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  • kinetics
  • Springer  (14)
  • National Academy of Sciences
  • Periodicals Archive Online (PAO)
  • 1995-1999
  • 1985-1989  (14)
  • 1980-1984
  • 1955-1959
  • 1987  (14)
Collection
Keywords
Publisher
  • Springer  (14)
  • National Academy of Sciences
  • Periodicals Archive Online (PAO)
Years
  • 1995-1999
  • 1985-1989  (14)
  • 1980-1984
  • 1955-1959
Year
  • 1
    Electronic Resource
    Electronic Resource
    Human vitamin C requirements (1987)
    Springer
    European journal of nutrition 26 (1987), S. 125-137 
    Details
    ISSN: 1436-6215
    Keywords: vitamin C ; functions ; kinetics ; pool ; saturation ; requirements ; RDA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Medicine
    Description / Table of Contents: Zusammenfassung Die Bedeutung von Vitamin C für den menschlichen Organismus wird aus den wichtigen Funktionen ersichtlich, an denen das Vitamin beteiligt ist, wie zum Beispiel Kollagen- und Karnitinsynthesen. In neuerer Zeit entdeckt wurde seine Rolle bei der Noradrenalinsynthese, der Inaktivierung von freien Radikalen sowie der Verhinderung der Nitrosaminbildung. Die Vielfalt dieser Vitamin-C-abhängigen Funktionen läßt erkennen, daß die Bedarfsfestsetzung für Vitamin C nicht nur die Verhütung der Mangelkrankheit Skorbut anvisieren, sondern auch berücksichtigen sollte, daß alle diese Funktionen jederzeit genügend Vitamin C zur Verfügung haben müßten, um optimal reagieren zu können. Das Konzept der Gewebesättigung kommt diesem Ziel am nächsten. Studien mit einem kinetischen Modell haben ergeben, daß eine Sättigung mit täglicher Einnahme von 100 mg Vitamin C bei Nichtrauchern und von 140 mg bei Rauchern eintritt, Mengen, die als optimale Werte gelten können. Bei verschiedenen Krankheiten dürfte der Bedarf höher sein; die genauen Mengen müssen jedoch erst noch ermittelt werden.
    Notes: Summary The importance of vitamin C is reflected in its multifunctional roles which include participation in collagen and carnitine syntheses, promotion of iron absorption and the more recently discovered participation in noradrenaline synthesis, inactivation of free radical chain reactions, prevention of N-nitroso compound formation and more. Given the many extra-antiscorbutic functions of the vitamin, the Recommended Dietary Allowances (RDA) should not just prevent deficiency disease but should aim at providing sufficient amounts for all vitamin C-dependent functions to operate at full capacity. The concept of vitamin C tissue saturation is best able to meet this demand. The use of kinetic models has shown that the body pool is saturated with a daily intake of 100 mg vitamin C in non-smokers and 140 mg in smokers, amounts that may be regarded as optimal RDA values. Certain disease states may be accompanied by still higher vitamin C requirements but the exact amounts are not yet known.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02019608
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  • 2
    Electronic Resource
    Electronic Resource
    Radical desorption in the emulsion polymerisation of vinyl monomers (1987)
    Springer
    Colloid & polymer science 265 (1987), S. 58-64 
    Details
    ISSN: 1435-1536
    Keywords: Polymerisation ; emulsion ; styrene ; methylmethacrylate ; kinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The dependence of emulsion polymerisation rates on a number of important parameters is considered. Attention is paid to the use of seeded emulsion systems for the evaluation of radical desorption coefficients (k o). Experimental conditions are shown to be important. When the average number of radicals per particle is low, large changes in the rate coefficient for chain termination do not have a large effect on the kinetics. With styrene and methylmethacrylate, radical re-absorption by the polymer particles is shown to be important and radical capture efficiences can be high. Consistency is established between the results of a number of workers and values fork o are shown to be lower than those calculated from chain transfer rates.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01422665
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  • 3
    Electronic Resource
    Electronic Resource
    Kinetic mechanisms and interaction of rat liver DNA methyltransferase with defined DNA substrates (1987)
    Springer
    Molecular and cellular biochemistry 76 (1987), S. 45-54 
    Details
    ISSN: 1573-4919
