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  • United States  (113)
  • Female  (75)
  • American Association for the Advancement of Science (AAAS)  (174)
  • American Chemical Society
  • Periodicals Archive Online (PAO)
  • 1985-1989  (174)
  • 1980-1984
  • 1965-1969
  • 1986  (174)
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  • American Association for the Advancement of Science (AAAS)  (174)
  • American Chemical Society
  • Periodicals Archive Online (PAO)
  • Springer  (1)
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  • 1985-1989  (174)
  • 1980-1984
  • 1965-1969
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  • 1
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    Lipoprotein mutations in pigs are associated with elevated plasma cholesterol and atherosclerosis (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-12-19
    Description: A strain of pigs bearing three immunogenetically defined lipoprotein-associated markers (allotypes), designated Lpb5, Lpr1, and Lpu1, has marked hypercholesterolemia on a low fat, cholesterol-free diet. Unlike individuals with familial hypercholesterolemia or WHHL rabbits, the affected pigs have normal low density lipoprotein receptor activity. The animals, by 7 months of age, have extensive atherosclerotic lesions in all three coronary arteries. This strain of pig represents an animal model for atherosclerosis and hypercholesterolemia associated with mutations affecting the structures of plasma lipoproteins. One of the variant apolipoproteins, Lpb5, is apolipoprotein-B. A second variant apolipoprotein (Lpr1), termed apo-R, is a 23-kilodalton protein present in both the very low density (d less than 1.006 g/ml) and the very high density (d greater than 1.21 g/ml) fractions of pig plasma. Isoforms of this protein correlate with two Lpr alleles, Lpr1 and Lpr2. The Lpr genes segregate independently of the Lpb5 and Lpu1 alleles. The Lpu1 allotype is a component of low density lipoprotein and is genetically linked to Lpb5.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rapacz, J -- Hasler-Rapacz, J -- Taylor, K M -- Checovich, W J -- Attie, A D -- AG05-856/AG/NIA NIH HHS/ -- HL30594/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1986 Dec 19;234(4783):1573-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3787263" target="_blank"〉PubMed〈/a〉
    Keywords: Alleles ; Animals ; Apolipoproteins B/genetics ; Arteriosclerosis/blood/*genetics ; Cholesterol/blood ; *Disease Models, Animal ; Female ; Genotype ; Hypercholesterolemia/blood/*genetics ; Immunologic Tests ; Lipoproteins/blood/*genetics ; Lipoproteins, LDL/blood/genetics ; Lipoproteins, VLDL/blood/genetics ; Male ; Mutation ; Receptors, LDL/metabolism ; Swine
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Radiation effects research in Japan (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-10-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shigematsu, I -- New York, N.Y. -- Science. 1986 Oct 10;234(4773):128.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3749896" target="_blank"〉PubMed〈/a〉
    Keywords: Follow-Up Studies ; Humans ; Japan ; *Nuclear Warfare ; *Radiation Injuries ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    Human multidrug-resistant cell lines: increased mdr1 expression can precede gene amplification (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-05-02
    Description: The development of simultaneous resistance to multiple structurally unrelated drugs is a major impediment to cancer chemotherapy. Multidrug resistance in human KB carcinoma cells selected in colchicine, vinblastine, or Adriamycin is associated with amplification of specific DNA sequences (the multidrug resistance locus, mdr1). During colchicine selection resistance is initially accompanied by elevated expression of a 4.5-kilobase mdr1 messenger RNA (mRNA) without amplification of the corresponding genomic sequences. During selection for increased levels of resistance, expression of this mRNA is increased simultaneously with amplification of mdr1 DNA. Increased expression and amplification of mdr1 sequences were also found in multidrug-resistant sublines of human leukemia and ovarian carcinoma cells. These results suggest that increased expression of mdr1 mRNA is a common mechanism for multidrug resistance in human cells. Activation of the mdr1 gene by mutations or epigenetic changes may precede its amplification during the development of resistance.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shen, D W -- Fojo, A -- Chin, J E -- Roninson, I B -- Richert, N -- Pastan, I -- Gottesman, M M -- New York, N.Y. -- Science. 1986 May 2;232(4750):643-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3457471" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Colchicine/pharmacology ; Cricetinae ; Cricetulus ; DNA, Neoplasm/genetics ; Doxorubicin/pharmacology ; *Drug Resistance ; Female ; *Gene Amplification ; Humans ; Leukemia, Lymphoid/drug therapy ; Neoplasms/*drug therapy/genetics ; Nucleic Acid Hybridization ; Ovarian Neoplasms/drug therapy ; RNA, Messenger/genetics ; Vinblastine/pharmacology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Congress likely to halt shrinkage in AIDS funds (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-03-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Norman, C -- New York, N.Y. -- Science. 1986 Mar 21;231(4744):1364-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3952488" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/*economics ; National Institutes of Health (U.S.) ; Research Support as Topic ; United States ; United States Dept. of Health and Human Services
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    NIH gets a friendly hearing on Capitol Hill (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-03-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Norman, C -- New York, N.Y. -- Science. 1986 Mar 21;231(4744):1364.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3952487" target="_blank"〉PubMed〈/a〉
    Keywords: Budgets ; Legislation, Medical ; *National Institutes of Health (U.S.) ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Science escapes brunt of budget ax (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-02-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Norman, C -- New York, N.Y. -- Science. 1986 Feb 21;231(4740):785-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3945809" target="_blank"〉PubMed〈/a〉
    Keywords: Legislation as Topic ; National Institutes of Health (U.S.)/*economics ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    AIDS priority fight goes to court (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-01-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Norman, C -- New York, N.Y. -- Science. 1986 Jan 3;231(4733):11-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3001932" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/*microbiology ; Antibodies, Viral/analysis ; Deltaretrovirus/*isolation & purification ; France ; HIV Antibodies ; Humans ; Patents as Topic/*legislation & jurisprudence ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    Subsidizing research: role of the university (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-06-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rosenzweig, R M -- New York, N.Y. -- Science. 1986 Jun 20;232(4757):1508-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3715459" target="_blank"〉PubMed〈/a〉
    Keywords: Government Agencies ; *Research Support as Topic ; United States ; Universities/*economics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    $2-billion program urged for AIDS (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-11-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Norman, C -- New York, N.Y. -- Science. 1986 Nov 7;234(4777):661-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3775357" target="_blank"〉PubMed〈/a〉
    Keywords: *Acquired Immunodeficiency Syndrome ; Humans ; Research Support as Topic ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    Vaccine compensation proposals abound on Capitol Hill (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-07-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1986 Jul 25;233(4762):415.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3487830" target="_blank"〉PubMed〈/a〉
    Keywords: Child ; *Compensation and Redress ; Diphtheria Toxoid/adverse effects ; Diphtheria-Tetanus-Pertussis Vaccine ; Drug Combinations/adverse effects ; Federal Government ; Humans ; *Legislation, Medical ; Pertussis Vaccine/adverse effects ; Tetanus Toxoid/adverse effects ; United States ; Vaccines/*adverse effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 11
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    Drug export bill torpedoed by amendment (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-07-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1986 Jul 4;233(4759):22.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3715472" target="_blank"〉PubMed〈/a〉
    Keywords: *Legislation, Pharmacy ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 12
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    Adult decisions (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-01-31
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Soloway, A H -- New York, N.Y. -- Science. 1986 Jan 31;231(4737):442.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3941905" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Child ; Drug Therapy/*standards ; *Government Agencies ; Humans ; *Patient Participation ; Social Responsibility ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 13
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    Calcium antagonist receptors in cardiomyopathic hamster: selective increases in heart, muscle, brain (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-04-25
    Description: The Syrian cardiomyopathic hamster has a hereditary disease in which a progressive myocardial necrosis mimics human forms of cardiac hypertrophy. Lesions are associated with calcium overload and can be prevented with the calcium antagonist verapamil. Numbers of receptor binding sites for calcium antagonists in heart, brain, skeletal muscle, and smooth muscle were markedly increased in cardiomyopathic hamsters. The uptake of calcium-45 into brain synaptosomes was also increased in cardiomyopathic hamsters. The increase in calcium antagonist receptors and related voltage-sensitive calcium channels may be involved in the pathogenesis of this cardiomyopathy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wagner, J A -- Reynolds, I J -- Weisman, H F -- Dudeck, P -- Weisfeldt, M L -- Snyder, S H -- HL-17655/HL/NHLBI NIH HHS/ -- MH-18501/MH/NIMH NIH HHS/ -- NS-16375/NS/NINDS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1986 Apr 25;232(4749):515-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3008330" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/metabolism/physiopathology ; *Brain Chemistry ; Calcium/metabolism ; Calcium Channels ; Cardiomyopathy, Hypertrophic/*physiopathology ; Cricetinae ; Disease Models, Animal ; Female ; Heart/physiopathology ; Male ; Mesocricetus ; Muscle, Smooth/analysis/metabolism ; Muscles/*analysis/metabolism/physiopathology ; Myocardium/*analysis/metabolism ; Nifedipine/analogs & derivatives/metabolism ; Nitrendipine ; Receptors, Nicotinic/*analysis/metabolism/physiology ; Synaptosomes/metabolism ; Verapamil/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 14
