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  • Artikel  (42)
  • Autoradiography  (21)
  • NDE  (21)
  • Springer  (42)
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  • Oxford University Press
  • 1980-1984  (42)
  • 1981  (42)
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  • Artikel  (42)
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  • 1980-1984  (42)
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  • 1
    Digitale Medien
    Digitale Medien
    Springer
    Development genes and evolution 190 (1981), S. 233-236 
    ISSN: 1432-041X
    Schlagwort(e): Sulphate ; Glycosaminoglycan ; Autoradiography ; Gastrulation ; Chick
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Summary Chick blastoderms were cultured for 2 h in the presence of35S-sulphate. The distribution of the grains after light microscope autoradiography was compared in blastoderms during the elongation and during the shortening of the primitive streak. A uniform labeling was observed over the cells in both groups. Accumulation of grains was present in both groups at the ventral side of the upper layer, where transmission electron microscope studies have revealed a basal lamina. An additional accumulation of grains occurred over the cells and in the extracellular spaces of the head process and of the rostral part of blastoderms with shortening primitive streaks. This positivity could be correlated with the presence of ingressing and recently ingressed notochordal cells. Treatment of the sections with chondroitinase ABC and/or HNO2 before dipping in the nuclear emulsion demonstrated that at least chondroitin sulphate and N-sulphated heparan sulphate were present.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Springer
    Planta 152 (1981), S. 137-144 
    ISSN: 1432-2048
    Schlagwort(e): Autoradiography ; Intranuclear crystals ; Nucleus, crystolo-Protein transfer-Pteridophytes ; Scolopendrium
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract Proteinaceous intranuclear crystals are found in the fern Scolopendrium vulgare. During mitosis these crystals are eliminated from the nucleus into the cytoplasm, where they are dissolved. New crystals appear in the nucleus. The site of synthesis of intranuclear crystal proteins was investigated using quantitative ultrastructural autoradiography after incubation with tritiated lysine. The results suggest a migration of cytoplasmic proteins to the nucleus, part of which would then be incorporated into the intranuclear crystals.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Springer
    Journal of nondestructive evaluation 2 (1981), S. 57-63 
    ISSN: 1573-4862
    Schlagwort(e): ultrasonics ; correlation ; pseudorandom codes ; random signals ; NDE
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik , Mathematik
    Notizen: Abstract A new portable digital random signal flaw detection system is described which uses a digital delay line to replace the acoustic delay line of the original random signal system. Using this new system, a comparison was made between the two types of transmit signals which have been used in previous systems—m-sequences and random signals. This comparison has not been possible with these previous correlation flaw detection systems. Results indicated that for high-speed short code operation, the m-sequences produced slightly lower range sidelobes than typical samples of a clipped random signal. For normal long code operation, results indicated that system performance is essentially equivalent in resolution and signal-to-noise ratio using either m-sequences or clipped and sampled random signals. Further results also showed that for normal long code operation, the system produces outputs equivalent in resolution to pulse-echo systems, but with the added benefit of signal-to-noise ratio enhancement.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 4
    Digitale Medien
    Digitale Medien
    Springer
    Journal of nondestructive evaluation 2 (1981), S. 85-111 
    ISSN: 1573-4862
    Schlagwort(e): Holographic reconstruction ; ultrasound ; NDE ; Rayleigh-Sommerfeld formula
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik , Mathematik
    Notizen: Abstract For the purpose of ultrasonic nondestructive testing of materials, holography in connection with digital reconstruction algorithms has been proposed as a modern tool to extract crack sizes from ultrasonic scattering data. Defining the typical holographic reconstruction algorithm as the application of the scalar Kirchhoff diffraction theory to backward wave propagation, we demonstrate its general incapability of reconstructing equivalent sources, and hence, geometries of scattering bodies. Only the special case of a planar measurement recording surface, that is to say, a hologram plane, and a planar crack with perfectly rigid boundary conditions parallel to the hologram plane and perpendicular to the incident field yields a nearly perfect correlation between crack size and reconstructed image; the reconstruction algorithm is then referred to as the Rayleigh-Sommerfeld formula; it therefore represents the optimal case matched to that special geometrical situation and, hence, may be interpreted as a quasi-matched spatial filter. Using integral equation theory and physical optics, we compute synthetic holographic data for a linear cracklike scatterer for both plane and spherical wave incidence, the latter case simulating a synthetic aperture impulse echo situation, thus illustrating how the Rayleigh-Sommerfeld algorithm or its Fresnel approximation increasingly fail for cracks inclined to the hologram plane and excited nonperpendicularly. Furthermore, we point out how the physical data recording process may additionally influence the reconstruction accuracy, and, finally, guidelines for a careful and serious application of these holographic reconstruction algorithms are given. The theoretical results are supported by measurements.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 5
    Digitale Medien
    Digitale Medien
    Springer
    Journal of nondestructive evaluation 2 (1981), S. 203-207 
    ISSN: 1573-4862
    Schlagwort(e): ultrasonics ; synthetic aperture ; spatial frequency ; interior imaging ; acoustic microscopy ; defect detection ; NDE
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik , Mathematik
    Notizen: Abstract A new acoustic synthetic aperture geometry is demonstrated in which the image field is sampled in the spatial frequency domain. This means the sampled field is recorded in a particularly convenient form for presentation to the back propagation algorithms used to reconstruct the field at the object plane. The method has applications in interior visualization. It is difficult to image the interior of solid objects using lens based imaging systems because a different lens geometry must be used for each distinct object material. The system presented here overcomes such problems since both the angular variation of the transmission coefficient at the object-water interface and the aberrations introduced by the velocity mismatch at the object surface may be readily compensated for in the back propagation routine. Experimental results are presented illustrating the detection of four half wavelength diameter defects, spaced by three wavelengths, at a depth of eight wavelengths below the surface of an aluminum block.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 6
