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  • Articles  (30)
  • Drosophila melanogaster
  • metoprolol
  • Springer  (24)
  • American Association for the Advancement of Science (AAAS)  (6)
  • American Chemical Society
  • American Chemical Society (ACS)
  • American Geophysical Union
  • Institute of Electrical and Electronics Engineers (IEEE)
  • National Academy of Sciences
  • Nature Publishing Group
  • 2015-2019
  • 2005-2009  (4)
  • 1990-1994
  • 1980-1984  (26)
  • 2019
  • 2017
  • 2009  (4)
  • 1983  (26)
  • Chemistry and Pharmacology  (30)
  • Computer Science  (6)
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  • Articles  (30)
Source
Keywords
Publisher
  • Springer  (24)
  • American Association for the Advancement of Science (AAAS)  (6)
  • American Chemical Society
  • American Chemical Society (ACS)
  • American Geophysical Union
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Years
  • 2015-2019
  • 2005-2009  (4)
  • 1990-1994
  • 1980-1984  (26)
Year
Journal
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  • 1
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    Cell biology. The ABCs of lipophile transport (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-02-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hla, Timothy -- Im, Dong-Soon -- New York, N.Y. -- Science. 2009 Feb 13;323(5916):883-4. doi: 10.1126/science.1170009.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Vascular Biology, University of Connecticut Health Center, Farmington, CT 06030, USA. hla@nso2.uchc.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19213902" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Transport ; Carrier Proteins/*physiology ; Chemotaxis/*physiology ; Drosophila Proteins/*physiology ; Drosophila melanogaster ; Germ Cells/physiology ; Heart/embryology ; Lipids ; Lysophospholipids/metabolism ; Membrane Proteins/*physiology ; P-Glycoproteins/*physiology ; Sphingosine/analogs & derivatives/metabolism ; Zebrafish ; Zebrafish Proteins/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    An ABC transporter controls export of a Drosophila germ cell attractant (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-02-14
    Description: Directed cell migration, which is critical for embryonic development, leukocyte trafficking, and cell metastasis, depends on chemoattraction. 3-hydroxy-3-methylglutaryl coenzyme A reductase regulates the production of an attractant for Drosophila germ cells that may itself be geranylated. Chemoattractants are commonly secreted through a classical, signal peptide-dependent pathway, but a geranyl-modified attractant would require an alternative pathway. In budding yeast, pheromones produced by a-cells are farnesylated and secreted in a signal peptide-independent manner, requiring the adenosine triphosphate-binding cassette (ABC) transporter Ste6p. Here we show that Drosophila germ cell migration uses a similar pathway, demonstrating that invertebrate germ cells, like yeast cells, are attracted to lipid-modified peptides. Components of this unconventional export pathway are highly conserved, suggesting that this pathway may control the production of similarly modified chemoattractants in organisms ranging from yeast to humans.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2729540/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2729540/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ricardo, Sara -- Lehmann, Ruth -- HD49100/HD/NICHD NIH HHS/ -- R01 HD041900/HD/NICHD NIH HHS/ -- R01 HD041900-08/HD/NICHD NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2009 Feb 13;323(5916):943-6. doi: 10.1126/science.1166239.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Helen L. and Martin S. Kimmel Center for Biology and Medicine at the Skirball Institute, Department of Cell Biology, New York University School of Medicine, New York University, 540 First Avenue, New York, NY 10016, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19213920" target="_blank"〉PubMed〈/a〉
    Keywords: ATP-Binding Cassette Transporters/genetics/metabolism ; Animals ; Biological Transport ; Chemotaxis/*physiology ; Diterpenes/metabolism ; Drosophila Proteins/genetics/metabolism/*physiology ; Drosophila melanogaster ; Genetic Complementation Test ; Germ Cells/*physiology ; Hydroxymethylglutaryl CoA Reductases/metabolism ; Mesoderm/cytology/metabolism ; P-Glycoproteins/genetics/metabolism/*physiology ; Protein Prenylation ; Protein Sorting Signals ; Saccharomyces cerevisiae Proteins/genetics/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    Global analysis of short RNAs reveals widespread promoter-proximal stalling and arrest of Pol II in Drosophila (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-12-17
