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  • Springer  (22,432)
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  • 1995-1999  (25,670)
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  • 1999  (10,346)
  • 1996  (15,324)
  • Chemistry and Pharmacology  (25,670)
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  • 1
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Dimerization is a biological regulatory mechanism employed by both soluble and membrane proteins. However, there are few structural data on the factors that govern dimerization of membrane proteins. Outer membrane phospholipase A (OMPLA) is an integral membrane enzyme which participates in ...
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  • 2
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    [s.l.] : Nature Publishing Group
    Nature 399.1999, Supplementary, A7-, (8 S.) 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] There is growing optimism among researchers in the field of brain ischaemia, as human stroke has at last become treatable and current research efforts delineate several new, potential therapies. Most strokes are caused by acute interruption of the brain arterial blood supply by a thrombus, leading ...
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  • 3
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    [s.l.] : Nature Publishing Group
    Nature 399.1999, Supplementary, A15-, (8 S.) 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Epilepsy, a brain disorder that is characterized by recurrent seizures, refers to a collection of disorders that affect 1–2% of the population worldwide. A seizure is a brief change in behaviour caused by the disordered, synchronous and rhythmic firing of populations of neurons in the ...
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  • 4
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    Nature 399.1999, Supplementary, A23-, (9 S.) 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Studies of the molecular basis of Alzheimer's disease exemplify the increasingly blurred distinction between basic and applied biomedical research.The four genes so far implicated in familial Alzheimer's disease have each been shown to elevate brain levels of the self-aggregating amyloid-β ...
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  • 5
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    Nature 399.1999, Supplementary, A32-, (8 S.) 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Parkinson's disease (PD) is one of the major neurodegenerative disorders of middle and old age, and was originally described by James Parkinson in 1817. It is characterized by a trio of cardinal symptoms—muscle rigidity, tremor and bradykinesia—but can also involve postural deficits and ...
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  • 6
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    [s.l.] : Nature Publishing Group
    Nature 399.1999, Supplementary, A40-, (8 S.) 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The cause of multiple sclerosis remains unknown after more than a century of study. Unconfirmed work has once more indicated that a viral infection may be important in the aetiology of the disease, and there is considerable evidence for an important genetic influence on disease susceptibility. The ...
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  • 7
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    Nature 398 (1999), S. 4-5 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] On 13 January this year, Brazil suffered a shock which, if you listen to some commentators abroad, shook it to its very core. In São Paulo the following week, however, the locals were unfazed. By Latin American standards, a devaluation of 25 per cent (later 45 per cent) is not much to get ...
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  • 8
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    Nature 398 (1999), S. 7-9 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] ...Last year, Luis Herrera-Estrella thought he saw an opportunity to use his science to contribute to Mexico's economy. Herrera-Estrella, a plant biotechnologist at the Centre for Research and Advanced Studies of the National Polytechnic Institute (CINVESTAV), was one of several scientists invited ...
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  • 9
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    Nature 398 (1999), S. 10-10 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Even for those fortunate scientists in Latin America who manage to obtain adequate funding, have bright graduate students to work with and fast Internet links connecting them to the world of science, a major obstacle remains on the road to first-rate research: fast access to equipment and ...
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  • 10
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    Nature 398 (1999), S. 9-20 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The challenge of combining high-quality basic research with a mission to address the country's wider needs is embodied in the experience of UNAM's Nitrogen Fixation Research Centre, in Cuernavaca. The centre was founded in 1980 with the aim of studying the molecular basis of biological nitrogen ...
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  • 11
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    Nature 398 (1999), S. 11-12 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] ...Whichever way you look at it — by the reputation of its leading researchers abroad or the orderliness of its universities, by the amount its government spends on science or the number of papers its researchers publish each year in international journals — Chile's small scientific ...
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  • 12
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    Nature 398 (1999), S. 13-13 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] ...Many astronomers regard Chile as the best place on Earth for astronomy. A stroll at night outside the dome at the Cerro Tololo Inter-American Observatory (CTIO) near La Serena in northern Chile reveals why. The sky is crystal clear, and so still that stable images of stars are a near certainty. ...
