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  • phosphorus  (73)
  • apoptosis  (52)
  • Springer  (125)
  • American Chemical Society
  • American Meteorological Society
  • 1995-1999  (125)
  • 1990-1994
  • 1955-1959
  • 1999  (125)
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  • Springer  (125)
  • American Chemical Society
  • American Meteorological Society
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  • 1995-1999  (125)
  • 1990-1994
  • 1955-1959
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  • 101
    Electronic Resource
    Electronic Resource
    Sedimentation and particulate nutrient dynamics along a coastal gradient from a fjord-like bay to the open sea (1999)
    Springer
    Hydrobiologia 393 (1999), S. 127-140 
    Details
    ISSN: 1573-5117
    Keywords: sedimentation ; carbon ; nitrogen ; phosphorus ; resuspension ; export production ; Baltic Sea
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Seasonal changes of total particulate material (TPM), particulate organic carbon (POC), nitrogen (PON) and phosphorus (PTP) concentrations in the water column, in sediment traps and on the sediment surface were studied in the SW coast of Finland, Baltic Sea, from March to November 1992. Sampling was carried out along a coastal gradient from the fjord-like, semi-enclosed Pojo Bay to the outer archipelago and open sea area. In Pojo Bay, TPM sedimentation rates were high and relatively constant, and had low organic carbon contents throughout the seasonal cycle. Resuspension was estimated to contribute 〉 90% of total sedimentation of POC and PON. Clear seasonality in sedimentation with high settling rates of primary organic material in spring, low sedimentation rates during summer and a considerable increase of resuspension during autumn was found in the outer archipelago and open sea. The C:N:P ratios of suspended, settled and sediment surface material indicated greater sedimentary loss of N (as compared to P and C) and closer coupling between pelagial and benthos in the archipelago and open sea area than in Pojo Bay. The sedimentation of P was 20–50% more effective (as compared to N and C) in Pojo Bay than elsewhere. These results indicate that the shift of planktonic nutrient limitation (from P to N limitation) is enhanced due to the more efficient sedimentation of the main limiting element along the estuarine gradient. The primary sedimentation of organic carbon (approximating export flux from the pelagic system) during the whole study period was estimated to be 30–48% of the total net primary production. This indicates that despite the differences in the salinity, nutrient dynamics and planktonic community structure along the coastal gradient, a relatively constant fraction of the annual primary production is exported from the pelagic system by sedimentation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1003539230715
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  • 102
    Electronic Resource
    Electronic Resource
    Understanding lake and catchment history as a tool for integrated lake management (1999)
    Springer
    Hydrobiologia 395-396 (1999), S. 41-60 
    Details
    ISSN: 1573-5117
    Keywords: nitrogen ; phosphorus ; non-point source ; export ; catchment modelling
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Sustainable lake management for nutrient-enriched lakes must be underpinned by an understanding of both the functioning of the lake, and the origins of changes in nutrient loading from the catchment. To date, limnologists have tended to focus on studying the impact of nutrient enrichment on the lake biota, and the dynamics of nutrient cycling between the water column, biota and sediments within the lake. Relatively less attention has been paid to understanding the specific origins of nutrient loading from the catchment and nutrient transport pathways linking the lake to its catchment. As such, when devising catchment management strategies to reduce nutrient loading on enriched lakes, assumptions have been made regarding the relative significance of non-point versus point sources in the catchment. These are not always supported by research conducted on catchment nutrient dynamics in other fields of freshwater science. Studies on nutrient enrichment in lakes need to take account of the history of catchment use and management specific to each lake in order to devise targeted and sustainable management strategies to reduce nutrient loading to enriched lakes. Here a modelling approach which allows quantification of the relative contribution of nutrients from each specific point and non-point catchment source over the course of catchment history is presented. The approach has been applied to three contrasting catchments in the U.K. for the period 1931 to present. These are the catchment of Slapton Ley in south Devon, the River Esk in Cumbria and the Deben Estuary in Suffolk. Each catchment showed marked variations in the nature and intensity of land use and management. The model output quantifies the relative importance of point source versus non-point livestock and land use sources in each of the catchments, and demonstrates the necessity for an understanding of site-specific catchment history in devising suitable management strategies for the reduction of nutrient loading on enriched lakes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1017002914903