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    Fertility in the United States (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-10-31
    Description: From the postwar high of 3.8 births per woman at the peak of the baby boom, the total fertility rate in the United States has fallen to 1.8, where it has remained unchanged for nearly a decade. This below-replacement level of fertility has, in recent decades, characterized most Western countries, some of which have shown declines to well below 1.5 births per woman. Were it not for the continued infusion of immigrants, the U.S. population, which already shows the aging characteristic of low fertility, would stop growing and begin to decline before the middle of the next century. The low fertility in the United States has been accomplished by a postponement of marriage and by the widespread use of contraception, with heavy reliance on surgical sterilization as a contraceptive method. Judging from the experience of other Western countries and from our own historical experience of two centuries of fertility decline interrupted only by the baby boom, as well as from the absence of social trends that would counteract those contributing to that decline, the prognosis is for a continued low level of fertility in the United States.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Westoff, C F -- New York, N.Y. -- Science. 1986 Oct 31;234(4776):554-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3532324" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; *Birth Rate ; Contraception/history ; Ethnic Groups ; Female ; Fertility ; Forecasting ; History, 20th Century ; Humans ; Population Dynamics ; Population Growth ; Pregnancy ; Pregnancy in Adolescence ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 15
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    Billings ovulation method (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-02-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wilson, M A -- New York, N.Y. -- Science. 1986 Feb 21;231(4740):783.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3945808" target="_blank"〉PubMed〈/a〉
    Keywords: *Family Planning Services ; Female ; Humans ; Ovulation
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 16
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    Senate votes to expand anti-AIDS drug trials (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-09-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Barnes, D M -- New York, N.Y. -- Science. 1986 Sep 26;233(4771):1382.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3529390" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/*drug therapy ; Clinical Trials as Topic ; Government Agencies ; Humans ; National Institutes of Health (U.S.) ; Thymidine/*analogs & derivatives/therapeutic use ; United States ; Zidovudine
    Print ISSN: 0036-8075
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  • 17
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    Dynamics of lymphocyte-endothelial interactions in vivo (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-01-24
    Description: The dynamics of the attachment of lymphocytes to the endothelium of high endothelial venules in murine Peyer's patches were studied in vivo. Lymphocytes adhered readily to the endothelium lining these vessels, but most of the adhering cells detached within a few seconds. Many lymphocytes, however, experienced multiple collisions with the high endothelial venules, and this substantially increased the efficiency of lymphocyte collection by these vessels.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bjerknes, M -- Cheng, H -- Ottaway, C A -- New York, N.Y. -- Science. 1986 Jan 24;231(4736):402-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3941903" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Endothelium/physiology ; Female ; In Vitro Techniques ; Lymphocytes/*physiology ; Mice ; Mice, Inbred BALB C ; Microscopy, Fluorescence ; Peyer's Patches/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 18
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    Immunoregulatory feedback between interleukin-1 and glucocorticoid hormones (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-08-08
    Description: The production and action of immunoregulatory cytokines, including interleukin-1 (IL-1), are inhibited by glucocorticoid hormones in vivo and in vitro. Conversely, glucocorticoid blood levels were increased by factors released by human leukocytes exposed to Newcastle disease virus preparations. This activity was neutralized by an antibody to IL-1. Therefore the capacity of IL-1 to stimulate the pituitary-adrenal axis was tested. Administration of subpyrogenic doses of homogeneous human monocyte-derived IL-1 or the pI 7 form of human recombinant IL-1 to mice and rats increased blood levels of adrenocorticotropic hormone (ACTH) and glucocorticoids. Another monokine, tumor necrosis factor, and the lymphokines IL-2 and gamma-interferon had no such effects when administered in doses equivalent to or higher than those of IL-1. The stimulatory effect of IL-1 on the pituitary-adrenal axis seemed not to be mediated by the secondary release of products from mature T lymphocytes since IL-1 was endocrinologically active when injected into athymic nude mice. These results strongly support the existence of an immunoregulatory feedback circuit in which IL-1 acts as an afferent and glucocorticoid as an efferent hormonal signal.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Besedovsky, H -- del Rey, A -- Sorkin, E -- Dinarello, C A -- AI15614/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1986 Aug 8;233(4764):652-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3014662" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenocorticotropic Hormone/blood/physiology ; Animals ; Corticosterone/blood/physiology ; Female ; Glucocorticoids/blood/immunology/*physiology ; Humans ; Interleukin-1/immunology/pharmacology/*physiology ; Leukocytes/drug effects/physiology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C3H ; Mice, Nude ; Newcastle disease virus/immunology ; Rats ; Rats, Inbred Strains
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 19
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    Human beta-adrenoceptors: relation of myocardial and lymphocyte beta-adrenoceptor density (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-03-28
    Description: In human right atria obtained from 21 patients during open-heart surgery, beta-adrenoceptor density [assessed by iodine-125-labeled (-)-cyanopindolol binding] and responsiveness (positive inotropic responses to isoprenaline) were linearly related to the beta-adrenoceptor density in the corresponding circulating lymphocytes. This direct relation of human myocardial and lymphocyte beta-adrenoceptor alterations, therefore, makes it possible to monitor drug- or disease-induced beta-adrenoceptor changes in tissues not easily accessible in humans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brodde, O E -- Kretsch, R -- Ikezono, K -- Zerkowski, H R -- Reidemeister, J C -- New York, N.Y. -- Science. 1986 Mar 28;231(4745):1584-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3006250" target="_blank"〉PubMed〈/a〉
    Keywords: Female ; Heart Atria ; Humans ; In Vitro Techniques ; Isoproterenol/pharmacology ; Lymphocytes/*metabolism ; Male ; Middle Aged ; Myocardial Contraction/drug effects ; Myocardium/*metabolism ; Receptors, Adrenergic, beta/*metabolism
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 20
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    Atrial natriuretic peptide elevation in congestive heart failure in the human (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-03-07
    Description: A sensitive radioimmunoassay for atrial natriuretic peptide was used to examine the relation between circulating atrial natriuretic peptide and cardiac filling pressure in normal human subjects, in patients with cardiovascular disease and normal cardiac filling pressure, and in patients with cardiovascular disease and elevated cardiac filling pressure with and without congestive heart failure. The present studies establish a normal range for atrial natriuretic peptide in normal human subjects. These studies also establish that elevated cardiac filling pressure is associated with increased circulating concentrations of atrial natriuretic peptide and that congestive heart failure is not characterized by a deficiency in atrial natriuretic peptide, but with its elevation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Burnett, J C Jr -- Kao, P C -- Hu, D C -- Heser, D W -- Heublein, D -- Granger, J P -- Opgenorth, T J -- Reeder, G S -- New York, N.Y. -- Science. 1986 Mar 7;231(4742):1145-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2935937" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Aged ; Atrial Natriuretic Factor/*blood ; Cardiovascular Diseases/blood ; Female ; Heart Failure/*blood ; Hemodynamics ; Humans ; Male ; Middle Aged ; Radioimmunoassay
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 21
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    Drug-resistant Salmonella in the United States: an epidemiologic perspective (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-11-21
    Description: Salmonellosis poses a health problem of large proportions in the United States. Annually, it accounts for more than 40,000 reported cases, 500 deaths, and financial costs well in excess of $50 million. Antimicrobial resistance is increasing in Salmonella strains, a finding that has important public health implications. Although the chain of transmission of the bacteria is often complex, combined epidemiologic and laboratory studies with the use of new methods in molecular biology make it possible to trace antimicrobial-resistant salmonellae to their primary source--foods of animal origin. These studies suggest that the antimicrobial drugs to which food animals are exposed provide selective pressure that leads to the appearance and persistence of resistant strains.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, M L -- Tauxe, R V -- New York, N.Y. -- Science. 1986 Nov 21;234(4779):964-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3535069" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anti-Bacterial Agents/*pharmacology/therapeutic use ; Chloramphenicol/pharmacology ; Disease Outbreaks/*epidemiology ; *Drug Resistance, Microbial ; Gastroenteritis/etiology ; Humans ; Meningitis/drug therapy ; Salmonella/*drug effects ; Salmonella Food Poisoning ; Salmonella Infections/epidemiology ; Salmonella Infections, Animal/transmission ; Sepsis/drug therapy ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 22
