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  • Time Factors
  • American Association for the Advancement of Science (AAAS)  (3)
  • American Chemical Society
  • Oxford University Press
  • 1990-1994  (3)
  • 1980-1984
  • 1925-1929
  • 1990  (3)
Collection
Keywords
Publisher
  • American Association for the Advancement of Science (AAAS)  (3)
  • American Chemical Society
  • Oxford University Press
Years
  • 1990-1994  (3)
  • 1980-1984
  • 1925-1929
Year
  • 1
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    The primate hippocampal formation: evidence for a time-limited role in memory storage (1990)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1990-10-12
    Description: Clinical and experimental studies have shown that the hippocampal formation and related structures in the medial temporal lobe are important for learning and memory. Retrograde amnesia was studied prospectively in monkeys to understand the contribution of the hippocampal formation to memory function. Monkeys learned to discriminate 100 pairs of objects beginning 16, 12, 8, 4, and 2 weeks before the hippocampal formation was removed (20 different pairs at each time period). Two weeks after surgery, memory was assessed by presenting each of the 100 object pairs again for a single-choice trial. Normal monkeys exhibited forgetting; that is, they remembered recently learned objects better than objects learned many weeks earlier. Monkeys with hippocampal damage were severely impaired at remembering recently learned objects. In addition, they remembered objects learned long ago as well as normal monkeys did and significantly better than they remembered objects learned recently. These results show that the hippocampal formation is required for memory storage for only a limited period of time after learning. As time passes, its role in memory diminishes, and a more permanent memory gradually develops independently of the hippocampal formation, probably in neocortex.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zola-Morgan, S M -- Squire, L R -- MH24600/MH/NIMH NIH HHS/ -- NS19063/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1990 Oct 12;250(4978):288-90.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Veterans Affairs Medical Center, San Diego, CA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2218534" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Discrimination (Psychology) ; Hippocampus/anatomy & histology/*physiology ; *Learning ; Macaca fascicularis/*physiology ; *Memory ; Reference Values ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Defensive spray of the bombardier beetle: a biological pulse jet (1990)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1990-06-08
    Description: The defensive spray of the bombardier beetle Stenaptinus insignis is ejected in quick pulses (at about 500 pulses per second) rather than as a continuous stream. The pulsation may be a consequence of intermittency in the explosive chemical process that generates the spray. The ejection system of the beetle shows basic similarity to the pulse jet propulsion mechanism of the German V-1 "buzz" bomb of World War II.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dean, J -- Aneshansley, D J -- Edgerton, H E -- Eisner, T -- AI 02908/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1990 Jun 8;248(4960):1219-21.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Section of Neurobiology and Behavior, Cornell University, Ithaca, NY 14853.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2349480" target="_blank"〉PubMed〈/a〉
    Keywords: Aggression ; Animals ; Beetles/*physiology ; Exocrine Glands/secretion ; Male ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Activation of ras oncogenes preceding the onset of neoplasia (1990)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1990-06-01
    Description: The identification of ras oncogenes in human and animal cancers including precancerous lesions indicates that these genes participate in the early stages of neoplastic development. Yet, these observations do not define the timing of ras oncogene activation in the multistep process of carcinogenesis. To ascertain the timing of ras oncogene activation, an animal model system was devised that involves the induction of mammary carcinomas in rats exposed at birth to the carcinogen nitrosomethylurea. High-resolution restriction fragment length polymorphism analysis of polymerase chain reaction-amplified ras sequences revealed the presence of both H-ras and K-ras oncogenes in normal mammary glands 2 weeks after carcinogen treatment and at least 2 months before the onset of neoplasia. These ras oncogenes can remain latent within the mammary gland until exposure to estrogens, demonstrating that activation of ras oncogenes can precede the onset of neoplasia and suggesting that normal physiological proliferative processes such as estrogen-induced mammary gland development may lead to neoplasia if the targeted cells harbor latent ras oncogenes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kumar, R -- Sukumar, S -- Barbacid, M -- 1-RO1-CA48943/CA/NCI NIH HHS/ -- N01-CO-74101/CO/NCI NIH HHS/ -- New York, N.Y. -- Science. 1990 Jun 1;248(4959):1101-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Biology, Squibb Institute for Medical Research, Princeton, NJ 08543.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2188364" target="_blank"〉PubMed〈/a〉
    Keywords: Adenofibroma/genetics ; Animals ; Animals, Newborn ; Base Sequence ; Carcinoma/genetics ; Cell Transformation, Neoplastic/*genetics ; Estrogens/physiology ; Female ; Gene Expression Regulation, Neoplastic/*physiology ; Genes, ras/*physiology ; Mammary Glands, Animal/growth & development ; Mammary Neoplasms, Experimental/chemically induced/*genetics ; Methylnitrosourea ; Molecular Sequence Data ; Mutation ; Polymerase Chain Reaction ; Rats ; Rats, Inbred Strains ; Sexual Maturation ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
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    PAPER CURRENT
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