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  • 103
    Electronic Resource
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    The importance of palaeolimnology to lake restoration (1999)
    Springer
    Hydrobiologia 395-396 (1999), S. 149-159 
    Details
    ISSN: 1573-5117
    Keywords: sediment ; diatoms ; phosphorus ; acidification ; eutrophication
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Palaeolimnology has developed rapidly over the last two decades to deal with problems of eutrophication, and acidification. This paper reveiew the techniques for coring, dating and interpreting sediments. The applications of palaeolimnology in interpreting the past through ‘transfer functions’ calculated from biological indices are reviewed. Rates of change, the causes of change, and the restoration of lakes to some predefined target are reviewed and the direction of future developments considered.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1017093418054
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  • 104
    Electronic Resource
    Electronic Resource
    The management of hypertrophic lochs: case studies in southwest Scotland (1999)
    Springer
    Hydrobiologia 395-396 (1999), S. 293-308 
    Details
    ISSN: 1573-5117
    Keywords: phosphorus ; sediments ; eutrophication ; Scotland
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract This paper considers the range of management techniques which are currently available for the remediation of eutrophic lakes, with respect to two lochs within southwest Scotland. Preliminary studies of sources of nutrients identified the need for the development of different management prescriptions for each. Such studies will ensure that the management is tailored to meet the specific needs of the site. The two lochs, Carlingwark Loch at Castle Douglas and Castle Loch at Lochmaben, both support algal blooms but have different nutrient sources. Carlingwark Loch appears to be receiving large quantities of nutrients from the surrounding catchment, whereas Castle Loch shows a net loss of nutrients over its surface inflows, indicating release from the sediments and/or input from overwintering wildfowl. In these cases, if preliminary studies had not been undertaken, the management programmes developed may not have used the most effective control measures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1017034610302
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  • 105
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    The effect of aquatic vegetation on turbidity; how important are the filter feeders? (1999)
    Springer
    Hydrobiologia 408-409 (1999), S. 307-316 
    Details
    ISSN: 1573-5117
    Keywords: macrophytes ; turbidity ; phytoplankton ; zooplankton ; nutrients ; phosphorus ; model ; grazing ; top-down control
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract A review of the literature suggests that aquatic macrophytes can enhance water clarity and reduce phytoplankton biomass through shading, reduction of nutrient availability, excretion of allelopathic substances and reduction of resuspension. In addition, vegetation fields are reported to enhance grazing on phytoplankton by providing a day-time refuge against fish predation for planktonic filter feeders such as Daphniaand by providing a suitable habitat for macrophyte associated filter feeders such as Sida crystallina, Eurycercus lamellatusand Simocephalus velutus. I use a graphical and a simple mathematical model to explore how top-down control by these grazers may interact with the effect of reduced phytoplankton production due to the other factors mentioned. The analysis suggests that grazing tends to be an all-or-none effect, driving phytoplankton to a very low biomass once a certain threshold level of grazing pressure is exceeded. This threshold level is predicted to increase with the productivity of the phytoplankton. Thus, the model suggests that, in plant beds, productivity reducing factors such as shading and reduced nutrient concentrations can pave the way for top-down control of phytoplankton even by a relatively moderate population of filter-feeders, and that phytoplankton biomass will decrease sharply beyond a critical macrophyte (or grazer) density. Indeed such a discontinuous response is observed in field experiments. Also, the idea that filter feeding cladocerans such as Daphniaplay a key role is in line with the observation that brackish lakes where Daphniadoes not thrive tend to be turbid despite the often dense weed beds.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1017011320148
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  • 106
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    Dimictic versus polymictic masurian lakes: similarities and differences in chlorophyll-nutrients–SD relationships (1999)
    Springer
    Hydrobiologia 408-409 (1999), S. 389-394 
    Details
    ISSN: 1573-5117
    Keywords: mictic type ; water transparency ; nitrogen ; phosphorus ; chlorophyll:nutrient ratio ; chlorophyll:seston ratio