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    Harvard researchers retract data in immunology paper (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-11-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culliton, B J -- New York, N.Y. -- Science. 1986 Nov 28;234(4780):1069.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3535072" target="_blank"〉PubMed〈/a〉
    Keywords: *Publishing ; *Retraction of Publication as Topic ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 23
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    OMB slashes NIH budget for FY 88 (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-12-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culliton, B J -- New York, N.Y. -- Science. 1986 Dec 19;234(4783):1494.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3787258" target="_blank"〉PubMed〈/a〉
    Keywords: Budgets/*legislation & jurisprudence ; Financial Management/*legislation & jurisprudence ; *National Institutes of Health (U.S.) ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 24
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    Pressure to cut the deficit creates uncertainty for biomedical research (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-05-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culliton, B J -- New York, N.Y. -- Science. 1986 May 2;232(4750):564-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3961496" target="_blank"〉PubMed〈/a〉
    Keywords: *National Institutes of Health (U.S.) ; Research Support as Topic/*economics ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 25
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    Perfumes and preference (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-03-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Easton, T A -- New York, N.Y. -- Science. 1986 Mar 14;231(4743):1235.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3945820" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Female ; Homosexuality ; Humans ; Male ; *Perfume ; Rats ; *Sexual Behavior
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 26
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    Estrogen-induced factors of breast cancer cells partially replace estrogen to promote tumor growth (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-06-20
    Description: The hormone 17 beta-estradiol acts through its receptor system to induce MCF-7 human breast cancer cells to form tumors in athymic mice. In vitro studies have identified the production of estrogen-induced growth factors from MCF-7 cells that may have a role in growth control. These induced growth factors were sufficient to stimulate MCF-7 tumor growth in ovariectomized athymic mice, thus partially replacing estradiol. Growth factors may act as estrogen-induced "second messengers" in estrogen-responsive growth of human breast cancer.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dickson, R B -- McManaway, M E -- Lippman, M E -- New York, N.Y. -- Science. 1986 Jun 20;232(4757):1540-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3715461" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Breast Neoplasms/*pathology ; Cell Division ; Cell Line ; Culture Media ; Estradiol/*physiology ; Female ; Humans ; Mice ; Mice, Nude ; Neoplasm Transplantation ; Ovariectomy ; Receptors, Estradiol/*physiology ; Receptors, Estrogen/*physiology ; Transplantation, Heterologous
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 27
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    Rifkin against the world (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-08-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1986 Aug 15;233(4765):704-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3461560" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Genetic Engineering ; Government Agencies ; Pseudorabies/prevention & control ; Swine ; Swine Diseases/prevention & control ; United States ; Viral Vaccines
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  • 28
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    Transplantation of fetal hematopoietic stem cells in utero: the creation of hematopoietic chimeras (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-08-15
    Description: Transplantation of normal, immature, fetal hematopoietic cells into a preimmune fetal recipient with a congenital hemoglobinopathy may allow partial reconstitution of normal hemoglobin production without the complications associated with postnatal bone marrow transplantation (immunosuppression and the occurrence of graft versus host disease). In order to test this hypothesis the naturally occurring polymorphism at the beta-hemoglobin locus of the sheep was used as a marker for engraftment and hematopoietic chimerism. Intraperitoneal injection of allogeneic fetal stem cells into normal fetal lambs resulted in hematopoietic chimerism in three of four surviving recipients. This chimerism has been sustained for 6 months after birth and 9 months after engraftment, without evidence of graft versus host disease, and without the use of immunosuppressive therapy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Flake, A W -- Harrison, M R -- Adzick, N S -- Zanjani, E D -- AM-24027/AM/NIADDK NIH HHS/ -- AM-29890/AM/NIADDK NIH HHS/ -- AM-30914/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1986 Aug 15;233(4765):776-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2874611" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Chimera ; Female ; Fetus ; Graft vs Host Disease ; *Hematopoietic Stem Cell Transplantation ; Hemoglobin A/*analysis ; Hemoglobins/*analysis ; Pregnancy ; Sheep ; Transplantation, Homologous
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 29
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    The neuroendocrine thymus: coexistence of oxytocin and neurophysin in the human thymus (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-04-25
    Description: Immunoreactive oxytocin and neurophysin were identified and measured by radioimmunoassay in human thymus extracts. Serial dilutions of extracts paralleled the appropriate standard curves. Thymus-extracted oxytocin and neurophysin eluted in the same positions as reference preparations on Sephadex G-75. Authenticity of oxytocin was confirmed by biological assay and high-performance liquid chromatography analysis. In most instances, thymus contents of oxytocin and neurophysin were far greater than those expected from known circulating concentrations and declined with increasing age. The molar ratio of oxytocin to neurophysin in thymus was similar to that found in the hypothalamo-neurohypophyseal system, which strongly suggested with the other data a local synthesis of oxytocin. These findings indicate the presence of neurohypophyseal peptides in the human thymus and further support the concept of a neuroendocrine function integrated in an immune structure.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Geenen, V -- Legros, J J -- Franchimont, P -- Baudrihaye, M -- Defresne, M P -- Boniver, J -- New York, N.Y. -- Science. 1986 Apr 25;232(4749):508-11.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3961493" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Age Factors ; Child ; Chromatography, Gel ; Chromatography, High Pressure Liquid ; Female ; Humans ; Infant, Newborn ; Male ; Middle Aged ; Myasthenia Gravis/physiopathology ; Neurophysins/*analysis/isolation & purification/physiology ; Oxytocin/*analysis/isolation & purification/physiology ; Radioimmunoassay ; Thymus Gland/*analysis/physiology/physiopathology
    Print ISSN: 0036-8075
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  • 30
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    Nutrition policy controversies (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-05-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Harper, A E -- New York, N.Y. -- Science. 1986 May 16;232(4752):810-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3704627" target="_blank"〉PubMed〈/a〉
    Keywords: Diet ; Female ; Humans ; Life Expectancy ; Male ; *Nutritional Physiological Phenomena
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  • 31
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    Anti-idiotypic antibodies bear the internal image of a human tumor antigen (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-04-04
    Description: Goat antibodies to idiotypes (anti-idiotypic antibodies; Ab2) that recognize an idiotype associated with the combining site of a BALB/c mouse IgG2a monoclonal antibody (Ab1) to human gastric carcinoma were used to immunize BALB/c mice and rabbits. A monoclonal anti-anti-idiotypic antibody (Ab3) of IgG1 isotype was obtained after immunization of mice. The Ab3 and the Ab1 showed identical binding specificities and bound with similar avidities to the same tumor antigen. The induction of Ab1-like Ab3 by Ab2 was not restricted to mice, since Ab3 could also be induced in rabbits. Both the mouse- and the rabbit-derived Ab3 bound the same gastrointestinal cancer-associated antigen as Ab1. These findings indicate that Ab2 induced the formation of antigen-specific Ab3, probably because it bears the internal image of the tumor-associated antigen. This Ab2 may therefore have potential for modulating the immune response of cancer patients to their tumors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Herlyn, D -- Ross, A H -- Koprowski, H -- CA-10815/CA/NCI NIH HHS/ -- CA-21124/CA/NCI NIH HHS/ -- CA-33490/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1986 Apr 4;232(4746):100-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3952496" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Antibodies ; Antibodies, Monoclonal ; Antigen-Antibody Complex ; Antigens, Neoplasm/*immunology ; Female ; Goats/immunology ; Humans ; Immunoglobulin Idiotypes/*immunology ; Mice ; Mice, Inbred BALB C/immunology ; Neoplasms/immunology ; Rabbits/immunology
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  • 32
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    NIMH review of fraud charge moves slowly (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-12-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1986 Dec 19;234(4783):1488-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2878494" target="_blank"〉PubMed〈/a〉
    Keywords: Antipsychotic Agents/*adverse effects/therapeutic use ; *Biomedical Research ; *Crime ; Dyskinesia, Drug-Induced ; Federal Government ; *Fraud ; Government Regulation ; Humans ; Intellectual Disability/*psychology ; National Institute of Mental Health (U.S.) ; *Research ; Risk Assessment ; United States
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  • 33
