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  • 1
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    The Antarctic Regional GPS Network Densification: Status and Results (2016)
    In:  IAG 150 Years : Proceedings of the IAG Scientific Assembly in Postdam, Germany, 2013 | International Association of Geodesy Symposia
    Details
    Publication Date: 2020-02-12
    Type: info:eu-repo/semantics/bookPart
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    PAPER (OA)
  • 2
    Electronic Resource
    Electronic Resource
    Identification and estimation of choline derivatives by mass spectrometry (1968)
    s.l. : American Chemical Society
    Analytical chemistry 40 (1968), S. 1837-1840 
    Details
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ac60268a014
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  • 3
    Electronic Resource
    Electronic Resource
    Peripheral vascular effects of bufuralol in hypertensive and normal subjects: A comparison with propranolol and pindolol (1986)
    Springer
    European journal of clinical pharmacology 30 (1986), S. 649-652 
    Details
    ISSN: 1432-1041
    Keywords: bufuralol ; propranolol ; pindolol ; peripheral blood flow ; systemic blood pressure ; beta-adrenoceptor antagonist ; hypertension ; adverse effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In a double-blind, single oral dose, crossover study, the effects of bufuralol (60 mg) on heart rate, blood pressure, and peripheral vascular responses were compared with those of propranolol (160 mg), pindolol (10 mg), and placebo in a group of 12 healthy volunteers. All three beta-adrenoceptor antagonists reduced exercise tachycardia, but at the doses chosen the effects of bufuralol were less than those of propranolol. Forearm blood flow was reduced by propranolol and pindolol, but not by bufuralol. The antihypertensive and peripheral vascular effects of bufuralol (30–60 mg bd) were also compared with those of propranolol (40–80 mg bd) in a double-blind crossover study in 10 patients with mild hypertension. Propranolol and bufuralol produced comparable reductions in systemic blood pressure over a two-week period, but the decreases in forearm and finger blood flow were greater with propranolol. These studies suggest that bufuralol is a beta-adrenoceptor antagonist with antihypertensive properties, and that it produces less peripheral vasoconstriction than propranolol or pindolol.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00608210
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  • 4
    Electronic Resource
    Electronic Resource
    Can digoxin prescribing be improved? A comparison between intuitive and assisted dose selection (1979)
    Springer
    European journal of clinical pharmacology 16 (1979), S. 229-235 
    Details
    ISSN: 1432-1041
    Keywords: digoxin ; therapeutic range ; intuitive prescribing ; prescribing aid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary 37 patients on maintenance digoxin therapy were observed in hospital over an 8 day period. From day 1 to day 8 measurements of plasma digoxin and serum creatinine indicated that these patients were in the equilibrium state with regard to digoxin levels and renal function. Assuming a linear relationship between dose and plasma concentration, it was possible to calculate the doses which would have produced plasma concentrations of 1.5 ng/ml, and at the limits of the ‘usual therapeutic range’, 0.8 and 2.0 ng/ml. Doses obtained from six prescribing aids and those prescribed intuitively by the doctor were then compared. None of the methods used would have resulted in plasma digoxin concentrations within the ‘usual therapeutic range’ in more than 57% of the patients. The physicians' intuitive choice appeared to be better than the doses estimated from prescribing aids, in that they were correct as often as any assisted method, and when wrong tended to prescribe ‘too low’ rather than ‘too high’. The prescribing aids tended to overestimate dosage in many patients, as high as 65% with one. Plasma digoxin concentration measurement would appear to be the only way to ensure adequate therapeutic efficacy and avoid toxicity in patients receiving maintenance digoxin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00608400
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  • 5
    Electronic Resource
    Electronic Resource
    The effect of chronic captopril therapy on platelet angiotensin II receptor density and vascular responsiveness to angiotensin II infusion (1987)
    Springer
    European journal of clinical pharmacology 31 (1987), S. 525-530 
    Details
    ISSN: 1432-1041
    Keywords: angiotensin II ; captopril ; platelet receptor density ; vascular responses ; long term treatment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The density of angiotensin II (Ang II) receptors on the platelet and the vascular responsiveness to infused angiotensin II before and after two weeks of captopril therapy were examined in ten healthy male volunteers. There was a significant increase in blood flow to the forearm, but no significant changes in either the density of angiotensin II receptors or the pressor response to infused angiotensin II following captopril therapy. The study demonstrates that long term reduction of angiotensin II formation by captopril in man does not increase the responsiveness of the receptors to infused angiotensin, nor results in an „up regulation“ of the angiotensin receptors. It also provides further evidence that some of the long term vasodilator effects of captopril may be mediated by mechanisms other than inhibition of angiotensin I (Ang I) converting enzyme.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00606624
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  • 6
    Electronic Resource
    Electronic Resource
    The effect of chronic captopril therapy on adrenergic receptors, plasma noradrenaline and the vascular responses to infused noradrenaline (1987)
    Springer
    European journal of clinical pharmacology 32 (1987), S. 229-235 
    Details
    ISSN: 1432-1041
    Keywords: noradrenaline ; captopril ; adrenergic receptors ; pressor response ; healthy volunteers ; reninangiotensin system
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Adrenergic receptors (alpha2, beta2), plasma noradrenaline, heart rate and the pressor responsiveness to infused noradrenaline were examined in ten healthy male volunteers before and after 2 weeks of placebo or captopril therapy in a double blind cross-over study. No significant differences in these measurements were observed between the captopril and placebo treated groups. The study shows that in sodium replete normotensive subjects, long-term angiotensin converting enzyme inhibition does not lead to changes in adrenoceptor density. There is also no alteration in plasma noradrenaline levels nor in the pressor responsiveness to infused noradrenaline. These data suggest that the known interaction between the renin-angiotensin system and the sympathetic nervous system observed in animals is probably of little significance in man.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00607568