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  • 13
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    Nature 398 (1999), S. 14-15 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] ...After a hectic day fighting to save his country from currency contagion — it's Monday on the week after the Brazilian réal collapsed, and speculators have the Argentinian peso in their sights — the Argentinian chef de cabinet, Jorge Rodríguez, is relaxed and relieved to ...
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  • 14
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    Nature 398 (1999), S. 16-18 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] ...One of the least welcome tasks facing researchers at the Federal University of Rio de Janeiro — the second largest research university in Brazil — is to review grant applications from their colleagues 300 miles inland in São Paulo. “They ask for money for ...
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  • 15
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    Nature 398 (1999), S. 19-19 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] ...This year, if schedules hold, Brazil will finally realize its 20-year ambition to join the first rank of spacefaring nations. The agenda for 1999 has all the ingredients of a mature space programme, from the debut of a new Brazilian rocket to the selection of astronauts to fly on the ...
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  • 16
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    Nature 398 (1999), S. 20-21 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] ...The people of the Amazon basin are among the poorest of South America, but the region's rainforests are home to the richest diversity of life in the world. The potential of that wealth for the region was recognized implicitly for the first time in 1992, when representatives of 150 nations ...
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  • 17
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    Nature 398 (1999), S. 22-23 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] ...“Cuba's future must, by necessity, be a future of scientists,” Fidel Castro declared in 1960, soon after the Cuban revolution. Almost 40 years later, his prophesy is some way from fulfilment. But in one area of applied science — biotechnology — a concerted national effort ...
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  • 18
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    Nature 384 (1996), S. 601-601 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Washington. The US National Institutes of Health (NIH) has abandoned a plan to issue some young researchers with multiyear grants after lawyers at the Department of Health and Human Services said that it would breach departmental regulations. The reversal means that the NIH will now have to spend ...
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  • 19
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    Nature 384 (1996), S. 604-604 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] London. Britain's Ministry of Defence (MoD) last week announced two epidemio-logical studies of illness among Gulf War veterans — two years after the US government set up a study on the possible link between US troops' exposure to chemical weapons during the war and their subsequent ...
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  • 20
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    Nature 384 (1996), S. 605-605 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Washington. A consensus appears to be growing steadily among signatories to the international climate convention of 1992 on the need for binding targets for emissions of greenhouse gases. Although a review meeting in Geneva last week made little progress towards reaching an agreement on targets, ...
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  • 21
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    Nature 384 (1996), S. 502-503 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Paris. The European Commission admitted last week that genetically engineered maize has been illegally imported into the European Union (EU) since the beginning of October. One official from the commis-sion claims that it is powerless to bring an immediate end to the imports, arguing that ...
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  • 22
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    Nature 384 (1996), S. 504-504 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Sydney. Scientists have failed in their campaign to reverse the Australian govern-ment's decision to increase student fees for university courses. The finely balanced Sen-ate rejected Opposition moves to oppose the increases, which were announced in the budget in August. Two independent sena-tors ...
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  • 23
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    Nature 384 (1996), S. 508-508 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SIR - J. x C. Sellick (Nature 383, 569; 1996) has my sympathy. My family name is Ambrogi Lorenzini (without hyphen); my given name is Carlo. But Current Contents persists, in spite of my protests, in listing me as C. A. Lorenzini, which is both annoy-ing and damaging. The reason is apparently that ...
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  • 24
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    Nature 384 (1996), S. 508-508 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SIR - Doo Jung Jin (Nature 383, 662; 1996) would- rename the kilogram "einstein" on the grounds that it is the only SI basic unit that is a multiple of another unit. Is (s)he aware that the einstein is a photochemical unit corresponding to Avogadro's number of ...
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    Nature 384 (1996), S. 510-510 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SIR - High unemployment is often conceded to be a pressing social problem, but its costs can be hard to visualize. The unemployed can become practically invisi-ble to the wider society, and the social costs in crime rates, health expenditure and marriage breakdown are masked by the influence of ...
