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  • bioavailability  (28)
  • stress  (28)
  • Springer  (56)
  • American Chemical Society (ACS)
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  • 2015-2019
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  • 1980-1984  (56)
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  • 1983  (56)
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  • Springer  (56)
  • American Chemical Society (ACS)
  • American Geophysical Union
  • Institute of Physics
  • National Academy of Sciences
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  • 2015-2019
  • 2005-2009
  • 1990-1994
  • 1980-1984  (56)
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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of nutrition 22 (1983), S. 185-194 
    ISSN: 1436-6215
    Keywords: sugar substitutes ; D-glucose ; bioavailability ; D-glucitol (D-sorbitol) ; D-mannitol ; Palatinit® ; D-glucosyl-α(1→1)-D-mannitol ; D-glucosyl-α(1→6)-D-glucitol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Medicine
    Description / Table of Contents: Zusammenfassung Zur Vertiefung des Verständnisses vom Stoffwechsel des Zuckeraustauschstoffes Palatinit® wurden seine zwei Bestandteile D-Glucosyl-α(1→1)-D-mannit und D-Glucosyl-α(1→6)-D-glucit [D-Glucosyl-α(1→6)-D-sorbit] nach dem Verfahren von Karimzadegan et al. auf ihre Glucose-Bioverfügbarkeit an ketotischen Ratten untersucht. Bei Umwandlungsraten in Glucose von 6 bzw. 20 % für Mannit und Glucit (Sorbit) sowie von 39 bzw. 42% für Glucosylmannit und Glucosylglucit erhält demnach der metabolische Glucose-Pool nicht das volle Glucose-Äquivalent aus diesen Verbindungen. Von dem Anteil an präformierter Glucose in den Glucosylhexiten — theoretisches Maximum 50 % — sind nur 36 % aus Glucosylmannit bzw. 32 % aus Glucosylglucit bioverfügbar. Die im Vergleich zur Theorie verminderte Bioverfügbarkeit von Glucose aus Palatinit® wird auf partiellen mikrobiellen Abbau in unteren Darmabschnitten zurückgeführt. Die an Ratten erhaltenen Ergebnisse werden auch für alle anderen Spezies gelten, welche in Caecum und/oder Colon Kohlenhydrate vergären. Die Unterschiede zwischen D-Glucosyl-α(1→1)-D-mannit und D-Glucosyl-α(1→6)-D-glucit werden durch unterschiedliche Verzögerung der Glucoseresorption im Dünndarm, wo auch D-Glucit angreift, bedingt. Die Ermittlung der Glucose-Bioverfügbarkeit gewährt weitgehende Einblicke in das Schicksal von Kohlenhydraten einschließlich der Symbiose zwischen Säugetier und Mikroorganismen im Dickdarm. Da ein ziemlich vollständiger Überblick über die metabolischen Konsequenzen nach ihrer Zufuhr erhalten wird, sollte das Verfahren zur Messung der Bioverfügbarkeit von Glucose daher bei Abschätzungen der Lebensmittelsicherheit anderer Zuckeraustauschstoffe ebenfalls angewandt werden.
    Notes: Summary For the sake of metabolic insight into the fate of the sugar substitute Palatinit®, its two components D-glucosyl-α(1→1)-D-mannitol and D-glucosyl-α(1→6)-D-glucitol [D-glucosyl-α-(1→6)-D-sorbitol] were assayed for glucose bioavailability by the procedure of Karimzadegan et al. using ketotic rats. With conversion rates into glucose of 6 and 20 %, respectively, for free mannitol and glucitol (sorbitol), 39 % for glucosylmannitol and 42 % for glucosylglucitol, the metabolic glucose pool of the rat does not receive the full carbohydrate complement of these compounds. The preformed glucose moiety of the glucosylhexitols is bioavailable by 36 and 32 %, respectively, from glucosylmannitol and glucosylglucitol, with 50 % as theoretical maximum. Less than theoretical bioavailability of glucose from Palatinit® is ascribed to microbial attack in the hindgut. The data on rats are held valid also for other species demonstrating carbohydrate fermentation in the caecum and/or colon. Differences between D-glucosyl-α(1→1)-D-mannitol and D-glucosyl-α(1→6)-D-glucitol are caused by a differential delay of glucose absorption in the small intestine, also exerted by D-glucitol. The deep metabolic insight offered by the glucose bioavailability assay into the fate of carbohydrates includes the mammal-microbial symbiosis in the large bowel. Since a rather complete survey of the metabolic consequences after their intake can be obtained, the assay system should be generally applied in assessments of food safety also of other sugar substitutes.
