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  • Organic Chemistry  (695)
  • Animals  (443)
  • 1995-1999
  • 1980-1984  (1,138)
  • 1975-1979
  • 1982  (1,138)
Collection
Keywords
Publisher
Years
  • 1995-1999
  • 1980-1984  (1,138)
  • 1975-1979
Year
  • 11
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    Quantitative autoradiographic mapping of herpes simplex virus encephalitis with a radiolabeled antiviral drug (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-09-17
    Description: 2'-Fluoro-5-methyl-l-beta-D-arabinosyluracil (FMAU) labeled with carbon-14 was used to image herpes simplex virus type 1-infected regions of rat brain by quantitative autoradiography. FMAU is a potent antiviral pyrimidine nucleoside which is selectively phosphorylated by virus-coded thymidine kinase. When the labeled FMAU was administered 6 hours before the rats were killed, the selective uptake and concentration of the drug and its metabolites by infected cells (defined by immunoperoxidase staining of viral antigens) allowed quantitative definition and mapping of HSV-1-infected structures in autoradiograms of brain sections. These results show that quantitative autoradiography can be used to characterize the local metabolism of antiviral drugs by infected cells in vivo. They also suggest that the selective uptake of drugs that exploit viral thymidine kinase for their antiviral effect can, by appropriate labeling, be used in conjunction with clinical neuroimaging techniques to define infected regions of human brain, thereby providing a new approach to the diagnosis of herpes encephalitis in man.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Saito, Y -- Price, R W -- Rottenberg, D A -- Fox, J J -- Su, T L -- Watanabe, K A -- Philips, F S -- New York, N.Y. -- Science. 1982 Sep 17;217(4565):1151-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7112121" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Antiviral Agents ; Arabinofuranosyluracil/*analogs & derivatives ; Autoradiography ; Cytarabine/analogs & derivatives ; Encephalitis/microbiology/*pathology ; Herpes Simplex/*pathology ; Rats ; Uridine/*analogs & derivatives
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 12
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    Are ions involved in the gating of calcium channels? (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-10-08
    Description: The rates of activation and deactivation of the currents carried by calcium, strontium, or barium ions through the voltage-sensitive calcium channel of Paramecium are different. The differences cannot be attributed to complications due to internal ion concentration, calcium channel inactivation, potassium current activation, surface charge effects, or incomplete space clamping. The findings indicate participation of the divalent cations in the voltage-driven calcium channel gating process.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Saimi, Y -- Kung, C -- GM22714/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1982 Oct 8;218(4568):153-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6289432" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Barium/metabolism ; Calcium/*metabolism ; Cell Membrane/physiopathology ; Ion Channels/*metabolism ; Kinetics ; Membrane Potentials ; Paramecium/*physiology ; Strontium/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 13
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    Impulse-coded and analog signaling in single mechanoreceptor neurons (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-03-26
    Description: Although most sensory neurons convey temporally coded impulses to the central nervous system, certain nonspiking receptors use only graded afferent signals. Each of three large nerve fibers from the lobster oval organ, a mechanoreceptor subserving ventilation, carry both impulses and graded potentials. Thus, both impulse frequency and receptor potential amplitude are available for information transfer.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pasztor, Y M -- Bush, B M -- New York, N.Y. -- Science. 1982 Mar 26;215(4540):1635-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7071583" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials/drug effects ; Afferent Pathways/physiology ; Animals ; Mechanoreceptors/*physiology ; Membrane Potentials ; Nephropidae ; Tetrodotoxin/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 14
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    Polyamines inhibit the protein kinase 380--catalyzed phosphorylation of eukaryotic initiation factor 2 alpha (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-01-22