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  • 26
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    Nature 384 (1996), S. 641-643 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] To monitor the HAT activity associated with CBP in vivo, we developed an immunoprecipitation-HAT (IP-HAT) assay. Immunoprecipitaiton of CBP from whole-cell extracts (and nuclear extracts; data not shown) brings down an associated acetylase activity that is specific for histones (Fig. 1). Antibodies ...
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    Nature 384 (1996), S. 500-500 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] San Francisco. The US National Institutes of Health (NIH) has dropped a controver-sial claim to the patent for a cell line derived from a Hagahai man of Papua New Guinea which had been criticized by activist groups that oppose patents on living organisms - including human tissue. The patent, ...
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    Nature 384 (1996), S. 501-501 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Washington. A study of US researchers in the life sciences has warned against too high a level of industrial sponsorship for research at universities. Beyond a certain level of industrial sponsorship, academic productiv-ity and influence appear to fall off without a commensurate increase in ...
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    Nature 384 (1996), S. 528-528 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] IN 1866, the British statesman William Gladstone asked: "How long will the sup-ply of energy last? What will be its effect on our economic life?" He was talking about coal. Today we are mainly concerned about oil and gas, but the same questions are no less relevant. Those who would like ...
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  • 30
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] On Galileo's first inbound pass following orbital insertion, the magnetometer2 measurements followed reasonably closely the predictions from a recent model of the magnetic field of Jupiter's magnetosphere3 that we refer to as the KK96 model. (This model consists of the O6 model4 of Jupiter's ...
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  • 31
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The present-day climate of the Northern Great Plains (NGP, shaded area in Fig. 1) is highly variable as a result of its continental location and the changing influence of major air masses of differing characteristics: (1) warm dry flow from the Pacific, (2) cold dry air from the Arctic, and (3) ...
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  • 32
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    Nature 384 (1996), S. 560-564 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Anatomical studies in man and animals have shown that major blood vessels of the intracranial meninges, including the dural venous sinuses, receive a sensory innervatidn from the trigeminal nerve which originates primarily from cells in the medial (ophthalmic) part of the trigeminal ganglion13"15. ...
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  • 33
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] We began by fusing the cytochrome b2 presequence to mouse dihydrofolate reductase (DHFR), generating a hybrid precursor targeted to the intermembrane space4. This precursor was then modified to contain a unique cysteine between the uncharged stretch and the cleavage site for the inner-membrane ...
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    Nature 384 (1996), S. 524-524 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SANTER ET AL. REPLY - Michaels and Knappenberger, and Weber, in their contributions above, criticize our study1 in which we attempted to identify human influences on climate. Weber states that the increasing pattern similarity between a model signal and observed data (over 850-50 hPa) that we ...
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    Nature 384 (1996), S. 389-389 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Two key issues confront any government concerned to make the best use of scarce resources for research. The first is prioritization. The second, once priority areas have been chosen, is to find ways of spending the money in the most cost-effective way. Shortly after the Conservative party won ...
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    Nature 384 (1996), S. 393-393 
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    Notes: [Auszug] London. The United Kingdom's new Human Genetics Advisory Commission is to be chaired by Sir Colin Campbell, vice-chancellor of the University of Nottingham and former chairman of the Human Fertilization and Embryology Authority. The commission's full membership was announced on Monday (2 December) ...
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    Nature 384 (1996), S. 397-397 
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    Notes: [Auszug] Paris. Renewed calls were heard last week for regulatory systems to adapt to the threat of novel pathogens in the food supply after pies and gravy contaminated with the 0157:H7 strain of Escherichia coli killed five people in Scotland. The outbreak of food poisoning — the worst in the ...
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    Nature 384 (1996), S. 402-403 
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    Notes: [Auszug] SIR — The News article "Bias alleged in Japanese university awards" (Nature 383, 369; 1996) provides an interesting insight into some of the problems associated with Japan's university grant system. But the problems are by no means confined to the particular type of grant described in the ...
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    Nature 384 (1996), S. 404-404 
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    Notes: [Auszug] SIR — Since the Chinese Maternal and Infant Health Care Law, previously called the "eugenics and health protection law", was first proposed in December 1993, and finally promulgated on 27 October 1994, it has provoked widespread concern in the international scientific community (see Nature ...