    Digitale Medien
    Digitale Medien
    Springer
    Journal of nondestructive evaluation 2 (1981), S. 241-247 
    ISSN: 1573-4862
    Schlagwort(e): ultrasonic field ; numerical methods ; transducer design ; NDE
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik , Mathematik
    Notizen: Abstract A simple, flexible, accurate, and comprehensive numerical method is presented for theoretically analyzing the diffraction field of a continuous wave transducer of arbitrary size, shape, and frequency. Using the extensively studied circular transducer for comparison, numerical results are shown for an unfocused transducer with uniform velocity excitation as well as for a focused transducer with Gaussian velocity excitation. Data concerning the execution time, program size, and convergence of the method are also presented for its implementation as a design tool on a minicomputer system.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 7
    Digitale Medien
    Digitale Medien
    Springer
    Journal of nondestructive evaluation 2 (1981), S. 23-33 
    ISSN: 1573-4862
    Schlagwort(e): austenitic stainless steel ; austenitic stainless steel welds ; eddy current inspection ; eddy current testing ; electromagnetic testing ; ferromagnetic steel inspection ; flaw characterization ; flaw detection ; NDE ; multifrequency eddy current inspection ; weld inspection
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik , Mathematik
    Notizen: Abstract This paper describes the initial phase of a project to develop eddy-current methods to inspect welds joining sections of austenitic stainless steel pipe having walls up to 13 mm (0.5 in.) thick. The objective of this phase was to demonstrate the feasibility of detecting and characterizing flaws in austenitic stainless steel base metals. These materials and welds present challenging eddy-current problems because of their relatively large thickness and ferromagnetism. Multiparameter analysis shows that a reflection coil probe operated with three discrete driver frequencies and phase detection can locate and size a cracklike defect in a single conductor in the presence of variations in conductor resistivity, permeability, and thickness and in the probe-conductor spacing (liftoff). Experiments were performed with a modular three-frequency instrument. Flat-plate specimens of types 304L and 347 stainless steel machined to 12.7 to 15.9 mm thickness simulated pipe walls; saw-cut slots 10 to 30% of nominal specimen thickness simulated cracklike defects. The same slots were used in duplicate experiments as near-side (directly under the test probe) or far-side (in the face opposite the probe) defects. Flaw detection and characterization capability was demonstrated by a series of experimental measurements fitted to specimen properties by least squares techniques. The quality of the fit determined the expected accuracy of measurement. Comparison of accuracy estimates determined the best choice of operating frequencies. From the 1,2,5 sequence of frequencies between 0.5 and 20 kHz, the optimum set of operating frequencies was selected to be 0.5, 2, and 10 kHz. Estimates of measurement accuracy for combined near- and far-side defect cases were: plate thickness, 0.74 mm; probe liftoff, 0.03 mm; defect location (depth of material above defect), 3.48 mm; and defect size (vertical slot depth), 1.09 mm. A few property values were back-calculated from instrument readings; the errors in these values were somewhat larger than the measurement accuracy estimates because of instrument drift and the absence of calibration circuits.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 8
    Digitale Medien
    Digitale Medien
    Springer
    Journal of nondestructive evaluation 2 (1981), S. 35-41 
    ISSN: 1573-4862
    Schlagwort(e): acoustic emission ; crack growth ; 7075 aluminum ; NDE
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik , Mathematik
    Notizen: Abstract For slow crack growth (da/dn ≈0.1 µm per load cycle) in 7075-T6 aluminum, quantitative agreement was found between the amplitude distribution of burst acoustic emissions and the area size distribution of intermetallic inclusions ≈10 (µm)2 in area as measured on thepolished fracture face. This observation permits the prediction of the amplitude distribution of acoustic emissions due to crack growth in a particular sample of 7075-T6 aluminum directly from a simple, standard metallographic observation performed on the material in question. It was also found that a reduction of the yield stress from that of 7075-T6 aluminum (503 MPa) to that of 7075-0 aluminum (103 MPa) completely eliminated burst acoustic emission activity due to crack advance in the amplitude range studied.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 9
    Digitale Medien
    Digitale Medien
    Springer
    Journal of nondestructive evaluation 2 (1981), S. 119-124 
    ISSN: 1573-4862
    Schlagwort(e): Stress intensity factor ; annular crack ; finite element methods ; fatigue ; NDE
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik , Mathematik
    Notizen: Abstract Results of finite element static stress intensity factor calculations for an annular crack around a spherical inclusion (void) are presented and compared with those from approximate analytical methods.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 10
    Digitale Medien
    Digitale Medien
    Springer
    Journal of nondestructive evaluation 2 (1981), S. 147-149 
    ISSN: 1573-4862
    Schlagwort(e): Ultrasonic tomography ; residual stress ; NDE
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik , Mathematik
    Notizen: Abstract Ultrasonic tomography is being explored as a potential tool to map residual stresses in solids. The angular scanning required in tomography imposed limitations on the stress configuration adaptable to such a treatment. These are discussed in the following note.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 11
    Digitale Medien
    Digitale Medien
    Springer
    Journal of nondestructive evaluation 2 (1981), S. 161-172 
    ISSN: 1573-4862
    Schlagwort(e): elastodynamic inverse scattering ; ultrasonics ; data reduction ; ill-posed problems ; NDE
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik , Mathematik
    Notizen: Abstract The practical significance of ill-posedness in a data reduction problem is reviewed. Inverse elastodynamic scattering is shown to be ill-posed in general, although suitably restricted problems may be well-posed. These results underscore the need to analyze carefully the errors of data reduction problems in NDE, and to focus attention on final results of an NDE exercise, rather than on intermediate steps.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 12
    Digitale Medien
    Digitale Medien
    Springer
    Journal of nondestructive evaluation 2 (1981), S. 153-159 
    ISSN: 1573-4862
    Schlagwort(e): ultrasonics ; scattering ; cracks ; periodic surface perturbation ; NDE
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik , Mathematik