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Data for comparison are from 17 dimictic and four polymictic lakes interconnected to form a system of the Great Masurian Lakes. Both summer epilimnetic total phosphorus and chlorophyll were higher in dimictic than in polymictic lakes. Chlorophyll was probably not limited either by phosphorus or by nitrogen in shallow lakes. Utilization of phosphorus in terms of chlorophyll:particulate phosphorus and chlorophyll:particulate nitrogen ratios was similar in the two groups of lakes. Significant differences were found, however, in the chlorophyll:seston ratio, higher in dimictic lakes. These observations together suggest that seston in shallow lakes contains a significant, though unpredictable contribution of detritus/mineral particles much poorer in phosphorus than those in dimictic lakes. Secchi disc depth was better explained in shallow lakes by seston variability than by chlorophyll. Thus, algal production in shallow masurian lakes seems to be limited by light conditions resulting from resuspension of non-living particles while the production in deep lakes is nutrient (both nitrogen and phosphorus) limited.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1017067406035
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  • 107
    Electronic Resource
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    Multi-lake studies in The Netherlands: trends in eutrophication (1999)
    Springer
    Hydrobiologia 408-409 (1999), S. 359-365 
    Details
    ISSN: 1573-5117
    Keywords: eutrophication ; trends ; lakes ; phosphorus ; nitrogen ; chlorophyll-a ; transparency
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The relation between (inter)national programs aiming at nutrient load reduction and changes in eutrophication has been studied for 231 Dutch lakes over the period 1980–1996. Trends in total-phosphorus (P) and total-nitrogen (N) were negative, as determined by analysis of both individual lakes and the complete data set. The relative trends in the nutrient concentrations as well as in the N/P ratio correspond with the significantly reduced P emission and the limited reduction of N emission in The Netherlands since the beginning of the 1980s. Negative trends in chlorophyll-aand positive trends in Secchi-disc transparency may be partly explained by reduced nutrient concentrations. Perspectives for the nearby future are discussed. Lake characteristics had only a minor impact on the trends. The improvement of the water quality was found for all subsets of average depth, surface area, hydraulic retention time and soil type. Furthermore, the effect of restoration measures and meteorological conditions on the trends were studied. Biomanipulation resulted in an additional improvement of several water quality variables compared to lakes that were only subject to (inter)national programs on nutrient load reduction. Specific measures resulting in additional P load reduction resulted only in lowered P concentrations. Severe winters resulted in lower chlorophyll-aconcentrations in the following summer and dry conditions in spring were favourable for all eutrophication variables in the following summer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1017086830568
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  • 108
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    Nutrient losses in runoff from grassland and shrubland habitats in Southern New Mexico: I. rainfall simulation experiments (1999)
    Springer
    Biogeochemistry 45 (1999), S. 21-34 
    Details
    ISSN: 1573-515X
    Keywords: Chihuahuan desert ; desert ; desertification ; grassland ; nitrogen ; nutrient budgets ; phosphorus ; runoff
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Geosciences
    Notes: Abstract Rainfall simulation experiments were performed in areas of semiarid grassland (Bouteloua eriopoda) and arid shrubland (Larrea tridentata) in the Chihuahuan desert of New Mexico. The objective was to compare the runoff of nitrogen (N) and phosphorus (P) from these habitats to assess whether losses of soil nutrients are associated with the invasion of grasslands by shrubs. Runoff losses from grass- and shrub-dominated plots were similar, and much less than from bare plots located in the shrubland. Weighted average concentrations of total dissolved N compounds in runoff were greatest in the grassland (1.72 mg/l) and lowest in bare plots in the shrubland (0.55 mg/l). More than half of the N transported in runoff was carried in dissolved organic compounds. In grassland and shrub plots, the total N loss was highly correlated to the total volume of discharge. We estimate that the total annual loss of N in runoff is 0.25 kg/ha/yr in grasslands and 0.43 kg/ha/yr in shrublands – consistent with the depletion of soil N during desertification of these habitats. Losses of P from both habitats were very small.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006020831706
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  • 109
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    Different induction of adaptive response to ionizing radiation in normal and neoplastic cells (1999)
    Springer
    Cell biology and toxicology 15 (1999), S. 111-119 
    Details
    ISSN: 1573-6822