    Description: Emerging evidence indicates that gene expression in higher organisms is regulated by RNA polymerase II stalling during early transcription elongation. To probe the mechanisms responsible for this regulation, we developed methods to isolate and characterize short RNAs derived from stalled RNA polymerase II in Drosophila cells. Significant levels of these short RNAs were generated from more than one-third of all genes, indicating that promoter-proximal stalling is a general feature of early polymerase elongation. Nucleotide composition of the initially transcribed sequence played an important role in promoting transcriptional stalling by rendering polymerase elongation complexes highly susceptible to backtracking and arrest. These results indicate that the intrinsic efficiency of early elongation can greatly affect gene expression.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3435875/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3435875/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nechaev, Sergei -- Fargo, David C -- dos Santos, Gilberto -- Liu, Liwen -- Gao, Yuan -- Adelman, Karen -- ZIA ES101987-05/Intramural NIH HHS/ -- New York, N.Y. -- Science. 2010 Jan 15;327(5963):335-8. doi: 10.1126/science.1181421. Epub 2009 Dec 10.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20007866" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Composition ; Cell Line ; Drosophila melanogaster ; *Gene Expression Regulation ; *Genes, Insect ; Genome, Insect ; Oligonucleotide Array Sequence Analysis ; *Promoter Regions, Genetic ; RNA/genetics/*metabolism ; RNA Caps/genetics/metabolism ; RNA Polymerase II/*metabolism ; RNA, Messenger/genetics/metabolism ; Transcription Initiation Site ; *Transcription, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Cell biology. A revolving door for calcium (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-10-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Demaurex, Nicolas -- Poburko, Damon -- New York, N.Y. -- Science. 2009 Oct 2;326(5949):57-8. doi: 10.1126/science.1180482.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell Physiology and Metabolism, University of Geneva, 1 Rue Michel-Servet, 1211 Geneva, Switzerland. nicolas.demaurex@unige.ch〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19797650" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Triphosphate/metabolism ; Animals ; Antiporters/deficiency/genetics/*metabolism ; Calcium/*metabolism ; *Calcium Signaling ; Calcium-Binding Proteins/deficiency/genetics/*metabolism ; Cation Transport Proteins/deficiency/genetics/metabolism ; Cell Line ; Cell Respiration ; Drosophila Proteins/genetics/*metabolism ; Drosophila melanogaster ; Genome ; Humans ; Hydrogen/*metabolism ; Hydrogen-Ion Concentration ; Ion Transport ; Membrane Proteins/deficiency/genetics/*metabolism ; Mitochondria/*metabolism ; Mitochondrial Membranes/metabolism ; Mitochondrial Proteins/*metabolism ; Potassium/metabolism ; RNA Interference ; Wolf-Hirschhorn Syndrome/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Increased chromosomal mutation rate after hybridization between two subspecies of grasshoppers (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-06-10
    Description: Hybridization between two chromosomally distinct subspecies of the grasshopper Caledia captiva results in a high incidence of novel chromosomal rearrangements among the backcross progeny. Rearrangements are restricted to those chromosomes derived from the F1 hybrid parent. Chromosomal involvement is nonrandom with the same rearrangement occurring repeatedly in different backcrosses. A single individual can also generate an array of different rearrangements among its offspring. Several of the rearrangements have also been found in natural populations. The nonrandom and recurrent nature of these chromosomal mutations at high frequencies provides a plausible explanation for the establishment and fixation of chromosomal rearrangements in natural populations.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shaw, D D -- Wilkinson, P -- Coates, D J -- New York, N.Y. -- Science. 1983 Jun 10;220(4602):1165-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6407107" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Evolution ; Chromosomes/*physiology ; Drosophila melanogaster ; Female ; Genetic Variation ; Grasshoppers/*genetics ; *Hybridization, Genetic ; Male ; *Mutation
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    A gene controlling condensation of heterochromatin in Drosophila melanogaster (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-07-01
    Description: A temperature-sensitive lethal mutant of Drosophila melanogaster was used to identify an essential cell cycle function that is necessary for the mitotic condensation of heterochromatic but not of euchromatic portions of the genome. This mutant is an allele at a locus (mus-101) identified earlier by the use of mutagen-sensitive mutants. The data suggest that the mutagen-sensitive and repair-defective phenotypes of viable mus-101 mutants result from a disruption in chromosome organization.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gatti, M -- Smith, D A -- Baker, B S -- GM23345/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 Jul 1;221(4605):83-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6407113" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Cycle ; Chromosomes/ultrastructure ; Drosophila melanogaster ; Female ; *Genes ; Heterochromatin/*genetics/physiology ; Male ; Mutation
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
    Electronic Resource
    Electronic Resource
    Increased oral clearance of metoprolol in pregnancy (1983)
    Springer
    European journal of clinical pharmacology 24 (1983), S. 217-220 
    Details
    ISSN: 1432-1041