    Notizen: Abstract The scattering of a plane longitudinal wave from a two-dimensional crack, with a sinusoidal surface perturbation whose amplitude and wavelength are much smaller than the length of the crack, is investigated. The amplitude of the cylindrical body waves in the far field are calculated from a Kirchhoff approximation that utilizes the solution to the reflection from the sinusoidal surface profile of a semiinfinite solid. The results are compared to those for a flat crack, and conditions for significant differences of the amplitude as a function of the angle of observation are discussed. Characteristic changes in the scattered field produced by profiles with different amplitudes and periods are explained.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 13
    Digitale Medien
    Digitale Medien
    Springer
    Journal of nondestructive evaluation 2 (1981), S. 195-202 
    ISSN: 1573-4862
    Schlagwort(e): ac potential difference ; fatigue crack measurement ; slots ; artificial flaws ; parasitic voltages ; NDE
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik , Mathematik
    Notizen: Abstract The development of a successful and accurate instrument for measuring surface-breaking cracks in metals using the ac field technique has raised several interesting theoretical problems. Measurements with the instrument, known as the Crack Microgauge, do not rely on any prior calibration against an artificial flaw such as a saw-cut in a test block, but some users accustomed to such a calibration from other devices have nevertheless wished to use the instrument in that fashion and have in some instances reported erroneous results. In this paper, we develop a simple theory to explain and quantify this phenomenon. We calculate the parasitic voltages induced in the instrument probe due to the finite opening possessed by an artificial flaw, and we use these results to reinterpret the instrument readings. Controlled experimental measurements on artificial flaws of rectangular cross-section made in aluminum and in steel are found to be in good agreement with the theory. It is shown, however, that application of the theory requires additional information about the internal phase shift associated with the instrument. To enhance the accuracy of the theory, the effect of the corners of the artificial flaws was also considered, although it was not very influential in this work.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 14
    Digitale Medien
    Digitale Medien
    Springer
    Journal of nondestructive evaluation 2 (1981), S. 43-49 
    ISSN: 1573-4862
    Schlagwort(e): Rayleigh wave dispersion ; higher mode generation ; cold-working ; rail ; NDE
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik , Mathematik
    Notizen: Abstract The propagation of the Rayleigh surface wave is experimentally studied along the top surface of used railroad rail under conditions where ultrasonic pulses have carrier frequencies ranging from 0.4 to 3.0 MHz and approximately 10 µs duration. The generation of the first higher (M 21 or Sezawa) mode as well as the fundamental (M 11) mode and their dispersion properties are observed. These phenomena are attributable to the presence of the cold-worked surface layer caused by the wheel passage. It is shown that a theoretical model of a single layer overlying a half space, whose elastic constants are determined by a destructive method, yields results which agree with the dispersion curves obtained experimentally. On the basis of this one-layered model, an inversion method to estimate the layer thickness and its elastic constants is discussed.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 15
    Digitale Medien
    Digitale Medien
    Springer
    Journal of nondestructive evaluation 2 (1981), S. 65-74 
    ISSN: 1573-4862
    Schlagwort(e): NDE ; cast iron ; vibration analysis ; modulus ; strength
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik , Mathematik
    Notizen: Abstract An outline is given of the existing nondestructive vibration tests for cast irons and their drawbacks in terms of the dimensional accuracy of the components. A proposal is made for a new test based on the change of resonant frequency with vibration amplitude exhibited by cast irons. This proposal is evaluated using material data obtained from dynamic tests of a wide range of cast iron specimens. A test rig is described suitable for testing cylindrical cast bars, and typical results are presented in relation to material strength. There is also a brief description of preliminary testing on cast products.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 16
    Digitale Medien
    Digitale Medien
    Springer
    Journal of nondestructive evaluation 2 (1981), S. 113-118 
    ISSN: 1573-4862
    Schlagwort(e): Capacitance ; dielectric constant ; voids ; cellular glasses ; NDE
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik , Mathematik
    Notizen: Abstract Cellular (foamed) glasses are a prime candidate for certain structural applications, such as support of the silvered glass concentrator mirrors in solar thermal energy systems. An economical nondestructive measurement of strength-limiting defects in these materials would permit development of designs in which the material is subjected to a higher working stress level and maintains the same probability of failure. This would result in weight and cost savings for any application. A method of measuring the capacitance of well-defined regions of a specimen was investigated. Large voids were found to produce significant localized changes in the capacitance of the specimen. The feasibility of locating the large, strength limiting defects in this porous material has been demonstrated for one type of cellular glass. Means of producing an image from this type of data and an implementation scheme for on-line production measurements are discussed.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 17
    Digitale Medien
    Digitale Medien
    Springer
    Journal of nondestructive evaluation 2 (1981), S. 139-146 
    ISSN: 1573-4862
    Schlagwort(e): Material defects ; 14 MeV neutrons ; pulse-shape analyzer system ; NDE
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik , Mathematik
    Notizen: Abstract A 14 MeV neutron generator and fast neutron spectrometer consisting of an organic scintillation detector and a pulse-shape analyzer are used for the nondestructive testing of materials. The 14.6 MeV peak (in the 12.7–15.7 MeV region) is observed to change as a function of both the kind of testing material and the defect condition inside the material. The number of neutron counts under the 14.6 MeV peak for lighter testing materials (e.g., plastic, brass, and aluminum) with a defect will increase, as compared to the number of neutron counts under the same peak region of an identical testing material but with no defect. For heavier testing materials (e.g., steel and lead), the inverse is observed. The method is feasible even with defects of size 0.25 cm3 (i.e., a cylindrical cavity 0.4 cm in diameter and 2.0 cm in length), although quantitative evaluation of the size of the defect as a function of the change of the number of neutron counts under the 14.6 MeV peak region is difficult due to instability of the 14 MeV neutron output.