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    Nature 384 (1996), S. 409-409 
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    Notes: [Auszug] THAT the Earth's surface consists of rigid plates that travel the globe and interact along their boundaries was a central and highly successful tenet of plate tectonic theory in the 1960s. But whereas the oceanic plates fit this model well, their continental counterparts, with their thicker, ...
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    Nature 384 (1996), S. 413-415 
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    Notes: [Auszug] THERE is a class of light nuclei that have diffuse 'nuclear halos' outside their central cores. Only discovered a decade ago, the phenomenon is also likely to occur in heavier nuclei, as yet not accessible to experiment. It has implications for the study of nuclear three-body effects and also for ...
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    Nature 384 (1996), S. 418-418 
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    Notes: [Auszug] HANS Kosterlitz, who died on 26 October in his beloved Aberdeen, often remarked that he had really wanted to be a mathematician but that medicine offered a more certain living. His mathematical grasp of problems stood him in good stead, however, over a scientific career which spanned more than 50 ...
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    Nature 384 (1996), S. 421-421 
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    Notes: [Auszug] SIR — Madan and Wells1 have explored the relationship between gill area and habitat depth. They suggest that the large gill areas found in some pelagic cephalopods enable them to cope with the hypoxic conditions present throughout much of the deep sea. This conclusion is not surprising as ...
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    Nature 384 (1996), S. 423-423 
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    Notes: [Auszug] THE largest and most impressive of the Lepidoptera are silkmoths. Wings of Paradise: The Great Saturniid Moths by John Cody includes 72 paintings of members of this family. Above is shown the comet moth of Madagascar. University of North Carolina Press, ...
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    Nature 383 (1996), S. 764-765 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] ELECTRON bubbles, used in laboratories throughout the world for probing the unusual properties of liquid helium, can be made to explode by the application of negative pressure, according to investigations by Classen et al published last month1. Helium is unique among liquids in that it can be ...
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    Nature 383 (1996), S. 239-242 
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    Notes: [Auszug] To demonstrate the entropic force-field idea in its barest form, we investigated the motions of hard spheres near the edge of a terrace (Fig. 1). We used an aqueous suspension of spherical polystyrene particles (Seradyn, Inc., Indianapolis) with diameters 0.460 um and 0.083 um and volume fractions ...
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    Notes: [Auszug] Asthma is usually recognized epidemiologically by standard symptom questionnaires or by physician diagnosis6. The nonspecific bronchial hyper-responsiveness that accompanies asthma is measured by the dose response of airflow to a broncho-constrictor such as histamine or methacholine. Atopy is ...
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    Nature 383 (1996), S. 245-247 
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    Notes: [Auszug] Our previous two-dimensional models have indicated that faulted convergent plate margins contribute to producing plate-like motion, and that the dynamically determined motion of faulted margins controls the evolution of plates and subduction dynamics7'8. In this study the incorporation of ...
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    Notes: [Auszug] It is difficult to assess the kinetics and the requirement for GTP hydrolysis by Rab proteins in situ as (1) GDP-GTP exchange occurs only on binding to the membranes7"9, where several different proteins bind GTP10, (2) non-hydrolysable analogues, such as GTP-yS, do not discriminate between GTPases, ...
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    Nature 383 (1996), S. 772-772 
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    Notes: [Auszug] Beyond Science. By John Polkinghorne. Cambridge University Press: 1996. Pp. 131. £13.95, $19.95. ALL those with even a modicum of intelligence who believe that 'creation science' should be given equal time with evolution in school curricula ought to read this charming little book. John ...
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    Nature 383 (1996), S. 771-772 
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    Notes: [Auszug] Full House: The Spread of Excellence from Plato to Darwin. By Stephen Jay Gould. Harmony/Cape. Pp. 244. $25, á£16.99. UK title is "Life's Grandeur". WHAT is the difference between a drunkard who, staggering out of a pub, ends in the gutter, and life, which, starting from primitive ...
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    Nature 383 (1996), S. 107-108 
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    Notes: [Auszug] San Diego. The increasingly tough stand being taken by US institutions against those committing misconduct in research is creating a new group of scientific fugitives á€" researchers who seek posts in laboratories abroad after investigations by American institutions cast a cloud ...