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    International journal of earth sciences 72 (1983), S. 1167-1196 
    ISSN: 1437-3262
    Keywords: Experiment ; anisotropy ; stress ; strain ; pure shear ; simple shear ; buckling ; bending ; macroscopic fabric ; symmetry ; flexural-slip fold ; kink band ; Jura-Mountains ; Rhenish Massif (Rheinisches Schiefergebirge, Ruhr district)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Description / Table of Contents: Abstract An applicable interpretation of fabrics should be based mainly on geometrical considerations in order to cover available field data. Therefore a theory on the formation of foldtype fabrics including congruent and concentric flexural-slip folds as well as kink bands in materials subjected to rhombic and different monocline strain types is derived by means of particle motion fields for homogeneous and isotropic bodies. The analysis of experimental results and their comparison with field observations largely confirms the theory and contributes to its improvement. Some trends can be established: With increasing monocline character of the strain type, the probability of concentric and congruent flexural-slip folding is reduced. It is substituted by kink band formation. While the portion of monocline strain is enlarged with depth, rhombic fold symmetry indicates, in the realm of elastic-plastic behaviour, the proximity of the surface of the earth or of a detachment surface. With gradual increase of the rock anisotropy, the development of shear faults, kink folds and, finally, congruent and concentric flexural-slip folds is favoured.
    Abstract: Résumé L'interprétation, en vue de son application, de la genèse des formes structuraux résultant de processus tectoniques doit être basée essentiellement sur des raisonnements géométriques pour qu'elle corresponde à la structure des observations faites sur le terrain. Pour cette raison, une théorie de la formation des formes structuraux d'aspect plissé, y compris des plis semblables ou isopaques à glissement banc sur banc ainsi que des knicks, est développée à partir d'une figuration générale des mouvements des particules dans les corps homogènes et isotropes soumis à des déformations à symétrie orthorhombique ou monoclinique. L'analyse des résultats expérimentaux et des comparaisons avec des observations sur le terrain confirment largement la théorie et contribuent à son perfectionnement. Quelques tendances se dessinent: avec l'accroissement du caractère monoclinique de la déformation s'accroît aussi la probabilité de la formation des knicks plutôt que des plis à glissements banc sur banc, concentriques et congruents. Tandis que la déformation monoclinique prend une part plus importante avec la profondeur, la symétrie orthorhombique des plis en régime de déformation élastoplastique indique la proximité de la surface de la Terre ou d'une surface de décollement. Avec l'augmentation de l'anisotropie des roches, la formation de cassures de cisaillement, de knicks et enfin de plis semblables et isopaques à glissement banc sur banc est favorisée.
    Notes: Zusammenfassung Eine anwendungsbezogene Deutung der Gefügegenese muß in erster Linie auf geometrischen Überlegungen beruhen, damit sie auf Geländedaten übertragen werden kann. Ausgehend von Partikelbewegungsfeldern, die für homogene und isotrope Körper gelten, wird eine Theorie der Genese faltenförmiger Gefüge entwickelt, die konzentrische und kongruente Biegegleitfalten und Knickzonen bei rhombischen und monoklinen Deformationstypen erfaßt. Die Ergebnisse von Experimenten und der Vergleich mit Geländebefunden bestätigen weitgehend die Theorie und tragen zu ihrer Weiterentwicklung bei. Einige Trends zeichnen sich ab: Mit steigender Monoklinität des Deformationstyps nimmt die Wahrscheinlichkeit der Bildung von Knickzonen auf Kosten von konzentrischen und kongruenten Biegegleitfalten zu. Während der Anteil monokliner Deformation zur Tiefe hin größer wird, zeigt eine rhombische Symmetrie der Falten im elastisch-plastischen Bereich die Nähe der Erdoberfläche oder einer Abscherungsfläche an. Bei zunehmender Anisotropie werden zunächst bevorzugt Scherbrüche, dann Knickzonen und schließlich kongruente und konzentrische Biegegleitfalten gebildet.