    Materialart: Digitale Medien
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  • 18
    Digitale Medien
    Digitale Medien
    Springer
    Journal of nondestructive evaluation 2 (1981), S. 219-229 
    ISSN: 1573-4862
    Schlagwort(e): acoustics ; surface acoustic waves ; Rayleigh waves ; ceramics ; surface cracks ; residual stresses ; crack extension ; NDE
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik , Mathematik
    Notizen: Abstract An investigation of scattering from surface cracks has been conducted. In particular, the change in the reflection coefficient of a Rayleigh wave incident on a surface indentation crack has been measured as the sample is stressed to fracture. The acoustic measurements have been correlated with the stable crack extension that precedes final failure. The crack extension behavior of as-indented specimens was found to differ appreciably from that of annealed specimens. Cracks in the annealed samples exhibited partial crack tip closure, but little stable extension, whereas cracks in the as-indented samples displayed both crack closure and irreversible crack growth. This behavior has been rationalized by invoking concepts based upon the residual stresses created by indentation.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 19
    Digitale Medien
    Digitale Medien
    Springer
    Journal of nondestructive evaluation 2 (1981), S. 51-55 
    ISSN: 1573-4862
    Schlagwort(e): Love wave dispersion ; surface layer ; work hardening ; rail ; NDE
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik , Mathematik
    Notizen: Abstract In this paper, experiments show Love wave generation along the top surface of used railroad rail, where the shear wave velocity has been slightly reduced by the cold-working of wheel passage for years. The rf pulses used in the experiments have about 10 µs duration and a relatively narrow frequency spectrum. The group velocity of the Love wave is found to have a strong dependence on the carrier frequency over the tested range of 0.45–3.1 MHz. Application of the seismological one-layered model to the experimental measurements yields an NDE technique for the elastic properties and the thickness of the cold-worked surface layer. The results are interpreted on the basis of a destructive observation by micro-Vickers hardness testing.
    Materialart: Digitale Medien
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  • 20
    Digitale Medien
    Digitale Medien
    Springer
    Journal of nondestructive evaluation 2 (1981), S. 75-84 
    ISSN: 1573-4862
    Schlagwort(e): digital signal processing ; microprocessor based system ; binary display ; ordered dither ; ultrasonic C-scan ; image magnification ; NDE
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik , Mathematik
    Notizen: Abstract The use of a digital microprocessor based system for the acquisition of ultrasonic C-scan information is investigated. The C-scan information is displayed on a binary display device using electronic ordered dither techniques to represent gray levels. The digital system with a binary display increases system flexibility and yields better reproducibility and constant image quality independent of the display medium. Images may be stored on magnetic tape or disk for later retrieval and image processing. The techniques which are described allow for image magnification and a reduction in scan time by replacing the mechanical linkage between the scanner and the display with digital signals. A detailed comparison is made between two dither signals, and the advantages of each are discussed. The combination of digital signal processing and imaging techniques produces results which utilize the capabilities of ultrasonic inspection to the point where the transducer becomes the limiting factor.
    Materialart: Digitale Medien
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  • 21
    Digitale Medien
    Digitale Medien
    Springer
    Journal of nondestructive evaluation 2 (1981), S. 133-138 
    ISSN: 1573-4862
    Schlagwort(e): X-rays ; diffraction ; grain size determination ; NDE
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik , Mathematik
    Notizen: Abstract It is shown that the grain size of commercial materials can be estimated by x-rays with little or no sample preparation. The method is readily automated and can be employed on-line, for example, in a rolling mill.
    Materialart: Digitale Medien
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  • 22
    Digitale Medien
    Digitale Medien
    Springer
    Journal of nondestructive evaluation 2 (1981), S. 173-188 
    ISSN: 1573-4862
    Schlagwort(e): ultrasonics ; acoustic imaging ; computer image analysis ; failure prediction ; inhomogeneous materials ; accept/reject criteria ; NDE
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik , Mathematik
    Notizen: Abstract A computerized technique is presented which has been developed for analyzing acoustic images of an inhomogeneous material. The acoustic imaging system is briefly described with emphasis on its adaptation to billets of graphite for atmospheric reentry body use. Ultrasonic images of such inhomogeneous material contain a nonuniform distribution of anomalies and few, if any, geometrically regular features which can be assessed to establish material integrity. Results obtained with our new algorithms show, for certain discriminants, a high degree of correlation between the numerical accept/reject values obtained from acoustic image processing and the time-to-failure of the graphitic material in simulated atmospheric reentry tests.
