essentially as fatty esters) content of food was investigated by combining a dried methanol extraction with saponification and measurement of the free estrone evolved through radioimmunoassay. Result The content of estrone was zero in some vegetables, but significant in fruits, meats, and especially fats, both of plant and animal origin. The application of these analyses to a standard recommended diet for humans may result in intakes of more than 1 μmol of estrone per day, a figure comparable to the estrogen production by women. When rats were exposed to a raised estrone content in a fat-rich diet, they significantly increased their body weights, doubling their rate off growth (1.99 g/day) compared with controls (0.81 g/day), but maintaining their plasma composition and the proportions of lipid, water, and protein in their carcasses. Conclusion The widely distributed estrone esters in food and their relatively high concentrations may result in high free hormone intakes in humans. The continued and massive intake of estrone may enhance tissue deposition and lead to obesity.
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    European journal of nutrition 38 (1999), S. 295-296 
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    European journal of nutrition 38 (1999), S. 286-292 
    ISSN: 1436-6215
    Keywords: Key words Plant oils – tocopherols – sister chromatid exchanges
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Medicine
    Notes: Summary Background: Plant fats and oils are major sources of mono- and polyunsaturated fatty acids as well as vitamin E, the major fat-soluble antioxidants in human nutrition. Dietary antioxidants are expected to reduce cancer risk by minimizing DNA damage. Aim of the study: To compare the effects of γ-tocopherol rich corn oil and the mixture of the α-tocopherol rich olive/sunflower oil on plasma concentration of tocopherols and on the frequency of sister chromatid exchange (SCE), an indicator of DNA damage. Methods: This study had a double-blind, cross-over design and was conducted in 20 normal healthy non-smoking males aged 19–31 years. Design included a 2-week adjustment period and two 2-week test periods in which diets containing 30% energy as fat including either 80 g of corn oil (CO) (20 mg α-tocopherol, 100 mg γtocopherol) or 80 g of olive/sunflower oil (OSO) (24 mg α-tocopherol, 2.4 mg γ-tocopherol) as the main fat-source, were given. Blood samples for analysis of SCE rate and content of tocopherols were collected at the beginning (T0), after adjustment (T1) and after the test period (T2) in intervals of 2 weeks. Results: After two weeks of the corn oil diet, the plasma concentration of γ-tocopherol increased but α-tocopherol decreased significantly compared to the olive/sunflower oil diet. The concentration of α-tocopherol increased (CO: 22.99 ± 1.11 vs. OSO: 24.40 ± 1.49 μmol/l) and that of γ-tocopherol decreased (CO: 4.19 ± 0.29 vs. OSO: 2.99 ± 0.25 μmol/l) after the olive/sunflower oil diet. Intake of the corn oil diet was associated with reduced SCE rate and intensity, whereas there was no change in SCE after the olive/sunflower oil diet (CO: 7.66 ± 0.25 vs. OSO: 8.06 ± 0.47 mean SCE/cell). Conclusions: The combination of γ-tocopherol with α-tocopherol in corn oil diet despite the lower α-tocopherol equivalents/diene acid equivalents ratio achieved better protection against DNA damage than α-tocopherol alone in the olive/sunflower oil diet.
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    European journal of nutrition 38 (1999), S. 1-13 
    ISSN: 1436-6215
    Keywords: Key words Pharmacotherapy – obesity – appetite suppressant – thermogenesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Medicine
    Notes: Summary Many new substances are currently being investigated for their usefulness in the pharmacotherapy of obesity. Most drugs interfere with monoamine neurotransmitter (serotonin, noradrenalin, dopamine and histamine) effects and act as an appetite suppressant. Other approaches are to primarily increase thermogenesis (e.g. β3-adrenoceptor agonists), or to decrease fat absorption by inhibiting the pancreatic lipase (orlistat). New promising agents are substances that increase the effect of corticotropin releasing factor (CRF) or urocortin in the brain (CRF-binding protein ligand inhibitor) and a neuropeptide Y (NPY) Y5 receptor antagonist. The clinical relevance of leptin in the therapy of obesity is probably limited, but can not be fully evaluated at the moment. As obesity has a multifactorial basis, all these substances have in common the fact that they can not cure obesity. They should only be used as an adjunct to classical strategies like diet and exercise in severe obesity. For developing new, perhaps even more specific pharmacological agents, further research is needed to understand the individually different genetic and physiological basis of obesity.
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    European journal of nutrition 38 (1999), S. 35-44 
    ISSN: 1436-6215
    Keywords: Key words Carotenoids – lycopene – lutein –α-carotene –β-carotene – oxidation – antioxidant – human
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Medicine
    Notes: Summary Aim of the study: The present study was conducted to investigate changes in the plasma concentration of carotenoids and carotenoid oxidation products, vitamin A, α- and γ-tocopherol, and ubiquinone-10 during a dietary intervention trial with 23 male healthy volunteers. Method: A two week carotenoid depletion period was followed by a daily consumption of 330 mL tomato juice (40 mg lycopene), then by 330 mL carrot juice (15.7 mg α-carotene and 22.3 mg β-carotene), and then by a 10 g spinach powder preparation (11.3 mg lutein and 3.1 mg β-carotene) served with main meals for two weeks, respectively. Blood samples were collected in the morning after an overnight fasting and carotenoids, vitamin A, tocopherols, and ubichinone were analyzed by reversed-phase HPLC. Results: During the tomato juice intervention, plasma concentrations of trans- and cis-lycopene increased 2-fold compared to the depletion period. Lycopene oxidation products could be demonstrated in plasma and were significantly elevated compared to control (p〈0.001). After two weeks of carrot juice consumption, α-carotene and β-carotene concentrations increased 8.6- and 3.2-fold, respectively. Finally, during the spinach consumption period the lutein concentration increased 2-fold, while the β-carotene concentrations were still elevated 2-fold. Conclusions: The moderate change in dietary habits, e.g., the consumption of 330 mL of carotenoid-rich vegetable juices caused significant changes in the plasma carotenoid concentrations, indicating a high bioavailability of carotenoids from the processed vegetable products. The changes in plasma carotenoid concentrations reflected the carotenoid composition of the consumed foods. However, particularly during the tomato juice intervention period the occurrence of lycopene oxidation products and cis-lycopene isomers in plasma was eminent. The formation may be due to antioxidant reactions of lycopene in the organism.
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    European journal of nutrition 38 (1999), S. 51-75 
    ISSN: 1436-6215
    Keywords: Key words Iron – bioavailability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Medicine
    Notes: Summary In this review a broad overview of historical and current methods for the assessment of iron bioavailability was given. These methods can be divided into iron solubility studies, iron absorption studies, endpoint measures, and arithmetic models. The pros and cons of all methods were discussed. First, studies on in vitro and in vivo iron solubility have been described. The disadvantages of iron solubility include the impossibility of measuring absorption or incorporation of iron. Furthermore, only the solubility of nonheme iron, and not heme iron, can be studied. Second, we focused on iron absorption studies (either with the use of native iron, radioiron or stable iron isotopes), in which balance techniques, whole-body counting or postabsorption plasma iron measurements can be applied. In vitro determination of iron absorption using intestinal loops or cell lines, was also discussed in this part. As far as absorption studies using animals, duodenal loops, gut sacs or Caco-2 cells were concerned, the difficulty of extrapolating the results to the human situation seemed to be the major drawback. Chemical balance in man has been a good, but laborious and expensive, way to study iron absorption. Whole-body counting has the disadvantage of causing radiation exposure and it is based on a single meal. The measurement of plasma iron response did not seem to be of great value in determining nutritional iron bioavailability. The next part dealt with endpoint measures. According to the definition of iron bioavailability, these methods gave the best figure for it. In animals, the hemoglobin-repletion bioassay was most often used, whereas most studies in humans monitored the fate of radioisotopes or stable isotopes of iron in blood. Repletion bioassays using rats or other animals were of limited use because the accuracy of extrapolation to man is unknown. The use of the rat as a model for iron bioavailability seemed to be empirically based, and there were many reasons to consider the rat as an obsolete model in this respect. The double-isotope technique was probably the best predictor of iron bioavailability in humans. Disadvantages of this method are the single meal basis and the exposure to radiation (as far as radioisotopes were used). Finally, some arithmetic models were described. These models were based on data from iron bioavailability studies and could predict the bioavailability of iron from a meal.
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  • 57
    ISSN: 1436-6215
    Keywords: Key words Obesity – oleoyl-estrone – leptin – Zucker fa/fa rat – white adipose tissue
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Medicine
    Notes: Summary Background: Oleoyl-estrone elicits powerful slimming effects on lean and obese rats, sparing protein, lowering appetite and maintaining energy expenditure. Leptin synthesis is markedly reduced by oleoyl-estrone. However, this effect is not observed in the obese Zucker fa/fa rats; these rats do not fully respond to leptin but they lose fat under oleoyl-estrone treatment. Aim of the study: To determine the role of leptin in the conversion of estrone to fatty-acyl estrone in white adipose tissue both in vivo in Zucker lean and obese rats, and in vitro. Methods: Two series of experiments were performed: a) Growth and differentiation of 3T3L1 preadipocytes into adipocytes followed by incubation with tritium-labeled estrone in the medium in the presence / absence of 1 nM leptin, and estimation of the incorporation of label into estrone and estrone ester fractions of cell extracts. b) Zucker lean (Fa/?) [ZL] and obese (fa/fa) [ZO] rats were injected i.v. with carrier-free oleoyl-estrone in chylomicra-sized liposomes, then euthanized after 10 min. Free and esterified estrone were measured in blood, liver, muscle, skin, white adipose tissue (WAT), and brown adipose tissue(BAT). Results: In the first study, in a 72-h incubation, adipocytes took up 20-27% of the medium estrone. In the leptin(−) controls, 47% of the label in the cell fraction was in the form of estrone esters and 45% as free estrone; in the leptin (+) cells, 71% of the label was in the estrone ester fraction and 24% was free estrone. In the second study, a large part of the injected tritium-label remained in the ZO blood, with only a small part remaining in ZL. In ZL 39% of the label was found in the tissues in the form of free estrone, and in ZO only 22%; in both cases about half of it was in WAT. Plasma free estrone levels were 0.3±0.1 nM in ZL and 0.5±0.3 nM in ZO, and esterified estrone was 242±99 nM for ZL and 201±29 nM for ZO. Plasma leptin levels were 1.73±0.16 ng/ml in ZL and 61.0±1.4 ng/ml in ZO. Conclusion: The presence of an intact leptin pathway is critical for the uptake and synthesis of estrone esters as well as for the plasma acyl-estrone turnover. The presented results show a direct relationship between oleoyl-estrone and leptin in the WAT. A fully functional leptin pathway is needed for the synthesis of acyl-estrone and the removal of free estrone from the bloodstream, as well as for the disposal of excess circulating oleoyl-estrone. This has a direct bearing on human and animal obesity, since estrone induces increases in fat deposition.