    Keywords: metoprolol ; pregnancy ; hypertension ; kinetics ; pre-eclampsia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The disposition of oral metoprolol was studied in 5 women during the last trimester of pregnancy and 3 to 5 months after delivery. After a single oral dose of 100 mg the individual peak plasma concentration in the pregnant state was only 20–40% of that after pregnancy. The plasma half-lives of metoprolol were about the same during (average 1.3 h) and after pregnancy (average 1.7 h). By contrast, the area under the plasma concentration versus time curve was much smallerduring (mean 262 nmol/l×h) thanafter (mean 1298 nmol/l×h) pregnancy, resulting in an average apparent oral clearance (Clo) of metoprolol that was 4.4times higher during (362 ml×kg−1 body-weight×min−1) than after pregnancy. The increased Clo in pregnancy is assumed to be due to enhanced hepatic metabolism of the drug. The possible clinical consequence of the difference in the disposition of metoprolol is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00613820
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  • 8
    Electronic Resource
    Electronic Resource
    Felodipine — A new vasodilator, in addition to β-receptor blockade in hypertension (1983)
    Springer
    European journal of clinical pharmacology 25 (1983), S. 571-575 
    Details
    ISSN: 1432-1041
    Keywords: beta-blocker ; felodipine ; calcium antagonist ; hypertension ; vasodilator ; side effects ; plasma levels ; metoprolol ; propranolol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In a double-blind, cross-over trial, 10 men with primary hypertension, not adequately controlled with a β-blocker alone, were also given felodipine or placebo for periods of one week. Placebo was administered single-blind for 2 weeks and 1 week, respectively, before randomization and between treatments. The dose of felodipine ranged from 6.25 mg to 25 mg. The addition of felodipine resulted in a pronounced (20%), statistically significant reduction in blood pressure (BP) and a small but significant increase in heart rate (HR). The effects were seen within 1–2 h and were maximal after 3–4 h. During steady state treatment the duration of BP reduction was at least 12 h. No orthostatic reaction was seen. There was a significant correlation between the plasma concentration of felodipine and change in BP. The most frequently reported side-effects were headache and ankle oedema, the latter probably being due to pronounced pre-capillary vasodilatation. There was no weight increase and thus no indication of general water retention. No clinically significant change in laboratory variables and no influence on the P-Q time were seen. Thus, felodipine in combination with a β-blocker seems to be a useful addition to the treatment of hypertensive patients whose BP is not adequately controlled with a β-blocker alone.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542340
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  • 9
    Electronic Resource
    Electronic Resource
    Long acting beta-blockers in the twenty fourth hour (1983)
    Springer
    European journal of clinical pharmacology 25 (1983), S. 717-720 
    Details
    ISSN: 1432-1041
    Keywords: propranolol ; metoprolol ; exercise tests ; moderate hypertension ; oxygen uptake ; blood glucose
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Fifteen mild to moderate hypertensives were submitted to exercise testing using a bicycle ergometer with a fixed load. Heart rate, blood pressure and ECG were recorded throughout 5 min exercise and 10 min recovery. Oxygen uptake was measured during the final minute of exercise and blood glucose estimation and serum drug levels assessed 5 min after recovery. The above measurements were made after exactly 24 h following seven days administration of 160 mg of long acting (L.A.) propranolol, 200 mg of sustained action (S.A.) metoprolol and two matched placebos. Propranolol L.A. was superior to Metoprolol S.A. in the reduction of exercise induced tachycardia and both drugs were significantly superior to placebos. Both drugs were effective agents for the lowering of resting blood pressure after 24 h but propranolol L.A. was more effective in the lowering of systolic peaks observed during exercise. There was no significant effect upon oxygen uptake and blood glucose. The incidence of side effects was low and showed no significant difference from placebo.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542508
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  • 10
    Electronic Resource
    Electronic Resource
    Comparative pharmacokinetic profiles of metoprolol and chlorthalidone administered alone or in combination to healthy volunteers (1983)
    Springer
    European journal of clinical pharmacology 24 (1983), S. 655-660 
    Details
    ISSN: 1432-1041
    Keywords: metoprolol ; chlorthalidone ; co-administration ; pharmacokinetics ; healthy subjects ; drug interaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary A potential pharmacokinetic interaction between the beta-blocking drug, metoprolol, and the diuretic, chlorthalidone, has been investigated in three single or multiple dose studies in healthy volunteers. The pharmacokinetic profile of metoprolol 100 mg was not affected by pretreatment with or co-administration of chlorthalidone 25 mg twice daily. Similarly, the pre-dosing steady-state level of chlorthalidone during chronic treatment and its blood level profile after a single 25 mg dose were not affected by metoprolol. The bioavailabilities of the 2 drugs administered in combination were identical to those observed when each drug was administered alone. These studies demonstrate that there is no pharmacokinetic interaction between metoprolol and chlorthalidone when doses of 100 and 25 mg, respectively, are co-administered twice daily.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542217
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