    Materialart: Digitale Medien
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  • 23
    Digitale Medien
    Digitale Medien
    Springer
    Journal of nondestructive evaluation 2 (1981), S. 209-217 
    ISSN: 1573-4862
    Schlagwort(e): honeycomb panels ; acoustic inspection ; leaky waves ; SH and Lamb waves ; line scan ; NDE
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik , Mathematik
    Notizen: Abstract This paper considers the properties of elastic waves guided by an aluminum plate bonded to a honeycomb core for application to rapid inspection of honeycomb panels. Current acoustic inspection techniques involve the transmission of a signal between a pair of small transducers located on opposite sides of the panel. Scanning the transducers in raster fashion results in a high resolution inspection of the panel, but is very time consuming. An alternative technique would simultaneously inspect all points along a line between two widely spaced transducers located on the same side of the panel. Scanning the pair once over the panel permits rapid inspection, although with decreased resolution. Studies presented here indicate that such a method of inspection is feasible and that the flexural mode is probably the most useful.
    Materialart: Digitale Medien
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  • 24
    Digitale Medien
    Digitale Medien
    Springer
    Cell & tissue research 216 (1981), S. 215-220 
    ISSN: 1432-0878
    Schlagwort(e): Autoradiography ; 3H-proline ; Osteoblasts ; Sympathectomy ; Guanethidine-sulfate
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary Sympathectomy was carried out in rats by injections of guanethidine-sulfate from birth to 14 days of age. At 45 days of age, the activity of osteoblastic cells was monitored by 3H-proline autoradiography. Effectiveness of sympathectomy was verified by light-microscopic examination of superior cervical and celiac ganglia. Grain counts over periosteal osteoblasts of the femoral diaphysis and osteoblasts mesial to the first molar in the mandible demonstrated a significantly reduced uptake of 3H-proline in the sympathectomized rats. The data provide direct evidence of sympathetic influence on osteoblastic activity and suggest that sympathectomy may result in the loss of a trophic influence which is important in the regulation of osteogenesis.
    Materialart: Digitale Medien
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  • 25
    Digitale Medien
    Digitale Medien
    Springer
    Cell & tissue research 215 (1981), S. 643-649 
    ISSN: 1432-0878
    Schlagwort(e): T-lymphocytes ; Blast cells ; Autoradiography ; Electron microscopy ; Stereology
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary As a companion to an earlier study, the morphometric attributes of stimulated (blast-derived) lymphocytes in mouse axillary lymph nodes have been established using stereological and autoradiographic methods. Blast transformation was induced in vivo with dinitrochlorobenzene (DNCB) and stimulated cells were labelled with tritiated thymidine. Random samples of cells were taken for light and electron microscopic morphometry. In comparison to the unstimulated lymphocyte, the stimulated cell increased in size and possessed a greater plasma membrane surface area. Increase in cell size was the result of increases in the volumes of all measured subcellular compartments both in the nucleus and the cytoplasm. Heterogeneity of the stimulated cell population precludes firm conclusions regarding the significance of all these ultrastructural changes, though alterations in cell surface are discussed in the context of known biochemical differences accompanying blastogenesis.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 26
    Digitale Medien
    Digitale Medien
    Springer
    Protoplasma 107 (1981), S. 221-233 
    ISSN: 1615-6102
    Schlagwort(e): Autoradiography ; Cell wall synthesis ; Chitin ; Hypomyces
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Summary The incorporation of the chitin precursor N-acetyl-D-(1-3H) glucosamine byH. chlorinus has been studied by light and electron microscopic autoradiography. Light microscopic autoradiography showed that the incorporation occured preferentially at the hyphal apex. Autoradiograms from electron microscopy were quantitatively evaluated to determine the relative radioactivity incorporation between the cell wall and cytoplasm: this showed that (3H) incorporation took place mainly in the plasmalemma-wall complex. However a small amount of N-acetyl glucosamine can enter into the cytoplasmic space and is then transported by endomembranes (Golgi apparatus-vesicles) to the plasmalemma-cell wall interface before polymerization.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 27
    Digitale Medien
    Digitale Medien
    Springer
    Parasitology research 64 (1981), S. 335-345 
    ISSN: 1432-1955
    Schlagwort(e): Hymenolepis diminuta ; Autoradiography ; Ultracytochemistry ; Histochemistry
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Abstract Histochemical studies on the rostellum ofHymenolepis diminuta revealed diastase-stable, protein/neutral carbohydrate-rich material localized in the rostellum tegument. The remainder of the rostellum, primarily composed of the glycogen-rich myocytons of the rostellum musculature, is protein-poor, but rich in diastase-labile, neutral and acidic carbohydrates. Ultrastructural cytochemical studies, using the periodic acid-thiocarbohydrazideosmium (PATCO) technique, indicated that the granules of the rostellar tegumental cytons and distal cytoplasm are carbohydrate-rich. Lipids are present in the rostellar myocytons but not in the tegumental cytons. Autoradiography using a pulse-labeling with [3H]leucine revealed an apical translocation of tegumental granules, but at a slower rate than had been reported for the strobilar tegument of the same organism. Neither [3H]galactose nor [3H]glucose were incorporated into the rostellar tegumental granules. The function of the secretory glycoprotein(s) produced in the rostellar tegument and its (their) possible role in the regulation of maturation and/or strobilization remain enigmatic.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 28