    Keywords: adaptive response ; apoptosis ; low-dose radiation ; neoplastic cells ; normal cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Since the beneficial effects of low-dose radiation (0.01 Gy) are usually observed in normal cells, we investigated whether the adaptive response was induced by low-dose radiation in neoplastic cells of different origin as well as in normal cells. Cell lines used in this experiment were as follows: mouse lymphocytes (NL); L929 cells established from mouse connective tissue; primary mouse keratinocytes (PK); line 308 from mouse papilloma; X-ray sensitive lymphoma cells, L5178Y-S and EL-4 cells from mouse lymphoma. The adaptive response was determined by cell survival and apoptosis. The involvement of apoptosis in the adaptive response was examined by ELISA and TUNEL assay. Adaptive response was induced by pretreatment with low-dose radiation of 0.01 Gy in normal cells such as NL, L929, and PK, but not in L5178Y-S, EL-4, and line 308 cells. In addition, the reduction of apoptosis by pretreatment with low-dose radiation was observed in NL, L929, and PK, but not in L5178Y-S, EL-4, and line 308 cells. These results suggested that the adaptive response could be induced by pretreatment with low-dose radiation and the phenomena were observed in normal cells, not in neoplastic cells. In addition, pretreatment with low-dose radiation reduced apoptosis, suggesting that an anti-apoptotic pathway may be involved in the adaptive response.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1007525531145
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  • 110
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    A reappraisal of the role of Zn2+ in TGF-β1-induced apoptosis in primary hepatocytes (1999)
    Springer
    Cell biology and toxicology 15 (1999), S. 381-387 
    Details
    ISSN: 1573-6822
    Keywords: apoptosis ; hepatocytes ; in situ end-labeling ; TGF-β1 ; Zn2+
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract There is now a wealth of information regarding the apoptotic mode of cell death and its importance in toxicological studies in many mammalian organs including the liver. In this study, we investigated the modulatory effects of the heavy metal Zn2+ on transforming growth factor-β1 (TGF-β1)-induced apoptosis in primary rat hepatocytes. Apoptosis induced by TGF-β1 (1 ng/ml) in hepatocytes was accompanied by nuclear condensation as assessed morphologically by staining with Hoechst 33258 and DNA cleavage as detected biochemically by in situ end-labeling, field inversion and conventional gel electrophoresis. Pretreatment with 100 μmol/L Zn2+ abrogated the nuclear condensation, in situ end-labeling, and DNA laddering in TGF-β1-treated hepatocytes. Surprisingly, Zn2+ did not inhibit the formation of high-molecular-weight DNA fragments (30–50 kbp to 250–300 kbp). These data provide evidence that Zn2+ exerts its effects on the endonucleases that act downstream in the execution phase of TGF-β1-induced apoptosis in hepatocytes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1007606016901
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  • 111
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    Agricultural Chemicals in the Alluvial Aquifer of a Typical County of the Arkansas Delta (1999)
    Springer
    Environmental monitoring and assessment 58 (1999), S. 151-172 
    Details
    ISSN: 1573-2959
    Keywords: GIS ; ground water vulnerability ; leaching index ; nitrate ; pesticide ; phosphorus ; potassium ; statistical analysis ; uncertainty
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract Statistical methods and a Geographic Information System (GIS) were used to investigate potential indicators of ground water vulnerability to agricultural chemical contamination in a representative area of the Mississippi River alluvial aquifer. A total of 47 wells were sampled for analysis of nitrate, phosphorus, potassium, and 13 pesticides commonly-used in the area. Ten soil and hydrogeologic variables and five ground water vulnerability indices were examined to explain the variations of chemical concentrations. The results showed that no individual soil or hydrogeologic variables or their linear combinations could explain more than 25% of the variation of the chemical concentrations. A quadratic response surface model with the values of confining unit thickness, slope, soil permeability, depth to ground water, and recharge rate accounted for 62% of the variation of nitrate, 43% of P, and 83% of K, suggesting that the interactions among soil and hydrogeologic variables were significant. Observed trends of decreasing nitrate and P concentrations with increasing well depth and/or depth to ground water seemed to correlate with carbonate equilibrium in the aquifer and more reduced environment with depth. In view of uncertainties involved, it was recognized that the limitations associated with input data resolution used in GIS and the formulation of leaching indices limited their use for predicting ground water vulnerability. Misuse of pesticides could be another factor that would complicate the relationships between pesticide concentrations and the vulnerability indices.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006023731801
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  • 112
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    Role of water in the chemisorption of PCl3 and POCl3 on pyrogenic silica (1999)
    Springer
    Reaction kinetics and catalysis letters 66 (1999), S. 177-181 
    Details
    ISSN: 1588-2837