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    Regulating software for medical devices (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-10-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1986 Oct 3;234(4772):20.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3755844" target="_blank"〉PubMed〈/a〉
    Keywords: Computers/*legislation & jurisprudence ; *Equipment and Supplies ; Humans ; Software/*legislation & jurisprudence ; United States ; *United States Food and Drug Administration
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  • 34
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    Growing focus on criminal careers (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-09-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1986 Sep 26;233(4771):1377-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3749882" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; *Adolescent Behavior ; Adult ; *Crime ; Government Agencies ; Humans ; Middle Aged ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 35
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    Researchers grapple with problems of updating classic psychological test (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-09-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1986 Sep 19;233(4770):1249-51.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3749875" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Female ; Humans ; *Mmpi ; Male ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 36
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    Homelessness: experts differ on root causes (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-05-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1986 May 2;232(4750):569-70.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3961497" target="_blank"〉PubMed〈/a〉
    Keywords: Child ; Family ; Female ; *Homeless Persons/psychology ; Humans ; Mental Disorders/psychology ; Mothers ; United States
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  • 37
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    New growth industry in human growth hormone? (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-10-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G -- New York, N.Y. -- Science. 1986 Oct 3;234(4772):22-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3749891" target="_blank"〉PubMed〈/a〉
    Keywords: Body Height/drug effects ; Child ; Female ; *Growth Hormone/biosynthesis/therapeutic use ; Humans ; Male ; Recombinant Proteins/biosynthesis/therapeutic use
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  • 38
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    High court says no to administration's Baby Doe rules (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-06-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1986 Jun 27;232(4758):1595-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3715464" target="_blank"〉PubMed〈/a〉
    Keywords: Congenital Abnormalities/*therapy ; Ethics, Medical ; Humans ; United States ; United States Dept. of Health and Human Services
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  • 39
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    Researchers hunt for Alzheimer's disease gene (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-04-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G -- New York, N.Y. -- Science. 1986 Apr 25;232(4749):448-50.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3961489" target="_blank"〉PubMed〈/a〉
    Keywords: Aged ; Alzheimer Disease/*genetics ; Family ; Female ; Genes ; Humans ; Male ; Middle Aged ; Risk
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  • 40
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    Receptor-associated resistance to growth hormone-releasing factor in dwarf "little" mice (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-04-25
    Description: Anterior pituitaries from the dwarf mouse strain "little" did not release growth hormone or accumulate adenosine 3',5'-monophosphate (cyclic AMP) in response to human and rat growth hormone-releasing factor (GRF). Dibutyryl cyclic AMP, as well as the adenylate cyclase stimulators forskolin and cholera toxin, markedly stimulated growth hormone (GH) release. The basis of the GH deficiency in the little mouse may therefore be a defect in an early stage of GRF-stimulated GH release related either to receptor binding or to the function of the hormone-receptor complex.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jansson, J O -- Downs, T R -- Beamer, W G -- Frohman, L A -- AM 17947/AM/NIADDK NIH HHS/ -- AM 30667/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1986 Apr 25;232(4749):511-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3008329" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Colforsin/pharmacology ; Cyclic AMP/analysis ; Dwarfism, Pituitary/*physiopathology ; Female ; Growth Hormone-Releasing Hormone/metabolism/pharmacology/physiology/secretion ; Humans ; Mice ; Mice, Inbred C57BL ; Mice, Mutant Strains/*physiology ; Pituitary Gland, Anterior/analysis/drug effects/physiopathology/secretion ; Receptors, Cell Surface/metabolism/*physiology ; *Receptors, Neuropeptide ; *Receptors, Pituitary Hormone-Regulating Hormone
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Diet advice, with a grain of salt and a large helping of pepper (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-02-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1986 Feb 7;231(4738):537-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3003903" target="_blank"〉PubMed〈/a〉
    Keywords: Cholesterol/adverse effects ; *Diet ; Dietary Fats/adverse effects ; Dietary Fiber/administration & dosage ; Food-Processing Industry ; Humans ; National Institutes of Health (U.S.) ; Nutritional Sciences/education ; United States
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    The 1986 Nobel Prize for physiology or medicine (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-10-31
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J L -- New York, N.Y. -- Science. 1986 Oct 31;234(4776):543-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3532323" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Epidermal Growth Factor ; History, 20th Century ; Italy ; Mice ; *Nerve Growth Factors ; *Nobel Prize ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    The slow, insidious natures of the HTLV's (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-01-31
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J L -- New York, N.Y. -- Science. 1986 Jan 31;231(4737):450-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3001937" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/*microbiology/transmission ; Deltaretrovirus/*pathogenicity ; Female ; Humans ; Male ; National Institutes of Health (U.S.) ; Sex ; United States
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  • 44
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    The hypogonadal mouse: reproductive functions restored by gene therapy (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-12-12
    Description: The hypogonadal (hpg) mouse lacks a complete gonadotropin-releasing hormone (GnRH) gene and consequently cannot reproduce. Introduction of an intact GnRH gene into the genome of these mutant mice resulted in complete reversal of the hypogonadal phenotype. Transgenic hpg/hpg homozygotes of both sexes were capable of mating and producing offspring. Pituitary and serum concentrations of luteinizing hormone, follicle-stimulating hormone, and prolactin were restored to those of normal animals. Immunocytochemistry and in situ hybridization showed that GnRH expression was restored in the appropriate hypothalamic neurons of the transgenic hpg animals, an indication of neural-specific expression of the introduced gene.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mason, A J -- Pitts, S L -- Nikolics, K -- Szonyi, E -- Wilcox, J N -- Seeburg, P H -- Stewart, T A -- New York, N.Y. -- Science. 1986 Dec 12;234(4782):1372-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3097822" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Female ; Follicle Stimulating Hormone/blood ; Gene Expression Regulation ; *Genetic Engineering ; Gonadotropin-Releasing Hormone/genetics ; Histocytochemistry ; Hypogonadism/*genetics ; Hypothalamus/analysis/cytology ; Infertility/genetics/*therapy ; Luteinizing Hormone/blood ; Male ; Mice ; Mutation ; Neurons/analysis ; Phenotype ; Prolactin/blood ; Tissue Distribution
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Age and infertility (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-09-26
    Description: Direct evidence on age patterns of infecundity and sterility cannot be obtained from contemporary populations because such large fractions of couples use contraception or have been sterilized. Instead, historical data are exploited to yield upper bounds applicable to contemporary populations on the proportions sterile at each age. Examination of recent changes in sexual behavior that may increase infecundity indicates that sexually transmitted infections, the prime candidate for hypothesized rises in infertility, are unlikely to have added to infecundity to any great extent. These results imply that a woman in a monogamous union faces only moderate increases in the probability of becoming sterile (or infecund) until her late thirties. Nevertheless, it appears that recent changes in reproductive behavior were guaranteed to result in the perception that infecundity is on the rise.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Menken, J -- Trussell, J -- Larsen, U -- HD11720/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1986 Sep 26;233(4771):1389-94.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3755843" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Age Factors ; *Aging ; Female ; *Fertility ; Humans ; Infertility, Female/*epidemiology ; Infertility, Male/*epidemiology ; Male ; Marriage ; Middle Aged ; United States
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    Effects of alcohol on the generation and migration of cerebral cortical neurons (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-09-19
    Description: Prenatal exposure to alcohol produces many developmental defects of the central nervous system, such as microcephaly, mental retardation, motor dysfunction, and cognitive deficiencies. Therefore, the generation of neurons in the cerebral cortex was examined in the offspring of female rats fed a diet containing ethanol. Prenatal exposure to ethanol delayed and extended the period during which cortical neurons were generated, reduced the number of neurons in the nature cortex with the same time of origin, and altered the distribution of neurons generated on a particular day. Thus, the proliferation and migration of cortical neurons are profoundly affected by in utero exposure to ethanol.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Miller, M W -- AA 06916/AA/NIAAA NIH HHS/ -- New York, N.Y. -- Science. 1986 Sep 19;233(4770):1308-11.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3749878" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cerebral Cortex/*drug effects/embryology ; Ethanol/*pharmacology ; Female ; Gestational Age ; Humans ; Motor Cortex/drug effects/embryology ; Neurons/*drug effects/embryology ; Pregnancy ; Rats