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  • 58
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    European journal of nutrition 38 (1999), S. 143 
    ISSN: 1436-6215
    Keywords: Key words Phytoestrogen – cholesterol – DNA damage – comet assay – antioxidant
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Medicine
    Notes: Summary Background: Phytoestrogens are a major component of Asian diets and may be protective against certain hormone-dependent cancers (breast and prostate) and coronary heart disease. They may also have antioxidant function in scavenging potentially harmful free radicals and thus decreasing oxidative attack on DNA. Aims of the study: A pilot study to determine the effects of a phytoestrogen supplement, in the form of soy milk, on plasma LDL and HDL cholesterol levels and DNA damage in men. Methods: Ten healthy men participated in the study and were assigned to one of three groups consuming 1 litre of either soy milk, rice dream (vegetable protein control) or semi-skimmed cow's milk (animal protein control) each day for 4 weeks. Results: The soy supplement caused significant increases in plasma genistein and daidzein concentrations despite considerable interindividual variation (P〈0.001). Supplementation with soy resulted in a decrease in oxidative damage to DNA bases detected using the comet assay compared with controls (P〈0.05). However, there was no significant effect of the soy supplement on plasma cholesterol or triglyceride levels in comparison with control groups. Conclusions: A 4 week soy milk supplementation in healthy volunteers does not alter serum cholesterol levels but can have a protective effect against oxidative DNA damage in lymphocytes.
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  • 59
    ISSN: 1436-6215
    Keywords: Key words green tea – linoleic acid – antioxidants – lipid peroxidation – hemostasis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Medicine
    Notes: Summary Background: Green tea contains polyphenolic catechins which can act as antioxidants and thus decrease the risk for cardiovascular diseases. Aim of the study: To investigate whether green tea extract differs from placebo in its effects on markers of antioxidant status, lipid peroxidation, nitric oxide production, thromboxane production, and blood coagulation during a controlled high linoleic acid diet in healthy subjects. Methods: Twenty healthy non-smoking females (23–50 years) participated in a 4-week controlled intervention study. The experimental diet was rich in linoleic acid (9 en%) and contained fat, protein and carbohydrates: 27, 14, and 59 en%, respectively. In addition, the subjects ingested encapsulated green tea extract (3 g/d) or placebo mixture in a double-blind manner. Fasting blood samples and five 24-hour urines were collected before and at the end of the 4-week experimental period. Same samples were received from 10 control subjects. Results: Green tea extract significantly decreased plasma malondialdehyde (MDA) concentration in comparison with the placebo treatment. The treatments did not differ in serum lipids, indicators of antioxidant status, urinary 8-iso-prostaglandin F2α, 2,3-dinor-thromboxane B2, nitric oxide metabolites or coagulation indicators. Conclusions: We conclude that an amount of green tea extract which corresponds to 10 cups of tea per day for 4 weeks does not have specific effects on several indicators related to risk of cardiovascular diseases in comparison with placebo treatment. The relatively small but significant decrease in lipid peroxidation indicated by decreased plasma MDA was not associated with changes in markers of oxidative stress (urinary 8-iso-prostaglandin F2α and blood oxidized glutathione) or hemostasis.
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  • 60
    ISSN: 1436-6215
    Keywords: Key words Long chain polyunsaturated fatty acids – peroxidation – vitamin E – weanling rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Medicine
    Notes: Summary Background: Tissue 10:4(n-6) and 22:6(n-3) status have been correlated with neonatal development and growth. Artificial formulas for neonates have been supplemented with long chain polyunsaturated fatty acids (LCP) from animal and marine sources which may enhance sensitivity of cellular membranes to oxidative damage. Diet-derived antioxidants like vitamin E play a key role in the protection of tissue lipids against oxidation. Aim of the study: We seek to determine the influence of dietary vitamin E on tissue sensitivity to oxidative stress in rats fed for 4 weeks on diets enriched in (n-3) and (n-6) long-chain polyunsaturated fatty acids. Methods: Weanling rats received 10% fat diets that provided 18:1(n-9), 18:2(n-6) and 18:3(n-3) in a similar ratio to that of rat milk (group A), supplemented with fish oil (groups B and B+E) and supplemented with (n-6) and (n-3) LCP from an animal phospholipid concentrate (groups C and C+E). Vitamin E (500 mg vitamin E/kg fat) was added to diets B+E and C+E. Tissue fatty acid content and the activities of catalase, superoxide dismutase, glutathione transferase und glutathione peroxidase in liver and brain were measured. Glutathione status, vitamin E and the production of thiobarbituric acid reactive substances (TBARs) after incubation of erythrocyte, liver and brain lipids with inducers of enzymatic or non-enzymatic lipid peroxidation was measured. Results: Group B registered significantly lower total superoxide dismutase acitvity than group B+. Catalase activity was significantly higher in group C than in group C+E. Hepatic total and reduced glutathione levels were decreased in vitamin E supplemented groups compared to unsupplemented ones. TBARs production in erythrocyte lipids was significantly higher in groups B and C compared to vitamin E supplemented groups B+E and C+E. Conclusions: This study shows that the addition of vitamin E protected erythrocyte and liver microsome lipids enriched in (n-3) and (n-6) LCP from lipid peroxidation during the postnatal development of rats. The protection was more effectively in group C+E than in group B+E.
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  • 61
    ISSN: 1436-6215
    Keywords: Key words Children – adolescents – nutrition counselling – dietary evaluation – scores
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Medicine
    Notes: Summary An intervention study by documented dietary counselling was carried out in a sample of 9 children and adolescents (12–,15 years) living in a full-time institution in Dortmund. Three weighed dietary records were collected over 3–7 days, one before and one after each of two individual nutrition counselling sessions, which were based on the recommended intake of food groups defined by the Optimized Mixed Diet (OMD), a quantitative preventive dietary conception for children and adolescents. As univariate dietary parameters (e.g., cholesterol intake), which are often used to show the effectiveness of nutrition counselling, do not take into account the multivariate complexitiy of nutrition, we developed 3 multivariate scores to measure the effectiveness of nutrition counselling. The are definded as: Recommended Food group change Score (RFS): Average change in the amounts of the deviations (%) from the reference food groups values (OMD = 100 %) before and after counselling taking into account the aim (eat mor/less) of the counselling session, exclusively based on the food groups addressed during counselling. Total Food group change Score (TFS): Average change in the amounts of the deviations (%) from the reference food group values (OMD = 100 %) before and after counselling based on all food groups consumed. Nutrient Improvement Score (NIS): Average change in the negative deviations (%) of 8 vitamins and 8 minerals from the German reference values for nutrient intake (Deutsche Gesellschaft für Ernährung (DGE) = 100 %) before and after counselling. On average, the intakes of the food groups mentioned during the first counselling session improved considerably (RFS = +36 %), the change in the intake of all food groups was small (TFS = +6 %) and the nutrient intakes did not improve (NIS = 0 %). From the second counselling session the values of the RFS was +10 %, of the TFS was +6% and of the NIS +3 %. This means that the success of counselling on one dietary criterion does not guarantee success on others. Our food and nutrient based scores together with a detailed food intake assessment give an example of multivariate measurements of nutrition counselling outcomes.
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  • 62
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    European journal of nutrition 38 (1999), S. 218-226 
    ISSN: 1436-6215
    Keywords: Key words Sugar alcohol – lactitol – breath hydrogen – lactose malabsorption – gastrointestinal symptons – diarrhea
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Medicine
    Notes: Summary The hydrogen breath analysis test was performed in healthy Thai adults to determine lactitol tolerance. The study was conducted in 39 individuals (11 males and 28 females) aged 18–41 years. All volunteers agreed to participate in this study after the risks and benefits had been fully explained. Subjects were requested not to consume milk, milk products, or high-vegetable diets for a day and to fast from 10 p.m. of the day preceding the test day. After consumption on the test diet (12 and 20 g of lactose or lactitol, respectively, in 250 mL water), the subjects recorded the severity of symptoms for 24 hours. Breath samples were collected after fasting and after consumption of the test diet at 30 min intervals over the 7-hour study period. Breath samples were analyzed for hydrogen using gag chromatography. After consumption of 12 g lactose, the prevalence of lactose malabsorbers was established. The increment of a peak breath hydrogen level of ≥ 20 ppm above the baseline level was used as an indicator of lactose malabsorption. The lactose malabsorbers were further classified as lactose tolerants or lactose intolerants according to the gastrointestinal symptoms observed. All 39 healthy Thai adults could be classified into 3 groups as follows: 9 (23%) lactose absorbers (LA), 15 (38.5%) lactose malabsorber/tolerants (LMT) and 15 (38.5%) lactose malabsorber/intolerants (LMI). Using the hydrogen breath test, 67% of the subjects were identified as lactitol intolerants after the consumption of 12 g lactitol. The lactitol intolerants comprised 53.8% of LMI, 34.6% of LMT, and 11.5% of LA. Among all subjects, one third of LA (33%), two thirds of LMT (60%), and 93% of LMI were lactitol intolerant. In addition, gastrointestinal symptoms such as flatulence and abdominal pain were most pronounced in LMI. Diarrhea was also a prominent manifestation after consumption of 12 g lactitol. Therefore, it was finally decided that 20 g lactose or lactitol were not given to LMI because of the risk of gastrointestinal symptoms. After high doses (20 g) of lactose and lactitol consumption, most LMT developed more symptoms than did LA and the main symptom was diarrhea. Consumption of 20 g lactose resulted in fewer symptoms than 20 g lactitol in both LA and LMT. On the basis of the hydrogen breath test, most LA tolerated 12 g lactitol without gastrointestinal symptoms except some flatulence whereas most LMT and LMI did not. Twenty g lactitol was not tolerated by both LA and LMT because there was diarrhea among the subjects, especially in LMT. Although the hydrogen breath analysis test is the best method for identification of lactose malabsorption, it is not the best method to identify lactitol intolerance. A hydrogen concentration of 15 ppm above the baseline level was found to be the best cut-off point to indicate lactitol intolerance although sensitivity was 85% and specificity only 38% in this study. It was further concluded that there is a greater susceptibility to lactitol in human lactose malabsorbers than in lactose absorbers. Our findings might be relevant for the limited use of lactitol in Thailand.
