Publication Date:
1998-02-07
Description:
Insulin-like growth factor-I (IGF-I) is a mitogen for prostate epithelial cells. To investigate associations between plasma IGF levels and prostate cancer risk, a nested case-control study within the Physicians' Health Study was conducted on prospectively collected plasma from 152 cases and 152 controls. A strong positive association was observed between IGF-I levels and prostate cancer risk. Men in the highest quartile of IGF-I levels had a relative risk of 4.3 (95 percent confidence interval 1.8 to 10.6) compared with men in the lowest quartile. This association was independent of baseline prostate-specific antigen levels. Identification of plasma IGF-I as a predictor of prostate cancer risk may have implications for risk reduction and treatment.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chan, J M -- Stampfer, M J -- Giovannucci, E -- Gann, P H -- Ma, J -- Wilkinson, P -- Hennekens, C H -- Pollak, M -- CA-42182/CA/NCI NIH HHS/ -- CA-58684/CA/NCI NIH HHS/ -- T32 CA 09001-20/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1998 Jan 23;279(5350):563-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA. jmlchan@hsph.harvard.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9438850" target="_blank"〉PubMed〈/a〉
Keywords:
Adult
;
Aged
;
Aged, 80 and over
;
Analysis of Variance
;
Case-Control Studies
;
Confidence Intervals
;
Disease Susceptibility
;
Humans
;
Insulin-Like Growth Factor Binding Protein 3/blood
;
Insulin-Like Growth Factor I/*analysis
;
Insulin-Like Growth Factor II/analysis
;
Male
;
Middle Aged
;
Odds Ratio
;
Prospective Studies
;
Prostate-Specific Antigen/blood
;
Prostatic Neoplasms/*etiology
;
Reference Values
;
Regression Analysis
;
Risk
;
Risk Factors
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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