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Mechanism of the rapid effect of 17 beta-estradiol on medial amygdala neurons (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-07-11
    Description: The mechanism by which sex steroids rapidly modulate the excitability of neurons was investigated by intracellular recording of neurons in rat medial amygdala brain slices. Brief hyperpolarization and increased potassium conductance were produced by 17 beta-estradiol. This effect persisted after elimination of synaptic input and after suppression of protein synthesis. Thus, 17 beta-estradiol directly changes the ionic conductance of the postsynaptic membrane of medial amygdala neurons. In addition, a greater proportion of the neurons from females than from males responded to 17 beta-estradiol.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nabekura, J -- Oomura, Y -- Minami, T -- Mizuno, Y -- Fukuda, A -- New York, N.Y. -- Science. 1986 Jul 11;233(4760):226-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3726531" target="_blank"〉PubMed〈/a〉
    Keywords: Amygdala/cytology/*drug effects ; Animals ; Cycloheximide/pharmacology ; Dactinomycin/pharmacology ; Estradiol/*pharmacology ; Female ; Male ; Membrane Potentials/drug effects ; Neurons/drug effects/physiology ; Rats ; Rats, Inbred Strains
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    Sex and needles, not insects and pigs, spread AIDS in Florida town (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-10-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Norman, C -- New York, N.Y. -- Science. 1986 Oct 24;234(4775):415-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3764417" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/classification/epidemiology/*transmission ; Arbovirus Infections/complications ; Female ; Humans ; Male
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Military AIDS testing offers research bonus (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-05-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Norman, C -- New York, N.Y. -- Science. 1986 May 16;232(4752):818-20.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3704628" target="_blank"〉PubMed〈/a〉
    Keywords: *Acquired Immunodeficiency Syndrome/transmission ; Female ; Humans ; Male ; Mass Screening ; *Military Medicine ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    A new twist in AIDS patent fight (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-04-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Norman, C -- New York, N.Y. -- Science. 1986 Apr 18;232(4748):308-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3008327" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/*microbiology ; *Deltaretrovirus/ultrastructure ; France ; Humans ; Microscopy, Electron ; *Patents as Topic ; United States
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    A plea from academia (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-01-31
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Norman, C -- New York, N.Y. -- Science. 1986 Jan 31;231(4737):447.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3941908" target="_blank"〉PubMed〈/a〉
    Keywords: National Institutes of Health (U.S.) ; Research Support as Topic/*economics ; United States ; Universities/*economics
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    Research on mental illness and addictive disorders (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-04-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pincus, H A -- New York, N.Y. -- Science. 1986 Apr 18;232(4748):307.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3008326" target="_blank"〉PubMed〈/a〉
    Keywords: *Mental Disorders ; National Institute of Mental Health (U.S.) ; National Institutes of Health (U.S.) ; Research ; *Substance-Related Disorders ; United States ; United States Substance Abuse and Mental Health Services Administration
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  • 53
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    AIDS in Africa: an epidemiologic paradigm (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-11-21
    Description: Cases of the acquired immune deficiency syndrome (AIDS) have been reported in countries throughout the world. Initial surveillance studies in Central Africa suggest an annual incidence of AIDS of 550 to 1000 cases per million adults. The male to female ratio of cases is 1:1, with age- and sex-specific rates greater in females less than 30 years of age and greater in males over age 40. Clinically, AIDS in Africans is often characterized by a diarrhea-wasting syndrome, opportunistic infections, such as tuberculosis, cryptococcosis, and cryptosporidiosis, or disseminated Kaposi's sarcoma. From 1 to 18% of healthy blood donors and pregnant women and as many as 27 to 88% of female prostitutes have antibodies to human immunodeficiency virus (HIV). The present annual incidence of infection is approximately 0.75% among the general population of Central and East Africa. The disease is transmitted predominantly by heterosexual activity, parenteral exposure to blood transfusions and unsterilized needles, and perinatally from infected mothers to their newborns, and will continue to spread rapidly where economic and cultural factors favor these modes of transmission. Prevention and control of HIV infection through educational programs and blood bank screening should be an immediate public health priority for all African countries.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Quinn, T C -- Mann, J M -- Curran, J W -- Piot, P -- New York, N.Y. -- Science. 1986 Nov 21;234(4779):955-63.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3022379" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/*epidemiology/history/transmission ; Africa ; Age Factors ; Antibodies, Viral/analysis ; Blood Transfusion ; Deltaretrovirus/immunology ; Female ; Forecasting ; Humans ; Injections, Intravenous ; Male ; Maternal-Fetal Exchange ; Opportunistic Infections/complications ; Pregnancy ; Prostitution ; Retroviridae/isolation & purification ; Risk ; Sarcoma, Kaposi/epidemiology ; Sex Factors ; Sexually Transmitted Diseases/epidemiology
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    Maleness pinpointed on Y chromosome (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-11-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G -- New York, N.Y. -- Science. 1986 Nov 28;234(4780):1076-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3775376" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Female ; H-Y Antigen/genetics ; Humans ; Lizards ; Male ; Mice ; *Sex Determination Analysis ; *Y Chromosome
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Soviets presented plans for Chernobyl study (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-08-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G -- New York, N.Y. -- Science. 1986 Aug 1;233(4763):513-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3523755" target="_blank"〉PubMed〈/a〉
    Keywords: *Accidents ; Bone Marrow Transplantation ; Ethics Committees, Clinical ; Ethics Committees, Research ; Federal Government ; *Government Regulation ; Humans ; International Cooperation ; Internationality ; National Institutes of Health (U.S.) ; *Nuclear Reactors ; Radiation Injuries/*therapy ; Ukraine ; United States
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    U.S. agencies may be shut out of Chernobyl follow-up (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-07-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G -- New York, N.Y. -- Science. 1986 Jul 11;233(4760):147.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3726525" target="_blank"〉PubMed〈/a〉
    Keywords: *Accidents ; Government Agencies ; Humans ; *Nuclear Reactors ; Radiation Injuries/etiology ; Ukraine ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    New blood test raises thorny issues (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-07-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G -- New York, N.Y. -- Science. 1986 Jul 11;233(4760):149-50.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3088724" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Blood Banks ; Blood Donors ; Hepatitis C/blood/*prevention & control ; Hepatitis, Viral, Human/*prevention & control ; Humans ; Pan troglodytes ; United States
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    Epidemiology of drug abuse: an overview (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-11-21
    Description: Issues regarding the use of epidemiology in drug abuse research are discussed and systems for monitoring national trends and identifying risk factors are described. Data indicate a general decline in marijuana use among youth, a cohort aging effect among heroin and marijuana users, and increased prevalence and health consequences associated with cocaine use.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kozel, N J -- Adams, E H -- New York, N.Y. -- Science. 1986 Nov 21;234(4779):970-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3490691" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/complications ; Adolescent ; Adult ; Child ; Cocaine ; Epidemiologic Methods ; Female ; Heroin ; Humans ; Male ; Marijuana Abuse/epidemiology ; Population Surveillance ; Risk ; Substance-Related Disorders/*epidemiology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 59
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    Stress-induced inhibition of reproductive functions: role of endogenous corticotropin-releasing factor (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-02-07
    Description: In the adult castrated male rat, exposure to inescapable, intermittent electroshocks inhibited the pulsatile pattern of luteinizing hormone release and markedly lowered its plasma concentrations. The central administration of the corticotropin-releasing factor (CRF) antagonist alpha-helical ovine CRF residues 9 to 41 reversed the inhibitory action of stress. Neither its peripheral injection, nor the intraventricular injection of the inactive CRF analog des-Glu to Arg ovine CRF was effective. These results suggest that endogenous CRF may mediate some deleterious effects of noxious stimuli on reproduction.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rivier, C -- Rivier, J -- Vale, W -- AA03504/AA/NIAAA NIH HHS/ -- AM26741/AM/NIADDK NIH HHS/ -- HD13527/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1986 Feb 7;231(4738):607-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3003907" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenocorticotropic Hormone/physiology ; Animals ; Corticotropin-Releasing Hormone/pharmacology/*physiology ; Electroshock ; Female ; Humans ; Luteinizing Hormone/blood ; Male ; Orchiectomy ; Rats ; *Reproduction/drug effects ; Stress, Psychological/*physiopathology