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  • 63
    ISSN: 1436-6215
    Keywords: Key words Ergogenics – amino acids – exercise – arginine aspartate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Medicine
    Notes: Summary Background: Athletes consume arginine and/or aspartate as potential nutritional ergogenics. Their metabolic effects are controversial and there is some evidence that ingestion of large doses of single amino acids can adversely affect the nitrogen balance or induce an amino acid imbalance. Nevertheless, the general metabolic influence of an arginine aspartate supplementation during a prolonged exercise bout has not yet been investigated. Aim of the study: The aim of this study was, therefore, to investigate the general metabolic impact of a chronic supplementation with arginine aspartate in endurance-trained athletes at rest and during a marathon run. Methods: Fourteen endurance-trained runners participated in this field study which was carried out according to a double-blind crossover design. 15 g of arginine aspartate or a carbohydrate-based placebo were supplemented daily for 14 days before a marathon run. Blood samples for analysis of metabolites and hormones were collected shortly before the run, after 31 km, at the end of the run, and after a recovery period of two hours. Additionally, the respiratory exchange ratio was determined during the run. Results: The plasma level of carbohydrate (glucose, lactate, pyruvate) and fat metabolites (fatty acids, glycerol, β-hydroxybutyrate), cortisol, insulin, ammonia, lactate dehydrogenase, and creatine kinase as well as the respiratory exchange ratio were unaffected by the supplementation. In contrast, the plasma level of somatotropic hormone, glucagon, urea, and arginine were significantly increased, and the level of most of the remaining plasma amino acids as well as their sun was significantly reduced. Conclusions: There was no obvious metabolic benefit derived from the chronic supplementation with arginine aspartate. And since furthermore the consequences of a reduction of the total plasma amino acid level are not known, the practice of using single amino acid supplements as potential ergogenics should be critically reevaluated.
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  • 64
    ISSN: 1436-6215
    Keywords: Key words Conjugated linoleic acid – hormones – metabolites – lipoproteins – fatty acids – swine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Medicine
    Notes: Summary Background: Conjugated linoleic acids (CLA)# refer to a group of linoleic acid (18:2)-derived isomers with conjugated double bonds mostly at carbon atoms 9 and 11 or 10 and 12, and with all possible cis and trans combinations. CLA is a newly recognized nutrient that functions to regulate energy retention and metabolism and that causes a serum lipoprotein profile considered to be less atherogenic. However, rodent models that have been frequently used for these studies are only of limited use because of distinct differences in physiology, compared with man. Additionally, possible differences in food intake between the experimental groups remained often unconsidered in those studies. Thus, it can not be excluded that the beneficial effects of CLA reported in a series of studies may be due, at least partially, to differences in nutrient and energy ingested. Aim of the study: This prompted us to undertake an investigation on the action of CLA by using a pig model and a feeding regimen with controlled amounts of food and antioxidants. The parameters used to assess CLA-specific action were selected hormones and metabolites involved in energy metabolism, individual lipoproteins and the appearance of CLA in fasting serum and erythrocyte membranes. Blood as an easily available biological sample was used for investigation. Methods: For that purpose 16 adult female pigs were divided into two groups of 8 each, and were isoenergetically fed diets containing 0 (control diet) or 1% level of CLA (by weight) for 6 weeks. Plasma concentrations of total and free thyroxine (T4), total and free triiodothyronine (T3), and insulin were measured by radioimmunoassays. Plasma non-esterified fatty acids (NEFA), β-hydroxybutyrate, circulating blood ATP and other clinical chemical variables were determined using enzymatic assays. The concentration of α-tocopherol was determined by high perfomrance liquid chromatography. The lipoproteins VLDL (density 〈1.019 kg/L), LDL (density 1.019 – 1.063 kg/L), and HDL (density 〉1.063 kg/L) were isolated by step-wise ultracentrifugation. Fatty acids of the dietary oils, serum and blood cell membranes were separated and quantified by gas chromatography. Results: At week 6, body weights of the pigs fed the CLA-supplemented diet were not different from that of the controls. CLA-treated pigs exhibited a 37% higher concentration of fasting serum insulin than their controls receiving no CLA (P = 0.11). Circulating free and total T4 and T3 as well as serum levels of β-hydroxybutyrate, α-tocopherol, protein, glucose, urea, creatinine and circulating blood ATP remained unaffected by CLA supplementation. Serum concentrations of non-esterified fatty acids were reduced by 38% in CLA-treated pigs relative to the controls, although this difference was not significant. CLA-treated pigs tended to have lower leukocyte counts in blood than their controls (P 〈0.1). Erythrocyte and platelet counts, the hematocrit and hemoglobin concentration were similar between the groups. Serum of CLA-treated pigs showed a trend toward increased levels of triacylglycerols, cholesterol and phosphatidylcholine in the very low density and low density lipoproteins (LDL), without distinct changes in the high density lipoprotein fraction (HDL). The LDL cholesterol to HDL cholesterol ratio was significantly increased by CLA. When pigs were fed CLA at a dietary level of 1%, limited proportions of CLA appeared in fasting serum (1.6%) and erythrocyte membranes (1.1%). Conclusions: Under the present experimental conditions there appeared to be parallels between the effects of CLA and the reported effects of trans fatty acids in the mode of action on lipoproteins and insulin. The failure to demonstrate significant beneficial effects of CLA on the lipoprotein profile which have been observed in other studies requires further research.
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  • 65
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    Lasers in medical science 14 (1999), S. 2-19 
    ISSN: 1435-604X
    Keywords: Keywords: Corneal topography; Fluorescence; Holography; Interferometry; Moiré; Partial coherence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Physics , Technology
    Notes: Abstract. Corneal topography has, due to developments in refractive surgery and contact lens fitting, become a widely used diagnostic tool. Many types of topographers have been introduced, but there is some confusion on classification and subsequent principal possibilities of the various devices offered to the practitioner. The purpose of the study reported here was to make an inventory of developed devices, analyse the basic principles and create a classification based on optical principles. A literature search was done using Medline, the IBM Patent Server, and references found in articles and patents. This search resulted in a variety of descriptions that could be classified into 12 groups according to their use of light source and light-matter interaction of which four groups have representatives on the commercial market. This classification can be used by researchers and practitioners to gain insight into the possibilities of a given device in relation to the desired application.
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  • 66
    ISSN: 1435-604X
    Keywords: Keywords: Interstitial laser coagulation; Laser applicator; Laser induced thermotherapy; Liver tumours; Nd-YAG laser
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Physics , Technology
    Notes: Abstract. A newly developed diffusing laser applicator was examined for interstitial laser coagulation (ILC) of liver tumours. The applicator consisted of a matted quartz core and a quartz glass dome, also matted on its inner surface and sealed to the fibre. The applicator provided a homogeneous light intensity distribution over an active length of about 20 mm. Lesions were created in an ex-vivo porcine liver model using a Nd-YAG laser comparing the new diffusing tip with a Ringmode®-ITT applicator in order to find optimal laser parameters and damage thresholds. The lesions were investigated using macroscopic size measurement, volume calculation and histological examination (H&E, NADPH-dehydrogenase). The damage threshold of the diffusing tip was 6 W at 14 min exposure time whereas the Ringmode®-ITT applicator had its limit at 5 W and 12 min exposure. Comparing various exposure times showed that treatment over a time of more than 840 s did not significantly increase the lesion volume. At 5 W and 720 s the mean lesion volume was 6.9±1.1 cm3 with the diffusing tip and 6.3±0.6 cm3 with the Ringmode®-ITT applicator, both having a slight ellipsoidal shape. Hence, the created lesions were not significantly different for both applicators when the same laser parameters were applied. On the other hand, the new diffusing tip had a higher damage threshold and was therefore capable of producing maximal coagulation volumes of up to 7.9±0.5 cm3 at 5 W and 20 min. The experiments showed that lesions with a dimension of 31×22 mm can be achieved with the diffusing applicator which seem suitably sized for treating small human liver metastases in a single laser session.
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  • 67
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    Lasers in medical science 14 (1999), S. 62-66 
    ISSN: 1435-604X
    Keywords: Keywords: Laser myringotomy; Otitis media with effusion; Tympanic membrane
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Physics , Technology
    Notes: Abstract. A prospective comparative study was done to assess the validity of laser myringotomy (L-myringotomy) when compared to the insertion of ventilating tubes (VT). In 23 children with chronic otitis media with effusion, a VT was inserted in the left ear while a laser myringotomy was performed in the right ear by using the CO2 Sharplan 1030 laser. After a six month follow-up conducted during the winter months, the results with the laser myringotomy were equal to those in the left ear with the VT. During the follow-up period, three ears required additional laser myringotomy either for early closure or because of otitis media and the accumulation of effusion in the middle ear cavity. Nevertheless, the use of laser has the advantage that there is no foreign body in the ear, the tympanic membrane is closed after four to seven weeks, and since the procedure is very short, the time for anaesthesia is minimal.