    Keywords: DNA methyltransferase ; hemimethylated DNA ; kinetics ; affinity chromatography ; (rat liver)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract DNA substrate analogs were constructed from poly(dC-dG), M13, and XP12 DNA which do not contain a mixture of types of methylation sites. These were used to distinguish different kinetic mechanisms for maintenance and de novo methylation using a highly purified rat liver DNA (cytosine-5)-methyltransferase (DMase−) preparation. De novo methylation on single (ss) and double-stranded (ds) DNA was found to obey Michaelis-Menten kinetics while methylation of hemimethylated sites showed differences depending on size of the hemimethylated region. On long stretches analogous to maintenance methylation of newly replicated DNA, saturation could not be achieved and the kinetics showed non-ideal positive cooperative kinetics, while short stretches showed non-Michaelis-Menten kinetics and rapid saturation. Two types of DMase-DNA complexes could be distinguished by means of affinity chromatography on DNA-agarose matrices and in preincubation assays. The later complex, which is engaged in methyl group turnover, exhibited enhanced stability. The competitiveness of variously configured DNAs was found to parallel the stability of complex formation, e.g., ss, hemi- and ds DNA, respectively. In studies utilizing 5-bromodeoxyuridine, the thymine analog left the basic reaction mechanisms unchanged but increased the km and S0.5 while reducing the velocity of these reactions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00219397
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  • 4
    Electronic Resource
    Electronic Resource
    Kinetics of oxidation of ferrous alloys by super-heated steam (1987)
    Springer
    Oxidation of metals 28 (1987), S. 237-258 
    Details
    ISSN: 1573-4889
    Keywords: Steel oxidation ; duplex scale ; steam ; activation energy ; kinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The kinetics of the oxidation of ferrous alloys in steam (10–60 kPa) at 450–550°C have been studied by measuring both the rate of hydrogen emission and the amount of metal oxidized. Excellent agreement has been found between the amount of metal oxidized calculated from both the total mass of hydrogen produced in the reaction and the thickness of the oxide layer formed; rate constants calculated from the rate of hydrogen emission, the mass of hydrogen produced as the reaction proceeds, and the oxide formed agree within experimental error. The rate of oxidation of a 9%Cr-1%Mo alloy at 501°C was found to be independent of the partial pressure of the steam. For this alloy, the activation energy agreed with literature values obtained at higher temperatures and pressures. The effect of the chromium and silicon content on the oxidation rates is compared. The rate constants are compared with theoretical calculations, assuming that the rate is determined by diffusion of iron in the magnetite lattice. For the 9%Cr-1%Mo alloy, the parabolic rate constant and activation energy are in excellent agreement with values calculated using Wagner's theory. The experimental rate constants are greater for the alloys containing smaller amounts of chromium; diffusion of iron along magnetite grain boundaries may be the dominant mechanism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00666721
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  • 5
    Electronic Resource
    Electronic Resource
    Kinetic studies on human lactate dehydrogenase isoenzyme-catalyzed lactate-to-pyruvate reaction (1987)
    Springer
    The protein journal 6 (1987), S. 413-429 
    Details
    ISSN: 1573-4943
    Keywords: lactate dehydrogenase isoenzymes ; lactate-to-pyruvate reaction ; kinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract In order to evaluate the functional differences that may exist in human lactate dehydrogenase (LDH) isoenzymes widely used for clinical examination the kinetic and thermodynamic properties of the lactate to pyruvate reaction that they catalize were examined. Small but significant differences in the kinetic properties of the three isoenzymes were observed. The difference in the rate constants might affect the activity measurement of the individual isoenzyme as the initial velocity for the L-P reaction catalyzed will not be the same for an equal amount of enzyme. Equilibrium constants for the overall reaction in the presence and absence of pyruvate have been determined. On the basis of transition-state theory, the standard enthalpy and free-energy changes for formation of ternary activated complex were positive, while the standard entropy change was negative. Although the standard free-energy change was the same for activation by the three isoenzymes, the enthalpy and entropy changes for the LDH-3-catalyzed reaction were different from the respective values for others. A large positive value for the free-energy change and a negative value for the entropy change indicated unfavorable production of the activated complex (K infeq. sup╪ =1.89×10-16). The enzyme appears to stabilize and retain the activated complex until it dissociates into the products.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02343339
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  • 6
    Electronic Resource
    Electronic Resource
    Biotransformation of a14C-hydrogenated phenazepam analog in inbred micein vivo (1987)
    Springer
    Bulletin of experimental biology and medicine 103 (1987), S. 660-662 
    Details
    ISSN: 1573-8221
    Keywords: hydrogenated phenazepam analog ; metabolism ; kinetics ; excretion ; differences