    Keywords: Silica ; surface ; phosphorus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The interaction of gaseous PCl3 and POCl3 with dried and wetted pyrogenic silica has been studied by IR spectroscopy. The acceleration of the chemisorption accompanied by the formation of Si−O−P bonds in the presence of water vapor has been observed only with phosphorus trichloride.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02475758
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  • 113
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    Selective alkylation of toluene with methanol overp-modified H-ZSM-5: Effect of treatment with chromium and nickel (1999)
    Springer
    Reaction kinetics and catalysis letters 66 (1999), S. 257-263 
    Details
    ISSN: 1588-2837
    Keywords: Alkylation ; toluene ; ZSM-5 ; phosphorus ; chromium ; nickel
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract H-ZSM-5 zeolite was modified with phosphorus. The obtained P/ZSM-5 catalyst was subjected to further treatments with chromium and nickel. The distribution and strength of different acid sites of zeolites were investigated by means of temperature-programmed desorption of ammonia. The active and strong acid sites were confirmed by measuring the rate constants for cracking ofn-hexane, as a probe molecule. Reduction of pore opening size of the modified ZSM-5 was monitored by a standard test reaction of probe molecules ofm-xylene and ethylbenzene. Selective alkylation of toluene with methanol top-xylene was studied over ZSM-5 and modified zeolite catalysts. The P/ZSM-5 zeolite was the most selective catalyst top-xylene but the toluene conversion decreased drastically. The addition of chromium to P/ZSM-5 zeolite increased the toluene conversion and the yield ofp-xylene was very close to P/ZSM-5 catalyst. The addition of nickel did not exhibit a significant improvement of the catalyst performance. The deactivation of catalysts, due to coke deposition during run, was also considered. P/ZSM-5 zeolite showed the lowest stability with time on stream. The addition of chromium and nickel to P/ZSM-5 zeolite increased the stability of the catalyst.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02475799
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  • 114
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    A Novel Podophyllotoxin-Derived Compound GL331 Is More Potent than Its Congener VP-16 in Killing Refractory Cancer Cells (1999)
    Springer
    Pharmaceutical research 16 (1999), S. 997-1002 
    Details
    ISSN: 1573-904X
    Keywords: GL331 ; VP-16 ; apoptosis ; cytotoxicity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Purpose. GL331 is a new homolog of VP-16, and has demonstrated more efficacious anti-cancer activity in both the in vitro and in vivo lymphoma systems. To extensively explore GL331's clinical value, we furthermore evaluate the cytotoxicity and apoptosis-inducing activity of GL331 in several human cell lines from cancers that are not normally treated with VP-16. Methods. By MTT and clonogenic survival assays, the cytotoxicities of GL331 and VP-16 were evaluated in a variety of cell lines including nasopharyngeal, hepatocellular, gastric, colon, cervical, and neuro-blastoma cancer types. Western blot analysis was performed to detect the MDR-1 level in these cell lines. By Annexin V-staining flow cytometry and detection of DNA ladders, the apoptosis-inducing activities of GL331 and VP-16 were also evaluated. Results. GL331 showed more efficacy than its congener VP-16 in killing cancer cells. The estimated ID50 of GL331 were 2.5 to 17-fold lower than those of VP-16. GL331 possessed more cell-killing activity even in MDR-1-overexpressing cell lines such as HCC36 and SW620. Its higher cytotoxicity could be attributed by the elevated ability to induce apoptotic cell death. Conclusions. GL331's overriding drug resistance and higher cancer cell-killing activity suggest its superiority in clinical cancer therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018971313256
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  • 115
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    Effects of Arbekacin and Vancomycin on Release of Lactate Dehydrogenase and Fragmentation of DNA in LLC-PK1 Kidney Epithelial Cells (1999)
    Springer
    Pharmaceutical research 16 (1999), S. 1132-1135 
    Details
    ISSN: 1573-904X
    Keywords: arbekacin ; vancomycin ; cisplatin ; apoptosis ; toxicity ; LLC-PK1 cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1011919306412
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  • 116
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    Effects of Nitrogen and Phosphorus Supply on Hexadecane Biodegradation in Soil Systems (1999)
    Springer
    Water, air & soil pollution 111 (1999), S. 1-18 
    Details
    ISSN: 1573-2932
    Keywords: biodegradation ; hydrocarbon ; nitrogen ; nutrient ratios ; phosphorus ; soils