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    International journal of earth sciences 72 (1983), S. 421-450 
    ISSN: 1437-3262
    Keywords: Experiment ; anisotropy ; stress ; strain ; pure shear ; simple shear ; buckling ; bending ; macroscopic fabric ; symmetry ; flexural-slip fold ; kink band ; Jura-Mountains ; Rhenish Massif (Rheinisches Schiefergebirge, Ruhr district)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Description / Table of Contents: Abstract An applicable interpretation of fabrics should be based mainly on geometrical considerations in order to cover available field data. Therefore a theory on the formation of foldtype fabrics including congruent and concentric flexural-slip folds as well as kink bands in materials subjected to rhombic and different monocline strain types is derived by means of particle motion fields for homogeneous and isotropic bodies. The analysis of experimental results and their comparison with field observations largely confirms the theory and contributes to its improvement. Some trends can be established: With increasing monocline character of the strain type, the probability of concentric and congruent flexural-slip folding is reduced. It is substituted by kink band formation. While the portion of monocline strain is enlarged with depth, rhombic fold symmetry indicates, in the realm of elastic-plastic behaviour, the proximity of the surface of the earth or of a detachment surface. With gradual increase of the rock anisotropy, the development of shear faults, kink folds and, finally, congruent and concentric flexural-slip folds is favoured.
    Abstract: Résumé L'interprétation, en vue de son application, de la genèse des formes structuraux résultant de processus tectoniques doit être basée essentiellement sur des raisonnements géométriques pour qu'elle corresponde à la structure des observations faites sur le terrain. Pour cette raison, une théorie de la formation des formes structuraux d'aspect plissé, y compris des plis semblables ou isopaques à glissement banc sur banc ainsi que des knicks, est développée à partir d'une figuration générale des mouvements des particules dans les corps homogènes et isotropes soumis à des déformations à symétrie orthorhombique ou monoclinique. L'analyse des résultats expérimentaux et des comparaisons avec des observations sur le terrain confirment largement la théorie et contribuent à son perfectionnement. Quelques tendances se dessinent: avec l'accroissement du caractère monoclinique de la déformation s'accroît aussi la probabilité de la formation des knicks plutôt que des plis à glissements banc sur banc, concentriques et congruents. Tandis que la déformation monoclinique prend une part plus importante avec la profondeur, la symétrie orthorhombique des plis en régime de déformation élastoplastique indique la proximité de la surface de la Terre ou d'une surface de décollement. Avec l'augmentation de l'anisotropie des roches, la formation de cassures de cisaillement, de knicks et enfin de plis semblables et isopaques à glissement banc sur banc est favorisée.
    Notes: Zusammenfassung Eine anwendungsbezogene Deutung der Gefügegenese muß in erster Linie auf geometrischen Überlegungen beruhen, damit sie auf Geländedaten übertragen werden kann. Ausgehend von Partikelbewegungsfeldern, die für homogene und isotrope Körper gelten, wird eine Theorie der Genese faltenförmiger Gefüge entwickelt, die konzentrische und kongruente Biegegleitfalten und Knickzonen bei rhombischen und monoklinen Deformationstypen erfaßt. Die Ergebnisse von Experimenten und der Vergleich mit Geländebefunden bestätigen weitgehend die Theorie und tragen zu ihrer Weiterentwicklung bei. Einige Trends zeichnen sich ab: Mit steigender Monoklinität des Deformationstyps nimmt die Wahrscheinlichkeit der Bildung von Knickzonen auf Kosten von konzentrischen und kongruenten Biegegleitfalten zu. Während der Anteil monokliner Deformation zur Tiefe hin größer wird, zeigt eine rhombische Symmetrie der Falten im elastisch-plastischen Bereich die Nähe der Erdoberfläche oder einer Abscherungsfläche an. Bei zunehmender Anisotropie werden zunächst bevorzugt Scherbrüche, dann Knickzonen und schließlich kongruente und konzentrische Biegegleitfalten gebildet.