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00841831
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  • 7
    Electronic Resource
    Electronic Resource
    Diketopiperazine Formation, Hydrolysis, and Epimerization of the New Dipeptide Angiotensin-Converting Enzyme Inhibitor RS-10085 (1987)
    Springer
    Pharmaceutical research 4 (1987), S. 392-397 
    Details
    ISSN: 1573-904X
    Keywords: angiotensin-converting enzyme (ACE) inhibitor ; RS-10085 ; degradation ; kinetics ; products ; diketopiperazine ; peptides
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The degradation kinetics, products, and mechanisms of RS-10085(1), 2-[2-(l-ethoxycarbonyl)-3-phenylpropyl]amino-l-oxopropyl]-6,7-dimethoxy-l,2,3,4-tetrahydroisoquinoline-3-carboxylic acid(S,S,S), in aqueous solution were investigated at 40, 60, and 80°C from pH 1 to pH 13. Pseudo-first-order kinetics were observed throughout the pH range studied and the log(rate)−pH profiles reflected four kinetic processes (k o, k′o, k″o, and k OH) as well as the two pKa's of 1. Excellent (〉98%) mass balance was obtained through products 2–5. At pH 4 or below, intramolecular cyclization leading to diketopiperazine 5 accounted for greater than 93% of the observed neutral- or water-catalyzed processes (k o and k′o). At pH levels greater than 5, hydrolysis giving 2 predominated and was responsible for the observed neutral- or water-catalyzed (k″o) and specific base-catalyzed (k OH) kinetic processes. Some epimerization leading to the S,S,R drug isomer (4) was also observed at pH levels greater than 7. The relative acidity of the protons at the three chiral centers of 1 was qualitatively compared and was used to explain the observed specificity in epimerization.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1016430211480
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  • 8
    Electronic Resource
    Electronic Resource
    Development of Acute Tolerance to Bumetanide: Bolus Injection Studies (1987)
    Springer
    Pharmaceutical research 4 (1987), S. 379-384 
    Details
    ISSN: 1573-904X
    Keywords: acute tolerance ; bumetanide ; kinetics ; dynamics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Bumetanide was administered intravenously to four mongrel dogs, in a random crossover fashion, at doses of 0.05 mg/kg (I), 0.15 mg/kg (II), and 0.5 mg/kg (III) where urinary losses were replaced with lactated Ringer's solution at 1.5 ml/min (hydropenic conditions) or at a dose of 0.5 mg/kg (IV) where urinary losses were replaced with lactated Ringer's solution isovolumetrically (euvolemic conditions). Serial plasma and urine samples were assayed for bumetanide by high-performance liquid chromatography (HPLC) and for sodium by flame photometry. There were no significant differences in the pharmacokinetic parameters of bumetanide among Treatments I–IV. The dynamic parameters E max (maximum effect attributable to the drug) and s (slope factor) were not different between treatments. However, a consistent, demonstrable increase in ER50 (urinary excretion rate of drug producing 50% of E max) was observed among Treatments I (2.34 µg/min), II (3.92 µg/min), and III (6.54 µg/min); also, a significant decrease in ER50 was observed between Treatment III (6.54 µg/min) and Treatment IV (2.66 µg/min). These results show that hydration status has a marked effect on natriuretic and diuretic response and that tolerance can rapidly develop within a single intravenous dose of bumetanide.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1016426110571
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  • 9
    Electronic Resource
    Electronic Resource
    In situ SAXS investigations of isothermal crystallization in poly(TMPS) fractions (1987)
    Springer
    Colloid & polymer science 265 (1987), S. 193-205 
    Details
    ISSN: 1435-1536
    Keywords: Poly(TMPS) ; in situ ; SAXS ; crystallization ; kinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The isothermal crystallization kinetics of poly(TMPS) has been measured by ISSAXS and results obtained for a molecular weight fraction (21,000) below the critical entanglement molecular weight (25,000) and another one above it (371,000). The SAXS intensity vs. time curves suggest that a single transformation mechanism exists. The SAXS long period is independent of crystallization time for both poly(TMPS) fractions. However the interlamellar thickness contribution to the long period is dependent upon molecular weight and crystallization temperature, increasing with temperature and molecular weight. The crystallite contribution also increases over the range studied. Both fractions exhibit a significant, but reversible decrease in thickness on cooling the sample from the crystallization temperature to room temperature and recyling again. The change is more pronounced for 371,000 specimen in keeping with its lower crystallinity. The path dependence of lamellar dimensions has significant implications in the morphological characterization of polymers annealed or crystallized at one temperature and then measured at another one.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01412707