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  • 68
    ISSN: 1435-604X
    Keywords: Keywords: Chorioallantoic membrane (CAM); Liposomes; Methylene blue; Ovarian cancer; Photodynamic therapy; Photosensitiser
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Physics , Technology
    Notes: Abstract. The disappointing results with either surgery alone and/or chemotherapy in the treatment of malignant ovarian tumours have led to an increased interest in additional treatment schedules. Photodynamic therapy (PDT), a modality involving the use of a photosensitising drug and activating light, is being used increasingly as a local treatment for neoplastic lesions. The synthesis and evaluation of new photosensitisers for the treatment of gynaecological lesions and malignancies continues to be an active area of investigation for proper application of the photodynamic process in the gynaecological field. The effect of PDT using methylene blue (free and combined with liposomes) as a photosensitiser for treating human ovarian malignant tumours cultivated on the chorioallantoic membrane was evaluated. Two days after PDT, the treated implanted tumours were markedly decreased in size. Areas of necrosis with black coloration, dryness and eschar formation were observed. Five days after PDT, tumour remission was clearly observed in all the treated tumours. Photodynamic therapy using methylene blue (aqueous and coupled with liposomes) is effective for treating the ovarian malignancies and it will be capable of achieving complete eradication of visible tumours in patients with superficial lesions.
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  • 69
    ISSN: 1435-604X
    Keywords: Keywords: Aminolaevulinic acid; Dermatology; Photodynamic therapy; Photosensitisation; Protoporphyrin IX; Skin lesions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Physics , Technology
    Notes: Abstract. The method of surface-detected fluorescence has been used to monitor the emission intensity from 5-aminolaevulinic acid (ALA)-induced protoporphyrin IX (PpIX) in lesions and corresponding adjacent normal skin. Three types of lesions were examined: psoriatic plaques, actinic keratosis and basal cell carcinoma. This study included a total of 14 human volunteers on whom ALA-induced PpIX formation and clearance was monitored for a total of 48 h post-ALA application. Both an ALA dose-ranging study, as well as a comparison of results between normal and lesional tissue at a fixed ALA dose, were carried out. For the dose range examined (10–30%), there was no ALA dose dependency of the PpIX fluorescence for any of the lesions tested. Although all three lesions tested did show enhanced PpIX fluorescence as compared with normal skin, there was considerable lesion-to-lesion variability. Thick psoriatic plaques seem to give longer PpIX retention times than those of thin lesions. Limitations of the surface-detected fluorescence methodology are discussed.
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  • 70
    ISSN: 1435-604X
    Keywords: Keywords: Interstitial laser therapy; Liver; Perfusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Physics , Technology
    Notes: Abstract. Interstitial laser Doppler flowmetry was used to measure the effect of interstitial laser-induced thermotherapy on local blood perfusion in normal rat liver in the peripheral treatment region elevated to hyperthermic temperatures. The Nd:YAG laser emitting at 1064 nm was utilised as heat generation source. The plane-cut tip of an optical fibre was placed in the middle of the exteriorised left liver lobe. Blood perfusion and temperature were measured in the liver parenchyma 4 mm from the laser fibre. The temperature at the location of the liver temperature sensor was maintained at 41 or 44°C during 30 min by regulating the power of the heating laser. The laser Doppler signal was recorded during and after heat treatment, for a total time of 60 min. At 41°C, a significant increase in perfusion up to 1.3 times the initial value was observed 2–16 min after start of treatment. At 44°C, perfusion decreased continuously during and after treatment, and was significantly different from control 40 min after start of treatment. The results may be valuable in assessing the thermal response of tissues surrounding the target in interstitial laser-induced thermotherapy of liver tumours during conditions of normal blood flow.
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  • 71
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    Lasers in medical science 14 (1999), S. 168-174 
    ISSN: 1435-604X
    Keywords: Keywords: Endodontics; Laser ablation; Nd:YAG laser; Picosecond laser; Root canal therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Physics , Technology
    Notes: Abstract . The interaction of picosecond laser radiation with human dental tissue was investigated in this study, in order to determine the ablation rates and the surface characteristics of the dentine by using scanning electron microscopy (SEM). Dentine ablation was performed by using tooth sections of different thicknesses (0.5–2.0 mm). Dental tissue samples were irradiated in air with the fundamental wavelength and first harmonic of a regenerative amplifier Nd:YAG laser system, at 1064 nm and 532 nm, respectively, with a pulse duration of 100 ps and a pulse repetition rate of 10 Hz. The results showed very clean craters surrounded by minimum melting of the surface of dentine when the 1064 nm pulses were used. In contrast, when the first harmonic 532 nm pulses were used, the SEM examinations revealed cracks and melting of dentine with irregular surface modification. Consequently, it seems that cleaning and shaping of the root canal walls during endodontic therapy with the picosecond Nd:YAG laser application may be possible in the future. The, as yet unexplored, field of the picosecond laser interaction with hard dental tissue is expected to be a potential alternative for powerful laser processing of biomedical structures.
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  • 72
    ISSN: 1435-604X
    Keywords: Keywords: Chlorins; Firing; Janus green B; Methylene blue; Neuron; Photodynamic effect; Photoheme; Photoporphyrin IX; Photosens; Photosensitisers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Physics , Technology
    Notes: Abstract . The study of single neuron response to photodynamic effect provides a means for the study of the dynamics of cytotoxic events leading to cell death and allows comparison of the phototoxicity of different photosensitisers. Isolated crayfish stretch receptor neurons were photosensitised for 30 min, then irradiated with a He-Ne laser (632.8 nm; 0.3 W/cm2) until irreversible firing cessation. The dynamics of neuron firing frequency were continuously recorded throughout. The following photosensitisers were studied: methylene blue, janus green B, protoporphyrin IX, chlorins e 6 and p 6, haematoporphyrin derivative (Photoheme) and sulphonated aluminium phthalocyanine (Photosens). Nerve cells were found to be insensitive to either He-Ne laser irradiation or photosensitisation alone, but very vulnerable to the photodynamic effect: neurons changed firing rate and died at nanomolar concentrations of photosensitisers. The dynamics of neuron responses was found to depend on photosensitiser type and concentration. The current approach provides a means of evaluation of initial threshold cell membrane alteration and cytotoxic events leading to cell death. The dependence of firing acceleration rate and neuron lifetime on photosensitiser concentration additionally allowed comparison of efficiencies of different photosensitisers. Photosens, Photoheme and chlorin p 6 were found to be the most potent photosensitisers: neurons responded to their photodynamic effects at concentrations as low as 1–5 nM.
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  • 73
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    Lasers in medical science 14 (1999), S. 73-80 
    ISSN: 1435-604X
    Keywords: Keywords: Biocides; Disinfection; Laser; Optical fibre
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Physics , Technology
    Notes: Abstract. In order to set up a disinfection protocol, the tip of the optical fibre of an Nd-YAP laser, λ=1.34 μm, was contaminated in vitro with: Mycobacterium smegmatis (CIP 7326), Candida albicans (ATCC 2091), Bacillus stearothermophilus (ATCC 7953) or Streptococcus sanguis (ATCC 10556). It was then treated with various biocidal solutions, Septinol® V, glutaraldehyde 2%, ethanol 95° and NaOCl 6%, using one of two protocols: 10 s of contact, or 5 s of contact followed by 5 s of wiping. The latter technique proved to be the most effective. Whatever the biocidal solution used, all the bacteria adhering to the fibre were eliminated. The protocol was checked in vivo in the canals of 10 teeth presenting root canal infections. No bacteria withstood the treatment with Septinol® V. This treatment does not alter the qualities and performance of the fibre as far as light transmission is concerned.
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    Lasers in medical science 14 (1999), S. 105-108 
    ISSN: 1435-604X
    Keywords: Keywords: Glaucoma, open angle; Intraocular pressure; Laser surgery; Trabecular meshwork; Trabeculoplasty
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Physics , Technology
    Notes: Abstract. A randomised prospective study was carried out to determine whether diode laser trabeculoplasty (DLT) is as effective as argon laser trabeculoplasty (ALT) in the control of primary open angle glaucoma (POAG). Forty eyes of 40 patients with uncontrolled intraocular pressure (IOP) despite maximum topical medication were entered into the study. Twenty eyes received DLT, spot size 100 μm, exposure time 0.2 s, mean power 1034 (±56.4) mW. Twenty eyes received ALT, spot size 50 μm, exposure time 0.2 s, mean power 528 (±44.7) mW. They were reviewed at 2 h, 2 and 8 weeks, and 3, 6, 12, 18 and 24 months after laser treatment. Two eyes were withdrawn from the DLT group and four from the ALT group because of uncontrolled IOP during follow-up. Of the remaining eyes in the trial, mean IOP reductions for DLT and ALT, respectively, were: 6 months 7.42 (±2.36) mmHg and 6.36 (±2.3) mmHg; 12 months 7.02 (±2.6) mmHg and 6.28 (±2.2) mmHg; 18 months 6.86 (±2.8) mmHg, 5.98 (±2.02) mmHg; 24 months 6.50 (±2.72) mmHg, 5.92 (±2.02) mmHg. There was a significant reduction in each laser group when IOP at each stage was compared with baseline (p〈0.001) (paired Student's t-test), but no significant difference between the two groups. In the ALT group peripheral anterior synechiae developed in four eyes and post laser pain in seven eyes. These complications were not noted following DLT. We conclude that DLT and ALT are equally effective in IOP control, but DLT is associated with less anterior segment inflammation.
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  • 75
    ISSN: 1435-604X
    Keywords: Keywords: Colour-coded duplex sonography; Laser induced thermotherapy; Minimal invasive therapy; Recurrent breast cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Physics , Technology
    Notes: Abstract. The effect of laser-induced thermotherapy (LITT) as a palliative method for treatment of patients with local recurrence of breast cancer is investigated. This report describes the use of interstitial laser photocoagulation to manage such lesions. The interstitial laser applications were performed in seven women with locally recurrent breast carcinoma on the chest wall after mastectomy. All patients had been heavily pretreated with conventional modes of therapy (radiotherapy, chemotherapy, hormonal therapy, surgical resection). A Nd:YAG laser with a wavelength of 1064 nm was used to heat the lesions. Heat expansion was controlled digitally and monitored by ultrasonography and colour-coded duplex sonography (CCDS). In five women this minimally invasive method enabled the precise coagulation of the subcutaneous tumour without destruction of the skin or ulceration, although these areas had been pretreated by irradiation up to 60 Gy. In two patients with extensive multiple metastases and with skin infiltration, secondary skin ulceration and delayed healing was observed. For palliative reasons, LITT under CCDS guide can aid in local control of chest wall recurrence following mastectomy in selected patients.