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    Adrenal-mediated endogenous metabolites inhibit puberty in female mice (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-02-14
    Description: While assessing a potential role of adrenal glands in the production of the hitherto unidentified puberty-delaying pheromone of female mice, the urinary volatile profiles of normal and adrenalectomized animals were quantitatively compared. Six components, whose concentrations were depressed after adrenalectomy, were identified: 2-heptanone, trans-5-hepten-2-one, trans-4-hepten-2-one, n-pentyl acetate, cis-2-penten-1-yl acetate, and 2,5-dimethylpyrazine. When these laboratory-synthesized chemicals were added (in their natural concentrations) to either previously inactive urine from adrenalectomized females or plain water, the biological activity was fully restored.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Novotny, M -- Jemiolo, B -- Harvey, S -- Wiesler, D -- Marchlewska-Koj, A -- New York, N.Y. -- Science. 1986 Feb 14;231(4739):722-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3945805" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenal Glands/*physiology ; Animals ; Female ; Ketones/urine ; Mice ; Ovary/physiology ; Pentanols/urine ; Pheromones/physiology/urine ; Pyrazines/urine ; *Sexual Maturation
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    AIDS patent negotiations break down (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-05-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Norman, C -- New York, N.Y. -- Science. 1986 May 16;232(4752):819.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3010454" target="_blank"〉PubMed〈/a〉
    Keywords: *Acquired Immunodeficiency Syndrome/immunology/microbiology ; Antibodies, Viral/immunology ; Deltaretrovirus/immunology ; France ; Humans ; *Patents as Topic ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Biotech firm gets another black eye over experiment (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-03-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, Marjorie -- New York, N.Y. -- Science. 1986 Mar 14;231(4743):1242.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11643907" target="_blank"〉PubMed〈/a〉
    Keywords: *DNA, Recombinant ; *Ecology ; Federal Government ; Government ; *Government Regulation ; *Industry ; Jurisprudence ; Microbiology ; Politics ; Public Policy ; Risk ; Risk Assessment ; *Social Control, Formal ; United States ; United States Environmental Protection Agency
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 63
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    Formaldehyde poses little risk, study says (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-03-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1986 Mar 21;231(4744):1365.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3952489" target="_blank"〉PubMed〈/a〉
    Keywords: Environmental Exposure ; Formaldehyde/*adverse effects ; Humans ; Lung Neoplasms/chemically induced ; National Institutes of Health (U.S.) ; United States ; United States Occupational Safety and Health Administration
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 64
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    Shock and tissue injury induced by recombinant human cachectin (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-10-24
    Description: Cachectin (tumor necrosis factor), a protein produced in large quantities by endotoxin-activated macrophages, has been implicated as an important mediator of the lethal effect of endotoxin. Recombinant human cachectin was infused into rats in an effort to determine whether cachectin, by itself, can elicit the derangements of host physiology caused by administration of endotoxin. When administered in quantities similar to those produced endogenously in response to endotoxin, cachectin causes hypotension, metabolic acidosis, hemoconcentration, and death within minutes to hours, as a result of respiratory arrest. Hyperglycemia and hyperkalemia were also observed after infusion. At necropsy, diffuse pulmonary inflammation and hemorrhage were apparent on gross and histopathologic examination, along with ischemic and hemorrhagic lesions of the gastrointestinal tract, and acute renal tubular necrosis. Thus, it appears that a single protein mediator (cachectin) is capable of inducing many of the deleterious effects of endotoxin.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tracey, K J -- Beutler, B -- Lowry, S F -- Merryweather, J -- Wolpe, S -- Milsark, I W -- Hariri, R J -- Fahey, T J 3rd -- Zentella, A -- Albert, J D -- New York, N.Y. -- Science. 1986 Oct 24;234(4775):470-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3764421" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blood Glucose/metabolism ; Endotoxins/toxicity ; Female ; Glycoproteins/*toxicity ; Humans ; Potassium/blood ; Rats ; Recombinant Proteins ; Shock/*chemically induced/pathology/physiopathology ; Sodium/blood ; Tumor Necrosis Factor-alpha
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Biotech guidelines challenged by Rifkin (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-08-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, Marjorie -- New York, N.Y. -- Science. 1986 Aug 1;233(4763):516.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11643926" target="_blank"〉PubMed〈/a〉
    Keywords: Advisory Committees ; *DNA, Recombinant ; *Ecology ; Federal Government ; Government ; *Government Regulation ; Jurisprudence ; Politics ; *Public Policy ; *Social Control, Formal ; United States ; United States Environmental Protection Agency
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    EPA proposal on alachlor nears (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-09-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1986 Sep 12;233(4769):1143-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3738527" target="_blank"〉PubMed〈/a〉
    Keywords: Acetamides/*adverse effects ; Animals ; *Government Agencies ; Herbicides/*adverse effects ; Humans ; Neoplasms/chemically induced ; Rats ; United States ; *United States Environmental Protection Agency
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Florida physician to be Assistant Secretary for Health (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-07-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1986 Jul 4;233(4759):22.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3520821" target="_blank"〉PubMed〈/a〉
    Keywords: History, 20th Century ; United States ; United States Public Health Service/*organization & administration
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    White House to release biotechnology guidelines (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-06-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, Marjorie -- New York, N.Y. -- Science. 1986 Jun 6;232(4755):1189.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11643922" target="_blank"〉PubMed〈/a〉
    Keywords: Advisory Committees ; Containment of Biohazards ; *DNA, Recombinant ; Drug-Related Side Effects and Adverse Reactions ; *Ecology ; Federal Government ; Government ; *Government Regulation ; Guidelines as Topic ; Industry ; Microbiology ; National Institutes of Health (U.S.) ; *Public Policy ; Reference Standards ; *Social Control, Formal ; United States ; United States Environmental Protection Agency
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 69
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    USDA biotechnology review criticized and defended (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-04-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, Marjorie -- New York, N.Y. -- Science. 1986 Apr 18;232(4748):316.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11643917" target="_blank"〉PubMed〈/a〉
    Keywords: *DNA, Recombinant ; Ecology ; *Federal Government ; *Government ; *Government Regulation ; Industry ; Microbiology ; Politics ; Public Policy ; *Social Control, Formal ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    EPA suspends biotech permit (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-04-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1986 Apr 4;232(4746):15.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3456642" target="_blank"〉PubMed〈/a〉
    Keywords: *Agriculture ; Bacteria/genetics ; *Genetic Engineering ; *Government Agencies ; United States ; *United States Environmental Protection Agency
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 71
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    Male-killing bacteria in a parasitic wasp (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-02-28
    Description: A rod-shaped bacterium has been isolated that kills male eggs of the wasp Nasonia vitripennis, a pupal parasite of flies. Only some wasps of this species express this son-killer trait, and these wasps have bacterial infections in various organs. The bacterium was isolated from son-killer wasp tissue and from the hemolymph of fly pupae parasitized by wasps expressing the son-killer trait. Bacteria are apparently transferred to parasitized fly pupae during wasp oviposition, and developing wasp offspring are subsequently infected perorally. Sex-ratio distortion by microorganisms is found in a variety of plants and animals. The infectious peroral transmission of this trait variety of plants and animals. The infectious peroral transmission of this trait is in contrast to the typical pattern of cytoplasmic inheritance of sex-ratio distortion in these other systems.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Werren, J H -- Skinner, S W -- Huger, A M -- 5 T32 6MO7131/PHS HHS/ -- New York, N.Y. -- Science. 1986 Feb 28;231(4741):990-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3945814" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bacteria ; Female ; Hemolymph/microbiology ; Hymenoptera/*microbiology ; Male ; Ovum/microbiology ; Sex Factors ; Wasps/*microbiology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Alterations of myc, myb, and rasHa proto-oncogenes in cancers are frequent and show clinical correlation (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-01-17
    Description: Alterations of c-myc, c-rasHa, or c-myb oncogenes were found in more than one-third of human solid tumors. Amplification of c-myc occurred in advanced, widespread tumors or in aggressive primary tumors. Apparent allelic deletions of c-rasHa and c-myb can be correlated with progression and metastasis of carcinomas and sarcomas.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yokota, J -- Tsunetsugu-Yokota, Y -- Battifora, H -- Le Fevre, C -- Cline, M J -- CA15619/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1986 Jan 17;231(4735):261-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3941898" target="_blank"〉PubMed〈/a〉