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  • 10
    Electronic Resource
    Electronic Resource
    Migration of small hydrophobic molecules between micelles in aqueous solution (1987)
    Springer
    Colloid & polymer science 74 (1987), S. 55-63 
    Details
    ISSN: 1435-1536
    Keywords: Triplet energy transfer ; micelle ; solubilization ; kinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract Triplet energy transfer from 9-methylanthracene to azulene or guajazulene has been used to probe the migration of azulenes between micelles in aqueous solution. The migration of the hydrophobic solutes between small ionic and nonionic micelles had the temperature dependence expected for a process controlled by diffusion through the intermicellar solution, although the rate in some cases was substantially less than calculated from the Smoluchowski equation. Under conditions in which the micelles grow into large, probably rod-like structures, there are severe difficulties in separating the inter- and intramicellar deactivation processes. The intermicellar migration was enhanced under these conditions, in cetyltrimethylammonium surfactants on addition of chlorate ions, and in hexaethylene glycol dodecylether at temperatures approaching the cloud-point. The mechanism of this migration is discussed and compared with pertinent results from micelle relaxation kinetics and surfactant self-diffusion measurements.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01191012
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  • 11
    Electronic Resource
    Electronic Resource
    Nitrogen mineralization rates in salinevs. salt-amended soils (1987)
    Springer
    Plant and soil 104 (1987), S. 13-21 
    Details
    ISSN: 1573-5036
    Keywords: ammonification ; kinetics ; nitrification ; osmotic potentials ; soluble salts
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract Studies were conducted to compare N mineralization rates in salt-amended nonsaline soils to naturally-occurring saline soils. NaCl, CaCl2, and Na2SO4 were added to nonsaline soils at rates that produced electrical conductivities of the saturation extracts (ECe) of 5, 10, 15, and 20 dS m−1. Saline soils with similar properties were leached to the same ECc levels. N mineralization in the Chino soil was inhibited by salt addition, particularly with sodium and calcium chlorides. In the Domino soil there was some inhibition of N mineralization with the chloride salts, but enhancement with Na2SO4 was observed. Nitrification in both soils was more sensitive to salt addition than ammonification. N mineralization occurred more slowly in both leached saline soils compared to the salt-amended soils. Leached saline soils often accumulated greater amounts of inorganic N compared to their native saline counterparts, particularly with the 5 dS m−1 Chino soil (native, 44 dS m−1) and with the 5, 10, 15 and 20 dS m−1 Domino soils (native, 32 dS m−1). Kinetic parameters were estimated by the linear least squares (LLS) and the nonlinear least squares (NLLS) methods. Generally, the LLS transformation estimated greater values of potentially mineralizable N (No) and lower rate constants (k). With the NLLS equation, No values for the leached saline soils were usually lower, and k values usually higher than in the salt-amended soils. The nonsaline controls generally had the highest No and lowest k estimates. Average LLS rate constants for the salt-amended and leached saline soils were 0.055 and 0.083 for the Chino, and 0.104 and 0.137 week−1, respectively, for the Domino soils. With the NLLS equation, average k values for the salt-amended and leached saline soils were 0.087 and 0.089 for the Chino, and 0.181 and 0.387 week−1, respectively, for the Domino soils. These results suggest that N mineralization rates obtained in salt-amended nonsaline soils may not be representative of those in naturally-occurring saline soils.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02370619
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  • 12
    Electronic Resource
    Electronic Resource
    ESR spectroscopic study and kinetic discussion of the disproportionation reaction of nitrogen monoxide on CaHY-type zeolite (1987)
    Springer
    Journal of inclusion phenomena and macrocyclic chemistry 5 (1987), S. 385-395 
    Details
    ISSN: 1573-1111