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  • 76
    ISSN: 1435-604X
    Keywords: Keywords:Candida albicansCandidosis; Hyphae; Lethal photosensitisation; Toluidine blue O; Yeast
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Physics , Technology
    Notes: Abstract. Oral infections due to Candida albicans are a common occurrence in patients with acquired immunodeficiency syndrome (AIDS). The purpose of this investigation was to determine whether the yeast and hyphal forms of the organism could be killed using the light-activated antimicrobial agent toluidine blue O (TBO). Three variables were investigated: TBO concentration, laser light dose and pre-irradiation time (PIT). Irradiation with light from a helium neon (HeNe) gas laser used in conjunction with the photosensitiser TBO resulted in substantial kills of both the yeast and hyphal forms. Killing was light dose-dependent with 42 J being the most effective dose. The optimum PIT for the yeast form was 5 min, whereas killing of the hyphal form was not affected by PIT. The results of this study have shown that both forms of C. albicans are susceptible to lethal photosensitisation using TBO in conjunction with HeNe laser light, suggesting the possibility that this approach could be useful for eliminating the organism from diseased lesions in vivo.
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  • 77
    ISSN: 1435-604X
    Keywords: Keywords: Beamsplitter; Liver; Metastases; Nd:YAG; Tumour
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Physics , Technology
    Notes: Abstract . Simultaneous application of multiple fibres could increase the volume of coagulation produced with interstitial laser photocoagulation (ILP) for solid tumours. To take full advantage of the presumed synergistic thermal effect between the fibres, the optimal combination of laser power and distance between the fibres was investigated. Four fibres with a cylindrical diffusing tip of 2 cm length were used, coupled to an optical beamsplitter for Nd:YAG light (four channels, maximal variation 9.5%, transmission 〉85%). The distance between the fibres was 1, 1.5, 2, 2.5 , 3 or 4 cm with a power output of either 4, 5, 6 or 7 W/fibre; energy per fibre was constant at 1800 J by adjusting exposure time. After laser application, dimensions of the coagulated lesions were measured. The optimal mutual fibre distance was 2 cm ( p〈0.01) at all power levels. This resulted in lesions with a mean (SD) volume of 44.5 (2.1) cm3 and a largest diameter of 5.1 (0.4) cm at 7 W/fibre. Smaller distances between the fibres resulted in smaller lesions with central carbonisation, whereas larger distances resulted in four separate zones of coagulation. It was concluded that simultaneous application of four interstitial fibres may result in a considerable increase of volume of coagulation. Fibre position and mutual fibre distance determines whether synergism of the coagulative effect occurs.
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    Lasers in medical science 14 (1999), S. 244-246 
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  • 79
    ISSN: 1435-604X
    Keywords: Keywords: Diffuser; Emission profile; Fluorescence imaging; Interstitial laser photocoagulation; Photodynamic therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Physics , Technology
    Notes: Abstract . Cylindrical light diffusers are commercially available for clinical applications such as photodynamic therapy (PDT) and interstitial laser photocoagulation (ILP). A fluorescence imaging technique has been used to quantify the light distribution produced by each of six different diffuser fibres. The light distribution produced by each device was found to depend on the distance the light propagated in the fluorescent dye solution. At a distance of 1 mm from the diffuser midline, the measured profiles were found to be consistent with published results obtained in air at a similar distance. The three devices intended for PDT utilised scattering particles and reflectors in their construction. The profiles produced by these applicators revealed peaks that were attributed to the reflectors located at their distal tips. By comparison, the two etched ILP fibres displayed either a strong modulation in the profile due to non-uniform etching or a predominant forward peak associated with the conical shape of the tip. We conclude that it is important to take into account the forward-directed light emitted by the diffusers when considering clinical applications using these devices.
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    Lasers in medical science 14 (1999), S. 297-306 
    ISSN: 1435-604X
    Keywords: Keywords: Bioheat transfer equation; ILP; In vivo; LITT; Photocoagulation; Rate kinetics; Temperature distribution; Thermal lesion size; Thermotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Physics , Technology
    Notes: Abstract . An investigation of the temperature response and growth of thermal lesions resulting from in vivo, interstitial laser photocoagulation at long exposures was conducted to assess extended lesion growth characteristics and test the applicability of first order unimolecular rate kinetics (Arrhenius theory) to thermal lesion growth. Irradiations were performed in vivo in rabbit muscle using a continuous 805 nm diode laser source operating at 1.0 W coupled to an optical fibre with a precharred tip (i.e. point heat source). Temperature responses were measured using a linear array of five microthermocouples. Each temperature–time profile was fitted to a solution of the Weinbaum–Jiji bioheat transfer equation (W–J BHTE). Lesions were resected 48 h post-irradiation and the necrosis boundaries were determined histologically. Numerical integration of the Arrhenius damage integral using temperature–time data at the lesion boundary produced corresponding pairs of activation energy and pre-exponential factor (E a, α) consistent with reported values for various other end-points and tissue types. Lesion radii were 6.0±0.6, 8.7±0.4 and 9.7±0.5 mm for 10, 20 and 30 min irradiations respectively. Thermal lesion growth predicted from Arrhenius theory was consistent with experimental results and is non-asymptotic by 30 min. Thermal parameters generally assumed to be constant when solving the W–J BHTE were found to vary with radial distance from the source, presumably due to a temperature dependence.
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    Bulletin of engineering geology and the environment 57 (1999), S. 301-310 
    ISSN: 1435-9537
    Keywords: Mots clés Glissement de terrain ; Caractéristiques mécaniques ; Essais in-situ ; Néotectonique ; Constantine ; Key words Landslides ; Geotechnical characteristics ; In situ tests ; Neotectonic ; Constantine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Description / Table of Contents: Abstract  The article can be conveniently divided into two parts. The first part of the paper describes certain forms of landslides observed in the urban area of Constantine which indicate neotectonic activity. The detailed surveys of present and fossil ground movements showed the geological formations to be of Mio-Pliocene age and to consist of two lithological groups: clayey marls and conglomerates. The slope terrain and potential for instability varies considerably with the two lithologies. The clayey-marl group contain local sand and gravel horizons of varying thickness. These water-bearing levels are confined and hence if the natural egress points become blocked, the increased water pressure within the material causes instability. Landslides rarely occur within the conglomerates, even when they are at quite steep angles. However, where conglomerates are found interbedded with the marly sediments, significant landslides can take place, The location and geology of the El Menia (1), Bardo (2), Aouinet El Foul (3) and Oued zied (4) slides are presented. The second part of the paper presents some geotechnical characteristics of the unstable geological formations, obtained by in situ and laboratory testing and the correlations drawn between them.
    Notes: Résumé L'étude présentée se compose de deux parties. La première explique certaines formes de glissement de terrain observées dans l'agglomération de Constantine comme témoins d'une activité néotectonique. La seconde partie présente quelques caractéristiques géotechniques, des formations géologiques instables, obtenues par différents moyens: les essais de laboratoire, les essais in-situ, les corrélations.
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    Bulletin of engineering geology and the environment 57 (1999), S. 285-293 
    ISSN: 1435-9537
    Keywords: Mots clés Ravins ; Lithologie ; SIG ; Densité des ravins ; Susceptibilité ; Terrassement ; Key words Gullies ; Lithology ; GIS ; Gull density ; Susceptibility ; Terracing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Description / Table of Contents: Abstract  Gully development in Central Tunisia is contributing to the fast decrease of agricultural land. Fieldwork has shown the most salient feature influencing the gully morphology and density is the surficial geology. A network of dense V-shaped gullies has developed on the gypsum clay of Lutetian-Priabonian age while deep and narrow U-shaped gullies form in the semi-consolidated fine sandstone of early Oligocene age. The research reported studied the relationship between the geological materials and the growth rate of gullies in the 1500-ha basin of the Oued Maiez, Central Tunisia. An accurate superficial geology map with interpreted geological cross sections has been constructed at a scale of 1 : 12,500. Eight rock units were identified within the drainage basin. The 1963 and 1989 aerial photographs were enlarged to the 1 : 12,500 scale and the gully network indicated in the photographs superimposed on the geological maps. The gully lengths and areas for each geological unit were numerically determined using the Geographic Information System (GIS) Arc/info software. The gully density was found to vary depending on the geological formation. From the 1989 aerial photograph it was 101 m/ha for the Cherichera formation (early and middle Oligocene) while for the unit 2 formation (Lutetian-Priabonian age) it was 285 m/ha. Substantial differences in gully density between 1963 and 1989 were noted. During this 27-year period the growth rate of gullies was found to vary depending on the geological units. The highest growth rate of 100% was found in the semi-consolidated fine sandstone of the Cherichera formation whereas in the unit 8 formation (coarse sands and conglomerates of Quaternary age) it was only 45%. Gully geometry was described for each rock type and it was found that the width/depth ratio also varies according to rock type. In a 64 ha terraced area in the Oued Maiez basin, terracing in 1985 reduced gully density by as much as 27%.
