Publikationsdatum:
1997-01-17
Beschreibung:
Familial combined hyperlipidemia (FCHL) is a common inherited lipid disorder, affecting 1 to 2 percent of the population in Westernized societies. Individuals with FCHL have large quantities of very low density lipoprotein (VLDL) and low density lipoprotein (LDL) and develop premature coronary heart disease. A mouse model displaying some of the features of FCHL was created by crossing mice carrying the human apolipoprotein C-III (APOC3) transgene with mice deficient in the LDL receptor. A synergistic interaction between the apolipoprotein C-III and the LDL receptor defects produced large quantities of VLDL and LDL and enhanced the development of atherosclerosis. This mouse model may provide clues to the origin of human FCHL.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Masucci-Magoulas, L -- Goldberg, I J -- Bisgaier, C L -- Serajuddin, H -- Francone, O L -- Breslow, J L -- Tall, A R -- HL 21006/HL/NHLBI NIH HHS/ -- HL 54591/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1997 Jan 17;275(5298):391-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine, Columbia University, 630 West 168 Street, New York, NY 10032, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8994037" target="_blank"〉PubMed〈/a〉
Schlagwort(e):
Animals
;
Apolipoprotein C-III
;
Apolipoproteins B/blood
;
Apolipoproteins C/*genetics
;
Apolipoproteins E/blood
;
Arteriosclerosis/etiology
;
Carrier Proteins/genetics
;
Cholesterol/blood
;
Cholesterol Ester Transfer Proteins
;
Cholesterol, HDL/blood
;
Cholesterol, LDL/blood
;
Cholesterol, VLDL/blood
;
Diet
;
*Disease Models, Animal
;
Disease Susceptibility
;
Female
;
*Glycoproteins
;
Humans
;
*Hyperlipidemia, Familial Combined/blood/genetics
;
Hyperlipoproteinemia Type IV/genetics
;
Lipoproteins/blood
;
Lipoproteins, VLDL/blood
;
Male
;
Mice
;
Mice, Inbred C57BL
;
*Mice, Transgenic
;
Receptors, LDL/*genetics/metabolism
;
Transgenes
;
Triglycerides/blood
Print ISSN:
0036-8075
Digitale ISSN:
1095-9203
Thema:
Biologie
,
Chemie und Pharmazie
,
Informatik
,
Medizin
,
Allgemeine Naturwissenschaft
,
Physik
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