    Keywords: Nitrogen monoxide ; ESR spectroscopy ; disproportionation reaction ; CaHY-type zeclite ; kinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract An ESR spectroscopic study of adsorbed NO on CaHY-type zeolite was carried out and the kinetics are discussed on the basis of a mechanistic model of the disproportionation reaction. An amount of NO less than the amount of Ca2+ distributed in Site II of the faujasite structure was admitted onto the sample maintained at 373 K. ESR spectra were recorded at room temperature. The spectra consisted of well-resolved signals. It is proposed that NO molecules on CaHY-type zeolite have two kinds of adsorption patterns. The initial formation of N2O may be expressed by the following reactions: $$[ ] + NO\mathop \rightleftharpoons \limits_{}^{K_1 } [NO],[NO] + NO\mathop \rightleftarrows \limits_{\overset{\lower0.5em\hbox{$\smash{\scriptscriptstyle\leftharpoonup}$}} {k} _2 }^{\overset{\lower0.5em\hbox{$\smash{\scriptscriptstyle\rightharpoonup}$}} {K} _2 } [N_2 O_2 ],[N_2 O_2 ] + NO\mathop \to \limits_{}^{\overset{\lower0.5em\hbox{$\smash{\scriptscriptstyle\rightharpoonup}$}} {K} _3 } [NO_2 ] + N_2 O,$$ where [], [NO] and [N2O2] denote vacant adsorption, NO adsorption, and N2O2 adsorption sites, respectively. A rate equation for N2O appearance (α) has been derived by a steady state approximation: $$\alpha = \frac{{\overset{\lower0.5em\hbox{$\smash{\scriptscriptstyle\rightharpoonup}$}} {k} _3 K_1 K_2 P^3 }}{{1 + (K_1 + \overset{\lower0.5em\hbox{$\smash{\scriptscriptstyle\rightharpoonup}$}} {k} _3 /\overset{\lower0.5em\hbox{$\smash{\scriptscriptstyle\leftharpoonup}$}} {k} _2 )P + K_1 (K_2 + \overset{\lower0.5em\hbox{$\smash{\scriptscriptstyle\rightharpoonup}$}} {k} _3 /\overset{\lower0.5em\hbox{$\smash{\scriptscriptstyle\leftharpoonup}$}} {k} _2 )P^2 }},$$ WhereP is the pressure of NO. The rate equation was used to explain the kinetic results of the disproportionation of NO.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00665372
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  • 13
    Electronic Resource
    Electronic Resource
    Inclusion of rhodamine B byβ-cyclodextrin. An equilibrium and kinetic spectrophotometric study (1987)
    Springer
    Journal of inclusion phenomena and macrocyclic chemistry 5 (1987), S. 709-716 
    Details
    ISSN: 1573-1111
    Keywords: Cyclodextrin ; rhodamine B ; equilibrium ; kinetics ; temperature-jump
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract A UV/visible spectrophotometric temperature-jump study of the inclusion of the rhodamine B zwitterion (RB) by β-cyclodextrin (βCD) to form a 1:1 complex (RB·βCD) in aqueous 1.00 mol dm−3 NaCl at pH 6.40 and 298.2 K yields:k 1=(1.3±0.2)×108 dm3 mol−1 s−1,k −1=(2.2±0.5)×104 s−1, andK 1=(5.9±2.3)×103 dm3 mol−1 for the equilibrium: $${\text{RB + }}\beta {\text{CD}}{\text{RB}} \cdot \beta {\text{CD}} K_1 $$ Under the same conditions the dimerization of RB: $${\text{2}} {\text{RB}}({\text{RB}})_2 K_d $$ is characterized byK d =(1.8±1.0)×103 dm3 mol−1. The interaction of RB with αCD and γCD is weaker than with βCD, and is discussed in terms of the relative sizes of RB and the cyclodextrin annulus. Comparisons are made with the inclusions of other dyes by cyclodextrins.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00656590
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  • 14
    Electronic Resource
    Electronic Resource
    The attachment to human buccal epithelial cells by Candida albicans: An in vitro kinetic study using concanavalin A (1987)
    Springer
    Mycopathologia 98 (1987), S. 179-184 
    Details
    ISSN: 1573-0832
    Keywords: adhesion ; C. albicans ; kinetics ; concanavalin A
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The early in vitro kinetics of Candida albicans attachment to human buccal epithelial cells was studied with the aid of an adhesion assay and solutions of concanavalin A (Con A), a lectin which is capable of inhibiting yeast adhesion. Various saccharides and putative receptor analogues were also tested. Solutions of each single reagent were added to tubes containing aliquots of mucosal cells and germinated yeasts at the beginning of a 1-hour incubation period (time O) or at 10 minute intervals during the assay. The number of yeasts attached to 200 mucosal cells was subsequently determined microscopically. Yeast adhesion remained constant following addition of phosphate-buffered saline (PBS) at time 0 or at any time thereafter. However, addition of Con A at 0, 10 or 20 minutes of incubation decreased adhesion significantly to 38%, 45% and 63% of control values. This inhibitory effect dwindled as time of incubation prior to lectin addition increased and Con A could not inhibit adhesion significantly after twenty minutes. Results obtained with Con A using live germinated yeasts were similar to those obtained with formalin-killed C. albicans. The other reagents tested failed to decrease adhesion significantly. These included the putative receptor analogues fibronectin, N-acetyl-d-glucosamine and d-galactose, and several non-specific saccharides such as α-d-methylglucopyranoside, d-ribose and d-xylose. It is suggested that in vitro attachment to human mucosal cells by C. albicans is inhibitable up to a defined point in time by a lectin with affinity for mannosecontaining surface moieties, but becomes non-reversible thereafter. This experimentally-observed irreversibility is independent of yeast cell viability.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00437653
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