    Description: Polyamines putrescine, spermidine, and spermine specifically inhibit the PK 380--catalyzed phosphorylation of eukaryotic initiation factor 2 alpha (eIF-2 alpha). Since te PK 380--dependent phosphorylation of eIF-2 alpha inhibits the initiation or protein synthesis, the possibility exists that the polyamines enhance protein synthesis by inhibiting the phosphorylation of eIF-2 alpha by PK 380.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kuroda, Y -- Merrick, W C -- Sharma, R K -- CA-16091/CA/NCI NIH HHS/ -- GM-26796/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1982 Jan 22;215(4531):415-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7058326" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenal Cortex/enzymology/*physiology ; Animals ; Cattle ; Cell-Free System ; Peptide Chain Initiation, Translational/drug effects ; Peptide Initiation Factors/*metabolism ; Phosphoproteins/metabolism ; Phosphorylation ; Polyamines/*pharmacology ; *Protein Kinase Inhibitors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 15
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    Reversal of induced ischemic neurologic deficit in gerbils by the opiate antagonist naloxone (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-01-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hosobuchi, Y -- Baskin, D S -- Woo, S K -- New York, N.Y. -- Science. 1982 Jan 1;215(4528):69-71.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6274019" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain Ischemia/*complications ; Cerebrovascular Disorders/chemically induced/*drug therapy ; Gerbillinae ; Hemiplegia/*drug therapy/etiology ; Levorphanol ; Male ; Morphine ; Naloxone/*therapeutic use ; Receptors, Opioid/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 16
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    Postural asymmetry and movement disorder after unilateral microinjection of adrenocorticotropin 1-24 in rat brainstem (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-10-08
    Description: A unilateral microinjection of adrenocorticotropin 1-24 in the rat brainstem in the region of the locus ceruleus resulted in postural asymmetry and movement disorder that resembled human dystonia, the severity and duration (2 to 3 days) being dose-dependent. These results show for the first time that neuropeptides in the brainstem may modulate posture and movement, and they suggest that some forms of movement disorder such as dystonia may be due to a disordered regulation of postural and locomotor mechanisms by adrenocorticotropin 1-24.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jacquet, Y F -- Abrams, G M -- K07 00478/PHS HHS/ -- New York, N.Y. -- Science. 1982 Oct 8;218(4568):175-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6289433" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenocorticotropic Hormone/*analogs & derivatives ; Animals ; Brain Stem/drug effects/*physiology ; Cosyntropin/*pharmacology ; Male ; Microinjections ; Motor Activity/*drug effects ; *Posture ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 17
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    Multiplication of tobacco mosaic virus in tobacco leaf disks is inhibited by (2'-5) oligoadenylate (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-06-25
    Description: The oligonucleotide (2'-5') oligoadenylate that is induced in interferon-treated animal cells protects plant tissue from infection by the tobacco mosaic virus. This inhibition of virus multiplication was obtained at concentrations comparable to those affecting protein synthesis and antiviral activities in animal cells. After treatment with (2'-5') oligoadenylate, the multiplicability of tobacco mosaic virus was reduced by 80 to 90 percent as measured by enzyme-linked immunosorbent assay. These results, along with the observation that human interferon protects tobacco tissue from infection by tobacco mosaic virus, indicate that plants and animals may have a common pathway for virus resistance.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Devash, Y -- Biggs, S -- Sela, I -- New York, N.Y. -- Science. 1982 Jun 25;216(4553):1415-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6178155" target="_blank"〉PubMed〈/a〉
    Keywords: Adenine Nucleotides/*pharmacology ; Animals ; Cells, Cultured ; Interferons/pharmacology ; Kinetics ; Oligonucleotides/*pharmacology ; Oligoribonucleotides/*pharmacology ; Plants, Toxic ; Tobacco/microbiology ; Tobacco Mosaic Virus/*drug effects ; Virus Replication/drug effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 18
