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  • Base Sequence  (74)
  • Cells, Cultured  (33)
  • American Association for the Advancement of Science (AAAS)  (105)
  • Annual Reviews
  • 1980-1984  (105)
  • 1930-1934
  • 1984  (105)
Collection
Keywords
Publisher
  • American Association for the Advancement of Science (AAAS)  (105)
  • Annual Reviews
Years
  • 1980-1984  (105)
  • 1930-1934
Year
  • 101
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    Biological activity of recombinant human interleukin-2 produced in Escherichia coli (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-03-30
    Description: The gene for interleukin-2 was isolated from the Jurkat cell line and from normal peripheral blood lymphocytes and, when inserted in Escherichia coli, was expressed at high concentrations. This interleukin-2 was purified to apparent homogeneity and tested for biological activity in a variety of assays in vitro and in vivo. The recombinant lymphokine supports the growth of murine and human interleukin-2 dependent cell lines, enhances the generation of murine and human cytolytic cells in vitro, and generates lymphokine activated killer cells from murine and human lymphocytes. It has a serum half-life of 2 to 3 minutes in the mouse and significantly enhances the generation of cytolytic cells in vivo after alloimmunization. No functional differences between native and the recombinant interleukin-2 molecules have been detected.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rosenberg, S A -- Grimm, E A -- McGrogan, M -- Doyle, M -- Kawasaki, E -- Koths, K -- Mark, D F -- New York, N.Y. -- Science. 1984 Mar 30;223(4643):1412-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6367046" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Cell Line ; DNA, Recombinant/metabolism ; Escherichia coli/*metabolism ; Humans ; Interleukin-2/biosynthesis/*genetics/physiology ; Killer Cells, Natural/physiology ; Lymphocytes/physiology ; Mice ; Mice, Inbred C57BL ; *Recombination, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 102
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    Identification of an infective stage of Leishmania promastigotes (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-03-30
    Description: Sequential development of Leishmania promastigotes from a noninfective to an infective stage was demonstrated for promastigotes growing in culture and in the sandfly vector. The generation of an infective stage was found to be growth cycle-dependent and restricted to nondividing organisms.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sacks, D L -- Perkins, P V -- New York, N.Y. -- Science. 1984 Mar 30;223(4643):1417-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6701528" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cells, Cultured ; Insect Vectors/parasitology ; Leishmania/growth & development/*physiology ; Leishmaniasis/parasitology/transmission ; Macrophages/parasitology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Psychodidae/parasitology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 103
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    Malignant activation of a K-ras oncogene in lung carcinoma but not in normal tissue of the same patient (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-02-17
    Description: A single genetic alteration, a guanine-to-cytosine transversion, is responsible for the acquisition of malignant properties by K-ras genes of two human tumor cell lines established from carcinomas of the bladder (A1698) and lung (A2182). As a consequence, arginine instead of the normal glycine is incorporated into the K-ras-coded p21 proteins at amino acid position 12. This mutation creates a restriction enzyme polymorphism that can be used to screen human cells for transforming K-ras genes. This approach was used to identify the mutational event responsible for the malignant activation of a K-ras oncogene in a squamous cell lung carcinoma of a 66-year-old man; this point mutation was not present in either the normal bronchial or parenchymal tissue or in the blood lymphocytes. Hence, malignant activation of a ras oncogene appears to be specifically associated with the development of a human neoplasm.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Santos, E -- Martin-Zanca, D -- Reddy, E P -- Pierotti, M A -- Della Porta, G -- Barbacid, M -- New York, N.Y. -- Science. 1984 Feb 17;223(4637):661-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6695174" target="_blank"〉PubMed〈/a〉
    Keywords: Base Sequence ; *Cell Transformation, Neoplastic ; DNA, Neoplasm/genetics ; Genes, Dominant ; Humans ; Lung Neoplasms/*genetics ; Mutation ; *Oncogenes ; Organ Specificity ; Polymorphism, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 104
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    Sequence of the human somatostatin I gene (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-04-13
    Description: Two human genomic DNA fragments containing alleles for the gene coding for somatostatin I were isolated and sequenced. This gene contains a single intron that interrupts the coding sequence in the propeptide portion of the somatostatin moiety. The site of initiation of transcription of the gene was located by transcription experiments in HeLa cell extracts, and the putative regions for controlling the initiation of transcription were identified.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shen, L P -- Rutter, W J -- AM 21344/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1984 Apr 13;224(4645):168-71.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6142531" target="_blank"〉PubMed〈/a〉
    Keywords: Alleles ; Base Sequence ; Cloning, Molecular ; DNA/*genetics/isolation & purification ; Genes ; Humans ; Nucleic Acid Hybridization ; Somatostatin/*genetics ; Transcription, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 105
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    Association of parvoviruses with rheumatoid arthritis of humans (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-03-30
    Description: A small virus resembling parvoviruses in its morphological and physicochemical properties was derived from synovial tissue of a patient with severe rheumatoid arthritis. This virus, designated RA-1, elicits a syndrome in neonatal mice that includes neurological disturbances, permanent crippling of limbs, dwarfism, alopecia, blepharitis, "masking," and a rigid curvature of the thoracic spine. Polyclonal antibodies against RA-1 display high virus neutralizing activity and in immunoassays detect reactive antigen in synovial cells from different rheumatoid arthritis patients but not persons with osteoarthritis. Putative parvoviruses isolated from several other rheumatoid arthritis patients are only weakly pathogenic for newborn mice but can generate RA-1 virus-specific antigens in tissues of these animals. It has not been established that RA-1 and existing parvoviruses of mammalian species are related.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Simpson, R W -- McGinty, L -- Simon, L -- Smith, C A -- Godzeski, C W -- Boyd, R J -- AI-14359/AI/NIAID NIH HHS/ -- AI-17262/AI/NIAID NIH HHS/ -- AM-15796/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1984 Mar 30;223(4643):1425-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6701529" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Newborn/microbiology ; Antibodies, Viral/immunology ; Arthritis, Rheumatoid/*microbiology ; Cells, Cultured ; Enzyme-Linked Immunosorbent Assay ; Humans ; Mice ; Microscopy, Electron ; Osteoarthritis/microbiology ; Parvoviridae/immunology/*isolation & purification/ultrastructure ; Rabbits ; Synovial Fluid/cytology/microbiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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