    Digitale Medien
    Digitale Medien
    Springer
    Cell & tissue research 220 (1981), S. 153-161 
    ISSN: 1432-0878
    Schlagwort(e): Cytoplasmic transport ; Insect ovary ; Autoradiography ; Electron microscopy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary The ovarioles of Coccinella and Tenebrio are shown to be telotrophic — a characteristic normally associated with hemipterans rather than coleopterans. They possess an anterior region of trophic cells and a chain of oocytes. The trophic cells are connected with the latter by a series of nutritive tubes, and autoradiography has shown that RNA is transported along the tubes to the oocytes. However, the system in these beetles differs markedly from that of hemipterans in that the nutritive tubes do not contain an extensive complement of aligned microtubules. The significance of this to both the mechanism and the selectivity of transport is discussed.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 29
    Digitale Medien
    Digitale Medien
    Springer
    Cell & tissue research 214 (1981), S. 659-662 
    ISSN: 1432-0878
    Schlagwort(e): Vestibular system ; Postural control ; Deoxyglucose method ; Autoradiography ; Flatfish
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary [14C]2-deoxyglucose uptake by neurons located in the octavo-lateralis complex of adult flatfish is asymmetrical on the two sides of the brain. It appears that the neuronal activity on the side oriented upward is higher than that on the side of the brain facing downward. This finding may be significant with respect to the mechanisms of metamorphosis of flatfish and may account for the peculiar fact that these animals swim on one body side during adult live.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 30
    ISSN: 1432-0878
    Schlagwort(e): Colchicine ; Human enterocyte ; Glycoprotein transport ; Autoradiography ; Biochemistry
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary The effect of colchicine on the intracellular transport of 3H-fucose-labelled glycoproteins in the absorptive cells of cultured biopsy specimens of the human intestine was investigated by light- and electron-microscopical autoradiography and by biochemical methods. The results showed a decrease in the radioactivity of the cell coat on the microvilli and an increase in the Golgi apparatus and in the apical vesicles and tubules. This divergence is attributed to a colchicine-induced impairment of the normal transport of cell-coat glycoproteins from the Golgi apparatus, via the apical vesicles and tubules, to the apex of the cell. The radioactivity of the lysosome-like bodies in the absorptive cells cultured with colchicine also increased. This finding supports a crinophagic function of these organelles in the degradation of excess cell-coat material. The investigations were supported in part by the Foundation for Medical Research (FUNGO), which is subsidized by the Netherlands Organisation for the Advancement of Pure Research
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 31
    Digitale Medien
    Digitale Medien
    Springer
    Cell & tissue research 215 (1981), S. 75-86 
    ISSN: 1432-0878
    Schlagwort(e): Pituitary cells ; Estrogen ; Progesterone ; Autoradiography ; Immunocytochemistry
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary The effects of progesterone pretreatment on in vivo 3H-estrogen uptake by five anterior pituitary cell types was analyzed by means of a quantitative autoradiographic-immunocytochemical technique. Male and female rats castrated for 14 days show nuclear concentration of label in all five cell types one h after injection of 3H-estradiol, whether progesterone treated or not. The order of labeling intensity is gonadotropes ≧ lactotropes = somatotropes 〉 thyrotropes = corticotropes. Progesterone treatment induces a dramatic sexual dimorphism in estrogen uptake; it significantly increases 3H-estrogen uptake in all female cell types. In males, progesterone decreases uptake in gonadotropes while not altering uptake in other cell types.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 32
    Digitale Medien
    Digitale Medien
    Springer
    Cell & tissue research 219 (1981), S. 403-415 
    ISSN: 1432-0878
    Schlagwort(e): Monoamine precursors ; Ganglia ; Molluscs ; Autoradiography
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary In vitro-uptake and localization of 3H-5-hydroxytryptophan and 3H-dihydroxyphenylalanine have been investigated by means of light microscopic autoradiography in the central nervous system of the freshwater mussel, Anodonta cygnea L. Accumulation of the labelled monoamine precursors could be observed both over neuronal perikarya and neuropil in the ganglia. 3H-5-hydroxytryptophan and 3H-dihydroxyphenylalanine were taken up by neurons characterized by a small size (10–20 μm), a polygonal form and an intense staining with toluidine blue. Labelled axon branches situated either in the neuropil or between nerve cells in the cortex exhibited only a moderate activity, frequently of a diffuse character. After pretreatment for 24 h with colchicine, silver grains were also seen over the neuronal perikarya and some axon profiles. This shows that local uptake of the monoamine precursors and, presumably, the synthesis of the monoamines takes place both at perikaryal and axonal/terminal level. The nerve cells accumulating the monoamine precursors contain a nucleus with rich chromatin content and a deeply invaginated nuclear envelope. Further ultrastructural characteristics of these neurons are their well-developed rough endoplasmic reticulum system, a great number of mitochondria and glycogen granules, and the presence of dense-cored vesicles of different types. All these features are responsible for the electron-dense appearance of the cytoplasm.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 33
    Digitale Medien
    Digitale Medien
    Springer
    Cell & tissue research 214 (1981), S. 633-640 
    ISSN: 1432-0878
    Schlagwort(e): Rat ovary ; 125I-HCG binding ; Autoradiography ; Hormone receptors