    Notes: Résumé L'érosion ravinante réduit de plus en plus les terres cultivables en Tunisie Centrale en les transformant en badland. Le développement des ravins est variable dans l'espace et dans le temps suite à la variabilité des paramètres physiques et naturels qui régissent l'accroissement des ravins. Nous nous sommes proposés dans cette recherche d'étudier l'effet des formations lithologiques sur le développement des ravins dans le bassin versant de 1500 ha d'Oued Maiez situé en Tunisie Centrale. Les cartes du réseau hydrographique de 1963 et 1989 ont étéétablies à partir des photographies aériennes au 1/12,500 non redressées. La prospection du terrain nous a permis de constater que la nature lithologique des différentes unités géologiques et superficielles identifiées comme relativement homogènes dans le bassin versant est un facteur déterminant dans le développement des ravins. Ainsi, les argiles gypseuses de la formation Chérichéra (Lutétien-Priabonien) présentent un chevelu de ravins dense alors que les sables fins de l'Oligocène inférieur sont incisés par des ravins en forme de gorges étroites dont la profondeur dépasse souvent les 5 m (Fig. 7). Nous avons alors établi un levé cartographique détaillé au 1/12,500 de ces différentes unités qui sont au nombre de 8. La détermination de la densité du ravinement, définie comme étant le rapport de la longueur des ravins dans une unité lithologique sur sa superficie, a été faite par la numérisation des cartes du réseau hydrographique et géologique et l'extraction à l'aide du système d'information géographique (SIG) Arc/info des ravins inclus dans chacune de ces unités (Figs. 9, 10). Il ressort de cette quantification que, dans les unités dont la superficie varie entre 33.96 ha et 416.86 ha, la densité du ravinement varie entre 101 m/ha et 285 m/ha en 1989 (Tableau 2). La plus faible densité se trouve dans la formation Chérichéra datée de l'Oligocène inférieur à moyen et constituée par la superposition de plusieurs séquences élémentaires d'argile feuilletée verte, de silt et de grès roux coquillier à ciment calcaire. La plus forte densité se trouve dans l'unité 2 datée du Lutétien supérieur- Priabonien et composée d'argiles verdâtres à violacées riches en gypses lamellaires. L'étude diachronique de la densité du ravinement par unité lithologique entre 1963 et 1989 a montré des taux d'évolution variant entre 45% et 100% en 27 ans (Tableau 2). Cela a permis d'effectuer un classement de la susceptibilitéà l'érosion de ces différentes unités. Les travaux de terrassement par des banquettes en 1985 dans une zone couvrant 64 ha de terres agricoles ravinées (Fig. 11) ont permis de réduire la densité des ravins de 27%.
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    Bulletin of engineering geology and the environment 57 (1999), S. 319-320 
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    Bulletin of engineering geology and the environment 57 (1999), S. 321-321 
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    Bulletin of engineering geology and the environment 57 (1999), S. 311-318 
    ISSN: 1435-9537
    Keywords: Mots clés Sédimentation ; Consolidation ; Vase ; Modélisation ; Key words Sedimentation ; Consolidation ; Mud ; Modelling
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Description / Table of Contents: Abstract  Nowadays numerical models tend to replace physical models for the study of sediment transport processes in fluvial or marine environments. The variability of both the materials and the environments make the processes complex in areas of major economic importance such as estuaries. The representativeness of current models depends much on the evaluation of the material which is deposited and/or re-suspended, hence the modelling of the deposit and consolidation phenomena. The paper proposes a unidimensional analysis of the sedimentation-consolidation process based on a continuous action and taking account of the complexity of the sedimentary materials. The distinction between sedimentation (the fall of isolated grains in a fluid medium) and consolidation (compression of a solid deposit by evacuation of pore water) is difficult to determine in the case of muds. In muds, particles frequently interact (for example in flocculation and deflocculation) although the grains remain separated by a film of water at a microscopic scale. In the 1980s and 1990s, several authors attempted to unify the two phenomena. This paper reviews the most significant works on sedimentation and consolidation and discusses their limitations, noting that there is always a boundary between the two processes. The model proposed in this paper assumes a continuity of the sedimentation-consolidation process which remains compatible with previous theories. It is based on wide assumptions, postulating the effective stress can be time dependent and the infiltration velocity is not necessarily governed by Darcy's law. A system of equations is derived which are valid for a polyphasic medium (solid, liquid, gas) and where the solid phase can be composed of isolated grains and aggregates. State equations, equations of mass conservation and equations of mechanical equilibrium are completed by laws derived from the experimental approaches described in this paper or from those of other authors. The model allows the introduction of various shapes of constitutive laws, incorporating time in the effective stress function (taking account of creep phenomena) and a filtration velocity which does not follow Darcy's law (notably for the very low hydraulic gradients). This new model is applicable to a great number of sedimentation and/or consolidation cases, e.g. – Under water sedimentation-consolidation cyclic   load (swell, tide, etc.). – Consolidation of mud in ground deposits. – Consolidation of soft clay layers. The model has been validated by means of the sedimentation-consolidation simulation tests as undertaken by Been (1981). Despite the use of simple constitutive laws, the model gives a theoretical evolution of density profiles which is very similar to the experimental one for the same initial conditions. This model of the transition between sedimentation and consolidation has a wide field of application, including civil engineering, medicine, the food industry, chemical engineering and ecology.
    Notes: Résumé L'étude de la sédimentation et de la consolidation des sédiments cohésifs présente un grand intérêt scientifique par son aspect interdisciplinaire, à la frontière hydraulique-géotechnique et en raison de l'importance de ses applications à la gestion des zones cotières. Nous proposons d'associer les points de vue hydraulique et géotechnique en vue d'établir un modèle continu du processus de sédimentation-consolidation basé sur les équations de conservation de deux phases compressibles. Ce modèle, général et évolutif, permet d'envisager la prise en compte de phénomènes négligés jusqu'alors: fluage, floculation, écoulements non-darciens, ... Il constitue donc un élément fondamental pour une modélisation globale et précise de la dynamique sédimentaire en estuaire.
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    Bulletin of engineering geology and the environment 57 (1999), S. 325-326 
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    Bulletin of engineering geology and the environment 57 (1999), S. 327-336 
    ISSN: 1435-9537
    Keywords: Mots clefs Stabilité de talus ; Mine ; Lignite ; Seisme ; Turquie ; Key words Slope stability ; Mine ; Lignite ; Seism ; Turkey
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Description / Table of Contents: Abstract  A slope stability analysis of the Afsin-Elbistan lignite mine in Turkey was prepared taking into account the seismic environment of the mine. In a first paper, Kiliç, du Mouza and Arnould (1997) presented the general conditions of the pit – its geology, hydrogeology and soil mechanical properties – together with computations of safety coefficients using a static approach such as those developed by Bishop, Carter and Sarma. This paper presents a pseudostatic approach and compares it with that used by Kiliç and al (1997). This method of analysis was considered realistic as the mine is located in a seismic area. Having considered the seismic context, a regional seismic coefficient k was derived from the Bath method. This was then introduced into the safety coefficient computations, according to each model used. This coefficient, applied to the weight of the soil likely to move, provides a value of the elastic strength equivalent to the stresses in the dynamic state. As in the static approach, the results highlight the main influence of the hydrogeological and geometrical slope conditions, for each of which several assumptions were tested. Solution I corresponds to the slope geometry proposed during the mine planning stage which was adopted at the commencement of the exploitation. Three important landslides occurred resulting in a change in the slope geometry and leading to the choice of Solution II. Computations made during this work have shown that for this configuration the slopes could be unstable in a saturated state. For this reason Solution III was designed, reducing the slope angles. The variation in the safety coefficients between the static and pseudostatic approach is clearly evident. The difference between the slope geometry assumed in Solution II and that proposed to prevent any slope instability (Solution III) is some 20%. The latter proved to be the only geometry which could be considered stable whatever the hydrogeological conditions.
    Notes: Résumé Le but de ce travail a été d'effectuer une analyse de la stabilité des talus de la mine d'Afsin-Elbistan (Turquie) en prenant en compte le contexte sismique de la mine par une approche pseudo-statique qui a été développée en complément de l'étude statique présentée dans un article précédent. Cette analyse s'impose dans ce cas car la mine est située dans une région sismique. Les calculs des coefficients de sécurité ont été effectués en mode pseudo-statique en utilisant les méthodes de Bishop, de Carter et de Sarma. Comme dans l'approche statique, ces résultats montrent l'influence primordiale des conditions hydrogéologiques et de la géométrie choisie pour les talus de la fosse. Ils mettent aussi clairement en évidence la variation des coefficients de sécurité entre l'approche statique et pseudo-statique.
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    Bulletin of engineering geology and the environment 57 (1999), S. 353-358 
    ISSN: 1435-9537
    Keywords: Key words Sand ; Chemical grout ; Stress ratio ; Single-stage creep ; Multi-stage creep
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Description / Table of Contents: Résumé Cet article présente les résultats d'une étude sur le comportement mécanique en fonction du temps (fluage) d'échantillons de sables de Leighton Buzzard injectés par un produit silicaté (silicate-Hardener 600B), soumis à un chargement progressif discontinu. Des essais de fluage, avec ou sans contrainte latérale, en plusieurs étapes de chargement ont été réalisés sur des échantillons de sables injectés par différents produits silicatés couvrant la gamme généralement utilisée dans la pratique professionelle. Les résultats de laboratoire ont montré que les déformations de fluage s'accroissent avec l'accroissement du rapport des contraintes entrainant une augmentation du taux de déformation qui conduit en définitive à une rupture par fluage (rupture totale). Cependant, un accroissement du rapport des contraintes ne modifie pas la relation linéaire entre le logarithme du taux de déformation et le logarithme du temps, suggérant que la relation phénoménologique à trois paramètres de Singh et Mitchell (1968) peut convenir pour décrire le comportement en fluage, avec plusieurs étapes de chargement, de sables injectés par un produit silicaté (silicate-Hardener 600B).
    Notes: Abstract  This paper describes the results of a study on the stress-strain time dependent (creep) behaviour of silicate-Hardener 600B grouted Leighton Buzzard sand specimens when subjected to incremental loading at certain time intervals. Unconfined and confined multi-stage creep tests were conducted on sand specimens injected with different silicate content grouts which cover the range generally used in engineering practice. The laboratory results showed that creep movements increase with the increase in stress ratio causing a rise in strain rate which ultimately leads to creep rupture (complete failure). However, an increase in the stress ratio does not affect the linear relationship between logarithm of strain rate and the logarithm of time suggesting that the three parameter phenomenological relationship of Singh and Mitchell (1968) may be suitable to describe the multi-stage creep behaviour of silicate-Hardener 600B grouted sand.