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 24 (1983), S. 127-136 
    ISSN: 1432-1041
    Keywords: statistical analysis ; nonparametric statistical methods ; bioavailability ; confidence interval ; ANOVA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary For a two-way cross-over design, which appears to be the most common experimental design in bioavailability studies, 95%-confidence limits for expected bioavailability can be obtained by classical analysis of variance (ANOVA). If symmetry of the confidence interval is desired about zero (differences) or unity (ratios) rather than about the corresponding point estimator, Westlake's modification can be used. Two nonparametric methods and their adaptations to bioavailability ratios are reviewed, one based on Wilcoxon's signed rank test (Tukey), and the other on Pitman's permutation test. The necessary assumptions and the merits of these procedures are discussed. The methods are illustrated by an example of a comparative bioavailability study. A FORTRAN program facilitating the procedures is available from the authors upon request.
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 24 (1983), S. 791-796 
    ISSN: 1432-1041
    Keywords: furosemide ; bioavailability ; diuretic effect ; urine sodium ; urine potassium ; power of ANOVA ; tablet formulations ; urinary flow rate ; normal volunteers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The relative bioavailability and diuretic effect of 2 commercially available tablet preparations of furosemide 40 mg was examined in 10 healthy male volunteers. A close linear relationship between the urinary excretion rate of furosemide and the rate of sodium ion excretion in urine and/or flow rate of urine was demonstrated. There were no significant differences in the urinary excretion of furosemide, sodium and potassium ions or urinary volume following the oral doses. The difference in drug content affected the urinary recovery of furosemide over 24 h but had no effect on the pharmacological response. The analytical power of ANOVA using the various parameters of the responses to furosemide was no lower than when the parameters of urinary excretion of furosemide were used.
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 25 (1983), S. 237-241 
    ISSN: 1432-1041
    Keywords: triamterene ; bioavailability ; pharmacokinetics ; metabolism ; hydroxy triamterene sulphate ; urinary excretion ; i.v. administration ; first-pass-effect
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary With a new formulation, which made intravenous infusion of triamterene (TA) possible, plasma levels and urinary excretion rates of TA and its main metabolite (OH-TA-ester) were measured in a randomized, cross-over trial in 6 healthy volunteers given triamterene 10 mg i.v. and 50 mg p.o. TA and OH-TA-ester were determined by densitometric measurement of native fluorescence after thin layer chromatography. Distribution volumes of the central compartment of TA and OH-TA-ester were 1.49 l/kg and 0.11 l/kg, respectively. Terminal half-lives were 255 min for TA and 188 min for OH-TA-ester after i.v. administration. For TA total plasma clearance was 4.5 l/min and renal plasma clearance 0.22 l/kg. The formation of OH-TA-ester was very rapid and the concentration of the metabolite exceeded that of TA at all times. After i.v. administration the urinary recovery of TA and OH-TA-ester was 4.4% and 50.9%, respectively. The bioavailability of TA was 52%, corresponding to absorption of 83%. TA is partly eliminated by a first-pass-effect. The main metabolite of TA is OH-TA-ester, which is pharmacologically active.