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    Nature 383 (1996), S. 109-109 
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    Notes: [Auszug] Paris. The fate of the world's largest anthropology museum, le Musee de 1'Homme (Museum of Mankind) in Paris, is hanging on the outcome of a bitter dispute between museum scientists, who want to renovate the existing museum, and art specialists who want to turn it into a museum of primitive, or ...
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    Nature 383 (1996), S. 108-108 
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    Notes: [Auszug] London. A former British police detective and a medical doctor have turned 'fraud-busters' and set up a private agency to investigate fraud and misconduct in clinical research, particularly that related to the testing of drugs. Medico-Legal Investigations is offering to conduct investigations ...
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    Nature 383 (1996), S. 110-110 
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    Notes: [Auszug] Edinburgh. The Royal Society of Edinburgh, Scotland's leading scientific organization, has joined forces with Scottish Enterprise, which is backed by the UK government, to launch a long-term strategy designed to encourage the commercial development in Scotland of scientific discoveries made in its ...
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    Nature 383 (1996), S. 111-111 
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    Notes: [Auszug] Munich. Prospects are looking bleak for rebuilding and relaunching the Cluster mission of the European Space Agency (ESA), whose four satellites were lost when Ariane-5 exploded during its first test flight earlier this summer. A search for financing from European governments has so far drawn a ...
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    Nature 383 (1996), S. 113-113 
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    Notes: [Auszug] Washington. Two scientists from Yale University in New Haven, Connecticut, are complaining that they have been denied funding by a huge federally funded breast cancer research programme, even though they received impressively high scores when ranked by scientific peer-review panels. Their ...
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    Nature 383 (1996), S. 116-116 
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    Notes: [Auszug] SIR á€" Later this month, a conference on "Women in Evolution" will be convened at the University of Arkansas. This "gathering of scientific perspectives" will be sponsored by the Sloan and Rockefeller Foundations, the National Science Foundation, the University of Arkansas and the ...
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    Nature 383 (1996), S. 119-120 
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    Notes: [Auszug] REGULATION of gene expression is fundamental to living processes, and much of it occurs at the level of transcription initiation. One form of regulation, called gene activation, produces a marked increase in the rate at which messenger RNAs are copied from the gene. The textbook model of gene ...
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    Nature 383 (1996), S. 120-120 
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    Notes: [Auszug] To study such complicated phenomena as transcrlptlonal activation, biologists turn to two tried and true approaches á€" the biochemical and the genetic. Biochemists use a strategy of reconstruction. They seek to reconstitute biological processes in test tubes. The first step ...
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    Nature 383 (1996), S. 160-163 
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    Notes: [Auszug] Dosage compensation arises to deal with aneuploidy created by the degeneration of a sex-determining chromosome that occurs when recombination with its homologue is restricted1'2. The evolutionary relationships of dosage compensation systems with the mechanisms that control sex are complex and ...
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    Nature 383 (1996), S. 131-132 
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    Notes: [Auszug] SIR á€" Mesoderm formation and its dorso-ventral specification are essential processes in vertebrate early development. The mesoderm produces many types of tissues such as notochord, muscle, bone and blood cells, arranged in the correct positions along the dorsoventral axis. The ...
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    Nature 383 (1996), S. 178-181 
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    Notes: [Auszug] We used the Streptomyces product coumermycin because it has many of the characteristics of an ideal, exogenous dimerizer. Extensive structure-function studies have localized the binding target of coumermycin to the amino-terminal 24K subdomain of the B subunit of bacterial DNA gyrase11 (GyrB). ...
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    Nature 383 (1996), S. 137-137 
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    Notes: [Auszug] ARE modern humans the chance result of vagaries in climate that afflicted the African continent more than 2 million years ago? This question has long been debated by palaeoanthropologists, especially during the 20 or so years since Elisabeth Vrba, the principal editor of Paleoclimate and Evolution, ...