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    Quantitative electron microscopic autoradiography of insulin, glucagon, and somatostatin binding sites on islets (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-09-17
    Description: After monolayer cultures of rat islets were exposed to [(125)I]insulin,[(125)I]glucagon, and [(125)I]tyrosinyl somatostatin, specific autoradiographic grains associated with each radioactively labeled ligand were found on B, A, and D cells. The density of labeling of the B, A, and D cells with each labeled ligand correlated well with the known actions of the three hormones on each of the islet cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Patel, Y C -- Amherdt, M -- Orci, L -- AM 21373/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1982 Sep 17;217(4565):1155-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6126003" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cells, Cultured ; Islets of Langerhans/cytology/*metabolism/ultrastructure ; Microscopy, Electron ; Rats ; Receptor, Insulin/*metabolism ; Receptors, Cell Surface/*metabolism ; Receptors, Glucagon ; Receptors, Somatostatin ; Somatostatin/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 19
    Electronic Resource
    Electronic Resource
    Sila-Riechstoffe, 2. Sila-Linalool (1982)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 1982 (1982), S. 734-738 
    Details
    ISSN: 0170-2041
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Sila-Perfumes, 21)  -  Sila-LinaloolMethyl(4-methyl-3-pentenyl)vinylsilanol (2), the sila derivative of the naturally occuring linalool (1), could be prepared from dichloro(methyl)vinylsilane following the outlined method. The intensity of odour of 2 is similar to that of 1 but its note is somewhat shifted from the fragrance of lilies of the valley to that of hyacinths. Furthermore, a forerunner of 2 (chlorosilane 4), a reaction product of 2 (disiloxane 6), and some compounds from parallel investigations, e. g. the chlorosilane 3 or the morpholino silane 5, are described.
    Notes: Methyl(4-methyl-3-pentenyl)vinylsilanol (2), das Siladerivat des natürlich vorkommenden Linalools (1), konnte ausgehend von Dichlor(methyl)vinylsilan auf dem skizzierten Reaktionsweg dargestellt werden. Seine Geruchsintensität ist der von 1 gleich, seine Geruchsnote vom Maiglöckchenduft des Linalools etwas zum Hyazinthenduft hin verschoben. Es werden eine Vorstufe von 2 (Chlorsilan 4), ein Reaktionsprodukt von 2 (Disiloxan 6) sowie in Paralleluntersuchungen auftretende Verbindungen wie das Chlorsilan 3 oder das Morpholinosilan 5 beschrieben.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.198219820414
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  • 20
    Electronic Resource
    Electronic Resource
    Amidingruppenhaltige geminale DiphosphonsäurenHerrn Prof. Dr. L. Horner zum 70. Geburtstag gewidmet. (1982)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 1982 (1982), S. 275-281 
    Details
    ISSN: 0170-2041
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Geminal Diphosphonic Acids Containing Amidino GroupsThe reaction of amides or nitriles with H3PO3/PCl3 leads in some cases to the formation of amidinoalkylidenediphosphonic acids. In the case of formamide under specific conditions, amidino-methylenediphosphonic acid (4) is formed, with succin- or glutaramides (or with the nitriles) the heterocyclic, geminal diphosphonic acids 10 are obtained. By the reaction of 2-pyrrolidinone 12 with PCl3/H2O in addition to the expected 2,2-pyrrolidinylidenediphosphonic acid (11a) an amidine is isolated, for which the structure 15 is suggested. The alkaline hydrolyses of these compounds and the corresponding reaction products are described.
    Notes: Die Reaktion von Säureamiden oder Nitrilen mit PCl3/H3PO3 führt in einigen Fällen zur Bildung von Amidinoalkylidendiphosphonsäuren. So bilden sich aus Formamid unter geeigneten Bedingungen Amidinomethylendiphosphonsäure (4) und aus Bernstein- oder Glutarsäurediamiden(-dinitrilen) die heterocyclischen, geminalen Diphosphonsäuren 10. Bei Umsetzung von 2-Pyrrolidinon (12) mit PCl3/H2O kann neben der erwarteten 2,2-Pyrrolidinylidendiphosphonsäure (11a) ein Amidin isoliert werden, für das die Konstitution 15 vorgeschlagen wird. Die alkalischen Hydrolysen der Verbindungen werden beschrieben und ihre Reaktionsprodukte isoliert.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.198219820211
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