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 25 (1983), S. 449-453 
    ISSN: 1432-1041
    Keywords: canrenone ; pharmacokinetics ; plasma level ; bioavailability ; urinary excretion ; spironolactone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Five healthy male volunteers received canrenoate-K 200 mg (Sincomen® pro injectione) by intravenous injection and one week later spironolactone 200 mg (Sincomen®-100) orally. Plasma levels and urinary excretion of unchanged canrenone were determined up to 24 h by a specific HPLC method. Following intravenous administration, the maximum plasma level of 2066±876 ng/ml was found after 29±15 min and thereafter the concentration declined with a half-life of 3.7±1.2 h. Total clearance was 4.2±1.7 ml/min·kg. After oral ingestion, the maximum concentration of 177±33 ng/ml was observed at 4.4±0.9 h. The absolute bioavailability of canrenone was 25±9%. Within 24 h, respectively 0.4 and 0.6 mg, canrenone were excreted by the kidney after intravenous and oral administration. The half-life of elimination was 4.9±1.8 h (i.v.) and 3.9±1.2 h (p.o.).
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 24 (1983), S. 103-108 
    ISSN: 1432-1041
    Keywords: dexamethasone ; bioavailability ; pharmacokinetics ; ‘first-pass’ effect ; pre-systemic elimination
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics and oral biovailability of dexamethasone were studied in 6 patients with neurological disease being treated with high dosages of the drug. A specific high performance liquid chromatographic assay was used to measure dexamethasone concentrations. Unlike the previously published mean figure of 0.78 for the oral bioavailability of the drug given in single doses to healthy volunteers, the mean bioavailability of dexamethasone in the patients studied was 0.53±SD 0.40. It appeared more likely that this incomplete bioavailability was due to presystemic elimination than to poor absorption. The intravenous clearance of the drug was relatively high (0.4902±SD 2291 l kg−1, approximately 65% of expected hepatic plasma flow), the oral clearance higher (2.5804±SD 3.2181 l kg−1 h−1) while the absorption rate constant (4.8729±8.4998 h−1), suggested rapid absorption after oral administration. Prior phenytoin and possibly prior dexamethasone therapy is likely to have contributed to the higher clearance values of the drug in these patients than the values reported in healthy volunteers after single dose studies.
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  • 9
    ISSN: 1432-1041
    Keywords: oxmetidine ; pharmacokinetics ; bioavailability ; plasma half-life ; clearance ; oral dose ; i.v. dose
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The plasma concentration curves and urinary excretion of oxmetidine after administration of single i.v. (100 mg) and oral (200 mg) doses have been studied in 11 patients with peptic ulcer disease. The mean bioavailability of the drug was 70% (range 53–91%). After intravenous administration, the mean plasmat 1/2β was 3.0 h, the mean apparent volume of distribution 0.7 l/kg, the mean total plasma clearance 12.3 l/h and the mean plasma renal clearance was 0.7 l/h. Following intravenous and oral administration an average of 6% and 3%, respectively, of unchanged drug was found in the urine. The plasma concentration curve after oral administration in most patients exhibited two maxima, with peak concentrations appearing between 45 and 210 min after dosing.
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 25 (1983), S. 689-693 
    ISSN: 1432-1041
    Keywords: amiodarone ; bioavailability ; calculation ; linear pharmacokinetics ; absorption
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Methods for estimating the bioavailability of drugs with long elimination half-lives are examined. Provided both absorption and disposition are linear a simple linear regression method is developed which can be used to calculate bioavailability in situations where only an incomplete estimate of the area under the curve (AUC) is available. The regression method and the traditional method of comparing the AUC following an oral dose to the AUC following an i.v. dose were applied to simulated data. It was found that the AUC ratio method works well as long as absorption is complete within the time over which the AUC is computed. The regression method is less precise than the AUC ratio method but is more accurate for drugs with long absorption half-lives. When applied to published data on a beta blocker the two methods produced comparable results. The bioavailability of amiodarone in three human subjects was calculated to be 0.20, 0.44 and 0.98 using the regression method with similar results from the ratio method. It is not possible to estimate the clearance of amiodarone from single dose data.
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