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  • 7
    Electronic Resource
    Electronic Resource
    A simple aid to digoxin prescribing (1987)
    Springer
    European journal of clinical pharmacology 33 (1987), S. 441-445 
    Details
    ISSN: 1432-1041
    Keywords: digoxin ; nomogram ; prescribing aid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary We have designed a simple nomogram for predicting digoxin dosage and have tested it prospectively in two consecutive studies. These were both conducted in hospital inpatients who were not already taking digoxin but who required drug therapy for atrial tachyarrhythmias and/or cardiac failure. Study I. Sixty-seven patients received digoxin according to the nomogram and 50 completed the ten day course of the study. Fortyone of these patients were eligible for the final analysis. On the tenth day of treatment, 28 patients were within the therapeutic range for plasma digoxin (0.8 to 2.0 ng·ml−1), 12 were subtherapeutic (〈0.8 ng·ml) and one was potentially toxic (〉2.0 ng·ml−1). Study II. Thirty patients completed the second study. Digoxin was prescribed according to the nomogram with the addition of a dosage correction based on the plasma digoxin level on Day 3. On the tenth day of treatment, 24 patients were within the therapeutic range, one in the subtherapeutic and 5 in the potentially toxic. This simple digoxin nomogram, with or without the Day 3 dosage correction, should prove to be a useful aid to prescribing in patients who do not require rapid digitalisation. It is particularly relevant to elderly inpatients with atrial tachyarrhythmias and/or cardiac failure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00544232
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  • 8
    Electronic Resource
    Electronic Resource
    A comparison of the haemodynamic and hormonal effects of low and conventional dose cyclopenthiazide in normal volunteers (1990)
    Springer
    European journal of clinical pharmacology 38 (1990), S. 351-357 
    Details
    ISSN: 1432-1041
    Keywords: cyclopenthiazide ; renin-angiotensin system ; extracellular fluid volume ; vascular responses
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In this study we compared low (125 μg) and conventional (500 μg) doses of cyclopenthiazide on the renin angiotensin system, plasma and extracellular fluid volumes and the pressor responsiveness to angiotensin II since we have previously shown that the two doses have the same antihypertensive effect but different effects on plasma renin activity. Following a two week placebo run-in period, 8 healthy male volunteers received 125 μg or 500 μg of cyclopenthiazide for 2 treatment periods of 4 weeks as part of a double blind, 2-part crossover study with treatment periods separated by a 4-week placebo washout phase. Measurements were made on two study days at the beginning and end of the active treatment periods. On the first day serum potassium, plasma renin activity and plasma angiotensin II levels were measured after a 1 h period of supine rest. Plasma and extracellular fluid volumes were also measured after appropriate equilibration times. The blood pressure responses to angiotensin II were assessed on day 2. The 500 μg dose of cyclopenthiazide had a greater effect than the 125 μg dose on plasma renin activity, serum potassium, angiotensin II levels and extracellular fluid volumes. Neither drug had any effect on plasma volume or the responsiveness to infused angiotensin II. Low dose cyclopenthiazide failed to increase angiotensin II levels, contract body fluid volumes or attenuate vascular reactivity in normotensive volunteers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315574
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  • 9
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of flosequinan in patients with heart failure (1996)
    Springer
    European journal of clinical pharmacology 50 (1996), S. 289-291 
    Details
    ISSN: 1432-1041
    Keywords: Key words Heart failure ; Flosequinan; pharmacokinetics ; drug toxicity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Objective: The pharmacokinetics of flosequinan were studied in a group of 18 patients with chronic cardiac failure. Results: After a single dose of 100 mg, Cmax of the parent compound (2.52 mg ⋅ l−1) was recorded at 1.4 h, and of the sulphone metabolite flosequinoxan at 21.7 h. The plasma elimination half lives of the parent compound (6.4 h) and of the metabolite (54.3 h) were prolonged compared to previous studies in normal volunteers. After repeated dose administration for 36 days, the kinetics of the parent compound and metabolite remained essentially unchanged with an expected significant accumulation of metabolite (Cmax 8.4 vs 3.21 mg ⋅ l−1). No adverse effects were observed. Conclusion: It is possible that altered drug kinetics in patients with heart failure, probably related to altered hepatic blood flow, could contribute to drug toxicity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002280050110
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  • 10
    Electronic Resource
    Electronic Resource
    The branching ratio in the F+HD reaction: An experimental and computational study (1991)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 94 (1991), S. 2749-2757 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: The dynamical stereochemistry of the reaction of hot F atoms with HD is discussed with reference to the measured branching ratio using both exact and model classical trajectory computations. It is argued that the dominant effects are due to the shift of the center of mass from the center of charge. In particular this leads to enhanced reactivity of the D end of the molecule due both to reorientation of the molecule and to the recrossing of the barrier. The observed preference for reaction at the H end is attributed to HD rotational excitation reflecting however the shape of the potential energy surface and not the longer arm of the H atom about the center of mass. Measuring the reaction cross sections for rotationally cold HD will provide a critical test of our understanding of the dynamics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.459852
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