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    Nature 383 (1996), S. 195-197 
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    Notes: [Auszug] Washington. A report issued earlier this year by a committee of the National Academy of Sciences (NAS), Careers in Science and Engineering, A Student Guide to Grad School and Beyond*, found that "more than half the students who have received PhDs in science and engineering obtain work outside ...
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    Nature 383 (1996), S. 785-785 
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    Notes: [Auszug] GREAT apes can think at symbolic levels traditionally considered to be uniquely human. That is the claim of the field and laboratory researchers who contribute papers to Reaching into Thought: The Minds of the Great Apes, edited by Anne E. Russon, Kirn A. Bard and Sue Taylor Parker Cambridge ...
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    Nature 383 (1996), S. 786-786 
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    Notes: [Auszug] A Perfect Harmony. By Roger A. Caras. Simon and Schuster: 1996. Pp. 271. $23. THE behavioural and cultural changes brought about in animals by domestication have been a neglected area of study. This is in great part because domestic animals have been considered to be artefacts of human culture ...
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    Nature 383 (1996), S. 787-793 
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    Notes: [Auszug] The existence of subsets of CD4+ helper T lymphocytes that differ in their cytokine secretion patterns and effector functions provides a framework for understanding the heterogeneity of normal and pathological immune responses. Defining the cellular and molecular mechanisms of ...
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    Nature 383 (1996), S. 166-168 
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    Notes: [Auszug] The elimination of neurons has long been recognized as an integral part of normal development. Invertebrates, this phenomenon is particularly well documented during the time corresponding to the innervation of target cells1, and is easily monitored as net cell numbers decrease over time. During ...
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    Nature 383 (1996), S. 27-27 
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    Notes: [Auszug] AIR Commodore Sir Frank Whittle, British pioneer of the jet engine, died on 8 August in the United States, where he had lived for the past 20 years. As one of the first to link the idea of the gas turbine with the concept of jet propulsion, Whittle was unique in persevering and bringing his ...
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    Nature 383 (1996), S. 29-29 
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    Notes: [Auszug] SIR á€" The origins of the perception of consonance and dissonance in music are a matter of debate, well-illustrated by the difficulty in assimilating contemporary atonal music, where dissonance is prominent. Here we suggest that infants are prepared to find consonance perceptually ...
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    Nature 383 (1996), S. 13-13 
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    Notes: [Auszug] RETURNEES who have their roots in China are particularly keen to develop research links with the mainland. One example is Leroy Chang, the dean of science at Hong Kong University of Science and Technology (HKUST). Born in Henan in 1937, Chang migrated first to Taiwan at the time of the communist ...
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    Nature 383 (1996), S. 197-198 
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    Notes: [Auszug] Houston. For Claire Esposito, a critical-care fellow in the Clinical Center at the US National Institutes of Health (NIH), the agency's student loan repayment policy seemed too good to be true. As it turned out there was no catch. Esposito, now in her second year of a research fellowship and with ...
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    Nature 383 (1996), S. 35-35 
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    Notes: [Auszug] Alzheimer's Research. Editor-in-chief Sarah-Jane Richards. Rapid Science. 6/yr. USA $340, elsewhere á£200 (institutional); USA $160, elsewhere á£90 (personal). AGE-RELATED neurological disorders are exacting increasingly heavy personal and financial tolls on society. ...
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    Nature 383 (1996), S. 36-36 
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    Notes: [Auszug] Microbial Drug Resistance: Mechanisms, Epidemiology, and Disease. Editor Alexander Tomasz. Liebert. 4/yr. $156. THE threat that bacteria would defeat the best efforts of the pharmaceutical industry and become untreatable has been expounded over the years by many authors. It is no coincidence ...
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    Nature 383 (1996), S. 37-37 
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    Notes: [Auszug] Folding and Design. Editors Alan R. Fersht and Fred E. Cohen. Current Biology. 6/yr. $459, á£227.50 (institutional); $159, á£97.50 (personal). THE subject of this journal, protein folding and design (with a bow to RNA as well), is among the most active and challenging ...
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    Nature 383 (1996), S. 37-37 
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    Notes: [Auszug] Biospectroscopy. Editor Laurence. A. Nafie. Wiley. 6/yr. USA $175, elsewhere $205 (institutional); USA $65, elsewhere $95 (personal). THE grass always looks greener on the other side of the fence. While biologists desperately claim to be interested in molecules, chemists are equally busy ...