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract The biodegradation of hexadecane (C as hexadecane-C) was assessed under 34 different external nitrogen (N supplied as NO3-N) and phosphorus (P supplied as PO4-3-P) supply conditions in order to determine how different nutrient formulations affected nutrient limitation conditions during degradation. CO2 production yields indicated that shifts in N and P supply levels resulted in variable biodegradation responses due to shifts in the limiting-nutrient (e.g., from N to P). For example, the estimated maximum fractional CO2 yield ratio was 0.24 (mg CO2-C produced mg-1 hexadecane-C) for P-limited nutrient formulations (P:hexadecane-C〈0.01), whereas the yield ratio was more than two times greater when the system was not P- limited. Similar effects were observed for N-limited (N:hexadecane- C〈0.15) versus non-N-limited formulations. The relative bioavailability of natural soil-N and soil-P also was examined. In the soil studied, background soil-N was 96.3% organic-N and was found to be largely nonbioavailable. In contrast, high CO2 yields were observed even when no external P was supplied. An iterative mathematical procedure indicated that the Olsen soil-P subfraction (inorganic soil-P plus soluble organic soil- P) best approximated bioavailable soil-P for this soil. Our results indicate that both N and P additions affect biodegradation yields, but that stoichiometrically inappropriate nutrient mixes produce suboptimal CO2 yields. We also found that the bioavailable fractions of soil-N and soil-P should be incorporated into estimating the most suitable nutrient formulations for a given contamination scenario.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1005091427942
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  • 117
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    Transport of Phosphorus and Fractionation of Residual Phosphorus in Various Horizons of a Spodosol (1999)
    Springer
    Water, air & soil pollution 109 (1999), S. 303-312 
    Details
    ISSN: 1573-2932
    Keywords: adsorption ; citrus ; fractionation ; leaching ; phosphorus ; Spodosol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract The retention and transport of P by three horizon samples (A, E, and Bh) of a Spososol (Oldsmar sand: sandy, silicious, hyperthermic Alfic Arenic Haplaquods) were evaluated using a batch-equilibration and leaching column techniques with application of P in rates equivalent to 25 and 100 kg P ha-1. Adsorption coefficient (K) values followed the order: Bh 〉 A 〉 E. Adsorption of P by the E horizon soil sample was negligible (M = 4 μg g-1 soil) as compared to that of either A or Bh horizon samples, e.g., 303 and 479 μg g-1, respectively. The leaching column study with application of P equivalent to 100 kg ha-1 showed 39, 68, and 98% of applied P were leached from the Bh, A, and E horizons, respectively, with eight pore volumes of leachate. Elution curves showed the peak P elution at the second pore volume (equivalent to 3.7 cm of water addition). After leaching with eight pore volumes, the residual P in the soil was present primarily in non-occluded Fe and Al-P forms in the A and Bh horizons.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1005081313400
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  • 118
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    New antitumor leads from a peptidomimetic library (1999)
    Springer
    International journal of peptide research and therapeutics 6 (1999), S. 325-333 
    Details
    ISSN: 1573-3904
    Keywords: antiproliferative effect ; apoptosis ; combinatorial library ; isosteric structures ; oxaniloyl hydrazides ; peptidomimetics ; substrate-binding site ; tyrosine kinase inhibition
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract A parallel combinatorial library of over 1600 compounds has been designed and synthesized for the development of new potential peptidomimetic protein tyrosine kinase (PTK) inhibitor leads. These peptidomimetic molecules are aimed at intervening with the substrate binding site of the pp60c-src enzyme. The new structures were based on known PTK inhibitors with at least two variously substituted aromatic moieties attached by spacer groups of different length and flexibility. Eleven bis-aryl-type inhibitory compounds were found in the range of 18–100 μM IC50 concentrations from combinations of 12 different substituents. Molecular modeling of the active compounds showed a characteristic distance of 12–14 Å between the farthest sp2 carbon atoms of the two aromatic rings. Conformational analysis of several peptide substrates recently found for pp60c-src PTK showed that the energy-minimized conformers had the same distance between the two aromatic moieties. Several compounds in the library not only showed remarkable PTK inhibitory activity but also a significant apoptosis-inducing effect on HT-29 human colon tumor cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008994116275
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    New antitumor leads from a peptidomimetic library (1999)
    Springer
    International journal of peptide research and therapeutics 6 (1999), S. 325-333 
    Details
    ISSN: 1573-3904
    Keywords: antiproliferative effect ; apoptosis ; combinatorial library ; isosteric structures ; oxaniloyl hydrazides ; peptidomimetics ; substrate-binding site ; tyrosine kinase inhibition