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary Neither homogenates nor frozen ovarian sections of rats aged 1, 5 and 7 days demonstrated specific binding of 125I-HCG. However, from day 10 to day 35, the homogenates could bind specifically, with an equilibrium association constant in the range of 0.9–2.7 × 1010 M−1. The binding capacity increased from 5.8 fmol/mg tissue at day 10 to 15.7 fmol/mg tissue at day 35. As revealed by autoradiography, the frozen ovarian sections from 10-day-old rats showed 125I-HCG binding localized over the interstitial and thecal tissues and, in the older age groups, also in the granulosa cells of follicles larger than 500 μm in diameter. These results indicate that LH/HCG receptors appear in the rat ovary at the beginning of the second postnatal week, and that the interstitial cells are the main site of action of LH before puberty.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 34
    Digitale Medien
    Digitale Medien
    Springer
    Cell & tissue research 215 (1981), S. 499-504 
    ISSN: 1432-0878
    Schlagwort(e): Androgen receptors ; Pituitary gland ; Rhesus monkey ; Autoradiography ; Immunocytochemistry
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary The uptake and retention of radiolabelled dihydrotestosterone by the pituitary gland was examined in the rhesus monkey. Two animals were given an intravenous injection of 1.0μg/kg 3H-dihydrotestosterone (DHT) alone while one monkey received both the labelled androgen and 100μg/kg of unlabelled steroid. One and a half hours later, they were sacrificed. The pituitary glands were removed and processed for autoradiography and immunocytochemistry. Autoradiographic localization of DHT was discernible in the partes nervosa, intermedia and distalis, albeit the highest concentration of radiolabelled cells was noted in the pars distalis. Immunocytochemical staining with antibodies to rat PRL, human TSHβ and ovine LHβ revealed a population of steroid-concentrating cells that contained TSH and a second group that contained LH. None of the cells that reacted with the anti-PRL serum were radiolabelled.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 35
    Digitale Medien
    Digitale Medien
    Springer
    Cell & tissue research 217 (1981), S. 569-576 
    ISSN: 1432-0878
    Schlagwort(e): Autoradiography ; 3H-proline ; Osteoblasts ; Denervation
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary The inferior alveolar nerve was unilaterally resected in 30-day-old mice; other animals were unilaterally sham-operated. At 15, 30, 60, 90, or 150 days after surgery, the mice were injected with 2μCi of 3H-proline (sp. act. 1.0 Ci/mM) per g of body weight and killed 15, 30, or 60 min later. Autoradiographs were prepared from 5μm decalcified sagittal sections of mandibles and grain counts made over periosteal osteoblasts mesial to the first molar. In denervated mandibles, osteoblasts incorporated less isotope compared to controls with differences being maximal at the early intervals. These differences became attenuated with time, possibly due to an intrinsic compensatory mechanism, secondary to neurotrophic regulation.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 36
    Digitale Medien
    Digitale Medien
    Springer
    Cell & tissue research 218 (1981), S. 59-73 
    ISSN: 1432-0878
    Schlagwort(e): Germinal centers ; B-cell differentiation ; Lymphocyte migration ; Autoradiography ; Lymphoid tissue ; Appendix (rabbit)
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary The migration pattern of germinal center cells of the rabbit appendix was studied and compared with that of appendix dome cells, spleen cells, thymus cells and thoracic duct lymphocytes. To discriminate T-and B-cell migration pathways, normal or T-cell-depleted rabbits were used as donors. Cell suspensions were labeled in vitro with 3H-leucine followed by intravenous transfer. The migration of labeled cells in lymphoid organs was studied using autoradiography, particular attention being paid to the spleen of the recipient. B-cells from the appendix dome, spleen and thoracic-duct lymph migrate to primary follicles or the corona of secondary follicles via thymus-dependent areas of peripheral lymphoid organs. In contrast, a B-cell subpopulation from the germinal centers of the appendix migrates to the center of splenic primary follicles and into germinal centers. The migration of germinal center cells to splenic follicle centers is not enhanced by specific antigens. The migration properties of B-cells, possibly changing during differentiation, may be instrumental in the two types of immune reactions, i.e., plasma-cell reaction and germinal-center reaction.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 37
    Digitale Medien
    Digitale Medien
    Springer
    Cell & tissue research 220 (1981), S. 773-780 
    ISSN: 1432-0878
    Schlagwort(e): Estrogen receptors ; Uterus ; Armadillo ; Autoradiography
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary The uptake and retention of radiolabeled estradiol by the uterus was examined in the armadillo. One pregnant and two non-pregnant armadillos were treated with 1.4 μg/kg body weight of 3H-estradiol (E2) by injection into the left ventricle, and one non-pregnant animal was injected with both the labeled hormone and 140 μg/kg body weight of unlabeled E2. One and a half hour after injection, the animals were sacrificed and the uteri were removed and processed for autoradiography. In the non-pregnant animals, nuclear localization was observed in the interstitial cells and glandular epithelium of the endometrium and the connective tissue cells and smooth muscle of the myometrium. Additionally, there was a gradation of uptake in the epithelial cells of the endometrium in that the glandular cells of the basal region were heavily labeled, while those cells in the sinusoidal, and luminal regions contained successively less label. The luminal cells were poorly labeled. In the pregnant female, the smooth muscle and glandular cells hypertrophied and their nuclei contained less label than was observed in the non-pregnant animals. The arteries of the myometrium were more easily distinguished in the pregnant animals and the nuclei of the endothelial cells and smooth muscle were more consistently labeled than those of the non-pregnant armadillos.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 38