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    Nature 383 (1996), S. 38-39 
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    Notes: [Auszug] Pharmaceutical News. Editor David J. Triggle. Harwood Academic. 6/yr. $393 (institutional); $252 (libraries); $72 (personal). WE are living in an era of momentous scientific and technological breakthroughs, changing disease epidemiologies and continual reforms in regulatory and healthcare ...
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    Nature 383 (1996), S. 8-8 
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    Notes: [Auszug] Washington. An expected Japanese offer to build a centrifuge for biological research on the international space station has prompted the US National Aeronautics and Space Administration (NASA) to halt its own plans for the facility, a move which may lead to redundancies at the agency's Ames ...
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    Nature 383 (1996), S. 41-41 
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    Notes: [Auszug] The Chemical Intelligencer. Editor-in-chief Istvan Hargittai. Springer. 4/yr. $69 (institutional); North America $29, elsewhere $33 (personal). "INTELLIGENCER"? What does this word mean, I wondered. Perhaps the editor, Istvan Hargittai, had actually got hold of the (in)famous Hungarian-English ...
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    Nature 383 (1996), S. 14-15 
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    Notes: [Auszug] THERE are about 120,000 scholars and students from the Chinese mainland in the United States. Most are young scientists and engineers who have arrived since 1980, following the end of the Cultural Revolution. By the early 1990s, the number of science and engineering PhDs awarded to Chinese in the ...
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    Nature 383 (1996), S. 14-14 
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    Notes: [Auszug] IT may seem odd to set up an institute for agricultural research in Singapore, which hardly has a square metre of arable land. But the aim of the new Institute of Molecular Agrobiology (IMA), affiliated with the National University of Singapore (NAS), is not to work on agriculture in the island ...
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    Nature 383 (1996), S. 36-36 
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    Notes: [Auszug] Cytokines and Molecular Therapy. Editors M. Talpaz and F. Herrmann. Dunitz. 4/yr. USA $195, Europe á£125, elsewhere á£130 (institutional); USA $99, elsewhere á£65 (personal). NATURE readers may think that 'transla-tional research' has something to do with ...
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    Nature 383 (1996), S. 20-20 
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    Notes: [Auszug] SIR á€" In the seven years during which the Nobel committees were thinking about the Nobel prize for the discovery of nuclear fission, a variety of solutions were considered1. Should the prize be awarded in chemistry or physics, to Hahn, and/or Lise Meitner, and the young Otto ...
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    Nature 383 (1996), S. 39-39 
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    Notes: [Auszug] Genome Research. Editors A. Chak-ravarti, R. Gibbs, E. Green and R. Myers. Cold Spring Harbor Laboratory Press. 12/yr. USA $495, elsewhere $545 (institutional); USA $95, elsewhere $145 (personal); USA $71.25, elsewhere $121.25 (student). GENOME projects can hardly be ignored, although some ...
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    Nature 383 (1996), S. 76-78 
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    Notes: [Auszug] Barn owls use interaural time differences for azimuthal sound localization10'11. They can locate sounds, and hence prey, with a precision of 1-2 degrees12, a capability that requires a time resolution of less than 5 us (ref. 11). The key process in the auditory system is 'phase locking': spikes ...
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    Nature 383 (1996), S. 86-89 
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    Notes: [Auszug] The murine C5a receptor (C5aR) gene4 was deleted through homologous recombination with the targeting vector shown in Fig. la. Correctly targeted Jl embryonic stem cells were used to generate chimaeric mice, several of which transmitted the targeted allele through the germ line (Fig. Ib). To confirm ...
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    Nature 383 (1996), S. 43-43 
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    Notes: [Auszug] Supramolecular Science. Editor-in-chief Wolfgang Knoll. Butterworth-Heinemann. 6/yr. $254, á£170 (institutional). SUPRAMOLECULAR chemistry proclaims that there is a chemistry beyond molecular chemistry: molecules can be programmed to organize themselves into supramolecu-lar ...