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary A parallel combinatorial library of over 1600 compounds has been designed and synthesized for the development of new potential peptidomimetic protein tyrosine kinase (PTK) inhibitor leads. These peptidomimetic molecules are aimed at intervening with the substrate binding site of the pp60c−src enzyme. The new structures were based on kown PTK inhibtors with at least two variously substituted aromatic moieties attached by spacer groups of different length and flexibility. Eleven bis-aryl-type inhibitory compounds were found in the range of 18–100 μM IC50 concentrations from combinations of 12 different substituents. Molecular modeling of the active compounds showed a characteristic distance of 12–14 Å between the farthest sp2 carbon atoms of the two aromatic rings. Conformational analysis of several peptide substrates recently found for pp60c−src PTK showed that the energyminimized conformers had the same distance between the two aromatic moieties. Several compounds in the library not only showed remarkable PTK inhibitory activity but also a significant apoptosis-inducing effect on HT-29 human colon tumor cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02443428
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    Effect of methimazole on thyroid follicular structure in rats (1999)
    Springer
    Bulletin of experimental biology and medicine 127 (1999), S. 429-432 
    Details
    ISSN: 1573-8221
    Keywords: folliculogenesis ; follicle elimination ; apoptosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Methimazole enhances blood circulation in the thyroid gland, thus stimulating folliculogenesis. Spasm of blood capillaries contacting with follicles non-adjacent to proliferating follicles leads to blood redistribution, apoptosis of the thyroid epithelium, destruction of the follicular wall, and elimination of the follicle.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02433401
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    Polyfurancarbonic acid inhibits proliferation and induces apoptosis of cultured human T lymphocytesin vitro (1999)
    Springer
    Bulletin of experimental biology and medicine 127 (1999), S. 613-614 
    Details
    ISSN: 1573-8221
    Keywords: apoptosis ; proliferation ; lymphocytes ; polyfurancarbonic acid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Polyfurancarbonic acid dose-dependently suppresses proliferation and induces apoptosis of human peripheral blood T lymphocytesin vitro. This finding indicates its possible involvement in the pathogenesis of lymphopenia during chronic renal failure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02433293
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  • 122
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    Intracellular pH in thymocytes at the early stages of apoptosis and necrosis (1999)
    Springer
    Bulletin of experimental biology and medicine 128 (1999), S. 991-993 
    Details
    ISSN: 1573-8221
    Keywords: apoptosis ; necrosis ; intracellular pH ; Na/H-exchange ; lymphocytes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Dynamics of intracellular pH during apoptotic and necrotic death of lymphocytes was studied with the help of fluorescent pH-sensitive probe BCECF. Change in intracellular pH is an early differential marker of apoptotic and necrotic types of death in thymus lymphocytes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02433186
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  • 123
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    Estimation of transmembrane potential of thymic lymphocytes during dexamethasone-induced apoptosis (1999)
    Springer
    Bulletin of experimental biology and medicine 127 (1999), S. 106-109 
    Details
    ISSN: 1573-8221
    Keywords: apoptosis ; transmembrane potential ; glucocorticoids ; thymocytes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The use of potential-sensitive fluorescent probes allowed us to estimate transmembrane potentials of the plasma (Δφp) and mitochondrial (Δφm) membranes of rat thymocytes, which were −58±3 mV and −169±7 mV, respectively. Dexamethasone-induced apoptosis led to a significant decrease in Δφp (by 55%) and Δφm (by 17%). This effects of dexamethasone was dose- and time-dependent. Changes in Δφm were greater and preceded those in Δφp.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02432815
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  • 124
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    Soluble fas antigen in serum of cancer patients (1999)
    Springer
    Bulletin of experimental biology and medicine 127 (1999), S. 296-298 
    Details
    ISSN: 1573-8221
    Keywords: tumors ; apoptosis ; soluble Fas antigen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Blood concentration of soluble Fas antigen is higher in patients with benign and malignant tumors in comparison with healthy subjects, which probably suggests its involvement into tumorigenesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02433362
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  • 125
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    Potential activity of Ca2+/Mg2+-dependent endonuclease in endometrial hyperplasia and cancer (1999)
    Springer
    Bulletin of experimental biology and medicine 127 (1999), S. 624-627 
    Details
    ISSN: 1573-8221
    Keywords: apoptosis ; Ca2+/Mg2+-dependent endonuclease ; endometrial hyperplasia ; endometrial cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Potential activity of Ca2+/Mg2+-dependent endonuclease in hyperplastic endometrial tissues is lower than in normal endometrium and practically absent in endometrial cancer tissue. Thus, molecular mechanisms of apoptosis regulation are disturbed even at the stage of hyperplasia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02433297
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