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    Bulletin of engineering geology and the environment 57 (1999), S. 343-352 
    ISSN: 1435-9537
    Keywords: Key words Natural aggregates ; Wadi aggregate ; Concrete ; Engineering properties ; Makkah ; Saudi Arabia ; Mots clés Granulats ; Oued ; Propriétés ; Béton
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Description / Table of Contents: Résumé Des agrégats naturels grossiers et fins accumulés le long de six oueds sélectionnés dans la région de Makkah ont été analysés d'un point de vue qualitatif et quantitatif. Les six oueds ont pour noms Numan, Al-Yamanyah, Al-Shamyah, Hwarah, Alaf et Faydah. Plus de 440 échantillons ont été prélevés et leurs propriétés physiques, mécaniques et chimiques déterminées. Des études pétrographiques sur des échantillons de graviers ont été réalisées pour caractériser les types de granulats. Les résultats ont été comparés aux spécifications ASTM et au British Standard. Les granulats étaient généralement dans les limites acceptables pour des granulats pour béton, bien que des valeurs relativement élevées en chlorures, sulfates et sels totaux dissous dans les granulats fins des oueds Alaf, Hwarah et Faydah, aient été trouvées. Neuf échantillons de granulats fins issus de dépôts des cours supérieur, moyen et inférieur de ces oueds salins ont été percolés par des eaux distillées ; après quoi, les granulats présentaient des caractéristiques acceptables pour des bétons de structures. Des indications sur les substances susceptibles d'être la cause d'alcali-réaction à partir des granulats grossiers de l'oued Wadi Faydah ont été données. L'étude a démontré l'existence de réserves de 12,5 millions de m3 de granulats grossiers et de 23 millions de m3 de granulats fins.
    Notes: Abstract  Natural coarse and fine aggregates which accumulated along six selected wadis in the region of Makkah were assessed both qualitatively and quantitatively. The six wadis were Numan, Al-Yamanyah, Al-Shamyah, Hwarah, Alaf and Faydah. More than 440 aggregate samples were collected and their physical, mechanical and chemical properties determined. Petrographic studies on the gravel samples were undertaken to characterise the aggregate types. The results were compared with ASTM and British Standard specifications. The aggregates were generally within the acceptable limits for use in concrete although there were the relatively high values of chloride, sulphate and total dissolved salts in the fine aggregates in Wadis Alaf, Hwarah and Faydah. Nine fine aggregate samples representing upstream, midstream and downstream deposits from these saline wadis were washed in distilled waters after which the aggregates were within the acceptable limits for structural concrete. There were indications of material which could cause alkali-silica in the coarse aggregate at Wadi Faydah. The study proved reserves of 12.5 million m3 of coarse aggregate and 23 million m3 of fine aggregate.
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    Bulletin of engineering geology and the environment 57 (1999), S. 397-398 
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    Bulletin of engineering geology and the environment 57 (1999), S. 369-376 
    ISSN: 1435-9537
    Keywords: Mots clés Niveau de la mer ; Dragage ; Marée ; Surcote de tempête ; Estuaire de la Loire ; France ; Key words Sea level ; Dredging ; Tide ; Storm surge ; Loire estuary ; France
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Description / Table of Contents: Abstract  The present study compares the tide measurements on the left and right banks of the mouth of the river Loire (France) which flows into the Atlantic Ocean and two others points on the French Brittany coast (Fig. 1, 2), for the last twentyfive years. In order to simplify the location of the sites, the points have been numbered from the north to the south as follows: • Point 1 : Le Conquet • Point 2: Port Tudy, île de Groix • Point 3: St.-Nazaire • Point 4: Pointe de St.-Gildas The observed tide levels in the estuary of the river Loire show important changes since 1903 (Fig. 3). These modifications can be linked to the dredging works in the navigation channel between Paimboeuf and Nantes (55 km upstream) where the bottom level has been excavated from –2.50 m to –3.00 m in 1929 and to –5.50 m in 1969. Whereas the chart datum (hydrographic zero reading), which in France corresponds to the lowest possible seas for safe navigation, had been set at the end of the last century at 3.03 m under the terrestrial chart datum, on January 1st 1996, the SHOM, Naval Hydrographic and Oceanographic Service, indicated that on all the nautical documents it publishes this chart datum was now being set at 3.43 m under the terrestrial chart datum for the right bank of the mouth of the estuary (corresponding to the northern side of the estuary) while the one for the left bank, although only 15 km away, remained unchanged. The statistical study of surges for a period of twenty five years (1965–90) on both sides of the external estuary shows that the surges are significantly greater on the north-eastern side. It also highlights the incoherence of certain results. The study of level readings on 3 500 high and low tides effected by 4 tide gauges spread out along 300 km of coastline highlighted that a single badly zeroed tide gauge could lead to false results with regards to the average tide level at point 3. The work shows that this discrepancy is neither due to the blocking of fresh river water nor to a set of compartment faults but to the displacement and dredging of the channel along the right bank of the mouth of the estuary. The storm surges have also been studied between 1985 and 1990 using a dynamic model where surge levels depend on the duration of the meteorological disturbances. In this model the surge associated with a stationary meteorology S∞ depends on the wind (velocity and direction) and the atmospheric pressure. The theoretical law for the surge due to atmospheric pressure is valid in the 4 points studied; for each hectoPascal of lowering of barometric pressure, the sea level increase is 1 cm. For a wind of constant velocity and direction, the model shows that the surges are greater at points 3 and 4 than at points 1 and 2. This fact can be explained by the local morphology of the external part of the estuary; it also gives an explanation for the coastal erosion of this area. This model confirms that the reduction of the extreme low water level observed at point 3 is a local disturbance. In fact, the increase of the mean sea level is approximately 0.10 m per century at points 1 and 2 as in Brest harbour where level measurements have been undertaken since 1808. In contrast, this level appears to be stable at the two points situated on the estuary while the amplitude of the tide increases. This phenomenon is better marked at point 3 in the north of the estuary. Finally, this study shows that the installation of a mobile dam in the Loire estuary (similar to the one existing in the Thames estuary) would permit regulation of the upper water levels above the dam although the amplitude of the tide could be enhanced downstream of the dam.
    Notes: Résumé Des mesures des niveaux de basses mers réalisées par les autorités portuaires dans l'estuaire de la Loire montrent qu'entre 1969 et 1993 ce niveau est descendu d'une façon significative. Ceci s'explique par les dragages récents dans le chenal externe de l'estuaire qui ont modifié la propagation de la marée dans ce site, ce qui a conduit à une correction officielle de –0,40 m pour le zéro des cotes marines. Afin d'expliquer ce phénomène, les niveaux extrêmes de la marée ont été analysés en quatre sites de la côte bretonne occidentale entre 1965 et 1990. L'analyse statistique des données montre une nette amplification des surcotes dans la partie nord-est de l'embouchure de l'estuaire qui contribue à une érosion de ce site. L'étude phénoménologique des surcotes et des vents de 1985 à 1990 sur les deux rives de la Loire montre que le niveau moyen de la mer y reste stable.
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    Bulletin of engineering geology and the environment 58 (1999), S. 9-19 
    ISSN: 1435-9537
    Keywords: Key words Rainfall ; Landslides ; Ethiopia ; Blue Nile ; Mots clés Pluie ; Glissements de terrain ; Éthiopie ; Nil Bleu
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Description / Table of Contents: Résumé Dans les hautes terres densément peuplées de l'Éthiopie, où l'altitude dépasse 1750 m, l'augmentation du nombre et de la taille des glissements de terrain pendant les 30 dernières années préoccupe gravement la société. De 1993 à 1998, 300 personnes ont trouvé la mort, plus de 200 maisons ont été détruites, 100 km de route ont été endommagés, et plus de 500 ha de terres ont été dévastés. L'article décrit les relations existant entre les pluies et les mécanismes de glissements de terrain. Une formule est proposée pour aider à estimer les problèmes d'instabilité. Un facteur Lf, principalement déterminéà partir du rapport entre la hauteur d'eau cumulée lors de l'événement pluvieux et le module pluviométrique annuel, conduit à une probabilité d'occurrence de rupture. Il est montré que des fissures et des signes indicateurs de mouvements sont observés quand Lf se situe entre 15 et 30%, tandis que des valeurs supérieures à 30% indiquent une probabilité d'occurrence beaucoup plus grande de glissements de terrain.
    Notes: Abstract  In the densely populated highland area of Ethiopia, where altitudes exceed 1750 m, the increase in the number and size of landslides during the last 30 years is causing considerable concern among the society. From 1993 to 1998 alone, about 300 lives have been lost, more than 200 houses demolished, greater than 100 km of road damaged and in excess of 500 ha of land devastated. The paper discusses the relation between the mechanism of landslides and rainfall. A formula is suggested which could help in assessing the problems of instability. An Lf factor, determined mainly from the ratio between the cumulative precipitation and the mean annual rainfall, is proposed to indicate the likelihood of occurrence of failure. It is shown that cracks and signs of slope movement are observed when Lf is in the range of 15–30%, while values exceeding 30% indicate a much greater probability of landslide occurrence.
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    Bulletin of engineering geology and the environment 58 (1999), S. 21-44 
    ISSN: 1435-9537
    Keywords: Keywords Landslides ; Hazard ; Risk Assessment ; Neural Networks ; G.I.S ; Mots clés glissement de terrain ; aléa ; évaluation du risque ; réseaux neuronaux ; S.I.G.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Description / Table of Contents: Résumé Cet article traite de plusieurs aspects de l'évaluation de l'aléa et du risque de glissement de terrain. Ces dernières années, l'intérêt pour ce sujet a grandement augmenté et de nombreux articles techniques s'y référant ont été publiés. Cet article présente un bilan résumé et une classification des principales approches qui ont été développées de par le monde. La première étape consiste à distinguer les méthodes qualitatives et quantitatives. Le premier groupe est basé principalement sur l'expérience régionale d'experts, avec une notion de prédisposition aux glissements déterminée directement sur le terrain ou par combinaison de différentes cartes d'indices. Les approches du second groupe sont théoriquement plus rigoureuses. Il est possible de différencier des analyses statistiques (bivariées ou multivariées) et des méthodes déterministes qui font intervenir l'étude de pentes ou de sites particuliers, basée sur des modèles géomécaniques. De telles analyses peuvent être déterministes ou probabilistes. Parmi les méthodes quantitatives présentées, on trouve l'approche par les réseaux neuronaux qui n'a été que récemment appliquée à des problèmes de géologie de l'ingénieur. Enfin, plusieurs considérations relatives au concept de risque acceptable et de gestion du risque sont présentées.