    Digitale Medien
    Digitale Medien
    Springer
    Cell & tissue research 220 (1981), S. 873-879 
    ISSN: 1432-0878
    Schlagwort(e): γ-Aminobutyric acid (GABA) ; Autoradiography ; Thyroid gland ; Transport ; Rat
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary The uptake of γ-aminobutyric acid (GABA) in the thyroid gland of the rat was studied autoradiographically following in vitro incubation. High-affinity GABA uptake was localized in follicle cells, whereas C cells (parafollicular cells) in general did not accumulate GABA by high-affinity transport. The follicle cells were also the main sites of low-affinity GABA uptake. Additionally, some nerve fibres were found to accumulate GABA. The predominant localization of GABA uptake in follicle cells is discussed in view of a presumed role of GABA in thyroid function.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 39
    ISSN: 1432-0878
    Schlagwort(e): 1,25(OH)2 ; Vitamin D3 ; Receptors ; Parathyroid glands ; Autoradiography
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary After injection of radiolabeled 1,25 (OH)2 vitamin D3, nuclear concentration of radioactivity is observed in parenchymal cells of the parathyroid gland in pregnant, adult male, and 10-day male neonatal rats. In competition studies with unlabeled 1,25 (OH)2 vitamin D3, but not with 25 (OH) vitamin D3, nuclear uptake is prevented. Experiments with 3H 25 (OH) vitamin D3, in contrast to 3H 1,25 (OH)2 vitamin D3, do not show nuclear concentration in cells of the parathyroid. The results of the autoradiographic studies suggest the presence of receptors for a direct effect of 1,25 (OH)2 vitamin D3 on the parathyroid gland for modulation of parathyroid hormone secretion.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 40
    Digitale Medien
    Digitale Medien
    Springer
    Cell & tissue research 219 (1981), S. 185-195 
    ISSN: 1432-0878
    Schlagwort(e): Glucose ; Pyloric gland ; Ascidian ; Autoradiography
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary The movement of labelled glucose along the digestive tract of two ascidian species, Sidnyum argus and Dendrodoa grossularia is compared. In Dendrodoa grossularia, glucose absorption takes place in all parts of the digestive tract except the oesophagus. Labelled glucose passes through the digestive tract in less than 12 h, and it accumulates in the pyloric ampullae in less than 3 days. In this species, the pyloric gland has more capacity to stock glucidic compounds than other tissues. Under normal feeding conditions, after five days, there is no transfer of labelled glucose to other tissues. Whatever the substances given to Sidnyum argus, its pyloric gland never accumulates labelled products.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 41
    Digitale Medien
    Digitale Medien
    Springer
    Cell & tissue research 219 (1981), S. 173-183 
    ISSN: 1432-0878
    Schlagwort(e): Ovary (dog) ; Atresia ; Thymidine ; Autoradiography
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary Autoradiography after pulse labelling with [3H] thymidine was applied to investigate the proliferation processes in the granulosa and theca related to follicular atresia of the dog ovary during metestrus. The number of proliferating cells depends on the follicle type and its atretic stage. There is less proliferation in smaller secondary follicles than either in larger ones or tertiary follicles. While in early atresia tertiary follicles show the highest labelling indices, in advanced atresia the larger secondary follicles are those with the highest values. For each follicle type a decline in the labelling indices can be observed from early to terminal atresia. Tertiary follicles show a precipitous decrease in the labelling index between early and advanced atresia. There is a continuous gradient of proliferation from the center of the follicle over the peripheral granulosa to the theca. In tertiary follicles, an inverse correlation between labelling and necrosis of granulosa cells can be observed.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 42
    Digitale Medien
    Digitale Medien
    Springer
    Cell & tissue research 219 (1981), S. 159-172 
    ISSN: 1432-0878
    Schlagwort(e): Seminal vesicles ; Proliferation ; Autoradiography ; Biochemistry ; Rat
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary Intraperitoneal injection of p-chlorophenylalanine (pCPA) methylester (100 mg/kg body weight) results in an activation of the lysosomal system of the secretory cells in the rat seminal vesicle and an elevation of the activities of lysosomal enzymes within 15 min following the injection. Large autophagic vacuoles are formed, sequestering rough endoplasmic reticulum and part of the Golgi apparatus within 2 h. Shortly after the activation of the lysosomal system an elevation of both DNA and protein synthesis is measured biochemically. 6 h subsequent to the injection a wave of mitoses of the secretory cells begins, reaching a maximum 6 h later and then declining within 3 h. About 12 h following the injection a second rise in lysosomal activity begins, declining within 24 h. The entire sequence of lysosomal and proliferative activities is inhibited in antiandrogen-pretreated rats. Deduced from these findings the following hypothesis of growth regulation of the accessory sex glands is advanced: enhanced loss of intracellular material during autophagocytosis diminishes the intracellular concentration of a substance curtailing cell division below its effective threshold resulting in division of the secretory cells. The prerequisites of this mechanism are (i) a sufficient distributive capacity of the stroma for hormones (androgens) and metabolic precursors, and (ii) sufficient capacity of the basal cells for transporting the precursors to the secretory cells. Sloughing of the secretory cells separates them from these auxiliary structures (stroma and basal cells) and enables the basal cells to divide.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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