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    Nature 383 (1996), S. 43-44 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Autonomous Robots. Editor George A. Bekey. Kluwer. 4/yr. DFI468, $268 (institutional); DFI250, $105 (personal). ALTHOUGH malignant androids with human-level intelligence are likely always to be fiction, they have one property that it is both desirable and realistic to attempt to build into ...
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    [s.l.] : Nature Publishing Group
    Nature 383 (1996), S. 844-844 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Nature is a weekly international journal covering all the sciences. It is intended for an interdisciplinary readership, so all manuscripts should be written clearly and simply. Contributors should pay particular attention to the fact that English is not the first language of many readers. Space is ...
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    [s.l.] : Nature Publishing Group
    Nature 383 (1996), S. 651-651 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] To astronomers, closing down a telescope can be a traumatic experience - a bit like losing an old friend. But it is the threat to their science that underlies astronomers' concern, in the United States in particular, that smaller instruments are at risk from bud-get cuts. Nevertheless, given the ...
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  • 92
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    [s.l.] : Nature Publishing Group
    Nature 383 (1996), S. 840-843 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] In mitotic cells, DSBs and other types of DNA damage cause checkpoint-control-mediated cell-cycle arrest5'7. The checkpoint genes RAD9, RADII and RAD24 encode proteins that may interact directly with DNA during repair8; MEC1 encodes a protein that may act in a signal transduction pathway that links ...
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  • 93
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    [s.l.] : Nature Publishing Group
    Nature 382 (1996), S. 743-743 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Paris. France's planned legislation to curb traffic pollution has been criticized by the French Academy of Sciences, which says that adding oxygenated compounds, such as biofuels, to conventional fuels may create as many problems as it solves. The addition of these compounds - such ...
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  • 94
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    [s.l.] : Nature Publishing Group
    Nature 382 (1996), S. 744-744 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] New Delhi. India needs to reverse its research spending priorities by putting more emphasis on agriculture and biotechnology, and less on defence, nuclear power and space, according to a government report. The report says the current research priori-ties are out of touch with the government's ...
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    [s.l.] : Nature Publishing Group
    Nature 382 (1996), S. 745-745 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] San Francisco. A controversial plan to move aircraft used by researchers at NASA sites to one centre will cost $11.3 million to implement and save very little money, says a NASA audit. NASA's plan would move research air-craft from sites in Virginia, Ohio, Mississippi and northern ...
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  • 96
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    [s.l.] : Nature Publishing Group
    Nature 382 (1996), S. 746-746 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Munich. Biotechnology companies have conducted field trials of genetically engi-neered plants in Guatemala without inform-ing local authorities and without taking appropriate biosafety measures, claims a report by Greenpeace, the environmental pressure group. The pressure group calls ...
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    [s.l.] : Nature Publishing Group
    Nature 382 (1996), S. 747-747 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Washington. A US judge has refused South Carolina's request to block shipments to the state of spent nuclear fuel from foreign research reactors. This clears the way for two shipments of fuel rods from Europe and South America to be sent to storage pools at the Department of Energy (DoEs Savan-nah ...
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    [s.l.] : Nature Publishing Group
    Nature 382 (1996), S. 749-749 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Cape Town. President Nelson Mandela has appointed Lionel Mtshali, 60, education spokesperson of the Inkatha Freedom Party (IFP), as Minister of Arts, Culture, Science and Technology. He succeeds fellow-IFP MP Ben Ngubane, who party leader Mango-suthu Buthelezi has transferred elsewhere. Mtshali is ...
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    [s.l.] : Nature Publishing Group
    Nature 382 (1996), S. 751-754 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SCIENTISTS know philosophy and sociology as fish know water. They understand instinctively how to live in it without being aware that they are doing so. That is, until the fish bowl is stirred or (horror!) over-turned. We seem to be living in just such a time. Science is being shaken up and forced ...
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    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The retinoid X receptors (RXRs) and their heterodimeric partners possess a characteristic DNA-binding domain followed by a carboxy-terminal ligand-binding domain (LED) which is a complex region that includes subdomains for dimerization functions, transcriptional activation and, in some cases, ...
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