    Notes: Abstract This paper deals with several aspects of the assessment of hazard and risk of landsliding. In recent years the interest in this topic has increased greatly and there are many technical papers dealing with this subject in the literature. This article presents a summary review and a classification of the main approaches that have been developed world-wide. The first step is the subdivision between qualitative and quantitative methods. The first group is mainly based on the site-specific experience of experts with the susceptibility/hazard determined directly in the field or by combining different index maps. The approaches of the second group are formally more rigorous. It is possible to distinguish between statistical analyses (bivariate or multivariate) and deterministic methods that involve the analysis of specific sites or slopes based on geo-engineering models. Such analyses can be deterministic or probabilistic. Among the quantitative methods discussed is the Neural Networks approach which has only recently been applied to engineering geology problems. Finally several considerations concerning the concept of acceptable risk and risk management are presented.
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    Bulletin of engineering geology and the environment 58 (1999), S. 45-59 
    ISSN: 1435-9537
    Keywords: Mots clés Tunnel ; Alpes ; Contraintes in situ ; Mesures de contraintes ; Méthode HTPF ; Modélisation ; Key words Tunnel ; Alps ; In-situ stresses ; Stress measurements ; HTPF method ; Modelling
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Description / Table of Contents: Abstract  The 52 km running tunnel of the proposed Lyon–Turin railway link will be excavated through different geological formations across the Franco-Italian Alps. The overburden of most of the route is greater than 1000 m, and it reaches 2500 m in the Ambin Massif, a regular micaschistic dome. As part of the reconnaissance program for this project, stress measurements using the HTPF (Hydraulic Testing on Pre-existing Fractures) method have been carried out in 13 deep boreholes, which provides a unique opportunity to better understand the regional stress field. After a presentation of the HTPF method and of its possible interpretation methods, the paper presents and discusses the results obtained. The influences of topography and tectonics are highlighted with the support of numerical modelling with the Finite Difference Method (FLAC code). Despite a great scatter of information on stress values and directions, three main stress regimes can be distinguished in three different geological-topographical contexts. The first one is found near the Arc valley, which is the main topographic feature in the area: the vertical stresses are greater than the weight of overburden and the horizontal stresses are highly anisotropic, σh being approximately perpendicular to the valley. This suggests a strong topographic influence of the Arc valley, especially for those measurements closest to its axis. Two other regimes have been encountered in the Ambin Massif. On the one hand, in the heart of the massif, under two small valleys, horizontal stresses are anisotropic with σh parallel and σh perpendicular to the valleys; but curiously vertical stresses are nearly 20% lower than the weight of overburden and are in both cases the minor principal stresses. On the other hand, under its Italian border and in a slope situation, the measured states of stress are those classically obtained in soils: vertical stresses are equal to the weight of overburden and horizontal stresses are nearly isotropic, equal to the half of the vertical ones. In order to better understand these measurements and their relation to the regional state of stress, a series of numerical calculations of increasing complexity were undertaken. They all take into consideration the effects of both the simplified topography and, in a parametrical manner, the tectonic stresses. The results are consistent with most of the global trends presented above, and particularly for the first and third stress regimes. For the second one, however, in the heart of the Ambin Massif, modelling gives only a first qualitative explanation for the low measured vertical stresses.
    Notes: Résumé Dans le cadre de la conception d'un futur grand tunnel à travers les Alpes, des mesures de contraintes naturelles ont été faites dans 13 forages profonds, dans des contextes géologiques et topographiques variés. L'article en propose une analyse critique en insistant sur l'influence des méthodes d'interprétation employées, et s'appuie pour les interpréter sur des modélisations simplifiées prenant en compte la topographie et la tectonique. Malgré la dispersion des résultats, trois grands types d'états de contraintes se dégagent. A proximité de la vallée de l'Arc, les contraintes horizontales sont fortement anisotropes, orientées suivant la vallée et les contraintes verticales sont fortes, ce qui traduit un effet topographique classique. Sous deux vallons du massif d'Ambin, les contraintes horizontales sont anisotropes et supérieures aux verticales. Enfin, sous la retombée orientale de ce massif, on trouve plutôt un état de contraintes de "type K0". Tous ces résultats sont en bonne concordance avec les modélisations présentées, à l'exception des faibles contraintes verticales du massif d'Ambin.
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    Bulletin of engineering geology and the environment 58 (1999), S. 87-88 
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    Stochastic environmental research and risk assessment 13 (1999), S. 1-26 
    ISSN: 1436-3259
    Keywords: Key words: Spatiotemporal ; stochastic ; mapping ; Bayes ; entropy ; computational approach ; physical knowledge bases ; epistemology.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Architecture, Civil Engineering, Surveying , Energy, Environment Protection, Nuclear Power Engineering , Geography , Geosciences
    Notes: Abstract This paper is concerned with a computational formulation of the Bayesian maximum entropy (BME) mapping method, which can handle rigorously and efficiently spatiotemporal applications of considerable practical importance. BME is a method of modern geostatistics that can integrate and process physical knowledge that belongs to two major bases: general knowledge (i.e., obtained from general principles and laws, summary statistics and background information), and specificatory knowledge (i.e., obtained through experience with the specific situation). BME allows considerable flexibility regarding the choice of an appropriate spatiotemporal map, offers a complete assessment of the mapping uncertainty and contributes to the scientific understanding of the underlying natural phenomenon. Valuable insight is gained by studying a spatiotemporal data set representing water-level elevations at the Equus Beds aquifer (Kansas). Numerical results show that, as was expected in theory, classical geostatistics analysis is obtained as a special case of the considerably more general BME approach. Moreover, modern geostatistical analysis in terms of BME offers more accurate and informative results in practice, by incorporating various sources of physical knowledge that cannot be processed by the classical methods.
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    Stochastic environmental research and risk assessment 13 (1999), S. 27-47 
    ISSN: 1436-3259
    Source: Springer Online Journal Archives 1860-2000
    Topics: Architecture, Civil Engineering, Surveying , Energy, Environment Protection, Nuclear Power Engineering , Geography , Geosciences
    Notes: Abstract Stochastic environmental risk assessment considers the effects of numerous biological, chemical, physical, behavioral and physiological processes that involve elements of uncertainty and variability. A methodology for predicting health risks to individuals from contaminated groundwater is presented that incorporates the elements of uncertainty and variability in geological heterogeneity, physiological exposure parameters, and in cancer potency. An idealized groundwater basin is used to perform a parametric sensitivity study to assess the relative impact of (a) geologic uncertainty, (b) behavioral and physiological variability in human exposure and (c) uncertainty in cancer potency on the prediction of increased cancer risk to individuals in a population exposed to contaminants in household water supplied from groundwater. A two-dimensional distribution (or surface) of human health risk was generated as a result of the simulations. Cuts in this surface (fractiles of variability and percentiles of uncertainty) are then used as a measure of relative importance of various model components on total uncertainty and variability. A case study for perchloroethylene or PCE, shows that uncertainty and variability in hydraulic conductivity play an important role in predicting human health risk that is on the same order of influence as uncertainty of cancer potency.
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    Stochastic environmental research and risk assessment 13 (1999), S. 66-84 
    ISSN: 1436-3259
    Source: Springer Online Journal Archives 1860-2000
    Topics: Architecture, Civil Engineering, Surveying , Energy, Environment Protection, Nuclear Power Engineering , Geography , Geosciences
    Notes: Abstract Velocity variability at scales smaller than the size of a solute plume enhances the rate of spreading of the plume around its center of mass. Macroscopically, the rate of spreading can be quantified through macrodispersion coefficients, the determination of which has been the subject of stochastic theories. This work compares the results of a volume-averaging approach with those of the advection dominated large-time small-perturbation theory of Dagan [1982] and Gelhar and Axness [1983]. Consider transport of an ideal tracer in a porous medium with deterministic periodic velocity. Using the Taylor-Aris-Brenner method of moments, it has been previously demonstrated [Kitanidis, 1992] that when the plume spreads over an area much larger than the period, the volume-averaged concentration satisfies the advection-dispersion equation with constant coefficients that can be computed. Here, the volume-averaging analysis is extended to the case of stationary random velocities. Additionally, a perturbation method is applied to obtain explicit solutions for small-fluctuation cases, and the results are compared with those of the stochastic macrodispersion theory. It is shown that the method of moments, which uses spatial averaging, for sufficiently large volumes of averaging yields the same result as the stochastic theory, which is based on ensemble averaging. The result is of theoretical but also practical significance because the volume-averaging approach provides a potentially efficient way to compute macrodispersion coefficients. The method is applied to a simplified representation of the Borden aquifer.
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    Stochastic environmental research and risk assessment 13 (1999), S. 85-99 
    ISSN: 1436-3259
    Keywords: Key words: Hydraulic diffusivity ; groundwater ; spectral analysis ; stochastic boundaries.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Architecture, Civil Engineering, Surveying , Energy, Environment Protection, Nuclear Power Engineering , Geography , Geosciences
    Notes: Abstract: This study uses the cyclical frequency to develop the mathematical relationship between hydraulic diffusivity and spectral density functions calculated from groundwater level variation. Such relationship can be applied to (1) unsteady state, one-dimensional confined aquifer with time-dependent water level on both end boundaries, and (2) linearized unconfined aquifer with or without vertical recharge. The spectral density functions of groundwater fluctuations are largely affected by the spectral density functions obtained from time-dependent end boundaries and their cross-spectral density functions. Hydraulic diffusivity of an aquifer can be solved by type-curve matching technique at a specified frequency band under the conditions of (1) confined aquifer having equal time-dependent boundaries on both ends, (2) unconfined aquifer having equal time-dependent boundaries on both ends with surface recharge, and (3) unconfined aquifer subjected to surface recharge but neglecting the water table fluctuations on both end boundaries.
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    Stochastic environmental research and risk assessment 13 (1999), S. 113-130 
    ISSN: 1436-3259
    Keywords: Key words: Climatology ; meso-scale convective systems ; classification ; anisotropy ; intermittency ; ergodicity ; upscaling ; level sets.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Architecture, Civil Engineering, Surveying , Energy, Environment Protection, Nuclear Power Engineering , Geography , Geosciences
    Notes: Abstract: The meta-Gaussian model is fitted to a set of 258 sahelian rainfields. The hypotheses underlying this model are discussed with a special emphasis on its ergodic properties, the scale of the phenomenon and the scale of observation. Then the ability of this model to reproduce some observed features, in particular upscaling properties, is checked from a distributional point of view. Finally, some simple properties of the thresholds which are linked to the area threshold method are described.
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