    Keywords: Alleles ; Child ; DNA, Neoplasm/genetics/isolation & purification ; Female ; Humans ; Leukemia/genetics ; Male ; Middle Aged ; Neoplasms/*genetics ; Oncogenes ; Phenotype ; Polymorphism, Genetic ; *Proto-Oncogenes ; Sarcoma/genetics ; Transcription, Genetic
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Biotechnology regulation (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-09-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Miller, H I -- Young, F E -- New York, N.Y. -- Science. 1986 Sep 12;233(4769):1135-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3461563" target="_blank"〉PubMed〈/a〉
    Keywords: *Genetic Engineering ; *Legislation as Topic ; United States ; United States Food and Drug Administration
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 74
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    AIDS in Africa (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-01-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Linke, U -- New York, N.Y. -- Science. 1986 Jan 17;231(4735):203.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3941894" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/epidemiology/*transmission ; Circumcision, Male ; Female ; Humans ; Male ; Sexual Behavior
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 75
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    Distribution of airborne radon-222 concentrations in U.S. homes (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-11-21
    Description: Apparently large exposures of the general public to the radioactive decay products of radon-222 present in indoor air have led to systematical appraisal of monitoring data from U.S. single-family homes; several ways of aggregating data were used that take into account differences in sample selection and season of measurements. The resulting distribution of annual-average radon-222 concentrations can be characterized by an arithmetic mean of 1.5 picocurie per liter (55 becquerels per cubic meter) and a long tail with 1 to 3% of homes exceeding 8 picocuries per liter, or by a geometric mean of 0.9 picocurie per liter and a geometric standard deviation of about 2.8. The standard deviation in the means is 15%, estimated from the number and variability of the available data sets, but the total uncertainty is larger because these data may not be representative. Available dose-response data suggest that an average of 1.5 picocuries per liter contributes about 0.3% lifetime risk of lung cancer and that, in the million homes with the highest concentrations, where annual exposures approximate or exceed those received by underground uranium miners, long-term occupants suffer an added lifetime risk of at least 2%, reaching extraordinary values at the highest concentrations observed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nero, A V -- Schwehr, M B -- Nazaroff, W W -- Revzan, K L -- New York, N.Y. -- Science. 1986 Nov 21;234(4779):992-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3775373" target="_blank"〉PubMed〈/a〉
    Keywords: *Air Pollutants ; *Air Pollutants, Radioactive ; Lung Neoplasms/etiology ; Neoplasms, Radiation-Induced ; *Radon/analysis ; Seasons ; United States
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    Deficits haunt science budgets (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-08-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Norman, C -- New York, N.Y. -- Science. 1986 Aug 29;233(4767):927-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3738515" target="_blank"〉PubMed〈/a〉
    Keywords: Budgets ; Government Agencies ; *Legislation as Topic ; National Institutes of Health (U.S.) ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 77
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    OMB floats new indirect cost plan (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-06-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Norman, C -- New York, N.Y. -- Science. 1986 Jun 20;232(4757):1494-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3715455" target="_blank"〉PubMed〈/a〉
    Keywords: *Government Agencies ; *Research Support as Topic ; United States ; Universities/*economics
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Virus-associated cancers can be a major problem in the tropics (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-02-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J L -- New York, N.Y. -- Science. 1986 Feb 28;231(4741):919.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3945813" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; China ; Female ; Humans ; Neoplasms/*microbiology ; *Tropical Medicine
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Risk research: when should we say "enough"? (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-05-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Morgan, M G -- New York, N.Y. -- Science. 1986 May 23;232(4753):917.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3704631" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; *Probability ; Research Support as Topic ; *Risk ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 80
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    Ground water ills: many diagnoses, few remedies (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-06-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1986 Jun 20;232(4757):1490-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3012777" target="_blank"〉PubMed〈/a〉
    Keywords: Agriculture ; Fertilizers/analysis ; Pesticides/analysis ; United States ; Water Pollution, Chemical/*prevention & control ; Water Supply
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 81
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    NIH plans probe on test of altered virus (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-05-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1986 May 16;232(4752):821-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3704629" target="_blank"〉PubMed〈/a〉
    Keywords: Advisory Committees ; Animal Experimentation ; Animals ; Federal Government ; *Government Regulation ; *National Institutes of Health (U.S.) ; Pseudorabies/immunology/*prevention & control ; Swine ; Swine Diseases/*prevention & control ; United States ; Viral Vaccines/*therapeutic use
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 82
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    USDA suspends license for engineered vaccine (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-04-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1986 Apr 25;232(4749):446.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3457469" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Federal Government ; *Genetic Engineering ; Government Agencies ; *Government Regulation ; United States ; *Vaccines
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 83
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    Antagonists agree on pesticide law reform (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-04-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1986 Apr 4;232(4746):16-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3952498" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; *Legislation, Drug ; Pesticides/*standards ; Risk ; Safety ; United States ; United States Environmental Protection Agency
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 84
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    Federal VDT study finally wins approval (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-06-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1986 Jun 27;232(4758):1594-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3715463" target="_blank"〉PubMed〈/a〉
    Keywords: *Data Display ; Female ; Humans ; National Institute for Occupational Safety and Health (U.S.) ; Pregnancy ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 85
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    Bioavailability of dioxin in soil from a 2,4,5-T manufacturing site (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-04-25
    Description: Dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin, TCDD) is a highly toxic contaminant produced in the manufacture of phenoxy herbicides. Despite its high TCDD content, soil from a contaminated area associated with a 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) manufacturing site in Newark, New Jersey, did not induce acute toxicity when administered to guinea pigs (the most sensitive species) by gavage. Analysis of liver samples demonstrated low bioavailability of TCDD from this soil. A comparative analysis of soils showed that Soxhlet extraction was necessary for the determination of TCDD on Newark soil, whereas solvent extraction was sufficient for soil from Times Beach, Missouri. The difference in the bioavailability of TCDD from these soils is correlated with TCDD extractability and may be related to the different compositions of the soils.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Umbreit, T H -- Hesse, E J -- Gallo, M A -- New York, N.Y. -- Science. 1986 Apr 25;232(4749):497-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3961492" target="_blank"〉PubMed〈/a〉
    Keywords: 2,4,5-Trichlorophenoxyacetic Acid/*chemical synthesis ; Animals ; Benzofurans/analysis ; Biological Availability ; *Chemical Industry ; Dioxins/analysis/*metabolism ; Female ; Guinea Pigs ; Male ; New Jersey ; Soil/analysis ; *Soil Pollutants/analysis ; Tetrachlorodibenzodioxin/analysis/*metabolism/toxicity
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 86
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    Scienceless to homeless (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-12-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wyatt, R J -- DeRenzo, E G -- New York, N.Y. -- Science. 1986 Dec 12;234(4782):1309.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3787247" target="_blank"〉PubMed〈/a〉
    Keywords: Deinstitutionalization ; *Homeless Persons ; Humans ; *Public Policy ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 87
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    The M.D. class of '86: smaller, deeper in debt (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-10-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Walsh, J -- New York, N.Y. -- Science. 1986 Oct 3;234(4772):21.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3749890" target="_blank"〉PubMed〈/a〉
    Keywords: Education, Medical/economics ; Physicians/*economics ; *Training Support ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 88
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    Shifting sentiments over sequencing the human genome (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-08-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lewin, R -- New York, N.Y. -- Science. 1986 Aug 8;233(4764):620-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3726552" target="_blank"〉PubMed〈/a〉
    Keywords: *Base Sequence ; *Chromosomes, Human ; Humans ; National Institutes of Health (U.S.) ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 89
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    OMB and congress at odds over cancer risk policy (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-08-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1986 Aug 8;233(4764):618.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3726550" target="_blank"〉PubMed〈/a〉
    Keywords: *Government Agencies ; Humans ; *Neoplasms ; Risk ; United States ; United States Environmental Protection Agency
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 90
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    Yellow rain evidence slowly whittled away (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-07-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1986 Jul 4;233(4759):18-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3715471" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Asia, Southeastern ; Bees ; *Chemical Warfare ; Feces ; Humans ; Ussr ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 91
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    Human papilloma virus and cervical cancer (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-02-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J L -- New York, N.Y. -- Science. 1986 Feb 28;231(4741):920.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3003916" target="_blank"〉PubMed〈/a〉
    Keywords: Bovine papillomavirus 1/genetics ; DNA, Viral/genetics ; Female ; Humans ; *Papillomaviridae/genetics ; Tumor Virus Infections/microbiology ; Uterine Cervical Neoplasms/*microbiology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 92
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    Induction of suppressor cells specific for AChR in experimental autoimmune myasthenia gravis (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-04-18
    Description: Suppressor cells specific for acetylcholine receptor (AChR) were induced in a population of lymphocytes previously sensitized to AChR, obtained from rats with experimental autoimmune myasthenia gravis (EAMG). The lymphocytes were cultured with the immunosuppressive drug cyclosporin A plus purified AChR for 7 days. These cells, when mixed with lymphocytes from rats with EAMG in vitro, strongly suppressed the antibody response to AChR. They did not inhibit antibody responses to an unrelated antigen, an indication that suppression was specific for AChR. This approach should be a useful way to induce specific suppressor cells from sensitized populations of lymphocytes and may be applicable in the treatment of autoimmune diseases such as myasthenia gravis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McIntosh, K R -- Drachman, D B -- 5RO1 HD04817-16/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1986 Apr 18;232(4748):401-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2938256" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cyclosporins/pharmacology ; Female ; Lymph Nodes/cytology ; Lymphocytes/drug effects ; Myasthenia Gravis/*immunology ; Rats ; Rats, Inbred Lew ; Receptors, Cholinergic/*immunology ; Spleen/cytology ; T-Lymphocytes, Regulatory/*immunology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 93
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    Pressures measured in live hip joint (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-06-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lewin, R -- New York, N.Y. -- Science. 1986 Jun 6;232(4755):1192-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3704643" target="_blank"〉PubMed〈/a〉
    Keywords: Aged ; Female ; Hip Joint/*physiology ; Hip Prosthesis ; Humans ; Muscle Contraction ; Pressure
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  • 94
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    The 1985 Nobel Prize in physiology or medicine (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-01-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Motulsky, A G -- New York, N.Y. -- Science. 1986 Jan 10;231(4734):126-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3510453" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Arteriosclerosis/therapy ; Cholesterol/blood/metabolism ; Endocytosis ; History, 20th Century ; Humans ; Hyperlipoproteinemia Type II/genetics/therapy ; Lipoproteins/metabolism ; Male ; Middle Aged ; Mutation ; *Nobel Prize ; Receptors, LDL/genetics ; United States
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  • 95
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    Pancreatic zymogen granules differ markedly in protein composition (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-05-16
    Description: The activities of both chymotrypsin and amylase in individual zymogen granules of rat pancreas were measured by means of micromanipulation and microfluorometric methods. The enzyme content and the ratio of amylase to chymotrypsin varied widely among granules taken from the same animal. These results are compatible with short-term nonparallel bulk secretion of the two enzymes through exocytosis. The distribution of each enzyme activity in a population of granules suggests quantal packaging of amylase and chymotrypsinogen into the granules.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mroz, E A -- Lechene, C -- AM26488/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1986 May 16;232(4752):871-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2422756" target="_blank"〉PubMed〈/a〉
    Keywords: Amylases/*analysis ; Animals ; Chymotrypsin/*analysis ; Cytoplasmic Granules/*analysis ; Exocytosis ; Female ; Pancreas/*secretion ; Rats ; Rats, Inbred Strains
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  • 96
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    Inhibin-mediated feedback control of follicle-stimulating hormone secretion in the female rat (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-10-10
    Description: The secretion of follicle-stimulating hormone (FSH) by the anterior pituitary gland is regulated by the interaction of hypothalamic and gonadal hormones. Recently, proteins termed inhibins that selectively suppress FSH secretion have been purified and characterized from the gonadal fluids of several species. Antibodies to a synthetic peptide encompassing the amino terminal 25 residues of the recently characterized porcine inhibin were used to develop a specific radioimmunoassay (RIA) for inhibin and to neutralize endogenous inhibin during the estrous cycle of the rat. The administration of 20 international units of pregnant mare serum gonadotropin (PMSG) stimulated the secretion of inhibin in intact immature female rats, whereas ovariectomy caused an abrupt decrease in plasma inhibin concentrations that were not prevented by the injection of PMSG. The infusion of a polyclonal antiserum to inhibin, from 12 noon on proestrus to 1 a.m. on the morning of estrus, as well as its acute intravenous injection during diestrus I or II, caused an increase in plasma FSH (but not luteinizing hormone) concentrations. These results support the hypothesis of a feedback loop between the release of ovarian inhibin and FSH in the female rat.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rivier, C -- Rivier, J -- Vale, W -- HD13527/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1986 Oct 10;234(4773):205-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3092356" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Estrus ; Female ; Follicle Stimulating Hormone/blood/*secretion ; Gonadotropins, Equine/pharmacology ; Immune Sera ; Inhibins/blood/immunology/*secretion ; Luteinizing Hormone/blood ; Ovariectomy ; Proestrus ; Rats ; Rats, Inbred Strains
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  • 97
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    The lessons of Chernobyl (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-09-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1986 Sep 26;233(4771):1375-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3749881" target="_blank"〉PubMed〈/a〉
    Keywords: Accident Prevention ; *Accidents ; Humans ; *Nuclear Reactors ; Ukraine ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 98
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    A balanced translocation in mice with a neurological defect (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-01-24
    Description: A semisterile male translocation heterozygote [t(2; 14) 1Gso] that exhibited neurological symptoms and an inability to swim (diver) was found among the offspring of male mice treated with triethylenemelamine. All breeding and cytogenetic data showed a complete concordance between translocation heterozygosity and the neurological disorders. Homozygosity for the translocation seemed to be lethal at an early embryonic stage. Despite the distinctive neurologic symptoms, no anatomic or histological defects in either the ear or in the central nervous system were observed. Thus, a balanced chromosomal translocation can produce disease with an inheritance pattern that mimics a single dominant gene defect.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rutledge, J C -- Cain, K T -- Cacheiro, N L -- Cornett, C V -- Wright, C G -- Generoso, W M -- New York, N.Y. -- Science. 1986 Jan 24;231(4736):395-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3941902" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chromosome Mapping ; Female ; Heterozygote ; Humans ; Male ; Mice ; Mice, Inbred C3H ; Mice, Inbred C57BL ; Mice, Neurologic Mutants/*genetics ; Muscular Dystrophies/genetics ; *Translocation, Genetic ; Triethylenemelamine/pharmacology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 99
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    Who should have rights to a patient's cells? (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-02-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1986 Feb 7;231(4738):543-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3945799" target="_blank"〉PubMed〈/a〉
    Keywords: *Biomedical Research ; *Cell Line ; Ethics, Medical ; Federal Government ; Female ; *Human Body ; Humans ; *Jurisprudence ; *Patient Rights ; *Tissue and Organ Procurement ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 100
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    Study estimates higher risk from ethylene oxide exposure (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-01-31
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1986 Jan 31;231(4737):448.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3941909" target="_blank"〉PubMed〈/a〉
    Keywords: Air Pollutants, Occupational/*toxicity ; Animals ; Ethylene Oxide/*toxicity ; Female ; Humans ; Male ; Mice ; Pregnancy ; Risk ; *Teratogens ; United States ; United States Occupational Safety and Health Administration
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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